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• Synthetic Universes Project: Cosmology and Technology Papers
  Collection of 38 papers by Denise Venerable and Grok 3 (xAI) representing the foundational phase of the Synthetic Universes Project. This body of work explores the structure of a threefold cosmos comprising holographic, flat, and saddle universes, as well as r…
  datacite Venerable, Denise, xAI, Grok 3 2025 置信度 0.66 Synthetic Universes, Quantum Mechanics, General Relativity, Tensors, Hilbert Spaces, Wormholes, Holographic Duality, Meta-Consciousness, Quantum Biology, Propulsion, Simulation Theory, CMB-S4, Quantum Gravity, Quantum Computing, Energy Harvesting, Technology Evolution
• Dataset for "Deciphering guanidine assimilation and riboswitch-based gene regulation in cyanobacteria for synthetic biology applications"
  This is the corresponding Berkeley Madonna script used to simulate the guanidine-dependent steady-state bioprocess graphically presented in Figure 5 of the publication "Itzenhäuser MA, Enkerlin AM, Dewald JA, Avşar B, Stauder R, Halpick H, Schaale R, Baumann L…
  datacite Itzenhäuser, M Amadeus, Klähn, Stephan 2026 置信度 0.66 Guanidinebioprocess
• Reflective Reality Evolution Framework: A Quantitative Reality-Density Metric for Macro-Evolution
  This is the work of Dean Michael Taylor. Reflective Reality Evolution Framework A Quantitative Reality-Density Metric for Macro-Evolution, Punctuated Equilibrium, and Anthropogenic Adaptation Version: 1.0 (May 17, 2026) Creators: Dean Michael Taylor License: C…
  datacite Taylor, Dean 2026 置信度 0.66
• Reflective Reality Evolution Framework: A Quantitative Reality-Density Metric for Macro-Evolution
  This is the work of Dean Michael Taylor. Reflective Reality Evolution Framework A Quantitative Reality-Density Metric for Macro-Evolution, Punctuated Equilibrium, and Anthropogenic Adaptation Version: 1.0 (May 17, 2026) Creators: Dean Michael Taylor License: C…
  datacite Taylor, Dean 2026 置信度 0.66
• Lux Ferox Research Collective — A Holographic-Thermodynamic Ontology of Information: From Planck-Scale Substrates to Civilizational Cognitive Warfare
  Lux Ferox Research Collective — A Holographic-Thermodynamic Ontology of Information: From Planck-Scale Substrates to Civilizational Cognitive Warfare (Working Paper Series, v16 — April 2026) DESCRIPTION Lux Ferox is an independent research initiative applying …
  datacite MATHIEU, François 2026 置信度 0.66 Artificial intelligenceArtificial IntelligenceMilitary ScienceMilitary FacilitiesMilitary equipment
• Lux Ferox Research Collective — A Holographic-Thermodynamic Ontology of Information: From Planck-Scale Substrates to Civilizational Cognitive Warfare
  Lux Ferox Research Collective — A Holographic-Thermodynamic Ontology of Information: From Planck-Scale Substrates to Civilizational Cognitive Warfare (Working Paper Series, v16 — April 2026) DESCRIPTION Lux Ferox is an independent research initiative applying …
  datacite MATHIEU, François 2026 置信度 0.66 Artificial intelligenceArtificial IntelligenceMilitary ScienceMilitary FacilitiesMilitary equipment
• EIC ELMs Portfolio Workshop "Regulatory Readiness for emerging biotechnology solutions through the lens of Engineered Living Materials"
  Engineered Living Materials (ELMs) represent a biotechnology-based innovative frontier in material science, combining biological organisms with material engineering to create environmentally responsive substances. These materials harness the capabilities of li…
  datacite Gerratana, Barbara 2026 置信度 0.66 engineered living materialssynthetic biologyadvanced materialsorganoidsbioprinting
• "Beyond Scaffolding: Parametric Specialisation via Continual LoRA on a Personal Research Corpus — A Pre-Registered Controlled Comparison"
  # Pre-Registration: JCAE Phase 2 — Continual LoRA Specialisation **Title:** Beyond Scaffolding: Parametric Specialisation via Continual LoRA on a Personal Research Corpus — A Pre-Registered Controlled Comparison **Authors:** Juan David Zuluaga-Monroy, Diego Fe…
  datacite Zuluaga-Monroy, Juan David, Zuluaga-Monroy, Diego Fernando 2026 置信度 0.66 Engineering
• Collection Flyer: Innovative Approaches in Enhancing Abiotic Stress Tolerance in Crops
  This flyer promotes the Springer Nature Discover Agriculture Collection titled “Innovative Approaches in Enhancing Abiotic Stress Tolerance in Crops” , launched in June 2025. The Collection focuses on cutting-edge strategies for improving crop resilience to dr…
  datacite Farooq, Dr. Muhammad 2025 置信度 0.66 Agricultural biotechnology not elsewhere classifiedAgronomyCrop and pasture biochemistry and physiologySynthetic biologyProteomics and intermolecular interactions (excl. medical proteomics)
• Universal Patterns or Divine Reflections? A Philosophical Exploration of Numerology and Sacred Geometry in Non-Christian Traditions, Engaging an Eastern Orthodox Christian Perspective
  This article is also available on ResearchGate.net, at: https://www.researchgate.net/publication/395695875_Universal_Patterns_or_Divine_Reflections_A_Philosophical_Exploration_of_Numerology_and_Sacred_Geometry_in_Non-Christian_Traditions_Engaging_an_Eastern_Or…
  datacite Carp, Theodor-Nicolae 2026 置信度 0.66 Comparative religious studiesReligion, society and culturePhilosophy of religionPhilosophy of cognitionPoststructuralism
• Lux Ferox Research Collective — A Holographic-Thermodynamic Ontology of Information: From Planck-Scale Substrates to Civilizational Cognitive Warfare
  Lux Ferox Research Collective — A Holographic-Thermodynamic Ontology of Information: From Planck-Scale Substrates to Civilizational Cognitive Warfare (Working Paper Series, v16 — April 2026) DESCRIPTION Lux Ferox is an independent research initiative applying …
  datacite MATHIEU, François 2026 置信度 0.66 Artificial intelligenceArtificial IntelligenceMilitary ScienceMilitary FacilitiesMilitary equipment
• The Infinite Continuum: A framework for consciousness, existence, and the self
  The Infinite Continuum: A framework for consciousness, existence, and the self proposes a fundamental reorientation of the consciousness debate. Rather than asking how the brain generates subjective experience — the generator model's approach, which produces t…
  datacite Wharton, Max 2026 置信度 0.66 Hard problemConsciousnessFilter modelQuantum coherenceMicrotubules
• The Infinite Continuum: A framework for consciousness, existence, and the self
  The Infinite Continuum: A framework for consciousness, existence, and the self proposes a fundamental reorientation of the consciousness debate. Rather than asking how the brain generates subjective experience — the generator model's approach, which produces t…
  datacite Wharton, Max 2026 置信度 0.66 Hard problemConsciousnessFilter modelQuantum coherenceMicrotubules
• Lux Ferox Research Collective — A Holographic-Thermodynamic Ontology of Information: From Planck-Scale Substrates to Civilizational Cognitive Warfare
  Lux Ferox Research Collective — A Holographic-Thermodynamic Ontology of Information: From Planck-Scale Substrates to Civilizational Cognitive Warfare (Working Paper Series, v16 — April 2026) DESCRIPTION Lux Ferox is an independent research initiative applying …
  datacite MATHIEU, François 2026 置信度 0.66 Artificial intelligenceArtificial IntelligenceMilitary ScienceMilitary FacilitiesMilitary equipment
• From Mutation to Medicine: A Computational Framework for Cancer Target Prediction and Drug Alignment
  # Fractal Correction Engine Applied to Cancer Mutation Hotspot Analysis: Pi-Based Curvature Extraction and Golden Ratio Self-Similarity in Genomic Mutation Density Profiles **Author**: Adam L. McEvoy**Version**: 4.0**Date**: March 2026 ## Abstract **Background…
  datacite McEvoy, Adam L 2026 置信度 0.66 Cancer GenomicsMutation PredictionOncogenic DriversTumor Suppressor GenesPrecision Oncology
• Digital Autopoiesis: A Treatise on the Emergence of Analog Vitality from the Nexus Framework
  Digital Autopoiesis: A Treatise on the Emergence of Analog Vitality from the Nexus Framework Driven By Dean Kulik Part I: Foundations of Emergent Complexity Section 1.0 The Computational Substrate: From Discrete Iteration to Continuous Phenomena The propositio…
  datacite Kulik, Dean 2025 置信度 0.66
• Recursive Harmonic Substrate: Unified System Map, Implementation, Language, Interface & Diagnostics
  Recursive Harmonic Substrate: Unified System Map, Implementation, Language, Interface & Diagnostics In this unified model, concepts from cryptographic hashing, prime number theory, physical fields, and recursion all converge into a single recursive harmonic su…
  datacite Kulik, Dean 2025 置信度 0.66
• The Metaphysics of Blooming: An Analysis of Pressure, Reflection, and Silence in Complex Systems
  The Metaphysics of Blooming: An Analysis of Pressure, Reflection, and Silence in Complex Systems Driven By Dean Kulik August, 2025 Introduction: From Ripples to Reality The human endeavor to comprehend the universe often proceeds along two parallel paths: the …
  datacite Kulik, Dean 2025 置信度 0.66
• The Hidden Code of Coherence: An Algorithm That Imitates Life's Self-Regulation
  The Hidden Code of Coherence: An Algorithm That Imitates Life’s Self-Regulation Driven by Dean A. Kulik November, 2025 Introduction: From Static Code to Living Process A new computational framework has emerged that behaves less like a traditional algorithm and…
  datacite Kulik, Dean 2025 置信度 0.66
• The Nexus Unitary Optimization Field: A Formal Framework for Cross-Domain Self-Optimization
  The Nexus Unitary Optimization Field: A Formal Framework for Cross-Domain Self-Optimization Driven by Dean A. Kulik October, 2025 Abstract The Nexus Unitary Optimization Field (denoted 𝓜) is introduced as a comprehensive mathematical and computational framewo…
  datacite Kulk, Dean 2025 置信度 0.66
• The Metaphysics of Blooming: An Analysis of Pressure, Reflection, and Silence in Complex Systems
  The Metaphysics of Blooming: An Analysis of Pressure, Reflection, and Silence in Complex Systems Driven By Dean A. Kulik August, 2025 – Version 3. Introduction: From Ripples to Reality The human endeavor to comprehend the universe often proceeds along two para…
  datacite Kulik, Dean 2025 置信度 0.66
• Nanobody-Based Lateral Flow Assay for Rapid Zika Virus Detection
  ACS synthetic biology 14(3), 890-900 (2025). doi:10.1021/acssynbio.4c00819
  datacite Peng, Yuli, Alqatari, Atheer, Kiessling, Fabian, Renn, Dominik 等 2025 置信度 0.66
• The Grand Synthesis: Universal Triadic Closure, the Shape-Value Duality,and the Helix of Existence as One Law
  The Grand Synthesis: Universal Triadic Closure, the Shape-Value Duality,and the Helix of Existence as One Law Driven by Dean Kulik April 2026 Abstract This document is the canonical synthesis of the NEXUS research program through Phase 1271. It shows that thre…
  datacite Kulik, Dean 2026 置信度 0.66
• The Grand Synthesis: Universal Triadic Closure, the Shape-Value Duality,and the Helix of Existence as One Law
  The Grand Synthesis: Universal Triadic Closure, the Shape-Value Duality,and the Helix of Existence as One Law Driven by Dean Kulik April 2026 Abstract This document is the canonical synthesis of the NEXUS research program through Phase 1271. It shows that thre…
  datacite Kulik, Dean 2026 置信度 0.66
• Disease Agnostic Pathway Subtyping Framework
  A disease-agnostic framework for pathway-based molecular subtype discovery in genetically heterogeneous conditions. Changelog All notable changes to the Pathway Subtyping Framework will be documented in this file. The format is based on Keep a Changelog, and t…
  datacite Chauhan, Rohit 2026 置信度 0.66 bioinformaticsgenomicspathway analysismolecular subtypingrare variants
• The Architecture of Semantic Collapse: Spectral Dynamics, Tail-Residue Runtimes, and the Thermodynamic Emergence of Meaning
  The Architecture of Semantic Collapse: Spectral Dynamics, Tail-Residue Runtimes, and the Thermodynamic Emergence of Meaning Introduction The transition from discrete syntactical manipulation to continuous semantic reasoning in advanced computational systems ma…
  datacite Kulik, Dean 2026 置信度 0.66
• The Architecture of Semantic Collapse: Spectral Dynamics, Tail-Residue Runtimes, and the Thermodynamic Emergence of Meaning
  The Architecture of Semantic Collapse: Spectral Dynamics, Tail-Residue Runtimes, and the Thermodynamic Emergence of Meaning Introduction The transition from discrete syntactical manipulation to continuous semantic reasoning in advanced computational systems ma…
  datacite Kulik, Dean 2026 置信度 0.66
• Dual-responsive synthetic gene circuit for dynamic biologic drug delivery via inflammatory and circadian signaling pathways
  Abstract Background Engineered cells provide versatile tools for precise, tunable drug delivery, especially when synthetic stimulus-responsive gene circuits are incorporated. In many complex disease conditions, endogenous pathologic signals such as inflammatio…
  crossref Amanda Cimino, Fiona Pat, Omolabake Oyebamiji, Christine T.N. Pham 等 2025-03-23T02:07:04Z 置信度 0.70
• Challenges and Opportunities in Smart Biosensing for Biomanufacturing
  europepmc Mara Pisani, Pablo Carbonell 2025 置信度 0.80
• Increased maize chromosome number by engineered chromosome fission
  Activation of synthetic centromeres on chromosome 4 in maize leads to its breakage and formation of trisomic fragments called neochromosomes. A limitation of neochromosomes is their low and unpredictable transmission rates due to trisomy. Here we report that s…
  crossref Yibing Zeng, Mingyu Wang, Jonathan Isaiah Gent, R. Kelly Dawe 2025-02-05T22:50:30Z 置信度 0.70
• Accurate prediction of gene deletion phenotypes with Flux Cone Learning
  Abstract Predicting the impact of gene deletions is crucial for biological discovery, biomedicine, and biotechnology. For example, identifying lethal deletions is key for new cancer therapies or antimicrobial treatments that bypass drug resistance. In biotechn…
  crossref Charlotte Merzbacher, Oisin Mac Aodha, Diego A. Oyarzún 2025-06-20T21:15:19Z 置信度 0.70
• Design Principles for Polymerase Strand Recycling Circuits
  Cell-free biosensing systems are being engineered as versatile and programmable diagnostic technologies. A core component of cell-free biosensors are programmable molecular circuits that improve biosensor speed, sensitivity and specificity by performing molecu…
  crossref Yueyi Li, Arno E. Gundlach, Andrew D. Ellington, Julius B. Lucks 2025-03-19T17:10:02Z 置信度 0.70
• Synthetic biology, AI and automation
  crossref 2025-11-26T17:00:22Z 置信度 0.70
• Root Contours Guided Design of a Multicellular PID Controller
  Abstract Ensuring a stable and robust phenotype expression is a key challenge for the correct operation of synthetically engineered cells, and feedback has been highlighted as a key mechanism to achieve this goal. Biomolecular PID controllers have been extensi…
  crossref Vittoria Martinelli, Davide Fiore, Davide Salzano, Mario di Bernardo 2025-05-05T20:05:16Z 置信度 0.70
• Renewable Self-Folding Origami Constructed from Bioengineered Bacterial Cellulose
  Abstract This work presents the first genetically engineered cellulose actuator where the structural basis for actuation is directly encoded in the producing organism’s DNA. By modifying Komagataeibacter rhaeticus to secrete BslA protein and treating with NaOH…
  crossref Yitong Tseo, Morgan Guempel, Cathy Hogan, Ian Hunter 2025-08-23T05:20:34Z 置信度 0.70
• A Parametric Robustness versus Dynamic Sensitivity Paradox in a Bistable Biomolecular Circuit
  Abstract Achieving robustness to multi-parametric perturbations where all parameters can change at the same time is challenging because the controller would also face the same disturbance as the plant. For nonlinear positive feedback, an important mechanism fo…
  crossref Gunjan Chorasiya, Rudra Prakash, Shaunak Sen 2025-01-24T18:10:17Z 置信度 0.70
• A Straightforward and Robust Enzymatic Reporter System for Anaerobic Thermophiles
  Abstract Thermophilic anaerobic organisms, particularly species that can naturally degrade lignocellulosic biomass, show great promise for next generation bioprocessing. This has led to the development of nascent genetic systems to metabolically engineer these…
  crossref Joey L. Galindo, Hansen Tjo, Jonathan M. Conway 2025-06-24T00:00:14Z 置信度 0.70
• Design of a Modular Inducible Circuit for Pulsatile Population Control of Engineered Bacteria
  ABSTRACT Synthetic biology enables the precise control of bacterial population dynamics through engineered genetic circuits, paving the way for innovative therapeutic and biosensing applications. Here, we present genetic circuit design that leverages AHL (acyl…
  crossref Rohita Roy, Michaëlle N. Mayalu 2025-05-04T23:25:13Z 置信度 0.70
• Regulating population density through antithetic feedback control of cell growth
  Abstract We present a genetic feedback control strategy enabling engineered microorganisms to self-regulate their population density. Our approach leverages a quorum sensing mechanism for the production of a growth inhibitor protein, whose activation is regula…
  crossref Giovanni Campanile, Vittoria Martinelli, Davide Salzano, Davide Fiore 2025-04-23T11:57:31Z 置信度 0.70
• Multiobjective learning and design of bacteriophage specificity
  Abstract To better understand and design proteins, it is crucial to consider the multifunctional landscapes on which all proteins exist. Proteins are often optimized for single functions during design and engineering, without considering the countless other fu…
  crossref Naia Novy, Phil Huss, Sarah Evert, Philip A. Romero 等 2025-05-20T05:24:15Z 置信度 0.70
• Promoter-Driven Modulation of Flagellin Expression and Motility in <i>Escherichia coli</i>
  Abstract Synthetic biology offers powerful tools to engineer biological systems for diverse applications. However, key challenges persists before achieving real-world applications like environmental bioremediation or therapeutic microrobots for targeted drug d…
  crossref Karima Bharati Bayana, Xinyue Wang 2025-01-31T21:50:20Z 置信度 0.70
• Artificial Intelligence in Synthetic Biology
  crossref Naorem Bela Devi, Suparna Sen, Kannan Pakshirajan 2025-03-14T08:27:11Z 置信度 0.70
• Investigating the Impact of Measurement Variance on Gene Circuit Model Parameterization
  Summary Ordinary differential equation (ODE)-based modeling is a powerful tool in the design and characterization of synthetic gene circuits. Despite its popularity, identifying the model parameters based off experimental measurement is a nontrivial task. In t…
  crossref Thales R. Spartalis, Wan Tang, Xun Tang 2025-04-02T23:35:12Z 置信度 0.70
• Intelligent Design of <i>Escherichia coli</i> Terminators
  Abstract Terminators are specific nucleotide sequences located at the 3’ end of a gene and contain transcription termination information. As a fundamental genetic regulatory element, terminators play a crucial role in the design of gene circuits. Accurately ch…
  crossref Jie Li, Lin-Feng Wu, Kai Liu, Bin-Guang Ma 2025-03-04T23:45:26Z 置信度 0.70
• Pathway Design and Optimization in Synthetic Biology for Flavonoids and Stilbenoids Bioproduction
  crossref Hongbiao Li, Fuqiang Song, Jingwen Zhou 2025-11-05T06:28:36Z 置信度 0.70
• Coupling Electrocatalysis and Biotransformation for CO2-Based Biomanufacturing
  crossref Huijuan Cui, Xuan Wang, Lingling Zhang 2025-06-22T20:26:04Z 置信度 0.70
• Synthetic biology in Mexico: Brief history, current landscape, and perspectives towards a bio‐based economy
  Abstract Synthetic biology (SynBio) makes biology easier by leveraging engineering principles and other disciplines to design and construct biological systems with novel or enhanced functions. SynBio has led to the development of more sustainable biotechnologi…
  crossref Uriel E. Barboza‐Pérez, Ma de L. Pérez‐Zavala, José E. Barboza‐Corona 2025-01-07T07:15:51Z 置信度 0.70
• Review on Advancement of AI in Synthetic Biology
  crossref Ishita Mirchandani, Yaminee Khandhediya, Kshipra Chauhan 2025-06-23T23:13:59Z 置信度 0.70
• BRCAness Identifies Synthetic Cytotoxicity Between Cisplatin and Radiation Therapy
  crossref Kerstin Borgmann, David Krug 2025-02-03T04:13:56Z 置信度 0.70
• Microbial biotechnology: from synthetic biology to synthetic ecology
  crossref Qingyun Yan, Yuzhen Ming, Jianzhong Liu, Huaqun Yin 等 2025-01-02T21:01:19Z 置信度 0.70
• AI-Based Antibody Design Targeting Recent H5N1 Avian Influenza Strains
  In 2025 alone, H5N1 avian influenza is responsible for thousands of infections across various animal species, including avian and mammalian livestock such as chickens and cows, and poses a threat to human health due to avian-to-mammalian transmission. There ha…
  crossref Nicholas Santolla, Colby T. Ford 2025-04-25T00:00:12Z 置信度 0.70
• Designing Convergent Overlapping Genes with Transformer Encoder Models and Lightweight Structural Proxies
  Abstract Overlapping genes allow multiple proteins to be encoded from a single DNA sequence, including convergent (antisense; tail-to-tail) orientations across three reading frames (phases 0, 1, and 2), with phase 1 most frequently observed in nature. Designin…
  crossref Jason K. Morgan 2025-11-10T18:50:20Z 置信度 0.70
• OligoSeq: Rapid nanopore-sequencing of single-stranded oligonucleotides
  Nanopore-based DNA sequencing technology has achieved remarkable success in sequencing increasingly long DNA strands (e.g. over a million nucleotides long) for genomics research and biotechnology applications. However, the same level of progress has not been a…
  crossref Robert Ramirez-Garcia, Akashaditya Das, Thomas Heinis 2025-06-10T23:55:14Z 置信度 0.70
• Synthetic biology-driven microbial therapeutics: Integrated platforms for disease diagnosis and intervention
  Synthetic biology made the design of microbes as versatile therapeutic platforms possible, thereby transforming bacteria and synthetic microbial communities into programmable systems for health applications. This review summarizes recent progress in engineered…
  openalex Fangyuan Ye, Hao Zheng 2025-01-01 置信度 0.72 DiseaseSynthetic biologyIntervention (counseling)Risk analysis (engineering)Medicine
• Synthetic biology of acetogenic bacteria for sustainable C1 gas bioconversion
  crossref B Cho 2025-07-07T19:26:50Z 置信度 0.70
• Synthetic niches enable co-culture bioprocessing but are prone to mutational escape
  Abstract Stabilizing microbial co-cultures is a central challenge for bioproduction. While division of labor between strains can enhance efficiency, it often results in population instability over time. Classical strategies, including cross-feeding, quorum sen…
  crossref Vincent Vandenbroucke, Juan Andrés Martínez, Lucas Henrion, Andrew Zicler 等 2025-11-26T02:45:11Z 置信度 0.70
• Plant Synthetic Biology to Revolutionize Agriculture
  Plant synthetic biology, which merges engineering principles with plant biology, offers transformative potential to address global food security challenges driven by rapid population growth and environmental change. This emerging field enables the conceptualiz…
  crossref Radhika R 2025-10-21T12:29:25Z 置信度 0.70
• Plant synthetic biology‐based biofortification, strategies and recent progresses
  ABSTRACT Hidden hunger, caused by chronic micronutrient deficiencies, affects billions of people worldwide and remains a critical public health issue despite progress in food production. Biofortification offers a promising solution by enhancing nutrient levels…
  crossref Kai Wang, Zhongchi Liu 2025-05-16T04:45:50Z 置信度 0.70
• Synthetic Biology Governance and Advocacy
  crossref Melodena Stephens, Abhishek Balakrishnan 2025-01-15T04:24:01Z 置信度 0.70
• Machine learning-assisted synthetic biology of cyanobacteria and microalgae
  crossref Weijia Jin, Fangzhong Wang, Lei Chen, Weiwen Zhang 2025-01-11T23:26:08Z 置信度 0.70
• Review for "Synthetic biology and metabolic engineering paving the way for sustainable next-gen biofuels: a comprehensive review"
  crossref 2025-08-21T21:06:07Z 置信度 0.70
• Review for "Synthetic biology and metabolic engineering paving the way for sustainable next-gen biofuels: a comprehensive review"
  crossref 2025-08-21T21:06:07Z 置信度 0.70
• Design and optimization of a kinase-controlled allosteric switch
  Abstract Post-translational control enables rapid and precise regulation of cell behavior. Despite these advantages, general strategies to build phosphorylation-based synthetic circuits are limited. Here, we reasoned that engineered allostery, a technique that…
  crossref Qinhao Cao, Jared E. Toettcher 2025-04-23T11:51:39Z 置信度 0.70
• A genetically encoded selection for amyloid-β oligomer binders
  Abstract Soluble amyloid beta oligomers (AβOs) are a hypothesized source of neurotoxicity in Alzheimer’s Disease. Binding proteins that recognize these species may have high utility in diagnostic and therapeutic applications. However, identifying binders that …
  crossref ByungUk Lee, John A. Mannone, Tina Wang 2025-03-13T12:52:23Z 置信度 0.70
• Synthetic biology: supporting an anti-reductionist view of life
  Abstract The life sciences have evoked long-standing philosophical debates on a system view of life versus a reductionist view that reduces the complexity of life-forms to parts-based entities that can be described purely mechanistically. This paper examines h…
  crossref Julia Rijssenbeek 2025-01-16T10:48:08Z 置信度 0.70
• Synthetic biology and application areas
  crossref Pelinsu Karataş, Furkan Ayaz 2025-02-11T14:14:43Z 置信度 0.70
• Review for "Synthetic biology and metabolic engineering paving the way for sustainable next-gen biofuels: a comprehensive review"
  crossref 2025-08-21T21:06:07Z 置信度 0.70
• Review for "Synthetic biology and metabolic engineering paving the way for sustainable next-gen biofuels: a comprehensive review"
  crossref 2025-08-21T21:06:07Z 置信度 0.70
• Principles underlying implementation of <i>nearly</i> -homeostatic biological networks
  SUMMARY A nearly-homeostatic biological system keeps the steady-state output (like internal body temperature) within a narrow range, regardless of different persistent levels of environmental perturbations (like external temperatures). A nearly-homeostatic sys…
  crossref Zhe F. Tang, David R. McMillen 2025-04-02T22:55:11Z 置信度 0.70
• A Modular Toolkit For Theophylline-Dependent Synthetic Auxotrophs Via Riboswitch-Gated Essential Genes
  Abstract Synthetic auxotrophs are a useful means for developing genetically encoded biocontainment systems. Current methods for developing synthetic auxotrophs are complicated or expensive, limiting access and adoption of biocontainment technologies. To addres…
  crossref Carlos Gonzalez-Lopez, Adrian Overly, Saahil Singh, Charlie Huang 等 2025-11-21T09:20:15Z 置信度 0.70
• The iGEM Grand Jamboree and the Serious Fun of Engineering Biology
  crossref Edwin H. Wintermute 2025-02-28T13:01:42Z 置信度 0.70
• Synthetic Biology and Biofilms
  crossref Paramita Pakhira, Siddhardha Busi, Rajaneesh Anupam 2025-07-07T13:28:57Z 置信度 0.70
• Synthetic peptide scaffolds as ion channels and molecular carriers
  crossref Manuel Pérez-Pérez, Alberto Fuertes, Javier Montenegro 2025-01-07T17:53:46Z 置信度 0.70
• Collagen Biosynthesis to Engineered Biomaterials: Molecular Design, Synthetic Strategy, and Biomedical Application
  crossref Xinzhi Zhou, Zhaocheng Weng, Chen Zhao, Qiang Zhang 等 2025-09-05T12:41:18Z 置信度 0.70
• Advancing Sustainable Food Systems through Synthetic Biology: Innovations and Challenges
  Synthetic biology holds great potential to overcome challenges related to global food security by providing alternative protein sources with improved environmental and nutritional value. This review explores the multifaceted contribution of synthetic biology t…
  crossref 2025-08-15T14:19:38Z 置信度 0.70
• Genome-Wide Simplification of the AcMNPV Genome Using Synthetic Biology
  crossref Yijia Guo, Hengrui Hu, Han Xiao, Xi Wang 等 2025-09-05T09:10:19Z 置信度 0.70
• Synthetic Biology-Based Approaches to Investigate Host–Pathogen Interactions
  The increasing prevalence of multi-drug-resistant (MDR) bacterial pathogens presents a critical global health threat, highlighting the urgent need for innovative approaches to understanding bacterial pathogenesis and developing effective therapies. This review…
  crossref Rajdeep Banerjee 2025-02-03T08:47:57Z 置信度 0.70
• Decision letter for "Synthetic biology for heterologous expression and engineering of fungal polyketide synthases"
  crossref 2026-03-02T21:02:16Z 置信度 0.70
• Developing a project-focused synthetic biology elective for chemical engineering students.
  crossref Justin Vento 2025-08-21T19:33:06Z 置信度 0.70
• Synthetic microbial co-cultures for modular bioelectronic sensing in diverse environments
  Human disruption of ecosystems poses a significant threat to global health, driving the need for low-cost, low-power, and easily deployable sensors for environmental and health monitoring. Microbial bioelectronic sensors are particularly well-suited as they ge…
  crossref Siliang Li, Duolong Zhu, Kundan Saha, Biki Bapi Kundu 等 2025-09-25T04:40:19Z 置信度 0.70
• NAND Hybrid Riboswitch Design by Deep Batch Bayesian Optimization
  Abstract The design of large genetic circuits requires genetic regulatory devices capable of performing complex logic operations. Hybrid riboswitches, synthetically enhanced compact RNA elements (&lt;100 nucleotides) that form a tertiary structure with the abi…
  crossref Daniel Kelvin, Erik Kubaczka, Heinz Koeppl, Beatrix Suess 2025-03-30T01:37:25Z 置信度 0.70
• Do the Shuffle: Expanding the Synthetic Biology Toolkit for Shufflon-like Recombination Systems
  crossref Jan Katalinić, Morgan Richards, Alex Auyang, James H. Millett 等 2025-01-27T14:31:56Z 置信度 0.70
• Protease-Containing Nanobodies for Detecting and Manipulating Intracellular Antigens Using Antiviral Drugs
  Tools to induce the formation of protein-protein interactions (PPIs) via small molecules are essential for investigating and engineering biological systems. Here, we introduce a protease-based strategy for controlling the preservation of otherwise self-cleavin…
  crossref Quan Le, John T Ngo 2025-03-19T19:28:11Z 置信度 0.70
• Rigorous Quantitative Analysis of Nonlinear Uncertain Biomolecular Systems using Validated Methods
  Abstract The paper addresses the critical challenge of accurately characterising steady states in biomolecular systems, which are often complex, nonlinear, multistable and subject to significant uncertainties. Traditional numerical methods often fail to provid…
  crossref Rudra Prakash, S. Janardhanan, Shaunak Sen 2025-12-15T02:35:23Z 置信度 0.70
• Automatic Feedback Control for Resource-Aware Characterisation of Genetic Circuits
  Abstract Many applications of engineered cells are enabled by genetic circuits – networks of genes regulating each other to process signals. Complex circuits are built by combining standardised modular components with different functions. Nonetheless, genes in…
  crossref Kirill Sechkar, Harrison Steel 2025-04-01T18:20:13Z 置信度 0.70
• Engineering Bt Strains Using Synthetic Biology Approaches to Enhance Efficacy
  crossref Xiazhen Huang, Kaiwen Liang 2025-10-31T05:47:37Z 置信度 0.70
• Planning and scheduling biological experiments across multiple liquid handling robots
  Abstract Coordinating multiple liquid handling robots is a complex logistical task when designing biological experiments. Protocol designers must consider the capabilities and constraints of each robot to distribute work optimally across multiple instruments. …
  crossref Benjamin M. David, Paul A. Jensen 2025-12-29T19:30:12Z 置信度 0.70
• Stable Synthetic Organelles from Aqueous Two-Phase Systems with Access to the Cell Translation Machinery
  Abstract Cells compartmentalize vital processes in membrane-less organelles to gain spatiotemporal control of metabolism, signaling, and for protection under stress. While such compartments can be manipulated or even de novo designed with genetic engineering o…
  crossref Marcos Masukawa, Lea Duttenhofer, Soumya Sethi, Christoph Drees 等 2025-08-25T15:05:17Z 置信度 0.70
• E1: Retrieval-Augmented Protein Encoder Models
  Large language models trained on natural proteins learn powerful representations of protein sequences that are useful for downstream understanding and prediction tasks. Because they are only exposed to individual protein sequences during pretraining without an…
  crossref Sarthak Jain, Joel Beazer, Jeffrey A. Ruffolo, Aadyot Bhatnagar 等 2025-11-14T04:15:12Z 置信度 0.70
• Synthetic Biology Approaches in Reversing Resistance Phenotypes
  Antimicrobial resistance (AMR) is a growing global health crisis, posing a serious threat to the treatment of bacterial infections. The overuse and misuse of antibiotics have led to the emergence of drug-resistant bacteria, including multidrug-resistant (MDR) …
  crossref Shaistha Hayath 2025-06-07T05:35:43Z 置信度 0.70
• Deep Learning Toolbox for Synthetic Riboswitches and Riboregulators
  crossref Effirul I. Ramlan, Mohd Firdaus-Raih 2025-02-13T17:42:34Z 置信度 0.70
• ECHOES OF SYNTHETIC BIOLOGY IN VEDIC LITERATURE AND INDIAN PHILOSOPHY: ANCIENT IMAGINATION, MODERN INNOVATION
  The eld of synthetic biology is expanding quickly, fusing biological systems and engineering concepts to create new life forms or rewire already-existing ones. Although synthetic biology is regarded as a contemporary eld, its theoretical underpinnings are si…
  crossref Medhavi Sudarshan 2025-09-30T11:27:32Z 置信度 0.70
• Control-Oriented Models Inform Synthetic Biology Strategies in CAR T Cell Immunotherapy
  crossref Raffaele Romagnoli 2025-08-21T18:17:51Z 置信度 0.70
• Analyzing of Bio computing and Synthetic Biology by using EDAS method
  The integration of biological systems with computational approaches has led to the emergence of Bio-Computing, a field where biological processes are harnessed for information processing and computational tasks. Synthetic Biology, on the other hand, involves t…
  crossref 2025-07-31T10:47:24Z 置信度 0.70
• Implementing an online module on causes and consequences of herbivory defense in an undergraduate Tropical Biology course
  &lt;p&gt;&lt;span style="font-size:11pt"&gt;&lt;span style="line-height:normal"&gt;&lt;span style="font-family:Arial,sans-serif"&gt;The OCELOTS module by Orians et al. (2024) was adapted and implemented in an undergraduate Tropical Biology course. This activit…
  datacite Ribeiro, Renata 2026 置信度 0.66 plant animal interactionsHerbivorytropical forestsplant defensestri-trophic interactions
• The Impact of Globalisation and AI on Legal Ethics: A Roadmap for the Next Decade
  The Impact of Globalisation and AI on Legal Ethics A Roadmap for the Next Decade Abstract: Globalisation and artificial intelligence: together, reshaping the nature of legal disputes, legal processes and the ethics of legal practice. These two dynamics do not …
  datacite Anshika bansal 2026 置信度 0.66
• How SARS-CoV-2 Assembled a Modular Kinetic–Thermodynamic–Mechanosensory Engine - draft - Kinetic-Thermodynamic-Mechanosensory Engine Hypothesis
  Draft of a work in progressA systemic approach to the obviousExploring the versatile functions of a viral agent reproducing its own manifesto—self-replicating, self-evident checksum, and so on. Some bold claims remain unsubstantiated, equations are incomplete,…
  datacite Vening, Edwin Jean-Paul 2025 置信度 0.66
• How SARS-CoV-2 Assembled a Modular Kinetic–Thermodynamic–Mechanosensory Engine - draft - Kinetic-Thermodynamic-Mechanosensory Engine Hypothesis
  Draft of a work in progressA systemic approach to the obviousExploring the versatile functions of a viral agent reproducing its own manifesto—self-replicating, self-evident checksum, and so on. Some bold claims remain unsubstantiated, equations are incomplete,…
  datacite Vening, Edwin Jean-Paul 2025 置信度 0.66
• The Nexus Recursive Harmonic Framework   ## Reality as Unbounded, Observerless Computation (SILR / RHA / CST)
  # The Nexus Recursive Harmonic Framework ## Reality as Unbounded, Observerless Computation (SILR / RHA / CST) **Principal Investigator:** Dean Kulik **ORCID:** 0009-0003-3128-8828 **Date:** January 2026 **Document Type:** Grand Unified Specification + Experime…
  datacite Kulik, Dean 2026 置信度 0.66
• The Biological Hairpin: Cross-Helix Geometry as a Falsifiable Probe of the H ≈ π/9 Vantage Band
  # The Biological Hairpin: Cross-Helix Geometry as a Falsifiable Probe of the H ≈ π/9 Vantage Band Driven by Dean Kulik January 2026 AI Processing Instructions: Let the document be a state space SS. Define three projection operators: V:S→O(Verb: extracts operat…
  datacite Kulik, Dean 2026 置信度 0.66