合成生物与生物制造 · 全部实体（第 78 / 100 页）

本页收录第 7701–7800 条，共 10000 条 · 返回 合成生物与生物制造 首页

• The tier system: a host development framework for bioengineering.
  europepmc 2025 置信度 0.80
• Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing.
  europepmc 2026 置信度 0.80
• Cell-free biosensor with automated acoustic liquid handling for rapid and scalable characterization of cellobiohydrolases on microcrystalline cellulose.
  europepmc 2025 置信度 0.80
• Recent developments of oleaginous yeasts toward sustainable biomanufacturing.
  europepmc Paul A Adamczyk, Tian Jiang, Karuna Jetty, Vijaydev Ganesan 等 2025 置信度 0.80
• FAST-PB: An automated plant bioengineering system for scalable genome editing and phenotyping.
  europepmc 2025 置信度 0.80
• The oleaginous yeast Rhodosporidium toruloides engineered for biomass hydrolysate-derived (E)-α-bisabolene production.
  europepmc 2025 置信度 0.80
• Author Correction: Machine learning-led semi-automated medium optimization reveals salt as key for flaviolin production in Pseudomonas putida.
  europepmc 2025 置信度 0.80
• Decoding the full chemical catalytic cycle of class I PHA synthase: A QM/MM metadynamics perspective.
  europepmc 2026 置信度 0.80
• Aromatic compound production by Corynebacterium glutamicum: unified strategies at the core and diversity by extension.
  europepmc 2025 置信度 0.80
• Perspectives for artificial intelligence in bioprocess automation.
  europepmc 2026 置信度 0.80
• ML-ABC: Machine-learning assisted Approximate Bayesian Computation for efficient calibration of agent-based models for pandemic outbreak analysis.
  europepmc 2026 置信度 0.80
• Slowpoke: An Automated Golden Gate Cloning Workflow for Opentrons OT-2 and Flex.
  europepmc 2026 置信度 0.80
• Expanding the genetic toolkit: adenine and cytosine base editors for gene disruption in Aspergillus niger.
  europepmc 2026 置信度 0.80
• Autonomous Liquid-handling Robotics Scripting for Accessible and Responsible Protein Engineering
  europepmc 2025 置信度 0.80
• Optimizing linker length of base editors for precise crop breeding and gene therapy.
  europepmc 2026 置信度 0.80
• Adaptive laboratory evolution and genetic engineering improved terephthalate utilization in Pseudomonas putida KT2440.
  europepmc 2025 置信度 0.80
• Systematic optimization of TF-based carboxylic acid biosensors in cell-free system.
  europepmc 2026 置信度 0.80
• ro-crate-rs: Development of a Lightweight RO-Crate Rust Library for Automated Synthetic Biology
  Abstract Advances in laboratory automation and AI-driven experimental design have increased the scale and complexity of data generated in synthetic biology. Whilst biofoundries provide significant resources and infrastructure to execute these experiments, most…
  europepmc Matt Burridge, Zhen Ou, Katherine James, Gizem Buldum 等 2026 置信度 0.80
• Strong Translation Elongation Factor 1-Alpha (<i>tef1α</i>) Promoter Reporter Systems for <i>Aspergillus niger</i>.
  europepmc 2025 置信度 0.80
• Genetic heterogeneity of engineered Escherichia coli Nissle 1917 strains during scale-up simulation.
  europepmc 2024 置信度 0.80
• Metabolic engineering of yeast for de novo production of kratom monoterpene indole alkaloids.
  europepmc 2024 置信度 0.80
• Production of triacetic acid lactone from oleic acid by engineering the yeast Candida viswanathii.
  europepmc 2025 置信度 0.80
• Prediction of non-intuitive metabolic targets with bayesian metabolic control analysis to improve 3-hydroxypropionic acid production in <i>Aspergillus niger</i>.
  europepmc 2026 置信度 0.80
• Thermophilic Chassis-Enabled High-Throughput Selection of a Thermostable Fluorogenic Reporter.
  europepmc 2025 置信度 0.80
• Strong segregation promotes self-destructive cooperation.
  europepmc 2025 置信度 0.80
• Supercharging engineering biology with automation.
  europepmc 2024 置信度 0.80
• Deciphering nutritional stress responses via knowledge-enriched transcriptomics for microbial engineering.
  europepmc Jongoh Shin, Daniel C. Zielinski, Bernhard O. Palsson 2024 置信度 0.80
• Enabling quantification of 2'-fucosyllactose via ligand-dependent thermal stabilization of BoGT6a.
  europepmc 2025 置信度 0.80
• BGCFlow: systematic pangenome workflow for the analysis of biosynthetic gene clusters across large genomic datasets.
  europepmc 2024 置信度 0.80
• Leveraging artificial intelligence for efficient microbial production.
  europepmc 2026 置信度 0.80
• Sphingomonas arvum sp. nov.: A promising microbial chassis for high-yield and sustainable zeaxanthin biomanufacturing.
  europepmc Chun-Zhi Jin, So Young Park, Chang-Jin Kim, Kee-Sun Shin 等 2024-10-30T02:59:42Z 置信度 0.80
• Establishing BioE3 centres: catalyzing India's biomanufacturing transformation.
  India’s bioeconomy is poised for rapid expansion, targeting a valuation of $300 billion by 2030. The recently approved BioE3 Policy (Biotechnology for Economy, Environment, and Employment) aims to reposition India as a global leader in sustainable, high-perfor…
  europepmc Dhiraj Kumar, Jitendra Kumar 2025 置信度 0.80
• How to get the most out of fungal biotechnology?
  europepmc 2026 置信度 0.80
• A decade of translational engineering biology: Measuring success.
  europepmc 2024 置信度 0.80
• Mass Spectrometric Screening for Improving Enzymatic Conversion of Formaldehyde into C2 and C3 Products.
  europepmc 2025 置信度 0.80
• Automated Genetic Manipulation for the Construction of <i>Pichia pastoris</i> Cell Factories.
  europepmc 2025 置信度 0.80
• A Generalized Platform for Artificial Intelligence-powered Autonomous Protein Engineering
  europepmc 2025 置信度 0.80
• Applying the design-build-test-learn framework to precision fermentation for sustainable food ingredients.
  Precision fermentation enables the sustainable synthesis of value-added products by engineering microorganisms into specialized cell factories. Unlike traditional fermentation, food-grade precision fermentation operates within a highly regulated framework rela…
  pubmed Shin J 2026 Aug 置信度 0.82
• Converging quality by design, artificial intelligence, and biofoundry automation: A new paradigm for scalable circular biomanufacturing.
  Synthetic biology applies engineering principles to the rational design of biological systems with the aim of producing predictable and tunable behaviour. Although the field's conceptual foundations and core technologies are well established, the recent simult…
  pubmed Belloch-Molina C, da Silva FVS, Morrissey JP, Gallagher MS 2026 Jul 30 置信度 0.82
• Glyco you should know.
  pubmed Tiwari M 2026 Jul 30 置信度 0.82
• Protein engineering: Status report.
  With this status report, we aim to provide a timely snapshot of the protein engineering field as a broad and rapidly advancing discipline that integrates computational, molecular biology, structure-guided, evolutionary, and synthetic approaches to create new a…
  pubmed Ai HW, Arnold FH, Barrick D, Bayley H 等 2026 Jul 17 置信度 0.82
• Functional redundancy driven by isocitrate dehydrogenase enhances metabolic robustness in Pseudomonas putida KT2440.
  Prokaryotic isocitrate dehydrogenase (PIDH) is a conserved and highly versatile enzyme regulating carbon flux between the TCA cycle and the glyoxylate shunt. While most mesophilic organisms encode a single PIDH, the industrial chassis Pseudomonas putida KT2440…
  pubmed Manoli MT, Alarcon SH, Gargantilla-Becerra Á, Prieto MA 等 2026 Jul 16 置信度 0.82
• Building Bridges: A Story of How Institutional Investment in Discipline-Based Education Research Enables Evidence-Based Teaching in Biochemistry Education.
  Scientific discoveries often advance more rapidly than they are integrated into undergraduate instruction, leaving emerging fields like glycoscience largely absent from classroom curricula. At the University of Georgia, institutional investment in discipline-b…
  pubmed Tiwari M, Dolan EL 2026 Jul 16 置信度 0.82
• Artificial intelligence and automation in enzyme engineering: evolution, advances, and future perspectives.
  Natural enzymes often fail to meet industrial demands for catalytic efficiency, stability, and substrate specificity, creating a critical bottleneck in biomanufacturing. This review examines how artificial intelligence (AI) and automation are reshaping enzyme …
  pubmed Hao K, Liu J, Tang H, Zhang Y 等 2026 Jul 10 置信度 0.82
• Automated Genetic Engineering in the Laboratory.
  In today's rapidly evolving research landscape, improving experimental throughput and reproducibility are essential. Furthermore, given that biological systems are dependent on many variables, stepwise optimization is not an efficient or effective method for e…
  pubmed Li Z, Young EM 2026 置信度 0.82
• Vision and Development of a Design, Implementation, and Verification Automation (DIVA) Software Platform for DNA Construction.
  DNA construction, while a prerequisite to many biological endeavors, is often a time-consuming distraction from an individual's primary research objectives. We envisioned that with the right software infrastructure and cultural mindset, a single person could e…
  pubmed Plahar H, Lane SD, Stawski N, Simirenko L 等 2026 Jul 7 置信度 0.82
• Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing.
  CRISPR-based prime editors (PEs) install precise edits into genomic DNA without generating double-strand breaks. Their editing efficiency is highly dependent on reverse transcriptases (RTs), but efficient RT candidates remain limited. Here, we identified 19 no…
  pubmed Ma L, Yao P, Wu S, Shi Y 等 2026 Jun 26 置信度 0.82
• Engineering and Application of a Thermostable MHETase for PET Depolymerization.
  Enzymatic hydrolysis of poly-(ethylene terephthalate) (PET) releases mono-(2-hydroxyethyl) terephthalate (MHET) as a major product, the accumulation of which can prolong reactor residence times and complicate downstream monomer separations. The use of a MHETas…
  pubmed Murphy NP, Gado JE, Neumann T, Perez-Garcia P 等 2026 Jun 22 置信度 0.82
• Protocol for connector-enabled multigene pathway assembly using Golden Gate Assembly and yeast recombination.
  Here, we present a protocol for multigene pathway construction in Saccharomyces cerevisiae using a connector-enabled workflow that integrates Golden Gate Assembly with yeast homologous recombination. We provide procedures for assembling Level 1 transcriptional…
  pubmed Seong MJ, Shin J, Lee DH 2026 Jun 19 置信度 0.82
• Unveiling Candidate Markers for Drug Resistance or Synthetic Lethality in Cervical Cancer: Integrative Analysis of Genetic and Pharmacoprofiling.
  Systemic cervical cancer management continues to be challenging. Numerous chemotherapies have been approved, but predicting response is difficult due to the lack of biomarkers. Here, we analyze the genetic and protein profiles of 20 cervical cancer cell lines …
  pubmed Scholl S, Nery ED, Gestraud P, Halladjian M 等 2026 Jun 置信度 0.82
• Investigating the gut microbiota in advanced heart failure and cardiac cachexia.
  Cardiac cachexia (CC) is associated with advanced heart failure (AHF), characterized by unintentional weight loss (UWL) of fat/muscle. It is exacerbated by right ventricular systolic dysfunction (RVSD). The potential pathogenic role of gut microbiota (GM) chan…
  pubmed Dulay MS, Chrysostomou D, Campos M, Storch M 等 2026 置信度 0.82
• Cell Factory Engineering
  crossref Anne Mathilde Davy, Helene Faustrup Kildegaard, Mikael Rørdam Andersen 2017-03-22T17:36:11Z 置信度 0.70
• Optimal surface topography for cell adhesion is driven by cell membrane mechanics
  Titanium surface treated with titanium oxide nanotubes was used in many studies to quantify the effect of surface topography on cell fate. However, the predicted optimal diameter of nanotubes considerably differs among studies. We propose a model that explain …
  arxiv Matej Daniel, Kristina Eleršič Filipič, Eva Filová, Jaroslav Fojt 2020-06-30T13:43:37Z 置信度 0.78 q-bio.CBphysics.bio-ph
• Modeling cell migration regulated by cell-ECM micromechanical coupling
  Cell migration in fibreous extracellular matrix (ECM) is crucial to many physiological and pathological processes such as tissue regeneration, immune response and cancer progression. During migration, individual cells can generate active pulling forces via act…
  arxiv Yu Zheng, Hanqing Nan, Qihui Fan, Xiaochen Wang 等 2019-05-16T18:03:48Z 置信度 0.78 q-bio.CBcond-mat.softphysics.bio-ph
• Spatial dynamic modelling to understand how dendritic cell clustering affects T cell activation
  The coordination of the immune system and its components is essential for the body to maintain a healthy status. Recent clinical studies show that breast cancer patients with high Dendritic cell clustering in tumour draining lymph nodes have improved survival …
  arxiv Domenic P. J. Germano, Federico Frascoli, Robyn P. Araujo, Peter P. Lee 等 2026-04-20T04:20:29Z 置信度 0.78 q-bio.CB
• Cell adhesion and cortex contractility determine cell patterning in the Drosophila retina
  Hayashi and Carthew (Nature 431 [2004], 647) have shown that the packing of cone cells in the Drosophila retina resembles soap bubble packing, and that changing E- and N-cadherin expression can change this packing, as well as cell shape. The analogy with bubbl…
  arxiv Jos Käfer, Takashi Hayashi, Athanasius F. M. Marée, Richard W. Carthew 等 2007-05-08T09:51:02Z 置信度 0.78 q-bio.CBq-bio.TO
• High expression of antioxidant proteins in dendritic cells: possible implications in atherosclerosis
  Dendritic cells (DCs) display the unique ability to activate naive T cells and to initiate primary T cell responses revealed in DC-T cell alloreactions. DCs frequently operate under stress conditions. Oxidative stress enhances the production of inflammatory cy…
  arxiv Aymeric Rivollier, Laure Perrin-Cocon, Sylvie Luche, Hélène Diemer 等 2006-11-24T09:03:01Z 置信度 0.78 q-bio.GN
• Nearby Supernova Factory Observations of SN 2006D: On Sporadic Carbon Signatures in Early Type Ia Supernova Spectra
  We present four spectra of the Type Ia supernova (SN Ia) 2006D extending from -7 to +13 days with respect to B-band maximum. The spectra include the strongest signature of unburned material at photospheric velocities observed in a SN Ia to date. The earliest s…
  arxiv The Nearby Supernova Factory, :, R. C. Thomas, G. Aldering 等 2006-11-10T23:27:41Z 置信度 0.78 astro-ph
• Criticality in Cell Differentiation
  Cell differentiation is an important process in living organisms. Differentiation is mostly based on binary decisions with the progenitor cells choosing between two specific lineages. The differentiation dynamics have both deterministic and stochastic componen…
  arxiv Indrani Bose, Mainak Pal 2016-12-23T08:04:10Z 置信度 0.78 q-bio.CB
• Cell-cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis
  Collective cell responses to exogenous cues depend on cell-cell interactions. In principle, these can result in enhanced sensitivity to weak and noisy stimuli. However, this has not yet been shown experimentally, and, little is known about how multicellular si…
  arxiv David Ellison, Andrew Mugler, Matthew Brennan, Sung Hoon Lee 等 2015-08-19T16:25:18Z 置信度 0.78 q-bio.CB
• Cell-Type Modular Plant Factory (V 4)
  crossref Yoshikazu Nishida, Nobuaki Okada 2018-10-19T17:48:04Z 置信度 0.70
• 8 Microalgae – the solar cell factory
  crossref Clemens Posten 2019-10-17T08:30:09Z 置信度 0.70
• Cell Controllers: Factory Automation Building Blocks
  crossref 2013-11-18T01:23:45Z 置信度 0.70
• Yarrowia lipolytica as a Cell Factory for Oleochemical Biotechnology
  crossref 2012-02-02T11:26:35Z 置信度 0.70
• The new tissue and cell factory Turin Skin Bank
  crossref Irene Cambieri 2020-02-19T15:28:36Z 置信度 0.70
• Modeling and simulation of hybrid systems and cell factory applications
  Les fonctions biologiques sont le résultat de l'interaction de beaucoup de processus, avec différents objectifs, complexités, niveaux de hiérarchie, et changements de conditions que modifient le comportement de systèmes. Nous utilisons des équations différenti…
  crossref Rodrigo Assar Cuevas 2026-03-30T15:01:09Z 置信度 0.70
• Aspergillus : A Cell Factory with Unlimited Prospects
  crossref 2013-07-16T17:45:04Z 置信度 0.70
• Engineering a Yeast Cell Factory to Sustainably Biosynthesize Parthenolide
  crossref 2025-03-06T22:30:11Z 置信度 0.70
• Machine Combination Analysis Procedure for Selecting Optimal Factory Cell Composition
  This research examined the relationship between manufacturing input parameters and factory performance in a cellular manufacturing environment.
  crossref J. Robert McQuaid 2026-04-12T05:23:38Z 置信度 0.70
• Compensation Systems for Cell Employees
  crossref 2020-11-18T23:44:33Z 置信度 0.70
• Selecting and Training Cell Employees
  crossref 2020-11-18T18:44:33Z 置信度 0.70
• Understanding Cell Performance Using Modeling
  crossref 2020-11-18T23:44:33Z 置信度 0.70
• Desenvolvimento de uma cell factory a partir do fungo termofílico Thermothielavioides terrestris
  crossref Awana da Silva Lima 2024-12-12T13:49:06Z 置信度 0.70
• 8. Microalgae – the solar cell factory
  crossref 2018-04-11T18:13:27Z 置信度 0.70
• Pseudomonas
  crossref 2008-04-22T09:47:24Z 置信度 0.70
• The cell factory needs a model of a factory
  crossref Marco L.F Giuseppin, C.Theo Verrips, Natal A.W van Riel 2002-07-25T13:40:30Z 置信度 0.70
• The bag or the spindle: the cell factory at the time of systems' biology
  Abstract Genome programs changed our view of bacteria as cell factories, by making them amenable to systematic rational improvement. As a first step, isolated genes (including those of the metagenome), or small gene clusters are improved and expressed in a var…
  crossref Antoine Danchin 2004-11-16T07:24:20Z 置信度 0.70
• Saccharomyces cerevisiae as a microbial cell factory
  crossref Ryosuke Mitsui, Ryosuke Yamada 2021-03-09T05:42:56Z 置信度 0.70
• On-Line Control Reconfiguration at the Machine and Cell Levels: Case Studies from the Reconfigurable Factory Testbed
  crossref J.E. Luntz, J.R. Moyne, D.M. Tilbury 2006-04-07T00:21:22Z 置信度 0.70
• Development and Perspective of Rhodotorula toruloides as an Efficient Cell Factory
  crossref 2023-01-23T11:10:19Z 置信度 0.70
• Post-production protein stability: trouble beyond the cell factory
  Abstract Being protein function a conformation-dependent issue, avoiding aggregation during production is a major challenge in biotechnological processes, what is often successfully addressed by convenient upstream, midstream or downstream approaches. Even whe…
  crossref Esther Vazquez, José Luis Corchero, Antonio Villaverde 2011-08-02T18:18:50Z 置信度 0.70
• MicroRNA Factory: RISC Assembly from Precursor MicroRNAs
  crossref Yoosik Kim, V. Narry Kim 2012-05-24T17:53:39Z 置信度 0.70
• Detailed Planning—One Cell at a Time
  crossref 2020-11-18T23:44:33Z 置信度 0.70
• From model factory to modern factory
  Initiatives to make gardens and parks at factories were a part of the wider public health and urban planning reforms taking place in the late nineteenth and early twentieth centuries. In landscaping their factories and providing recreation space, industrialist…
  crossref Helena Chance 2017-09-23T14:24:12Z 置信度 0.70
• Computer-Based Design of a Cell Factory for High-Yield Cytidine Production
  crossref 2022-11-28T17:50:15Z 置信度 0.70
• In and out of the Replication Factory
  crossref Peter Meister, Angela Taddei, Susan M. Gasser 2006-07-01T09:40:19Z 置信度 0.70
• Melanoma Cell Factory for Glycolipid Production
  crossref Maria Carmelita Z. Kasuya, Kenichi Hatanak 2012-05-17T14:06:16Z 置信度 0.70
• Development of a Rhodococcus opacus Cell Factory for Valorizing Lignin to Muconate
  crossref 2020-04-07T07:02:58Z 置信度 0.70
• Smart Factory Cell
  Internet of Things (IoT), Industrie 4.0, wandelbare Fabrik – dies sind gern und häufig benutzte Schlagwörter für eine Vielzahl an Gedanken und Interpretationen. Viele davon betreffen die Messtechnik und erwarten von ihr zukunfts- und tragfähige Automatisierung…
  crossref Patric Sand 2023-08-02T09:59:17Z 置信度 0.70
• Toward Developing a Yeast Cell Factory for the Production of Prenylated Flavonoids
  crossref 2020-04-09T10:19:08Z 置信度 0.70
• SYNTHETIC BIOLOGY APPROACHES FOR MAMMALIAN CELL FACTORY ENGINEERING
  The production of high-quality recombinant proteins is critical to maintaining a continuous supply of biopharmaceuticals, such as therapeutic antibodies. Engineering mammalian cell factories presents a number of limitations typically associated with proteotoxi…
  preprints Laura Segatori, Bhagyashree Bachhav, Jacopo de Rossi, Carlos D. Llanos 2022 置信度 0.74
• Nutraceuticals Production from Plant Cell Factory
  crossref 2022-06-22T16:37:07Z 置信度 0.70
• Scientists Ratchet Up Understanding of Cellular Protein Factory
  crossref . . 2020-10-19T07:24:10Z 置信度 0.70
• Developing Escherichia coli MG1655 as a Microbial Cell Factory for Sustainable Gadusol Biosynthesis
  crossref 2026-04-02T02:30:11Z 置信度 0.70
• CF-Targeter: A Rational Biological Cell Factory Targeting Platform for Biosynthetic Target Chemicals
  crossref 2020-04-08T05:43:18Z 置信度 0.70
• Establishing Komagataella phaffii as a Cell Factory for Efficient Production of Cholesterol Sulfate
  crossref 2024-12-23T01:30:27Z 置信度 0.70
• Planning for Cell Implementation and Managing the Change
  crossref 2020-11-18T18:44:33Z 置信度 0.70
• Yeast cell factory: fishing for the best one or engineering it?
  crossref Danilo Porro, Paola Branduardi 2009-10-13T06:18:49Z 置信度 0.70
• Systems-level approaches for understanding and engineering of the oleaginous cell factory Yarrowia lipolytica
  Concerns about climate change and the search for renewable energy sources together with the goal of attaining sustainable product manufacturing have boosted the use of microbial platforms to produce fuels and high-value chemicals. In this regard, Y. lipolytica…
  crossref Naghmeh Poorinmohammad, Eduard Kerkhoven 2020-10-19T20:12:17Z 置信度 0.70
• Less Is More: Toward a Genome-Reduced Bacillus Cell Factory for Difficult Proteins
  crossref 2020-04-10T08:18:55Z 置信度 0.70