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• Context-Aware Synthetic Promoter Design Using Neural Networks Enables Rewiring of Eukaryotic Transcriptional Networks
  preprints 2025 置信度 0.74
• From Editing Genes to Orchestrating Networks: CRISPR and the Future of Precision Oncology
  preprints 2025 置信度 0.74
• Generating Bounded Linear Temporal Logic in Systems Biology with Large Language Models
  preprints 2025 置信度 0.74
• Magneto-Photonic Gene Circuit for Minimally Invasive Control of Gene Expression in Mammalian Cells
  ABSTRACT Precise control of gene expression is one of the fundamental goals of synthetic biology. Whether the objective is to modify endogenous cellular function or induce the expression of molecules for diagnostic and therapeutic purposes, gene regulation rem…
  preprints 2025 置信度 0.74
• Generative design and construction of functional plasmids with a DNA language model
  preprints 2025 置信度 0.74
• Chemical modulation of chloroplast de- and re-differentiation reveals a role for the SAL1-PAP retrograde pathway in facilitating plastid transitions
  preprints 2025 置信度 0.74
• Design of post-translational, ligand-controlled inverters and switches
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• Ligify 2.0: A web server for predicted small molecule biosensors
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• RNA Aptamers and Epitranscriptomics: Charting Unexplored Territories in RNA Biology
  preprints 2025 置信度 0.74
• Design principles of neuromorphic computing using genetic circuits
  Abstract Cells have evolved to sense a wide range of input combinations and integrate those signals through signaling pathways to produce context-specific responses, such as differentiation, cell-type specification, and patterning. To replicate this informatio…
  preprints Frank Britto Bisso, Durga Shree, Yinan Zhu, Christian Cuba Samaniego 2025 置信度 0.74
• Mirror Life: Chirality in Biology and the Quest for a “Looking-Glass” Organism
  preprints 2025 置信度 0.74
• Costs and impacts of vaccine preparedness investments for SARS-X pandemics
  preprints 2026 置信度 0.74
• Generative design of antibody Fc-variants with synthetic and programmable functional profiles
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• Microscopic PhotoSelection (MiPS) of single cells in mother machine microfluidic devices
  preprints 2025 置信度 0.74
• Transplastomic Biofactory for the Production of Functional Human α-Lactalbumin for Nutritional and Therapeutic Applications
  preprints 2025 置信度 0.74
• Rational Development of a Ligand for Theophylline Riboswitch Aptamer Expands Its Regulatory Dynamic Range in Prokaryotic and Eukaryotic Systems
  preprints 2025 置信度 0.74
• Iterative and modular expression of <i>Botryococcus braunii</i> genes enhances isoprenoid production in the diatom <i>Phaeodactylum tricornutum</i>
  preprints 2025 置信度 0.74
• Tryptophan Chemistry Driven by a Widespread Cytochrome P422 Enzyme Family
  preprints 2025 置信度 0.74
• Overriding bioprocess perturbations with a cell–machine interface for reliable microbial stress-response control
  Controlling cell population dynamics and phenotypic diversification is a key objective in systems and synthetic biology, particularly for ensuring uniform responses from engineered gene circuits. While cell-machine interfaces have been employed to modulate hos…
  preprints 2025 置信度 0.74
• Modeling Oxidative Stress–Linked Telogen Effluvium: A Monte Carlo Simulation Using Published Trichoscopy Norms and Cannabis Exposure Distributions
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• A Thermodynamic Framework for Chromatin Structure and Function
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• Pesticide Degradation by Soil Bacteria: Mechanisms, Bioremediation Strategies, and Implications for Sustainable Agriculture
  preprints 2025 置信度 0.74
• Modeling Oxidative Stress–Linked Telogen Effluvium: A Monte Carlo Simulation Using Published Trichoscopy Norms and Cannabis Exposure Distributions
  preprints 2025 置信度 0.74
• DNA branch migration across intact membranes powers an inside-out GPCR analog for lysis-free detection of intracellular RNA with on-membrane amplification
  preprints 2025 置信度 0.74
• SimuScan: Label-Free Deep Learning for Autonomous AFM
  preprints 2025 置信度 0.74
• Virus Meets Chemistry: Chemical, Genomic, and Structural Strategies for Targeted Bacteriophage Therapeutics
  preprints 2025 置信度 0.74
• Association Studies of Phage Metagenomes from Aquatic Environment Identify Known and Potentially New Key Players in the 2,6-Diaminopurine Biosynthesis Pathway
  preprints 2025 置信度 0.74
• Engineering a Covalent Linkage into a Dimeric <i>De Novo</i> Enzyme Reveals a Novel Life-Sustaining Mechanism
  preprints 2025 置信度 0.74
• Comprehensive Advances on Probiotic-Fermented Medicine and Food Homology
  preprints 2025 置信度 0.74
• Computational Cellular Programming: In Silico Modeling of Direct and Reprogrammed Hepatic Lineage Induction via Gene Regulatory and Functional Dynamics
  preprints 2025 置信度 0.74
• Yorzoi: Predicting RNA-seq coverage from DNA sequence in yeast
  preprints 2025 置信度 0.74
• Fluorescent Biosensor-Guided Engineering of Enzyme Cascades for Electrochemical Applications
  preprints 2025 置信度 0.74
• Integrated microdroplet workflow for high-throughput cell-free transcription in double emulsion picoreactors
  preprints 2025 置信度 0.74
• The Dayhoff Atlas: scaling sequence diversity for improved protein generation
  preprints 2025 置信度 0.74
• Bibliometric analysis and network visualisation for horizon scanning of bioengineering innovations
  preprints 2026 置信度 0.74
• Dimensions, stability, and deformability of DOPC-cholesterol giant unilamellar vesicles formed by droplet transfer
  preprints 2025 置信度 0.74
• Optimizing Bispecific Antibody Expression via Multi-Omics Analysis and Vector Redesign
  preprints 2025 置信度 0.74
• Quantification of Cholesterol Incorporation in Giant Unilamellar Vesicles Produced by a Modified cDICE Method
  preprints 2025 置信度 0.74
• In-Cell Synthesis of <i>N</i> ^ε -acetyl-L-lysine for Facile Protein Acetylation
  preprints 2025 置信度 0.74
• Transforming a Fragile Protein Helix into an Ultrastable Scaffold via a Hierarchical AI and Chemistry Framework
  preprints 2025 置信度 0.74
• iFLinkC-EZ: A scalable and automatable method for the assembly of complex fusion proteins and multi-gene expression constructs based on the iFLinkC framework
  Standardized methods for the assembly of DNA constructs have become indispensable in synthetic biology, biotechnology and basic research. The majority of frameworks – most prominently based on Golden Gate – have been developed and optimized for the assembly of…
  preprints 2025 置信度 0.74
• Adeno-associated viruses (AAVs) induce dose-dependent neonatal ventriculomegaly following intracerebroventricular administration
  preprints 2025 置信度 0.74
• Escherichia coli in Molecular Biology and Biotechnology
  preprints 2025 置信度 0.74
• Cell-free systems enable mechanistic characterization of genetically encoded RNA strand exchange circuits for programmable protein expression
  Nucleic acid circuits are powerful tools for programming biology, but the design principles for operating these circuits in complex cellular environments remain poorly understood compared to simple in vitro settings. Cell-free expression systems (CFES) are uni…
  preprints 2025 置信度 0.74
• StrucTrace: Fourier Watermarking for Traceable Bio-molecular Assets
  preprints 2025 置信度 0.74
• Microcompartments in archaeal ancestors of eukaryotes: a bioenergetic engine that could have fuelled eukaryogenesis
  preprints 2025 置信度 0.74
• Advancing Codon Language Modeling with Synonymous Codon Constrained Masking
  preprints 2025 置信度 0.74
• Engineered GO-Based Hydrogels for Controlled Hyaluronic Acid Release in Knee Osteoarthritis Treatment
  preprints 2025 置信度 0.74
• Functional genomics in a microbe that degrades and metabolizes PET plastic
  preprints 2025 置信度 0.74
• Unraveling Rare Codon Bias in Actinomycetota: Lineage-Specific and 5’ Terminal Enrichment Across 1936 Genomes
  preprints 2025 置信度 0.74
• Oscillatory Dynamics in Paclitaxel-Proteinoid Networks
  preprints 2025 置信度 0.74
• PRINTS, a tool for subcellular protein and organelle translocation and its application in screening LLPS disrupting peptides
  preprints 2025 置信度 0.74
• GHZ-Calibrated Quantum–Geometry for Skin Repair: Entropy-Guided Pharmacophoric-ODEs with ΔSASA-Energetics for Fibrocyte-Centric Designs
  preprints 2025 置信度 0.74
• A membrane-driven biochemical oscillator tunable by the volume to surface area ratio
  preprints 2025 置信度 0.74
• Secret life of prophages: template-directed synthesis of DNA superstructures via prophage activation and rolling circle replication in bacterial biofilms
  preprints 2025 置信度 0.74
• Deep Learning for RNA Secondary Structure Determination: Gauging Generalizability and Broadening the Scope of Traditional Methods
  preprints 2025 置信度 0.74
• Overcoming the eIF2α Brake in Human Cell-Derived Translation Systems
  preprints 2025 置信度 0.74
• A programmable mRNA platform for miRNA detection via miRNA-mRNA ₂ triplex-mediated ribosomal frameshifting
  ABSTRACT Programmed −1 ribosomal frameshifting (−1 PRF) is a recoding mechanism utilized by viruses to expand their coding capacity and modulate the stoichiometric ratio of −1 frame and 0 frame translation products. The stability of mRNA secondary structure at…
  preprints 2025 置信度 0.74
• F²-CommNet: Fourier–Fractional Neural Networks with Lyapunov Stability Guarantees for Hallucination-Resistant Community Detection
  preprints 2025 置信度 0.74
• A Systems Biology Approach to Dynamic Heat Shock Response: Modeling Gradual and Acute Stress Adaptation
  preprints 2025 置信度 0.74
• Shared and distinct sequence-function signatures define different modes of human TpoR activation
  preprints 2025 置信度 0.74
• Flux modelling analysis reveals the metabolic impact of cryptic plasmids and environmental conditions in probiotic <i>Escherichia coli</i> Nissle 1917
  preprints 2025 置信度 0.74
• PHYCUT: Scalable multiplex CRISPR/Cas9 editing for genome engineering in the diatom <i>Phaeodactylum tricornutum</i>
  preprints 2025 置信度 0.74
• Temperature-Dependent Recombinase-Based Genetic Circuits
  Temperature offers a simple yet powerful signal to program cellular behavior. Here, we engineered and characterized a set of temperature-dependent genetic circuits that integrate RNA thermometers with site-specific DNA recombinases to achieve precise, irrevers…
  preprints 2025 置信度 0.74
• DNA Framework Nanoreactor for Programmable Membrane Fusion
  preprints 2025 置信度 0.74
• Origins of Life: The Possible and the Actual
  preprints 2025 置信度 0.74
• Generative inverse design of RNA structure and function with gRNAde
  preprints 2025 置信度 0.74
• SynAuto-X: A Programmable CRISPR-dCas9 Circuit for Precision Inflammation Control in Autoimmune Disorders
  preprints 2025 置信度 0.74
• <i>Streptomyces</i> Autoregulator Biosensors from Natural Product Cluster-Situated Regulators
  The soil dwelling bacteria Streptomyces is an abundant producer of numerous anticancer, antifungal, and antibiotic compounds (i.e. Natural Products, NPs). The sophisticated cellular machinery required to produce NPs is frequently regulated by quorum-sensing sy…
  preprints 2025 置信度 0.74
• Cryo-EM Structures of Methanogenic Schizorhodopsins Reveal Divergent Strategies for Proton Transport and Thermal Adaptation
  preprints 2025 置信度 0.74
• Leveraging FracMinHash Containment for Genomic <i>d</i> _<i>N</i> / <i>d</i> _<i>S</i>
  preprints 2025 置信度 0.74
• Self-similar Sequences Yield Higher Protein Expression in a Squid Ring Teeth Protein Library
  preprints 2025 置信度 0.74
• The Coli Toolkit (CTK): An extension of the modular Yeast Toolkit for use in <i>E. coli</i>
  Genetic circuits are a cornerstone of synthetic biology, enabling programmable control of cellular behavior for applications in health, sustainability, and biotechnology. While Genetic Design Automation (GDA) tools have optimized and streamlined the design of …
  preprints 2025 置信度 0.74
• Evaluation of computational tools for predicting CRISPR gRNA on-target efficiency in plants
  preprints 2025 置信度 0.74
• A screen for synthetic genetic interactions with the Saccharomyces cerevisiae hrq1ΔN allele
  preprints 2025 置信度 0.74
• De novo design of cysteine proteases
  preprints 2025 置信度 0.74
• Exploration and evaluation of novel restriction-modification systems in the edible, filamentous cyanobacterium Arthrospira platensis NIES-39
  preprints 2025 置信度 0.74
• High-resolution mapping of human RNA polymerase III reveals transcription termination as a rate-limiting step
  preprints 2025 置信度 0.74
• Synthetic and Functional Engineering of Bacteriophages: Approaches for Tailored Bactericidal, Diagnostic, and Delivery Platforms
  preprints 2025 置信度 0.74
• Adaptative and ancient co-evolution of integrons with <i>Xanthomonas</i> genomes
  preprints 2025 置信度 0.74
• Enabling regiospecific di-halogenation in one-pot reactions using an engineered single-component flavin-dependent tryptophan halogenase
  preprints 2025 置信度 0.74
• Amide Synthesis via Molecular Shuffling of Carboxylic Acids
  preprints 2025 置信度 0.74
• A Co-Evolutionary Multi-Objective Framework for Joint Topology and Parameter Discovery in Gene Regulatory Networks
  preprints 2025 置信度 0.74
• Design and Implementation of an Open-Access Arsenic Biosensor
  preprints 2025 置信度 0.74
• Genetic Engineering with Quantum Circuits: creating codes and studying BioBloQu genetic elements
  Quantum biology is an emergent field that investigates quantum-mechanical phenomena, such as superposition, tunneling, and entanglement, in the context of data manipulation from living systems. The exploration and engineering of nucleotide sequences rely on qu…
  preprints 2025 置信度 0.74
• A pathway-informed mutual exclusivity framework to detect genetic interactions in pediatric cancer
  preprints 2025 置信度 0.74
• Computational Approaches in Chemical Space Exploration for Carbon Fixation Pathways
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• Causes and consequences of experimental variation in <i>Nicotiana benthamiana</i> transient expression
  preprints 2025 置信度 0.74
• STAMPS: Signal-peptide Transformer for Augmenting Mammalian Protein Secretion
  While secretion plays a key role in the diverse applications of cell engineering, to date only a handful of mammalian signal peptides have been characterised in depth and systematic efforts to build novel variants remain sporadic. We present STAMPS (Signal-pep…
  preprints 2025 置信度 0.74
• BAR-CAT: Targeted Recovery of Synthetic Genes via Barcode-Directed CRISPR-dCas9 Enrichment
  Abstract Modern gene-synthesis platforms let us probe protein function and genome biology at unprecedented scale. Yet in large, diverse gene libraries the proportion of error-free constructs decreases with length due to the propagation of oligo synthesis error…
  preprints Natanya K. Villegas, Mindy H. Tran, Abigail Keller, Calin Plesa 2025 置信度 0.74
• Potentials of RNA Biosensors in Developmental Biology
  preprints 2025 置信度 0.74
• Disentangling the cost of gene expression
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• DNA Flipping as Facile Mechanism for Transmembrane Signaling in Synthetic Cells
  preprints 2025 置信度 0.74
• An experimentally verified mechanistic model for predicting quorum sensing-based switches
  Abstract Quorum sensing-based genetic circuits are gaining traction in synthetic biology as they link population-level behaviour to individual cell responses. However, tuning these circuits remains challenging due to complex dynamics, particularly during the ‘…
  preprints De Baets Jasmine, De Paepe Brecht, De Mey Marjan 2025 置信度 0.74
• Let there be multifunctionality: Uncovering the criticality zoo of the AC-DC genetic circuit
  Gene regulatory networks (GRNs) govern processes such as cell fate, patterning, and adaptation. While multistability and oscillations are both common GRN dynamics in cell biology, they are typically studied and engineered in isolation. Here, we challenge this …
  preprints 2025 置信度 0.74
• Metabolic Engineering of Terpenoid Biosynthesis in Medicinal Plants: From Genomic Insights to Biotechnological Applications
  preprints 2025 置信度 0.74
• Bistability in Gene Regulation: Simulating Positive Feedback and Toggle Circuits Using Python and Hill Functions
  ABSTRACT Cellular decision-making relies heavily on bistable gene regulatory networks, which allow systems to respond to internal or external stimuli by switching between several stable expression states. Processes like cell differentiation, epigenetic memory,…
  preprints Y K Yathu Krishna 2025 置信度 0.74
• Protein structure prediction and design for high-throughput computing
  Recent advances in structural biology and machines learning have resulted in a revolution in molecular biology. This revolution is driven by protein structure prediction and design tools such as Alphafold3, Chai-1, and Boltz-2 which are now able to accurately …
  preprints 2025 置信度 0.74
• A sulfatide-centered ultra-high resolution magnetic resonance MALDI imaging benchmark dataset for MS1-based lipid annotation tools
  preprints 2025 置信度 0.74
• Born to Condense: Polysomes Drive Co-Translational Condensation of Biomolecular Condensate Proteins
  preprints 2025 置信度 0.74