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Abstract The front matter for this proceedings is available by clicking on the PDF icon.
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2024-08-20T17:56:17Z
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2023-01-26T17:03:48Z
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Skin thermal burn wounds are classified by depth and require different levels of medical intervention. In this paper, the authors propose a novel treatment method where hyperspectral imaging (HSI) is applied to measure skin burn wound information that guide an…
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Houzhu Ding, Antonio Dole, Filippos Tourlomousis, Robert C. Chang
2016-09-27T13:39:10Z
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2026-03-02T16:20:53Z
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2021-12-24T17:18:31Z
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Nelson Ndahiro, Edward Ma, Tom Bertalan, Marc Donohue 等
2025-07-03T19:48:06Z
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2023-05-09T20:01:41Z
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J. Keasling
2017-05-03T16:08:23Z
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<strong> <strong> A Revolution Beneath the Surface </strong> </strong> In the quiet corners of fermenters and bioreactors, a revolution unfolds. It doesn’t grab headlines like rocket launches or AI breakthroughs, but its implications ma…
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Alexander Titus
2025-01-14T10:38:00Z
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2021-06-28T09:10:21Z
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Josh Speer, David Hinkler, Gareth Alford
2023-08-22T11:20:56Z
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Ruben Carbonell
2024-02-07T08:56:55Z
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Vitamin B 12 (cobalamin), as an essential cobalt-containing vitamin for the human body, boasts significant physiological functions and broad application in the pharmaceutical, animal feed, food, and cosmetic industries. It mainly exists in four forms: adenosyl…
pubmed
Zhang D, Wang H, Kang Q, Dawei Zhang 等
2026
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europepmc
Hao Fang, Anping Zeng
2026
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China has made rapid progress from fundamental research to industrial translation in polyhydroxyalkanoates (PHA) biomanufacturing, with polyhydroxybutyrate (PHB) and its copolymers as representative products. Propelled by the national "dual carbon" strategy, C…
pubmed
Yang W, Yang F, Guo W, Chen GQ 等
2026
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Ascorbic acid (AsA) is a crucial water-soluble antioxidant in plant cells, playing a central role not only in plant growth, development, and stress responses but also serving as an essential nutrient for human health. Since the human body cannot synthesize AsA…
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Lu J, Xue Z, Zhao X, Qi X 等
2026
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Diols represent a crucial class of bulk chemicals with extensive applications across the polymer, cosmetics, fuel, food, and pharmaceutical industries. Developing biological routes to produce diols from renewable feedstocks such as biomass and C1 substrates is…
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Liu Y, Liu K, Tsuboi T, Chen Z
2026
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The translation of microbial biotechnology from laboratory research to commercial application remains a persistent challenge, despite decades of effort. A key yet often neglected issue is the misalignment between microbial host selection, product properties, a…
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Wang S, Li Z, Hu P, Wang Q 等
2026
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Biomanufacturing is transitioning from laboratory innovation to industrial-scale production. However, a conceptual ambiguity persists regarding its industrial nature: is it a cutting-edge biotechnology or an asset-heavy manufacturing industry This ambiguity ha…
pubmed
Guo H
2026
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europepmc
2026
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europepmc
2026
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Biomanufacturing is an emerging manufacturing paradigm that uses biological systems as its core tools and biomass as the main feedstock to achieve material synthesis and processing through biosynthesis and biotransformation. It is an important direction for th…
pubmed
Wang Q, Yang P, Zeng Y, Zhou X 等
2026
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Oxalate decarboxylase (OXDC) holds substantial potential for applications in food safety, feed supplementation, and environmental remediation. Nevertheless, its industrial production is still restricted by antibiotic-dependent plasmid maintenance, refined subs…
pubmed
Hou N, Guo H, Wang T, Li D 等
2026
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While polyhydroxyalkanoate block copolymers offer a sustainable route to advanced biodegradable materials, precise architectural control remains challenging. Here, we report Marinobacterium sediminicola CGMCC 1.7287 as a distinctive host for PHB-b-PHV biosynth…
pubmed
Wang MR, Yi J, Li ZJ
2026
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europepmc
2026
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europepmc
2026
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Abstract Chinese hamster ovary (CHO) cells are the dominant platform for recombinant biotherapeutics, yet the impact of producer cell line selection on mammalian cell metabolism remains poorly understood. Here, we performed 41 independent 13 C-tracer experimen…
europepmc
Venkata Gayatri Dhara, Jacqueline E. Gonzalez, Harnish Mukesh Naik, Brian O. McConnell 等
2026
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Anaerobic gastrointestinal commensals are critical regulators of host health and key chassis resources for sustainable green biomanufacturing. Megasphaera elsdenii is a Gram-negative, strictly anaerobic coccus that widely colonizes the gastrointestinal tract o…
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Li Z, Zhang L, Lin Y, Liu H 等
2026
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Sustainable biomanufacturing seeks to replace fossil-fuel-based production with renewable bioeconomies, with microbial cell factories serving as key platforms for producing fuels, chemicals, and high-value products. This review highlights recent advances that …
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Ogawa Y, Shirai T, Yuki Ogawa, Tomokazu Shirai
2026
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Acute infections caused by multidrug-resistant (MDR) Klebsiella pneumoniae immediately necessitate the development of novel therapeutic strategies. Phage therapy offers a viable alternative for combating MDR Klebsiella infections. Here, we report the isolation…
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Ahmad R, Zakirullah, Shafqat A, Li M 等
2026
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The lack of research on the tolerance mechanism of Acetobacter to citric acid has limited the efficient production of acetic acid in high citric acid environments, such as lemons and their processed by-products. In this study, comparative resequencing and tran…
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Yang S, Li K, Guo Y, Wu D 等
2026
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Abstract The increasing availability of genomic and metagenomic data has created significant opportunities to explore microbial diversity, biosynthetic potential and functional traits. However, comprehensive and comparative genome analysis often requires integ…
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Ardhendu Chakrabortty, Lovepreet Singh, Babanpreet Kaur, Sunaina Paliyal 等
2026
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Triterpenoids are important natural secondary metabolites with diverse bioactivities, including antioxidant, anti-inflammatory, and anti-cancer properties, making them valuable for applications in the pharmaceutical, cosmetic, and food industries. Currently, t…
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Jiao N, Shan Z, Chen X, Ning Jiao 等
2026
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Computational design has emerged as an important approach for the discovery of peptide ligands in development of affinity chromatography. However, fast and efficient identification of high-affinity and specific ligands is still challenging. Here an artificial …
pubmed
Zhao Y, Wang F, Dong X, Jia G 等
2026
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The integration of Process Analytical Technologies (PAT) within digital twin architecture represents an important advancement in biopharmaceutical manufacturing. While existing literature has separately addressed digital twin dimensions, interoperability level…
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Satwekar A, Gracieux-Singleton MC, Cummings C, Horton JAR 等
2026
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Two-stage bioprocesses which decouple cell growth from product synthesis are an attractive approach to biomanufacturing. However high levels of production in stationary phase cultures often suffer from a progressive decline in metabolism. We demonstrate that i…
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Yano U, Sarkar P, Lynch MD, Utsuki Yano 等
2026
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Diterpenoids are natural compounds composed of four isoprene units. They possess diverse biological activities and widespread applications in the cosmetics, food additives and pharmaceutical. With the rapid advancement of synthetic biology, the biomanufacturin…
pubmed
Han Y, Luo Y, Wang K, Lin L 等
2026
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This issue features a perspectives article grounded in 10 000-ton scale industrial practice, proposing the "neo-chemical industry" as a new lens for understanding biomanufacturing. This commentary discusses why this perspective deserves attention, what new und…
pubmed
Li Y
2026
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europepmc
2026
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Bioreactors are known for their ability to provide a controlled environment for the cultivation of various biological systems. While microbial systems are primarily known for their speed and cost advantages in industrial enzyme and simple protein production, m…
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Karataş RB, Ayaz F, Aydemir E, Rumeysa Berra Karataş 等
2026
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europepmc
2026
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Most conventional alkene synthesis reactions (e.g., elimination et al.) inherently favor the formation of thermodynamically more stable E-isomers, posing a long-standing challenge for direct access to Z-alkenes. Here, we report the reprogramming of a thiamine …
pubmed
Li H, Yang T, Zhao Y, Pan R 等
2026
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europepmc
2026
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europepmc
2026
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europepmc
2026
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Natural biological CO 2 fixation converts atmospheric CO 2 to energy-dense carbohydrates, thereby providing an alternative to fossil fuels and contributing to the restoration of carbon balance. Recent advancements in the mechanisms of biological CO 2 fixation …
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Zhao C, Zhu P, Chai T, Zhang J 等
2026
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europepmc
2026
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europepmc
2026
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Eggplant fruits exhibit remarkable natural variation in both the intensity and spatial distribution of anthocyanin pigmentation, yet the genetic bases underlying the dominant anthocyaninless fruit (ALF) phenotype in many white- and green-fruited accessions rem…
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Li Y, Tian Y, Li W, Zhao X 等
2026
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europepmc
2026
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europepmc
2026
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europepmc
2026
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Facing the protein supply-demand contradiction brought about by global population growth and the resource and environmental constraints of traditional agricultural production models, developing efficient and sustainable new protein sources has become a major s…
pubmed
Zhang M, Xue X, Wang M, Zhang N 等
2026
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COVID-19, caused by a novel virus, SARS-CoV-2, has now become international endemic. It posed a challenge to the global biomanufacturing industry for rapid diagnostics, effective therapeutics, and scalable vaccine manufacturing. The biomanufacturing industry p…
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Ishfaq Ahmed, Quendrix Martinez, Shayne McRae, Ashwin Dharmalingam
2026
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In recent decades, the evolution of optogenetic engineering has revolutionised biomedical (neuroscience) research and synthetic biology. It also opens exciting opportunities in the biomanufacturing sector, paving the way for opto-biotechnology, a light-driven …
europepmc
Rajani Singh, Shilpa Mohanty, Suneel Kateriya
2026
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europepmc
Ji Yeon Kim, Hye Eun Yu, Min Ho Kim, Sang Yup Lee
2026
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europepmc
2026
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europepmc
2026
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Industrial fermentation is central to the sustainable production of fuels and chemicals, yet commercial viability of emerging technologies hinges on improving fermentation titer, rate, and yield (TRY). How these metrics shape system cost remains difficult to g…
pubmed
Bhagwat SS, Rao CV, Zhao H, Singh V 等
2026
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europepmc
Wen Lv, Yunhao Li, Shijie Wang, Menghao Cai
2026
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Rhamnolipid manufacturing is transitioning from empirical cultivation to programmable, multi-scale molecular bioengineering. This review highlights the transition toward safe, non-pathogenic cell factories via genetic stabilization and precursor expansion. We …
pubmed
Cai X, Zhao XR, Xiong L, Xie DX 等
2026
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europepmc
2026
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Clinical practice of digital removable partial denture (RPD) has undergone two profound transformations, shifting from partial digital substitution to full-process digital intelligent empowerment. In the first transformation, the application of digital technol…
pubmed
Zhang N, Dong B, Luo T, Zhao YW 等
2026
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Microbial coculture can integrate advantages and overcome the metabolic imbalance of individual species. Programming strain interactions represents a common routine for synthetic microbial communities with distinct species, which causes difficulties and redund…
pubmed
Xu M, Yu J, Chen X, Li X 等
2026
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With the rapid development of the mRNA pharmaceutical industry, Oligo(dT) chromatography, as a core step in mRNA separation and purification, has garnered increasing attention from both the industry and researchers. This article begins with the fundamental pri…
pubmed
Tian X, Jin J, Zhu X, Wang Y 等
2026
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europepmc
2026
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europepmc
2026
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Bioactive wheat peptides are promising functional ingredients, yet their industrial production remains constrained by low yields, product heterogeneity, and poor scalability associated with conventional enzymatic hydrolysis and chemical synthesis. Here, we rep…
pubmed
Li Y, Zhang Y, Wei J, Zhou Q 等
2026
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Cell-free protein synthesis (CFPS) has the potential to reduce the cost of biologics manufacturing through simplified lysates, high-throughput workflows, and streamlined downstream purification; however, high reagent costs and inconsistent product yields remai…
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Kritharis A, Dhingra A, Tamer M, Yadav VG
2026
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Enantioselective recognition is vital for numerous chemical and biological applications, which, however, remains challenging due to the nearly indistinguishable physicochemical properties of enantiomers. In this study, we report a luminescent sensing strategy …
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Han Z, Wang KY, Huo J, Rushlow J 等
2026
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europepmc
Yashdeep Mukheja, Roshan Lal, Neha Soni, Jasleen Kaur 等
2026
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Oral potentially malignant disorder (OPMD) remains a critical clinical challenge for cancer interception. However, the progression of OPMD toward oral squamous cell carcinoma (OSCC) is driven by profound cellular heterogeneity and dynamic microenvironmental re…
pubmed
Cai X, Cui Y, Ding C, Liu Y 等
2026
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europepmc
2026
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Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by pathological aggregation of α-synuclein and selective loss of dopaminergic neurons. The molecular mechanisms involving microRNA regulation of protein homeostasis remain…
pubmed
Wang G, Huang C, Luo X, Pan J 等
2026
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The advantages of using phages as an alternative to antibiotics are evident in the response to the growing multidrug resistance of microorganisms. Green and efficient extraction methods for phages have attracted considerable attention for large-scale productio…
pubmed
Yang R, Dong Y, Hou H, Yin J 等
2026
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europepmc
Daojun Zhu, Shangyu Li, Lei Zheng, Hongjian Zhang 等
2026
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In herbivorous insects, symbiotic microorganisms provide advantages through digestion, detoxification, and essential nutrient supplementation, thereby influencing the internal physiology of insect hosts. These symbiont-mediated changes can subsequently modulat…
pubmed
Jung M, Kikuchi Y
2026
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europepmc
2026
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Synthetic biology is emerging as a key approach in chemical synthesis, whose efficiency hinges crucially on the direct engineering of metabolic pathways. In this study, we propose a dual-intervention paradigm to reprogram the industrial fungus Fusarium fujikur…
pubmed
Xiao H, Lu TX, Li MH, Yi YL 等
2026
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europepmc
2026
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europepmc
2026
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europepmc
Simone Bachleitner, Anna M Erian, Diethard Mattanovich, Özge Ata
2026
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Glycosylation is a critical structural modification that shapes the pharmacological properties of bioactive ingredients from Traditional Chinese Medicine (TCM), and UDP-glycosyltransferases (UGTs) are the core rate-limiting biocatalysts mediating this process.…
pubmed
Li B, Yao Q, Li C, Li J 等
2026
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europepmc
2026
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Fucosylated human milk oligosaccharides (FHMOs), a pivotal subclass of human milk oligosaccharides, are essential for neonatal health, performing diverse core physiological functions: prebiotic activity, pathogen adhesion inhibition, immune modulation, intesti…
pubmed
Li M, Yao J, Jia R, Han M 等
2026
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europepmc
Jian Li
2026
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europepmc
2026
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europepmc
2026
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europepmc
2026
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Abiotic stress poses a major constraint on the growth and productivity of climacteric crops worldwide, including banana. Abscisic acid (ABA) is a key phytohormone regulating plant responses to abiotic stresses, and its biosynthesis is therefore critical for st…
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Kumar N, Awasthi P, Tiwari S
2026
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2026
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2026
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europepmc
Qianqian Song, Guohui Zhu, Qihai Liu, Juntai Li 等
2026
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europepmc
2026
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europepmc
2026
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europepmc
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2026
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ABSTRACT The biopharmaceutical industry increasingly relies on single‐use technologies (SUT) for operational flexibility. For a long time, SUT was considered more sustainable than stainless‐steel (SST) systems due to water and energy savings. This study re‐eva…
pubmed
Reiners J, Bruno-Thakur K, Romeo D, Kuśmierczyk W 等
2026
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