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• Single-use technologies for the production of cell therapeutics : Whitepaper
  The field of biomanufacturing has ained considerable attention in recent years, prompting greater investment in research and development to address the growing need for innovative, accessible, and affordable treatment options. While recombinant protein therape…
  datacite Teale, Misha A., Jossen, Valentin, Steinfatt, Tim, Bayer, Marcus 等 2026 置信度 0.66 000 | Informatik, Information und Wissen, allgemeine Werke
• Host-Aware Control of Gene Expression using Data-Enabled Predictive Control
  Cybergenetic gene expression control in bacteria enables applications in engineering biology, drug development, and biomanufacturing. AI-based controllers offer new possibilities for real-time, single-cell-level regulation but typically require large datasets …
  datacite Perreault, Liam, Kempf, Idris, Sechkar, Kirill, Lugagne, Jean-Baptiste 等 2026 置信度 0.66 Systems and Control (eess.SY)FOS: Electrical engineering, electronic engineering, information engineeringFOS: Electrical engineering, electronic engineering, information engineeringI.2.8; I.6.492C42
• Lume-LifeBio: A Deterministic Governance Substrate for Biological, Pharmaceutical, and Biomanufacturing Systems
  Biological and pharmaceutical systems operate under extreme safety, regulatory, and precision constraints — involving complex multi-stage processes from genomic analysis to biologics manufacturing, from sterile processing to cold-chain distribution. Yet today,…
  datacite Andrews, Ronald Jason 2026 置信度 0.66
• High T-cell concentration bioprocessing for cell therapy manufacturing
  Chimeric antigen receptor (CAR) T-cell therapies have provided life-saving alternatives when conventional blood cancer treatments were not successful. This therapy is based on genetically modifying T cells to express CAR, to increase their ability to recognize…
  datacite Kunitskaya, Alina 2026 置信度 0.66
• Novel activity assay development for soluble T-cell activators in bioprocessing
  Chimeric antigen receptor (CAR) T-cell therapy has emerged as a highly promising cell-based approach for the treatment of cancers. A key initial step in biomanufacturing is for T-cells to be activated before their transduction so as to promote their transfecti…
  datacite Zhang, Yishuang 2023 置信度 0.66
• Mechanical characterization of 3D in vitro tissues
  Brain organoids are self-assembled, three-dimensionally structured tissues that are typically derived from pluripotent stem cells. They are multicellular aggregates that can more accurately recapitulate the tissue microenvironment compared to other cell cultur…
  datacite Vaez Ghaemi, Roza 2023 置信度 0.66
• Biocatalysis and bioprocess engineering for terpenoid production
  The biomanufacturing of terpenoids is limited by the low yields of heterologously expressed biosynthetic pathway and challenges associated with recovering these products at commercial scales. To enhance the flux through methylerythritol phosphate (MEP) pathway…
  datacite Ayakar, Sonal 2021 置信度 0.66
• The Flow Must Go On: Algorithms for Scheduling in Biomanufacturing
  datacite van den Houten, K.C. 2026 置信度 0.66
• Machine learning for process monitoring and adaptive control in continuous chromatography
  Process efficiency and adaptability are becoming growing priorities in biopharmaceutical manufacturing. In recent years, the industry has moved towards intensified and continuous operations to meet rising demand for monoclonal antibodies and other therapeutic …
  datacite Michalopoulou, Foteini 2025 置信度 0.66
• Towards continuous biomanufacturing a computational approach for the intensification of monoclonal antibody production
  Current industrial trends encourage the development of sustainable, environmentally friendly processes with reduced energy and raw material consumption. Meanwhile, the increasing market demand as well as the tight regulations in product quality, necessitate ef…
  datacite Papathanasiou, Maria 2017 置信度 0.66
• Integrated multi-scale mathematical models for biologics process development
  The therapeutic monoclonal antibody (mAb) market is witnessing an unprecedented growth having nearly duplicated since 2012. Faster regulatory approvals and an increasing number of biosimilars are among the most important mAb market expansion drivers. As the ma…
  datacite Martins de Jesus Lima Grilo, António Carlos 2019 置信度 0.66
• Analysis across scales: Integrated insights in metabolism and economic feasibility of recombinant protein production from CO2 and H2
  Efficient microbial production processes are essential for sustainable biomanufacturing, yet optimizing strain performance and bioreactor conditions remains challenging due to the complex interplay between cellular metabolism and process parameters. Processes …
  datacite Sugiarto, Titania Insani, Blank, Lars M., Alter, Tobias Benedikt 2026 置信度 0.66 GasfermentationCompartment modelMetabolic modelTechno-Economic analysis
• Analysis across scales: Integrated insights in metabolism and economic feasibility of recombinant protein production from CO2 and H2
  Efficient microbial production processes are essential for sustainable biomanufacturing, yet optimizing strain performance and bioreactor conditions remains challenging due to the complex interplay between cellular metabolism and process parameters. Processes …
  datacite Sugiarto, Titania Insani, Blank, Lars M., Alter, Tobias Benedikt 2026 置信度 0.66 GasfermentationCompartment modelMetabolic modelTechno-Economic analysis
• Instrumentation, multi-omics, and computational approaches to elucidate cell state dynamics in human induced pluripotent stem cell expansion biomanufacturing
  Expansion bioprocessing enables the scalable production of human induced pluripotent stem cells (hiPSCs) for therapeutic use, generating populations in the millions to trillions. Despite growing global infrastructure and increasing clinical trial activity, met…
  datacite Colter, James 2025 置信度 0.66 InstrumentationOmicsComputational MethodsHuman Induced Pluripotent Stem CellsBiomanufacturing
• Insect pest management in the age of synthetic biology
  Arthropod crop pests are responsible for 20% of global annual crop losses, a figure predicted to increase in a changing climate where the ranges of numerous species are projected to expand. At the same time, many insect species are beneficial, acting as pollin…
  datacite Mateos Fernández, Rubén, Petek, Marko, Gerasymenko, Iryna, Juteršek, Mojca 等 2021 置信度 0.66 crop protectioninsect pestspheromonesbiotechnologysynthetic biolog
• Ultra-rapid and high-titer biomanufacturing of trehalose 6-phosphate by an in vitro synthetic biology platform
  Abstract Trehalose 6-phosphate (T6P), often referred to as plant insulin, serves as a central signaling molecule that regulates carbon partitioning and sucrose flux in plants, thereby influencing key agronomic traits, such as grain yield and drought resilience…
  datacite Liu, Bohua, Guo, Qingqing, Wang, Shuo, Shi, Ting 等 2026 置信度 0.66 Plant BiologyFOS: Biological sciences
• Additional file 1 of Ultra-rapid and high-titer biomanufacturing of trehalose 6-phosphate by an in vitro synthetic biology platform
  Supplementary Material 1
  datacite Liu, Bohua, Guo, Qingqing, Wang, Shuo, Shi, Ting 等 2026 置信度 0.66 Plant BiologyFOS: Biological sciences
• Additional file 1 of Ultra-rapid and high-titer biomanufacturing of trehalose 6-phosphate by an in vitro synthetic biology platform
  Supplementary Material 1
  datacite Liu, Bohua, Guo, Qingqing, Wang, Shuo, Shi, Ting 等 2026 置信度 0.66 Plant BiologyFOS: Biological sciences
• Ultra-rapid and high-titer biomanufacturing of trehalose 6-phosphate by an in vitro synthetic biology platform
  Abstract Trehalose 6-phosphate (T6P), often referred to as plant insulin, serves as a central signaling molecule that regulates carbon partitioning and sucrose flux in plants, thereby influencing key agronomic traits, such as grain yield and drought resilience…
  datacite Liu, Bohua, Guo, Qingqing, Wang, Shuo, Shi, Ting 等 2026 置信度 0.66 Plant BiologyFOS: Biological sciences
• The HHS Dietary Guidelines Reset: What the most significant U.S. nutrition policy shift in decades means for food manufacturers, ingredient suppliers, and the broader food ecosystem
  This report analyzes the January 2026 update to the U.S. Department of Health and Human Services Dietary Guidelines for Americans, the sharpest departure from prior federal nutrition policy in more than three decades. The guidance discourages ultra-processed f…
  datacite Gupta, Ravi 2026 置信度 0.66 HHS dietary guidelinesfood policyultra-processed foodsfood reformulationFDA front-of-package labeling
• The HHS Dietary Guidelines Reset: What the most significant U.S. nutrition policy shift in decades means for food manufacturers, ingredient suppliers, and the broader food ecosystem
  This report analyzes the January 2026 update to the U.S. Department of Health and Human Services Dietary Guidelines for Americans, the sharpest departure from prior federal nutrition policy in more than three decades. The guidance discourages ultra-processed f…
  datacite Gupta, Ravi 2026 置信度 0.66 HHS dietary guidelinesfood policyultra-processed foodsfood reformulationFDA front-of-package labeling
• The Method for Human Immortality:An Engineering Blueprint for Maintaining the Prefrontal Cortex
  Abstract This paper presents an engineering blueprint for human consciousness immortality, grounded in the theoretical framework of On the Origin of Consciousness. Consciousness is anchored in the circuit architecture of the prefrontal cortex, not in the neuro…
  datacite 何, 其 2026 置信度 0.66
• The Method for Human Immortality:An Engineering Blueprint for Maintaining the Prefrontal Cortex
  Abstract This paper presents an engineering blueprint for human consciousness immortality, grounded in the theoretical framework of On the Origin of Consciousness. Consciousness is anchored in the circuit architecture of the prefrontal cortex, not in the neuro…
  datacite 何, 其 2026 置信度 0.66
• Lume-LifeBio: A Deterministic Governance Substrate for Biological, Pharmaceutical, and Biomanufacturing Systems
  Biological and pharmaceutical systems operate under extreme safety, regulatory, and precision constraints — involving complex multi-stage processes from genomic analysis to biologics manufacturing, from sterile processing to cold-chain distribution. Yet today,…
  datacite Andrews, Ronald Jason 2026 置信度 0.66 DAIGSdeterministic governancebiotechnologypharmaceutical manufacturingbiologics
• Lume‑LifeBio: A Deterministic Governance Substrate for Biological, Pharmaceutical, and Biomanufacturing Systems
  Biological and pharmaceutical systems operate under extreme safety, regulatory, and precision constraints — involving complex multi‑stage processes from genomic analysis to biologics manufacturing, from sterile processing to cold‑chain distribution. Yet today,…
  datacite Andrews, Ronald Jason 2026 置信度 0.66 DAIGSdeterministic governancebiotechnologypharmaceutical manufacturingbiologics
• Lume‑LifeBio: A Deterministic Governance Substrate for Biological, Pharmaceutical, and Biomanufacturing Systems
  Biological and pharmaceutical systems operate under extreme safety, regulatory, and precision constraints — involving complex multi‑stage processes from genomic analysis to biologics manufacturing, from sterile processing to cold‑chain distribution. Yet today,…
  datacite Andrews, Ronald Jason 2026 置信度 0.66 DAIGSdeterministic governancebiotechnologypharmaceutical manufacturingbiologics
• <b>Bio-Integrated Interfaces for Human-Machine Interaction: Sensing, Actuation, and Computing</b>
  The rapid advancement of artificial intelligence has fundamentally reshaped the ambition of human-machine interaction—yet the physical interfaces through which machines perceive humans and respond to them remain a critical bottleneck. Realizing intelligent, em…
  datacite Deng, Pengfei 2026 置信度 0.66 BiomaterialsBiomechatronicsEnergy-efficient computingHuman-computer interactionElectronics, sensors and digital hardware not elsewhere classified
• <b>Bio-Integrated Interfaces for Human-Machine Interaction: Sensing, Actuation, and Computing</b>
  The rapid advancement of artificial intelligence has fundamentally reshaped the ambition of human-machine interaction—yet the physical interfaces through which machines perceive humans and respond to them remain a critical bottleneck. Realizing intelligent, em…
  datacite Deng, Pengfei 2026 置信度 0.66 BiomaterialsBiomechatronicsEnergy-efficient computingHuman-computer interactionElectronics, sensors and digital hardware not elsewhere classified
• Efficient biomanufacturing of vitamin E succinate in non-aqueous media via synergistic computational evolution and immobilization of lipase
  datacite zhang, Zihan, Zhang, Yu, Liu, Qingqing, Song, Wanqing 等 2026 置信度 0.66
• Human Induced Pluripotent Stem Cell-Derived Committed Cardiac Progenitors Generate Cardiac Tissue Grafts in a Swine Ischemic Cardiomyopathy Model Without Triggering Ventricular Arrhythmias.
  Intramyocardial injection of human pluripotent stem cell-derived cardiomyocytes after myocardial infarction improves cardiac function in large animal models, but associated ventricular arrhythmias are a major safety concern. We hypothesized that transendocardi…
  pubmed Raval AN, Schmuck EG, Leonov V, Roy S 等 2026 Aug 4 置信度 0.82
• Efficient, complete biosynthesis of isoflavonoid calycosin-7-glucoside by metabolically engineered yeast cell factories.
  Plant isoflavonoids constitute a class of secondary metabolites that hold great potential in nutraceutical and pharmaceutical industries, considering their prominent human health-promoting properties. As a result, there is increasing interest in establishing a…
  pubmed Zhang W, Xu M, Wang L, Qiao X 等 2026 置信度 0.82
• Corrigendum to "Evolution of pyraclostrobin resistance in Botrytis cinerea from Xinxiang City of China and its targeted management via RNA interference" [Pesticide Biochemistry and Physiology 221 (2026) 107105].
  pubmed Zhou F, Su H, Jia H, Liu T 等 2026 Aug 置信度 0.82
• Microbiota-Targeted Chitooligosaccharides Intervention Restores Glucose Homeostasis After Islet Cell Transplantation in Rapamycin-Treated Mice.
  Islet cell transplantation (ICT) is an effective treatment for diabetes mellitus, but postoperative islet function recovery and inflammation are closely linked to immunosuppressants. Using multi-omics and fecal microbiota transplantation (FMT) in human microbi…
  pubmed Chang K, He D, Dong J, Zhang Y 等 2026 Jul 置信度 0.82
• CRISPR-Cas regulates expression of embedded anti-phage defence systems.
  Bacteria utilize diverse defence systems to protect against harmful foreign DNA such as bacteriophages 1,2 , but how these systems coordinate with each other remains poorly understood. Here we uncover CRISIS (CRISPR-supervised immune system), a widespread regu…
  pubmed Shu X, Wang R, Zhou X, Cheng F 等 2026 Jul 22 置信度 0.82
• [MBD1 knockdown inhibits proliferation, migration and angiogenesis of human umbilical vein endothelial cells in vitro].
  To investigate the effects of methyl-CpG binding domain protein 1 (MBD1) on proliferation, migration, and angiogenesis in human umbilical vein endothelial cells (HUVECs).
  pubmed Dan Y, Zhang T, Liu H, Zhang P 2026 Jul 20 置信度 0.82
• Recent Advances in The Microbial Synthesis of (-)-α-Bisabolol: Pathway, Enzymes and Strategies.
  &#x3b1;-Bisabolol, a natural sesquiterpene alcohol with notable physiological activities, exhibits broad application prospects in the pharmaceutical, cosmetic, and flavor industries. Traditional plant extraction suffers from low efficiency and resource scarcit…
  pubmed Xiao J, Li Z, Zhang J, Zhu Y 等 2026 置信度 0.82
• Condensates of the chromatin regulator ANKRD11 restrict hypertranscribed genes to safeguard development.
  Genes that define cell identity are often highly transcribed, but how their activity is regulated to prevent pathological dysregulation remains elusive. Using a two-tiered genetic screen, we identify a network of genes regulating hypertranscribed loci, which i…
  pubmed Zhang T, Li X, Zhou W, Li ZL 等 2026 Jul 22 置信度 0.82
• Bioproduction potential from industrial and municipal waste streams through open-culture biotechnology.
  Widespread municipal and industrial feedstocks rich in organics are potential feedstocks for allocating biogenic carbon into circular bioproducts through open-culture biotechnology. In this work, we estimate the production potential of selected biochemicals (m…
  pubmed Servin-Balderas I, Wetser K, Hamelers B, Buisman CJN 等 2026 Aug 1 置信度 0.82
• Describing the persistence landscape for introducing microbes into complex communities.
  Introducing non-native organisms into natural or designed microbial communities holds enormous potential but faces challenges in establishment, persistence, and containment. We propose the "persistence landscape"-the functional composition of a target microbio…
  pubmed McDermott JE, Nelson WC, Zimmerman AE, Anthony W 等 2026 Aug 19 置信度 0.82
• Host-directed iminosugars MON-DNJ and NB-DNJ inhibit measles virus and human respiratory syncytial virus replication in vitro.
  Measles virus (MeV) and human respiratory syncytial virus (HRSV) remain significant causes of global morbidity and mortality; measles in unvaccinated children, HRSV in infants below 6 months, immunocompromised, and the elderly. Despite the availability of vacc…
  pubmed van Dijk LLA, Schmitz KS, Barbaglia MN, Magri A 等 2026 Sep 置信度 0.82
• Polyphasic taxonomy of glacier-derived Arthrobacter strains reveals six novel species within the Arthrobacter agilis group and indicates Arthrobacter vasquezii Valenzuela-Ibaceta et al. 2023 as a later heterotypic synonym of Arthrobacter parietis Heyrman et al. 2005.
  Eight bacterial strains assigned to the genus Arthrobacter by preliminary 16S rRNA gene screening were isolated from supraglacial samples collected from four glaciers in China. Genome-based analyses provided the primary evidence for species delineation. Pairwi…
  pubmed Yang LL, Xin YH, Liu Q 2026 Jul 置信度 0.82
• Gene Editing-Driven Engineering of Microbial Systems and Metabolites for Precision Medicine and Sustainable Environmental Remediation.
  The engineering of microorganisms is undergoing a fundamental paradigm shift, transitioning from the construction of static cell factories to the programming of dynamically responsive living materials. However, translating molecular interventions into robust m…
  pubmed Du Y, Shi Y, Chen D, Wang S 等 2026 置信度 0.82
• Establishing a Microbial Platform for Aromatic Lactones Production From Glucose.
  Aromatic lactones, including Homogentisate-&#x3b3;-lactone, 2-coumaronone, and coumarin, have broad applications in pharmaceuticals and agrochemicals, due to their antimicrobial, anti-inflammatory, and antioxidant activities. However, their industrial producti…
  pubmed Li S, Wang T, Li G, Sun M 等 2026 Jul 21 置信度 0.82
• Towards an enzyme cascade synthesis of the bulk chemical acrylic acid.
  Acrylic acid is a bulk chemical predominantly produced via fossil-based processes. Here, we repurpose and engineer a thiamine diphosphate (ThDP)-dependent enzyme to catalyze direct H 2 PO 4 - elimination from dihydroxyacetone phosphate (DHAP) for acrylic acid …
  pubmed Zhao H, Wang C, Zhang S, Wang Q 等 2026 Jul 21 置信度 0.82
• Substrate-informed metabolic engineering enables a genome-encoded seven-sugar chassis of Corynebacterium glutamicum for spent sulfite liquor valorization.
  Efficient microbial conversion of heterogeneous carbohydrate mixtures remains a central bottleneck in industrial biotechnology, yet scalable chassis architectures capable of coordinated multi-sugar utilization are limited. Recently, substrate-informed metaboli…
  pubmed Cao P, Kohlstedt M, Christmann J, Schwechheimer S 等 2026 置信度 0.82
• Morphology-Engineered Ceria Nanoparticles Ameliorate Periodontitis via Enhanced Antioxidant and Anti-Inflammatory Activities.
  Periodontitis is a chronic inflammatory oral disease featured with continuous alveolar bone resorption, where a ccumulated reactive oxygen species (ROS) aggravate tissue damage and local inflammation. Ceria nanoparticles (CNPs) act as promising redox nanozymes…
  pubmed Jin S, Tang H, Yu Y, Zhang Z 等 2026 Jul 19 置信度 0.82
• Technoeconomic and life-cycle assessment of multi-product and single-product lignocellulosic biorefineries.
  This study compares technoeconomic analysis (TEA) and life-cycle assessment (LCA) for single-product and multi-product biorefineries producing ethanol, butanol, itaconic acid (IA), and 3-hydroxypropionic acid (3-HP) from brewer's spent grain. Single-product bi…
  pubmed Babaei S, Philips L, Lee J, Oh EJ 等 2026 置信度 0.82
• Process-integrated engineered resting cells for biocatalytic production of rare natural sugars from sole methanol molecules.
  The biocatalytic conversion of green methanol, a promising feedstock, into high value-added products is seen as an attractive way to establish sustainable biomanufacturing. Although natural and engineered microorganisms can utilize methanol, efficiently conver…
  pubmed Wang Y, Liu G, Gao F, Zhang H 等 2026 Jul 18 置信度 0.82
• Optimizing artificial induction and standardized production of egg branches for Cryptotympana atrata in poplar plantations.
  The golden cicada (Cryptotympana atrata) is an economically important insect in China, but the expansion of its artificial cultivation is limited by an unstable supply of high-quality egg branches used for propagation. To develop a standardized system for egg-…
  pubmed Zhou Y, Yin X, Amir Khan M, Deng Z 2026 Jul 18 置信度 0.82
• Engineered lipase enables selective hydrolysis of palmitic over oleic acyl chains at a two‑phase microfluidic interface.
  The fatty acid chain length of lipids plays a pivotal role in determining their nutritional value and industrial applicability. However, the synthesis of functional lipids with defined fatty acid compositions is often limited by the insufficient chain-length s…
  pubmed Wang JZ, Tan L, Wu CK, Wang XY 等 2026 Jul 18 置信度 0.82
• Protocol for high-throughput droplet-engineered TIL-retaining tumor organoids in triple-negative breast cancer.
  Here, we present a protocol for generating high-throughput, droplet-engineered tumor organoids from triple-negative breast cancer (TNBC) tissues using the OrgFab&#xae; micro-sphere printing system. We describe tumor dissociation, bioink preparation, and automa…
  pubmed Zhou X, Zhu Y, Wang W, Cai Y 等 2026 Jul 17 置信度 0.82
• Interfacing microorganisms with synthetic materials toward augmented light-driven chemical production.
  Solar-driven conversion of abundant small molecules such as H 2 O, CO 2 and N 2 into value-added chemicals represents an attractive strategy for sustainable energy utilization and green manufacturing. Integrating microorganisms with functional materials has em…
  pubmed Chen Y, Fu L, Wang W 2026 置信度 0.82
• Multi-module immobilization of Gluconobacter frateurii alcohol dehydrogenase and Lactobacillus brevis NADH oxidase with tethered nicotinamide adenine dinucleotide for D-allulose biosynthesis.
  The green biomanufacturing of high-value compounds is limited by enzyme instability and cofactor dependence. Herein, we developed a tailored multi-module immobilization strategy that integrated cofactor tethering with sequential multi-enzyme co-immobilization …
  pubmed Ai J, Yan J, Zhang Y, Lu F 等 2026 Jul 17 置信度 0.82
• Enhancing recombinant eGFP secretion in P. tricornutum by optimizing culture conditions.
  Phaeodactylum tricornutum is a promising candidate for the production of recombinant therapeutic proteins including antibodies. So far, low secretion yields remain a significant bottleneck for pharmaceutical applications. Towards the objective to increase prod…
  pubmed Gargouch N, Charrier A, Toustou C, Bougaran G 等 2026 Jul 16 置信度 0.82
• IncuSense: IoT-Enabled Wireless Long-Term Multiparametric Cell Culture Incubator Monitoring System.
  Cell-culture incubators are indispensable for in vitro research and new approach methods (NAMs), yet they remain vulnerable to undetected environmental fluctuations that degrade experimental reproducibility and compromise biological sample integrity. Existing …
  pubmed Kumar A, Patel R, Johnson D, Jain A 2026 Jul 16 置信度 0.82
• Engineered Peptide Hydrogel Interface for Coupling Rapid Stemness Induction, In Situ Pathway Monitoring, and Direct Drug Evaluation of Cancer Stem Cells.
  Cancer stem cell (CSC) models are essential for understanding tumor progression and evaluating targeted therapies. However, conventional approaches rely on sphere formation, destructive characterization, and re-culture steps, resulting in prolonged workflows a…
  pubmed Wei X, Zhou Y, Yang Z, Lin W 等 2026 Aug 5 置信度 0.82
• Peptidoglycan-loaded PLGA-PVA nanoparticles sustain NOD2 and IFN-γ transcription in NK-92 cells beyond nanoparticle withdrawal.
  Effective immunomodulation of natural killer (NK) cells holds promise for enhancing innate immune responses in cancer and infectious diseases; however, free immunostimulants often induce only transient activation. In this study, we developed peptidoglycan (PG)…
  pubmed Baburajan AP, Pradeep A, Abhitha K, Bhat SG 等 2026 Jul 16 置信度 0.82
• Purification of Advanced Therapeutics by Flow-Through Pseudo-Affinity Chromatography: Bi-Specific mABs, Fc Fusion Proteins, and Adeno-Associated Viruses.
  Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high-risk host cell proteins (HCPs). Current purification proc…
  pubmed Chu W, Barbieri E, Minzoni A, Shastry S 等 2026 Jul 16 置信度 0.82
• Horizontal acquisition of nicotine catabolism gene cluster enhances Arthrobacter fitness within tobacco root microbiota.
  Plant roots are hotspots for interactions with soil microbes, where a characteristic bacterial community structure is formed. Plant specialized metabolites often play pivotal roles in this assembly process. However, the molecular basis underlying root microbio…
  pubmed Shimasaki T, Nose Y, Masuda S, Shibata A 等 2026 Jul 15 置信度 0.82
• Description of nine novel psychrophilic Pseudarthrobacter species from glaciers.
  Eleven glacier-derived bacterial strains, represented by the type strains HZ3 T , TMT1-37 T , TMS2-18 T , TMN-17 T , TMN-24 T , MDT1-20 T , MDT3-30 T , HLT3-6 T and MDT3-24 T , were isolated from cryoconite samples collected from glaciers in China. These strai…
  pubmed Yang LL, Xin YH, Liu Q 2026 Jul 置信度 0.82
• Shrinky Dinks-Based Bionic Meta-Microneedles for Advancing Wound Healing.
  Wound healing remains a fundamental and enduring challenge in healthcare. Among emerging approaches, microneedle (MN) dressings represent a promising strategy for improving wound treatment. Here, inspired by frog foot pads and octopus suction cups, we propose …
  pubmed Wu T, Yuan P, Pan Y, Xie C 等 2026 置信度 0.82
• Spore-Forming Probiotic-Embedded Biomaterials for Targeted Gut Microplastic Biodegradation.
  Microplastic (MP) exposure compromises gut barrier integrity, microbial homeostasis, and host immunity to accelerate mucosal dysfunction and disease progression. This necessitates new strategies to address gut MP accumulation concerns. Unlike environmental set…
  pubmed Nicolas GM, Yuan T, Rukmana A, Zhang Z 等 2026 Jul 10 置信度 0.82
• Cold-Resistance Plasticizers Derived from Bio-Based Trans-Aconitic Acid with High Performance on Solvent Extraction Resistance and Volatility Resistance.
  Dioctyl adipate (DOA) and dioctyl sebacate (DOS) are widely used cold-resistance plasticizers; however, their low molecular weight and weak polarity result in poor thermal stability and migration resistance. Here, we report the synthesis and performance of bio…
  pubmed Shen Y, Wang X, Xiong Y, He X 等 2026 Jul 6 置信度 0.82
• Programmable Microcarriers for Stem Cell Therapy: Advanced Fabrication Strategies, Stem Cell Fate Regulatory Function and Biomedical Applications.
  Stem cells, with their self-renewal and multi-lineage differentiation potential, hold promise for tissue repair and intractable diseases treatment. Yet clinical translation of stem cell therapies has long been hindered by insufficient scalable stem cell manufa…
  pubmed Wang Y, Hu C 2026 置信度 0.82
• Transparent polypyrrole-nanocellulose hydrogel electrodes with durable skin adhesion for wearable ECG monitoring.
  Skin-adhered electrocardiography (ECG) demands electrodes that maintain low and stable skin-electrode coupling during motion while remaining soft, adhesive, and, ideally, transparent for accurate placement. However, conductive hydrogels rarely combine optical …
  pubmed Zheng G, Yu Y, Shan C, Guo Y 等 2026 Dec 15 置信度 0.82
• Base-Catalyzed Diversity-Orientated Synthesis of Tetra-/Dihydrothiophenecarboxamides and Preliminary Evaluation as Antifungal Agents.
  Here, we report a facile and mild method for the diverse synthesis of tetra-/dihydrothiophenecarboxamide derivatives ( 3-6 ) via base-initiated [3 + 2] cycloaddition reactions of 1-carbonyl cyclopropanecarboxamides ( 1 ) with isothiocyanates ( 2 ) using EtOH a…
  pubmed Wang J, Hu J, Fu J, Yang F 等 2026 Jul 24 置信度 0.82
• Controlled Delivery of Gasotransmitters for Cardiovascular Therapy: Molecular Mechanisms, Engineered Platforms, and Translational Perspectives.
  Gasotransmitters, including nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H 2 S) exert broad cardioprotective effects by regulating vascular function, inflammatory signaling, oxidative stress, mitochondrial homeostasis, and myocardial remodeli…
  pubmed Zhu Y, Chen R, Ren H, Li X 等 2026 置信度 0.82
• Microbial conversion of biodiesel waste for carotenoid production.
  Enhanced production of isoprenoid compounds, including carotenoids, is needed to meet the growing demand in the food, cosmetic, pharmaceutical, and biotechnology sectors. Haloferax volcanii represents a promising microbial platform for sustainable isoprenoid p…
  pubmed Weber KR, Chu Z, Desai H, Cox N 等 2026 置信度 0.82
• A Biomimetic Nanocomposite Hydrogel Cross-Linked by Calcium Phosphate Oligomers for Bone Regeneration.
  Conventional gelatin (Gel) and alginate hydrogels possess excellent biocompatibility. Their high water content and three-dimensional porous structure mimic the extracellular matrix, facilitating nutrient transport and metabolic waste removal. However, their ap…
  pubmed Liu L, Li K, Yan Z, Xia C 等 2026 Aug 3 置信度 0.82
• P2-engineered exosomes encapsulating curcumin alleviate cognitive decline in AD-like mice by improving microglia-related neuropathology.
  Natural exosomes, as drug carriers, can deliver anti-inflammatory agents across the blood-brain barrier (BBB) to lesion sites in the brain, thereby demonstrating immense potential in the treatment of brain inflammation-related diseases. However, the applicatio…
  pubmed Huang X, Xu G, Zhou Y, Wang D 等 2026 Aug 置信度 0.82
• Controlled Synthesis of Chiral β-Chloramines and Aziridines via an Organo- and Biocatalytic Cascade.
  Chiral organochlorides bearing C-Cl stereocenters are highly desirable motifs in synthetic and medicinal chemistry, yet their direct asymmetric synthesis from simple starting materials via biocatalysis alone remains challenging. Here, we report an integrated o…
  pubmed Zhu ZY, Xia ZW, Huang ZY, Zou YZ 等 2026 Jul 29 置信度 0.82
• Branch architecture and flowering time are separately regulated by GhFL and GhSP2 in cotton.
  Crop flowering, a critical aspect of plant growth, is influenced by genetic and environmental factors. The indeterminate growth of cotton can lead to asynchronous flowering and boll setting. This study identified and characterized a determinate growth mutant, …
  pubmed Guan Z, Cai Q, Miao P, Cheng H 等 2026 Jul 置信度 0.82
• AI-powered the toughest biohydrogels.
  Hydrogel soft materials hold immense promise for applications ranging from bionic soft robots to flexible human-machine interfaces, but realizing this potential critically depends on excellent mechanical properties. While substantial progress has been made in …
  pubmed Yang J, Fu T, Yao K, Kong W 等 2026 Dec 置信度 0.82
• The role of computational cellular models in industrial bioprocesses: From genetic engineering to plant design.
  Engineering cellular metabolism has enabled bioprocesses to manufacture sustainable fuels, materials, foods, commodity chemicals, and pharmaceuticals. Yet much of this potential remains unrealized because cellular behavior is complex and decisions must be coor…
  pubmed Garcia S 2026 置信度 0.82
• Small RNA sequencing unveils predominant expression patterns and miRNA-target modules associated with seed development in sorghum.
  Sorghum is a prominent cereal crop of global importance. Advancements in seed research are essential to enhance seed yield and nutritional value in sorghum. Here, we report small RNA profiling from five stages of sorghum seed development, depicting miRNA dynam…
  pubmed Jain R, Yadav G, Dhaka N, Vashisht I 等 2026 Jul 置信度 0.82
• Deep Learning-driven synergistic engineering of PET hydrolase for post-consumer PET depolymerization.
  Enzymatic depolymerization of polyethylene terephthalate (PET) offers a promising route to mitigate the increasingly severe problem of plastic pollution. However, the development of highly efficient PET hydrolases capable of processing post-consumer PET remain…
  pubmed Shao C, Shen X, Long J, Cui Z 等 2027 Jan 置信度 0.82
• Metabolic state-driven monitoring and control of abnormal pigment formation in sodium gluconate fermentation by Aspergillus niger.
  Abnormal pigment formation during late-stage fungal fermentation poses a significant challenge to industrial product quality. This study established an integrated framework to understand and control pigmentation in Aspergillus niger sodium gluconate fermentati…
  pubmed Sun J, Jiang Y, Jiang X, Chen Z 等 2027 Feb 置信度 0.82
• Volatile organic compounds from Bacillus sp. PAR690 Promote plant growth by regulating photosynthesis and nitrogen metabolism.
  Plant growth-promoting bacteria (PGPB) enhance plant growth through multiple mechanisms; however, the underlying plant molecular response pathways remain insufficiently understood, particularly those mediated by bacterial volatile organic compounds (VOCs). In …
  pubmed Yang Y, Jin J, Liu R, Wang X 等 2026 Jul 10 置信度 0.82
• Transcriptome and flavor metabolism analysis revealed the key metabolic pathways for aroma enhancement of Aspergillus Fuqu under agarwood addition.
  Enhancing the quality of Fuqu, a traditional fermentation agent used in Baijiu production, is crucial for aroma enrichment of Baijiu to address the thin aroma caused by a single microbial species in fermentation. The physicochemical factors and enzymatic, flav…
  pubmed Guo Z, Li Z, Zhu M, Wang M 等 2026 Nov 置信度 0.82
• Photocatalytic Markovnikov-Selective Sulfonation of Alkynes for Indoline Synthesis.
  The indoline scaffold, a privileged class of nitrogen-containing heterocycles, is ubiquitous in bioactive natural products and pharmaceuticals; consequently, the development of efficient synthetic strategies remains a forefront of organic synthesis. Herein, we…
  pubmed Huang YW, Bai JL, Yu D, Zhou SL 等 2026 Jul 24 置信度 0.82
• Protocol to purify human and mouse cytokines using an endotoxin-free Escherichia coli-based platform.
  Here, we present a cost-effective protocol to purify four representative human and mouse cytokines using an endotoxin-free Escherichia coli (E. coli)-based platform. We describe steps for protein expression and maltose-binding protein (MBP) tag removal. We the…
  pubmed Kim JY, Xin J, Kuo IC, Chen SX 等 2026 Jul 9 置信度 0.82
• Rational selection of ketopantoate hydroxymethyltransferase with low product feedback inhibition based on binding free energy calculation analysis.
  The microbial production of pantothenic acid (d-PA) is critically limited by feedback inhibition and low activity of the key enzyme ketopantoate hydroxymethyltransferase (KPHMT). To overcome this, rational enzyme mining based on computational prediction was es…
  pubmed Zheng K, Pang A-P, Zhu F-Y, Liu Y-H 等 2026 Aug 19 置信度 0.82
• Harnessing the PpHog1 Regulatory Network to Engineer a UPR-Adaptive Komagataella phaffii Chassis for High-Copy Secretory Protein Production.
  Komagataella phaffii is one of the most widely used eukaryotic protein expression systems. Increasing the copy number of exogenous genes is a common method to enhance expression efficiency. However, at extremely high copy numbers, the resulting endoplasmic ret…
  pubmed Shi J, Lv Z, Lu C, Fang B 等 2026 Jul 置信度 0.82
• Endogenous 6-phospho-β-glucosidase overexpression in Lactiplantibacillus plantarum modulates selective enrichment of bioactive and volatile metabolites in black tea extract.
  Rich in sequestered glycosidic precursors, black tea serves as a model to deconvolve the cooperative biotransformation between microbial metabolism and endogenous catalysis. Herein, Lactiplantibacillus plantarum strains overexpressing specific endogenous 6-pho…
  pubmed Zhang YZ, Cheng ZP, Feng PY, Liu XX 等 2026 Dec 置信度 0.82
• Mechanically locking enzymes in covalent organic frameworks via light-responsive nanohands for stable biocatalysis.
  Enzyme immobilization is pivotal to sustainable biocatalysis, yet the most widespread protocol of physical adsorption on static porous supports suffers from enzyme leakage and short catalytic lifespan. We introduce a dynamic-pore mechano-locking strategy emplo…
  pubmed Wang T, Xin R, Qian Y, Zhou H 等 2026 Jul 7 置信度 0.82
• Pioneering the formation of 2-carboxylic anthraquinone: CRISPR/Cas9-mediated functional validation of Octaketide synthase and Polyketide reductase genes in Aloe vera.
  Aloe vera is an authentic medical plant abundant in aromatic polyketides, including the crucial hexaketides aloenin, aloesin, and barbaloin used in pharmaceuticals, yet the enzymatic basis of their biosynthesis remains incompletely understood. While it has bee…
  pubmed Jangra A, Tiwari S, Chhokar V 2026 Sep 置信度 0.82
• Sequential H(2)S-Triggered Redox Relay Nanoprobes for Self-Sustained Chem-Illuminating Cascade Photodynamic Therapy.
  Endogenous chemiluminescence offers a transformative approach to photodynamic therapy that circumvents the limited penetration of external light and enables tumor-selective activation. However, most chemiluminescence-driven photodynamic therapy (CL-PDT) system…
  pubmed Yang J, Lu Y, Zhang Y, Zhao X 等 2026 Jul 7 置信度 0.82
• Research progress on the biological activity and applications of gamma-aminobutyric acid.
  Gamma-aminobutyric acid (GABA) is a four&#x2011;carbon, non-proteinogenic amino acid widely found in vertebrates, plants, and tiny critters. This compound acts as the primary inhibitory neurotransmitter in the nervous system. Recent studies have shown that the…
  pubmed Tan Z, Dai Q, Shen L, Lei Y 等 2026 Sep 30 置信度 0.82
• GhCHX6A and GhKEA1D Enhance Salt Tolerance by Regulating Na(+)/K(+) Homeostasis in Cotton.
  The cation/proton antiporter (CPA2) family plays key roles in regulating plant ion balance and pH homeostasis, particularly in response to salt stress. In this study, a total of 76 CPA2 members were identified in Gossypium hirsutum, phylogenetically classified…
  pubmed Zhu Q, Miao Y, Wang Y, Zhang Z 等 2026 Jul-Aug 置信度 0.82
• Editorial for "Association of Iron and Myelin Alterations in the Contralesional Dentate Nucleus and Thalamus With Functional Outcome in Acute Ischemic Stroke: A Susceptibility Source Separation Study".
  pubmed Chen Y, Wang D 2026 Jul 5 置信度 0.82
• Non-sterile fermentation of butyl butyrate by Clostridium tyrobutyricum with an anti-microbial contamination system.
  Microbial contamination is a major challenge in industrial fermentation, while conventional sterilization is energy-intensive and costly. Here, an anti-contamination system was developed in Clostridium tyrobutyricum for non-sterile production of butyl butyrate…
  pubmed Wang Y, Ren C, Fang C, Yang Z 等 2026 Jul 4 置信度 0.82
• Biosensors with enzymatic amplification strategies for the detection of foodborne pathogenic microorganisms.
  Foodborne pathogenic microorganisms pose serious threats to public health, underscoring the critical need for rapid detection methods. Biosensors serve as promising alternatives by integrating biorecognition elements with signal transduction systems, enabling …
  pubmed Yu M, Jiang W, Cui X, Feng R 等 2026 Nov 置信度 0.82
• Rapid species authentication and protein prediction of porcini mushrooms using FTIR-2DCOS coupled with deep learning.
  Edible fungi are highly valued worldwide for their unique culinary and therapeutic properties. Nevertheless, the pronounced morphological similarities among commercially dehydrated species constantly provoke market misclassification, leading to severe fluctuat…
  pubmed Zheng C, Liu H, Li J, Wang Y 2026 Dec 15 置信度 0.82
• Active Pocket Engineering of d-Tagatose 4-Epimerase for Improved Catalytic Performance and Efficient Cascade Synthesis of d-Tagatose from d-Glucose.
  d-Tagatose is a rare hexose sugar with excellent properties, and its synthesis catalyzed by d-tagatose 4-epimerase (T4E) represents a competitive novel pathway. In this study, Eb T4E derived from the Eubacteriales bacterium was screened and systematically char…
  pubmed Zhang YS, Li ZQ, Chen JH, Dong SA 等 2026 Jul 15 置信度 0.82
• Spatiotemporal temperature trajectories underpin predictive modeling of microbial succession in single-batch high-temperature daqu solid-state fermentation.
  Spontaneous solid-state fermentation (SSF) efficiency and product quality depend on microbial consortia regulation under dynamic temperature regimes, yet how spatially heterogeneous temperature trajectories are linked to community assembly, volatile profiles, …
  pubmed Fu JJ, Shi W, Shen HJ, Yang SB 等 2026 Jul 3 置信度 0.82
• Caldifarcimen microaerophilum gen. nov., sp. nov., a facultatively anaerobic, thermophilic bacterium of a novel bacterial phylum, Caldifarciminota phyl. nov., formerly called candidate phylum WOR-3, description of Caldifarciminaceae fam. nov., Caldifarciminales ord. nov. and Caldifarciminia classis nov.
  A facultatively anaerobic, thermophilic, Gram-negative bacterium, strain sy37 T , isolated from a deep-sea hydrothermal field and belonging to the candidate phylum WOR-3, was characterized in detail. The cells were non-motile long rods with pili and grew via r…
  pubmed Mori K, Hidaka K, Tamazawa S, Hosoyama A 等 2026 Jul 置信度 0.82
• Development and characterization of a Cre/loxP toolkit for genome engineering in Komagataella phaffii.
  The Cre/ loxP system is a versatile tool for genome engineering, yet its application in the industrial yeast Komagataella phaffii has been limited primarily to marker recycling. This study reports a comprehensive Cre/ loxP toolkit for K. phaffii . The N-termin…
  pubmed Song L, Hua L, Wu Y, Jiang X 等 2027 Jan 置信度 0.82
• Development of a CRISPRi system in Fusarium fujikuroi and its application in gibberellic acid production.
  Gene knockdown is a pivotal genetic manipulation technique, particularly when targeting lethal genes or genes involved in product synthesis pathways, where complete gene knockout is not a viable option. This approach is particularly valuable in multinucleate s…
  pubmed Cen Y, Xiao H, Jia J, Mou J 等 2026 Jun 置信度 0.82
• Overexpression of Arabidopsis BBX11 confers enhanced cold tolerance and alters stress-responsive transcriptional networks.
  B-box (BBX) transcription factors play critical roles in plant acclimation to environmental stresses, yet their involvement in cold stress responses remains incompletely understood. Following a genome-wide analysis of BBX gene expression profiles in Arabidopsi…
  pubmed Chen HY, Kitwetch B, Wang WJ, Yeh KL 等 2026 Jun 25 置信度 0.82
• [Exploring innovative approaches by Zhu Xitao to promote the modernization and internationalization of Chinese stomatology].
  In the mid-20th century, dental education in China was in a critical period of transformation from traditional dentistry to modern stomatological education. Based on archival materials, academic works, memoirs and interview data, this paper systematically sort…
  pubmed Jie HF, Shan YH, Zhou YS 2026 Jul 9 置信度 0.82