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• Adaptive Cellular Fault-Tolerance: A Bio-OS Framework for Tissue Regeneration using Interconnected Genetic Locking (IGL) and Distributed Somatic Intelligence
  Biological systems, specifically mammalian skeletal muscle tissues, are constrained by the Nucleocytoplasmic Ratio, wherein a single nucleus can govern only a finite cytoplasmic volume, leading to irreversible necrosis under critical trauma load. This paper in…
  datacite Singh, Priyanshu 2026 置信度 0.66 Bio-OSInterconnected Genetic LockingIGL FrameworkTissue RegenerationHexagonal Bio-Topology
• Adaptive Cellular Fault-Tolerance: A Bio-OS Framework for Tissue Regeneration using Interconnected Genetic Locking (IGL) and Distributed Somatic Intelligence
  Biological systems, specifically mammalian skeletal muscle tissues, are constrained by the Nucleocytoplasmic Ratio, wherein a single nucleus can govern only a finite cytoplasmic volume, leading to irreversible necrosis under critical trauma load. This paper in…
  datacite Singh, Priyanshu 2026 置信度 0.66 Bio-OSInterconnected Genetic LockingIGL FrameworkTissue RegenerationHexagonal Bio-Topology
• In Silico Design and Computational Validation of a Tri-Modular Genetic Circuit for Autonomous Detection and Bioremediation of Hexavalent Chromium in Closed-System Microcosms
  Hexavalent chromium [Cr(VI)], a Group 1 IARC carcinogen, reaches up to 3.54 mg/L in Bangladesh’s BurigangaRiver (35-fold above the US EPA limit) due to unregulated tannery effluent. Existing remediation is passive, lackingreal-time sensing, dose-responsive tre…
  datacite Shaad, Zubayer Hasan 2026 置信度 0.66 Genetic CircuitHexavalent Chromium (Cr(VI))Computational BiologySynthetic BiologyEscherichia coli
• In Silico Design and Computational Validation of a Tri-Modular Genetic Circuit for Autonomous Detection and Bioremediation of Hexavalent Chromium in Closed-System Microcosms
  Hexavalent chromium [Cr(VI)], a Group 1 IARC carcinogen, reaches up to 3.54 mg/L in Bangladesh’s BurigangaRiver (35-fold above the US EPA limit) due to unregulated tannery effluent. Existing remediation is passive, lackingreal-time sensing, dose-responsive tre…
  datacite Shaad, Zubayer Hasan 2026 置信度 0.66 Genetic CircuitHexavalent Chromium (Cr(VI))Computational BiologySynthetic BiologyEscherichia coli
• RENASCENT-Q Theory v.37: Consciousness as Negentropic Retrocausal Geometry – A Fifth Fundamental Force Unifying the Standard Model, Riemann Spectrum, Cosmology, and Quantum Biology
  We present RENASCENT-Q Theory v.37, a geometric framework in which negentropic coherence emerges as a fifth fundamental force. The theory is anchored by the Federico Maya Eternity Theorem, which establishes that the dilatonic operator on a compact 12-dimension…
  datacite Federico Maya 2026 置信度 0.66 Riemann Hypothesis, curvature-dimension condition, optimal transport, negentropic coherence, lepton flavor violation, synthetic Ricci curvature, topological quantum processor, quantum biology, cosmological anomalies, displacement convexity
• RENASCENT-Q Theory v.35.1: Consciousness as Negentropic Retrocausal Geometry – A Fifth Fundamental Force Unifying the Standard Model, Riemann Spectrum, Cosmology, and Quantum Biology
  This is version 35.1 of RENASCENT-Q Theory, a geometric framework proposing that negentropic coherence acts as a fifth fundamental force. The theory is built on the Federico Maya Eternity Theorem, which links the essential self-adjointness of a 12-dimensional …
  datacite Federico Maya 2026 置信度 0.66 Riemann Hypothesis, curvature-dimension condition, optimal transport, negentropic coherence, lepton flavor violation, synthetic Ricci curvature, topological quantum processor, quantum biology, cosmological anomalies, displacement convexity
• RENASCENT-Q Theory v.45 (Extension): The Origin of the Resonant Negentropic Asymptotic Coherent Entangled with Quantum Field Fundamental Force
  RENASCENT-Q Theory v.45 (Extension) is built on two settled mathematical results: the dual-lock arithmetic-geometric proof of the Riemann Hypothesis (Federico Maya Eternity Theorem) and the Federico Maya Eternal Information Formula. The former establishes that…
  datacite Federico Maya 2026 置信度 0.66 Riemann Hypothesis, curvature-dimension condition, optimal transport, negentropic coherence, lepton flavor violation, synthetic Ricci curvature, topological quantum processor, quantum biology, cosmological anomalies, displacement convexityCrystallization HypothesisUniform Residual MeasureIrwin-Hall DistributionHolographic Boundary Jacobian
• RENASCENT-Q Theory: Negentropic Coherence as a Fifth Fundamental Force — Geometric Unification of the Standard Model, Riemann Spectrum, and Cosmology
  This work presents RENASCENT-Q Theory v.20.5, a geometric framework in which negentropic coherence is proposed as a fifth fundamental force. The theory is grounded in the Federico Maya Eternity Theorem, which links the self-adjointness of a 12-dimensional dila…
  datacite Federico Maya 2026 置信度 0.66 Riemann Hypothesis, curvature-dimension condition, optimal transport, negentropic coherence, lepton flavor violation, synthetic Ricci curvature, topological quantum processor, quantum biology, cosmological anomalies, displacement convexity
• Axiomatic Information Topology: The G.E.M.S. Matrix Engine and the Parameter-Free Origin of Particle Generations, Invariant Mass Scales, and Cosmic Acceleration
  I am looking to have this framework reviewed, feel free to contact me at adrianneillpivetta@hotmail.compython codes for everything in the framework are at the end of the document Volume I: The Physical Core and Geometric Field Alignment Part I: The Definitive …
  datacite Pivetta, Adrian Neill 2026 置信度 0.66 PhysicsMathematical physicsParticle physicsAtomic physicsNuclear physics
• Nonlinear Model Reduction of Complex Networks via Spectral Submanifolds
  Complex networked systems are prevalent in biology, engineering, and the social sciences, yet their high-dimensional, nonlinear dynamics pose major challenges for analysis and prediction. A mathematically rigorous route to simplification is to represent system…
  datacite Bhaskaran, Kaviya, Jain, Shobhit, Li, Mingwu 2026 置信度 0.66 Physics and Society (physics.soc-ph)Dynamical Systems (math.DS)Quantitative Methods (q-bio.QM)FOS: Physical sciencesFOS: Mathematics
• Viability Boundaries of Living Systems: A Phenomenological Theory (RU)
  What distinguishes a living system from a non-living one — not by a list of features, but by a criterion that can actually be computed? Theoretical biology answers this in roughly two ways. Replication-first accounts (the RNA world, the Joyce/NASA working defi…
  datacite Avdeev, Vasiliy 2026 置信度 0.66 theoretical biology; living systems; nonequilibrium thermodynamics; open dissipative systems; biological aging; origin of life; allometric scaling; structural entropy; system degradation; history-dependent processes; viability boundary; minimum viable structure; system integrity; repair mechanisms; lifespan modeling; finite lifetime theorem; complex systems; phenomenological theory; Rosen (M,R)-systems; Bauer principle
• Viability Boundaries of Living Systems: A Phenomenological Theory (RU)
  What distinguishes a living system from a non-living one — not by a list of features, but by a criterion that can actually be computed? Theoretical biology answers this in roughly two ways. Replication-first accounts (the RNA world, the Joyce/NASA working defi…
  datacite Avdeev, Vasiliy 2026 置信度 0.66 theoretical biology; living systems; nonequilibrium thermodynamics; open dissipative systems; biological aging; origin of life; allometric scaling; structural entropy; system degradation; history-dependent processes; viability boundary; minimum viable structure; system integrity; repair mechanisms; lifespan modeling; finite lifetime theorem; complex systems; phenomenological theory; Rosen (M,R)-systems; Bauer principle
• Evolutionary chemical learning in dimerization networks
  We present a framework for chemical learning based on Competitive Dimerization Networks (CDNs) - systems in which multiple molecular species, e.g., proteins, DNA oligomers, or RNA oligomers, reversibly bind to form dimers. We show numerically that these networ…
  datacite Tkachenko, Alexei V., Mognetti, Bortolo Matteo, Maslov, Sergei 2025 置信度 0.66 Statistical Mechanics (cond-mat.stat-mech)Disordered Systems and Neural Networks (cond-mat.dis-nn)Machine Learning (cs.LG)Adaptation and Self-Organizing Systems (nlin.AO)Data Analysis, Statistics and Probability (physics.data-an)
• From Engineering to Ontological Ground
  This paper provides a rigorous philosophical and conceptual analysis of the groundbreaking creation of "SpudCell" the first functional synthetic cell constructed from non-living chemical components, announced by Nathaniel Gaut's team on July 1, 2026. While the…
  datacite BELKHEIRI, Nadji 2026 置信度 0.66 Synthetic BiologySpudCellAbiogenesisBiological InformationPhilosophy of Biology
• From Engineering to Ontological Ground
  This paper provides a rigorous philosophical and conceptual analysis of the groundbreaking creation of "SpudCell" the first functional synthetic cell constructed from non-living chemical components, announced by Nathaniel Gaut's team on July 1, 2026. While the…
  datacite BELKHEIRI, Nadji 2026 置信度 0.66 Synthetic BiologySpudCellAbiogenesisBiological InformationPhilosophy of Biology
• Supplementary Data for: PURE makes PURE: reconstitution of the PURE cell-free system from self-synthesized proteins
  Changes in this version (v3): Updated Figure numbers. Abstract: Building a universal biochemical constructor, an autonomously self-replicating biochemical system, remains a challenge in synthetic biology. The PURE cell-free system is a suitable starting point …
  datacite Mottaghi, Seyed Saeed, Maerkl, Sebastian J. 2026 置信度 0.66
• Supplementary Data for: PURE makes PURE: reconstitution of the PURE cell-free system from self-synthesized proteins
  Changes in this version (v3): Updated Figure numbers. Abstract: Building a universal biochemical constructor, an autonomously self-replicating biochemical system, remains a challenge in synthetic biology. The PURE cell-free system is a suitable starting point …
  datacite Mottaghi, Seyed Saeed, Maerkl, Sebastian J. 2026 置信度 0.66
• Terminology for Industrial Biotechnology and Synthetic Biology
  crossref 2024-08-15T18:18:01Z 置信度 0.70
• Gene Synthesis – Enabling Technologies for Synthetic Biology
  crossref Michael Liss, Ralf Wagner 2011-05-20T17:49:31Z 置信度 0.70
• Synthetic Biology and Genetic Engineering: Parallels in Risk Assessment
  crossref Broder Breckling, Gunther Schmidt 2014-09-27T04:08:50Z 置信度 0.70
• Terminology for Industrial Biotechnology and Synthetic Biology
  crossref 2026-04-01T12:30:24Z 置信度 0.70
• Synthetic Biology with an All E. coli TXTL System: Quantitative Characterization of Regulatory Elements and Gene Circuits
  crossref Ryan Marshall, Vincent Noireaux 2018-05-12T09:12:31Z 置信度 0.70
• Synthetic Biology 2.0: The Dawn of a New Era
  crossref Huimin Zhao 2022-07-15T07:04:35Z 置信度 0.70
• SYNTHETIC BIOLOGY
  crossref 2014-10-27T14:59:40Z 置信度 0.70
• Terminology for Industrial Biotechnology and Synthetic Biology
  crossref 2026-05-29T12:30:26Z 置信度 0.70
• Modern Approaches in Synthetic Biology: Genome Editing, Quorum Sensing, and Microbiome Engineering
  crossref Taj Mohammad, Md. Imtaiyaz Hassan 2018-10-01T12:24:30Z 置信度 0.70
• In Search for a Legal Framework for Synthetic Biology
  crossref Gerd Winter 2016-04-15T05:10:13Z 置信度 0.70
• Terminology for Industrial Biotechnology and Synthetic Biology
  crossref 2025-05-16T12:30:43Z 置信度 0.70
• YouTube resources for synthetic biology education
  Abstract Online video resources have increasingly become a common way to effectively share scientific research ideas and engage viewers at many levels of interest or expertise. While synthetic biology is a comparatively young field, it has accumulated online v…
  crossref Aaron J Dy, Emily R Aurand, Douglas C Friedman 2019-09-05T12:54:14Z 置信度 0.70
• Synthetic Biology of Polyhydroxyalkanoates (PHA)
  crossref De-Chuan Meng, Guo-Qiang Chen 2017-05-31T05:47:14Z 置信度 0.70
• Design of synthetic biology for the detection of microorganisms
  crossref Dong-Dong Yang, Jake Flood, Rongming Liu, Susu He 2022-01-14T22:44:22Z 置信度 0.70
• Development of next-generation diagnostic tools using synthetic biology
  crossref Elizabeth J. Vojvoda, Logan R. Burrington, Javin P. Oza 2022-01-14T22:48:53Z 置信度 0.70
• Systems and synthetic biology approaches to cell division
  crossref Alireza Mashaghi, Cees Dekker 2014-01-29T10:38:51Z 置信度 0.70
• Front-matter
  crossref 2013-09-09T20:22:30Z 置信度 0.70
• Synthetic biomolecules: from blind watchmakers to synthetic biologists
  crossref Johan Winne, Annemieke Madder 2019-11-03T02:06:41Z 置信度 0.70
• Synthetic Biology: From Genetic Engineering 2.0 to Responsible Research and Innovation
  crossref Lei Pei, Markus Schmidt 2018-04-06T18:26:52Z 置信度 0.70
• Ergothioneine: from biosynthesis to sustainable biomanufacturing and health applications.
  Ergothioneine (ERG) is a naturally occurring sulfur-containing histidine derivative that has attracted considerable attention because of its exceptional chemical stability, tissue selective accumulation and potential health-promoting properties. Although human…
  pubmed Yan J, Dong H, Hao J, Ma Y 等 2026 置信度 0.82
• Ultrasound-assisted extraction enhances functional properties and in vitro digestibility of Pleurotus eryngii mycelium protein: The role of structural unfolding.
  To valorize Pleurotus eryngii mycelium protein (PeMP) as a sustainable protein source, this study investigated the efficacy of ultrasound-assisted extraction (0-450 W) in simultaneously enhancing the extraction yield and modulating the physicochemical pro…
  pubmed Zhou K, Wang Q, Li Q, Zhao N 等 2026 置信度 0.82
• Rational design of next-generation bioinoculants: Integrating molecular engineering of plant-microbe interactions with advanced formulation strategies.
  Microbial bioinoculants are increasingly positioned as key technological enablers of sustainable and climate-resilient agriculture, offering biological routes to enhance nutrient use efficiency, suppress pathogens, and improve crop tolerance to abiotic stress …
  pubmed Das S, Verma PP, Kim PJ, Raj R 2026 置信度 0.82
• Derivation of a new induced pluripotent stem cell line ORIONi004-A for modelling Duchenne muscular dystrophy.
  Anew in vitromodel for modeling Duchenne muscular dystrophy, derived from pediatric patient with a unique mutation in DMD gene is introduced. Peripheral blood was used as asource for primary cells (mononuclear cells) and subsequently reprogrammed into induced …
  pubmed Hajduchova D, Suroviakova S, Mersakova S, Nosal V 等 2026 Aug 13 置信度 0.82
• Discovery of novel dual-target CDK12/PARP1 inhibitors for the treatment of triple-negative breast cancer.
  Triple-negative breast cancer (TNBC) represents a highly aggressive breast cancer subtype characterized by a paucity of effective therapeutic options. Consequently, the development of targeted therapies constitutes a promising strategy for TNBC treatment. It h…
  pubmed Zhong ZJ, Sun M, Luo ZW, Zhao XX 等 2026 置信度 0.82
• Combinatorial Optimization of Protein Systems in Synthetic Cells.
  In vitro reconstitution of protein systems─e.g., metabolic pathways, genetic circuits, or biosensors─often requires optimization to enhance their activity. Combinatorial DNA libraries that simultaneously target multiple genes allow for a holistic…
  pubmed van den Brink M, Claassens NJ, Danelon C 2026 置信度 0.82
• Joined Signatures of Erythropoietin and Interleukin-6 Signaling by Synthetic Heterodimeric gp130:Epo Receptor Complexes.
  Synthetic engineering has shown that cytokine receptors from different families can be functionally combined to a large extent. We and others have developed fully synthetic cytokine ligand-receptor systems. Here, our synthetic cytokine receptor (SyCyR) system …
  pubmed Schlei J, Franke KF, Holzmann D, Wittich C 等 2026 置信度 0.82
• Synthesis of Tropono-β2,3-Amino Acid Derivatives via Benzene-to-Tropone Skeletal Editing.
  Tropone-based cyclic β2,3-amino acids are rare nonproteinogenic amino acid scaffolds with limited synthetic tractability. Herein, we report a concise synthesis of tropono-β2,3-amino acid derivatives from readily available phenols and nitriles via o…
  pubmed Chen HQ, Zhang BW, Wang X, Liu J 等 2026 Aug 21 置信度 0.82
• Tertiary Hydroxylamines as Bifunctional Single-Nitrogen Sources for De Novo Spirooxindole Synthesis.
  We herein report a palladium-catalyzed cascade reaction that enables the de novo synthesis of spirooxindoles from simple ortho-iodoaniline derivatives, in which tertiary O-benzoyl hydroxylamines serve as bifunctional single-nitrogen sources through sequential …
  pubmed Zhao D, Sun J, Liu J, Bai L 等 2026 Aug 21 置信度 0.82
• Inner Ear Organoids: Recent Progress and Challenges.
  Hearing loss is a prevalent sensory disorder primarily caused by the irreversible loss of cochlear hair cells and the limited regenerative capacity of the mammalian inner ear. The structural complexity and inaccessibility of inner ear tissues have long hindere…
  pubmed Li Y, He C, Liu J, Zhang H 等 2026 Aug 22 置信度 0.82
• Harnessing yeast biodiversity for advanced industrial applications.
  Budding yeast Saccharomyces cerevisiae and various non-conventional species are widely applied in the production of diverse industrial products, including pharmaceuticals, biofuels, biochemicals, and biomaterials, due to their rich natural and engineered biodi…
  pubmed Cheng C, Li YZ, Wang Z, Chen H 等 2026 Jan 5 置信度 0.82
• Tau-Targeted PROTACs Degrade Pathology-Associated Tau and Improve Memory in Alzheimer's Disease Models.
  Tau aggregation and hyperphosphorylation are key pathological features of Alzheimer's disease (AD). Because Tau is intrinsically disordered, conventional small-molecule inhibitors have achieved limited success. Proteolysis-targeting chimeras (PROTACs) enable t…
  pubmed Zhao T, Wang TY, Wang HS, Lim YJ 等 2026 Aug 21 置信度 0.82
• Reversible Redox Cycling: A Mechanism for Toxification and Detoxification in Fungal Alkyl Salicylaldehyde Biosynthesis.
  Understanding how natural product producers tolerate the reactive and toxic compounds they synthesize contributes to discovering novel therapeutics and deciphering unusual biosynthetic mechanisms. Alkyl salicylaldehydes are secondary metabolites widely distrib…
  pubmed Peng C, Jia N, Guo MY, He JJ 等 2026 Aug 22 置信度 0.82
• The gut microbiome organ.
  The human gut microbiome is increasingly viewed as an active regulator of host physiology, extending beyond earlier taxonomy-centered descriptions of a complex microbial community. Accumulating evidence supports an organ-like conceptual framework in which the …
  pubmed Bi Y, Song W, Glymenaki M, Hu J 等 2026 Aug 置信度 0.82
• Genomic signatures highlight stress-response evasion and translational tuning as key drivers of Escherichia coli adaptation to fluorinated tryptophans.
  Fluorinated amino acids profoundly perturb cellular physiology because they enter the proteome while differing from their natural counterparts in subtle but functionally important ways. Here we investigated how Escherichia coli adapts to the biosynthesis and p…
  pubmed Treiber-Kleinke C, Göller JM, Liba J, Wong MC 等 2026 Aug 21 置信度 0.82
• Deep learning-driven de novo design of ribosome binding sites in Paracoccus denitrificans.
  Paracoccus denitrificans is a heterotrophic nitrifying-aerobic denitrifying bacterium widely used in wastewater treatment and as a model system for studying electron transport chains, making it a promising chassis for environmental synthetic biology. Precise t…
  pubmed Zheng Z, Zhou S, Deng Y 2027 Mar 置信度 0.82
• Engineered eMutS based magnetic separation system for high-fidelity DNA synthesis.
  DNA synthesis fidelity remains a critical bottleneck in large-scale gene assembly. Although conventional post-synthetic purification methods (e.g., HPLC, PAGE) and enzymatic mismatch-cleavage strategies offer partial solutions, they often suffer from limited t…
  pubmed Wang X, Wang Y, Wang W, Liu W 等 2026 Sep 置信度 0.82
• Mechanism-Guided Synergistic Engineering of Substrate Access and Catalytic Microenvironment in Oxidosqualene Cyclase for Enhanced Amyrin Biosynthesis.
  Oxidosqualene cyclases (OSCs) catalyze the cyclization of 2,3-oxidosqualene into diverse triterpenoids, yet their intrinsically low catalytic efficiency restricts biosynthetic productivity. Here, we establish a mechanism-guided synergistic engineering strategy…
  pubmed Li Y, Jin K, Lu J, Huang H 等 2026 Aug 21 置信度 0.82
• Mimicking Cellular Membranes With Micropatterned Lipid Bilayers.
  Studying the role of membranes in cell biophysics requires experimental models which faithfully capture the compositional and topological complexity of cellular structures. This is particularly important for membrane structures that are just at the limit of, o…
  pubmed Nguyen TA, Xu Z, Schwille P 2026 Aug 27 置信度 0.82
• Long-term in vivo CRISPR/Cas9 gene editing in liver triggers host immunity and clonal mutations in DNA damage response genes beyond off-target effects.
  pubmed Cao T, Zhang A, Wu W, Wen J 等 2026 Aug 21 置信度 0.82
• Lauroylated peptide dendrimers with potent and broad-spectrum antimicrobial activity against multidrug-resistant bacteria.
  Peptide dendrimers, characterized by their branched structure and densely arrayed surface amino acids or peptides, offer enhanced multivalency and unimolecular stability that collectively improve receptor engagement and bioactivity. Despite these advantages, b…
  pubmed Yan A, Zhang T, Wang X, Wu S 等 2026 Aug 21 置信度 0.82
• Synthetic microalgal-bacterial symbiotic system integrating oxidase-protease fusion enzyme for simultaneous removal of recalcitrant nitrogen-containing organic compounds and PET microplastics.
  Industrial wastewaters-particularly those from the printing and dyeing sector-contain complex mixtures of recalcitrant nitrogen-containing organic compounds and microplastics that resist conventional treatment. Here we report a previously undescribed oxidase-p…
  pubmed Xiao R, Li Y, Liu P, Chou HH 2026 置信度 0.82
• Pervasive hybridization and introgression in Diervilleae (Caprifoliaceae).
  Diervilleae (Caprifoliaceae) is a horticulturally important lineage with striking floral diversity and a long history of interspecific crossing, suggesting reticulate evolution. We integrated nuclear SNPs and whole plastome data to reconstruct a phylogenomic b…
  pubmed Hao F, Sun H, Guo C, Wang Y 等 2026 Aug 22 置信度 0.82
• Metabolic engineering of Taxus chinensis suspension cell lines for overproduction of paclitaxel reveals insights into pathway regulation.
  Plant cell culture is a growing platform for sustainable biomanufacturing of plant-derived compounds, including the chemotherapeutic paclitaxel, which is produced industrially using Taxus chinensis plant cell culture. While strategies for improving yields of n…
  pubmed Newton CB, McKee MC, Harrison AM, Revene LD 等 2026 置信度 0.82
• Artificial metalloenzymes in whole-cell catalysis: Toward hybrid metabolic systems.
  The application repertoire of industrial biotechnology is constrained by the reaction scope of natural biocatalysis, which covers only a fraction of the accessible chemical space. To expand the versatility of biomanufacturing, abiological organometallic cataly…
  pubmed Slanska M, Ward TR 2026 置信度 0.82
• Enhanced cadmium phytoextraction in Brassica juncea by a hyperaccumulator-sourced synthetic inoculant.
  Synthetic communities (SynComs) of plant growth-promoting bacteria (PGPB) could enhance cadmium (Cd) phytoextraction and promote plant growth in Brassica juncea L. However, the precise molecular mechanisms of facilitated Cd uptake and accumulation remain uncle…
  pubmed Wang Q, Zhou Q, Lu M, Feng Y 等 2026 Aug 21 置信度 0.82
• Advancing Human Artificial Chromosomes at the Dawn of Synthetic Genomics.
  Human artificial chromosomes (HACs) are engineered, chromosome-scale DNA molecules that replicate and segregate autonomously in mammalian cells, offering a unique platform for large, stable, nonintegrating genetic delivery. The first generation of HACs emerged…
  pubmed Dananberg A, Birchak GJ, Black BE 2026 置信度 0.82
• Rapid fabrication of stretchable, ultratough, and rigid polymer materials.
  Polymer materials hold great promise for various applications but face trade-offs among stiffness, toughness, stretchability, and scalable fabrication. Here, we report a strategy that integrates dense side-chain hydrogen-bonding motifs capable of conformationa…
  pubmed Qiao Y, Guo K, Hao D, Li N 等 2026 置信度 0.82
• A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints.
  Antibody junctional diversity in jawed vertebrates arose from RAG transposon domestication, generating CDR3-focused V(D)J recombination with lymphocyte specificity-a constrained system limiting engineered antibody diversity. To overcome these limitations, we d…
  pubmed Liu W, Yang J, Zhang Y, Xue X 2026 Aug 21 置信度 0.82
• Milk-derived extracellular vesicles: nutritional significance, nano-delivery potential, and emerging therapeutic applications - an updated review.
  Milk-derived extracellular-vesicles (mEVs) have emerged as a promising natural nanocarriers for nutraceutical and therapeutic applications, owing to their rich cargo of bioactive proteins, lipids, microRNAs, and metabolites, coupled with their inherent biocomp…
  pubmed Wang S, Shaukat A, Al-Rasheed M, Tareen AM 等 2026 置信度 0.82
• Visualization of auxin responses during vine twining in Ipomoea nil and the functional role of the subapical hook in this process.
  This study suggests that hook-shaped bending associated with properly regulated auxin response patterns in the subapical region may contribute to the maintenance of twining in morning glory vines. The twining behavior demonstrated by vine plants represents an …
  pubmed Takarada Y, Yofune T, Yamauchi S, Funamoto M 等 2026 Aug 21 置信度 0.82
• Ancestral hydrocarbon metabolism enables PET degradation by a natural bacterial consortium.
  Plastic biodegradation in natural environments is increasingly recognized as a multi-organism process; however, the mechanisms enabling coordinated depolymerization and metabolism of polyethylene terephthalate (PET) remain poorly understood. Previously, we dem…
  pubmed Edwards S, Rice D, Palomino P, Newton I 等 2026 Aug 21 置信度 0.82
• Cyclic Thiosulfinates: Synthesis and Applications in Chemical Biology and Materials Science.
  Cyclic thiosulfinates (CTs) constitute a distinct class of organosulfur compounds characterized by a polarized ─S(═O)─S─ motif and inherent ring strain, which together dictate their unique reactivity toward thiols. Recent advances i…
  pubmed Liebson B, Agar JN, Manetsch R, Parvatkar PT 2026 置信度 0.82
• An Autolysis-Derived Trypsin Peptide Disrupts Digestive Homeostasis and Reduces Fitness in Spodoptera Frugiperda Caterpillars.
  The fall armyworm, Spodoptera frugiperda J.E. Smith (Lepidoptera: Noctuidae), is a significant agricultural pest, and its management is increasingly impeded by resistance to conventional insecticides, underscoring the need for alternative control strategies. T…
  pubmed Paulo DGS, Meriño-Cabrera Y, Severiche-Castro J, Braga PF 等 2026 Aug 18 置信度 0.82
• Rapid, expression-free bacteriophage-based specific detection of target bacteria by conditional release of encapsidated reporter molecules.
  Rapid diagnosis of infectious diseases is of paramount importance to prevent or control outbreaks and pandemics. Detection of bacteria is commonly performed using culture-based and molecular detection methods, which cannot address the need for quick, specific …
  pubmed Avramucz Á, Wheatley JP, Liyanagedera SBW, Fehér T 等 2026 Aug 20 置信度 0.82
• Natural polysaccharides as immune adjuvants to overcome immune checkpoint inhibitor resistance: mechanistic insights, clinical evidence, and translational challenges.
  Immune checkpoint inhibitors (ICIs) have redefined the treatment landscape of advanced malignancies, yet primary and acquired resistance severely limits their therapeutic efficacy across most solid tumors. Even in biomarker-stratified patient cohorts, objectiv…
  pubmed Li Y, Qian J, Zhou S, Wang C 等 2026 置信度 0.82
• Reversible Coordination Modes in Piperazine-Based Ru(II)-p-Cymene Acylthiourea Complexes: Modulating DNA Groove Binding for Selective Antimelanoma Activity.
  Acylthiourea ligands, featuring hard (N, O) and soft (S) donor atoms, enable diverse coordination modes in half-sandwich Ru(II)-p-cymene complexes. Herein, we report the synthesis and full characterization of eight half-sandwich Ru(II)-p-cymene complexes, comp…
  pubmed Karim A, Wang X, Chu YT, Malekshah RE 等 2026 Aug 27 置信度 0.82
• Advanced gene editing technologies for oncology mechanisms, applications, and clinical implementation.
  Advanced gene editing tools have transformed oncology by facilitating precise molecular therapies aimed at the hereditary basis of cancer. This thorough study examines the mechanisms, applications, and clinical implementation of advanced genome editing technol…
  pubmed Bindu S, Ash A, Sarkar K 2026 置信度 0.82
• Brain barriers at the crossroads of glioma immune surveillance and immunotherapy response.
  Immunotherapies have substantially advanced cancer treatment; however, their efficacy in gliomas remains limited. This observation cannot be fully explained by tumour-intrinsic factors and may rather be linked to the distinct relationship between the central n…
  pubmed Engelhardt B, Platten M 2026 Aug 20 置信度 0.82
• Coarse-grained resource allocation modeling for decoding and rewiring microbial metabolism.
  Microbial metabolism is a complex, emergent system driven by the coordinated interplay of intricate and dynamic molecular processes. To elucidate cellular behavior and enable biotechnological applications, quantitative models that address the inherent complexi…
  pubmed Lai YH, Lu T 2026 Aug 20 置信度 0.82
• Chromatin immunoprecipitation assay for analyzing histone H3-mediated regulation of copper homeostasis.
  Histone tails undergo various post-translational modifications that aid in recruiting effector proteins involved in diverse transcriptional responses. Our previous work explored the role of histone H3 N-terminal residues and their modifications on the transcri…
  pubmed Singh S, Sahu RK, Tomar RS 2026 置信度 0.82
• Therapeutic targeting of G protein-coupled receptors in central nervous system disorders: from novel mechanisms to precision pharmacology.
  G protein-coupled receptors (GPCRs) are major therapeutic targets for central nervous system disorders, with more than 500 approved drugs targeting this receptor family worldwide. This review comprehensively examines the pathophysiological roles and therapeuti…
  pubmed Zhou C, Zhu C, Wang X, Yang Y 等 2026 Aug 20 置信度 0.82
• The genomic alchemist's arsenal: A comprehensive review of gene recruitment, regulatory rewiring, and the evolutionary arms race in snake envenomation.
  Snake venom represents a striking example of evolutionary innovation, in which ancestral physiological gene networks have been co-opted into potent biochemical weapons. Advances in multi-omics, single-cell genomics, and structural bioinformatics have catalyzed…
  pubmed Ajeh IJ, Ikukpla'si OSI 2026 Aug 20 置信度 0.82
• The molecular mechanisms and therapeutic targeting of microtubule glutamylation in mitosis and cancer.
  Microtubule glutamylation is a dynamic post-translational modification that involves the addition of glutamate chains to tubulin, a process crucial for reshaping the biochemical interface of microtubules. This modification orchestrates an array of vital cellul…
  pubmed Li K, Sun S 2026 Aug 20 置信度 0.82
• Engineered mechanosensitive MSCs enable synthetic radiotheranostic targeting across tumor types.
  Radiopharmaceutical-based imaging and targeted radionuclide therapy are often limited by heterogeneous or absent molecular targets in tumors. Here, we present a stiffness-responsive mesenchymal stem cell (MSC)-assisted relayed tumor-targeting (SMART) platform …
  pubmed Yang X, Yin Q, Li K, Wang J 等 2026 Aug 20 置信度 0.82
• An insoluble de novo protein enables survival of Escherichia coli by sequestering a gene repressor.
  De novo proteins that share no ancestry with natural sequences can serve as additions to the evolved proteomes of living cells. Upon expression in cells, these novel proteins can provide biological functions that alter cell viability and growth. To isolate suc…
  pubmed Liao G, Tao S, Dessau JL, Bann Y 等 2026 Aug 25 置信度 0.82
• Simplifying Multiplex Genome Engineering in Saccharomyces cerevisiae with Intron-mediated Random Assembly and INtegration (RAIN).
  Engineering of multi-step enzymatic pathways often involves extensive optimisation of heterologous gene expression levels and requires cloning of promoter and open reading frames (ORFs) to generate expression cassettes. We present work on a nascent method for …
  pubmed Harrison FS, Kelso PA, Carpenter AC, Hawthorne C 等 2026 Aug 20 置信度 0.82
• Evidence for a Cu(II)-Catalysed CuAAC Reaction: A Combined Experimental and Computational Study.
  The Cu-catalysed azide-alkyne cycloaddition (CuAAC) reaction is one of the most broadly applied catalytic processes, with applications throughout synthetic chemistry, drug discovery, chemical biology, and materials science. This field of research is built upon…
  pubmed Andrews MJ, Richardson TM, Roberts DD, Maestro A 等 2026 Aug 20 置信度 0.82
• Quantifying the Sequence-Dependent Kinetic Protection of Reduced Heme in Peptide Amphiphile Nanofibers.
  Replicating the protective dielectric environment of natural cytochromes within synthetic assemblies is essential for the development of air-stable bioelectronics. We report a redox-triggered "supramolecular gate" in self-assembled peptide amphiphile (PA) nano…
  pubmed Campbell B, Rogers A, Hernandez-Martinez NA, Dangi S 等 2026 Aug 20 置信度 0.82
• Rapid Exonuclease-Based De Novo Sequencing Strategy for Long Oligonucleotides via Liquid-Phase Ion Trap Coupled With Mass Spectrometry.
  The sequencing of synthetic oligonucleotides is fundamental to life sciences and therapeutics, yet current analytical approaches present inherent technical drawbacks of varying degrees. Hybridization-based techniques cannot sequence the oligonucleotide primers…
  pubmed Lu S, Hong J, Fu X, Wang D 等 2026 Aug 20 置信度 0.82
• Application of bacteriophages in the prevention and control of bacterial infectious diseases in animals.
  The global spread of antimicrobial resistance (AMR) has intensified the search for alternatives to conventional antibiotics in animal production systems. Bacteriophages can be engineered beyond narrow-spectrum antibacterial agents into multifunctional biologic…
  pubmed Li J, Zhang H, Yu H, Liang P 等 2026 置信度 0.82
• Development of an inducible stable producer cell line for rAAV production.
  Adeno-associated virus (AAV) is a widely preferred in vivo gene therapy vector for clinical trials due to its numerous advantages. However, manufacturing recombinant AAV (rAAV) using transient transfection methods poses significant challenges. Stable cell line…
  pubmed Fu Q, Wang Y, Doleh E, Blenner M 等 2026 Jun 置信度 0.82
• Antischistosomal Ozonide Glycine Ethyl Esters.
  Building on the discovery that synthetic ozonides have not only antimalarial but also antischistosomal properties, we now report the synthesis and antischistosomal activity of a series of ozonide glycine ethyl esters. We identified ozonide glycine zwitterion 1…
  pubmed Ren R, Häberli C, Chen G, Singh SK 等 2026 Aug 13 置信度 0.82
• Leaching of Di(2-ethylhexyl) Phthalate from Polyvinyl Chloride Microplastics in Synthetic Freshwater, Seawater, and Fish In Vitro Digestion Fluids.
  We investigated the leaching of additives from microplastics (MPs) derived from commercial polyvinyl chloride (PVC) wire insulation into synthetic freshwater, synthetic seawater, and a fish in vitro digestion system. The experiments used an MP loading of 1 mg …
  pubmed Cai R, Sharma P, Rhodes V, Thennakoon D 等 2026 Aug 14 置信度 0.82
• Lipophilic Ligand Efficiency-Monitored Discovery of Potent, Achiral, and Bioavailable Apo-IDO1 Inhibitors.
  The indoleamine 2,3-dioxygenase 1 (IDO1) enzyme promotes an immunosuppressive microenvironment and disrupts natural antitumor immune response in cancer cells. IDO1 inhibition has been a target of multiple cancer immunotherapy efforts and is of interest to auto…
  pubmed Kazmierski WM, Miriyala N, De la Rosa M, Miller J 等 2026 Aug 13 置信度 0.82
• Computational alanine scanning with GBSA and interaction entropy: a review of methodologies and applications in protein-protein and protein-ligand binding.
  Computational alanine scanning (CAS) has emerged as a powerful in silico strategy for identifying binding hot spots in protein-protein and protein-ligand complexes, addressing the limitations of experimental alanine scanning mutagenesis. This review provides a…
  pubmed Liu X, Xu X, Duan LL, Zhang JZH 2026 Aug 13 置信度 0.82
• High-resolution long-read sequencing maps genomic Island-associated gene duplication in South African carbapenem non-susceptible Pseudomonas aeruginosa.
  Carbapenem non-susceptible Pseudomonas aeruginosa is a major global health threat driven by the spread of high-risk lineages, but the genomic architecture of resistance evolution is often unresolved by short-read sequencing.
  pubmed Cave R, Patel F, Africa SD, Moodley C 等 2026 置信度 0.82
• PhaseTransfer: A transfer learning framework for efficient phase diagram mapping.
  Self-driving laboratories accelerate materials discovery by autonomously designing and executing experiments through closed-loop integration of robotics and artificial intelligence. Active learning with Gaussian processes has enabled efficient phase diagram ma…
  pubmed González-García E, Markvoort AJ, Erkamp NA, de Greef TFA 2026 置信度 0.82
• In vivo reconstruction of the cell lineage history of a developing mouse with DNA Typewriter, from zygote to late organogenesis.
  The complete cell lineage of C. elegans , mapped over four decades ago, was tractable because the animal is small, transparent, and lineage invariant 1 . Most animals are none of these, having orders of magnitude more cells, being opaque, and developing with s…
  pubmed Yu Q, Kim H, Seidel S, Acosta-Clark JF 等 2026 Jul 30 置信度 0.82
• Agrochemical-responsive gene expression control systems for modulating plant development and metabolism.
  Precise temporal control of gene expression is critical for studying plant biology and engineering complex crop traits. Current systems enable chemically inducible regulation but rely on costly or agriculturally impractical inducers and lack the flexibility ne…
  pubmed Bull T, Farina L, Sutton S, Van Blair J 等 2026 置信度 0.82
• TipQuant: a robust algorithm for quantitative analysis of spatiotemporally dynamic activities in tip-growing cells.
  Cell polarity and tip growth rely on the dynamic spatial organization of signaling and structural components. Quantitative characterization of these spatiotemporal dynamics is critical for understanding polarized cell growth, yet manual quantification is labor…
  pubmed Guo J, Le Gouic J, Rosenthal R, Zou A 等 2026 Aug 20 置信度 0.82
• Extracellular matrix targeting peptide functionalized plant-derived lipid nanoparticles for gene therapy in osteoarthritis.
  The pathogenesis of osteoarthritis (OA) involves the degradation of the extracellular matrix (ECM) of cartilage, which is mainly mediated by matrix metalloproteinases (MMPs). Small interfering RNA (siRNA)-based gene therapy has shown promise in treating variou…
  pubmed Iqbal Z, Shabbir M, Rasul F, Xia J 等 2026 Aug 19 置信度 0.82
• Engineering a genetic construct to express soluble proteins tethered to the cell membrane.
  Synthetic biology has significantly grown and developed in the last decades, allowing its implementation in a wide variety of fields and applications. However, there is a lack of versatile, modular tools that allow the expression of soluble proteins anchored t…
  pubmed Ronco-Campaña A, Simms J, Goddard AD, Rothnie AJ 2026 Aug 19 置信度 0.82
• Targeting Adaptive and Innate Immune Responses with Covalent Aptamers.
  Covalent aptamers have recently found initial success as tools for fast and selective transfer of labels to target proteins. Here, aptamers targeting protein tyrosine kinase 7 (PTK7) and the mesenchymal-epithelial transition factor (cMet) were functionalized w…
  pubmed Albright S, Parikh A, Cacace M, Rosenblum C 等 2026 Aug 19 置信度 0.82