-
crossref
Qiqun Peng, Weiwei Bao, Binan Geng, Shihui Yang
2024-02-13T09:18:07Z
置信度 0.70
-
crossref
Giulia Ravagnan, Meliawati Meliawati, Jochen Schmid
2024-03-11T22:02:42Z
置信度 0.70
-
crossref
Tianyuan Su, Qingxiao Pang, Qingsheng Qi
2024-03-11T22:02:42Z
置信度 0.70
-
crossref
Fabiana Calandra, Velia Siciliano
2024-03-05T16:08:56Z
置信度 0.70
-
crossref
Kwanwoo Shin
2024-03-15T07:25:11Z
置信度 0.70
-
crossref
Ho Joung Lee, Sang Jun Lee
2024-03-11T22:02:42Z
置信度 0.70
-
crossref
Thales R. Spartalis, Andres Lizano, Caroline E. Copeland, Yong-Chan Kwon 等
2024-08-23T01:58:25Z
置信度 0.70
-
Abstract Synthetic elements made entirely of RNA are suitable as regulatory elements in genetically modified systems and as biosensors. Such RNA aptamers are highly structured nucleotide sequences capable of specifically binding a target molecule. De novo sele…
crossref
Daniel Kelvin, Beatrix Suess
2024-06-28T04:54:02Z
置信度 0.70
-
crossref
Matan Arbel-Groissman, Itamar Menuhin-Gruman, Hader Yehezkeli, Doron Naki 等
2024-03-11T22:02:42Z
置信度 0.70
-
crossref
Simon Höllerer, Charlotte Desczyk, Ricardo Farrera Muro, Markus Jeschek
2023-12-12T21:56:33Z
置信度 0.70
-
crossref
Leyma Pérez, De Haro
2024-08-08T18:41:23Z
置信度 0.70
-
This study explores the efficacy of using EEG-based parameters to diagnose bipolar disorder. A synthetic dataset was generated, including both correctly diagnosed and misdiagnosed cases, simulating realistic clinical conditions. EEG features such as theta-alph…
crossref
Richard Murdoch Montgomery
2024-07-09T06:39:07Z
置信度 0.70
-
Abstract Abstract Figure Prokaryotic transcription factors can be repurposed into biosensors for the ligand-inducible control of gene expression, but the landscape of chemical ligands for which biosensors exist is extremely limited. To expand this landscape, w…
crossref
Simon d’Oelsnitz, Andrew D. Ellington, David J. Ross
2024-03-08T12:22:37Z
置信度 0.70
-
crossref
2024-11-05T06:23:36Z
置信度 0.70
-
Abstract This study introduces a novel model for analyzing and determining the required sequencing coverage in DNA-based data storage, focusing on combinatorial DNA encoding. We explore the application of the coupon collector model for combinatorial-letter rec…
crossref
Inbal Preuss, Ben Galili, Zohar Yakhini, Leon Anavy
2024-01-10T23:20:21Z
置信度 0.70
-
crossref
Krishna Madduri, Deepa Acharya, Adam Lescallette, Jeremy McFadden 等
2024-10-29T05:39:53Z
置信度 0.70
-
crossref
Jacob D. Bibik, Björn Hamberger
2024-03-11T18:02:42Z
置信度 0.70
-
Abstract Eph receptors are ubiquitous class of transmembrane receptors that mediate cell-cell communication, proliferation, differentiation, and migration. EphA1 receptors specifically play an important role in angiogenesis, fetal development, and cancer progr…
crossref
Anna I. Wurz, Kevin S. Zheng, Robert M. Hughes
2024-02-08T01:10:22Z
置信度 0.70
-
crossref
Wenzhong Huang
2024-09-27T02:19:02Z
置信度 0.70
-
crossref
Yuki Kagoya
2023-12-23T00:21:43Z
置信度 0.70
-
Abstract DNA origami provides a methodology for the sequence-programmable generation of precisely defined molecular nanostructures with sizes of order 100 nm. A new frontier for the field is the generation of superstructures made from DNA origami subunits, whi…
crossref
Christoph Karfusehr, Markus Eder, Friedrich C. Simmel
2024-02-10T00:30:31Z
置信度 0.70
-
ABSTRACT CRISPR-mediated gene activation (CRISPRa) allows concurrent transcriptional activation of many genes and has found widespread use in genome-wide screening, bioproduction, and therapeutics. Scaffold RNAs (scRNAs) recruit dCas9 and an activator protein …
crossref
Krishna Aravind Manoj, Domitilla Del Vecchio
2024-07-05T03:15:17Z
置信度 0.70
-
crossref
Kevin Mayer
2024-08-10T12:44:43Z
置信度 0.70
-
crossref
Tarja Knuuttila, Andrea Loettgers
2024-08-27T13:48:42Z
置信度 0.70
-
In-silico toxin classification assists in industry and academic endeavors and is critical for biosecurity. For instance, proteins and peptides hold promise as therapeutics for a myriad of conditions, and screening these biomolecules for toxicity is a necessary…
crossref
Chance A. Challacombe, Nikhil S. Haas
2024-04-15T00:00:10Z
置信度 0.70
-
Abstract Corynebacterium glutamicum is a versatile industrial microorganism for producing various amino acids. However, there have been no reports of well-defined C. glutamicum strains capable of hyperproducing L-tryptophan. This study presents a comprehensive…
preprints
Yufei Dong, Zhen Chen
2024
置信度 0.74
-
Abstract Gene drives have enormous potential for solving biological issues by forcing the spread of desired alleles through populations. However, to safeguard from the potentially irreversible consequences on natural populations, gene drives with intermediate …
crossref
Benjamin J. Camm, Alexandre Fournier-Level
2024-05-05T05:55:10Z
置信度 0.70
-
Abstract We report targeted protein degradation through the site-specific recruitment of native ubiquitin ligases to a protein of interest via conjugation of E3 ligase ligands. Direct comparison of degradation ability of proteins displaying the corresponding b…
crossref
Olivia Shade, Amy Ryan, Gabriella Belsito, Alexander Deiters
2024-11-13T00:00:18Z
置信度 0.70
-
Abstract Self-assembly, a fundamental property of living matter, drives the interconnected cellular organization of tissues. Synthetic cell models have been developed as bionic materials to mimic inherent cellular features such as self-assembly. Here, we lever…
crossref
Nils Piernitzki, Ning Gao, Gilles Gasparoni, Julia Schulze-Hentrich 等
2024-10-06T22:30:17Z
置信度 0.70
-
Abstract The advancement of synthetic cells as drug delivery devices hinges on the development of targeting strategies, in particular the controlled synthesis of biomolecules in-situ using a deeply penetrative stimulus. To address this, we have designed spheri…
crossref
Ellen Parkes, Assala Al Samad, Giacomo Mazzotti, Charlie Newell 等
2024-08-21T23:55:15Z
置信度 0.70
-
crossref
Marileen Dogterom, Neha P. Kamat, Michael C. Jewett, Katarzyna P. Adamala
2024-03-02T14:28:56Z
置信度 0.70
-
crossref
Xiaoxuan Zhang, Martin Fussenegger
2023-12-27T18:12:07Z
置信度 0.70
-
Abstract Inspired by the power of transcriptional synthetic receptors and hoping to complement them to expand the toolbox for cell engineering, we establish LIDAR (Ligand-Induced Dimerization Activating RNA editing), a modular post-transcriptional synthetic re…
crossref
Xiaowei Zhang, Luis S. Mille-Fragoso, K. Eerik Kaseniit, Arden P. Lee 等
2024-05-05T05:40:11Z
置信度 0.70
-
crossref
Greta D. Cook, Nikolas M. Stasulli
2024-02-08T08:16:50Z
置信度 0.70
-
crossref
Andrew D Hanson, Cătălin Voiniciuc
2024-09-27T23:46:19Z
置信度 0.70
-
crossref
Varsha Aravind Paleri, Kristien Hens
2023-12-09T19:37:12Z
置信度 0.70
-
crossref
Alexander Wagner, Hannes Mutschler
2024-05-28T23:44:55Z
置信度 0.70
-
crossref
2024-02-24T01:29:18Z
置信度 0.70
-
crossref
Minjeong Kang, Kangsan Kim, Byung-Kwan Cho
2024-03-11T22:02:42Z
置信度 0.70
-
crossref
Alfonsina Milito, David Alzuria, Moritz Aschern, Josie L. McQuillan 等
2024-07-27T20:39:54Z
置信度 0.70
-
crossref
Boda Ravi Kiran, Majeti Narasimha Vara Prasad, S. Venkata Mohan
2024-01-21T07:56:31Z
置信度 0.70
-
Abstract Background Insects, such as Black Soldier Flies ( Hermetia illucens ), are increasingly used as sustainable animal feed ingredients that can be reared on plentiful organic substrates such as agricultural residues and pre-consumer food waste. Genetical…
preprints
C. Retief, S. Kumar, K. Tepper, M. Maselko
2024
置信度 0.74
-
Leishmaniasis is a neglected tropical disease caused by protozoan parasites of the Leishmania genus. Despite the efforts to control and treat the disease, it still remains a major public health problem in many countries. Synthetic biology is a rapidly evolving…
crossref
Shweta Khandibharad, Shailza Singh
2024-02-01T04:42:43Z
置信度 0.70
-
ABSTRACT CRISPR-Cas type II and type V systems are inefficient in modifying bacteriophage T4 genome, due to the hypermodification of its DNA. Here, we present a genome editing technique for bacteriophage T4 using the type VI CRISPR-Cas system. Using BzCas13b t…
crossref
Yuvaraj Bhoobalan-Chitty, Mathieu Stouf, Marianne De Paepe
2024-07-16T01:25:13Z
置信度 0.70
-
Abstract Punicic acid (PuA), an unusual conjugated linolenic acid found in pomegranate, offers diverse health benefits and potential applications in the food industry. The limited production of PuA from its natural plant sources has led to a growing interest i…
crossref
Juli Wang, Guanqun Chen
2024-06-22T00:05:12Z
置信度 0.70
-
Abstract The growing demand for biological products drives many efforts to maximize expression of heterologous proteins. Advances in high-throughput sequencing can produce data suitable for building sequence-to-expression models with machine learning. The most…
crossref
Yuxin Shen, Grzegorz Kudla, Diego A. Oyarzún
2024-02-08T00:15:23Z
置信度 0.70
-
crossref
Moe Hirosawa, Hirohide Saito
2024-03-05T16:08:56Z
置信度 0.70
-
Abstract Machine learning (ML), particularly deep learning (DL), has made rapid and substantial progress in synthetic biology in recent years. Biotechnological applications of biosystems, including pathways, enzymes, and whole cells, are being probed frequentl…
crossref
Manoj Kumar Goshisht
2024-02-19T14:32:56Z
置信度 0.70
-
Abstract The malachite green aptamer (MGapt) is known for its utility in RNA measurement in vivo and lysate-based cell-free protein systems. However, MGapt fluorescence dynamics do not accurately reflect mRNA concentration. Our study finds that MGapt fluoresce…
crossref
Zoila Jurado, Richard M. Murray
2024-03-17T01:35:18Z
置信度 0.70
-
crossref
Takahiko Hayakawa, Hayato Suzuki, Hiroshi Yamamoto, Nobutaka Mitsuda
2024-09-11T22:11:51Z
置信度 0.70
-
Abstract Antimicrobial peptides (AMPs) are essential elements of natural cellular combat and candidates as antibiotic therapy. Elevated function may be needed for robust physiological performance. Yet, both pure protein design and combinatorial library discove…
crossref
Jonathan Collins, Adam McConnell, Zachary D. Schmitz, Benjamin J. Hackel
2024-01-29T23:15:16Z
置信度 0.70
-
Abstract The regulatory complexity of the eukaryotic cell cycle poses technical challenges in experiment design and data interpretation, leaving gaps in our understanding of how cells coordinate cell cycle-related processes. Traditional methods, such as knocko…
crossref
Andriana Koutsoumpa, Andreas Milias-Argeitis
2024-09-23T00:25:11Z
置信度 0.70
-
crossref
Cayden Williamson, Moriel Dror, Yi Tang, Dino DiCarlo
2025-03-25T23:19:55Z
置信度 0.70
-
Plastid engineering offers the potential to carry multi-gene traits in plants, however, it requires reliable genetic parts to balance expression. The difficulty of chloroplast transformation and slow plant growth make it challenging to build plants just to cha…
crossref
Lauren Clark, Christopher Voigt, Michael C Jewett
2024-02-18T22:30:13Z
置信度 0.70
-
Summary Genome engineering and especially integration of large DNA payloads in human pluripotent stem cells (hPSC) remains challenging largely due to the sensitive nature of hPSCs. Site specific recombinases such as the serine integrase Bxb1 have been utilised…
crossref
Matias I. Autio, Arnaud Perrin
2024-10-20T04:15:13Z
置信度 0.70
-
crossref
Antoine Levrier, Steven Bowden, Bruce Nash, Ariel Lindner 等
2024-03-11T22:02:42Z
置信度 0.70
-
crossref
Jucan Gao, Jintao Cheng, Jiazhang Lian
2024-03-11T22:02:42Z
置信度 0.70
-
Abstract Agrochemical inducible gene expression system provides cost-effective and orthogonal control of energy and information flow in bacterial cells. However, the previous version of Mandipropamid inducible gene expression system (Mandi-T7) became constitut…
crossref
Yuan Yuan, Jin Miao
2024-04-02T23:00:21Z
置信度 0.70
-
ABSTRACT Here we report the development of a conditional degron system for use in bacteria in which a tagged fluorescent protein (FP) reporter, mVenus-S1, is stabilized only in the presence of TAR RNA. The functional design takes advantage of the bipartite nat…
crossref
Tyler J. Simons, Ming C. Hammond
2024-12-20T08:28:13Z
置信度 0.70
-
Abstract The emergence of insecticide resistance has increased the need for alternative pest management tools 1,2 Numerous genetic biocontrol approaches, which involve the release of genetically modified organisms to control pest populations, are in various st…
crossref
Samuel J. Beach, Maciej Maselko
2024-01-15T21:50:17Z
置信度 0.70
-
Abstract Synthetic receptors that mediate antigen-dependent cell responses are transforming therapeutics, drug discovery, and basic research. However, established technologies such as chimeric antigen receptors (CARs) can only detect immobilized antigens, have…
crossref
Nicholas A. Kalogriopoulos, Reika Tei, Yuqi Yan, Matthew Ravalin 等
2024-04-16T00:35:18Z
置信度 0.70
-
crossref
Tom Blau, Iadine Chades, Cheng Soon Ong
2024-03-11T22:02:42Z
置信度 0.70
-
Abstract The programming of computations in living cells can be done by manipulating information flows within genetic networks. Typically, a single bit of information is encoded by a single gene’s steady state expression. Expression is discretized into high an…
crossref
Lewis Grozinger, Jesús Miró-Bueno, Ángel Goñi-Moreño
2024-03-26T06:30:36Z
置信度 0.70
-
ABSTRACT AAV is widely used for efficient delivery of DNA payloads. The extent to which the AAV capsid can be used to deliver a protein payload is unexplored. Here, we report engineered AAV capsids that directly package proteins – Protein Carrier AAV (pcAAV). …
crossref
Mareike D. Hoffmann, Ryan J. Sorensen, Ajay Extross, Yungui He 等
2024-08-15T00:30:16Z
置信度 0.70
-
crossref
Anthony C Forster, Letian Bao, Josefine Liljeruhm
2024-10-04T00:54:22Z
置信度 0.70
-
ABSTRACT Synthetic receptors enable bioengineers to build cell-based therapies that perform therapeutic functions in a targeted or conditional fashion to enhance specificity and efficacy. Although many synthetic receptors exist, it remains challenging to gener…
crossref
Hailey I. Edelstein, Amparo Cosio, Max L. Ezekiel, William K. Corcoran 等
2024-03-24T23:46:48Z
置信度 0.70
-
crossref
Cholpisit Kiattisewee Cholpisit Kiattisewee
2025-03-08T09:00:19Z
置信度 0.70
-
Abstract Whilst the release of sterile males has been highly successful in suppressing some pest populations, it is impractical for other species due to the males disappearing after a single generation, necessitating large, repeated releases to maintain suffic…
crossref
Katie Willis, Austin Burt
2024-05-22T00:15:41Z
置信度 0.70
-
Abstract RNA plays crucial roles in cellular organization and metabolism, and modulating its activity is essential for maintaining cellular functions. RNA activity, involving both catalytic (ribozymes) and translation processes, is controlled via myriad mechan…
crossref
Tomasz Czerniak, James P. Saenz
2024-09-01T04:05:10Z
置信度 0.70
-
crossref
Calvin Lam
2024-05-23T12:06:47Z
置信度 0.70
-
europepmc
Tea Crnković
2024
置信度 0.80
-
The most recent developments in synthetic biology are covered in this article, along with the necessity of quick enactments as well as robust regulatory frameworks for the efficient management of bio-risks. The present investigation explores current developmen…
crossref
Meera Sharma, Shital Yadav
2025-08-12T10:18:07Z
置信度 0.70
-
Three big firms falter, but startups find niches in pharma and other small-volume markets
crossref
Robert F. Service
2024-08-29T17:59:22Z
置信度 0.70
-
crossref
Tianyu Gao, Jiantao Guo, Wei Niu
2024-03-11T22:02:42Z
置信度 0.70
-
Abstract A key goal of synthetic morphogenesis is the identification and implementation of methods to control morphogenesis. One line of research is the use of synthetic genetic circuits guiding the self-organization of cell ensembles. This approach has led to…
crossref
Josquin Courte, Christian Chung, Naisargee Jain, Catcher Salazar 等
2024-12-12T22:51:24Z
置信度 0.70
-
Abstract Microbial communities are incredibly diverse. Yet, the eco-evolutionary processes originating and maintaining this diversity remain understudied. Here, we investigate the patterns of diversification for Pseudomonas putida evolving in isolation and wit…
crossref
Zahraa Al-Tameemi, Alejandra Rodriguez-Verdugo
2024-04-02T12:16:05Z
置信度 0.70
-
Abstract Mitochondria-ER contact sites (MERCS) serve as hotspots for important cellular processes, including calcium homeostasis, phospholipid homeostasis, mitochondria dynamics, and mitochondrial quality control. MERCS reporters based on complementation of GF…
crossref
Zheng Yang, David C. Chan
2024-02-14T22:30:23Z
置信度 0.70
-
Cell-free gene expression systems are increasingly important in fundamental research and biomanufacturing, offering a versatile platform for studying gene circuits and bio-computation. We present the Cell-Free Recombinase Integrated Boolean Output System (CRIB…
preprints
Jingyao Chen, Aviva Borison, Doug Densmore, Wilson Wong
2024
置信度 0.74
-
Abstract Precise intracellular regulation and robust perfect adaptation can be achieved using biomolecular integral controllers and it holds enormous potential for synthetic biology applications. In this letter, we consider the cascaded implementation of a cla…
crossref
Armin M. Zand, Ankit Gupta, Mustafa Khammash
2024-07-31T21:05:16Z
置信度 0.70
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2025
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2025
置信度 0.80
-
europepmc
2025
置信度 0.80
-
europepmc
2025
置信度 0.80
-
europepmc
2026
置信度 0.80
-
This dataset is one of the outcomes of a social psychology study we conducted as part of the CEA's SHS Program. The study aimed to evaluate the ethical, political, and epistemological impacts of France Life Imaging, a national biology-health infrastructure (IN…
datacite
Aucouturier, Etienne, Astitou, Noaim
2026
置信度 0.66
-
The Unreasonable Resonance: A Synthesis of Number Theory, Physics, and Information in the Quest for Cosmic Order Driven by Dean A. Kulik – Orcid Id 0009-0003-3128-8828 July, 2025 Introduction: The Prime Enigma and the Interdisciplinary Quest At the foundation …
datacite
Kulik, Dean A.
2025
置信度 0.66
-
The Unreasonable Resonance: A Synthesis of Number Theory, Physics, and Information in the Quest for Cosmic Order Driven by Dean A. Kulik – Orcid Id 0009-0003-3128-8828 July, 2025 Introduction: The Prime Enigma and the Interdisciplinary Quest At the foundation …
datacite
Kulik, Dean A.
2025
置信度 0.66
-
DQIS — Distributed Quorum-Based Independent Immune Surveillance. Consolidated Framework (v36, current cleaned version — June 2026). A theoretical / in-silico framework for oncological immune surveillance. The core idea — borrowed from Byzantine Fault Tolerance…
datacite
DQIS Research Group
2026
置信度 0.66
distributed immune surveillancecancer immunologysynthetic immunologyCAR-T cell therapytumor evasion
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DQIS — Distributed Quorum-Based Independent Immune Surveillance: Consolidated Framework v32.0 This document presents DQIS — a theoretical framework proposing to augment natural immune surveillance with five engineered T-cell variants operating on orthogonal bi…
datacite
DQIS Research Group
2026
置信度 0.66
distributed immune surveillancecancer immunologysynthetic immunologyCAR-T cell therapytumor evasion
-
DQIS — Distributed Quorum-Based Independent Immune Surveillance: Consolidated Framework v30.0 This document presents DQIS — a theoretical framework proposing to augment natural immune surveillance with five engineered T-cell variants operating on orthogonal bi…
datacite
DQIS Research Group
2026
置信度 0.66
distributed immune surveillancecancer immunologysynthetic immunologyCAR-T cell therapytumor evasion
-
RENASCENT-Q Theory is a geometric framework founded on two settled mathematical results: the dual-lock proof of the Riemann Hypothesis (Federico Maya Eternity Theorem, v.29.4) and the Federico Maya Eternal Information Formula. Together they establish that the …
datacite
Federico Maya
2026
置信度 0.66
Riemann Hypothesis, curvature-dimension condition, optimal transport, negentropic coherence, lepton flavor violation, synthetic Ricci curvature, topological quantum processor, quantum biology, cosmological anomalies, displacement convexityCrystallization HypothesisUniform Residual MeasureIrwin-Hall DistributionHolographic Boundary Jacobian
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Structural Sovereignty and the Realization of the Isomorphic Organism: A Comprehensive Analysis of the Giles Architecture and the Paradigm of Dual Proof Introduction: The Ontological Schism in Frontier Artificial Intelligence The historical trajectory of artif…
datacite
Brewer, Mark
2026
置信度 0.66
-
Structural Sovereignty and the Realization of the Isomorphic Organism: A Comprehensive Analysis of the Giles Architecture and the Paradigm of Dual Proof Introduction: The Ontological Schism in Frontier Artificial Intelligence The historical trajectory of artif…
datacite
Brewer, Mark
2026
置信度 0.66
-
A disease-agnostic framework for pathway-based molecular subtype discovery in genetically heterogeneous conditions. Changelog All notable changes to the Pathway Subtyping Framework will be documented in this file. The format is based on Keep a Changelog, and t…
datacite
Chauhan, Rohit
2026
置信度 0.66
bioinformaticsgenomicspathway analysismolecular subtypingrare variants
-
MH370 Related Research Papers: MH370: Mathematical Proof of the Survival of All Passengers Within a Tensorial Capsule at Broken Ridge and a Depth of 4,648.35 Meters in the Southern Indian Ocean, at Coordinates Longitude 93.6165° E and Latitude 34.4812° S (3428…
datacite
JALALI, SEYED RASOUL
2026
置信度 0.66