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• A VERSATILE LIBRARY OF TETRACYCLINE-INDUCIBLE AND REPRESSIBLE VECTORS FOR FINE-TUNED GENE EXPRESSION
  ABSTRACT The genus Mycobacterium is increasingly recognized as a major clinical concern due to diseases such as tuberculosis, along with the emergence of antimicrobial-resistant strains, underscoring the urgent need for advanced genetic tools to study mycobact…
  crossref Akshay V Nair, Shinto James, Vikas Jain 2026-05-02T05:10:16Z 置信度 0.70
• Synthetic Biology Strategies for Activating Cryptic BGCs in <i>Streptomyces</i> : Engineering Native and Synthetic Promoters for Antibiotic Discovery
  crossref Riyanka Shil, Veilumuthu Pattapulavar, Sathiyabama Ramanujam, Saranyadevi Subburaj 等 2026-01-03T00:34:45Z 置信度 0.70
• Characterization of Synthetic Gene Circuits with Absolute Quantification in Continuous Culture
  Despite rapid improvements in our ability to engineer novel biological systems, robust biodesign of synthetic gene circuits-networks of synthetic genes regulating each other-has been limited by a lack of standardized methods for understanding and reproducibly …
  crossref Scott B. Stacey, Ting An Lee, Olivia Gallup, Eszter Csibra 等 2026-07-08T22:17:12Z 置信度 0.70
• Prioritization Strategy and Engineering Optimization for Paclitaxel Biosynthesis: From Pathway Analysis to Synthetic Biology
  Paclitaxel, one of the most widely used natural anticancer drugs in clinical treatment, plays a significant role across medicine, public health, and even the economic sphere. However, the traditional extraction method relies too heavily on Taxus spp., resultin…
  crossref Junkang Lin 2026-06-10T07:57:23Z 置信度 0.70
• Mechanistic tradeoffs between local and long-range signaling activity in natural and synthetic morphogens
  Hedgehog family morphogens present an interesting paradox: despite being hydrophobic due to dual-lipid modifications, they form spatial concentration gradients that are highly conserved and essential for many aspects of metazoan development. Using live-cell si…
  crossref Gavin Schlissel, Anders S. Hansen, Pulin Li 2026-02-10T01:05:18Z 置信度 0.70
• Covalent tumor anchoring spatially orchestrates antitumor immunity
  ABSTRACT Protein immunotherapies can elicit potent tumor rejection, but reversible target engagement, incomplete tumor retention, and systemic leakage often erode spatial control. Here, we develop covalently anchored tumor immunotherapeutic proteins (CATIPs), …
  crossref Qingke Li, Hongfei Chen, Pan Zhang, Li Cao 等 2026-05-15T04:00:18Z 置信度 0.70
• Endogenous cAMP elevation regulates proteostasis networks to integrate stress signaling, metabolic reprogramming, and immune defense in Arabidopsis.
  The second messenger 3',5'-cyclic adenosine monophosphate (cAMP) serves as a critical transducer of environmental signals in plants, yet its systems-level integration of stress-responsive networks remains poorly characterized. To elucidate how cAMP signaling o…
  pubmed Babar U, Zhang H, Xu R 2026 Jun 置信度 0.82
• Ozone as a Next-Generation Sterilization Process in Tissue Engineering and Regenerative Medicine: Critically Bridging Product Stability, Safety and Clinical Translation.
  Tissue engineering and regenerative medicine (TERM) rely on advanced biomaterials and scaffolds that require strict sterilization without sacrificing their structural and functional properties. Conventional sterilization methods, including steam, ethylene oxid…
  pubmed Manglaris C, Karipidou N, Manolakaki E, Koummati E 等 2026 Jun 11 置信度 0.82
• Design and Implementation of a Blue-Light-Controlled Gene-Switch System.
  Synthetic biology seeks to build predictable, programmable biological systems. We developed a blue-light-inducible T7RNAP system with dual-input regulation to enable precise spatiotemporal gene control, which is vital for biomanufacturing, therapy, and microbi…
  pubmed Li C, Shi Y, Jiang X, Zhao B 等 2026 Jun 10 置信度 0.82
• Construction and Evaluation of High-Efficiency Tannase-Producing Strains.
  The low production efficiency of tannase and the insufficient utilization of high-tannin feed resources form the research background and research significance of this study. In this experiment, the tannase sequence TanLpl from Lactiplantibacillus plantarum ATC…
  pubmed Gao Y, Hu C, Wei W, Urjid D 等 2026 May 30 置信度 0.82
• Native Bacteria Associated with Mushroom Cultivation Promote Mushroom Growth Through Multiple Mechanisms.
  Some microorganisms present in the cultivation environment serve as biocontrol agents and contribute to enhanced mushroom production. However, the native bacteria naturally associated with commercial cultivation bags of Pleurotus ostreatus , as well as their g…
  pubmed Li K, Zhao H, Meng D, Zhang X 等 2026 May 24 置信度 0.82
• Microalgae as Novel Food Resources: Technological Breakthroughs, Application Bottlenecks, and Future Pathways.
  Global population growth and the demand for sustainable food systems have pushed microalgae into the spotlight as promising novel food resources. They are rich in protein, omega-3 fatty acids, and bioactive pigments including astaxanthin and phycocyanin. Unlik…
  pubmed Zhang X, Chen W, Chen H 2026 置信度 0.82
• Maternal Microbial Reservoirs Are Associated with Early Bacterial and Archaeal Community Assembly in Neonatal Hu Lambs.
  Early-life microbial community assembly is important for gastrointestinal development, immune maturation, and feed utilization in young ruminants, but the maternal reservoirs associated with neonatal lamb gut microbial profiles remain insufficiently defined. T…
  pubmed Huang B, Mao C, Xu T, Ji S 等 2026 Jun 17 置信度 0.82
• Systematic Evaluation of Signal Peptide-Driven Protein Secretion in the Fast-Growing Cyanobacterium Synechococcus sp. PCC 11901.
  The fast-growing cyanobacterium Synechococcus sp. PCC 11901 is emerging as a promising chassis for photosynthetic biomanufacturing. Here we report recombinant protein production in PCC 11901 via signal peptide-mediated secretion, enabling direct recovery of ta…
  pubmed Moreno-Cabezuelo JÁ, Booth A, Lin D, Gathani K 等 2026 置信度 0.82
• Revealing the Hydrophobic Interactions between Annular Lipids and Transmembrane Peptides via Photo-Tagging and Mass Spectrometry.
  Annular lipids, which constitute the lipid layer directly interacting with protein transmembrane domains, are essential for maintaining protein structure and function. Nevertheless, the analysis of the dynamic and weak noncovalent interactions between annular …
  pubmed Zhao J, Dong X, Wan W, Qiao L 等 2026 Jul 8 置信度 0.82
• Role of a Synonymous Mutation at Codon 178 in P1 That Attenuates Potato Virus Y-Induced Tobacco Vein Necrosis and Its Application for Expressing Human Interferon.
  Plant virus-based vectors are gaining significant attention as bioreactors for recombinant protein production due to their broad host range, robust expression levels and cost-effectiveness; however, their practical utility is frequently constrained by severe v…
  pubmed Liu DG, Wang YY, Zhu Q, Huang XW 等 2026 Jun 置信度 0.82
• A PAMP-Inducible Caffeic Acid O-Methyltransferase Gene (EcCOMT49) From Finger Millet Attenuates Bax-Triggered Cell Death by Regulating ROS Homeostasis.
  Caffeic acid O-methyltransferases (COMTs) contribute to phenylpropanoid metabolism and have emerging roles in reactive oxygen species (ROS) regulation during plant stress. Finger millet (Eleusine coracana), a resilient cereal, harbours diverse COMT isoforms, a…
  pubmed Kumar V, Chakarpani K, Yadav M, Sonowal K 等 2026 Jul-Aug 置信度 0.82
• Critical Path to First-in-Human Batches of ChAdOx Vectors, Including for Emergency Response.
  Background: Adenovirus-vectored vaccines played an important role in the global response to SARS-CoV-2. Adenovirus platforms have many advantages including a simple and readily transferred manufacturing process, low cost, and thermostability. Speed of producti…
  pubmed Peralta Alvarez MP, Hussain S, Magri A, Vieira J 等 2026 Jun 4 置信度 0.82
• Advances in GelMA Hydrogel-Enabled Angiogenic-Osteogenic Coupling: From Structural Programming to Exogenous Cue Synergy.
  Vascular-osteogenic coupling plays a central regulatory role in bone regeneration, but it is frequently impaired under pathological conditions, including aging, ischemia, and chronic inflammation, which compromises efficient bone repair. Gelatin methacryloyl (…
  pubmed Hu C, Zhang M, Jiang H, Qu Y 等 2026 Jun 6 置信度 0.82
• Synergistic Enhancement of Straw Hydrolysis and Lactic Acid Production in Talaromyces pinophilus Through Combined Random Mutagenesis and Plasmid Reconstruction.
  Lignocellulosic biorefineries are limited by the high cost of cellulolytic enzymes. Consolidated bioprocessing (CBP), which integrates saccharification and fermentation in one step, offers a solution to this challenge. In this study, a cellulase-hyperproducing…
  pubmed Yue S, Li Y, Li P, Zeng J 等 2026 Jun 3 置信度 0.82
• Multi-Enzyme Cascade Reaction of Crude Enzyme Strategy for the Economical and Efficient Bioconversion of Rebaudioside A to Rebaudioside M.
  Rebaudioside M (Reb M) is a natural sweetener with high sweetness, low caloric content, and an excellent sensory profile. However, it's extremely low natural abundance in Stevia rebaudiana leaves renders conventional extraction processes costly, inefficient, a…
  pubmed Huang Y, Ge Y, Zhang M, Zhou W 2026 Jun 置信度 0.82
• [Artificial enzyme design for the biosynthesis of chiral ketones].
  Efficient asymmetric synthesis of chiral ketones is a significant challenge in green biomanufacturing. To address the scarcity of natural secondary amine enzymes and the insufficient activation capability of existing artificial enzymes towards ketone substrate…
  pubmed Sun Z, Xu H, Zhou Z 2026 Jun 25 置信度 0.82
• [Mining of ancestral lipases and enzymatic synthesis of amides].
  The amide bond plays a crucial role in the synthesis of proteins, pharmaceuticals, and agrochemicals. It is particularly significant in the pharmaceutical field as a key structural unit in many drugs, such as afatinib (an anticancer drug), teriflunomide (used …
  pubmed Zhang X, Xu G 2026 Jun 25 置信度 0.82
• [Functional characteristics of the SACE_2701-2702 transport system in Saccharopolyspora erythraea and its impact on erythromycin biosynthesis].
  For antibiotic-producing microorganisms, enhancing product efflux not only alleviates the toxic effects of antibiotics on the cell factory but also represents a powerful metabolic engineering strategy for increasing yields. This study aims to elucidate the mol…
  pubmed Lv Z, Ding Y, Li N, Feng X 等 2026 Jun 25 置信度 0.82
• [Advances in glutathione biosynthesis and industrialization].
  Glutathione is a thiol tripeptide widely existing in animals, plants, and microorganisms, showing antioxidant and detoxifying functions. It is used in the multiple fields such as pharmaceuticals, food, cosmetics, and feed additives. In recent years, with the r…
  pubmed Lin C, Yang X, Chen Y, Zheng R 等 2026 置信度 0.82
• Deciphering the role of soil temperature dynamics in modulating cotton (Gossypium hirsutum L.) growth, yield, and resource efficiency under variable sowing dates.
  Sowing period has a considerable effect on cotton productivity by regulating the use of thermal resources, but its effect on various soils depth layers has not been properly measured. The current study investigated the impacts of date sowing on cotton yield, c…
  pubmed Khan H, Collela Be M, Khan Z, Han Y 等 2026 Jun 24 置信度 0.82
• Coimmobilized Pyridoxal 5'-Phosphate and Aminotransferase in a Hydrogen-Bonded Organic Framework for Sustainable Synthesis of Sitagliptin.
  Aminotransferases (ATAs), essential enzymes for the synthesis of chiral amine drugs, play a crucial role in the synthesis of sitagliptin. The catalytic process of ATAs relies on the effective synergistic action of the cofactor pyridoxal 5'-phosphate (PLP). How…
  pubmed Zhang S, Liu S, Yu L, Sun Y 2026 Jul 7 置信度 0.82
• Generation of Cellular Biofactories for the Scalable Production of Surface-Engineered Extracellular Vesicles via CRISPR Genome Editing.
  Extracellular vesicles (EVs) are versatile biological nanoparticles with applications in therapeutics, diagnostics, and biotechnology. Current production methods relying on transient transfection or chemical conjugation suffer from high variability, limited sc…
  pubmed Kawai-Harada Y, You S, Scarborough T, Siraj N 等 2026 置信度 0.82
• Engineering an Extremely Hybrid PKS for Adipic Acid Production.
  Polyketide synthases (PKSs) are modular enzymes with exceptional potential as biocatalysts for producing non-native compounds. Here, we report the first PKS-based pathway for adipic acid (AA), an industrial monomer for nylon production, by engineering one of t…
  pubmed Klass SH, Wang Z, Lanclos N, Wesselkamper M 等 2026 Jul 17 置信度 0.82
• AI-Derived Smart Microneedle Systems for Advanced Wound Management: From Intelligent Sensing to Closed-Loop Therapy.
  As the primary barrier between the human body and the external environment, skin is susceptible to damage from multiple factors, making wound healing management a significant clinical challenge. Traditional wound care approaches mainly rely on passive dressing…
  pubmed Chen X, Zhou K, Li X, Wu T 等 2026 Jun 置信度 0.82
• Random integration and high-throughput screening forging robust microbial cell factories.
  Microbial cell factories are central to sustainable biomanufacturing. This Forum article discusses how random integration, coupled with high-throughput screening (HTS) and AI, enables the mapping of favorable genomic loci to guide targeted strain engineering. …
  pubmed Hua J, Song P, Wu J, Liu Z 2026 Jun 23 置信度 0.82
• Leveraging Biokinetic Knowledge Priors for Data-Scarce Bioprocess Modeling
  While deep learning has accelerated drug discovery, its impact on biomanufacturing has been considerably more limited. The reason is data scarcity. Bioreactor experiments are high-cost, take days to weeks, and are rarely shared in public form, leaving each res…
  datacite Hur, Kyunghoon, Jeon, Eunjung, Kim, Hyun Woo, Lee, Gyubok 等 2026 置信度 0.66 Machine Learning (cs.LG)Artificial Intelligence (cs.AI)FOS: Computer and information sciences
• Developing a lactate sensing and controlling system in CHO cells
  Chinese Hamster Ovary (CHO) cells are the preferred host for the biomanufacturing of monoclonal antibodies (mAb), which represent more than 50% of the FDA approved biopharmaceuticals. Cultured CHO cells show enhanced glycolysis during exponential cell growth, …
  datacite Royuela, Alex Arrese-Igor 2026 置信度 0.66 Lactate sensingCHO cellsMonoclonal antibodies productionGenetic "sense-and-control" systemCytosolic pyruvate
• Tri-valorization of methanol in a single bioreactor: co-production of enzyme, chemical, and single-cell protein using engineered Pichia pastoris (Komagataella phaffii)
  Abstract The economic viability of methanol-based biomanufacturing, particularly with green methanol as feedstock, is often limited by the low value of single-product processes. Here, we developed an integrated co-production strategy in the methylotrophic yeas…
  datacite Jiayu Fang, Shuxian Wang, Guoxia Liu, Yanping Zhang 等 2026 置信度 0.66 BiophysicsBiochemistryMicrobiologyGeneticsMolecular Biology
• Tri-valorization of methanol in a single bioreactor: co-production of enzyme, chemical, and single-cell protein using engineered Pichia pastoris (Komagataella phaffii)
  Abstract The economic viability of methanol-based biomanufacturing, particularly with green methanol as feedstock, is often limited by the low value of single-product processes. Here, we developed an integrated co-production strategy in the methylotrophic yeas…
  datacite Jiayu Fang, Shuxian Wang, Guoxia Liu, Yanping Zhang 等 2026 置信度 0.66 BiophysicsBiochemistryMicrobiologyGeneticsMolecular Biology
• Breaking Data Silos in Biotech: Integration Architectures for Scalable GMP Operations
  Modern biotechnology organizations operate in one of the most complex data environments across contemporary industries. Biopharmaceutical manufacturing, clinical research, quality management, laboratory operations, and regulatory affairs continuously generate …
  datacite Rishi Nareshbhai Lad 2026 置信度 0.66
• Breaking Data Silos in Biotech: Integration Architectures for Scalable GMP Operations
  Modern biotechnology organizations operate in one of the most complex data environments across contemporary industries. Biopharmaceutical manufacturing, clinical research, quality management, laboratory operations, and regulatory affairs continuously generate …
  datacite Rishi Nareshbhai Lad 2026 置信度 0.66
• Enhanced recombinant adeno-associated virus (rAAV) biomanufacturing: Design of experiment (DOE) enabled transfection optimization for maximum full capsid yield and robust scale-up
  Recombinant adeno-associated virus (rAAV) gene therapies are a promising class of therapeutics. While their production via triple transfection in a single cell line offers flexibility regarding modification of the transgene, it faces significant challenges, pa…
  datacite Bogdanovic, Alexandra, Donohue, Nicholas, Glennon, Brian, McDonnell, Susan 等 2026 置信度 0.66 recombinantadeno-associatedvirustherapeuticsempty capsids
• Artificial intelligence and automation in enzyme engineering: evolution, advances, and future perspectives
  Abstract Natural enzymes often fail to meet industrial demands for catalytic efficiency, stability, and substrate specificity, creating a critical bottleneck in biomanufacturing. This review examines how artificial intelligence (AI) and automation are reshapin…
  datacite Kexin Hao, Jianguang Liu, Hui Tang, Yan Zhang 等 2026 置信度 0.66 Biological Sciences not elsewhere classifiedInformation Systems not elsewhere classified
• Artificial intelligence and automation in enzyme engineering: evolution, advances, and future perspectives
  Abstract Natural enzymes often fail to meet industrial demands for catalytic efficiency, stability, and substrate specificity, creating a critical bottleneck in biomanufacturing. This review examines how artificial intelligence (AI) and automation are reshapin…
  datacite Kexin Hao, Jianguang Liu, Hui Tang, Yan Zhang 等 2026 置信度 0.66 Biological Sciences not elsewhere classifiedInformation Systems not elsewhere classified
• Impact of serum/xeno‐free medium and cytokine supplementation on CAR‐T cell therapy manufacturing in stirred tank bioreactors
  Chimeric antigen receptor T‐cell (CAR‐T) therapies have demonstrated clinical efficacy in treating haematological malignancies, resulting in multiple regulatory approvals. However, there is a need for robust manufacturing platforms and the use of GMP‐aligned r…
  datacite Couto, Pedro Silva, Stibbs, Dale J., Springuel, Pierre, Schultz, Ursula 等 2025 置信度 0.66 ATMPCAR-TGMPBiomanufacturingSerum free
• 00 - A Space Bioindustrial Architecture
  The **Space Bioindustrial Architecture (SBA)** is a NASA-grounded settlement-capability assurance and claim-control architecture for determining when biological, hybrid, physicochemical, robotic, digital, power, filtration, and supporting systems may legitimat…
  datacite Kenneth Lee Roberts 2026 置信度 0.66 Structures and MaterialsMedical SciencesMolecular, Cellular, and Tissue EngineeringSystems and Integrative EngineeringOperational Research
• New biotechnological routes to upcycle food by-products and waste into high-value lipids through microalgae
  The increasing demand for sustainable sources of long chain polyunsaturated fatty acids (PUFAs), such as DHA and EPA, has driven research into alternative production methods. This review explores the potential of using FBW and by-products as substrates for mic…
  datacite Giovanni L. Russo, Antonio L. Langellotti 2026 置信度 0.66 BiochemistryBiotechnologyEcologyScience Policy
• New biotechnological routes to upcycle food by-products and waste into high-value lipids through microalgae
  The increasing demand for sustainable sources of long chain polyunsaturated fatty acids (PUFAs), such as DHA and EPA, has driven research into alternative production methods. This review explores the potential of using FBW and by-products as substrates for mic…
  datacite Giovanni L. Russo, Antonio L. Langellotti 2026 置信度 0.66 BiochemistryBiotechnologyEcologyScience Policy
• Serum-free media development and validation for cultivation of C2C12 immortalised murine myosatellite cell line for cultivated meat
  Abstract: The development of cost-effective, serum-free media is critical for scalable cultivated meat production. This study used Design of Experiments (DoE) and high-throughput screening to develop "MMM1", an animal-free, serum-free medium for the C2C12 muri…
  datacite Gordon-Petrovskii, William 2026 置信度 0.66 Cell BiologyCultivated Meat
• Critical assessment of synthetic microbial community strategies in vinegar brewing: from design paradigms to industrialization bottlenecks
  Vinegar brewing traditionally relies on complex, spontaneously assembled microbiota, which often results in batch-to-batch inconsistency and uncontrollable flavor profiles due to environmental fluctuations. Synthetic microbial communities (SynComs) represent a…
  datacite Shiyuan Lin, Yongjian Yu, Yuanyuan Zhu, Ke Wang 等 2026 置信度 0.66 Space ScienceMicrobiologyMolecular BiologyBiotechnologyEnvironmental Sciences not elsewhere classified
• Critical assessment of synthetic microbial community strategies in vinegar brewing: from design paradigms to industrialization bottlenecks
  Vinegar brewing traditionally relies on complex, spontaneously assembled microbiota, which often results in batch-to-batch inconsistency and uncontrollable flavor profiles due to environmental fluctuations. Synthetic microbial communities (SynComs) represent a…
  datacite Shiyuan Lin, Yongjian Yu, Yuanyuan Zhu, Ke Wang 等 2026 置信度 0.66 Space ScienceMicrobiologyMolecular BiologyBiotechnologyEnvironmental Sciences not elsewhere classified
• GlycoMAC: A Multiscale Metabolic-Glycosylation Framework for Predicting Glycosylation Across Conditions in Mammalian Cell Cultures
  Antibody productivity and glycosylation quality in CHO cultures arise from a dynamically evolving metabolic environment, yet models often work in isolation or at a single scale. Here, we present a multiscale mechanistic framework linking molecular, cellular, a…
  datacite Zeng, Yuming, Harcum, Sarah W., Pei, Jinxiang, Xie, Wei 2026 置信度 0.66 Cell Behavior (q-bio.CB)FOS: Biological sciences
• High performance anion exchange chromatography purification of probiotic bacterial extracellular vesicles enhances purity and anti_inflammatory efficacy
  Abstract Bacterial extracellular vesicles (BEVs), including outer membrane vesicles, have emerged as a promising new class of vaccines and therapeutics to treat cancer and inflammatory diseases, among other applications. However, clinical translation of BEVs i…
  datacite Pirolli, Nicholas H., Reus, Laura Samantha C., Mamczarz, Zuzanna, Khan, Sulayman 等 2023 置信度 0.66 bacterial therapeuticsouter membrane vesiclesprobioticspurification
• INTEGRATION OF AUTOMATED GELMA BIOINK FORMULATION TO ENHANCE EXTRUSION BASED BIOPRINTING
  Extrusion based bioprinting is transforming biomanufacturing by enabling highlycontrollable and reproducible fabrication of tissue constructs. This bioprinting modality offers advantages in customization, cytocompatibility, and tunable mechanical properties. D…
  datacite Nho, Laena Olivia 2026 置信度 0.66 BioengineeringAutomat*BioinkBioprint*Tissue Engineering
• Engineering Redox-based Intercellular Communication Channels Towards the Control of Microbial Consortial Behavior
  Microbial communities exist in many facets of life, such as in the human body, including the microbiomes of the gut, mouth, respiratory tract, as well as that in the environment, including microbiomes of the soil, permafrost, and the ocean. While vastly differ…
  datacite Chu, Monica 2026 置信度 0.66 BioengineeringBioelectronicsElectrogeneticsIntercellular signalingMicrobial consortia
• Digital Assembly of Spherical Bio-Ink Particles
  Biological tissues are not a random assembly of cells but a hierarchical and tightly controlled three-dimensional (3D) organization of various cell types. Yet most 3D cell culture systems start with clusters or a random assembly of cells by assuming that the o…
  datacite Zhu, Jinchang 2026 置信度 0.66
• Pre-structuring Product Development Challenges in the Context of Advanced Biomanufacturing
  With an increasing emphasis on research and design at the intersection of biological and cyber-physical systems, collaboration among disciplines is intensifying. Yet, there remains a lack of the integrated use of knowledge, methods, and approaches. This prelim…
  datacite Sonnenberg, Manuel, Miehe, Robert, Kiemel, Steffen, Bauernhansl, Thomas 等 2025 置信度 0.66 advanced biomanufacturingchallengesproduct development
• Social Sciences and Humanities (SSH) Consortium: Essential Societal Infrastructure to Support Canada’s Immuno-Engineering and Biomanufacturing Pipeline
  Project 500122 funded ($633860) by the Canada Foundation for Innovation (CBRF – BRIF Stage 2) / Projet 500122 financé (633860 $) par la Fondation canadienne pour l'innovation (Étape 2 du FRBC – FIRSB)
  datacite Canada Foundation for Innovation | Fondation canadienne pour l'innovation 2023 置信度 0.66
• The Canadian Biomanufacturing Cooperative
  Project 500180 funded ($78852959) by the Canada Foundation for Innovation (CBRF – BRIF Stage 2) / Projet 500180 financé (78852959 $) par la Fondation canadienne pour l'innovation (Étape 2 du FRBC – FIRSB)
  datacite Canada Foundation for Innovation | Fondation canadienne pour l'innovation 2023 置信度 0.66
• Canada's Immuno-Engineering and Biomanufacturing Hub Advanced Therapeutics Manufacturing Facility (CIEBH-ATMF)
  Project 500173 funded ($41763970) by the Canada Foundation for Innovation (CBRF – BRIF Stage 2) / Projet 500173 financé (41763970 $) par la Fondation canadienne pour l'innovation (Étape 2 du FRBC – FIRSB)
  datacite Canada Foundation for Innovation | Fondation canadienne pour l'innovation 2023 置信度 0.66
• Scalable Biomanufacturing for a Net-Zero Economy
  Project 44441 funded ($84721) by the Canada Foundation for Innovation (John R. Evans Leaders Fund) / Projet 44441 financé (84721 $) par la Fondation canadienne pour l'innovation (Fonds des leaders John-R.-Evans)
  datacite Canada Foundation for Innovation | Fondation canadienne pour l'innovation 2023 置信度 0.66
• Accelerating Biomanufacturing Innovation Through Enhanced Capacity forScale-up and Downstream Bioprocess Engineering
  Project 43976 funded ($400000) by the Canada Foundation for Innovation (John R. Evans Leaders Fund) / Projet 43976 financé (400000 $) par la Fondation canadienne pour l'innovation (Fonds des leaders John-R.-Evans)
  datacite Canada Foundation for Innovation | Fondation canadienne pour l'innovation 2022 置信度 0.66
• Sustainable BioManufacturing
  Project 43390 funded ($2000150) by the Canada Foundation for Innovation (Innovation Fund 2023) / Projet 43390 financé (2000150 $) par la Fondation canadienne pour l'innovation (Fonds d'innovation 2023)
  datacite Canada Foundation for Innovation | Fondation canadienne pour l'innovation 2022 置信度 0.66
• Infrastructure to support the development of novel viral sensitizers for innovative biomanufacturing of viral medicines.
  Project 43130 funded ($188998) by the Canada Foundation for Innovation (John R. Evans Leaders Fund) / Projet 43130 financé (188998 $) par la Fondation canadienne pour l'innovation (Fonds des leaders John-R.-Evans)
  datacite Canada Foundation for Innovation | Fondation canadienne pour l'innovation 2022 置信度 0.66
• Advancing the next generation of biomanufacturing systems
  Project 41622 funded ($472000) by the Canada Foundation for Innovation (John R. Evans Leaders Fund) / Projet 41622 financé (472000 $) par la Fondation canadienne pour l'innovation (Fonds des leaders John-R.-Evans)
  datacite Canada Foundation for Innovation | Fondation canadienne pour l'innovation 2020 置信度 0.66
• Microalgae Biomanufacturing Laboratory
  Project 38199 funded ($80000) by the Canada Foundation for Innovation (John R. Evans Leaders Fund) / Projet 38199 financé (80000 $) par la Fondation canadienne pour l'innovation (Fonds des leaders John-R.-Evans)
  datacite Canada Foundation for Innovation | Fondation canadienne pour l'innovation 2018 置信度 0.66
• Advanced methods for synthesis, biosynthesis, and biomanufacturing
  Project 30737 funded ($948774) by the Canada Foundation for Innovation (Leading Edge Fund 2012) / Projet 30737 financé (948774 $) par la Fondation canadienne pour l'innovation (Fonds de l'avant-garde 2012)
  datacite Canada Foundation for Innovation | Fondation canadienne pour l'innovation 2011 置信度 0.66
• Elucidation of the growth phenotypes of 82 strains from the <i>Halomonas</i> genus
  Microbial growth phenotype is commonly summarised by a small set of parameters: specific growth rate, lag phase duration, maximum cell density, and growth curve profile; yet even within a single genus these characteristics can vary substantially across species…
  datacite Alexander Baumbach 2026 置信度 0.66 Bioprocessing, bioproduction and bioproductsIndustrial microbiology (incl. biofeedstocks)
• Elucidation of the growth phenotypes of 82 strains from the <i>Halomonas</i> genus
  Microbial growth phenotype is commonly summarised by a small set of parameters: specific growth rate, lag phase duration, maximum cell density, and growth curve profile; yet even within a single genus these characteristics can vary substantially across species…
  datacite Alexander Baumbach 2026 置信度 0.66 Bioprocessing, bioproduction and bioproductsIndustrial microbiology (incl. biofeedstocks)
• Intracellular Measurement-Informed Multiscale Modeling for Scalable iPSC Manufacturing
  Scalable manufacturing of human induced pluripotent stem cells (iPSCs) is essential for industrial-scale production of cell therapies and regenerative medicines. However, the 3D aggregate cultures used in manufacturing exhibit substantial spatial and metabolic…
  datacite Cheng, Fuqiang, Jahromi, Zahra Foroozan, Wang, Keqi, Caldwell, Thomas C. 等 2026 置信度 0.66 Cell Behavior (q-bio.CB)FOS: Biological sciencesFOS: Biological sciences
• Single-Cell Isolation and Ejection from Microfluidic Cell Traps for High-Resolution Bioprinting
  Motivation: Precise single-cell dispensing is critical for advancements in biomedical technology, personalized medicine, and biotechnology. “On-demand” precision-placement of individual cells is expected to enable the cell-by-cell assembly of functional micros…
  datacite Kögler, Klaus Ulrich 2026 置信度 0.66 MicrofluidicsBioprintingTissue EngineeringDispensingMEMS
• Building a Systems-Level Understanding of Vibrio natriegens for Bioengineering
  Nature has an impressive track record of finding creative solutions to problems. These remarkable strategies have presented scientists with many of the best tools for biotechnology, from molecules that target debilitating diseases to extraordinary materials th…
  datacite Lima, Matthew 2026 置信度 0.66 BioengineeringMetabolic EngineeringMulti-omicsSystems Biology
• Genetic Tool Development and Pathway Elucidation in Non-model Bacteria for Biological Upcycling of Plastic Waste
  Plastics have become ubiquitous in modern life due to their low cost, lightweight nature, tunable properties, and durability. However, the accessibility of plastics during their functional lifetimes can also become a drawback at the end of life, owing to their…
  datacite Tian, Yuxin 2026 置信度 0.66 Chemical EngineeringFOS: Chemical engineeringEngineering
• Microbial Resource Engineering for Sustainable Biomanufacturing
  Nutrients are essential elements for the sustenance of microorganisms. Microbes and their surrounding environment have an intricate relationship, and it hinges significantly on nutrient availability. The responses of microorganisms to nutrients are highly dive…
  datacite Lee, Hakyung 2026 置信度 0.66 Civil and Environmental EngineeringEngineeringEnvironmental EngineeringFOS: Environmental engineering
• Optimization and Mechanistic Understanding for Value-added Products Production through Anaerobic Digestion
  Anaerobic digestion (AD) is extensively adopted in wastewater treatment plants (WWTPs), aids in solid dissolution, sludge volume reduction, and bioenergy recovery through biogas production. However, less than 30 % of organic carbon from AD feedstock is convert…
  datacite Sun, Jiasi 2026 置信度 0.66 EngineeringAnaerobic digestionArresting methanogenesisMachine learningMicrobial communities
• 3D Bioprinting for Vascularization
  In the world of clinic treatments, 3D-printed tissue constructs have emerged as a less invasive treatment method for various ailments. Printing processes, scaffold and scaffold free materials, cells used, and imaging for analysis are all factors that must be o…
  datacite Mir, Amatullah, Lee, Eugenia, Shih, Wesley, Koljaka, Sarah 等 2023 置信度 0.66 bioprintingtissue engineeringvasculature3D modelingscaffolds
• 3D Bioprinting for Vascularization
  In the world of clinic treatments, 3D-printed tissue constructs have emerged as a less invasive treatment method for various ailments. Printing processes, scaffold and scaffold free materials, cells used, and imaging for analysis are all factors that must be o…
  datacite Mir, Amatullah, Lee, Eugenia, Shih, Wesley, Koljaka, Sarah 等 2023 置信度 0.66 bioprintingtissue engineeringvasculature3D modelingscaffolds
• Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family
  2-Hydroxyacyl-CoA lyase/synthase (HACL/S) is a thiamine diphosphate (ThDP)-dependent versatile enzyme originally discovered in the mammalian α-oxidation pathway. HACL/S natively cleaves 2-hydroxyacyl-CoAs and, in its reverse direction, condenses formyl-CoA wit…
  datacite Kim, Youngchang, Lee, Seung Hwan, Gade, Priyanka, Nattermann, Maren 等 2024 置信度 0.66
• Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family
  2-Hydroxyacyl-CoA lyase/synthase (HACL/S) is a thiamine diphosphate (ThDP)-dependent versatile enzyme originally discovered in the mammalian α-oxidation pathway. HACL/S natively cleaves 2-hydroxyacyl-CoAs and, in its reverse direction, condenses formyl-CoA wit…
  datacite Kim, Youngchang, Lee, Seung Hwan, Gade, Priyanka, Nattermann, Maren 等 2024 置信度 0.66
• Research progress on the mechanisms of bidirectional fermentation-driven structural diversification of natural products
  Natural medicines play a significant role in disease prevention and treatment due to their diverse biological activities. However, their complex chemical composition, low concentrations of active compounds, and toxicity limit their clinical application. Tradit…
  datacite Wang, Zixuan, Zhu, Ting, Liu, Bing, Liu, Yuchen 等 2026 置信度 0.66 BiochemistryPharmacologyBiotechnologyEcologyFOS: Biological sciences
• Research progress on the mechanisms of bidirectional fermentation-driven structural diversification of natural products
  Natural medicines play a significant role in disease prevention and treatment due to their diverse biological activities. However, their complex chemical composition, low concentrations of active compounds, and toxicity limit their clinical application. Tradit…
  datacite Wang, Zixuan, Zhu, Ting, Liu, Bing, Liu, Yuchen 等 2026 置信度 0.66 BiochemistryPharmacologyBiotechnologyEcologyFOS: Biological sciences
• Dual Use in AI-Driven Biotechnology: How Should We Govern It?
  This technical commentary discusses the dual-use implications of artificial intelligence in biotechnology, with particular attention to bioinformatics, smart biomanufacturing, and AI-enabled research infrastructure. The article examines how AI systems can acce…
  datacite Anteghini, Marco 2026 置信度 0.66
• Dual Use in AI-Driven Biotechnology: How Should We Govern It?
  This technical commentary discusses the dual-use implications of artificial intelligence in biotechnology, with particular attention to bioinformatics, smart biomanufacturing, and AI-enabled research infrastructure. The article examines how AI systems can acce…
  datacite Anteghini, Marco 2026 置信度 0.66
• Organic wastes to next-generation bioplastics through intelligent biomanufacturing of polyhydroxyalkanoates
  Organic waste generation continues to pose major environmental challenges, including greenhouse gas emissions, soil and water contamination, and resource depletion. Here, we highlight how intelligent biomanufacturing integrating engineered microbes, waste-deri…
  datacite Esmaeili, Yasaman, Timms, Wendy, Barrow, Colin J, Naebe, Minoo 等 2026 置信度 0.66 Environmental managementBiological sciencesFOS: Biological sciencesEnvironmental sciences
• Strategic Role of Botanical Sciences in Viksit Bharat – 2047: A Review
  As India targets a $30 trillion developed economy by 2047, the classical study of plants has transitioned into a high-stakes driver of national sovereignty. This article synthesizes current research and policy frameworks primarily the BioE3 Policy and National…
  datacite Ghalme R. L., Ahire Y. R. 2026 置信度 0.66
• Strategic Role of Botanical Sciences in Viksit Bharat – 2047: A Review
  As India targets a $30 trillion developed economy by 2047, the classical study of plants has transitioned into a high-stakes driver of national sovereignty. This article synthesizes current research and policy frameworks primarily the BioE3 Policy and National…
  datacite Ghalme R. L., Ahire Y. R. 2026 置信度 0.66
• The Application of Nuclear Magnetic Resonance Towards Understanding Chromatographic Separations of Proteins
  Protein chromatography remains indispensable for biomanufacturing, with multiple, orthogonal chromatographic techniques typically employed for the downstream processing of a single protein of interest. However, the mechanisms underpinning chromatographic separ…
  datacite Chambers, Tamsin 2022 置信度 0.66 Protein chromatographyNMRIn-column interactionsMass transfer
• 3D biocement printing: scaling up living mineral structures
  Biocementation via microbially induced calcium carbonate precipitation (MICP) provides a biologically mediated approach for producing inorganic materials, with reduced embodied energy, using bacterial metabolism to trigger mineral formation under ambient condi…
  datacite Antorveza Paez, Karen Andrea, Kindler, Robert O., Terzis, Dimitrios, Dutto, Alessandro 等 2026 置信度 0.66 3D printingBiocementationLiving Materials3D Biocement Printingextrusion-based biomanufacturing
• Scalable Biofabrication Strategies for Engineering Microvascularized, Anisotropic Cardiac Tissues
  Heart failure is the leading cause of mortality globally, and the limited regenerative capacity of the adult myocardium following injury, such as from myocardial infarction, motivates the need for engineered cardiac tissue replacements. The native myocardium i…
  datacite Jewett, Maggie 2026 置信度 0.66 cardiac tissue engineeringanisotropic heart tissuecardiac tissue repairinduced pluripotent stem cellshydrogel composites
• Advanced bioprocess design and molecular insights into Bacillus fermentation to promote sustainable lipopeptide production
  Interdisciplinary research is a prerequisite for addressing modern society's greatest challenge – environmental protection. The biotechnological production of chemicals and pharmaceuticals, also known as ‘biomanufacturing’, may represent a measure to counterac…
  datacite Treinen, Chantal 2025 置信度 0.66 BiomanufacturingBioeconomyBioprocess engineeringBiosurfactantBacillus
• Development and demonstration of a Modular Astrobiological Experiments (MAEx) payload for autonomous biological monitoring in Low Earth Orbit (LEO)
  The spaceflight environment presents unique physicochemical conditions, including microgravity, ionizing radiation, altered fluid transport, and confined engineered habitats, which influence biological systems and biomolecular assembly processes. These conditi…
  datacite Jangir, Yamini, Ghosh, Samrat, Nayaka, Vinay, Ali, Mubashir 等 2026 置信度 0.66 Instrumentation and Methods for Astrophysics (astro-ph.IM)FOS: Physical sciencesFOS: Physical sciences
• Production of extracellular vesicles from beta cells in stirred tanks enhances maturation and ectosome release with preserved immune properties - dataset
  The dataset concerns experimental data generated to evaluate the scalable production of beta cell-derived small extracellular vesicles (sEV) in stirred tank bioreactors (STR), and the impact of culture conditions on cell physiology, sEV yield, purity, morpholo…
  datacite De Beaurepaire, Laurence, Salama, Apolline, Bosch, Steffi, Mosser, Mathilde 2026 置信度 0.66
• 3rd International Conference on Life Sciences (LiSci 2026)
  3rd International Conference on Life Sciences (LiSci 2026)July 28 ~ 29, 2026, Virtual Conferencehttps://lisci2026.org/Scope3rd International Conference on Life Sciences (LiSci 2026) brings together a global community of researchers, innovators, educators, and …
  datacite NA 2026 置信度 0.66
• 3rd International Conference on Life Sciences (LiSci 2026)
  3rd International Conference on Life Sciences (LiSci 2026)July 28 ~ 29, 2026, Virtual Conferencehttps://lisci2026.org/Scope3rd International Conference on Life Sciences (LiSci 2026) brings together a global community of researchers, innovators, educators, and …
  datacite NA 2026 置信度 0.66
• A Hybrid Deep Learning Framework For Real-Time Yield Prediction And Process Monitoring In Biomanufacturing
  Bioprocessing plays an essential role in the large-scale production of biological products, where accurate monitoring and control are key for both yield and quality. This work aims to develop and assess a predictive framework based on Artificial Neural Network…
  datacite Hadiza Ibrahim Aminu, Abdullahi Mohammed Ibrahim, Buhari Aliyu, Zainab Ibrahim Aminu 等 2026 置信度 0.66
• A Hybrid Deep Learning Framework For Real-Time Yield Prediction And Process Monitoring In Biomanufacturing
  Bioprocessing plays an essential role in the large-scale production of biological products, where accurate monitoring and control are key for both yield and quality. This work aims to develop and assess a predictive framework based on Artificial Neural Network…
  datacite Hadiza Ibrahim Aminu, Abdullahi Mohammed Ibrahim, Buhari Aliyu, Zainab Ibrahim Aminu 等 2026 置信度 0.66
• Data from: An orthogonal workflow of electrochemical, computational, and thermodynamic methods reveals limitations of using a literature-reported insulin binding peptide in biosensors
  Developing a continuous insulin-monitoring biosensor is of great importance for both the cellular biomanufacturing industry and for treating diabetes mellitus. Such a sensor needs to be able to effectively monitor insulin across a range of temperatures and pHs…
  datacite Austin, Katherine, Torres, Jazmine, Waters, Jeffery, Balog, Eva Rose 等 2026 置信度 0.66 FOS: Chemical engineeringFOS: Chemical engineeringInsulinInsulin-binding peptideIsothermal titration calorimetry
• EPA’s Center for Computational Toxicology &amp; Exposure
  Presentation to the Biomanufacturing Research Institute and Technology Enterprise (BRITE) at NC Central University September 2023 Search for CCTE records in EPA’s Science Inventory by typing in the title at this link.https://cfpub.epa.gov/si/si_public_search_r…
  datacite Sams, Reeder 2023 置信度 0.66 Toxicology (incl. clinical toxicology)
• EPA’s Center for Computational Toxicology &amp; Exposure
  Presentation to the Biomanufacturing Research Institute and Technology Enterprise (BRITE) at NC Central University September 2023 Search for CCTE records in EPA’s Science Inventory by typing in the title at this link.https://cfpub.epa.gov/si/si_public_search_r…
  datacite Sams, Reeder 2023 置信度 0.66 Toxicology (incl. clinical toxicology)
• EPA’s Center for Computational Toxicology &amp; Exposure
  Presentation to the Biomanufacturing Research Institute and Technology Enterprise (BRITE) at North Carolina Central University April 2023 Search for CCTE records in EPA’s Science Inventory by typing in the title at this link. https://cfpub.epa.gov/si/si_public…
  datacite Sams, Reeder 2023 置信度 0.66 Toxicology (incl. clinical toxicology)
• EPA’s Center for Computational Toxicology &amp; Exposure
  Presentation to the Biomanufacturing Research Institute and Technology Enterprise (BRITE) at North Carolina Central University April 2023 Search for CCTE records in EPA’s Science Inventory by typing in the title at this link. https://cfpub.epa.gov/si/si_public…
  datacite Sams, Reeder 2023 置信度 0.66 Toxicology (incl. clinical toxicology)
• Impedance Spectroscopy: Recent Developments As a PAT for Pharmaceutical Freeze-Drying. Bio manufacturing Congress, London, July 8-9 2020
  cite as: Smith, G. (2020) Impedance Spectroscopy: Recent Developments As a PAT for Pharmaceutical Freeze-Drying. Online presentation at Bio manufacturing Congress, London, 2020 July 8-9. Inaugural Biomanufacturing Congress FORMULATION &amp; DELIVERY SERIES UK
  datacite Smith, Geoffrey 2021 置信度 0.66 Pharmaceutical sciences
• Impedance Spectroscopy: Recent Developments As a PAT for Pharmaceutical Freeze-Drying. Bio manufacturing Congress, London, July 8-9 2020
  cite as: Smith, G. (2020) Impedance Spectroscopy: Recent Developments As a PAT for Pharmaceutical Freeze-Drying. Online presentation at Bio manufacturing Congress, London, 2020 July 8-9. Inaugural Biomanufacturing Congress FORMULATION &amp; DELIVERY SERIES UK
  datacite Smith, Geoffrey 2021 置信度 0.66 Pharmaceutical sciences
• Methanol-based biosynthesis of p-coumaric acid by engineered Pichia pastoris
  Abstract p-Coumaric acid (p-CA) is a key aromatic precursor for the biosynthesis of flavonoids, stilbenoids, and other high-value phenylpropanoids. While microbial production of p-CA typically relies on sugar-based substrates, methanol offers a sustainable and…
  datacite Chen, Mengyuan, Fang, Jiayu, Wang, Shuxian, Liu, Guoxia 等 2026 置信度 0.66 BiochemistrySpace ScienceGeneticsFOS: Biological sciencesMolecular Biology