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• MOLECULAR BIOLOGY AND EVOLUTION
  openalex Stéphane Aris-brosou 2012-06-27 置信度 0.72 Computational biologyEvolutionary biologyBiology
• Methods in Chloroplast Molecular Biology
  openalex Barry Halliwell 1983-07-11 置信度 0.72 CitationComputer scienceLibrary scienceInformation retrieval
• Molecular biology of flaviviruses
  openalex Brett D. Lindenbach, Charles M. Rice 2003-01-01 置信度 0.72 BiologyFlavivirusEndocytosisCell biologyViral replication
• The Cell and Molecular Biology of Fracture Healing
  Fracture healing is a complex physiologic process that involves the coordinated participation of several cell types. By using a reproducible model of experimental fracture healing in the rat, it is possible to elucidate the integrated cellular responses that s…
  openalex Thomas A. Einhorn 1998-10-01 置信度 0.72 Endochondral ossificationIntramembranous ossificationBone healingOsteopontinCell biology
• The molecular biology of leaf senescence
  Senescence is a complex, highly regulated, developmental phase in the life of a leaf that results in the co-ordinated degradation of macromolecules and the subsequent mobilization of components to other parts of the plant. The application of molecular biology …
  openalex Vicky Buchanan‐Wollaston 1997-01-01 置信度 0.72 SenescenceBiologyGeneCell biologyFunction (biology)
• Molecular Biology of Bacteriophage T4
  Molecular Biology of Bacteriophage T4 has been the authoritative volume about T4 phage, a model organism instrumental in numerous interdisciplinary scientific discoveries from the 1940s to the present. This book, originally published by ASM Press in 1994, repr…
  openalex Jim D. Karam, John W. Drake 1994-01-01 置信度 0.72 BacteriophageComputational biologyBiologyGeneticsGene
• VMD: Visual molecular dynamics
  openalex William Humphrey, Andrew Dalke, Klaus Schulten 1996-02-01 置信度 0.72 Computer scienceComputer graphics (images)Scripting languageVisualizationRendering (computer graphics)
• The Molecular Biology of Leukocyte Chemoattractant Receptors
  Leukocytes migrate from the blood to sites of inflammation in response to locally produced chemoattractants that activate specific cell surface receptors. The primary structures of leukocyte receptors for N-formyl peptides, C5a, platelet-activating factor, and…
  openalex Philip M. Murphy 1994-04-01 置信度 0.72 BiologyChemotaxisReceptorChemokine receptorInflammation
• The molecular biology of apoptosis.
  All multicellular organisms have mechanisms for killing their own cells, and use physiological cell death for defence, development, homeostasis, and aging. Apoptosis is a morphologically recognizable form of cell death that is implemented by a mechanism that h…
  openalex David L. Vaux, Andreas Strasser 1996-03-19 置信度 0.72 Multicellular organismProgrammed cell deathBiologyCell biologyMechanism (biology)
• The Journal of Steroid Biochemistry and Molecular Biology
  openalex 2011-07-16 置信度 0.72 SolvationChemistryChromatographyPolarHydrogen bond
• Methods in Molecular Biology
  Victor Walter Weedn, MD, JD; Methods in Molecular Biology, American Journal of Clinical Pathology, Volume 111, Issue 2, 1 February 1999, Pages 278–279, https://
  openalex Victor W. Weedn 1999-02-01 置信度 0.72 Computational biologyBiologyEvolutionary biology
• Methods Molecular Biology
  openalex Selvi Bharathavikru, Tatiana Dudnakova 2016-01-01 置信度 0.72 BiologyEvolutionary biologyComputational biology
• Molecular Biology of the Cell
  openalex 1990-01-01 置信度 0.72 Process (computing)Engineering ethicsPerceptionQuality (philosophy)Perspective (graphical)
• Molecular biology of the cell
  openalex J.M.W. Slack 2020-01-01 置信度 0.72 Cell biologyExtracellular matrixBiologyMicrofilamentCell
• Nucleic Acids and Molecular Biology
  openalex Fritz Eckstein, David M.J. Lilley 1994-01-01 置信度 0.72 Nucleic acidBiologyComputational biologyKey (lock)Biochemistry
• Oxidative stress and the molecular biology of antioxidant defenses.
  The oxygen paradox - biochemistry of active oxygen redox regulation by the HIV-1 TAT transcritional factor oxidative damage to DNA and its repair the antioxidative stress in eukaryotes transcriptional regulators of oxidative stress responses oxidative stress, …
  openalex John G. Scandalios 1997-01-01 置信度 0.72 Superoxide dismutaseReactive oxygen speciesOxidative stressBiochemistryBiology
• Biomolecular Simulation: A Computational Microscope for Molecular Biology
  Molecular dynamics simulations capture the behavior of biological macromolecules in full atomic detail, but their computational demands, combined with the challenge of appropriately modeling the relevant physics, have historically restricted their length and a…
  openalex Ron O. Dror, Robert M. Dirks, J.P. Grossman, Huafeng Xu 等 2012-05-11 置信度 0.72 Molecular dynamicsComputer scienceComputational modelNanotechnologyFolding (DSP implementation)
• Molecular biology of dopamine receptors
  openalex David R. Sibley, Frederick J. Monsma 1992-01-01 置信度 0.72 DopamineNeuroscienceDopamine receptorReceptorBiology
• Methods in molecular biology
  openalex Prescott L. Deininger 1991-11-01 置信度 0.72 Computational biologyChemistryBiology
• The molecular biology of the yeast saccharomyces: Life cycle and inheritance
  openalex Fred Sherman 1982-09-01 置信度 0.72 YeastSaccharomyces cerevisiaeBiologyInheritance (genetic algorithm)Genetics
• Current Protocols in Molecular Biology
  openalex Tim Hunt 1989-11-01 置信度 0.72 BiologyCurrent (fluid)Computational biologyEvolutionary biologyEngineering
• Molecular Biology of Aging
  openalex F. Brad Johnson, David Sinclair, Leonard Guarente 1999-01-01 置信度 0.72 BiologyOrganismLife spanLongevitySelection (genetic algorithm)
• Handbook of Biochemistry and Molecular Biology
  Amino Acids, Peptides and Proteins Properties of Amino Acids Data on the Naturally Occurring Amino Acids Structures and Symbols for Synthetic Amino Acids Incorporated Into Synthetic Polypeptides Unnatural Amino Acids for Incorporation into Proteins Properties …
  openalex 2010-05-21 置信度 0.72 Computational biologyBiologyEvolutionary biology
• Molecular Biology of the Androgen Receptor
  Androgen receptor (AR) is a member of the steroid hormone receptor family of molecules. AR primarily is responsible for mediating the physiologic effects of androgens by binding to specific DNA sequences that influence transcription of androgen-responsive gene…
  openalex Edward P. Gelmann 2002-07-01 置信度 0.72 Androgen receptorProstate cancerCoactivatorSteroid hormone receptorCancer research
• The molecular biology of arteriviruses.
  Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, …
  openalex Eric J. Snijder, J. J. M. Meulenberg 1998-05-01 置信度 0.72 BiologyPrincipal (computer security)Clinical microbiologyMicrobiologyComputer science
• Molecular Biology of the Cell
  An introduction to the essentials of the molecular biology of the cell would easily fill this book. Instead I shall focus on one set of problems in molecular biology that Francis Crick, one of the discoverers of the DNA double helix, has termed the central dogm…
  openalex Helmut Schiessel 2013-12-20 置信度 0.72 Computational biologyBiologyEvolutionary biologyZoology
• THE MOLECULAR BIOLOGY OF THE HEPATITIS B VIRUSES
  The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read…
  openalex Don Ganem, Harold Varmus 1987-06-01 置信度 0.72 BiologyDrosophila melanogasterRegulatorCell biologyMelanogaster
• Molecular biology of the cell
  openalex J. B. Gurdon 1983-10-01 置信度 0.72 Computational biologyMolecular cell biologyBiologyCell biologyChemistry
• Computational Molecular Biology
  In one of the first major texts in the emerging field of computational molecular biology, Pavel Pevzner covers a broad range of algorithmic and combinatorial topics and shows how they are connected to molecular biology and to biotechnology. The book has a subs…
  openalex Pavel A. Pevzner 2000-08-17 置信度 0.72 Computational biologyComputer scienceEvolutionary biologyBiology
• Progress in Nucleic Acid Research and Molecular Biology
  This book is organized under the following headings: Transposable elements in Drosophilia; Regulation of gene expression; Structure and function of repetitive and unusual sequences; Retroviruses; Molecular analysis of chromosomal translocation and gene inserti…
  openalex Waldo E. Cohn, Kivie Moldave 2001-09-07 置信度 0.72 Transposable elementBiologyNucleic acidGeneticsGene
• Guide to yeast genetics and molecular biology
  openalex Viesturs Simanis 1992-04-01 置信度 0.72 BiologyYeastEvolutionary biologyComputational biologyGenetics
• DAMBE5: A Comprehensive Software Package for Data Analysis in Molecular Biology and Evolution
  Since its first release in 2001 as mainly a software package for phylogenetic analysis, data analysis for molecular biology and evolution (DAMBE) has gained many new functions that may be classified into six categories: 1) sequence retrieval, editing, manipula…
  openalex Xuhua Xia 2013-04-05 置信度 0.72 BiologyPhylogenetic treePhylogeneticsMaximum parsimonyGenBank
• Introduction to Computational Molecular Biology
  Preface 1. Basic Concepts of Molecular Biology 2. Strings, Graphs, and Algorithms 3. Sequence Comparison and Database Search 4. Fragment Assembly of DNA 5. Physical Mapping of DNA 6. Phylogenetic Trees 7. Genome Rearrangements 8. Molecular Structure Prediction…
  openalex João Carlos Setúbal, João Meidânis 1997-01-16 置信度 0.72 Phylogenetic treeComputational biologyGenomeIndex (typography)DNA sequencing
• Plant hormones : physiology, biochemistry and molecular biology
  A: Introduction. 1. The plant hormones: Their nature, occurrence, and functions P.J. Davies. 2. The plant hormone concept: Concentration, and sensitivity and transport P.J. Davies. B: Hormone Synthesis and Metabolism. 1. Auxin biosynthesis and metabolism R.S. …
  openalex Peter J. Davies 1995-01-01 置信度 0.72 AuxinGibberellinBiosynthesisAbscisic acidCytokinin
• G‐Quartets 40 Years Later: From 5′‐GMP to Molecular Biology and Supramolecular Chemistry
  Molecular self-assembly is central to many processes in both biology and supramolecular chemistry. The G-quartet, a hydrogen-bonded macrocycle formed by cation-templated assembly of guanosine, was first identified in 1962 as the basis for the aggregation of 5'…
  openalex Jeffery T. Davis 2004-01-27 置信度 0.72 Supramolecular chemistryGuanosineNanotechnologyChemistryOligonucleotide
• Biochemistry and molecular biology of fishes
  openalex 1994-01-01 置信度 0.72 BiologyComputational biologyEvolutionary biologyZoology
• Molecular Biology of the Pituitary Gonadotropins
  THE pituitary gonadotropins, LH and FSH, play a central role in the mammalian reproductive process. Synthesized in the gonadotropes of the pituitary, the gonadotropins bind to receptors in the gonads leading to effects on steroidogenesis and gametogenesis (Fig…
  openalex Soheyla Gharib, Margaret E. Wierman, Margaret A. Shupnik, William W. Chin 1990-02-01 置信度 0.72 BiologyGonadotropinGonadotropic cellGametogenesisSecretion
• Molecular Biology of Neuroblastoma
  UNLABELLED: PURPOSE AND RESULTS: Neuroblastoma, the most common solid extracranial neoplasm in children, is remarkable for its clinical heterogeneity. Complex patterns of genetic abnormalities interact to determine the clinical phenotype. The molecular biology…
  openalex John M. Maris, Katherine K. Matthay 1999-07-01 置信度 0.72 NeuroblastomaCancer researchOncogeneBiologyChromosomal translocation
• MOLECULAR BIOLOGY OF THE LysR FAMILY OF TRANSCRIPTIONAL REGULATORS
  The LysR family is composed of > 50 similar-sized, autoregulatory transcriptional regulators (LTTRs) that apparently evolved from a distant ancestor into subfamilies found in diverse prokaryotic genera. In response to different coinducers, LTTRs activate diver…
  openalex Mark A. Schell 1993-10-01 置信度 0.72 Coronavirus disease 2019 (COVID-19)BiologyBetacoronavirusCoronavirusSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
• Energy flow in biological system: Bioenergy transduction of V1-ATPase molecular rotary motor from E. hirae
  We classify research fields in biology into those on flows of materials, energy, and information. As a representative energy transducing machinery in biology, our research target, V1-ATPase from a bacterium Enterococcus hirae, a typical molecular rotary motor …
  arxiv Ichiro Yamato, Takeshi Murata, Andrei Khrennikov 2017-05-27T21:31:53Z 置信度 0.78 q-bio.BMquant-ph
• Bayesian uncertainty analysis for complex systems biology models: emulation, global parameter searches and evaluation of gene functions
  Background: Many mathematical models have now been employed across every area of systems biology. These models increasingly involve large numbers of unknown parameters, have complex structure which can result in substantial evaluation time relative to the need…
  arxiv Ian Vernon, Junli Liu, Michael Goldstein, James Rowe 等 2016-07-21T15:10:57Z 置信度 0.78 q-bio.MNq-bio.CBq-bio.QMstat.APstat.ME
• Molecular recognition of the environment and mechanisms of the origin of species in quantum-like modeling of evolution
  A review of the mechanisms of speciation is performed. The mechanisms of the evolution of species, taking into account the feedback of the state of the environment and mechanisms of the emergence of complexity, are considered. It is shown that these mechanisms…
  arxiv Alexey V. Melkikh, Alexey V. Melkikh, Andrei Khrennikov 2017-05-27T20:42:00Z 置信度 0.78 q-bio.PEquant-ph
• A U-band survey of brown dwarfs in the Taurus Molecular Cloud with the XMM-Newton Optical/UV Monitor
  We aim to characterize the U-band variability of young brown dwarfs in the Taurus Molecular Cloud and discuss its origin. We used the XMM-Newton Extended Survey of the Taurus Molecular Cloud, where a sample of 11 young bona fide brown dwarfs (spectral type lat…
  arxiv Nicolas Grosso, Marc Audard, Jérôme Bouvier, Kevin R. Briggs 等 2006-09-01T13:24:57Z 置信度 0.78 astro-ph
• From Physics to Biology by Extending Criticality and Symmetry Breakings
  Symmetries play a major role in physics, in particular since the work by E. Noether and H. Weyl in the first half of last century. Herein, we briefly review their role by recalling how symmetry changes allow to conceptually move from classical to relativistic …
  arxiv Giuseppe Longo, Maël Montévil 2011-03-09T17:08:48Z 置信度 0.78 q-bio.OT
• A Molecular Implementation of the Least Mean Squares Estimator
  In order to function reliably, synthetic molecular circuits require mechanisms that allow them to adapt to environmental disturbances. Least mean squares (LMS) schemes, such as commonly encountered in signal processing and control, provide a powerful means to …
  arxiv Christoph Zechner, Mustafa Khammash 2017-01-03T08:55:23Z 置信度 0.78 q-bio.MN
• Reverse Engineering of Molecular Networks from a Common Combinatorial Approach
  The understanding of molecular cell biology requires insight into the structure and dynamics of networks that are made up of thousands of interacting molecules of DNA, RNA, proteins, metabolites, and other components. One of the central goals of systems biolog…
  arxiv Bhaskar DasGupta, Paola Vera-Licona, Eduardo Sontag 2011-02-24T04:56:37Z 置信度 0.78 q-bio.MNcs.CEq-bio.QM
• Methods of Information Theory and Algorithmic Complexity for Network Biology
  We survey and introduce concepts and tools located at the intersection of information theory and network biology. We show that Shannon's information entropy, compressibility and algorithmic complexity quantify different local and global aspects of synthetic an…
  arxiv Hector Zenil, Narsis A. Kiani, Jesper Tegnér 2014-01-15T14:34:00Z 置信度 0.78 q-bio.MNq-bio.QM
• The use of information theory in evolutionary biology
  Information is a key concept in evolutionary biology. Information is stored in biological organism's genomes, and used to generate the organism as well as to maintain and control it. Information is also "that which evolves". When a population adapts to a local…
  arxiv Christoph Adami 2011-12-16T15:59:35Z 置信度 0.78 q-bio.PEcs.ITq-bio.NC
• Universally Sloppy Parameter Sensitivities in Systems Biology
  Quantitative computational models play an increasingly important role in modern biology. Such models typically involve many free parameters, and assigning their values is often a substantial obstacle to model development. Directly measuring \emph{in vivo} bioc…
  arxiv Ryan N. Gutenkunst, Joshua J. Waterfall, Fergal P. Casey, Kevin S. Brown 等 2007-01-24T19:12:58Z 置信度 0.78 q-bio.QMq-bio.MN
• Bayesian Parameter Estimation for Dynamical Models in Systems Biology
  Dynamical systems modeling, particularly via systems of ordinary differential equations, has been used to effectively capture the temporal behavior of different biochemical components in signal transduction networks. Despite the recent advances in experimental…
  arxiv Nathaniel J. Linden, Boris Kramer, Padmini Rangamani 2022-04-11T21:24:10Z 置信度 0.78 q-bio.QMq-bio.MN
• Functional Synthetic Biology
  Synthetic biologists have made great progress over the past decade in developing methods for modular assembly of genetic sequences and in engineering biological systems with a wide variety of functions in various contexts and organisms. However, current paradi…
  arxiv Ibrahim Aldulijan, Jacob Beal, Sonja Billerbeck, Jeff Bouffard 等 2022-07-01T16:44:29Z 置信度 0.78 q-bio.QM
• The prospects of quantum computing in computational molecular biology
  Quantum computers can in principle solve certain problems exponentially more quickly than their classical counterparts. We have not yet reached the advent of useful quantum computation, but when we do, it will affect nearly all scientific disciplines. In this …
  arxiv Carlos Outeiral, Martin Strahm, Jiye Shi, Garrett M. Morris 等 2020-05-26T15:18:05Z 置信度 0.78 quant-phq-bio.BMq-bio.GNq-bio.QMstat.ML
• Blind source separation methods for deconvolution of complex signals in cancer biology
  Two blind source separation methods (Independent Component Analysis and Non-negative Matrix Factorization), developed initially for signal processing in engineering, found recently a number of applications in analysis of large-scale data in molecular biology. …
  arxiv Andrei Zinovyev, Ulykbek Kairov, Tatiana Karpenyuk, Erlan Ramanculov 2013-01-11T23:47:16Z 置信度 0.78 q-bio.QMcs.CEq-bio.GN
• Approximation of Intractable Likelihood Functions in Systems Biology via Normalizing Flows
  Systems biology relies on mathematical models that often involve complex and intractable likelihood functions, posing challenges for efficient inference and model selection. Generative models, such as normalizing flows, have shown remarkable ability in approxi…
  arxiv Vincent D. Zaballa, Elliot E. Hui 2023-12-04T23:10:56Z 置信度 0.78 q-bio.QM
• Virtual-organism toy-model as a tool to develop bioinformatics approaches of Systems Biology for medical-target discovery
  Systems Biology has emerged in the last years as a new holistic approach based on the global understanding of cells instead of only being focused on their individual parts (genes or proteins), to better understand the complexity of human cells. Since the Syste…
  arxiv Albert Pujol, Raquel Valls, Vesna Radovanovic, Emre Guney 等 2013-01-11T16:00:30Z 置信度 0.78 q-bio.MNq-bio.CB
• Information theory in molecular biology
  This article introduces the physics of information in the context of molecular biology and genomics. Entropy and information, the two central concepts of Shannon's theory of information and communication, are often confused with each other but play transparent…
  arxiv Christoph Adami 2004-05-05T20:52:48Z 置信度 0.78 q-bio.BMq-bio.PE
• Physics of liquid crystals in cell biology
  The last decade has witnessed a rapid growth in understanding of the pivotal roles of mechanical stresses and physical forces in cell biology. As a result an integrated view of cell biology is evolving, where genetic and molecular features are scrutinized hand…
  arxiv Amin Doostmohammadi, Benoit Ladoux 2021-10-07T06:42:11Z 置信度 0.78 cond-mat.softcond-mat.mtrl-sciphysics.bio-ph
• Hydration of Clays at the Molecular Scale: The Promising Perspective of Classical Density Functional Theory
  We report here how the hydration of complex surfaces can be efficiently studied thanks to recent advances in classical molecular density functional theory. This is illustrated on the example of the pyrophylite clay. After presenting the most recent advances, w…
  arxiv Guillaume Jeanmairet, Virginie Marry, Maximilien Levesque, Benjamin Rotenberg 等 2014-02-11T18:02:17Z 置信度 0.78 physics.chem-ph
• Synthetic Biology in Leishmaniasis: Design,simulation and validation of constructed Genetic circuit
  Building circuits and studying their behavior in cells is a major goal of systems and synthetic biology. Synthetic biology enables the precise control of cellular states for systems studies, the discovery of novel parts, control strategies, and interactions fo…
  arxiv Dixita Limbachiya 2013-04-01T12:32:52Z 置信度 0.78 q-bio.MN
• A systems biology approach to COVID-19 progression in a population
  A number of models in mathematical epidemiology have been developed to account for control measures such as vaccination or quarantine. However, COVID-19 has brought unprecedented social distancing measures, with a challenge on how to include these in a manner …
  arxiv Magdalena Djordjevic, Andjela Rodic, Igor Salom, Dusan Zigic 等 2020-05-19T17:57:41Z 置信度 0.78 q-bio.PEphysics.soc-ph
• Biology and Physics
  This article frames the relation between biology and physics by characterizing the former as a subdiscipline rather than a special case of the latter. To do this, we posit biological physics as the science of living matter in contrast to classic biophysics, th…
  arxiv Stuart A. Newman, Sahotra Sarkar 2026-03-11T19:00:05Z 置信度 0.78 physics.bio-phcond-mat.softq-bio.TO
• Perspectives on theory at the interface of physics and biology
  Theoretical physics is the search for simple and universal mathematical descriptions of the natural world. In contrast, much of modern biology is an exploration of the complexity and diversity of life. For many, this contrast is prima facie evidence that theor…
  arxiv William Bialek 2015-12-30T14:47:40Z 置信度 0.78 physics.bio-phcond-mat.dis-nnphysics.hist-phq-bio.QM
• From Prediction to Simulation: AlphaFold 3 as a Differentiable Framework for Structural Biology
  AlphaFold 3 represents a transformative advancement in computational biology, enhancing protein structure prediction through novel multi-scale transformer architectures, biologically informed cross-attention mechanisms, and geometry-aware optimization strategi…
  arxiv Alireza Abbaszadeh, Armita Shahlaee 2025-08-25T19:49:28Z 置信度 0.78 q-bio.BMcs.LG
• Physical Principles of Quantum Biology
  This technical monograph provides a comprehensive overview of the field of quantum biology. It approaches quantum biology from a physical perspective with core quantum mechanical concepts presented foremost to provide a theoretical foundation for the field. An…
  arxiv Nathan S. Babcock, Brandy N. Babcock 2025-03-14T17:12:25Z 置信度 0.78 physics.bio-phq-bio.BMq-bio.CBq-bio.SCq-bio.TO
• Deciphering neural circuits for Caenorhabditis elegans behavior by computations and perturbations to genome and connectome
  {\it Caenorhabditis elegans} nematode worms are the only animals with the known detailed neural connectivity diagram, well characterized genomics, and relatively simple quantifiable behavioral output. With this in mind, many researchers view this animal as the…
  arxiv Jan Karbowski 2019-10-16T16:17:33Z 置信度 0.78 q-bio.NCq-bio.GNq-bio.QM
• How to obtain thermostatted ring polymer molecular dynamics from exact quantum dynamics and when to use it
  We obtain thermostatted ring polymer molecular dynamics (TRPMD) from exact quantum dynamics via Matsubara dynamics, a recently-derived form of linearization which conserves the quantum Boltzmann distribution. Performing a contour integral in the complex quantu…
  arxiv Timothy J. H. Hele 2015-08-24T14:17:56Z 置信度 0.78 physics.chem-phquant-ph
• Integration of Omics Data and Systems Biology Modeling: Effect of Cyclosporine A on the Nrf2 Pathway in Human Renal Kidneys Cells
  In a recent paper, Wilmes et al. demonstrated a qualitative integration of omics data streams to gain a mechanistic understanding of cyclosporine A toxicity. One of their major conclusions was that cyclosporine A strongly activates the nuclear factor (erythroi…
  arxiv Jérémy Hamon, Paul Jennings, Frederic Y. Bois 2013-12-17T12:28:58Z 置信度 0.78 q-bio.QMq-bio.MN
• TEDDY: A Family Of Foundation Models For Understanding Single Cell Biology
  Understanding the biological mechanisms of disease is crucial for medicine, and in particular, for drug discovery. AI-powered analysis of genome-scale biological data holds great potential in this regard. The increasing availability of single-cell RNA sequenci…
  arxiv Alexis Chevalier, Soumya Ghosh, Urvi Awasthi, James Watkins 等 2025-03-05T13:24:57Z 置信度 0.78 cs.LGq-bio.QM
• Disordered vortex matter out of equilibrium: a Langevin molecular dynamics study
  We discuss the use of Langevin molecular dynamics in the investigation of the non-equilibrium properties of disordered vortex matter. Our special focus is set on values of system parameters that are realistic for disordered high-$T_c$ superconductors such as Y…
  arxiv Hiba Assi, Harshwardhan Chaturvedi, Ulrich Dobramysl, Michel Pleimling 等 2015-09-07T23:44:50Z 置信度 0.78 cond-mat.stat-mechcond-mat.supr-con
• Toward a general theory for the universality and scaling in critical thermal responses in biology
  We developed a theory showing that under appropriate normalizations and rescalings, temperature response curves show a remarkably regular behavior and follow a general, universal law. The impressive universality of temperature response curves remained hidden d…
  arxiv Jose Ignacio Arroyo, Pablo A. Marquet, Christopher P. Kempes, Geoffrey West 2025-03-07T04:19:25Z 置信度 0.78 q-bio.OT
• Concerns regarding the deterioration of objectivity in molecular biology
  Scientific objectivity was not a problem in the early days of molecular biology. However, relativism seems to have invaded some areas of the field, damaging the objectivity of its analyses. This review reports on the status of this issue by investigating a num…
  arxiv Tomokazu Konishi 2018-07-10T02:54:49Z 置信度 0.78 q-bio.OT
• BioPreDyn-bench: benchmark problems for kinetic modelling in systems biology
  Dynamic modelling is one of the cornerstones of systems biology. Many research efforts are currently being invested in the development and exploitation of large-scale kinetic models. The associated problems of parameter estimation (model calibration) and optim…
  arxiv Alejandro F Villaverde, David Henriques, Kieran Smallbone, Sophia Bongard 等 2014-07-22T13:31:05Z 置信度 0.78 q-bio.QMcs.CEq-bio.MN
• Optimal Design of a Molecular Recognizer: Molecular Recognition as a Bayesian Signal Detection Problem
  Numerous biological functions-such as enzymatic catalysis, the immune response system, and the DNA-protein regulatory network-rely on the ability of molecules to specifically recognize target molecules within a large pool of similar competitors in a noisy bioc…
  arxiv Yonatan Savir, Tsvi Tlusty 2010-07-26T18:19:13Z 置信度 0.78 q-bio.MNcs.ITphysics.bio-ph
• For principled model fitting in mathematical biology
  The mathematical models used to capture features of complex, biological systems are typically non-linear, meaning that there are no generally valid simple relationships between their outputs and the data that might be used to validate them. This invalidates th…
  arxiv Thomas House 2014-04-21T20:32:28Z 置信度 0.78 q-bio.QM
• How to address cellular heterogeneity by distribution biology
  Cellular heterogeneity is an immanent property of biological systems that covers very different aspects of life ranging from genetic diversity to cell-to-cell variability driven by stochastic molecular interactions, and noise induced cell differentiation. Here…
  arxiv Niko Komin, Alexander Skupin 2021-09-13T16:46:58Z 置信度 0.78 q-bio.QM
• Cancer systems biology in the genome sequencing era: Part 1, dissecting and modeling of tumor clones and their networks
  Recent tumor genome sequencing confirmed that one tumor often consists of multiple cell subpopulations (clones) which bear different, but related, genetic profiles such as mutation and copy number variation profiles. Thus far, one tumor has been viewed as a wh…
  arxiv Edwin Wang, Jinfeng Zou, Naif Zaman, Lenore K. Beitel 等 2014-09-06T02:38:11Z 置信度 0.78 q-bio.MN
• Minimal coarse-grained models for molecular self-organisation in biology
  The molecular machinery of life is largely created via self-organisation of individual molecules into functional assemblies. Minimal coarse-grained models, where a whole macromolecule is represented by a small number of particles, can be of great value in iden…
  arxiv Anne E. Hafner, Johannes Krausser, Anđela Šarić 2019-06-21T22:53:08Z 置信度 0.78 physics.bio-phcond-mat.soft
• Cancer systems biology in the genome sequencing era: Part 2, evolutionary dynamics of tumor clonal networks and drug resistance
  A tumor often consists of multiple cell subpopulations (clones). Current chemo-treatments often target one clone of a tumor. Although the drug kills that clone, other clones overtake it and the tumor reoccurs. Genome sequencing and computational analysis allow…
  arxiv Edwin Wang, Jinfeng Zou, Naif Zaman, Lenore K. Beitel 等 2014-09-06T02:48:08Z 置信度 0.78 q-bio.MN
• Simulations meet Machine Learning in Structural Biology
  Classical molecular dynamics (MD) simulations will be able to reach sampling in the second timescale within five years, producing petabytes of simulation data at current force field accuracy. Notwithstanding this, MD will still be in the regime of low-throughp…
  arxiv Adrià Pérez, Gerard Martínez-Rosell, Gianni De Fabritiis 2018-10-19T10:39:23Z 置信度 0.78 q-bio.BMphysics.comp-ph
• Inverse problems for coupled nonlocal nonlinear systems arising in mathematical biology
  In this paper, we propose and study several inverse problems of determining unknown parameters in nonlocal nonlinear coupled PDE systems, including the potentials, nonlinear interaction functions and time-fractional orders. In these coupled systems, we enforce…
  arxiv Ming-Hui Ding, Hongyu Liu, Catharine W. K. Lo 2024-07-22T15:20:04Z 置信度 0.78 math.APq-bio.PE
• Graph Theory and Networks in Biology
  In this paper, we present a survey of the use of graph theoretical techniques in Biology. In particular, we discuss recent work on identifying and modelling the structure of bio-molecular networks, as well as the application of centrality measures to interacti…
  arxiv Oliver Mason, Mark Verwoerd 2006-04-06T14:55:34Z 置信度 0.78 q-bio.MNq-bio.QM
• Giulio Fermi's contributions to biophysics and molecular biology
  This paper presents a comprehensive list of the scientific articles of Giulio Fermi (1936-1997), son of the Italian-American physicist Enrico Fermi, published between 1962 and 1997. The initial research activity of Giulio was concerned with virology and biolog…
  arxiv Fabio Pichierri 2018-01-07T05:40:55Z 置信度 0.78 physics.hist-phphysics.bio-phq-bio.BM
• Athena: Modular CAM/CAD Software for Synthetic Biology
  Synthetic biology is the engineering of cellular networks. It combines principles of engineering and the knowledge of biological networks to program the behavior of cells. Computational modeling techniques in conjunction with molecular biology techniques have …
  arxiv Deepak Chandran, Frank T. Bergmann, Herbert M. Sauro 2009-02-16T03:31:27Z 置信度 0.78 q-bio.QMq-bio.MN
• MicroRNA Systems Biology
  Recently, microRNAs (miRNAs) have emerged as central posttranscriptional regulators of gene expression. miRNAs regulate many key biological processes, including cell growth, death, development and differentiation. This discovery is challenging the central dogm…
  arxiv Edwin Wang 2007-12-20T21:02:28Z 置信度 0.78 q-bio.MNq-bio.GN
• Context in Synthetic Biology: Memory Effects of Environments with Mono-molecular Reactions
  Synthetic biology aims at designing modular genetic circuits that can be assembled according to the desired function. When embedded in a cell, a circuit module becomes a small subnetwork within a larger environmental network, and its dynamics is therefore affe…
  arxiv Johannes Falk, Leo Bronstein, Maleen Hanst, Barbara Drossel 等 2018-09-25T15:39:23Z 置信度 0.78 q-bio.MNcond-mat.stat-mechphysics.bio-phphysics.chem-ph
• Machine Learning Harnesses Molecular Dynamics to Discover New $μ$ Opioid Chemotypes
  Computational chemists typically assay drug candidates by virtually screening compounds against crystal structures of a protein despite the fact that some targets, like the $μ$ Opioid Receptor and other members of the GPCR family, traverse many non-crystallogr…
  arxiv Evan N. Feinberg, Amir Barati Farimani, Rajendra Uprety, Amanda Hunkele 等 2018-03-12T19:32:21Z 置信度 0.78 q-bio.BMstat.ML
• Atomic Biology, Electrostatics, and Ionic Channels
  I believe an atomic biology is needed to supplement present day molecular biology, if we are to design and understand proteins, as well as define, make, and use them. Topics in the paper are molecular biology and atomic biology. Electrodiffusion in the open ch…
  arxiv R. S. Eisenberg 2008-07-04T10:35:06Z 置信度 0.78 q-bio.BMphysics.bio-phq-bio.QM
• Molecular Cloud Biology
  Some astrobiological models suggest that molecular clouds may serve as habitats for extraterrestrial life. This study reviews recent theoretical work addressing the physical and biochemical prerequisites for life in such environments, with particular focus on …
  arxiv Lei Feng 2025-02-23T15:37:45Z 置信度 0.78 physics.pop-phastro-ph.EPastro-ph.SRphysics.bio-ph
• TIM3 as a therapeutic target in anaplastic thyroid cancer: upregulation in M2-like macrophages induced by tumor microenvironment-derived TGFβ1.
  Thyroid cancer (TC) is the most common endocrine malignancy. While papillary thyroid cancer (PTC) generally has a favorable prognosis, anaplastic thyroid cancer (ATC) is rare but highly aggressive, with limited treatment options, highlighting the urgent need f…
  pubmed Jaroszewski A, Choi YS, Hellriegel F, Zhang W 等 2026 Aug 5 置信度 0.82
• RIOK2 Promotes Clear Cell Renal Cell Carcinoma Progression Through Cell Cycle Regulation.
  Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of kidney cancer and is frequently associated with poor clinical outcomes. Ribosome biogenesis, which is upregulated in many malignancies, plays a key role in tumor proliferation. Right open…
  pubmed Shikuma H, Goto K, Shimo A, Hatayama T 等 2026 Aug 置信度 0.82
• Development and Characterization of a Structurally Supportive of Hybrid PLGA Decellularized ECM Biomembrane for Ocular Progenitor Cell Anchorage and Epithelial Repair.
  Degenerative ocular diseases are among the leading causes of visual impairment worldwide and require innovative therapeutic approaches capable of promoting tissue regeneration. In this context, biomaterial-based cell therapies have emerged as promising alterna…
  pubmed Ungaratti AKG, de Lima AP, Santos JA, de Melo PL 等 2026 Aug 置信度 0.82
• Harnessing Repurposed Drugs to Enhance Temozolomide Efficacy in Glioblastoma.
  Glioblastoma (GB) is the most aggressive primary malignant brain tumor in adults and remains associated with poor survival despite surgical resection followed by radiotherapy and temozolomide (TMZ) chemotherapy. Intrinsic and acquired resistance to TMZ, includ…
  pubmed Nakhaei A, Taghavi A, Afshari AR, Davoudi F 等 2026 Aug 置信度 0.82
• Redefining Expertise: Preparing the Next Generation of Physicians Caring for Patients with Inborn Errors of Immunity.
  pubmed Somech R, Grunebaum E 2026 Aug 置信度 0.82
• Beyond DNA damage: 3D tumor models and the integrin mechanobiology of radioresistance.
  Despite major advances in radiation delivery, clinical outcomes remain constrained by tumor biology rather than technology. Conventional radiobiology has relied on reductionist two-dimensional (2D) systems that fail to capture the spatial, mechanical, and mult…
  pubmed Cordes N 2026 Aug 5 置信度 0.82
• Rhobot-Screen: an integrated robotic platform for functional screening of rhodopsin variants.
  Rhodopsins are photoreceptive membrane proteins widely used as optogenetic tools in basic research and medical applications, and extensive mutational studies have been performed to improve or modify their functional properties. Recently, in the broader field o…
  pubmed Nagata T, Konno M, Hashimoto DR, Inoue K 2026 Aug 6 置信度 0.82
• Zafirlukast Exacerbates Behavioral Seizure Activity and Blood-Brain Barrier Disruption Despite Modestly Reducing Neuronal Injury Markers in a PTZ-Induced Early Epileptogenesis Mouse Model.
  Epilepsy is one of the most prevalent neurological disorders worldwide, and approximately 25% of patients remain refractory to pharmacological treatment. Blood-brain barrier (BBB) disruption and reactive gliosis are key mechanisms implicated in early epileptog…
  pubmed Gorgulu V, Tomruk CS, Ergun P, Ozdil B 等 2026 Aug 5 置信度 0.82
• Hippocampal CA3 connectomics reveals a gradient of mossy fiber inputs and selective feedforward inhibition onto pyramidal cells.
  The mossy fiber (MF) connections to pyramidal cells in hippocampal CA3 are thought to participate in pattern separation, pattern completion and memory encoding, yet no large-scale neuronal wiring diagram exists for these connections. We assembled a 3D electron…
  pubmed Zheng Z, Park C, Hammerschmith EW, Lu R 等 2026 Aug 5 置信度 0.82
• BRD4 recruitment into HP1 condensates desilences transcription without erasure of repressive chromatin.
  How genes are desilenced without erasure of repressive chromatin is a poorly understood phenomenon. A dominant mode of repression occurs through methylation of lysine 9 of histone H3 (H3K9me3), a mark that engages heterochromatin protein 1 (HP1) to drive chrom…
  pubmed Brandon CJ, Robinson-Thiewes S, Kaulage M, Rosikiewicz W 等 2026 Aug 5 置信度 0.82
• Reimagining reproductive futures : Speculative Design as an Artistic-Public Thought Experiment.
  pubmed Li BX, Raz A, Minari J 2026 Aug 5 置信度 0.82
• Fc-optimized GITR antibody enhances a CD4 T cell-dendritic cell crosstalk to promote antitumor immunity.
  Targeting the stimulatory immune checkpoint glucocorticoid-induced TNFR-related protein (GITR) using agonistic monoclonal antibodies (mAbs) is a promising strategy for cancer immunotherapy that activates effector T cells and eliminates regulatory T cells. The …
  pubmed Avraham Y, Barth N, Yair Bar-On T, Toval B 等 2026 Aug 5 置信度 0.82