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• [Research progress in inducible expression regulation systems in photosynthetic cyanobacteria].
  Cyanobacteria, as a group of prokaryotic photosynthetic microorganisms, have recently garnered widespread attention in the fields of synthetic biology and green biomanufacturing due to their ability to utilize light energy and carbon dioxide for autotrophic gr…
  pubmed Zhu L, Dong Z, Chen L, Sun T 等 2026 置信度 0.82
• Cofactor engineering powers next-generation biomanufacturing.
  europepmc Zhiyi Lu, Zushuang Zhang, Peng Chen, Qing Xu 等 2026 置信度 0.80
• Stress physiology and matrix-mediated delivery of probiotic microorganisms: translational challenges and strategies for industrial biomanufacturing.
  Achieving reproducible probiotic performance under industrial manufacturing conditions remains a central unresolved challenge in applied microbial biotechnology. Despite substantial investment in strain development and formulation technologies, commercially pr…
  pubmed Sengupta A, Maji P, Ghosh S, Shukla P 等 2026 置信度 0.82
• Mutations in AtpB and LexA confer temperature tolerance in an evolved Synechocystis sp. PCC 6803 strain resistant to high temperature and light.
  europepmc 2026 置信度 0.80
• Biocatalysis and biodegradation for efficient utilization of liquid n-alkanes.
  europepmc 2026 置信度 0.80
• Oosporein in Phlebia centrifuga: Prediction of Key Enzymes by a Combination of Multi-Omics and Molecular Dynamics.
  europepmc 2026 置信度 0.80
• Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels
  cells/ml. Organ building blocks (OBBs) composed of patient-specific-induced pluripotent stem cell-derived organoids offer a pathway to achieving tissues with the requisite cellular density, microarchitecture, and function. However, to date, scant attention has…
  openalex Mark A. Skylar‐Scott, Sebastien G. M. Uzel, Lucy Nam, John H. Ahrens 等 2019-09-06 置信度 0.72 BiomanufacturingComputer scienceComputational biologyBiologyGenetics
• Industrial biomanufacturing: The future of chemical production
  The current model for industrial chemical manufacturing employs large-scale megafacilities that benefit from economies of unit scale. However, this strategy faces environmental, geographical, political, and economic challenges associated with energy and manufa…
  openalex James M. Clomburg, Anna Morgan Crumbley, Ramón González, Anna M. Crumbley 等 2017-01-05 置信度 0.72 BiomanufacturingScale (ratio)Biochemical engineeringProcess (computing)Software deployment
• Biomanufacturing: history and perspective
  Biomanufacturing is a type of manufacturing that utilizes biological systems (e.g., living microorganisms, resting cells, animal cells, plant cells, tissues, enzymes, or in vitro synthetic (enzymatic) systems) to produce commercially important biomolecules for…
  openalex Y.‐H. Percival Zhang, Jibin Sun, Yanhe Ma 2016-11-11 置信度 0.72 BiomanufacturingBiotechnologyBiologyMetabolic engineeringBiochemistry
• A microbial biomanufacturing platform for natural and semisynthetic opioids
  openalex Kate Thodey, Stephanie Galanie, Christina D. Smolke 2014-08-24 置信度 0.72 BenzylisoquinolineBiomanufacturingYeastHydrocodoneThebaine
• Biomanufacturing for clinically advanced cell therapies
  openalex Ayesha Aijaz, Matthew Li, David Smith, Danika Khong 等 2018-06-04 置信度 0.72 BiomanufacturingBioprocessCell therapyChimeric antigen receptorMedicine
• Photosynthetic biomanufacturing in green algae; production of recombinant proteins for industrial, nutritional, and medical uses
  openalex Beth A. Rasala, Stephen P. Mayfield 2014-03-21 置信度 0.72 BiomanufacturingChlamydomonas reinhardtiiBiologyRecombinant DNAMutagenesis
• The business impact of an integrated continuous biomanufacturing platform for recombinant protein production
  openalex Jason Walther, Rahul Godawat, Chris Hwang, Yuki Abe 等 2015-05-25 置信度 0.72 BiomanufacturingContinuous productionPortfolioBioprocessComputer science
• Trends in the biomanufacture of polyhydroxyalkanoates with focus on downstream processing
  openalex Maria R. Kosseva, Edy Rusbandi 2017-09-19 置信度 0.72 PolyhydroxyalkanoatesBiomass (ecology)Downstream processingFermentationDownstream (manufacturing)
• Insect cells as factories for biomanufacturing
  openalex Jean‐Christophe Drugmand, Yves‐Jacques Schneider, Spiros N. Agathos 2011-10-02 置信度 0.72 BiomanufacturingBiologyHeterologousBiotechnologyComputational biology
• The duckweeds: A valuable plant for biomanufacturing
  openalex Anne-Marie Stomp 2005-01-01 置信度 0.72 BiomanufacturingBioproductionCommercializationBiotechnologyBiology
• New biotechnology paradigm: cell-free biosystems for biomanufacturing
  Cost-efficient production of sustainably-derived biochemicals and biofuels is a critical goal of modern biotechnology. The current predominant biotransformation method is mainly based on microbial fermentation, but this system suffers from a mismatch of engine…
  openalex Joseph A. Rollin, Tsz Kin Tam, Y.‐H. Percival Zhang 2013-01-01 置信度 0.72 BiomanufacturingBiochemical engineeringSynthetic biologyFermentationMetabolic engineering
• Biomanufacturing for tissue engineering: Present and future trends
  Tissue engineering, often referred to as regenerative medicine and reparative medicine, is an interdisciplinary field that necessitates the combined effort of cell biologists, engineers, material scientists, mathematicians, geneticists, and clinicians toward t…
  openalex Paulo Bártolo, Chee Kai Chua, Henrique A. Almeida, Siaw Meng Chou 等 2009-12-01 置信度 0.72 BiomanufacturingTissue engineeringRegenerative medicineScaffoldNanotechnology
• Microbial consortia: a critical look at microalgae co-cultures for enhanced biomanufacturing
  Monocultures have been the preferred production route in the bio-industry, where contamination has been a major bottleneck. In nature, microorganisms usually exist as part of organized communities and consortia, gaining benefits from co-habitation, keeping inv…
  openalex Gloria Padmaperuma, Rahul Vijay Kapoore, D. James Gilmour, Seetharaman Vaidyanathan 2017-12-12 置信度 0.72 BiomanufacturingContext (archaeology)BottleneckBusinessBiochemical engineering
• Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing
  openalex Róisín O’Flaherty, Adam Bergin, Evangelia Flampouri, Letícia Martins Mota 等 2020-05-13 置信度 0.72 BiomanufacturingBiopharmaceuticalDownstream (manufacturing)Biochemical engineeringProcess development
• Uncorking the biomanufacturing bottleneck
  openalex Alan Dove 2002-08-01 置信度 0.72 BiomanufacturingBottleneckBusinessBiotechnologyBiology
• Cell-free biomanufacturing
  openalex Bradley C. Bundy, J. Porter Hunt, Michael C. Jewett, James R. Swartz 等 2018-11-13 置信度 0.72 BiomanufacturingDECIPHERBiochemical engineeringSynthetic biologyMetabolic engineering
• Biomaterials for stem cell engineering and biomanufacturing
  Recent years have witnessed the expansion of tissue failures and diseases. The uprising of regenerative medicine converges the sight onto stem cell-biomaterial based therapy. Tissue engineering and regenerative medicine proposes the strategy of constructing sp…
  openalex Yibo Xu, Chuanxin Chen, Peter B. Hellwarth, Xiaoping Bao 2019-12-01 置信度 0.72 BiomanufacturingStem cellRegenerative medicineInduced pluripotent stem cellTissue engineering
• An in vitro synthetic biology platform for the industrial biomanufacturing of myo‐inositol from starch
  ABSTRACT Myo‐Inositol (vitamin B8) is widely used in the drug, cosmetic, and food & feed industries. Here, we present an in vitro non‐fermentative enzymatic pathway that converts starch to inositol in one vessel. This in vitro pathway is comprised of four …
  openalex Chun You, Ting Shi, Yunjie Li, Pingping Han 等 2017-04-14 置信度 0.72 BiomanufacturingInositolIn vitroSynthetic biologyStarch
• Polylactides in additive biomanufacturing
  openalex Patrina S. P. Poh, Mohit P. Chhaya, Felix M. Wunner, Elena M. De‐Juan‐Pardo 等 2016-08-02 置信度 0.72 BiomanufacturingManufacturing engineering3D printingEngineeringNanotechnology
• Extracellular vesicles: exosomes, microparticles, their parts, and their targets to enable their biomanufacturing and clinical applications
  openalex Chen‐Yuan Kao, Eleftherios T. Papoutsakis 2019-03-06 置信度 0.72 BiomanufacturingMicrovesiclesExtracellular vesiclesExtracellular vesicleExosome
• Rheological behavior of alginate solutions for biomanufacturing
  Abstract The rheological behavior of alginate solutions were investigated for the optimal design of a biomanufacturing system to produce alginate structures for tissue engineering. Its rheological properties were determined by a rheometer through rotational an…
  openalex Rodrigo Alvarenga Rezende, Paulo Bártolo, Ausenda Mendes, Rubens Maciel Filho 2009-05-27 置信度 0.72 RheologyRheometerBiomanufacturingMaterials scienceShear modulus
• Synthetic Methylotrophy: A Practical Solution for Methanol-Based Biomanufacturing
  openalex Yu Wang, Liwen Fan, Philibert Tuyishime, Ping Zheng 等 2020-01-10 置信度 0.72 BioproductionSynthetic biologyMethanolBiomanufacturingBiochemical engineering
• Synthetic biology of extremophiles: a new wave of biomanufacturing
  openalex Jianwen Ye, Yi-Na Lin, Xueqing Yi, Zhuo-Xuan Yu 等 2022-12-17 置信度 0.72 BiomanufacturingSynthetic biologyExtremophileIndustrial biotechnologyBiochemical engineering
• Large-scale cultured meat production: Trends, challenges and promising biomanufacturing technologies
  openalex Chen D. Lu, Donovan Guttieres, Andrea Koenigsberg, Paul W. Barone 等 2021-11-24 置信度 0.72 BiomanufacturingBioprocessSustainabilityBusinessProduction (economics)
• Co-culturing microbial consortia: approaches for applications in biomanufacturing and bioprocessing
  The application of microbial co-cultures is now recognized in the fields of biotechnology, ecology, and medicine. Understanding the biological interactions that govern the association of microorganisms would shape the way in which artificial/synthetic co-cultu…
  openalex Rahul Vijay Kapoore, Gloria Padmaperuma, Supattra Maneein, Seetharaman Vaidyanathan 2021-05-12 置信度 0.72 BiomanufacturingBioprocessBiochemical engineeringEnablingBiotechnology
• On-demand biomanufacturing of protective conjugate vaccines
  challenge. The iVAX platform promises to accelerate development of new conjugate vaccines with increased access through refrigeration-independent distribution and portable production.
  openalex Jessica C. Stark, Thapakorn Jaroentomeechai, Tyler D. Moeller, Jasmine M. Hershewe 等 2021-02-03 置信度 0.72 ConjugateFrancisella tularensisBiomanufacturingEscherichia coliMicrobiology
• Additive Biomanufacturing: An Advanced Approach for Periodontal Tissue Regeneration
  Periodontitis is defined as a chronic inflammatory condition, characterized by destruction of the periodontium, composed of hard (i.e. alveolar bone and cementum) and soft tissues (i.e. gingiva and periodontal ligament) surrounding and supporting the teeth. In…
  openalex Sarah-Sophia D. Carter, Pedro F. Costa, Cédryck Vaquette, Sašo Ivanovski 等 2016-07-29 置信度 0.72 BiomanufacturingPeriodontologyPeriodontiumCementumScaffold
• Toward sustainable, cell-free biomanufacturing
  openalex Blake J. Rasor, Bastian Vögeli, Grant M. Landwehr, Jonathan W. Bogart 等 2021-01-13 置信度 0.72 BiomanufacturingScope (computer science)Biochemical engineeringSustainable productionProduction (economics)
• Biomanufacturing
  openalex Mamoru Mitsuishi, Jian Cao, Paulo Bártolo, Dirk Friedrich 等 2013-01-01 置信度 0.72 BiomanufacturingBiofabricationEngineeringManufacturing engineeringEngineering management
• Transformation of Breast Reconstruction via Additive Biomanufacturing
  Adipose tissue engineering offers a promising alternative to current breast reconstruction options. However, the conventional approach of using a scaffold in combination with adipose-derived precursor cells poses several problems in terms of scalability and he…
  openalex Mohit P. Chhaya, Elizabeth R. Balmayor, Dietmar W. Hutmacher, Jan‐Thorsten Schantz 2016-06-15 置信度 0.72 Adipose tissueScaffoldBiomanufacturingRegeneration (biology)Biomedical engineering
• The need for innovation in biomanufacturing
  openalex Uwe Gottschalk, Kurt Brorson, Abhinav Shukla, Abhinav A Shukla 2012-06-01 置信度 0.72 BiomanufacturingBusinessComputational biologyBiotechnologyBiology
• Biomanufacturing of Tomato-Derived Nanovesicles
  Micro- and nano-sized vesicles (MVs and NVs, respectively) from edible plant resources are gaining increasing interest as green, sustainable, and biocompatible materials for the development of next-generation delivery vectors. The isolation of vesicles from co…
  openalex B. Ramesh, Anna Paulina Ramos, Immacolata Fiume, Mauro Manno 等 2020-12-11 置信度 0.72 VesicleSolanumChromoplastUltracentrifugeSize-exclusion chromatography
• Biomanufacturing of CdS quantum dots
  A strain of Stenotrophomonas maltophilia is engineered to achieve size controlled synthesis of water soluble CdS quantum dots.
  openalex Yang Zhou, L. W. Lu, Victoria F. Berard, Qian He 等 2015-01-01 置信度 0.72 Quantum dotBiomanufacturingStenotrophomonas maltophiliaNanotechnologyChemistry
• Digital Twin in biomanufacturing: challenges and opportunities towards its implementation
  openalex Isuru A. Udugama, Pau Cabañeros López, Carina L. Gargalo, Xueliang Li 等 2021-03-01 置信度 0.72 BiomanufacturingProcess (computing)Computer scienceKey (lock)Resource (disambiguation)
• Plant Molecular Farming – Integration and Exploitation of Side Streams to Achieve Sustainable Biomanufacturing
  Plants have unique advantages over other systems such as mammalian cells for the production of valuable small molecules and proteins. The benefits cited most often include safety due to the absence of replicating human pathogens, simplicity because sterility i…
  openalex Johannes F. Buyel 2019-01-18 置信度 0.72 BiomanufacturingAgricultureSustainable agricultureSTREAMSBiotechnology
• Aqueous two-phase extraction as a platform in the biomanufacturing industry: Economical and environmental sustainability
  openalex P.A.J. Rosa, Ana M. Azevedo, Sven D. Sommerfeld, W. Bäcker 等 2011-04-20 置信度 0.72 Downstream processingBiomanufacturingBottleneckBiotechnologySustainability
• Towards smart biomanufacturing: a perspective on recent developments in industrial measurement and monitoring technologies for bio-based production processes
  The biomanufacturing industry has now the opportunity to upgrade its production processes to be in harmony with the latest industrial revolution. Technology creates capabilities that enable smart manufacturing while still complying with unfolding regulations. …
  openalex Carina L. Gargalo, Isuru A. Udugama, Katrin Pontius, Pau Cabañeros López 等 2020-09-07 置信度 0.72 BiomanufacturingBiochemical engineeringProduction (economics)Perspective (graphical)Smart manufacturing
• Biomanufacturing, from bust to boom...to bubble?
  openalex Karl A Thiel 2004-11-01 置信度 0.72 BiomanufacturingBoomBustEconomic shortageBusiness
• Engineered Methanotrophy: A Sustainable Solution for Methane-Based Industrial Biomanufacturing
  openalex Anh Duc Nguyen, Eun Yeol Lee 2020-08-19 置信度 0.72 BiomanufacturingMethaneBioconversionMetabolic engineeringBiochemical engineering
• Epsilon-poly-L-lysine: Recent Advances in Biomanufacturing and Applications
  ε-poly-L-lysine (ε-PL) is a naturally occurring poly(amino acid) of varying polymerization degree, which possesses excellent antimicrobial activity and has been widely used in food and pharmaceutical industries. To provide new perspectives from recent advances…
  openalex Liang Wang, Chongyang Zhang, Jianhua Zhang, Zhiming Rao 等 2021-09-28 置信度 0.72 BiomanufacturingCommercializationBiochemical engineeringBiotechnologyComputational biology
• Additive Biomanufacturing with Collagen Inks
  Collagen is a natural polymer found abundantly in the extracellular matrix (ECM). It is easily extracted from a variety of sources and exhibits excellent biological properties such as biocompatibility and weak antigenicity. Additionally, different processes al…
  openalex Weng Wan Chan, David Yeo, Vernice Tan, Satnam Singh 等 2020-07-01 置信度 0.72 BiomanufacturingBiomaterialBiocompatibilityRegenerative medicineExtracellular matrix
• Prospects for carbon-negative biomanufacturing
  Biomanufacturing has the potential to reduce demand for petrochemicals and mitigate climate change. Recent studies have also suggested that some of these products can be net carbon negative, effectively removing CO 2 from the atmosphere and locking it up in pr…
  openalex Corinne D. Scown 2022-10-01 置信度 0.72 BiomanufacturingPetrochemicalCarbon fibersCarbon sequestrationGreenhouse gas
• Natural Extracellular Matrix for Cellular and Tissue Biomanufacturing
  Natural extracellular matrices (ECM) derived from native tissues or cultured cells are extensively employed to fabricate biocompatible scaffolds or living tissue constructs for the application in cellular and tissue engineering. The composition and structure o…
  openalex Qi Xing, Zichen Qian, Wenkai Jia, Avik Ghosh 等 2016-12-06 置信度 0.72 BiomanufacturingExtracellular matrixTissue engineeringScaffoldSelf-healing hydrogels
• Continuous biomanufacturing with microbes — upstream progresses and challenges
  openalex Dongming Xie 2022-09-08 置信度 0.72 BiomanufacturingBiochemical engineeringBiotechnologyEngineeringComputer science
• Automated engineering of synthetic metabolic pathways for efficient biomanufacturing
  openalex Irene Otero‐Muras, Pablo Carbonell, Irene Otero-Muras 2020-12-13 置信度 0.72 BiomanufacturingMetabolic engineeringSynthetic biologyBiochemical engineeringComputer science
• Proteomic and Metabolic Elucidation of Solar-Powered Biomanufacturing by Bio-Abiotic Hybrid System
  openalex Rutan Zhang, Ying He, Yi Jia, Lijuan Zhang 等 2019-11-28 置信度 0.72 BiomanufacturingAbiotic componentComputational biologyBiologyMetabolomics
• Kinetic Modeling of Mammalian Cell Culture Bioprocessing: The Quest to Advance Biomanufacturing
  Kinetic modeling is the most suitable framework to describe the dynamic behavior of mammalian cell culture although its industrial application is still in its infancy. Herein, the authors reviewed mammalian bioprocess relevant kinetic models, and found that th…
  openalex Sarantos Kyriakopoulos, Kok Siong Ang, Meiyappan Lakshmanan, Zhuangrong Huang 等 2017-10-13 置信度 0.72 BiomanufacturingBioprocessBioprocess engineeringBiochemical engineeringChemistry
• A common framework for integrated and continuous biomanufacturing
  There is a growing application of integrated and continuous bioprocessing (ICB) for manufacturing recombinant protein therapeutics produced from mammalian cells. At first glance, the newly evolved ICB has created a vast diversity of platforms. A closer inspect…
  openalex Jon Coffman, Mark Brower, Lisa Connell‐Crowley, Sevda Deldari 等 2021-01-25 置信度 0.72 BiomanufacturingFlexibility (engineering)Adaptation (eye)BiopharmaceuticalBioprocess
• Towards rationally designed biomanufacturing of therapeutic extracellular vesicles: impact of the bioproduction microenvironment
  openalex Divya Patel, Marco Santoro, Louis J. Born, John P. Fisher 等 2018-09-12 置信度 0.72 BiomanufacturingBioproductionMicrovesiclesSpinal cord injuryExtracellular vesicles
• C1-based biomanufacturing: Advances, challenges and perspectives
  openalex Xueqin Lv, Wenwen Yu, Chenyang Zhang, Peng Ning 等 2022-11-05 置信度 0.72 BiomanufacturingSynthetic biologyBiochemical engineeringMetabolic engineeringBiotechnology
• Continuous Biomanufacturing ‐ Innovative Technologies and Methods
  openalex G. Subramanian, Ganapathy Subramanian 2017-10-18 置信度 0.72 BiomanufacturingComputer scienceBiologyBiotechnology
• Harnessing the potential of machine learning for advancing “Quality by Design” in biomanufacturing
  Ensuring consistent high yields and product quality are key challenges in biomanufacturing. Even minor deviations in critical process parameters (CPPs) such as media and feed compositions can significantly affect product critical quality attributes (CQAs). To …
  openalex Ian Walsh, Matthew Myint, Terry Nguyen‐Khuong, Ying Swan Ho 等 2022-01-09 置信度 0.72 BiomanufacturingQuality by DesignCritical quality attributesBioprocessComputer science
• Fast biofoundries: coping with the challenges of biomanufacturing
  openalex Jonathan Tellechea‐Luzardo, Irene Otero‐Muras, Ángel Goñi‐Moreno, Pablo Carbonell 2022-01-07 置信度 0.72 BiomanufacturingInteroperabilityAutomationComputer scienceProcess (computing)
• Critical challenges and advances in recombinant adeno‐associated virus (rAAV) biomanufacturing
  Gene therapy is a promising therapeutic approach for genetic and acquired diseases nowadays. Among DNA delivery vectors, recombinant adeno-associated virus (rAAV) is one of the most effective and safest vectors used in commercial drugs and clinical trials. How…
  openalex Qiang Fu, Ashli Polanco, Yong Suk Lee, Seongkyu Yoon 2023-05-01 置信度 0.72 BiomanufacturingGenetic enhancementBioprocessAdeno-associated virusContext (archaeology)
• Rapid prototyping of microbial production strains for the biomanufacture of potential materials monomers
  Bio-based production of industrial chemicals using synthetic biology can provide alternative green routes from renewable resources, allowing for cleaner production processes. To efficiently produce chemicals on-demand through microbial strain engineering, biom…
  openalex Christopher Robinson, Pablo Carbonell, Adrian J. Jervis, Cunyu Yan 等 2020-04-23 置信度 0.72 BiomanufacturingBiochemical engineeringSynthetic biologyIndustrial microbiologyMetabolic engineering
• Bioprocess digital twins of mammalian cell culture for advanced biomanufacturing
  openalex Seo‐Young Park, Cheol-Hwan Park, Dong‐Hyuk Choi, Jong Kwang Hong 等 2021-07-03 置信度 0.72 BiomanufacturingBioprocessBiochemical engineeringBioprocess engineeringEngineering
• Engineering unnatural methylotrophic cell factories for methanol-based biomanufacturing: Challenges and opportunities
  openalex Taicheng Zhu, Tongxin Zhao, Olufemi Emmanuel Bankefa, Yin Li 2019-11-04 置信度 0.72 BiomanufacturingMetabolic engineeringBiochemical engineeringSynthetic biologyBiotechnology
• Digital Twins in Biomanufacturing
  openalex Steffen Zobel‐Roos, A. Schmidt, Lukas Uhlenbrock, Reinhard Ditz 等 2020-01-01 置信度 0.72 BiomanufacturingWorkflowProcess (computing)Biochemical engineeringProcess modeling
• Versatile biomanufacturing through stimulus-responsive cell–material feedback
  openalex Zhuojun Dai, Anna J. Lee, Stefan Roberts, Tatyana A. Sysoeva 等 2019-09-16 置信度 0.72 BiomanufacturingSynthetic biologyLysisDownstream processingBacteria
• Metabolism in Human Mesenchymal Stromal Cells: A Missing Link Between hMSC Biomanufacturing and Therapy?
  Human mesenchymal stem cells (hMSCs) are the most commonly-tested adult stem cells in cell therapy. While the initial focus for hMSC clinical applications was to exploit their multi-potentiality for cell replacement therapies, it is now apparent that hMSCs emp…
  openalex Xuegang Yuan, Timothy M. Logan, Teng Ma 2019-05-08 置信度 0.72 BiomanufacturingMesenchymal stem cellCell therapyStromal cellStem cell
• Unlocking the magic in mycelium: Using synthetic biology to optimize filamentous fungi for biomanufacturing and sustainability
  Filamentous fungi drive carbon and nutrient cycling across our global ecosystems, through its interactions with growing and decaying flora and their constituent microbiomes . The remarkable metabolic diversity, secretion ability, and fiber-like mycelial struct…
  openalex Charles Jo, Jing Zhang, Jenny M. Tam, George M. Church 等 2023-01-21 置信度 0.72 BioproductionBiomanufacturingSynthetic biologyBiologyBiotechnology
• Targeted Exosomes for Drug Delivery: Biomanufacturing, Surface Tagging, and Validation
  Exosomes hold great potential to deliver therapeutic reagents for cancer treatment due to its inherent low antigenicity. However, several technical barriers, such as low productivity and ineffective cancer targeting, need to be overcome before wide clinical ap…
  openalex Yingnan Si, Seulhee Kim, Eric Erquan Zhang, Yawen Tang 等 2019-10-09 置信度 0.72 MicrovesiclesExosomeTargeted drug deliveryDrug deliveryCancer research
• Microbial biomanufacturing for space-exploration—what to take and when to make
  As renewed interest in human space-exploration intensifies, a coherent and modernized strategy for mission design and planning has become increasingly crucial. Biotechnology has emerged as a promising approach to increase resilience, flexibility, and efficienc…
  openalex Nils J. H. Averesch, Aaron J. Berliner, Shannon N. Nangle, Spencer Zezulka 等 2023-04-21 置信度 0.72 BiomanufacturingComputer scienceFlexibility (engineering)Systems engineeringRisk analysis (engineering)
• Biomanufacturing in low Earth orbit for regenerative medicine
  Research in low Earth orbit (LEO) has become more accessible. The 2020 Biomanufacturing in Space Symposium reviewed space-based regenerative medicine research and discussed leveraging LEO to advance biomanufacturing for regenerative medicine applications. The …
  openalex Arun Sharma, Rachel A. Clemens, Orquidea Garcia, D. Lansing Taylor 等 2021-12-30 置信度 0.72 BiologyRegenerative medicineAstrobiologyLow earth orbitBiomanufacturing
• Biomanufacturing human tissues via organ building blocks
  openalex Kayla J. Wolf, Jonathan D. Weiss, Sebastien G. M. Uzel, Mark A. Skylar‐Scott 等 2022-05-01 置信度 0.72 BiologyBiomanufacturingComputational biologyCell biologyBiotechnology
• Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study
  Process intensification has shown great potential to increase productivity and reduce costs in biomanufacturing. This case study describes the evolution of a manufacturing process from a conventional processing scheme at 1000-L scale (Process A, n = 5) to inte…
  openalex Jianlin Xu, Xuankuo Xu, Chao Huang, James Angelo 等 2020-01-01 置信度 0.72 BiomanufacturingProductivityComputer scienceEconomicsBiology
• Application and progress of techno-economic analysis and life cycle assessment in biomanufacturing of fuels and chemicals
  To reduce the dependency on petroleum-based products and emission of greenhouse gas, renewable biofuels and chemicals play an important role to meet the unmatched energy demands of the rapidly growing population. However, most biofuel and chemical products do …
  openalex Rongzhan Fu, Lixia Kang, Chenyue Zhang, Qiang Fei 2022-09-26 置信度 0.72 Life-cycle assessmentBiofuelBiomanufacturingSustainabilityGreenhouse gas
• The impact of continuous multicolumn chromatography on biomanufacturing efficiency
  Over the past few years, the capacity bottleneck in biomanufacturing has shifted from the upstream process to the purification process. In particular, capture chromatography steps have become a limiting factor in facility throughput. This is a direct result of…
  openalex Marc Bisschops, Mark Brower 2013-09-30 置信度 0.72 BiomanufacturingBusinessBiotechnologyBiology
• Alternative fat: redefining adipocytes for biomanufacturing cultivated meat
  openalex Shigeki Sugii, Cheryl Yeh Qi Wong, Angela Khin Oo Lwin, Lamony Jian Ming Chew 2022-09-15 置信度 0.72 BiomanufacturingAdipose tissueFood scienceBiologyBiotechnology
• Classification and enzyme kinetics of formate dehydrogenases for biomanufacturing via CO2 utilization
  openalex Christian Førgaard Nielsen, Lene Lange, Anne S. Meyer 2019-06-12 置信度 0.72 Formate dehydrogenaseFormateChemistryEnzymeComputational biology
• Cell-Free Biosystems for Biomanufacturing
  openalex Chun You, Y.-H. Percival Zhang 2012-01-01 置信度 0.72 BiomanufacturingBiochemical engineeringIsobutanolChemistryBiocatalysis
• Virtual Prototyping of Biomanufacturing in Medical Applications
  openalex Yosry Morsi, Cynthia S. Wong, S. S. Patel, Y. S. Morsi 等 2007-11-23 置信度 0.72 BiomanufacturingRapid prototypingComputer scienceVirtual prototypingEngineering
• Microbial Utilization of Next-Generation Feedstocks for the Biomanufacturing of Value-Added Chemicals and Food Ingredients
  Global shift to sustainability has driven the exploration of alternative feedstocks beyond sugars for biomanufacturing. Recently, C1 (CO 2 , CO, methane, formate and methanol) and C2 (acetate and ethanol) substrates are drawing great attention due to their nat…
  openalex Congqiang Zhang, Christoph Ottenheim, Melanie Weingarten, LiangHui Ji 2022-04-11 置信度 0.72 BiomanufacturingMetabolic engineeringBioprocessBiochemical engineeringSynthetic biology
• Bioprocessing 4.0 in biomanufacturing: paving the way for sustainable bioeconomy
  openalex Kamini Pandey, Muskan Pandey, Vinay Kumar, Upasana Aggarwal 等 2023-10-23 置信度 0.72 BioprocessBiomanufacturingBioproductsEngineeringBusiness
• Ubiquitous Chromatin-opening Elements (UCOEs): Applications in biomanufacturing and gene therapy
  Ubiquitous Chromatin-opening Elements (UCOEs) are defined by their ability to consistently confer stable, site of integration-independent transgene expression that is proportional to copy number, including from within regions of heterochromatin such as centrom…
  openalex Jonathan J Neville, Joe Orlando, Kimberly Mann, Bethany McCloskey 等 2017-05-17 置信度 0.72 BiomanufacturingChromatinBiologyPromoterGene
• Biomanufacturing by in vitro biosystems containing complex enzyme mixtures
  openalex Chun You, Y.‐H. Percival Zhang, Y.-H. Percival Zhang 2016-09-25 置信度 0.72 BiomanufacturingBiochemical engineeringFermentationBioprocessSubstrate (aquarium)
• Expanding lysine industry: industrial biomanufacturing of lysine and its derivatives
  L-Lysine is widely used as a nutrition supplement in feed, food, and beverage industries as well as a chemical intermediate. At present, great efforts are made to further decrease the cost of lysine to make it more competitive in the markets. Furthermore, lysi…
  openalex Jie Cheng, Peng Chen, Andong Song, Dan Wang 等 2018-04-13 置信度 0.72 BiomanufacturingLysineCadaverineBiotechnologyChemistry
• Automation and miniaturization: enabling tools for fast, high‐throughput process development in integrated continuous biomanufacturing
  Abstract Process development in the biotech industry leads to investments around hundred of millions of dollars. It is important to mitigate costs without neglecting the quality of process development. Biopharmaceutical process development is important for com…
  openalex Tiago Castanheira Silva, Michel H. M. Eppink, Marcel Ottens 2021-05-06 置信度 0.72 BiomanufacturingProcess developmentAutomationProcess (computing)Engineering
• Biomanufacturing process for the production of bacteriocins from Bacillaceae family
  Abstract Members of Bacillaceae family are of major interest in medical industry due to vast antimicrobial peptides they produce as therapeutic agents. For decades, synthetic and natural occurring antibiotics have been used to treat infectious diseases, but he…
  openalex Ahmad Firdaus B. Lajis 2020-02-19 置信度 0.72 BacteriocinLantibioticsBiomanufacturingBiotechnologyAntimicrobial
• Economic and sustainable revolution to facilitate one-carbon biomanufacturing
  One-carbon (C1) biomanufacturing serves as a substitute for fossil-based feedstocks, aiming to de-fossilize chemical production and foster a circular carbon economy by recycling waste greenhouse gases. Here, we review the key economic and technical barriers as…
  europepmc Chenyue Zhang, Qiang Fei, Rongzhan Fu, Maximilian Lackner 等 2025 置信度 0.80 BiomanufacturingBusinessBiologyBiotechnology
• Toward low-cost biomanufacturing through in vitro synthetic biology: bottom-up design
  While most in vitro synthetic biology projects are usually used for the purposes of basic science research or the formation of high-value products, cell-free synthetic pathway biotransformation (SyPaB), which can implement complicated biochemical reactions by …
  openalex Y.‐H. Percival Zhang, Suwan Myung, Chun You, Zhiguang Zhu 等 2011-01-01 置信度 0.72 BiomanufacturingSynthetic biologyBiocatalysisCofactorBiochemical engineering
• Review article: Commercialization of whole-plant systems for biomanufacturing of protein products: evolution and prospects
  Technology for enabling plants to biomanufacture nonnative proteins in commercially significant quantities has been available for just over 20 years. During that time, the agricultural world has witnessed rapid commercialization and widespread adoption of tran…
  openalex H. Maelor Davies 2010-08-23 置信度 0.72 CommercializationBiomanufacturingBiologyBiotechnologyAgriculture
• Electrochemical separation of organic acids and proteins for food and biomanufacturing
  openalex Nayeong Kim, Jemin Jeon, Raylin Chen, Xiao Su 2021-12-09 置信度 0.72 BiomanufacturingElectrochemistryBiochemical engineeringNanotechnologyChemistry
• The Biomanufacturing of Biotechnology Products
  openalex John D. Conner, Don Wuchterl, Maria Lluna Lopez, Bill Minshall 等 2014-01-01 置信度 0.72 BiomanufacturingBiosimilarBiotechnologyProcess developmentProcess (computing)
• An in vitro synthetic biology platform for emerging industrial biomanufacturing: Bottom-up pathway design
  Although most in vitro (cell-free) synthetic biology projects are usually used for the purposes of fundamental research or the formation of high-value products, in vitro synthetic biology platform, which can implement complicated biochemical reactions by the i…
  openalex Ting Shi, Pingping Han, Chun You, Y.‐H. Percival Zhang 2018-05-30 置信度 0.72 BiomanufacturingSynthetic biologyBiochemical engineeringCommodity chemicalsBiotechnology
• Mechanism‐Guided Design of Highly Efficient Protein Secretion and Lipid Conversion for Biomanufacturing and Biorefining
  Abstract Bacterial protein secretion represents a significant challenge in biotechnology, which is essential for the cost‐effective production of therapeutics, enzymes, and other functional proteins. Here, it is demonstrated that proteomics‐guided engineering …
  openalex Shangxian Xie, Su Sun, Furong Lin, Muzi Li 等 2019-05-01 置信度 0.72 BioproductsBiorefiningBiomanufacturingBiochemistryBiorefinery
• Biomimicry in Bio-Manufacturing: Developments in Melt Electrospinning Writing Technology Towards Hybrid Biomanufacturing
  Melt electrospinning writing has been emerged as a promising technique in the field of tissue engineering, with the capability of fabricating controllable and highly ordered complex three-dimensional geometries from a wide range of polymers. This three-dimensi…
  openalex Ferdows Afghah, Caner Dikyol, Mine Altunbek, Bahattin Koç 2019-08-28 置信度 0.72 BiomanufacturingElectrospinningMaterials scienceNanotechnologyTissue engineering
• Targeted genome editing of plants and plant cells for biomanufacturing
  Plants have provided humans with useful products since antiquity, but in the last 30 years they have also been developed as production platforms for small molecules and recombinant proteins. This initially niche area has blossomed with the growth of the global…
  openalex Johannes F. Buyel, Eva Stöger, Luisa Bortesi 2021-03-01 置信度 0.72 BiomanufacturingGenome editingBiologyBiotechnologyComputational biology
• Categories and biomanufacturing methods of glucosamine
  openalex Qinyuan Ma, Xiuzhen Gao 2019-08-22 置信度 0.72 GlucosamineChitinBiomanufacturingChemistryBiochemistry
• Engineered yeast that make cancer drugs could spare a rare flower.
  pubmed 2026 Aug 4 置信度 0.82
• Engineered microorganisms and nanomaterials in cancer therapy: Emerging hybrid systems and translational challenges.
  The convergence of synthetic biology and nanotechnology has created new opportunities for cancer diagnosis and therapy. Engineered microorganisms exhibit unique tumor-targeting, colonization, and immunomodulatory capabilities, while nanomaterials provide versa…
  pubmed Cheng Y, Yu S, Huang Y, Liu B 2026 Aug 4 置信度 0.82
• Gene-environment interaction between perinatal oxytocin exposure and Pten mutation shapes epigenetic reprogramming of oxytocin signaling and behavior in mice.
  Synthetic oxytocin (Pitocin) is the most commonly used pharmacologic agent for induction and augmentation of labor. Beyond its uterotonic effects, oxytocin plays a critical role in neurodevelopment and social behavior. Dysregulated oxytocin signaling has been …
  pubmed Bussies PL, Tan Z, Shelestak J, Sarn N 等 2026 Aug 4 置信度 0.82
• Identification of the BrSK Gene Family in Flowering Chinese Cabbage and Functional Characterization of BrSK2 Subfamily Involvement in Heat Stress.
  Glycogen synthase kinase 3 (GSK3) kinases are evolutionarily conserved regulators of plant development and stress signaling, yet their contributions to thermotolerance in cool-adapted Brassica crops remain poorly understood. Here, we identified 16 BrSK genes i…
  pubmed Yang H, Chen K, Sharif R, Wang H 等 2026 Aug 4 置信度 0.82
• Adrenergic regulation of the thyroid Axis: β- and α-Adrenergic signals as drivers of hormonal and metabolic homeostasis in lizard Podarcis siculus.
  The adrenergic system is known for its ability to influence various physiological and metabolic processes; however, its involvement in thyroid function in non-mammalian vertebrates remains poorly explored. Adult male lizards were treated with β-adrenergi…
  pubmed Carrella F, Lallo A, Gallicchio V, Boccia S 等 2026 Aug 4 置信度 0.82