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• Biología sintética en relación con la conservación de la naturaleza: documento informativo
  crossref 2024-03-13T20:45:19Z 置信度 0.70
• Inter-molecular Binding Affinity Synthetic Data Augmentation Transforms the Landscape of Computational Biomolecule Design and Discovery
  The advancement of computational drug discovery and design necessitates continuous innovation to enhance the accuracy and scope of predictive models for early-stage drug research and development. This article introduces a novel workflow for in silico generatio…
  crossref Wei Li 2024-08-26T01:00:31Z 置信度 0.70
• Quantitative synthetic biology
  crossref Nan Luo, Guoping Zhao, Chenli Liu 2024-07-24T05:02:47Z 置信度 0.70
• Kermut: Composite kernel regression for protein variant effects
  Abstract Reliable prediction of protein variant effects is crucial for both protein optimization and for advancing biological understanding. For practical use in protein engineering, it is important that we can also provide reliable uncertainty estimates for o…
  crossref Peter Mørch Groth, Mads Herbert Kerrn, Lars Olsen, Jesper Salomon 等 2024-05-30T02:35:42Z 置信度 0.70
• Multifunctional Liposomes Co-Modified with Ginsenoside Compound K and Hyaluronic Acid for Tumor-Targeted Therapy
  Liposomes show promise for anti-cancer drug delivery and tumor-targeted therapy. However, complex tumor microenvironments and the performance limitations of traditional liposomes restrict clinical translation. Hyaluronic acid (HA)-modified nanoliposomes effect…
  crossref Xiaoyan You, Hui Liu, Yue Chen, Guoping Zhao 2024-02-01T09:04:21Z 置信度 0.70
• Synthetic MRI in action: A novel framework in data augmentation strategies for robust multi-modal brain tumor segmentation
  crossref Kaliprasad Pani, Indu Chawla 2024-10-23T07:09:44Z 置信度 0.70
• Cell-free synthetic biology: Navigating the new frontiers of biomanufacturing and biological engineering
  crossref So Jeong Lee, Dong-Myung Kim 2023-11-21T00:58:55Z 置信度 0.70
• Impact of Synthetic Biology in Point-of-Care Diagnostics
  crossref Sanchao Liu, Alexander Winton, Matthew Coppock 2024-12-09T12:37:08Z 置信度 0.70
• Role of synthetic biology to build a sustainable vaccine industry
  crossref Sai Bhavani Gottumukkala, Pushkar Malakar, Anbumathi Palanisamy 2024-05-17T07:59:04Z 置信度 0.70
• The synthetic chemistry of sarpagine–ajmaline-type alkaloids
  crossref 2024-09-24T09:03:51Z 置信度 0.70
• Rapid <i>in vitro</i> method to assemble and transfer DNA fragments into the JCVI-syn3B minimal synthetic bacterial genome through Cre/ <i>loxP</i> system
  Abstract JCVI-syn3B (syn3B), a minimal synthetic bacterium that only possesses essential genes, facilitates the examination of heterogeneous gene functions in minimal life. Conventionally, Escherichia coli is used to construct DNA fragments for gene transfer i…
  crossref Atsuko Uenoyama, Hana Kiyama, Mone Mimura, Makoto Miyata 2024-08-02T01:05:15Z 置信度 0.70
• A synthetic cell-free pathway for biocatalytic upgrading of one-carbon substrates
  Abstract Biotechnological processes hold tremendous potential for the efficient and sustainable conversion of one-carbon (C1) substrates into complex multi-carbon products. However, the development of robust and versatile biocatalytic systems for this purpose …
  crossref Grant M. Landwehr, Bastian Vogeli, Cong Tian, Bharti Singal 等 2024-08-08T23:55:23Z 置信度 0.70
• Revolutionizing Point-of-Care Diagnostics via CRISPR Systems
  crossref Magdy Mahfouz 2024-01-10T10:56:10Z 置信度 0.70
• Enhancing Gastrodin Production in Yarrowia lipolytica by Metabolic Engineering
  ABSTRACT Gastrodin, 4-hydroxybenzyl alcohol-4-O-β-D-glucopyranoside, has been widely used in the treatment of neurogenic and cardiovascular diseases. Currently, gastrodin biosynthesis has been achieved in model microorganisms. However, the production levels ar…
  preprints Yuanqing Wu, Shuocheng Li, Baijian Sun, Jingyi Guo 等 2024 置信度 0.74
• The Importance of Biosecurity in Emerging Biotechnologies and Synthetic Biology
  The age of synthetic biology is ushering in new technologies for the advancement of society, human health, and agriculture. It appears that synthetic biology has integrated engineering paradigms into biological contexts. The combined use of new biotechnology a…
  crossref Mahboubeh Soleimani Sasani 2024-10-19T14:46:10Z 置信度 0.70
• Sequencing Strategy to Ensure Accurate Plasmid Assembly
  Despite the wide use of plasmids in research and clinical production, verifying plasmid sequences is a bottleneck often underestimated in the manufacturing process. While sequencing platforms continue to improve, the chosen method and assembly pipeline still s…
  crossref Sarah I Hernandez, Casey-Tyler Berezin, Katie M Miller, Samuel J Peccoud 等 2024-03-26T23:55:16Z 置信度 0.70
• Analysing the Contribution of Research Centres in Synthetic Biology to Transformative Innovation. Insights from Australia and the UK
  crossref Artem Anyshchenko, Rachel Parker 2024-11-05T16:56:20Z 置信度 0.70
• AC-BioSD : A biomolecular signal differentiator module with enhanced performance (extended version)
  Abstract Temporal gradient estimation is a pervasive phenomenon in natural biological systems and holds great promise for synthetic counterparts with broad-reaching applications. Here, we advance the concept of BioSD ( Biomolecular Signal Differentiators ) by …
  crossref Emmanouil Alexis, José L. Avalos, Luca Cardelli, Antonis Papachristodoulou 2024-01-30T23:25:25Z 置信度 0.70
• Computational pipeline for targeted integration and variable payload expression for bacteriophage engineering
  Abstract Bacteriophages offer a promising alternative to conventional antimicrobial treatments, particularly in cases where such treatments have proven ineffective. While naturally occurring phages serve as viable options for phage therapy, advances in synthet…
  crossref Jonas Fernbach, Emese Hegedis, Martin J. Loessner, Samuel Kilcher 2024-06-18T01:45:10Z 置信度 0.70
• Pore engineering as a general strategy to improve protein-based enzyme nanoreactor performance
  Abstract Enzyme nanoreactors are nanoscale compartments consisting of encapsulated enzymes and a selectively permeable barrier. Sequestration and co-localization of enzymes can increase catalytic activity, stability, and longevity, highly desirable features fo…
  crossref Seokmu Kwon, Michael P. Andreas, Tobias W. Giessen 2024-05-03T03:10:17Z 置信度 0.70
• Design of a sequestration-based network with tunable pulsing dynamics
  Abstract Incoherent feedforward networks exhibit the ability to generate temporal pulse behavior. However, exerting control over specific dynamic properties, such as amplitude and rise time, poses a challenge and is intricately tied to the network’s implementa…
  crossref Eiji Nakamura, Christian Cuba Samaniego, Franco Blanchini, Giulia Giordano 等 2024-03-24T23:46:58Z 置信度 0.70
• Genome Editing, Transcriptional Regulation, and Forward Genetic Screening Using CRISPR-Cas12a Systems in Yarrowia lipolytica
  crossref Adithya Ramesh, Sangcheon Lee, Ian Wheeldon 2024-03-11T22:02:42Z 置信度 0.70
• Analysing the Contribution of Research Centres in Synthetic Biology to Transformative Innovation. Insights from Australia and the UK
  crossref Artem Anyshchenko, Rachel Parker 2024-08-07T11:23:05Z 置信度 0.70
• Biologie de synthèse en relation avec la conservation de la nature: document d’information
  crossref 2024-03-13T20:42:49Z 置信度 0.70
• Open Problems in Synthetic Multicellularity
  Multicellularity is one of the major evolutionary transitions, and its rise provided the ingredients for the emergence of a biosphere inhabited by complex organisms. Over the last decades, the potential for bioengineering multicellular systems has been instrum…
  crossref Ricard Sole, Nuria Conde, Jordi Pla Mauri, Jordi Garcia Ojalvo 等 2024-07-30T11:00:41Z 置信度 0.70
• Repurposing Drugs for Senotherapeutic Effect: Potential Senomorphic Effects of Female Synthetic Hormones
  Repurposing previously approved drugs may fast track the route to clinic for potential senotherapeutics and improves the inefficiency of the clinical drug development pipeline. We carried out a repurposing screen of 240 clinically approved molecules in human p…
  crossref Laura Rosemary Bramwell, Ryan Frankum, Lorna Harries 2024-01-30T03:09:42Z 置信度 0.70
• Development of Modular Expression and Genome Editing Across Phylogenetically Distinct Diazotrophs
  Diazotrophic bacteria can reduce atmospheric nitrogen into ammonia enabling bioavailability of the essential element. Many diazotrophs associate closely with plant roots increasing nitrogen availability, acting as plant growth promoters. These associations hav…
  crossref Shawn Kulakowski, Alex Rivier, Rita Kuo, Sonya Mengel 等 2024-05-23T01:30:12Z 置信度 0.70
• A dual-inducible control system for multistep biosynthetic pathways
  ABSTRACT Background The successful production of industrially relevant natural products hinges on two key factors: the cultivation of robust microbial chassis capable of synthesizing the desired compounds, and the availability of reliable genetic tools for exp…
  crossref Andrés Felipe Carrillo Rincón, Alexandra J. Cabral, Andras Gyorgy, Natalie G. Farny 2024-06-13T01:10:18Z 置信度 0.70
• In Vivo Tracking Deciphers the Traversal of Ebola Virus across the Blood-Testis Barrier.
  Ebola virus (EBOV) can persist in semen to mediate sexual transmission and drive epidemic resurgence. However, the mechanism by which EBOV breaches the blood-testis barrier (BTB) to invade the male reproductive system remains poorly understood. Here, we develo…
  pubmed Guo Z, Gao J, Li W, Zhang X 等 2026 Aug 19 置信度 0.82
• Identification and functional characterization of UDP-glycosyltransferases catalyzing the glycosylation of oleoside 11-methyl ester in Olea europaea.
  Two UDP-glycosyltransferases from Olea europaea were identified and characterized. Both catalyze the glycosylation of oleoside 11-methyl ester to form 7-&#x3b2;-1-D-glucopyranosyl 11-methyl oleoside, a putative intermediate in the oleuropein biosynthetic pathw…
  pubmed Jiang L, Bai P, Tang J, Zhuang Y 等 2026 置信度 0.82
• Complete genome sequence of Streptomyces diastaticus strain GN02 and analysis of its biosynthetic gene clusters.
  We report the first complete genome sequence of Streptomyces diastaticus strain GN02, isolated from a patient with actinomycetoma. The genome comprises a 6.8 Mb linear chromosome with a GC content of 73.5%. Genome analysis identified 23 biosynthetic gene clust…
  pubmed González-Nava J, Elenes-Zazueta HJ, Marcos-Viquez J 2026 Aug 19 置信度 0.82
• Decoupling virulence from growth: a synthetic α-helical peptide suppresses Salmonella Typhimurium SPI-1 at sub-inhibitory concentrations.
  Cationic antimicrobial peptides (CAMPs) can alter bacterial physiology at concentrations below those required to inhibit growth, including modulation of virulence gene expression. In Salmonella Typhimurium, polymyxin B activates the PhoPQ envelope stress respo…
  pubmed Tandon N, Storrud K, Granit NF, Gabrielian A 等 2026 Aug 19 置信度 0.82
• Virtual screening of GPR37L1 small-molecule modulator for neuropathic pain.
  Accumulating evidence indicates that glial cells play a critical role in the initiation, maintenance, and resolution of neuropathic pain. However, there is lack of glia-specific molecular targets for pain management. We recently identified the G protein-couple…
  pubmed Chandra S, Xu J, Bang S, Guo R 等 2026 Sep 1 置信度 0.82
• Synthesis of a guanylylated peptide derived from norovirus VPg as a molecular tool for studying norovirus replication.
  Norovirus is a leading cause of global acute gastroenteritis, yet the mechanisms underlying its replication remain incompletely understood. As a positive-sense single-stranded RNA (+ ssRNA) virus, norovirus utilizes a nucleotidylated viral protein (VPg) as a p…
  pubmed van Puffelen B, Neves LX, Steneker R, Meeuwenoord NJ 等 2026 Aug 10 置信度 0.82
• Systematic discovery of novel ribozymes with gene silencing properties from global deep-sea RNA viromes.
  Deep-sea ecosystems harbor extraordinary viral diversity, yet their potential as reservoirs of catalytic RNAs remains unexplored. Here, we systematically analyzed RNA viromes from 291 globally distributed deep-sea sediment samples, spanning seven distinct ecos…
  pubmed Zhang Y, Zhang X 2026 置信度 0.82
• Programmable 3D Microfluidics Reveals Motility-Driven Antibiotic Resistance Evolution in Gradients.
  Antibiotic resistance has become a serious threat to global health. It frequently emerges in real-world environments such as biofilms, where antibiotic gradients impose selective pressures that drive bacterial adaptation. However, the mechanisms underlying res…
  pubmed Li X, Yin J, Song Y, Glidle A 等 2026 Aug 18 置信度 0.82
• Viability of Tumor Cells in Bone Dust: Implications for Oncologic Skull Base Surgery.
  Head and neck tumors with skull base involvement may require drilling of tumor infiltrated bone. We hypothesize that bone dust generated during this process contains viable tumor cells that may seed the surgical field.
  pubmed Bridgham K, Samarah H, De Ravin E, Kenny H 等 2026 Aug 18 置信度 0.82
• Micro/Nanomotors and Synthetic Polymers: Pioneering New Approaches for Antimicrobial Therapy.
  Antibiotic-resistant bacteria that cause diseases are one of the greatest threats facing people's lives around the globe because of the abuse of antibiotics. Due to increasing resistance, antibiotics are becoming less effective. Therefore, there is an immediat…
  pubmed AlMatar M, Albarri O, Abdelmalek IB 2026 置信度 0.82
• Modulating endergonic triplet photosensitization for cycloadditions between bicyclo[1.1.0]butanes and alkenes.
  While energy transfer photocatalysis has recently been used in the synthesis of multisubstituted polycyclic alkanes as benzene bioisosteres, the use of highly reactive noble-metal and organo-photocatalysts often leads to rapid generation of diradical intermedi…
  pubmed Tang WY, Guo J, Nie S, Yang J 等 2026 Aug 18 置信度 0.82
• Nitrene generation and transfer for unnatural biosynthesis in living cells.
  Synthetic biology has enabled the production of natural and unnatural products from inexpensive sustainable feedstocks. Yet, the scope of available products has been limited largely to compounds accessible from nature's chemical reactions. Evolved enzymes can …
  pubmed Donnell I, Quest A, Tang J, Zhang M 等 2026 Aug 18 置信度 0.82
• The lncRNA PHAROH augments MYC mRNA levels in insulin-producing cells by counteracting TIA1-induced MYC silencing.
  Type 1 and type 2 diabetes are characterized by beta cell dysfunction and insulin deficiency, and the appropriate turnover of MYC expression appears to control the beta-cell fate. Therefore, it is important to better understand the mechanism that controls MYC …
  pubmed Zhao T, Welsh N 2026 Aug 18 置信度 0.82
• Material agency: operationalizing the living/nonliving interface in engineered materials.
  The label 'engineered living materials' groups devitalized mycelium composites with metabolically active biosensors, applying shared metrics to systems with fundamentally different failure modes, safety profiles, and engineering requirements. This forum propos…
  pubmed Belluati A 2026 Aug 18 置信度 0.82
• Alcohol oxidase-free methanol assimilation boosts carbon efficiency and product yield in industrial yeasts.
  Methanol is an attractive single-carbon feedstock for scalable bioprocesses that avoids the consumption of agricultural products. Native yeast methylotrophy relies on alcohol oxidase (Aox), which dissipates reducing power and limits carbon conversion efficienc…
  pubmed Moritz C, Enzinger V, Kowarz V, Severinsen MM 等 2026 Nov 25 置信度 0.82
• A diversified consortium of engineered biosensors enables multi-target quantification.
  Whole-cell biosensors (WCBs) offer rapid, cost-effective monitoring of environmental contamination. Efforts to optimize detection of isolated target analytes under laboratory conditions have achieved vastly improved performance and set the stage for WCB deploy…
  pubmed Chiang AJ, Csicsery N, O'Laughlin R, Baumgart L 等 2026 置信度 0.82
• Synthetically engineered probiotic suppresses colorectal cancer via inhibition of Wnt/β-catenin signaling.
  Colorectal cancer (CRC) is one of the most prevalent malignancies globally. Recent breakthrough of synthetic biology stimulates the utilization of engineered bacteria for cancer diagnosis and treatment. We perform a comprehensive fecal metabolomic analysis in …
  pubmed Sun Y, Zhao Y, Han K, Hu W 等 2026 Aug 18 置信度 0.82
• Impaired Cardiac Myosin Super-Relaxation as an Energy-Dissipating Process in Human Heart Failure with Reduced Ejection Fraction.
  Systolic heart failure is increasingly recognized as a disease of impaired cardiac energy metabolism. Here, the authors show that cardiac myosin super-relaxation (an energy-conserving myosin state) is destabilized in failing human myocardium. Importantly, this…
  pubmed Ma W, Chaami C, Melhedegaard EG, Lewis CTA 等 2026 Aug 18 置信度 0.82
• OsCYP51H9 integrates brassinosteroid biosynthesis and nitrogen sensing to enhance grain development and nitrogen utilization in rice.
  Nitrogen use efficiency (NUE) and grain development are pivotal for rice yield improvement, particularly under low-nitrogen (LN) conditions. Cytochrome P450 CYP51 family members are conserved obtusifoliol 14&#x3b1;-demethylases essential for phytosterol and br…
  pubmed Jiao Z, Li J, Xu W, Yin L 等 2026 Aug 7 置信度 0.82
• Engineering bubble structures as Cas12a activators for highly sensitive monitoring of WRN helicase function.
  The Werner syndrome helicase (WRN) is a critical synthetic lethal target in microsatellite instability cancers, essential for resolving complex genomic structures like replication bubbles and R-loops. However, strategies to simultaneously discriminate WRN acti…
  pubmed Ke J, Zhang H, Chen S, Ma M 等 2026 Aug 13 置信度 0.82
• High-Throughput Screening of L-Lactic Acid-Hyperproducing Bacillus coagulans Mutants Using an Automated Droplet Microfluidic Platform.
  Industrial biomanufacturing relies on microorganisms to efficiently synthesize target products under engineered conditions. However, wild-type strains often lack the capability to do so due to their native metabolic networks. Therefore, the rapid and accurate …
  pubmed Da X, Li S, Wang Q, Luo X 等 2026 置信度 0.82
• Genome Editing in Primary Mammalian Cells via Electroporation of Editor RNA.
  CRISPR editors including nucleases, base editors, and prime editors can efficiently correct disease-causing genetic variants or disrupt target genes. Editing outcomes are commonly evaluated in cultured primary cells, patient-derived cells, or engineered cell l…
  pubmed Viskadourou M, Workman JN, Burke EV, Eckley DM 等 2026 Jul 31 置信度 0.82
• Optimized Yeast Surface Display Workflow for Directed Evolution of Proteases.
  Directed evolution mimics the natural evolutionary process in a fast, controlled laboratory environment to evolve proteins with desirable functions or traits. Screening a large pool of mutant protein-coding genes allows functional selection of desired variants…
  pubmed Lim Suan MB Jr, Quadri Z, Jorapur SR, Dingal PCDP 2026 Aug 4 置信度 0.82
• Intermolecular Noncovalent Locks Enable Red-Shifted Emission, Modulated Reactive Oxygen Species Generation Pathway, and Shuttle-Like Nanoassembly for Phototheranostics.
  Developing phototheranostic agents that combine high reactive oxygen species (ROS) generation, favorable fluorescence wavelength and intensity, and prolonged tumor retention remains a major challenge. Although molecular engineering enables precise tuning of mo…
  pubmed Gong Z, Kang G, Rong X, Li S 等 2026 Aug 18 置信度 0.82
• Photodictated Programmed Orthogonal DNA Microdroplets Enable Molecular Communication between Transient Self-Sorting Membraneless Artificial Cells.
  Bottom-up construction of artificial cells that exhibit dynamic molecular communication, spatial self-sorting, and dissipative signaling remains a central challenge in synthetic biology. In particular, achieving programmable interactions between orthogonal dro…
  pubmed Yuan F, Zhou J, Kuang Z, Zhang M 等 2026 Aug 18 置信度 0.82
• Enhancing the Membrane Destabilization Capacity of DNA-Surfactant Conjugates for Improved Cytosolic Delivery of Nucleic Acids.
  Enhancing the endosomal escape of nucleic acids remains a critical bottleneck in improving their therapeutic efficacy. Inspired by advancements in lipid nanoparticles, we describe a chemical approach to deliver multi-tailed DNA-surfactant conjugates (DSCs) int…
  pubmed Gorecki J, Fuente IF, Corrigan PM, Pal S 等 2026 Aug 18 置信度 0.82
• Fluorogenic RNA Aptamer-Based Activity Quantification of T7 RNA Polymerase.
  T7 RNA polymerase (T7 RNAP) is a central molecular biology tool that is broadly used for biomedical research and the RNA therapeutic industry. T7 RNAP and its engineered variants provide valuable tools in synthetic biology and gene expression regulation. T7 RN…
  pubmed Mimouni K, Qiu W, Zhou H 2026 Aug 18 置信度 0.82
• Spatially Encoded Protocell Network for Non-Cascaded Parallel Biocomputation.
  Biological systems inspire computing paradigms by autonomously regulating material and information flows through molecular interactions. While biomolecules such as enzymes and DNA have been harnessed for biocomputation, implementing complex logic operations re…
  pubmed Wu S, Tian L 2026 Aug 18 置信度 0.82
• Deep Learning-Driven Discovery and Engineering of an Efficient PETase for Depolymerization and Detoxification of PET Microplastics Under Physiological Conditions.
  Microplastics (MPs) accumulation in ecosystem and human organs poses urgent environmental and health risks, yet few enzymes efficiently degrade polyethylene terephthalate (PET) under physiological conditions. We leveraged deep learning to mine unexplored seque…
  pubmed Wang Y, He S, Chang Y, Mao S 等 2026 Aug 18 置信度 0.82
• Effects of Processing Variables on the Quality Characteristics of Wheat Gluten/Morchella esculenta Mycelium-Based High-Moisture Extrudate.
  High-moisture extrusion is an important technology for producing fibrous plant-based meat analogs, yet the relative contributions of different processing variables to quality formation remain unclear. In this study, wheat gluten and Morchella esculenta myceliu…
  pubmed Su X, Hu X, Li P, Zhou K 等 2026 Aug 置信度 0.82
• Vitamin B(1)-catalyzed green synthesis and antiplasmodial evaluation of 2-amino-7-hydroxy-4-aryl-4H-chromene-3-carbonitrile derivatives: computational insights into putative PfNDH2 targeting.
  A green and sustainable synthetic protocol was developed for the preparation of a previously unreported series of 2-amino-7-hydroxy-4-aryl-4 H -chromene-3-carbonitrile derivatives (PPA1-PPA5) using vitamin B 1 (thiamine hydrochloride) as an inexpensive and env…
  pubmed Patil P, Bagul A, Kumar M, Tufail A 等 2026 Aug 17 置信度 0.82
• Vγ9Vδ2 T cells in tuberculosis: protective immunity and translational perspectives.
  V&#x3b3;9V&#x3b4;2 T cells constitute the predominant human circulating &#x3b3;&#x3b4; T cell subset and serve as key mediators of anti-mycobacterial immunity through major histocompatibility complex (MHC)-unrestricted phosphoantigen recognition and rapid effe…
  pubmed Shi Z, Ding Y, Jing X, Wang F 等 2026 置信度 0.82
• Comprehensive Chemical and Biological Assessment of Orobanche racemosa Extracts Using Chromatographic, In Vitro, In Silico, and Cell-Based Techniques.
  The growing interest in natural product research as a safer and sustainable alternative to synthetic drugs has triggered this study, which evaluates the chemical profile and biological activity of Orobanche racemosa extracts. In the current study, extraction w…
  pubmed Nilofar N, Saka E, Cetiz MV, Rodrigues MJ 等 2026 Sep 置信度 0.82
• SBOL converter: enabling backward compatibility for biological designs.
  The Synthetic Biology Open Language (SBOL) is a community-driven and machine-readable standard for creating and sharing biological designs. SBOL has evolved over the years, resulting in three major versions, each introducing new features. Although SBOL3 is the…
  pubmed Ünal M, Myers CJ, Medeni IT, Beal J 等 2026 置信度 0.82
• Closing the Translational Gap: Closed-Loop AI Discovery Frameworks for Experimental Validation and Clinical Implementation in Cancer Therapeutics.
  The development of novel cancer therapeutics is a protracted, costly endeavor with high attrition rates, largely attributed to tumor heterogeneity and acquired resistance. Artificial intelligence (AI) is emerging as a powerful technology to enhance the drug di…
  pubmed Ören Varol T, Varol M 2026 Aug 置信度 0.82
• Living circuit boards built by printing bacterial transistors.
  The multicellular forms and functions seen in biology are controlled by cellular communication and collective computation. Reprogramming natural systems is difficult because they comprise many signaling molecules connecting a web of regulatory networks within …
  pubmed Doosthosseini H, Chen H, Voigt CA 2026 Aug 17 置信度 0.82
• Author Correction: Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.
  pubmed Genovese G, Carugo A, Tepper J, Robinson FS 等 2026 Aug 17 置信度 0.82
• A protein-foldamer supramolecular synthon for self-assembled hybrid architectures.
  Constructing artificial assemblies that combine proteins and synthetic ligands has been hampered by the lack of protein-ligand interfaces that are sufficiently large and organized to enable precise structural control. Here ribosome display selection is used to…
  pubmed Sigl J, Morozov V, Wang L, Sachs J 等 2026 Aug 17 置信度 0.82
• Corisin induces proteostasis stress to drive epithelial injury and pulmonary fibrosis.
  Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disease lacking clarity on the mechanisms linking epithelial injury to fibrotic remodeling. Here, we identify the microbiota-derived corisin as a potent, multifaceted driver of epithelial injury and p…
  pubmed Fujimoto H, Yasuma T, D'Alessandro-Gabazza CN, Toda M 等 2026 Aug 1 置信度 0.82
• Harnessing macrophage signaling pathways and scalable engineering for next-generation immunotherapies.
  Macrophages have emerged as promising candidates for cell-based immunotherapies due to their intrinsic plasticity, tissue-infiltrating capabilities, and central roles in orchestrating immune responses. Their phenotypic and functional diversity within tissues a…
  pubmed Paasch D, Haake K, Kan C, Ulpiano C 等 2026 Aug 18 置信度 0.82
• Ingesting Twenty Grams of Protein, Regardless of Quality, was Insufficient to Improve Protein Synthesis Rates in Adult Males.
  Sufficient high-quality protein intake is required to prevent sarcopenia in older adults. Plant-based proteins have been reported to have lower anabolic properties when compared with animal-based proteins. Whether the lower quality of plant-based protein can b…
  pubmed Kuin LM, Hermans WJ, Boot N, Fuchs CJ 等 2026 Aug 17 置信度 0.82
• Rabeprazole exhibits broad-spectrum fusion inhibition against Nipah pseudovirus and authentic HCoV-OC43 and RSV.
  Rabeprazole was previously defined as a small-molecule fusion inhibitor that binds the conserved hydrophobic HR1 groove of the SARS-CoV-2 spike and blocks six-helix bundle assembly. Here, we expand its antiviral spectrum and demonstrate potent activity against…
  pubmed Shen Y, Wang B, Li J, Liang Z 等 2026 Aug 14 置信度 0.82
• Distinct immunomodulatory effects of synthetic progestins compared with natural progesterone in human immune cells.
  Progesterone exerts important immunomodulatory functions, yet the immune effects of structurally diverse synthetic progestins remain incompletely defined. Given their variable receptor-binding profiles and links to altered inflammatory outcomes, we examined ho…
  pubmed Patel AJ, Karandikar AN, Miron-Ocampo A, Karandikar NJ 等 2026 Aug 4 置信度 0.82
• The limitations of non-mechanistic methods for characterizing pathogen-pathogen interactions: A simulation study.
  Pathogen-pathogen interactions occur when infection with one pathogen influences one's chance of infection or disease due to another. Increasingly, evidence suggests that interactions are a common feature of infectious disease epidemiology. However, due to bot…
  pubmed Kramer SC, Pirikahu S, Kussmaul C, Opatowski L 等 2026 置信度 0.82
• Which Bonding Protocol Provides the Most Durable Zirconia Adhesion after In Vitro Artificial Aging: A Systematic Review.
  The aim of this study is to systematically review the scientific publications on animal model studies investigating the histological analysis of hydroxyapatite (HA) and collagen from biowaste as bone substitutes for bone regeneration.
  pubmed Ariesanti Y, Tjandrawinata R, Poedjiastoeti W, Priosoeryanto BP 等 2025 Dec 1 置信度 0.82
• Olikomycin A Disrupts Gram-Positive Bacterial Membranes Through Calcium-Dependent Binding to Phosphatidylglycerol.
  Calcium-dependent antibiotics (CDAs) represent an important class of antimicrobial agents active against Gram-positive pathogens. Olikomycin A, produced by Streptomyces ghanaensis &#x394;wblA, displays potent activity against multidrug-resistant bacteria; howe…
  pubmed Munz L, Makshakova O, Marchi S, Römer W 等 2026 Aug 置信度 0.82
• Fluorescent-Activating Proteins Manipulate Self-Assembly Peptides Trafficking and Intracellular Distribution.
  Peptide-based probes and therapeutics are often hindered by lysosomal degradation and stochastic trafficking, which limit their ability to engage specific organelles with precision. Here, we report a self-assembled peptide system incorporating malachite green …
  pubmed Zhao C, Li X, Liu R, Guo R 等 2026 Aug 17 置信度 0.82
• Asymmetric Evolution of Antennal Cell Types Underlies a Derived Ammonia-Sensing Logic for Ecological Adaptation in Bactrocera dorsalis.
  Olfaction is crucial for insects adapting to agroecosystems and becoming significant crop pests, but how the antenna, a multicellular olfactory organ, is systematically organized at the cellular and molecular levels is not well understood. This study focuses o…
  pubmed Liu W, Zhang S, Zhang J, Tian Z 等 2026 Aug 17 置信度 0.82
• Small Extracellular Vesicle-Derived Nidogen 1 Promotes HCC Carcinogenesis via Transglutaminase 3-Mediated YAP/TAZ Signalling.
  Tumour-derived small extracellular vesicles (sEV) are increasingly recognized as key mediators of cancer progression and metastasis by facilitating intercellular communication. In this study, we identify nidogen 1 (NID1), a basement membrane glycoprotein, as s…
  pubmed Yeung CLS, Cui L, Wang J, Chan CP 等 2026 Aug 置信度 0.82
• Metabolic Engineering of Komagataella Phaffii for de Novo Synthesis of Retinol From Methanol.
  Retinol, a derivative of vitamin A with potent antioxidant and therapeutic properties, is in high market demand. In response to the low productivity of conventional methods, metabolic engineering has been explored for microbial retinol production. However, sys…
  pubmed Wu Y, Liu C, Liang S, Jiang Y 等 2026 置信度 0.82
• Immunological Evaluation of mRNA-LNP Vaccines Targeting Conserved S2 and NSP3 Domains of SARS-CoV-2.
  The evolution of SARS-CoV-2 necessitates next-generation vaccine strategies targeting conserved viral elements to ensure broad and durable protection. In this study, we designed and evaluated novel mRNA-based vaccines encoding conserved domains of SARS-CoV-2, …
  pubmed Begum F, Mallik MH, Ghora S, Ray U 2026 Aug 置信度 0.82
• Genome-wide integrative dissection of genetic basis of fiber color and whiteness regulation in upland cotton (Gossypium hirsutum).
  Naturally colored cotton has gained renewed interest due to increasing environmental concerns over synthetic dyes. The genetic regulatory characteristics of fiber color are discovered by two perspectives in this study.
  pubmed Khalid S, Wang Z, Mahmood T, Geng X 等 2026 Jul 27 置信度 0.82
• Occurrence and risk assessment of antibiotic residues in Mediterranean olive grove soils with different management: an EU-wide pilot study.
  Synthetic fertilizers used in agriculture are a major source of soil pollution. Sustainable soil management is crucial in maintaining long-term soil health and functionality. Implementing sustainable farming systems, such as organic farming, replaces synthetic…
  pubmed Rascón AJ, Fernández-García A, Moreno-Gónzalez D, Gilbert-López B 等 2026 Aug 16 置信度 0.82
• Trans-interface coupling in the tetrameric enzyme underlies allosteric control in Escherichia coli biosynthetic threonine deaminase.
  Allosteric regulation in biosynthetic L-threonine deaminase (BTD) has long been attributed to effector-induced conformational changes. Here, we identify a trans-interface coupling mechanism that regulates the active site architecture of EcIlvA, the BTD homolog…
  pubmed Khodi S, Yekeen AA, Liu H, Chen Q 2026 Dec 置信度 0.82
• Unlocking raw-corncob consolidated bioprocessing for malic acid production by DyP-enabled lignin deconstruction in Myceliophthora thermophila.
  l-Malic acid is an important C4 platform chemical, but its direct production from raw lignocellulosic biomass by consolidated bioprocessing (CBP) remains constrained by biomass recalcitrance. Here, we developed an integrated lignin-side and sugar-side engineer…
  pubmed Zhang Y, Han L, Liu J, Liu D 等 2027 Mar 置信度 0.82
• Automated synthetic cell-based screening for designed proteins with emergent functions.
  Designing minimal biological systems with emergent functions such as spatiotemporal self-organization is a central goal of bottom-up synthetic biology. While computational optimization and design show promise in accelerating functional protein engineering thro…
  pubmed Al Nahas K, Frohn BP, Šakanović A, Siedler F 等 2026 置信度 0.82
• Retraction notice to "Targeting enteroviral 2A protease by a 16-mer synthetic peptide: Inhibition of 2APro-Induced apoptosis in a stable Tet-on HeLa cell line" [Virology 399 (2010) 39-45].
  pubmed Maghsoudi N, Tafreshi NK, Khodagholi F, Zakeri Z 等 2026 Aug 15 置信度 0.82
• DNA damage response genes in lung cancer: Diagnostic, prognostic, and therapeutic implications - A narrative review.
  Lung cancer management remains constrained by a fragmented understanding of the clinical implications of DNA Damage Response (DDR) pathways. This review synthesizes current evidence to position DDR variants as potential prognostic, predictive, and therapeutic …
  pubmed Durán-Toribio AK, Jiménez-Díaz IF, Caballé-Pérez E, Lucio-Lozada J 等 2026 Aug 15 置信度 0.82
• Structural insights into native intact Mycobacterium abscessus by conventional and ultrahigh-field solid-state NMR at 1.2 GHz.
  We present an ultrahigh-field magic-angle spinning (MAS) solid-state NMR (ssNMR) study to characterize intact nontuberculous mycobacteria (NTM). Hydrated and dried whole-cell Mycobacterium abscessus samples were investigated by combining conventional high-fiel…
  pubmed Byeon CH, Wang YH, Tunc A, Franks WT 等 2026 Aug 11 置信度 0.82
• In vitro selection of VNAR antibodies using bioinformatics-based library design and cDNA display.
  Variable domains of new antigen receptors (VNARs) derived from shark immunoglobulin new antigen receptors (IgNARs) have gained attention as promising single-domain antibody modalities owing to their compact structures, structural stability, and unique binding …
  pubmed Anzai H, Terai T, Mitsuyama S, Matsunaga R 等 2026 Sep 置信度 0.82
• Diagnosing soil bioremediation failure: evidence-weighted pathways from mechanism to field closure.
  Soil bioremediation is often presented as a sustainable alternative to physicochemical remediation, yet its field performance remains less predictable than laboratory and microcosm evidence suggests. This critical review argues that the central problem is not …
  pubmed Mrozik A, Piotrowska-Seget Z, Cycoń M 2026 置信度 0.82
• Comparative pan-genomics reveals pervasive lineage-specific innovations and improves cross-species synteny inference in cereals.
  pubmed Dorjee T, Wang Y, Sun S, Wei C 等 2026 Aug 14 置信度 0.82
• Bottom-up reconstruction of synthetic pyrenoids provides insights into the mechanisms and evolution of carbon concentration by EPYC1 proteins.
  Membraneless organelles play essential roles in many cellular processes. In various photosynthetic organisms, they are a crucial part of CO 2 /carbon-concentrating mechanisms (CCMs) that increase photosynthetic productivity. One example is the pyrenoid in Chla…
  pubmed Küffner AM, Pommerenke B, Kley L, Ng JZY 等 2026 置信度 0.82
• Polyamines buffer labile iron to suppress ferroptosis.
  Polyamines are essential and evolutionarily conserved metabolites present at millimolar concentrations in mammalian cells. Cells tightly regulate polyamine homeostasis through complex feedback mechanisms, yet the precise role necessitating this regulation rema…
  pubmed Sharma P, Keys HR, Mansell RP, Stark J 等 2026 Aug 14 置信度 0.82
• Phenotype-driven screening of semi-synthetic terpene analogs identifies TRX-41 as a lead compound active in chemotherapy-resistant breast cancer organoids.
  Natural products remain an important source of anticancer agents, yet identifying pharmacological vulnerabilities in chemotherapy-refractory tumors remains a major challenge. Natural terpenes (NT) represent one of the most structurally diverse classes of bioac…
  pubmed Mo A, Dos Santos E Silva G, Dos Reis DB, Santana WJ 等 2026 Aug 14 置信度 0.82
• Recent advances in the chemical synthesis of Glycosaminoglycans.
  Glycosaminoglycans (GAGs) are complex carbohydrates ubiquitously expressed on cell surfaces and within the extracellular matrix, where they regulate essential biological processes through sequence- and sulfation-dependent interactions. Major GAG classes, inclu…
  pubmed Dumalaog JS, Hung SC 2026 Aug 14 置信度 0.82
• Conservation and divergence within the Arabidopsis TPL/TPR corepressor family.
  The TOPLESS (TPL) and TOPLESS-RELATED (TPR1-TPR4) corepressors, collectively the Arabidopsis TPL/TPR family, are recruited by client proteins to regulate nearly every major plant regulatory program. Here, we dissect the conservation and divergence between para…
  pubmed Downing BLR, Pattichis M, Vaistij FE, Farawila M 等 2026 Aug 14 置信度 0.82
• Distinct postnatal trajectories of mouse dendritic epidermal T cells and Langerhans cells independent of microbiota.
  The mouse epidermis harbors two key resident immune populations-dendritic epidermal T cells (DETCs), a subset of invariant &#x3b3;&#x3b4; T cells, and Langerhans cells (LCs), specialized tissue-resident macrophages-both of which play critical roles in immune s…
  pubmed Obwegs D, Oschwald A, Koetter LM, Crisand C 等 2026 Aug 14 置信度 0.82
• Vesicle Nucleation Peptide Fusion Induced Extracellular Vesicles Are Distinct From Escherichia coli Outer Membrane Vesicles, and Provide an Enhanced Platform for Protein Production and Purification.
  Bacterial outer membrane vesicles (OMVs) are nano-sized, spherical structures released by Gram-negative bacteria that play diverse roles in bacterial physiology, including communication, nutrient acquisition and host interactions. These vesicles bud from the b…
  pubmed Streather BR, Eastwood TA, Baker K, Liang M 等 2026 Aug 置信度 0.82
• Ingestible Hydrogel-Encapsulated Optogenetic Yeast Controlled by Wearable Electronics Enables Programmable IL-10 Delivery for Inflammatory Bowel Disease Therapy.
  Engineered yeast-living drugs offer significant potential for oral protein therapy but remain limited by poor intestinal retention and lack of precise spatiotemporal control over therapeutic delivery. Here, we developed an ingestible hydrogel-encapsulated opto…
  pubmed Zhang C, Li H, Jiang Y, Wang L 等 2026 Aug 14 置信度 0.82
• Immunization with PLGA-encapsulated recombinant staphylococcal enterotoxin C confers protection against intramammary Staphylococcus aureus challenge in a murine mastitis model.
  Mastitis caused by Staphylococcus aureus remains a significant challenge to control due to increasing antimicrobial resistance and the limited efficacy of existing vaccines. Staphylococcal enterotoxin C (SEC) is a critical virulence factor and a highly immunog…
  pubmed Deepak D, Prasanna P, Vaidya R, Ali SA 等 2026 Aug 14 置信度 0.82
• Environmental filtering shapes biosynthetic potential and resistome of antarctic microbiomes.
  Environmental filtering is a major driver of microbial community assembly in Antarctic ecosystems, yet its influence on biosynthetic potential and antimicrobial resistance remains poorly understood. Here, we analyzed 319 medium- to high-quality metagenome-asse…
  pubmed Medeiros WB, Hidalgo-Martinez KJ, Penna DDPS, Oliveira VM 2026 Aug 14 置信度 0.82