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• Defining and redefining its role in biology: Synthetic biology as an emerging field at the interface of engineering and biology
  preprints 2016 置信度 0.74
• Advances on Anti-Cancer Combination Therapies Targeting DNA Repair Pathway, Epigenetics, Microbiomes and the Immune System
  preprints 2026 置信度 0.74
• Plant DNA Designer: A Computational Framework for Multi-Objective Codon Optimisation and Synthetic Gene Design in Crop Biotechnology
  preprints 2026 置信度 0.74
• Sugar-Driven Information Loss in Minimal Synthetic Cells as a Model for Metabolic Aging
  preprints 2026 置信度 0.74
• A Robust and Scalable Workflow for the Production of Circular Single-Stranded DNA for Genome Engineering Applications
  preprints 2026 置信度 0.74
• Programming Metabolic Dependency in Synthetic Cells Under Resource Scarcity
  europepmc 2026 置信度 0.80
• Automated Synthetic Cell-based Screening for Designed Proteins with Emergent Functions
  Abstract Designing minimal biological systems with emergent functions such as spatiotemporal self-organization is a central goal of bottom-up synthetic biology. While computational optimization and design show promises to accelerate functional protein engineer…
  preprints Kareem Al Nahas, Béla P. Frohn, Aleksandra Šakanović, Frank Siedler 等 2026 置信度 0.74
• Asymmetric Structural Transfer Between Natural Language and Biological Foundation Models
  preprints 2026 置信度 0.74
• netPCF: Geometry-aware pair correlation functions for spatial biology
  preprints 2026 置信度 0.74
• Physiological, Behavioral, and Genetic Factors that Shape Interactions in a Plant-Growth-Promoting Maize Rhizosphere Synthetic Community
  preprints 2026 置信度 0.74
• A Transformer-based Multi-omics Model for Translation Efficiency in <i>S. cerevisiae</i>
  preprints 2026 置信度 0.74
• Metal Coordination Dynamics Governs Selective Epoxidation in Hyoscyamine 6β-Hydroxylase: Integrated Experimental and Computational Insights
  preprints 2026 置信度 0.74
• Ecological constraints to mirror life
  preprints 2026 置信度 0.74
• Orthogonal Acoustic Control of Gene Expression Using a Synthetic T7RNAP Rapa-Inducible Dimerization System
  preprints 2026 置信度 0.74
• Adeno-associated Virus (AAV) Synthetic Inverted Terminal Repeat Enhances Tissue Specific Transduction and Altered Vector Induced Stress Response
  preprints 2026 置信度 0.74
• Genetic and Biochemical Characterization Reveals PduU as a Modular Tool for Tuning Pdu Microcompartment Permeability
  preprints 2026 置信度 0.74
• Evolutionary Origins and Synthetic Reconstruction of Gingerols
  preprints 2026 置信度 0.74
• DNA condensate-based organelles for spatially regulated gene expression and protein targeting in synthetic cells
  Abstract Spatial organization of gene expression is a key feature of cells but remains a major challenge in bottom-up synthetic biology. While phase-separated DNA condensates have been used to spatially confine transcription, achieving efficient recruitment of…
  preprints Nastasja Kaletta, Martin Matl, Petra Schwille 2026 置信度 0.74
• Symbolic regression enables coarse-grained model discovery of intracellular signalling dynamics
  preprints 2026 置信度 0.74
• Quantitative Engineering and Investigation of Synthetic Sponge RNAs in <i>E. coli</i>
  Abstract Sponge RNAs (spRNAs) play an important regulatory role in bacterial small RNA (sRNA) networks, but their engineering and quantitative systems-level properties are unexplored. Here, we design, build, and quantitatively characterise synthetic spRNA-base…
  preprints Scott B. Stacey, Kirill Sechkar, Marco Corrao, Harrison Steel 等 2026 置信度 0.74
• MozClo: An Expanded MoClo Toolset for Large Multigene Assembly and Plant Transformations
  The Modular Cloning (MoClo) and PhytoBrick standards have revolutionized plant synthetic biology by establishing a standardized, hierarchical assembly grammar. However, as the engineering of complex metabolic pathways, multi-trait stacks, and synthetic gene ci…
  preprints Grant Straub, Devyn Aldrich, Cory Tobin 2026 置信度 0.74
• An Open-Source Magnetofluorescence Imaging Platform for Plate-Scale Screening of Magnetic Field Effects in Live Bacteria
  preprints 2026 置信度 0.74
• Toward a Testable Blueprint for Synthetic Consciousness
  preprints 2026 置信度 0.74
• Landauer in the age of synthetic biology: energy consumption and information processing in biochemical networks
  A central goal of synthetic biology is to design sophisticated synthetic cellular circuits that can perform complex computations and information processing tasks in response to specific inputs. The tremendous advances in our ability to understand and manipulat…
  preprints Pankaj Mehta, Alex H. Lang, David J. Schwab 2015 置信度 0.74
• Adversarial Validation Reveals Diagnostic Workflow Leakage in PCOS Machine Learning Models
  Background Machine-learning models for polycystic ovary syndrome (PCOS) and other conditions frequently report near-perfect diagnostic performance, but retrospective datasets assembled from routine clinical practice can encode diagnostic-group membership in ho…
  preprints 2026 置信度 0.74
• Small RNA-guided transgene repression systems enable toxic gene cloning in bacteria
  preprints 2026 置信度 0.74
• A two-step selection method for in vitro evolution of translational proteins
  preprints 2026 置信度 0.74
• Ori-Finder-Arch: An Updated Web Server for the Annotation and Visualization of Archaeal Replication Origins
  preprints 2026 置信度 0.74
• Chemically tunable permeability of engineered alpha-Hemolysin in synthetic cells
  Abstract Controlling molecular transport across membranes is a defining feature of living cells, yet replicating this functionality in synthetic systems remains a major challenge. Self-inserting protein nanopores, such as α-hemolysin (αHL), offer a promising r…
  preprints Elisabeth Bobkova, Anastasia Götz, Frank Abendroth, Olalla Vázquez 等 2026 置信度 0.74
• Why architecture matters: Controlling gene expression through design
  Inducible gene expression systems are widely used in synthetic biology and gene therapy, yet their performance depends not only on regulator chemistry but also on circuit architecture. Here, we examine how promoter organization shapes TetR-based gene regulatio…
  preprints 2026 置信度 0.74
• Multi-stage physics-informed neural networks for JAK–STAT5 signaling and ultradian insulin–glucose dynamics: latent-species identifiability and suppression of parameter-induced divergence
  preprints 2026 置信度 0.74
• Biosynthetic Diversity of Marine <em>Streptomyces</em>-Derived Natural Products: From Genome Mining to Drug Discovery
  preprints 2026 置信度 0.74
• Programmable CRISPRtune dissects the transcriptional repressive activity of MeCP2
  preprints 2026 置信度 0.74
• Receptors: A Historical Journey, Current Landscape and Future Trajectories in Molecular Biology and Medicine
  preprints 2026 置信度 0.74
• Synthetic cell-cell adhesion provides benefits of proximity without diffusion-related costs
  preprints 2026 置信度 0.74
• Intracellularly Coupled Oscillators for Synthetic Biology
  Abstract Synthetic biology aims to engineer or re-engineer living systems. To achieve increasingly complex functionalities, it is beneficial to use higher-level building blocks. In this study, we focus on oscillators as such building blocks, propose novel osci…
  europepmc Gábor Holló, Jung Hun Park, Rose Evard, Yolanda Schaerli 2025 置信度 0.80
• Engineered bacterial therapeutics from synthetic biology to clinical translation: A multi-database scientometric analysis, 2000-2026.
  europepmc 2026 置信度 0.80
• Methylotrophic yeast engineering for secreted protein production via precision fermentation: food ingredient proteins and synthetic biology strategies.
  europepmc 2026 置信度 0.80
• AI-Assisted Spatial Metabolic Engineering in Plants: Integrating Flux Design, Spatial Omics, and Synthetic Biology.
  europepmc 2026 置信度 0.80
• Reconstructing food colorants via synthetic biology: From microbial cell factories to sustainable biomanufacturing supply chains.
  europepmc Zeyu Li, Jiali Zhang, Junsong Xiao, Yingying Zhu 等 2026 置信度 0.80
• Bacteriophage P22 virus-like particles as nanoscale protein scaffolds for plant synthetic biology
  Abstract Advancing the utility of plant synthetic biology requires the continued development of protein engineering tools. Self-assembling protein compartments, such as virus-like particles (VLPs), provide versatile scaffolds for synthetic biology. However, fe…
  europepmc Maxim D. Harding, Mark A. Jackson, Edward K. Gilding, David J. Craik 等 2026 置信度 0.80
• Advances in combinatorial CRISPRi screening and applications: Decoding higher-order interactions for next-generation microbial cell factories in synthetic biology.
  Biological systems possess high robustness and intricate genetic redundancy, rendering traditional single-gene perturbations largely inadequate for comprehensively elucidating the true regulatory mechanisms underlying complex phenotypes. To address this, combi…
  pubmed Zhu X, Zhang W, Sun T, Chen L 2026 置信度 0.82
• Recombinant live biotherapeutics and synthetic biology: Recent advancement and perspective.
  europepmc Karan Murjani, Dharmisha Solanki, Vijai Singh 2026 置信度 0.80
• Model-guided design of regulatable promoters for synthetic biology.
  europepmc 2026 置信度 0.80
• Plant Synthetic Biology Takes Off: Bryophytes Onboard with New Tools, Systems, and Opportunities.
  Plant synthetic biology is a highly innovative field that aims to better understand, redesign, and reprogram plants. Progress in recent years has been driven by technical developments such as modular cloning, gene circuits, genome editing, and synthetic genomi…
  europepmc Eftychios Frangedakis 2026 置信度 0.80
• [Applications of protein structure determination in synthetic biology].
  europepmc 2025 置信度 0.80
• Artificial intelligence and synthetic biology in traditional Chinese medicine: revolutionizing public health applications.
  europepmc 2026 置信度 0.80
• Next-Generation Bionic Sensors for Small Molecule Detection: Integrating Synthetic Biology, Nanomaterials, and Artificial Intelligence.
  Bionic sensors are emerging as powerful analytical platforms driving the development of next-generation detection technologies, particularly for small molecule sensing in complex environmental and biological systems. However, accurate and selective detection o…
  pubmed Barazandegan Y, Kc D, Iha R, Tu N 等 2026 置信度 0.82
• Plant synthetic biology: from knowledge to biomolecules.
  europepmc 2025 置信度 0.80
• Synthetic Biology Strategies for Harnessing Bacterial Glucose Oxidation Pathways.
  europepmc Runjie Wang, Peilei Feng, Qingzhuo Wang, Zhenyu Wang 等 2026 置信度 0.80
• Biodesulfurization: Back on-stage through synthetic biology and metabolic engineering approaches.
  europepmc 2026 置信度 0.80
• Using Synthetic Biology to Improve Global Vaccine Distribution
  The COVID-19 pandemic highlighted many inequities in global vaccine accessibility and distribution, negatively impacting disease control. Advancements in synthetic biology have produced recombinant protein vaccines and RNA-based vaccines as new methods to enha…
  europepmc Jocelyn Hinchcliffe, Bethany Atwood, Madelaine Freitas, Samantha Lopez 等 2025 置信度 0.80
• The next frontier: Exploring plant hypoxia sensing and response mechanisms through synthetic biology.
  europepmc 2026 置信度 0.80
• Geminivirus vectors: From gene silencing to synthetic biology.
  europepmc 2026 置信度 0.80
• Engineering <i>S. cerevisiae</i> extracellular vesicles using synthetic biology
  ABSTRACT Extracellular vesicles (EVs) hold great promise as therapeutic delivery vehicles, leveraging their natural role as mediators of intercellular communication in all organisms studied. However, many barriers must be overcome to realize their full potenti…
  europepmc Jeff Bouffard, Joseph Trani, Alexander Christophe Pawelczak, Marie Laufens 等 2026 置信度 0.80
• Generative AI for synthetic biology: Designing biological parts, circuits, and genomes.
  Synthetic biology aims to achieve predictable, programmable control over living systems by designing and engineering biological components and functions. Over the past 25 years, the field has advanced from foundational molecular tools to increasingly complex s…
  europepmc 2026 置信度 0.80
• Synthetic biology empowers development of traditional Chinese medicine.
  europepmc Chun Li 2025-11-21T02:55:29Z 置信度 0.80
• The Global Decarbonisation Potential of Synthetic Biology.
  ABSTRACT Synthetic biology‐based technologies can impact many sectors and are often targeted at improved environmental outcomes. Here, we discuss synthetic biology applications that can lead to long‐term decarbonisation and quantify the potential using a top‐d…
  europepmc Anthony Wiskich, Robert Speight 2025 置信度 0.80
• Synthetic biology for sustainable food colourant production: Innovations and opportunities.
  europepmc 2026 置信度 0.80
• SynVectorDB: embedding-based retrieval system for synthetic biology parts.
  Abstract Synthetic biology part discovery faces significant challenges due to inconsistent data organization and limited semantic search capabilities across existing repositories. We developed SynVectorDB, an embedding-based retrieval system that addresses the…
  europepmc Hao Li, Jiani Hu, Jie Song, Wei Zhou 2025-12-15T12:33:51Z 置信度 0.80
• Editorial: Synthetic biology and metabolomics: novel insight in oncology research.
  europepmc 2025 置信度 0.80
• Key Technologies of Synthetic Biology in Industrial Microbiology.
  europepmc 2025 置信度 0.80
• Astaxanthin biomanufacturing under hierarchical constraints: Integrating synthetic biology and artificial intelligence for scalable production.
  europepmc 2026 置信度 0.80
• Leveraging a synthetic biology approach to enhance BCG-mediated expansion of Vγ9Vδ2 T cells.
  europepmc 2026 置信度 0.80
• Engineering cis- and trans-acting RNA regulators for next-generation prokaryotic synthetic biology.
  europepmc 2026 置信度 0.80
• Chemically synthesized high-fidelity oligos ≤ 600 nt as building blocks to accelerate complex gene construction in synthetic biology.
  europepmc 2026 置信度 0.80
• Synthetic biology for space exploration.
  europepmc 2025 置信度 0.80
• Dynamic response phenotypes and model discrimination in systems and synthetic biology
  Many biological systems encode function not primarily in steady states, but in the structure of transient responses elicited by time-varying stimuli. Overshoots, biphasic dynamics, adaptation kinetics, foldchange detection, entrainment, and cumulative exposure…
  europepmc Eduardo Sontag, Eduardo D Sontag 2026 置信度 0.80
• Synthetic biology approaches to enhance cancer immune responses.
  Synthetic biology is being widely applied in tumor therapy, ranging from attenuating microbial toxicity to constructing synthetic gene circuits and developing CAR-T cells, all of which are reshaping the landscape of cancer immunotherapy. In this review, we sum…
  europepmc 2025 置信度 0.80
• Leveraging pre-trained AI models for robust promoter sequence design in synthetic biology.
  europepmc 2026 置信度 0.80
• From signals to solutions: stress-induced leaf senescence and synthetic biology and AI approaches for crop resilience.
  europepmc 2026 置信度 0.80
• Engineering Naematelia aurantialba as a Robust Synthetic Biology Chassis: Stable Episomal Vector Construction and Metabolic Optimization for Enhanced Polysaccharide Synthesis.
  Naematelia aurantialba is a promising basidiomycete chassis for bioproduction, yet its development is hindered by a lack of efficient genetic tools. This study established a robust genetic platform for N. aurantialba NX-20. First, protoplast regeneration was o…
  pubmed Ma Y, Wang Y, Zhang M, Sun L 等 2026 置信度 0.82
• A Comprehensive Review on Metabolomics-Guided Metabolite Production in Plant Tissue Culture: Integrating Omics and Synthetic Biology for Enhanced Yields.
  The growing bioeconomy demands sustainable platforms for the production of high-value pharmaceuticals, nutraceuticals, and industrial compounds. Plant tissue culture (PTC) is an attractive alternative as it provides a means of controlled production of secondar…
  pubmed Manas Manam, K. Sankalp Srivatsa, Asmita Mishra, Marttin Paulraj Gundupalli 等 2026 置信度 0.82
• Synthetic biology-driven innovations in triple-negative breast cancer: Integrating engineering design with targeted therapeutics.
  Triple-negative breast cancer (TNBC) is a highly aggressive malignancy with limited therapeutic options and poor clinical outcomes due to the absence of hormone-responsive receptors. The advent of synthetic biology, which integrates molecular biology with engi…
  europepmc 2026 置信度 0.80
• Systems biology can provide guidance to synthetic biology in the pursuit of new drug targets.
  Many diseases are caused by an elevated or decreased level of some metabolite but it is not always a priory clear which process or processes associated with the metabolite could or should be altered pharmaceutically to effect a return to normalcy. With a case …
  europepmc Eberhard O. Voit 2026 置信度 0.80
• [Application of synthetic biology in contamination remediation of the petrochemical industry].
  europepmc 2025 置信度 0.80
• [Plant synthetic biology technologies and natural product biosynthesis].
  europepmc 2025 置信度 0.80
• Ultra-rapid and high-titer biomanufacturing of trehalose 6-phosphate by an in vitro synthetic biology platform.
  europepmc 2026 置信度 0.80
• Genetic code expansion: Bridging synthetic biology precision and cellular complexity to decipher molecular mechanisms of diseases.
  europepmc 2026 置信度 0.80
• A Framework for a Standard-Enabled FAIR Data Management Workflow for Synthetic Biology.
  europepmc Carolus Vitalis, Gonzalo Vidal, Sai P. Samineni, Pedro Fontanarrosa 等 2026 置信度 0.80
• Editorial: Synthetic biology approaches for biocatalytic production of value-added chemicals.
  europepmc 2025 置信度 0.80
• Building an expanded bio-based economy through synthetic biology.
  europepmc 2026 置信度 0.80
• Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications.
  europepmc 2026 置信度 0.80
• Optogenetic tools for optimizing key signalling nodes in synthetic biology.
  europepmc 2026 置信度 0.80
• Engineering the holobiont: Synthetic biology strategies for reversing bioenergetic collapse in radiation enteritis.
  Radiation enteritis (RE) constitutes a catastrophic collapse of the intestinal holobiont, fundamentally constraining the curative potential of abdominopelvic radiotherapy. Current clinical management, limited by a reductionist focus on host DNA damage, often o…
  europepmc 2026 置信度 0.80
• Combining model-based and data-driven models: An application to synthetic biology resource competition.
  europepmc 2026 置信度 0.80
• On the Choice of the Right Plasmid Vector(s) in the Times of Synthetic Biology.
  europepmc 2025 置信度 0.80
• Rhodo-Box: A Synthetic Biology Toolbox to Facilitate Metabolic Engineering of &lt;i&gt;Rhodobacter sphaeroides&lt;/i&gt;.
  europepmc 2026 置信度 0.80
• A synthetic biology toolkit for the plasmid-dependent and thermophilic methylotroph Bacillus methanolicus.
  europepmc 2026 置信度 0.80
• Engineering microbial therapeutics for metabolic disorders: synthetic biology strategies and future direction.
  europepmc 2026 置信度 0.80
• Engineering synthetic biology sensors with artificial intelligence: From programmable circuits to next-generation biosensing.
  Artificial intelligence (AI) is advancing synthetic biology biosensors (SBBs), driving a fundamental shift from rational design to AI-driven prediction. This review establishes a systematic framework linking AI algorithms to the Design-Build-Test-Learn (DBTL) …
  europepmc 2026 置信度 0.80
• Synthetic Biology Approaches for Optimizing Bod Degradation in Hydroponic Systems for Future Food Production
  Abstract The growing world-wide population and climate-induced agricultural setbacks demand innovative approaches to sustainable food production. Hydroponic systems offer promising solutions through resource-efficient, soilless cultivation methods suitable for…
  europepmc Oluwasanmi Anuoluwapo ADEYEMI, Bukola Margaret Popoola, Oyindamola John Samson 2026 置信度 0.80
• Synthetic biology strategies for engineering probiotics and commensal bacteria for diagnostics and therapeutics.
  europepmc 2026 置信度 0.80
• Dietary geroprotective peptides: structural determinants, AI-driven discovery, and synthetic biology production for healthy ageing.
  europepmc 2026 置信度 0.80
• [Application and prospects of synthetic biology in the genetic improvement of rice].
  europepmc 2025 置信度 0.80
• An integrated synthetic biology and robotics approach for neutralising landmines in post-war communities
  Unexploded ordnances (UXOs) and landmines endanger lives and hinder the economic progress of communities living in post-conflict zones. Currently, the primary method for clearing UXOs relies on metal detection and manual removal of UXOs - an expensive, time-co…
  europepmc Yasmin Basti, Samuel Williams, Edgar Aellen, Francesco Muci 等 2026 置信度 0.80
• A synthetic biology tool that utilizes β-estradiol to enable tight and tunable gene expression in aspergilli with a wide dynamic range
  europepmc 2026 置信度 0.80
• Recent advances in bioengineering and functional applications of microbial biocomposites: integrating bacterial cellulose, fungal mycelium and synthetic biology.
  europepmc 2026 置信度 0.80
• Synthetic Biology-Enabled Biosensing Platforms for Point-of-Care In Vitro Diagnostics: Programmable Modules, Clinical Applications, and Translational Challenges.
  Synthetic biology is reshaping in vitro diagnostics (IVD) by enabling programmable and modular biosensing elements that can be integrated into point-of-care testing (POCT) platforms. Compared with conventional assays that depend on fixed chemistries and centra…
  europepmc 2026 置信度 0.80
• Bioorthogonal and synthetic biology-engineered bacterial outer membrane vesicles for enhanced photo-immunotherapy.
  europepmc 2026 置信度 0.80