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با اعمال تمامی اصلاحات، رفع اشکالات کامپایلری و بهینهسازیهای پیشرفتهی خواستهشده توسط دادگاه عالی کامپایلر Lean 4 (استفاده از تاکتیکهای قدرتمند positivity و ring_nf جهت حذف کامل هرگونه هشدار یا خطای احتمالی)، مجموعه ۳گانه کامل و نهایی نظریه شماره ۳۱ از ۱…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
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با اعمال تمامی اصلاحات، رفع اشکالات کامپایلری و بهینهسازیهای پیشرفتهی خواستهشده توسط دادگاه عالی کامپایلر Lean 4 (استفاده از تاکتیکهای قدرتمند positivity و ring_nf جهت حذف کامل هرگونه هشدار یا خطای احتمالی)، مجموعه ۳گانه کامل و نهایی نظریه شماره ۳۱ از ۱…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
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با اعمال تمامی اصلاحات، رفع اشکالات کامپایلری و بهینهسازیهای پیشرفتهی خواستهشده توسط دادگاه عالی کامپایلر Lean 4 (استفاده از تاکتیکهای قدرتمند positivity و ring_nf جهت حذف کامل هرگونه هشدار یا خطای احتمالی)، مجموعه ۳گانه کامل و نهایی نظریه شماره ۳۱ از ۱…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
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A widespread phenomenon exists across complex systems: minor perturbations can either be absorbed by the system and fade away, or trigger irreversible cascading amplification under specific conditions, ultimately leading to fundamental state transitions of the…
datacite
Xu, Jianjun
2026
置信度 0.66
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A widespread phenomenon exists across complex systems: minor perturbations can either be absorbed by the system and fade away, or trigger irreversible cascading amplification under specific conditions, ultimately leading to fundamental state transitions of the…
datacite
Xu, Jianjun
2026
置信度 0.66
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This paper explores the application of genetic algorithms (GAs), drawing inspiration from synthetic biology's evolutionary principles, to the design of complex computational circuits. The core concept involves representing circuit designs as "genes" and utiliz…
datacite
Zhang, Jincheng
2026
置信度 0.66
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This paper explores the application of genetic algorithms (GAs), drawing inspiration from synthetic biology's evolutionary principles, to the design of complex computational circuits. The core concept involves representing circuit designs as "genes" and utiliz…
datacite
Zhang, Jincheng
2026
置信度 0.66
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فاز صدم - بخش دهم (C): لنگرِ دیکامپایلِ بیگبنگ و ساب-روتینِ مقداردهیِ اولیه در لایهی اَبَرسورس ($\text{Big Bang De-compilation Anchor \& Hyper-Source Initialization}$) ۱. اسکریپت پیشرفته پایتون ($\text{HIP Phase C Master Engine}$ برای لنگر دیکامپایل بیگبن…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
-
فاز صدم - بخش دهم (C): لنگرِ دیکامپایلِ بیگبنگ و ساب-روتینِ مقداردهیِ اولیه در لایهی اَبَرسورس ($\text{Big Bang De-compilation Anchor \& Hyper-Source Initialization}$) ۱. اسکریپت پیشرفته پایتون ($\text{HIP Phase C Master Engine}$ برای لنگر دیکامپایل بیگبن…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
-
فاز صدم - بخش دهم (C): لنگرِ دیکامپایلِ بیگبنگ و ساب-روتینِ مقداردهیِ اولیه در لایهی اَبَرسورس ($\text{Big Bang De-compilation Anchor \& Hyper-Source Initialization}$) ۱. اسکریپت پیشرفته پایتون ($\text{HIP Phase C Master Engine}$ برای لنگر دیکامپایل بیگبن…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
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Abstract Synthetic biology has emerged as a transformative interdisciplinary field that integrates biology, engineering, and computational sciences to design and construct novel biological systems. Its rapid global deployment in areas such as medicine, agricul…
datacite
KandePatil, Priyanka
2026
置信度 0.66
Keywords: Synthetic biology; Biosafety; Biosecurity; Microbial engineering; Biocontainment; Risk assessment
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Abstract Synthetic biology has emerged as a transformative interdisciplinary field that integrates biology, engineering, and computational sciences to design and construct novel biological systems. Its rapid global deployment in areas such as medicine, agricul…
datacite
KandePatil, Priyanka
2026
置信度 0.66
Keywords: Synthetic biology; Biosafety; Biosecurity; Microbial engineering; Biocontainment; Risk assessment
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Helicobacter pylori infects approximately 44% of the global human population (over 3.5 billion individuals) and is classified as a Group I definite carcinogen by the WHO/IARC. Current antibiotic eradication therapies face critically escalating primary resistan…
datacite
Ojeda, Felipe
2026
置信度 0.66
Helicobacter pyloriBacteriophage therapyExtremophile Capsid EngineeringDe novo protein designAcid-resistant phage
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Helicobacter pylori infects approximately 44% of the global human population (over 3.5 billion individuals) and is classified as a Group I definite carcinogen by the WHO/IARC. Current antibiotic eradication therapies face critically escalating primary resistan…
datacite
Ojeda, Felipe
2026
置信度 0.66
Helicobacter pyloriBacteriophage therapyExtremophile Capsid EngineeringDe novo protein designAcid-resistant phage
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Virtual screening is a mature but fragmented discipline: a typical campaign requires separate tools for receptor preparation, library curation, protonation, 3D generation, multi-engine docking, scoring, ADMET profiling and figure generation, each with its own …
datacite
Nikosin, Tomas
2026
置信度 0.66
Molecular Docking Simulationvirtual screeningdrug repurposingopen-source softwareADMET profiling
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Chemo informatics, which includes the creation, evaluation, and application of chemical information to support the creation of novel drugs, has developed into an important fieldinthedrug discovery process. Its importance has grown throughout biology, biochemis…
datacite
Fazila, Syed Rizwan Abbas
2025
置信度 0.66
Chemoinformaticssynthetic routesdrug discoverymachine learningvirtual screening.
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Chemo informatics, which includes the creation, evaluation, and application of chemical information to support the creation of novel drugs, has developed into an important fieldinthedrug discovery process. Its importance has grown throughout biology, biochemis…
datacite
Fazila, Syed Rizwan Abbas
2025
置信度 0.66
Chemoinformaticssynthetic routesdrug discoverymachine learningvirtual screening.
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It is impossible to imagine modern medicine without antibiotics. Unfortunately, rapid global rise of antimicrobial resistance (AMR) threatens to push humanity back to the pre-antibiotic era - a bleak reality when a simple, previously easily treatable infection…
datacite
Kennedy, Agata
2026
置信度 0.66
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Abstract This upgraded edition (v1.7) of the white paper presents the biogenic replicator, a desktop and implantable molecular compiler that converts digital sequence files directly into therapeutic biologics without fermentation or cold chain. A “Plain‑Langua…
datacite
Robert Ledgister
2026
置信度 0.66
Bioinformatic methods developmentProteomics and metabolomicsAnalytical biochemistryEnzymesProteomics and intermolecular interactions (excl. medical proteomics)
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Abstract This upgraded edition (v1.7) of the white paper presents the biogenic replicator, a desktop and implantable molecular compiler that converts digital sequence files directly into therapeutic biologics without fermentation or cold chain. A “Plain‑Langua…
datacite
Robert Ledgister
2026
置信度 0.66
Bioinformatic methods developmentProteomics and metabolomicsAnalytical biochemistryEnzymesProteomics and intermolecular interactions (excl. medical proteomics)
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The Revised Real-World Spec Sheet now both missile work Feature Fictional Version Real-World Engineering Solution Power Source 12 V / 10 Ah Battery Engine-Driven High-Output Alternator Stealth Ionized Plasma Shroud DRFM Electronic Jamming + Radar Absorbent Ski…
datacite
lee, francis
2026
置信度 0.66
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The Revised Real-World Spec Sheet now both missile work Feature Fictional Version Real-World Engineering Solution Power Source 12 V / 10 Ah Battery Engine-Driven High-Output Alternator Stealth Ionized Plasma Shroud DRFM Electronic Jamming + Radar Absorbent Ski…
datacite
lee, francis
2026
置信度 0.66
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Abstract We present a robust and versatile in vitro transcription (IVT) assay based on an optimized Broccoli RNA aptamer sequence. When paired with the fluorophore DFHBI-1T, this system enables real-time monitoring of multi-round transcription over several hou…
europepmc
Tina Lanzmaier, Elena Reiterer, Melanie Merl, Andonita Ajdari 等
2026
置信度 0.80
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We propose the Informational Field Consciousness Theory (IFCT), an integrative framework combining information physics, quantum biology, and neuroscience to address the Hard Problem of Consciousness. Central to our thesis is the hypothesis that DNA functions a…
preprints
Jimmy Y. Mahardhika
2025
置信度 0.74
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Synthetic biology is undergoing a pivotal shift from single-species engineering to rational design of synthetic microbial consortia, enabling more complex, efficient, and resilient functionalities. This transition responds to the growing demand for microbial a…
preprints
2025
置信度 0.74
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preprints
2026
置信度 0.74
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Metabolic engineering of mesenchymal stem/stromal cells (MSCs) represents a compelling frontier for advanced cellular therapies, enabling the precise tuning of their biological outputs. This feature paper examines the critical role of engineered culture microe…
preprints
Natalia Trufanova, Oleh Trufanov, Oleksandr Petrenko
2025
置信度 0.74
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While synthetic biology has traditionally focused on creating or redesigning biological systems often through genetic engineering, emerging technologies, for example, implantable pacemakers with integrated piezo-electric and tribo-electric materials are beginn…
preprints
Kuntal Kumar Das, Ashutosh Kumar Dubey, Bikramjit Basu, Yogendra Narain Srivastava
2025
置信度 0.74
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Indole-3-acetic acid (IAA) is the main natural auxin and a key regulator of plant growth. However, most commercial auxins are synthetically produced from non-renewable resources. Here, we present a minimal synthetic biology platform for microbial IAA productio…
preprints
Ana Lilia Hernández-Orihuela, Lucía Carolina Alzati-Ramírez, Agustino Martínez-Antonio
2026
置信度 0.74
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preprints
2026
置信度 0.74
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Abstract Rhodobacter sphaeroides is a purple non-sulphur alphaproteobacterium with a highly versatile metabolism. This microorganism holds promise as a chassis for sustainable biomanufacturing of numerous chemicals. Yet, its potential is constrained by a lack …
preprints
Matic Kostanjšek, Antoine Raynal, George Dimopoulos, Gerrich Behrendt 等
2025
置信度 0.74
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Abstract Periplasmic display in yeast is a promising but underdeveloped method for screening and studying genetically encoded biomolecules. We present PIONEER, a modular platform that localizes peptides, proteins, and nanobodies to the membrane-proximal peripl…
preprints
Jacob B. Rowe, Kyutae Lee, Daniel G. Isom
2025
置信度 0.74
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preprints
2025
置信度 0.74
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Plants have long adapted to the earth’s changing environmental patterns. Yet, 1 with the current rise of abiotic stresses, such as salinity, temperatures, drought, and nutrient 2 depletion occurring at unpredictable rates threaten global agriculture. If this p…
preprints
Vishnu Sri Suma Pagolu
2025
置信度 0.74
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Modern agriculture is at a crossroads, facing the dual crises of growing fungicide resistance and the adverse environmental impact of conventional agrochemicals. This scenario demands a paradigm shift that goes beyond the simple substitution of chemical produc…
preprints
Víctor Coca-Ruiz
2025
置信度 0.74
FungicideRNA interferenceBiologyGenomeComputational biology
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The gut microbiota plays a pivotal role in modulating immune responses and influencing brain function through the microbiota-immune-brain axis. Disruptions in this axis have been implicated in various neuroinflammatory disorders, including multiple sclerosis, …
preprints
Mohammad Odah
2025
置信度 0.74
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Abstract Excess environmental copper from industrial and agricultural sources poses significant risks to ecosystems and human health. We engineered a whole-cell Escherichia coli biosensor to rapidly detect bioavailable Cu(II) ions using a copper-inducible gene…
preprints
Yaman Yazici
2025
置信度 0.74
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The global drive toward a circular bioeconomy is accelerating the demand for sustainable, high-performance materials. Filamentous fungi offer a compelling solution, functioning as living foundries that transform low-value biomass into advanced materials via se…
preprints
Víctor Coca-Ruiz
2025
置信度 0.74
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Abstract Heavymetal contamination persists in water, soil, and sediments owing to its toxicity, bioaccumulation potential, and continuous inputs from mining, metallurgy, and ewaste processing. Synthetic biology offers a route to engineer microbes and microalga…
preprints
Kartik Tiwary
2025
置信度 0.74
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Abstract Background Chimeric antigen receptor (CAR)-based immunotherapies face significant translational challenges in solid tumor applications, particularly regarding manufacturing scalability, tumor targeting specificity, and antigen heterogeneity. This syst…
preprints
Sanjay S Gottipamula
2025
置信度 0.74
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Photosynthetic efficiency in crops is a major limiting factor in agricultural productivity and climate resilience. Synthetic biology provides novel approaches to reprogram photosynthesis by engineering carbon fixation pathways, optimizing RuBisCO efficiency, a…
preprints
Mohammad Odah
2025
置信度 0.74
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preprints
2024
置信度 0.74
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Abstract Quorum sensing systems have a broad range of applications within the field of synthetic biology. However, a bottleneck is the optimization and tuning of these systems due to the lack of standardization and complete characterization. In this research, …
preprints
De Baets Jasmine, De Paepe Brecht, De Mey Marjan
2025
置信度 0.74
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preprints
2025
置信度 0.74
-
preprints
2025
置信度 0.74
-
preprints
2025
置信度 0.74
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The increasing prevalence of multi-drug-resistant (MDR) bacterial pathogens presents a critical global health threat, highlighting the urgent need for innovative approaches to understanding bacterial patho-genesis and developing effective therapies. This revie…
preprints
Rajdeep Banerjee
2024
置信度 0.74
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Abstract Efficient gene integration using RNA-guided endonucleases has not yet been achieved in the mitochondrial genome. Import of nucleic acids into mitochondria, a controversial feature, is essential for implementation of Cas9-mediated genome engineering of…
preprints
Charlotte C. Koster, Kavish Kohabir, Maxime den Ridder, Marijke A.H. Luttik 等
2025
置信度 0.74
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This work explores the integration of machine learning (ML) and mechanistic models (MM). While ML has demonstrated remarkable success in data-driven modeling across engineering, biology, and other scientific fields, MM remain essential for their interpretabili…
preprints
2025
置信度 0.74
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Global food insecurity and environmental degradation creates the need to develop more sustainable agricultural solutions. Plant synthetic biology emerges as a promising yet risky avenue to develop such solutions. While synthetic biology promises enhanced crop …
preprints
Abel Lucido, Oriol Basallo, Alberto Marin-Sanguino, Abderrahmane Eleiwa 等
2024
置信度 0.74
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Abstract Naturally occurring DNA inversion systems play an important role in the generation of genetic variation and adaptation in prokaryotes. Shufflon invertase (SI) Rci from plasmid R64, recognizing asymmetric sfx sites, has been adopted as a tool for synth…
preprints
Jan Katalinić, Morgan Richards, Alex Auyang, James H. Millett 等
2024
置信度 0.74
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Abstract Women and racial minorities are underrepresented in the synthetic biology community. Developing a scholarly identity by engaging in a scientific community through writing and communication is an important component for STEM retention, particularly for…
preprints
Louis A. Roberts, Natalie G. Farny
2024
置信度 0.74
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Abstract Carboxysomes are polyhedral protein organelles that microorganisms use to facilitate carbon dioxide assimilation. They are composed of a modular protein shell which envelops an enzymatic core mainly comprised of physically coupled Rubisco and carbonic…
preprints
Daniel S. Trettel, Y Hoang, Anthony G. Vecchiarelli, Cesar R. Gonzalez-Esquer
2024
置信度 0.74
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Abstract Certain applications of synthetic biology rely on the construction of large and complex DNA sequences. Current DNA synthesis technologies are limited in their capacity to generate ultra-long oligonucleotide for complex gene construction with extensive…
preprints
Mancang Zhang, Yang Hu, Hao Huang, Yongyong Shi
2025
置信度 0.74
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Abstract Synthetic biology, or “SynBio”, cleverly mimics nature to help achieve sustainability goals and meet civilisation's needs. It enables the transition to an economic paradigm based on biological processes. Although synthetic biology is an embryonic tech…
preprints
Suhad A. A. Al-Salihi, Kathryn L. Ford, Murnita M. Mahyudin, Hamidun Bunawan
2024
置信度 0.74
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preprints
2024
置信度 0.74
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Synthetic biology uses engineering principles to redesign organisms and construct biological systems with specific functions, which is an important way to develop drugs, vaccines, biofuels, etc. In the process of transforming synthetic organisms, researchers n…
preprints
Sidi Li, Cui Ma, Fan Yang, Shu Chen 等
2024
置信度 0.74
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preprints
2025
置信度 0.74
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ABSTRACT Controllable gene circuits that respond to defined inputs are essential tools in synthetic biology. By leveraging regulatory mechanisms at either transcriptional or translational levels, synthetic responsive systems have been engineered to recognize d…
preprints
Brian Ng, Yuying Ding, Matthew Cornall, Ravinash Krishna Kumar 等
2024
置信度 0.74
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Abstract The ability to control gene expression is pivotal in genetic engineering and synthetic biology. However, in most non-model and pest insect species, empirical evidence for predictable modulation of gene expression levels is lacking. This knowledge gap …
preprints
Philip T. Leftwich, Jessica C. Purcell, Michelle A.E. Anderson, Rennos Fragkoudis 等
2023
置信度 0.74
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Abstract The human gut is a highly dynamic physical environment where perturbations—including factors such as acidification, oxygenation, and particle concentration (osmolality)—can influence microbiota composition and contribute to disease states. Understandi…
preprints
Giselle McCallum, Juan C. Burckhardt, Jerry He, Alice Hong 等
2025
置信度 0.74
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preprints
2024
置信度 0.74
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Organisms from the genus Streptomyces feature actinobacteria with complex developmental cycle and great ability to produce a variety of natural products, which is possible due to complicated crosstalk between primary and secondary metabolism. These soil bacter…
preprints
Sergii Krysenko
2024
置信度 0.74
-
europepmc
2024
置信度 0.80
-
Synechococcus elongatus PCC 11801 is a fast-growing cyanobacterium, exhibiting high tolerance to environmental stresses. We have earlier characterized its genome and analysed its transcriptome and proteome. However, to deploy it as a potential cell factory, it…
preprints
Pramod Wangikar, Swati Madhu, Annesha Sengupta, ADITYA SARNAIK
2024
置信度 0.74
-
preprints
2024
置信度 0.74
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Based on the fact that the solar system will eventually be destroyed and that humans cannot travel to the nearest habitable exoplanet within a lifetime, this article suggests sending synthetic biology- and AI- created astronauts with some plant characteristics…
preprints
Tianxi Sun
2024
置信度 0.74
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ABSTRACT Engineered DNA will slow the growth of a host cell if it redirects limiting resources or otherwise interferes with homeostasis. Populations of engineered cells can rapidly become dominated by “escape mutants” that evolve to alleviate this burden by in…
preprints
Noor Radde, Genevieve A. Mortensen, Diya Bhat, Shireen Shah 等
2024
置信度 0.74
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Quorum sensing (QS) is a sophisticated bacterial cell-to-cell communication mechanism that allows bacteria to sense population density through the secretion and detection of diffusible small molecular signals. This process leads to the coordinated expression o…
preprints
2024
置信度 0.74
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Quorum Sensing (QS) and Machine Learning (ML) hybrid systems represent a groundbreaking innovation in synthetic biology, offering unprecedented control and adaptability in microbial gene regulation and metabolic processes. QS, a microbial communication mechani…
europepmc
Dang Anh Tuan, Pham Vu Nhat Uyen, Jan Masak
2024
置信度 0.80
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preprints
2025
置信度 0.74
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The article explores the concept of 'synthetic man' (SM) in the context of 'synthetic biology' (SB), analysing the potential, challenges, and ethical implications of these achievements. Through dialogue with ChatGPT 4, an in…
preprints
Alexandru Tugui, Denisa-Oana Zelinschi
2024
置信度 0.74
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preprints
2024
置信度 0.74
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Abstract Chloroplast synthetic biology holds promise for developing improved crops through improving the function of plastids. However, chloroplast engineering efforts face limitations due to the scarcity of genetic tools and the low throughput of plant-based …
preprints
René Inckemann, Tanguy Chotel, Cedric K. Brinkmann, Michael Burgis 等
2024
置信度 0.74
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preprints
2024
置信度 0.74
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Abstract Synthetic and chimeric receptors capable of recognizing and responding to user-defined antigens have enabled “smart” therapeutics based on engineered cells. These cell engineering tools depend on antigen sensors which are most often derived from antib…
preprints
Zara Y. Weinberg, Sarah S. Soliman, Matthew S. Kim, Devan H. Shah 等
2024
置信度 0.74
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preprints
2023
置信度 0.74
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Abstract Inducible gene expression systems can be used to control the expression of a gene of interest by means of a small-molecule. One of the most common designs involves engineering a small-molecule responsive transcription factor (TF) and its cognate promo…
preprints
Giuliano De Carluccio, Virginia Fusco, Diego di Bernardo
2023
置信度 0.74
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ABSTRACT The ability to induce heritable genomic changes in response to environmental cues is valuable for environmental biosensing, for experimentally probing microbial ecology and evolution, and for synthetic biology applications. Site-specific recombinases …
preprints
Elisa Garabello, Hyun Yoon, Matthew C. Reid, Andrea Giometto
2024
置信度 0.74
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preprints
2023
置信度 0.74
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While rapidly becoming a main thread in the development of new therapies, the rise of synthetic biology is also tied to concerns about the potential impact on ecosystems. That is particularly relevant in the of deployment in natural habitats, including the hum…
preprints
Blai Vidiella, Ricard Sole
2022
置信度 0.74
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Abstract Escherichia coli Nissle 1917 (EcN) is a probiotic microbe that has the potential to be developed as a promising chassis for synthetic biology applications. However, the molecular tools and techniques for utilizing EcN have not been fully explored. To …
preprints
Fang Ba, Yufei Zhang, Xiangyang Ji, Wan-Qiu Liu 等
2023
置信度 0.74
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preprints
2023
置信度 0.74
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preprints
2023
置信度 0.74
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Abstract Background The oleaginous yeast Yarrowia lipolytica is increasingly used as a chassis strain for generating bioproducts. Several hybrid promoters with different strengths have been developed by combining multiple copies of an upstream activating seque…
preprints
Lea Vidal, Esteban Lebrun, Young-Kyoung Park, Guillaume Mottet 等
2022
置信度 0.74
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Abstract The rise in frequency of antibiotic resistance has made bacterial infections, specifically Pseudomonas aeruginosa , a cause for greater concern. Phage therapy is a promising solution that uses naturally isolated phages to treat bacterial infections. E…
preprints
Thomas IPOUTCHA, Ratanachat RACHARAKS, Stefanie HUTTELMAIER, Cole WILSON 等
2023
置信度 0.74
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ABSTRACT Engineered autonomous bioluminescence (EAB) offers many potential applications in Plant Synthetic Biology, notably as in vivo reporter system. Current EAB reporter configurations are limited for quantitative applications due to low dynamic range. We r…
preprints
Camilo Calvache, Marta Vazquez-Vilar, Elena Moreno-Giménez, Diego Orzaez
2023
置信度 0.74
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preprints
2023
置信度 0.74
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Abstract Yeasts have established themselves as prominent microbial cell factories, and the availability of synthetic biology tools has led to breakthroughs in the rapid development of industrial chassis strains. The selection of a suitable microbial host is cr…
preprints
Young-Kyoung Park, Tristan Rossignol
2023
置信度 0.74
-
preprints
2023
置信度 0.74
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Abstract Predicting the dynamics of mutation spread in engineered cell populations is a sought- after goal in synthetic biology. Until now, models that capture these processes have been lacking, either by failing to account for the diversity of mutation types,…
preprints
Duncan Ingram, Guy-Bart Stan
2022
置信度 0.74
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preprints
2022
置信度 0.74
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preprints
2023
置信度 0.74
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preprints
2023
置信度 0.74
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preprints
2021
置信度 0.74
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preprints
2022
置信度 0.74
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preprints
2022
置信度 0.74
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preprints
2022
置信度 0.74
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preprints
2021
置信度 0.74
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preprints
2022
置信度 0.74