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• Tumoral extracellular vesicles and particles reprogram interstitial macrophages in the lung to promote vascular permeability and metastasis.
  The mechanisms by which tumor-derived extracellular vesicles and particles (EVPs) promote vascular permeability during premetastatic niche formation remain unclear. Here, we show that tumor EVPs rapidly induce vascular leakiness within 1 h of administra…
  pubmed Dror S, Wortzel I, Lucotti S, Seo Y 等 2026 Aug 5 置信度 0.82
• Palmitate promotes liver metastases by decreasing neutrophil antitumour behaviour.
  Liver metastases are frequent and challenging to treat owing to the liver's metabolically active and immune-tolerant environment. However, how cancer cells exploit nutrient availability in the liver to evade immune surveillance remains unknown. Here we show th…
  pubmed Vandekeere A, Fernández-García J, Peng-Winkler Y, Martín Pérez M 等 2026 Aug 5 置信度 0.82
• MDM2 binds and suppresses RNA polymerase III to restrain the innate immune response to cytosolic DNA.
  The oncoprotein MDM2 is widely recognized as the principal negative regulator of p53, thereby controlling the expression of numerous RNA polymerase II (Pol II)-dependent genes involved in cell cycle arrest and apoptosis. Beyond this canonical role, MDM2 also e…
  pubmed Weber S, Manzini V, Dietrich H, Schotte H 等 2026 Aug 6 置信度 0.82
• Towards implementation of continuous biologically relevant light measurements at the bedside in the Neonatal Intensive Care Unit.
  Preterm infants, when admitted to the Neonatal Intensive Care Unit (NICU), are exposed to an environment that lacks a robust 24-hour light-dark cycle, potentially disrupting the input to their circadian system and developmental outcomes. Accurate quantificatio…
  pubmed Bos R, Belgers S, Dudink J, de Kort Y 等 2026 Aug 5 置信度 0.82
• ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer.
  Phenotypic plasticity is a hallmark of cancer 1 ; however the molecular switches required for cell-fate reprogramming are poorly understood. During intestinal wound-healing and colorectal cancer (CRC) metastasis, differentiated cells can dynamically dedifferen…
  pubmed Jiang Q, Raghavan MS, Rodriguez AM, Lallo M 等 2026 Aug 5 置信度 0.82
• Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours.
  Understanding how adverse life events trigger stress-related behavioural changes remains an unresolved challenge. The amygdala is integral to emotion and stress responses 1 and comprises astrocytes, neurons and other cells. Here we show that amy…
  pubmed Pelaz SG, Mitsui K, Kolosowska N, Fritch H 等 2026 Aug 5 置信度 0.82
• A cholinergic hub in the nucleus accumbens gates opioid-reward learning.
  Beneficial and maladaptive opioid effects are difficult to dissociate 1-3 , partly because dopamine signalling contributes to both these effect types 4-13 . Here we show that associative opioid-reward learning can be blocked even under conditions that elevate …
  pubmed Yousefzadeh SA, Yan H, Kwak SH, Oh Y 等 2026 Aug 5 置信度 0.82
• A tumour-derived organoid biobank maps cancer gene dependencies.
  Cancer cell lines remain foundational for research and drug discovery, yet they incompletely capture tumour diversity, lack linked patient context, and have undergone adaptation to culture. Tumour organoids are three-dimensional cultures derived from patient t…
  pubmed Herranz-Ors C, Bhosle SG, Beck AE, Gilbert JGR 等 2026 Aug 5 置信度 0.82
• A compendium of next-generation patient-derived models for diverse cancers.
  The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2-4 . Recent technologies …
  pubmed ElHarouni D, Al-Jazrawe M, Choi S, Dede M 等 2026 Aug 5 置信度 0.82
• A dependency map enhanced with next-generation 3D cancer models.
  Despite advances in precision oncology, effective personalized treatments are still lacking for most patients with cancer 1 . The Cancer Dependency Map (DepMap) accelerates this field by systematically identifying cancer vulnerabilities in diverse preclinical …
  pubmed Neiswender JV, Maffa S, Brenan L, ElHarouni D 等 2026 Aug 5 置信度 0.82
• Engineered lipid nanoparticles for in vivo and durable editing of haematopoietic stem cells within humanized mice.
  In vivo genetic engineering of haematopoietic stem and progenitor cells (HSPCs) holds the potential to revolutionize the treatment landscape for numerous diseases. However, despite its transformative potential, it remains hindered by the difficulty in efficien…
  pubmed Du J, Luo Z, Xie D, Chen Y 等 2026 Aug 5 置信度 0.82
• Piperazine linked chitosan schiff base nanoparticles as a novel antibiofilm and antibacterial strategy against clinically relevant pathogens.
  The development of multifunctional antimicrobial materials capable of targeting both planktonic bacteria and biofilm-associated infections remains a critical challenge in combating antimicrobial resistance. In this study, a novel piperazine-linked chitosan Sch…
  pubmed Soliman MM, Bayoumy AE, Hamed AA, Gabre RM 等 2026 Aug 6 置信度 0.82
• Correction: Enhanced accumulation of anticancer compounds in C. roseus hairy root cultures through elicitation and precursor feeding.
  pubmed Rady MR, Mabrouk DM, El-Minisy AM, Ibrahim MM 2026 Aug 5 置信度 0.82
• Structure of human cytoplasmic Pol II complex explains global transcription repression by GDOWN1.
  RNA polymerase II (Pol II) is a 12-subunit enzyme crucial for gene transcription in the nucleus. However, its assembly in the cytoplasm, nuclear import, and nuclear function of assembly factors remain poorly understood. Here, we isolated Pol II from the cytopl…
  pubmed Schmitzová J, Zhan Y, Rengachari S, Grabbe F 等 2026 Aug 5 置信度 0.82
• Structural basis for the contribution of latent TGFβ binding protein to TGFβ latency and activation.
  Transforming growth factor-β (TGFβ) is a potent cytokine that controls all aspects of cellular behavior. TGFβ is secreted in complex with its prodomain and latent TGFβ-binding protein-1 (LTBP1), forming the large latent complex (LLC), w…
  pubmed Biggin GR, Snee M, Xiao YB, Smedley C 等 2026 Aug 5 置信度 0.82
• Selenium-Binding Protein 1 Deficiency Inhibits the Antitumor Immunity of Dendritic Cells.
  Selenium-binding protein 1 (SELENBP1) correlates positively with the prognosis of patients with colitis and colon cancer. SELENBP1-deficient dendritic cells (DCs) promote regulatory T cell differentiation and exert direct immunomodulatory functions. This study…
  pubmed Han S, Li Y, Meng J, Dai J 等 2026 Aug 5 置信度 0.82
• Association between the uric acid-to-albumin ratio and mortality in hyperuricemia: a nationwide cohort study.
  The prognostic value of uric acid-to-albumin ratio (UAR) for mortality among patients with hyperuricemia remains unclear. This study aimed to investigate its association with all-cause and cardiovascular mortality.
  pubmed Tang J, Li X, Mo S, Chen W 等 2026 Jul 17 置信度 0.82
• HuR degradation reveals dependencies in BRAF-driven cancers.
  Targeting RNA-binding proteins has been shown to be challenging due to the absence of druggable pockets. Recently, Lu et al. identified a molecular glue capable of degrading HuR and suppressing BRAF-mutant colorectal cancer. These findings offer a promising th…
  pubmed Siordia IR, Brody JR, Dixon DA 2026 Aug 5 置信度 0.82
• A Streamlined Workflow for Purkinje Cell Labeling and High-Resolution Analyses of Dendrites and Spines in Mice.
  Cerebellar Purkinje cells (PCs) exhibit a unique and highly complex dendritic architecture, which plays a crucial role in integrating synaptic inputs and shaping their physiological properties. However, fine morphological investigation of PCs at the single-cel…
  pubmed Tan X, Niu S, Bai M, Megagiannis P 等 2026 Aug 5 置信度 0.82
• Breathing immunity into in vitro lung models.
  The human lung hosts a highly specialised immune microenvironment responsible for defence, repair and responses to pathogens and environmental insults. Animal models insufficiently recapitulate human-specific immune pathways, limiting translational insight int…
  pubmed Doryab A, Heydarian M, Bryant C, Conway Morris A 2026 Aug 5 置信度 0.82
• Amylin: A Multi-Functional Pancreatic Hormone-A Review.
  Amylin is a pancreatic beta-cell hormone that sits at a systems hub connecting key aspects of energy metabolism. Amylin physiologically controls satiation, slows gastric emptying and limits postprandial glucagon release, while its actions also link homeostatic…
  pubmed Le Foll C, Lutz TA 2026 Aug 5 置信度 0.82
• Structural Characterization of New 8,17-Epoxybriarane Diterpenoids from the Octocoral Briareum stechei.
  An encrusting, algae-associated octocoral, Briareum stechei, afforded three 8,17-epoxybriarane diterpenoids, including the known compound briaexcavatolide B (1) and two previously undescribed analogues, briastecholides Q (2) and R (3). The absolute configurati…
  pubmed Liu YH, Hsu CK, Zheng LG, Chien SY 等 2026 置信度 0.82
• Challenges in Designing Clinical Trials to Test New Drugs in the Pregnant and Breastfeeding Woman.
  Until recently, pregnant or lactating women were systematically excluded from drug development. Currently, the ethical consensus is that women who are pregnant or lactating need to be involved in drug development. The rich experience of drug development in HIV…
  pubmed Olagunju A, Waitt C, Turner MA, Navaratnam K 2026 Sep 置信度 0.82
• C1q dependency of retinal ganglion cell death in blast-mediated traumatic brain injury.
  Traumatic brain injury is a widespread health concern that annually affects millions of people worldwide, with blast-mediated TBI (bTBI) being of particular relevance to military personnel and civilians in war zones. Current treatments primarily target symptom…
  pubmed Hedberg-Buenz A, Dutca LM, Boehme NA, Mann AR 等 2026 Aug 5 置信度 0.82
• Lifetime imaging reveals long-distance non-neural bioelectric patterns on timescales from seconds to hours.
  Translating the bioelectric code remains one of the core challenges to widespread biomedical translation of bioelectric interventions, as well as a better evolutionary understanding of how developmental ionic signaling evolved to become the basis of neural int…
  pubmed McMillen P, Levin M 2026 Aug 5 置信度 0.82
• Rare severe Gardner-Diamond syndrome-like presentation with hG5c_2 neutrophils.
  pubmed Fan S, Cui W, Zhao D, Shi M 等 2026 Aug 5 置信度 0.82
• Determinants of Protein Phosphatase 1β substrate specificity for MyPhoNE motif-containing proteins.
  Phosphoprotein phosphatase 1 (PP1) forms holoenzymes composed of a catalytic subunit (PP1c) and one or two of over 200 regulatory subunits (PP1Rs). Humans express four conserved PP1c isoforms: PP1cα, PP1cβ/δ, and splice variants PP1cγ1 …
  pubmed Poimenidou G, Ragusa M, Peti W, Kettenbach AN 2026 Aug 5 置信度 0.82
• An integrated automated pipeline for cloning, transient expression, and purification augmenting the plant cell pack platform for biopharmaceutical screening.
  Biopharmaceuticals, particularly monoclonal antibodies (mAbs), are a rapidly expanding class of therapeutics and have benefitted from high-throughput screening (HTS) strategies for protein engineering. Obtaining such complex biopharmaceuticals from plants migh…
  pubmed Schulze M, Opdensteinen P, Albert S, Gabriel N 等 2026 Aug 5 置信度 0.82
• Catestatin improves cardiac function during ischemia/reperfusion via activation of ATP-sensitive potassium channel in rats.
  This study aimed to investigate the cardioprotective effects of Catestatin (CST) against ischemia/reperfusion (I/R) injury and the potential involvement of ATP-sensitive potassium (K ATP ) channels.
  pubmed Chen H, Zhang Y, Zhang J, Guo H 等 2026 Aug 5 置信度 0.82
• Bombyx mori lncRNA Unc-89-AS1 contributes to viral proliferation through modulating cell apoptosis.
  Long noncoding RNAs (lncRNAs) have been demonstrated to participate in apoptosis and host-virus interactions. Apoptosis is a host mechanism for defending against virus invasion. Bombyx mori nucleopolyhedrovirus (BmNPV) is one of the primary pathogens infecting…
  pubmed Jia X, Cai M, Xiao Y, Gao Y 等 2026 Aug 5 置信度 0.82
• cGAS-STING signaling in acute myeloid leukemia: biology, pathophysiology and therapeutic implications.
  The 'cyclic GMP-AMP synthase-Stimulator of interferon genes' (cGAS-STING) pathway is a key component of the innate immune machinery, that detects the presence of cytosolic dsDNA and initiates type I interferon-driven inflammation, resulting in downstream immun…
  pubmed Bhowmik S, Ghosh S, Sengupta A 2026 Aug 5 置信度 0.82
• Comparative De Novo Transcriptomic Analysis of Leishmania tropica Provides Insights into Translation, Metabolism, and Virulence-Related Pathways Potentially Associated with Leishmania RNA Virus 2 Status.
  Leishmania tropica is an intracellular parasite belonging to the phylum Euglenozoa; it exhibits significant clinical heterogeneity and is spread by sandfly vectors through anthroponotic or zoonotic transmission. Leishmania RNA virus, a viral endosymbiont belon…
  pubmed Nalçaci M, Özbel Y, Mermer A, Töz S 2026 Aug 5 置信度 0.82
• Idiopathic inflammatory myopathies as a damage-data-endotype continuum: A roadmap to precision trials and computable biomarkers.
  Idiopathic inflammatory myopathies (IIM) are heterogeneous immune-mediated diseases characterized by muscle inflammation that coexists with variable trajectories of lung, skin, cardiac involvement, and malignancy association. Although modern classification cri…
  pubmed Gangemi S, Gammeri L, Longhi E, Bogdanos D 等 2026 Aug 5 置信度 0.82
• Cascading Attrition of In Vivo CAR-T Therapy: From Systemic Delivery Failure to Functional Collapse.
  Ex vivo chimeric antigen receptor (CAR)-T cell therapy demonstrates strong efficacy but remains limited by high costs and lengthy manufacturing. In vivo in situ reprogramming provides a scalable "off-the-shelf" alternative by directly engineering endogenous T …
  pubmed Rao H, Xu S, Chen J, Guo Z 2026 Aug 5 置信度 0.82
• Real-world data on once or twice daily radiotherapy and the effect of age in patients with limited-stage small cell lung cancer.
  We aimed to assess acute toxicity and overall survival (OS) in patients with limited-stage small cell lung cancer (LS-SCLC) who received concurrent thoracic chemoradiotherapy using either once-daily (OD) or twice-a-day (BID) radiotherapy and compare these outc…
  pubmed Bosch F, Damhuis R, Peters M, van Bockel LW 等 2026 Aug 5 置信度 0.82
• Largemouth bass virus infection subverts immune-redox homeostasis in zebrafish and is associated with coordinated suppression of NF-κB and Nrf2 signaling.
  From lower vertebrates to higher mammals, oxidative stress and inflammatory responses form a tightly regulated homeostatic network, yet the virus-specific mechanisms that coordinate these processes remain unclear. Here, we investigated this question using Larg…
  pubmed Guan L, Zhang X, Yu T, Liu Y 等 2026 Aug 5 置信度 0.82
• Targeted Transcriptomic Profiling Identifies Biomarkers and Molecular Features Associated With Immunotherapy Response in Classic Hodgkin Lymphoma.
  Classic Hodgkin lymphoma (CHL) is a highly curable disease. However, a subset of patients develops relapsed/refractory disease, underscoring the need for predictors of treatment response. Although immune-checkpoint inhibitors have improved outcomes, many patie…
  pubmed Hamana L, Marques-Piubelli ML, Wei L, Khan K 等 2026 Aug 5 置信度 0.82
• Life beyond 6,000 genes: From sequence to synthesis in a post-genomics era.
  The publication of the Saccharomyces cerevisiae genome sequence thirty years ago marked a defining shift in modern biology, establishing yeast as the first fully sequenced eukaryotic model cell. Access to a complete reference genome has catalysed a renaissance…
  pubmed Walker RSK, Archer E, Erpf P, Paulsen IT 等 2026 Aug 5 置信度 0.82
• α-Satellite RNA maintains centromeric cohesion through R-loops.
  Tandemly repeated satellite DNAs provide the building blocks for centromeres, but whether and how their transcripts regulate chromosome segregation remain poorly defined. Here, we show that human α-satellite RNAs (α-SatRNAs) are required for mainta…
  pubmed Yang L, Zhang Q, Teng Z, Moran E 等 2026 Aug 5 置信度 0.82
• Stepwise DNA-unwinding gates TnpB genome-editing activity.
  TnpB is a compact RNA-guided endonuclease and an evolutionary ancestor of CRISPR-Cas12 that offers a promising platform for genome engineering. However, the genome-editing activity of TnpBs remains limited, and its underlying determinants are poorly understood…
  pubmed Zhou Z, Saffarian-Deemyad I, Shi H, Weiss T 等 2026 Aug 5 置信度 0.82
• Increased signaling of the Neanderthal growth hormone receptor.
  Neanderthals had a robust build and distinctive skeletal features. The hypothalamic-pituitary-somatotropic (HPS) axis, with growth hormone (GH) as a central signaling molecule, plays a crucial role in regulating skeletal development. To explore whether Neander…
  pubmed Kanis P, Berreiter M, Sieme D, Wootton O 等 2026 Aug 5 置信度 0.82
• Corpora amylacea profiling reveals disease stage and brain region-specific alterations in glycogen metabolism in Alzheimer's disease patient brains.
  Increasing evidence indicates that shifts in brain polysaccharide metabolism can influence the progression of multiple neurodegenerative diseases. Here, we profile corpora amylacea (CA) in 230 postmortem human brains, revealing significantly higher densities i…
  pubmed Villareal JAB, Bathe T, Rosa A, Sharma RV 等 2026 Aug 5 置信度 0.82
• Simultaneous, real-time tracking of many neuromodulatory signals with multiplexed optical recording of sensors on a micro-endoscope.
  Dozens of extracellular molecules jointly impact a given brain cell, yet we lack methods to simultaneously record many such signals in real time. We developed a probe to track ten or more neuropeptide and neuromodulator concentrations using spatial multiplexin…
  pubmed Kalugin PN, Soden PA, Massengill CI, Amsalem O 等 2026 Aug 5 置信度 0.82
• Spatial biology reveals altered macrophage states in immunosuppressed non-melanoma skin cancer.
  Immunosuppressed patients with non-melanoma skin cancer experience worse clinical outcomes, yet the tumor immune microenvironment associated with systemic immunosuppression remains incompletely defined. Using integrated single-cell, spatial transcriptomic, mul…
  pubmed Naara S, Kochat V, Rao X, Arslan E 等 2026 Aug 5 置信度 0.82
• Polystyrene microplastics impair skeletal development in zebrafish: Biphasic toxicity and comparison with marine medaka.
  Microplastic pollution poses a growing threat to aquatic ecosystems, yet its impacts on skeletal development in fish remain poorly understood. This study investigated the toxic effects of polystyrene microplastics (PS MPs) on skeletal development in zebrafish …
  pubmed Liao J, Qin Y, Yuan Y, Xu S 等 2026 Aug 5 置信度 0.82
• Litigating the hype: the Lung Health Institute class action and its implications.
  The recent Lung Institute class action lawsuit is used as an example of patient-initiated lawsuits regarding unproven "stem cell" interventions. Current regulatory considerations for administration and advertisement of cell therapies are contrasted to gaps tha…
  pubmed Alonzo M, Grilley BJ, Weiss DJ, Ikonomou L 2026 May 3 置信度 0.82
• A rosemary (Salvia rosmarinus Spenn) extract promotes oxidative stress tolerance in Arabidopsis thaliana.
  Oxidative stress is a consequence of many abiotic stresses, and developing environmentally friendly, efficient biostimulant strategies to mitigate stress is of paramount importance to modern agriculture. Here, we report that treatment of Arabidopsis thaliana w…
  pubmed Feuli C, Kabwe E, García L, Petrov V 等 2026 Aug 3 置信度 0.82
• Integrated assessment of biocontrol potential and genome analysis of endophytic Bacillus velezensis MGL-B1 against mango stem-end rot.
  Mango stem-end rot is a globally significant postharvest disease that severely threatens the mango industry, primarily caused by Botryosphaeria dothidea. However, information on biocontrol agents targeting this pathogen in mango remains limited. In this study,…
  pubmed Jian W, Yao Q, Zeng Y, Chen Y 等 2026 Jul 31 置信度 0.82
• Targeting a novel metabolic vulnerability of non-small cell lung cancer to fatty acid oxidation surmounts chemoresistance.
  Non-small cell lung cancer (NSCLC) patients treated with platinum drugs develop chemoresistance. C/EBPβ has alternative translational LAP and LIP isoforms which impact cancer chemoresistance by modulating ABC efflux transporter expression and activity. D…
  pubmed Fontana S, Belisario DC, Giannotta C, Alessandri L 等 2026 Aug 2 置信度 0.82
• Molecular recognition in plant root endosymbiosis.
  Root endosymbiosis is one of the most intimate types of plant-microbe interactions in which a symbiont is hosted within a living plant cell. In this symbiosis, nitrogen-fixing bacteria and arbuscular mycorrhizal fungi support plant nutrient provisioning in exc…
  pubmed Fougner-Økland T, Spezzati M, Parys K 2026 Aug 置信度 0.82
• Elastase and myeloperoxidase participate in neutrophil extracellular trap release stimulated by SARS-CoV-2.
  COVID-19 is a disease triggered by SARS-CoV-2 and some individuals develop a severe form that can progress to multiple organ failure. Neutrophils have been described as responsible for the release of neutrophil extracellular traps (NETs). The role of the elast…
  pubmed Silva JDC, Almeida C, Silva BMS, Bonfim BS 等 2026 Aug 4 置信度 0.82
• Assessing Vancomycin-Formyl Peptide Conjugate Binding to the Surface of Resistant Staphylococcus aureus via Flow Cytometry.
  Staphylococcus aureus strains have emerged with resistance mechanisms that reduce the efficacy of last resort antibiotics and evade the immune system. One strategy to combat antimicrobial resistance is to modulate host immunity to eliminate infections more eff…
  pubmed Hoo WPY, Gullick J, Leung RF, Fulcher AJ 等 2026 Aug 14 置信度 0.82
• Toward an Understanding of the Mechanistic Differences Between the Hydroxylating and Desaturating Pyridoxal 5'-Phosphate-Dependent L-Arginine Oxidases.
  Pyridoxal-5'-phosphate (PLP)-dependent L-arginine oxidases (PDAOs) catalyze 4-electron oxidations of L-arginine in the context of secondary metabolite biosynthesis. PDAOs are separated into two classes based on whether they hydroxylate or desaturate L-arginine…
  pubmed Melkonian TR, Vuksanovic N, Han L, Uttke ZA 等 2026 Aug 14 置信度 0.82
• PES-8, a ZP-like protein, is required for Cytoskeletal Organization and Contractility in the C. elegans Spermatheca.
  Proper regulation of contraction and relaxation in biological tubes is essential for organismal function. In C. elegans , the spermatheca, composed of smooth muscle-like cells, undergoes repeated stretching and contraction as oocytes pass through. Here we desc…
  pubmed Sadeghian F, Cram EJ 2026 Aug 5 置信度 0.82
• Tet Trim-Away: A conditional rapid protein degradation system for Tetrahymena thermophila.
  Tetrahymena thermophila is a ciliated protist that has played pivotal roles in biological discovery. Functional studies of Tetrahymena proteins have largely relied on gene knockouts. Because protein depletion upon knockout typically spans multiple cell cycles,…
  pubmed Dholakia GL, Stemm-Wolf AJ, Anzar A, Turkewitz AP 等 2026 Aug 5 置信度 0.82
• Centriolar satellites regulate CEP350 mRNA stability and centrosome amplification.
  Messenger RNAs (mRNAs) accumulate at centrosomes in mitosis and interphase, yet the mechanisms governing their localization and their functional significance remain poorly understood. Here, we identify a centriolar satellite - RNA-binding protein (RBP) pathway…
  pubmed Martinez A, Pearson CG 2026 Aug 5 置信度 0.82
• Quantitative comparison of PI(3,5)P(2) biosensors reveals SnxA is the most sensitive and unbiased.
  PI(3,5)P 2 is an endosomal lipid whose depletion is associated with a variety of pathologies such as neurodegenerative diseases. However, studying this lipid in physiological and disease models has been difficult due to the scarcity of the lipid and the lack o…
  pubmed Swayhoover T, Weckerly CC, Hammond GRV 2026 Aug 5 置信度 0.82
• Clinical Significance of SOX2 Promoter Methylation in Breast Cancer Prognosis.
  Introduction SOX2 , a key pluripotency gene, plays a central role in breast cancer stem cell (BCSC) biology, driving tumor aggressiveness. Although SOX2 dysregulation has been widely studied across various cancers, its specific regulatory mechanisms in breast …
  pubmed Maqbool F, Ahamed A, Anwar S, Fatima M 等 2026 Jan-Dec 置信度 0.82
• Vorasidenib improves response to subsequent chemoradiation in a genetically engineered mouse model of IDH-mutant glioma.
  The mutant isocitrate dehydrogenase 1/2 inhibitor (mIDHi) vorasidenib was recently incorporated into clinical treatment guidelines for IDH-mutant gliomas, although its impact on chemoradiation is unclear. Specifically, it is unknown whether upfront mIDHi expos…
  pubmed Shi DD, Calvo Fernández E, Puliyappadamba VT, Lanman TA 等 2026 Aug 5 置信度 0.82
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