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Objective: To develop a point cloud non-rigid deformation algorithm, local projection deformation match (LPD-Match), for optimizing the edge transition of the nasal prosthesis complementing the generative artificial intelligence-based facial mesh generation ne…
pubmed
Guo SW, Qin QZ, Li YL, Wu HY 等
2026 Jul 9
置信度 0.82
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Complete denture restoration, as a major treatment for reconstructing masticatory function and restoring facial esthetics in patients with edentulism, has long been constrained by challenges inherent in traditional workflows, including reliance on experience, …
pubmed
Zhou YS
2026
置信度 0.82
-
Vinegar brewing traditionally relies on complex, spontaneously assembled microbiota, which often results in batch-to-batch inconsistency and uncontrollable flavor profiles due to environmental fluctuations. Synthetic microbial communities (SynComs) represent a…
pubmed
Lin S, Yu Y, Zhu Y, Wang K 等
2026
置信度 0.82
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The sterile insect technique (SIT) represents an environmentally benign pest management strategy. Spodoptera litura (Fabricius) (Lepidoptera: Noctuidae), a highly polyphagous pest, poses a significant threat to global agricultural productivity. To enable effec…
pubmed
Qin H, Meng C, Jiang S, Wang H 等
2026 Aug 1
置信度 0.82
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Complex tissue/organ regeneration is a well-orchestrated biological process that is orchestrated by the coordinated effort of neural, vascular and immune systems, accompanied by multiple cellular interactions and signal crosstalk. The beneficial pro-regenerati…
pubmed
Zhao Z, Wu C
2026
置信度 0.82
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Cardiovascular aging represents the initial stage of systemic bodily aging. Endothelial cell (EC) senescence serves a key role in vascular aging. However, therapeutic strategies targeting ECs senescence remain insufficiently explored. The present study aimed t…
pubmed
Jin H, Bai H, Liu T, Wang H 等
2026 Aug
置信度 0.82
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Myrcene is a high-value monoterpene extensively applied in the fragrance, flavor, and agricultural industries, yet its efficient microbial production remains challenging due to pathway competition and limited metabolic flux. Compartmentalization offers a uniqu…
pubmed
Wang Z, Wang J, Liu Y, Chen M 等
2027 Jan
置信度 0.82
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Cadmium (Cd) contamination in acidic soils poses a critical threat to agricultural productivity and safety. However, effective microbial strategies remain challenging due to the scarcity of microbial resources that are dual-resistant to acid and Cd. Here, we i…
pubmed
Yue Z, Liu Y, Miao J, Wang N 等
2026 Oct
置信度 0.82
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A novel slow-growing bacterium, designated strain ag2_l2_5A T , was isolated from pine forest soil at Kagamiyama, Hiroshima, Japan, by using a gel microdroplet cultivation approach. The strain was characterized as a Gram-negative, non-motile bacterium with a s…
pubmed
Suzuki R, Shimomura Y, Iwashita T, Meng XY 等
2026 Jul
置信度 0.82
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The scalable production of recombinant adeno-associated viruses (rAAVs) remains a critical challenge in gene therapy manufacturing. While HEK293 and insect cell systems dominate current production platforms, each presents significant limitations in cost, scala…
pubmed
Tzimou K, López-García G, Sipahi MI, Nielsen LK 等
2026 Sep 10
置信度 0.82
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Hydrogenophilus thermoluteolus strain TH-1 is a thermophilic hydrogen-oxidizing bacterium that can autotrophically grow using H 2 , CO 2, and O 2 with the highest rate among autotrophs. However, despite its significant potential for use in biomanufacturing fro…
pubmed
Kurita T, Ohmura N, Hirano SI, Glass TR
2026 Jul 1
置信度 0.82
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Antimicrobial peptides (AMPs) are promising alternatives to conventional antibiotics against bacterial infections. However, the discovery of AMPs is impeded by the limitations of biochemical screening and the difficulty computational approaches face in balanci…
pubmed
Liu J, Chen Y, Tang J, Xing X 等
2026 May 4
置信度 0.82
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The sexual life cycle represents a natural engine for promoting genetic diversity in yeast. However, harnessing it for controllable, rapid evolution in industrial yeast strains remains a big challenge. Here, we developed quantitative mating and sporulation met…
pubmed
Song L, Wu Y, Hua L, Liu Q 等
2026 Sep
置信度 0.82
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This study focused on enhancing the catalytic efficiency of 3α-hydroxysteroid dehydrogenase (3α-HSD) from Comamonas testosteroni toward androsterone. By employing enzyme engineering strategy combining semi-rational design with the protein language …
pubmed
Wang J, Han Z, Wang Q, Luo W
2026 Jun 30
置信度 0.82
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Neophytadiene is an important volatile organic compound found in tobacco; however, its biosynthesis pathway remains unclear. In this study, linalool dehydratase-isomerase (LinD) was first mined and rationally designed for converting phytol to neophytadiene, re…
pubmed
Wang F, Han X, Irani M, Zhang X 等
2026 Jul 17
置信度 0.82
-
Chemical investigation of the soil-derived actinomycete Streptomyces sp. CPU-W6 led to the discovery of three novel aminated benzoic dimers, cpumycins A-C ( 1 - 3 ). Their structures, featuring a distinctive C - N - C -linked heterodimeric skeleton, were deter…
pubmed
Wang Z, Du Y, Zhang D, Yang Y 等
2026 Jul 24
置信度 0.82
-
Methanol oxidation by alcohol oxidases (AOXs) is a key bottleneck in one-carbon (C1) bioconversion due to limited catalytic efficiency and poor formaldehyde tolerance. Here, we report the directed evolution of an alcohol oxidase from Gloeophyllum trabeum , yie…
pubmed
Ding XW, Sun YJ, Hu XY, Yang JY 等
2027 Jan
置信度 0.82
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Controlling biocatalytic activity in melt-processed polymers is a central challenge for triggered depolymerization, because enzymes deactivate at melt-extrusion temperatures. Here, metal-organic framework-gated biocatalysis, achieved by encapsulating enzymes w…
pubmed
Cui S, Tian J, Zhu M, Liu Z 等
2026 Jun 30
置信度 0.82
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Fatty acid esters are building blocks in next-generation biofuels, eco-friendly detergents, crop-enhancing adjuvants, and high-value cosmetic emollients. However, their industrial production relies on two unsustainable approaches: petrochemical-derived chemica…
pubmed
Wang J, Zhang Y, Tong B, Meng Q 等
2026
置信度 0.82
-
Echinocandin B (ECB), a fungal non-ribosomal lipopeptide, serves as the exclusive natural precursor of the front-line antifungal anidulafungin. Despite its clinical importance, ECB production remains suboptimal due to incomplete understanding of its biosynthes…
pubmed
Yang X, Gao J, Shen D, Zhang Y 等
2026
置信度 0.82
-
Aspartate-α-decarboxylase (ADC) catalyzes the decarboxylation of L-aspartate to produce β-alanine, while was restricted for applications by its mechanism-based inactivation. Here the flexibility of the β-sheet containing Y58, a critical resid…
pubmed
Zhou J, Wang F, Zhao Y, Lin Y 等
2026
置信度 0.82
-
Neutrophils are an ideal drug carrier because of their specific targeting and effective accumulation at sites of inflammation. However, the clinical application of neutrophils as drug carriers is constrained by the inability to sustain ex vivo culture and thei…
pubmed
Li X, Chen Y, Xing X, Wen C 等
2026 Jun 29
置信度 0.82
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Anthranilic acid (ANTA) and its derivatives, such as N-methylanthranilic acid (NMAA) and 3-hydroxyanthranilic acid (3-HAA), are valuable aromatic chemicals with wide applications in the pharmaceutical and chemical industries due to their antibacterial, anti-in…
pubmed
Zhang W, Zhang X, Lu L, Gao Y 等
2026
置信度 0.82
-
Additive manufacturing offers an effective approach for fabricating biodegradable porous scaffolds that can adapt to the mechanical properties of jawbones. Zinc (Zn) and its alloys are considered promising degradable materials due to their appropriate degradat…
pubmed
Lin Z, Zhu S, Wu Y, Han Y 等
2026 Aug
置信度 0.82
-
The potential of peony seed meal protein (PSMP) as a source of bioactive peptides has not been fully explored. Three novel peptides (PADAPF, FDQGNF, AVFPSIVGRPR) with antioxidant and hypoglycemic activities were screened from the gastrointestinal digest (GID) …
pubmed
Xu C, Wang Y, Guo G, Yue Y 等
2026 Jun 26
置信度 0.82
-
CD73 is a key enzyme in the adenosine-mediated immunosuppressive pathway and represents an attractive target for cancer immunotherapy. Here, we aimed to develop novel anti-CD73 antibodies with dual mechanisms of action by simultaneously inhibiting enzymatic ac…
pubmed
Zhang M, Yuan H, Pan X, Li X 等
2026
置信度 0.82
-
Freeform 3D ice printing is emerging as a promising additive manufacturing method with potential applications in engineering, medicine, science, and art. Printing ice at the micrometer-millimeter scale is a challenging, high-frequency additive manufacturing pr…
pubmed
Garcia A, Garg A, Yang F, Ozdoganlar OB 等
2026 Jun 22
置信度 0.82
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