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europepmc
2025
置信度 0.80
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europepmc
2025
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2025
置信度 0.80
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2025
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2025
置信度 0.80
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europepmc
2025
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europepmc
2026
置信度 0.80
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europepmc
2025
置信度 0.80
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europepmc
2025
置信度 0.80
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europepmc
2025
置信度 0.80
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europepmc
2025
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2025
置信度 0.80
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europepmc
2025
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2025
置信度 0.80
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europepmc
2025
置信度 0.80
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The 2021 World Health Organization (WHO) Classification of Tumors of the Central Nervous System (fifth edition, WHO CNS5) marks a profound paradigm shift from traditional morphologic assessment to a biologically and molecularly integrated diagnostic framework.…
pubmed
Lian M, Wu E, Kuai G, Zhu G 等
2026
置信度 0.82
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To analyse discordances between p53 immunohistochemistry (IHC) and TP53 next-generation sequencing (NGS) in endometrial cancer, with a focus on underlying mechanisms and their clinical implications. Despite increasing recognition of IHC-NGS discordance, a stru…
pubmed
Szatkowski W, Harazin-Lechowska A, Kluz T, Dudek A 等
2026
置信度 0.82
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Carcinogenesis involves two major phases: somatic evolution of normal tissue toward tumor formation, followed by tumor progression toward malignancy. Standard differential expression analysis cannot assign genes specifically to either phase. We introduce N- an…
pubmed
Gil G, Perez R, Gonzalez A
2026
置信度 0.82
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Periodontitis is a chronic inflammatory disease that leads to the destruction of tooth-supporting tissues and remains a major cause of tooth loss worldwide. Its pathogenesis involves complex interactions between microbial pathogens and host immune responses, w…
pubmed
Rizal MI, Bachtiar EW, Bachtiar BM, Soeroso Y 等
2026 Jul
置信度 0.82
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Long-term memory (LTM) formation requires activated gene expression in response to neuronal activity. Chromatin remodeling is thought to play a role in this transcriptional response, but the mechanisms remain unclear. In Drosophila melanogaster, a transcriptio…
pubmed
Jones SG, Raun N, Blackwood C, Miandashti N 等
2026 Aug 6
置信度 0.82
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Food adulteration is a widespread global issue threatening consumer health and food safety. The Grocery Manufacturers Association estimates that 10-15% of food products worldwide are adulterated, posing significant health risks and substantial economic losses.…
pubmed
Kumar A, Sousa C, Kakkar S, Prado M 等
2026 Aug 6
置信度 0.82
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Targeted protein degradation (TPD) has redefined the therapeutic landscape by shifting the focus from merely inhibiting protein function to actively eliminating disease-causing proteins. However, the clinical translation of TPD agents remains hampered by their…
pubmed
Zhu H, Zhang Y, Ning Y, Yang C 等
2026 Aug 5
置信度 0.82
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Male infertility is a global reproductive health issue, and sperm from the majority of infertile males exhibit motility defects. Although anatomical and endocrinological etiologies underlying male infertility have been identified and become targets for clinica…
pubmed
Lee JY, Hwang JY
2026 Jul 24
置信度 0.82
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Grapevine phenolic compounds play key roles in plant defense and wine quality. Composition depends on factors such as maturity and infections such as grey mold caused by Botrytis cinerea. Grapevines respond to infections by actively modifying their phenolic pr…
pubmed
Umberath KM, Backmann L, Scharfenberger-Schmeer M, Wegmann-Herr P 等
2026 Aug 5
置信度 0.82
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Bone marrow failure syndromes (BMFs) comprise a heterogeneous group of genetic disorders characterized by impaired hematopoiesis and multisystem involvement. Dyskeratosis congenita (DC) is a telomere biology disorder caused by defects in telomerase or telomere…
pubmed
Somekh I, Mandola AB, Frizinsky S, Lev A 等
2026 Aug
置信度 0.82
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Bacterial communities play important roles in the plant phyllosphere. Both microbial communities and their hosts exhibit endogenous circadian rhythms while simultaneously responding to environmental changes across the diurnal cycle. However, the interaction be…
pubmed
Dos Santos RAC, Hidalgo-Martinez K, Muñoz-Perez JM, Laspisa DJ 等
2026 Aug 6
置信度 0.82
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Brassinosteroids (BRs) are chemically diverse plant steroid hormones produced via a branched biosynthetic pathway. The potent BR brassinolide is sensed by the membrane receptor kinase BRI1 and a SERK co-receptor, but the physiological functions of other abunda…
pubmed
Caregnato A, Chen H, Kvasnica M, Hohmann U 等
2026 Aug 5
置信度 0.82
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A tunable interface between flying photons and stationary quantum states is important for quantum networks. Quantum-confined charged excitons are attractive in this context because they combine single-photon emission with localized charge states. However, real…
pubmed
Sun Z, Shehabeldin M, Tang J, Guo M 等
2026 Aug 5
置信度 0.82
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There is ongoing debate regarding the degree to which transcription factors (TFs) independently specify genomic binding: TF binding motifs are typically short and degenerate, yielding many more binding site predictions than observed in cells. Here we present g…
pubmed
Jolma A, Hernandez-Corchado A, Yang AWH, Fathi A 等
2026 Aug 5
置信度 0.82
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In recent decades, there has been active research into how ionizing radiation at low doses, an inevitable factor in human activity, affects aging processes and which molecular genetic mechanisms underlie this influence. This study investigates the effects of m…
pubmed
Yushkova E
2026 Aug 5
置信度 0.82
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pubmed
Moorman A, Benitez EK, Cambuli F, Jiang Q 等
2026 Aug 5
置信度 0.82
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Targeted protein degradation is a powerful pharmacological strategy that harnesses the ubiquitin proteasome system to eliminate disease-relevant proteins, including otherwise undruggable proteins 1 . Here we report an unbiased and broadly applicable platform f…
pubmed
Yoon H, Wachter F, Barrett KA, Jin C 等
2026 Aug 5
置信度 0.82
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The functional impact of a large portion of the human genome known as "dark matter DNA", which is composed mainly of repeat sequences, remains unknown. The genome also encodes many putative and poorly characterized transcription factors. Here, we determine gen…
pubmed
Razavi R, Fathi A, Yellan I, Brechalov A 等
2026 Aug 5
置信度 0.82
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The factors maintaining antimicrobial resistance genes (ARGs) in non-domesticated animal microbiomes remain unclear for species inhabiting human-dominated or less human-impacted landscapes. We analysed 875 gut metagenomes from natural populations of house mice…
pubmed
Gicquel M, Planillo A, Heitlinger E, Forslund-Startceva SK 等
2026 Aug 5
置信度 0.82
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Transcription factors (TFs) are key players in eukaryotic gene regulation, but the DNA binding specificity of many TFs remains unknown. Here, we assay 284 mostly uncharacterized putative human TFs using selective microfluidics-based ligand enrichment followed …
pubmed
Gralak AJ, Faltejskova K, Yang AWH, Steiner C 等
2026 Aug 5
置信度 0.82
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Randomized clinical trials are becoming very challenging to perform in oncology both in rare cancers and in more common cancers, fragmented according to molecular characteristics.
pubmed
Jooste V, Bouvier AM, Lepage C, Taieb J 等
2026 Aug 5
置信度 0.82
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Plant nitrogen uptake and utilization are governed by a complex network involving nitrate transporters and signal-responsive genes. Here, we show that the high mobility group box 1 protein OsHMGB1 directly binds to the OsNRT2.2 promoter and functions as a tran…
pubmed
Niu J, Guo Y, Cheng J, Ying S 等
2026 Aug 5
置信度 0.82
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Chitin is one of the most abundant biopolymers and has attracted growing interest due to its biodegradability, renewability, and expanding applications. However, conventional chitin extraction methods rely heavily on harsh chemicals and energy-intensive proces…
pubmed
Kan I, Erdocia X, Morales A, Kaya M 等
2026 Aug 5
置信度 0.82
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Cholesterol transport plays a pivotal role in regulating development and metabolism in Caenorhabditis elegans, a sterol-auxotrophic organism. Here, we identify the nematode cholesterol-binding protein STARD3 and provide structural and functional evidence for i…
pubmed
Battista B, Sambrailo A, Biglione FA, Lombardo VA 等
2026 Aug 5
置信度 0.82
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Aberrations in neuro-immune, metabolic, and oxidative stress (NIMETOX) pathways are implicated in major depressive disorder (MDD). First-episode simple dysmood disorder (FE-SDMD) without metabolic syndrome offers a unique model to investigate early lipid alter…
pubmed
Sirivatanapa V, Janta P, Almulla AF, Vasupanrajit A 等
2026 Aug 5
置信度 0.82
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Target capture is a common method of generating high throughput DNA sequencing data for phylogenetic reconstruction of species relationships, for which single copy genes are usually most informative. However, a pervasive problem with target capture is that put…
pubmed
Choo LM, de la Estrella M, Schley RJ, Tennant RK 等
2026 Aug 5
置信度 0.82
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Colorectal liver metastases (CRLM) remain the leading cause of death in patients with colorectal cancer and require increasingly sophisticated multidisciplinary management. Recent advances in systemic therapy, molecular profiling, hepatic surgery, liver-direct…
pubmed
Maker AV, Li M, Newhook T, Dulundu E 等
2026 Aug 5
置信度 0.82
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Metabolomics data are currently generated at scale thanks to the evolution of technologies that have led to marked improvements in the number of metabolites detected, spanning all chemical classes. These data are increasingly submitted to public repositories f…
pubmed
Mathé EA, van der Hooft JJ, Chatelaine H, Nothias LF 等
2026 Aug 5
置信度 0.82
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First-trimester ultrasound has evolved beyond basic screening to permit structured neurosonographic assessment of the developing fetal brain. Historically, detailed evaluation of intracranial anatomy was deferred to the mid-trimester, based on assumptions rega…
pubmed
Sharma S, Sanyal A, Khalil A
2026 Jul 29
置信度 0.82
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Klebsiella pneumoniae is a major opportunistic pathogen associated with severe nosocomial infections, and its escalating antimicrobial resistance underscores the urgent need for new therapeutic strategies. Targeting fimbrial adhesin proteins, a critical virule…
pubmed
Islam MB, Supti SJ, Hossain MM, Islam F 等
2026 Jul 25
置信度 0.82
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To overcome HIV-1 drug resistance, we developed a series of novel dual-site NNRTIs by introducing a rigid sp-hybridized alkyne linker, enabling simultaneous occupation of both the NNIBP and NNIAS of HIV-1 RT. Accordingly, 19 exhibited potent antiviral activity…
pubmed
Ji X, Jiang X, Gao H, De Clercq E 等
2026 Jul 31
置信度 0.82
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The ethanol extract of H. capitata stems and flowers were prepared using the hot extraction method with 96% ethanol for chemical composition and biological analysis. GC-MS and LC-MS identified 71 compounds across both extracts. The flower extract contained the…
pubmed
Tien DN, Thanh PP, Huynh CDM, Quoc CP 等
2026 Aug
置信度 0.82
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American Journal of Therapeutics: September 2009 - Volume 16 - Issue 5 - p 466 doi: 10.1097/MJT.0b013e31817c941f
openalex
Vasanth V Ranade
2009-09-01
置信度 0.72
MedicineComputational biologyMEDLINEBiologyBiochemistry
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openalex
1986-01-01
置信度 0.72
Computational biologyBiologyEvolutionary biology
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This chapter highlights the basic principles behind various molecular biology protocols, which should allow multidisciplinary imaging specialists to better understand the techniques. There is a vast diversity of methods in molecular biology. These range from t…
openalex
Julie Héroux, Ahmed M. Gharib
2008-10-13
置信度 0.72
Computational biologyBiologyEvolutionary biology
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The long-awaited Fifth Edition of James D. Watson's classic text, Molecular Biology of the Gene, has been thoroughly revised and is published to coincide with the 50th anniversary of Watson and Crick's paper on the structure of the DNA double-helix. Though com…
openalex
James Dewey Watson
1970-01-01
置信度 0.72
WatsonMolecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic AcidContext (archaeology)BiologyGene
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openalex
Frederick C. Neidhardt, John L. Ingraham
1987-06-01
置信度 0.72
SalmonellaEscherichia coliBiologyMicrobiologyEnterobacteriaceae
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openalex
Philippe Lejeune
1988-06-01
置信度 0.72
Open reading frameBiologyGlycineGeneticsHaplotype
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The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 and PGHS-2; also cyclooxygenases-1 and 2, COX-1 and COX-2) catalyze the committed step in prostaglandin synthesis. PGHS-1 and 2 are of particular interest because they are the major targets of nonstero…
openalex
William L. Smith, David L. DeWitt, R. Michael Garavito
2000-06-01
置信度 0.72
CyclooxygenaseAspirinIsozymeProstaglandinInflammation
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One of the most remarkable aspects of an animal's behavior is the ability to modify that behavior by learning, an ability that reaches its highest form in human beings. For me, learning and memory have proven to be endlessly fascinating mental processes becaus…
openalex
Eric R. Kandel
2001-11-02
置信度 0.72
ConsciousnessCognitive scienceNeuroscienceReductionismPsychology
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openalex
Jean Gautier
1993-04-01
置信度 0.72
BiologyEvolutionary biologyComputational biologyMolecular cell biologyCell biology
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openalex
Paul S. Masters
2006-01-01
置信度 0.72
BiologyCoronavirusSubgenomic mRNAGenomeRNA
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Tetracyclines were discovered in the 1940s and exhibited activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites. They are inexpensive antibiotics, which …
openalex
Ian Chopra, Marilyn C. Roberts
2001-06-01
置信度 0.72
BiologyTetracyclineMicrobiologyEffluxAntibiotic resistance
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Retinoids play an important role in development, differentiation, and homeostasis. The discovery of retinoid receptors belonging to the superfamily of nuclear ligand-activated transcriptional regulators has revolutionized our molecular understanding as to how …
openalex
Pierre Chambon
1996-07-01
置信度 0.72
Retinoid X receptorRetinoic acidNuclear receptorBiologyRetinoid
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The recent sequencing of the entire genomes of Mycoplasma genitalium and M. pneumoniae has attracted considerable attention to the molecular biology of mycoplasmas, the smallest self-replicating organisms. It appears that we are now much closer to the goal of …
openalex
Shmuel Razin, David Yogev, Yehudith Naot
1998-12-01
置信度 0.72
BiologyGenomeGeneAdaptation (eye)Genetics
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openalex
C. René Leemans, Boudewijn J.M. Braakhuis, Ruud H. Brakenhoff
2010-12-16
置信度 0.72
Field cancerizationHead and neck squamous-cell carcinomaHead and neck cancerCancerCancer research
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We like the format of Current Protocols in Molecular Biology , edited by F. M. Ausubel et al. Its looseleaf arrangement allows for great flexibility. Obviously, it permits replacement of sections as new versions or editions are produced. However, it also allow…
openalex
Raymond L. Teplitz
1989-03-03
置信度 0.72
TroubleshootingProtocol (science)Flexibility (engineering)Section (typography)Medicine
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This volume and its companion, Volume 350, are specifically designed to meet the needs of graduate students and postdoctoral students as well as researchers, by providing all the up-to-date methods necessary to study genes in yeast. Procedures are included tha…
openalex
C. P. Kurtzman, Christine Guthrie, Gerald R. Fink
1993-07-01
置信度 0.72
BiologyEvolutionary biologyMolecular geneticsYeastGenetics
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DAMBE (data analysis in molecular biology and evolution) is an integrated software package for converting, manipulating, statistically and graphically describing, and analyzing molecular sequence data with a user-friendly Windows 95/98/2000/NT interface. DAMBE…
openalex
Xuhua Xia
2001-07-01
置信度 0.72
Software packageSoftwareBiologyR packageSoftware evolution
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Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years. No other manual has been so popular, or so influential. Molecular Cloning, Fourth Edition, by the celebrated founding author Joe Sambrook and new co-author, t…
openalex
Joseph Sambrook, Elisabeth Fritsch
1989-01-01
置信度 0.72
Cloning (programming)Computational biologyChromatinCLARITYComputer science
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Prions cause transmissible and genetic neurodegenerative diseases, including scrapie and bovine spongiform encephalopathy of animals and Creutzfeldt-Jakob and Gerstmann-Sträussler-Scheinker diseases of humans. Infectious prion particles are composed largely, i…
openalex
Stanley B. Prusiner
1991-06-14
置信度 0.72
ScrapieNeuropathologyBovine spongiform encephalopathyGene isoformBiology
-
openalex
T. S. Work, E Work
1973-12-01
置信度 0.72
DemethylaseBiogenesisMethyltransferaseTranslation (biology)Biology
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Nuclear receptor coregulators are coactivators or corepressors that are required by nuclear receptors for efficient transcripitonal regulation. In this context, we define coactivators, broadly, as molecules that interact with nuclear receptors and enhance thei…
openalex
Neil J. McKenna, Rainer B. Lanz, Bert W. O’Malley
1999-06-01
置信度 0.72
Transcription coregulatorNuclear receptorNuclear receptor coactivator 1Transcription factorNuclear receptor co-repressor 1
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In this review, our basic and most recent understanding of copper biochemistry and molecular biology for mammals (including humans) is described. Information is provided on the nutritional biochemistry of copper, including food sources, intestinal absorption, …
openalex
Maria C. Linder, Maryam Hazegh-Azam
1996-05-01
置信度 0.72
CopperCopper metabolismCopper deficiencyBiologyMenkes disease
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A scientific consensus is emerging that the origins of adult disease are often found among developmental and biological disruptions occurring during the early years of life. These early experiences can affect adult health in 2 ways--either by cumulative damage…
openalex
Jack P. Shonkoff, W. Thomas Boyce, Bruce S. McEwen
2009-06-02
置信度 0.72
MedicineDiseaseAffect (linguistics)Early childhoodMental health
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openalex
Alexander Rich, Norman Davidson, Linus Pauling
1968-01-01
置信度 0.72
ChemistryComputational biologyBiology
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openalex
1996-11-01
置信度 0.72
Computational biologyBiologyEvolutionary biology
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openalex
H. R. V. Arnstein
1986-02-03
置信度 0.72
WatsonCitationPublishingLibrary scienceComputer science
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openalex
1994-01-01
置信度 0.72
CyanobacteriaBiologyEvolutionary biologyComputational biologyGenetics
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Steroidogenesis entails processes by which cholesterol is converted to biologically active steroid hormones. Whereas most endocrine texts discuss adrenal, ovarian, testicular, placental, and other steroidogenic processes in a gland-specific fashion, steroidoge…
openalex
Walter L. Miller, Richard J. Auchus
2011-02-01
置信度 0.72
Cholesterol side-chain cleavage enzymePregnenoloneHydroxysteroid DehydrogenasesBiologyEnzyme
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openalex
Michael M. C. Lai, D. Cavanagh
1997-01-01
置信度 0.72
BiologyCoronavirusRNAGeneRNA polymerase
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Studies of the molecular genetics, mechanisms of activation and functional connections between general phenylpropanoid metabolism and certain branch pathways in parsley, bean, potato plants and cell cultures
openalex
Klaus Hahlbrock, Dierk Scheel
1989-06-01
置信度 0.72
PhenylpropanoidBiologyMetabolismPhysiologyComputational biology
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STEROID hormones are familiar clinically and physiologically as regulators of physiological processes. Five groups of steroid hormones are generally recognized according to their physiological behavior: mineralocorticoids, which instruct the renal tubules to r…
openalex
Walter L. Miller
1988-08-01
置信度 0.72
SteroidHormoneSteroid hormoneBiologyReceptor
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The goal of this review is to place the exciting advances that have occurred in our understanding of the molecular biology of the types 1, 2, and 3 (D1, D2, and D3, respectively) iodothyronine deiodinases into a biochemical and physiological context. We review…
openalex
Antônio C. Bianco, Domenico Salvatore, Balázs Gereben, Marla J. Berry 等
2002-02-01
置信度 0.72
BiologyBiochemistryComputational biologyPhysiologyCell biology
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Chronic myeloid leukemia (CML) is probably the most extensively studied human malignancy. The discovery of the Philadelphia (Ph) chromosome in 19601 as the first consistent chromosomal abnormality associated with a specific type of leukemia was a breakthrough …
openalex
Michael W. Deininger, John M. Goldman, Junia V. Melo
2000-11-15
置信度 0.72
Myeloid leukemiaBiologyLeukemiaChronic lymphocytic leukemiaMyeloid
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openalex
Philippe Métézeau
1998-05-01
置信度 0.72
BiologyPrometaphaseCancer researchMAPK/ERK pathwayMitosis
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Adult skeletal muscle has a remarkable ability to regenerate following myotrauma. Because adult myofibers are terminally differentiated, the regeneration of skeletal muscle is largely dependent on a small population of resident cells termed satellite cells. Al…
openalex
Thomas J. Hawke, Daniel J. Garry
2001-08-01
置信度 0.72
SatelliteBiologyPopulationSkeletal muscleRegeneration (biology)
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Urease (urea amidohydrolase; EC 3.5.1.5) catalyzes the hydrolysis of urea to yield ammonia and carbamate. The latter compound spontaneously decomposes to yield another molecule of ammonia and carbonic acid. The urease phenotype is widely distributed across the…
openalex
Harry L. T. Mobley, M D Island, Robert P. Hausinger
1995-09-01
置信度 0.72
UreaseProteus mirabilisEnterobacter aerogenesBiochemistryUrea
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openalex
Stanton B. Gelvin, Robbert A. Schilperoort, Desh Pal S. Verma
1990-01-01
置信度 0.72
Computational biologyBiologyEvolutionary biology
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Dengue viruses occur as four antigenically related but distinct serotypes transmitted to humans by Aedes aegypti mosquitoes. These viruses generally cause a benign syndrome, dengue fever, in the American and African tropics, and a severe syndrome, dengue hemor…
openalex
Scott B. Halstead
1988-01-29
置信度 0.72
Dengue feverDengue virusVirologyAntibody-dependent enhancementBiology
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openalex
Gabor M. Rubanyi, Mark A. Polokoff
1994-09-01
置信度 0.72
EndothelinsPathophysiologyMolecular PharmacologyPhysiologyPharmacology
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openalex
2011-03-01
置信度 0.72
BiologyComputational biologyEvolutionary biology
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Until recently, it has been impossible to approach learning with the techniques of cell biology. During the past several years, elementary forms of learning have been analyzed in higher invertebrates. Their nervous systems allow the experimental study of behav…
openalex
Eric R. Kandel, James H. Schwartz
1982-10-29
置信度 0.72
Modulation (music)TransmitterBiologyBiophysicsComputational biology
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The collagen superfamily of proteins now contains at least 19 proteins formally defined as collagens and an additional ten proteins that have collagen-like domains. The most abundant collagens form extracellular fibrils or network-like structures, but the othe…
openalex
Darwin J. Prockop, Kari I. Kivirikko
1995-06-01
置信度 0.72
Drosophila melanogasterBiologyRegulatorCell fate determinationCell biology
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openalex
T. Gichner
1982-09-01
置信度 0.72
YeastSaccharomyces cerevisiaeSaccharomycesBiologyComputational biology