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• Engineering Naematelia aurantialba as a Robust Synthetic Biology Chassis: Stable Episomal Vector Construction and Metabolic Optimization for Enhanced Polysaccharide Synthesis.
  Naematelia aurantialba is a promising basidiomycete chassis for bioproduction, yet its development is hindered by a lack of efficient genetic tools. This study established a robust genetic platform for N. aurantialba NX-20. First, protoplast regeneration was o…
  pubmed Ma Y, Wang Y, Zhang M, Sun L 等 2026 Aug 4 置信度 0.82
• Biology-informed reinterpretation of lattice radiotherapy using non-local bystander signalling and anatomy-aware vascular sink modelling.
  Lattice radiotherapy is usually evaluated using physical dose metrics such as target coverage, peak-to-valley dose ratio (PVDR), and organ-at-risk dose, but these metrics do not explicitly represent non-local biological signalling. This study developed a hypot…
  pubmed Woodger K 2026 Aug 4 置信度 0.82
• Dual-site co-valence cycling nanozyme for boosted cuproptosis and triple-modal photo-catalytic-immunotherapy via redox homeostasis imbalance.
  Disrupting redox homeostasis is a feasible strategy for reversing immunosuppressive tumor microenvironment. Herein, by coating copper selenide (Cu 2-x Se) on the surface of gold/molybdenum (AuMo), a AuMo@Cu 2-x Se nanozyme with triple-enzyme activities of gluc…
  pubmed Wang W, Niu Z, He L, Liu Y 等 2026 Aug 3 置信度 0.82
• In Silico discovery and preliminary serological evaluation of an NcSRS2-derived synthetic peptide for the diagnosis of Neospora caninum in dogs and cattle.
  Neospora caninum is an Apicomplexa parasite with a broad host range. It causes neurological disorders in dogs and is a major cause of abortion and stillbirths in cattle, leading to a significant economic impact on livestock production. An effective control of …
  pubmed Motta MLL, Pereira DFS, Moraes JR, Verly RM 等 2026 Aug 3 置信度 0.82
• Evolution after whole-genome duplication (WGD) drives phenotypic and transcriptomic divergence more than WGD in an autopolyploid herb.
  Whole-genome duplication (WGD) is a major driver of plant speciation and often hypothesized to promote rapid adaptation to new or changing environmental conditions. However, the extent to which WGD per se fosters phenotypic and transcriptional novelties, and t…
  pubmed Grünig S, Choudhury RR, Parisod C 2026 Aug 11 置信度 0.82
• Phage as a prospective arsenal against superbugs.
  The escalating crisis of antimicrobial resistance (AMR) necessitates the urgent development of alternatives to traditional antibiotics. Bacteriophage (phage) therapy, which utilizes viruses that specifically infect and lyse bacteria, has re-emerged as a promis…
  pubmed Zhao L, Wan Y, Leung SSY, Yang X 等 2026 Aug 4 置信度 0.82
• SARS-CoV-2 Spike Peptides Trigger Nociceptive Responses Through Spinal TLR4 Pathways.
  Pain is a common neurological manifestation of COVID-19, yet the mechanisms by which SARS-CoV-2 spike protein fragments contribute to nociceptive processing remain poorly understood. We investigated whether spike-derived peptides directly activate spinal neuro…
  pubmed Silva BE, Cardoso RR, Rosário LMR, Prado JP 等 2026 Aug 置信度 0.82
• OxyR regulates the oxidative stress response in Zymomonas mobilis during oxic growth and anoxic biofuel fermentation.
  The bacterium Zymomonas mobilis is widely studied for its potential as an industrial biofuel producer. Anoxic fermentation by Z. mobilis in lignocellulosic hydrolysate can generate bioethanol from renewable plant biomass. In this study, we deleted a gene from …
  pubmed Boismier EC, Felczak MM, Myers KS, TerAvest MA 2026 Aug 4 置信度 0.82
• Trans-dimensional Bayesian model averaging for 13C-metabolic flux analysis: Evidence-based flux inference under structural model uncertainty.
  Accurate quantification of intracellular metabolic fluxes is central to systems biology and biotechnology. Flux estimation relies on biochemical network models, with 13C-metabolic flux analysis (MFA) being the state-of-the-art approach. However, isotope labeli…
  pubmed Jadebeck JF, Stratmann A, Beyß M, Nöh K 2026 Aug 4 置信度 0.82
• DeepGeSeq: Deep learning library for Genomic Sequence modeling and analysis.
  Deep learning methods have demonstrated significant potential in genomics, enabling broad applications such as sequence activity prediction, regulatory rule identification, and variant effect quantification. However, their widespread adoption is often hindered…
  pubmed Li J 2026 Aug 4 置信度 0.82
• BASELINE: a CRISPR base editing platform for mammalian-scale single-cell lineage tracing.
  A cell's fate is shaped by its inherited state, or lineage, and the ever-shifting context of its environment. CRISPR-based recording technologies are a promising solution for mapping the lineage of a developing system; however, challenges remain regarding sing…
  pubmed Winter E, Emiliani F, Cook A, Abderrahim A 等 2026 Jul 17 置信度 0.82
• The plant microbiome: From ecological foundations to precision microbial engineering for sustainable agriculture.
  Plants are best understood as evolutionary holobionts, in which the host and its associated microbiomes operate as an integrated unit to influence growth, health, and stress resilience. This comprehensive review synthesizes the most current knowledge of plant-…
  pubmed Wei M, Lian T, Chen L, Wang L 等 2026 Aug 2 置信度 0.82
• Elastodynamic mechanical analyzer for high strain-rate mechanical characterization.
  Latch-mediated spring actuation (LaMSA) mechanisms are common in nature and hold great promise for ultra-fast synthetic systems across a range of behaviors including jumping, striking, and throwing. However, the quantitative study of LaMSA systems demands simi…
  pubmed Zheng YL, Taghon MM, Freeburn GR, Birnbaum S 等 2026 Aug 4 置信度 0.82
• Machine Learning-Based Prediction of Post-Harvest Losses in Egyptian Strawberry Exports: Cold Chain Analytics, Shelf-Life Estimation, and Export Rejection Risk Modeling.
  Post-harvest losses are the most economically damaging phase of quality deterioration in the Egyptian strawberry export corridor. Egypt is the world's leading exporter of individually quick-frozen strawberries and a top-three supplier of fresh strawberries glo…
  pubmed Elmessery WM, Elwakeel AE, Dessoky ES, Ahmed AF 等 2026 Aug 置信度 0.82
• Phytochemical profiling and insecticidal activity of Moricandia sinaica across growth stages: experimental and molecular docking insights.
  Stored food products are highly vulnerable to infestation by insects and mites, resulting in significant postharvest losses worldwide. Plant-derived bioactive compounds represent promising eco-friendly alternatives to synthetic pesticides. This study investiga…
  pubmed Zatout R, Benslama O, Zatout C, Kacem Chaouche N 等 2026 Aug 3 置信度 0.82
• Bacteriophage P22 Virus-Like Particles as Nanoscale Protein Scaffolds for Plant Synthetic Biology.
  Advancing the utility of plant synthetic biology requires the continued development of protein engineering tools. Self-assembling protein compartments, such as virus-like particles (VLPs), provide versatile scaffolds for synthetic biology. However, few plant-e…
  pubmed Harding MD, Jackson MA, Gilding EK, Craik DJ 等 2026 Aug 3 置信度 0.82
• Author Correction: IDH1-mutant vaccine in newly diagnosed astrocytoma: final analysis of the multicenter, single-arm, open-label, first-in-human phase 1 NOA16 trial.
  pubmed Bunse L, Lindner K, Wick A, Freitag A 等 2026 Aug 3 置信度 0.82
• Computational design of antimicrobial peptide nanopores.
  Antibiotic resistance is a global health threat, driving the need for new molecules that kill bacteria via nontraditional mechanisms. Here, we present a computational de novo design strategy for α-helical peptides that self-assemble into large, stable an…
  pubmed Deb R, Torres MDT, Kabelka I, Přibyl J 等 2026 Aug 3 置信度 0.82
• Breeding for beneficial microbial associations.
  Beneficial plant-microbe associations (BMAs) offer a valuable opportunity to reduce dependence on synthetic inputs. However, traditional breeding has rarely targeted traits that enhance beneficial interactions, and conventional agricultural practices have ofte…
  pubmed Rog I, Lutz S, Fesenfeld L, Hiltbrunner J 等 2026 Aug 3 置信度 0.82
• Mechanism underlying the high regulatory performance of the doxycycline riboswitch G12.
  Synthetic riboswitches provide protein-independent, modular control of gene expression, yet selecting aptamers that reliably couple ligand binding to regulatory switching remains challenging. Here, we identify and mechanistically characterise G12, a doxycyclin…
  pubmed Hoetzel J, Walbrun A, Schäfer M, Wang T 等 2026 Aug 3 置信度 0.82
• Graduate Student Literature Review: Methodologies and tools for synthetic biology for the production of next-generation dairy foods.
  Synthetic biology has played a foundational role in the dairy industry for decades, with continued advancements improving the efficiency, precision, and scalability of producing recombinant dairy foods and additives. As global demand shifts, the industry faces…
  pubmed Madler A, Kennedy K, Morel EF, Brock A 等 2026 Aug 3 置信度 0.82
• Discovery, identification of tricyclic sesquiterpene avermitilol synthase, and its heterologous production in plasmid-free Corynebacterium glutamicum.
  Tricyclic sesquiterpenes are bioactive natural products with broad applications in pharmaceuticals, fragrances, and sustainable aviation biofuels. However, the repertoire of characterized tricyclic sesquiterpene synthases (tSTSs) remains limited. To systematic…
  pubmed Kim SE, Cho YR, Lee HJ, Lee SY 等 2026 Aug 3 置信度 0.82
• Engineering programmable floating wetlands: synthetic biology, sensing, and AI control for water quality.
  Floating treatment wetlands (FTWs) are increasingly used as nature-based water infrastructure, but their performance is often limited by oxygen transfer, hydrodynamic variability, and unstable microbiomes. This review synthesizes bioaugmentation evidence from …
  pubmed Berhanu A, Afzal M, Xian Y, Zhan L 等 2026 Aug 3 置信度 0.82
• A stress-adaptive lipid kinase axis defines metabolic vulnerabilities in neuroendocrine prostate cancer.
  Neuroendocrine prostate cancer (NEPC) persists in a profoundly hypoxic microenvironment, yet the mechanisms enabling tumor adaptation to this metabolically challenging niche remain undefined. Here, we identify the lipid kinase PIKfyve as overexpressed in NEPC,…
  pubmed Zheng Y, Cheng C, Cao Y, Cruz G 等 2026 Aug 3 置信度 0.82
• Protein modification: convergence of artificial intelligence, synthetic biology, and nano-assembly.
  The extensive application of biosynthetically produced proteins in advanced food systems remains limited because of functional deficiencies, including poor solubility, inadequate emulsifying activity, and low in vitro digestibility. To address this gap, this s…
  pubmed Liu P, Wu D, Zhang Z, Li W 等 2026 Jul 31 置信度 0.82
• CIP2A-TOPBP1 complex and PP2A dynamically regulate Polθ recruitment and phosphorylation at mitotic DNA double-strand breaks.
  DNA double-strand breaks (DSBs) that occur during mitosis are primarily repaired by Polθ-mediated microhomology-mediated end joining (MMEJ). The CIP2A-TOPBP1 complex has been shown to tether broken chromatin at mitotic DSBs, but whether it coordinates wi…
  pubmed Zhao X, Chen B, Xu F, Zhang J 等 2026 Aug 11 置信度 0.82
• Transcriptional regulation: Efficient genetic engineering tools for non-conventional yeasts.
  Non-conventional yeasts are recognized as valuable hosts for producing biofuels, pharmaceuticals, and other high-value chemicals, owing to their diverse physiological traits, ability to utilize various substrates, and greater tolerance to environmental stresse…
  pubmed Haneef S, Zhou YJ, Bai F 2026 Aug 3 置信度 0.82
• Oxygen-independent enzymatic dearomatization of homocyclic aromatic compounds.
  Covering: 1995 up to the end of 2025Homocyclic aromatic compounds (HAC) represent the second most abundant class of natural and anthropogenic products. Their biodegradation is central to the global carbon cycle and the bioremediation of aromatic pollutants. A …
  pubmed Zhan T, Breiltgens J, Appel L, Peller L 等 2026 Aug 3 置信度 0.82
• Circular RNAs orchestrate molecular networks in osteoarthritis: From miRNA sponging to epigenetic and exosome-mediated regulation.
  Osteoarthritis (OA) is a progressive degenerative joint disorder characterized by cartilage breakdown, chronic inflammation, and impaired tissue homeostasis, representing a major global health burden with limited disease-modifying therapies. In recent years, c…
  pubmed Yang J, Kubav A 2026 Aug 3 置信度 0.82
• Mitigating chromium-induced oxidative stress in plants: a cross-talk between phytohormones and rhizospheric microbes.
  Hexavalent chromium [Cr(VI)], released from tanning, electroplating, and metallurgical industries, is a Group 1 human carcinogen that induces severe oxidative stress in plants through excessive reactive oxygen species (ROS) production, disrupting antioxidant d…
  pubmed Kaur R, Das PK 2026 Aug 3 置信度 0.82
• Exploring the antihyperglycemic potential of Durio kutejensis (Hassk.) Becc.: in vitro, in vivo, and metabolomic examinations.
  Diabetes mellitus caused 3.4 million deaths in 2024. Although α-glucosidase and DPP-IV inhibitors are utilised therapeutically, synthetic drugs cause side effects. Durio kutejensis was examined for antihyperglycemic potential. This study assessed the ant…
  pubmed Nor I, Rafi M, Garmana AN, Septaningsih DA 等 2026 Aug 3 置信度 0.82
• Can Cells Be Fully Programmed and Engineered?
  Since its inception, synthetic biology has relied on linear genetic modifications to treat living cells as biological counterparts to silicon microchips and computer-aided manufacturing. This paradigm is deeply rooted in the historical frameworks of Turing, Bo…
  pubmed El-Sharoud WM 2026 Aug 2 置信度 0.82
• Bacterial communities on upper and lower leaf surfaces show distinct seasonal response patterns.
  Leaf surfaces represent one of the largest microbial habitats on Earth, which can be divided into upper and lower leaf surfaces. Upper and lower leaf surfaces offer contrasting microenvironments that vary through the seasons. This variation has rarely been qua…
  pubmed Yin X, Ramirez L, Lampei C, Azarbad H 等 2026 Aug 2 置信度 0.82
• Autonomous intranasal delivery systems for central nervous system therapeutics.
  Intranasal delivery provides a rapid, non-invasive route to the central nervous system, bypassing the blood-brain barrier and first-pass metabolism. However, its therapeutic potential remains constrained by the nasal cavity's complex anatomy, the restricted su…
  pubmed Shen H, Srivastava SK, Aggarwal N, Chang MW 2026 Aug 3 置信度 0.82
• [Construction of a long-lived engineered yeast and its efficient catalytic synthesis of ursodeoxycholic acid].
  Ursodeoxycholic acid(UDCA) is a first-line drug for the clinical treatment of hepatobiliary diseases. The bioconversion of chenodeoxycholic acid(CDCA) based on whole-cell catalysis provides an important alternative approach for its green production. However, d…
  pubmed Ma XC, Li ZW, Yang TT, Li WX 等 2026 Jul 置信度 0.82
• Design guide for synthetic small regulatory RNAs for high-efficiency gene knockdown in bacteria.
  Small regulatory RNAs (sRNAs) are short noncoding RNAs that can fine-control the expression of target genes in trans at the post-transcriptional level in prokaryotes. Since there is a big challenge in constructing gene-knockout libraries, synthetic sRNAs have …
  pubmed Ren J, Kim Y, Nam HJ, Lee HM 等 2026 Jul 置信度 0.82
• Terrestrial exposure to microplastics in an endangered salamander (Lyciasalamandraantalyana).
  Microplastics (MPs) are increasingly reported from a wide range of environments, yet information on terrestrial amphibians remains scarce. In this study, we investigated the occurrence and characteristics of MPs in the gastrointestinal tracts of the endemic an…
  pubmed Öztürk D, Akman B, Karış M, Yıldız MZ 等 2026 Aug 2 置信度 0.82
• Evolutionary engineering of synthetic microbial consortia in bioproduction.
  Microbial consortia offer significant advantages over monocultures in biotechnological applications, including access to a broader metabolic repertoire, functional redundancy and the capacity for division of labour. Adaptive laboratory evolution (ALE) has simi…
  pubmed Ruiz-Sanchis D, Ledesma-Amaro R 2026 Aug 2 置信度 0.82
• Antibody Conjugation to Cell Surface Receptors.
  Here, we describe the covalent modification of cell surfaces with antibodies through bioconjugation to the self-labeling SNAP-tag enzyme. We apply this approach to the reprogramming of T cell signaling through the universal chimeric antigen receptor (CAR), "SN…
  pubmed Parikh A, Ruffo E, Deiters A, Lohmueller J 2026 置信度 0.82
• Intelligence Disclosure on Deploying SpyTag/SpyCatcher for Nanoparticle Assembly.
  Immunization with antigens presented multivalently on virus-like particles elicits potent immune responses. The SpyTag/SpyCatcher system, which allows spontaneous covalent bond formation between two proteins, provides a simple route to functionalize virus-like…
  pubmed Hills RA, Howarth MR 2026 置信度 0.82
• Bacterial surface layer ⸻ Properties, role, applications and challenges ⸻ A review of the next-generation nanotechnological tool.
  Surface-layer (S-layer) proteins, forming the outermost envelope of many bacteria and archaea, exhibit extraordinary structural precision and self-assemble into two-dimensional crystalline lattices with square, hexagonal, or oblique symmetry. These monomolecul…
  pubmed Kumar A, Rana A, Kumar A, Tyagi A 2026 Aug 1 置信度 0.82
• Environmental risk assessment for genetically modified microalgae.
  Advances in genomic techniques have great potential to accelerate the development of the microalgal sector and to address key challenges related to upscaling. Genetically modified microalgae (GMM) can exhibit enhanced biomass productivity, increased accumulati…
  pubmed Gallego I, Friedrich A, Robbens J, Romeis J 2026 Jul 31 置信度 0.82
• Cardiomyocyte-specific expression of HIF-1a mediates the cardioprotective effects of Growth Hormone Releasing Hormone (GHRH).
  Heart failure (HF) with preserved ejection fraction (HFpEF) carries a high mortality and remains a major therapeutic challenge. Effective, targeted therapies capable of reversing HFpEF pathophysiology are urgently needed. We previously demonstrated that activa…
  pubmed Kanashiro-Takeuchi RM, Takeuchi LM, Balkan W, Asensi K 等 2026 Aug 1 置信度 0.82
• Valorization of Ficus carica Pruning Residues as Selective Botanical Insecticides: Optimized Furanocoumarin Extraction, Efficacy Against Neotropical Stink Bugs, and Mechanistic Insights via Molecular Docking.
  The Neotropical stink bugs Euschistus heros and Diceraeus melacanthus are major pests of soybean and maize in South America, yet current chemical control strategies face widespread resistance, highlighting the urgent need for sustainable alternatives. This stu…
  pubmed Almeida TA, Páez AR, Costa LTM, Smagghe G 等 2026 Aug 置信度 0.82
• N-terminal fusion length: The key to reliable and context-preserving regulatory sequence characterization.
  Regulatory sequences are commonly characterized using fluorescent reporters, yet how N-terminal coding context shapes these measurements has not been systematically quantified. Here, we evaluated the impact of N-terminal fusion length (45-180 bp) from four gen…
  pubmed Yang S, Liu Y, Li A, Wang S 等 2027 Feb 置信度 0.82
• Mycobacterium tuberculosis PPE2 protein-derived peptide ameliorates DSS-induced colitis by depleting mast cells.
  In the present study, we demonstrated that a synthetic peptide derived from the Mycobacterium tuberculosis PPE2 protein alleviates dextran sodium sulphate (DSS)-induced colitis in mice and markedly improves ulcerative colitis (UC) symptoms, as evidenced by imp…
  pubmed Kushwaha P, Mukhopadhyay S 2026 Aug 21 置信度 0.82
• Seed bacterial microbiota: transmission, community assembly, and prospects for engineering heritable functions in crops.
  Seeds represent specialized, low-biomass microbial niches that facilitate the transmission of the plant-associated microbiota from one generation to another. Residing as both epiphytes and endophytes, seed-associated bacteria contribute to microbial community …
  pubmed Azarbad H, Alizadeh M 2026 置信度 0.82
• Disparities in the access to and use of biologic and targeted synthetic treatments in patients with inflammatory rheumatic and musculoskeletal diseases: a scoping review.
  To identify disparities in the access to and use of biologic and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in inflammatory rheumatic and musculoskeletal diseases (iRMDs).
  pubmed Wright G, Nikiphorou E, Ramiro S, Gossec L 等 2026 Jun 置信度 0.82
• Phylogenomic conflict in Moraceae: Evidence for pervasive introgression and incomplete lineage sorting.
  Although the phylogenetic backbone of Moraceae, an ecologically important angiosperm family in tropical rainforests, has been significantly improved, phylogenetic discordance among nuclear genes and between nuclear and plastid genomes remains common at various…
  pubmed Yang CX, Liu SY, Tian Q, Gu W 等 2026 Jul 置信度 0.82
• Caffeinated Coli: Inspiring the Next Generation of Scientists through Synthetic Biology.
  The Caffeinated Coli Educational Module brings inquiry-driven learning to high schools, introducing students to scientific research, synthetic biology, and genetic engineering. The module focuses on the exploration of a genetically engineered strain of E. coli…
  pubmed Tian NY, Reddy R, Zhang CY, Williams B 等 2026 Jul 21 置信度 0.82
• Locus-Scale Massively Parallel Reporter Assays.
  Interactions among c is -regulatory elements (CREs) are central to mammalian gene regulation. Long @$$ massively parallel reporter assays (LAMPRAs) integrate combinatorial cloning, molecular barcoding and long- and short-read sequencing, to scalably measure ho…
  pubmed McGee AV, Biar CG, Martin BK, Li T 等 2026 Jul 28 置信度 0.82
• Crystal structures of a far-red photoreceptor in different light-absorbing states: insights into spectral tuning and light signaling.
  Cyanobacteriochromes (CBCRs) are bilin-binding photoreceptors with remarkable spectral versatility. Using phycocyanobilin (PCB) as a chromophore, CBCRs regulate diverse light-dependent processes in cyanobacteria, ranging from photosynthesis to chromatic acclim…
  pubmed Biju LM, Ren Z, Kraskov A, Bandara S 等 2026 Jul 22 置信度 0.82
• Host-Informed Engineering of Glycosylation in Komagataella phaffii for Human Biantennary N-Linked Glycans.
  Komagataella phaffii is a common alternative host to mammalian cell lines for heterologous production of recombinant proteins due to its cost-effectiveness and accelerated development. Its native N-linked glycosylation, however, yields high-mannose structures …
  pubmed Yang Y, Naranjo CA, Dalvie NC, Hinckley JA 等 2026 Jul 20 置信度 0.82
• Responsible biotechnology: an analysis of the Asilomar 2025 entreaties.
  Fifty years after the original Asilomar Meeting on Recombinant DNA, new stakeholders in biotechnology reconvened at the Spirit of Asilomar and Future of Biotechnology 2025 Conference. The objective was the responsible advancement of biotechnology, with open-en…
  pubmed Chemla Y, Voigt CA 2026 Jul 31 置信度 0.82
• The biophysical characterization of recombinant glutathione transferase from Plasmodium berghei, a murine model of human malaria: Insights from empirical and computational methods.
  Malaria remains a major global health challenge, exacerbated by the rise of drug-resistant Plasmodium species despite decades of eradication efforts. Glutathione S-transferase (GST), an enzyme that protects parasites from oxidative stress and mediates drug det…
  pubmed Moodley N, Onisuru O, Achilonu I 2026 Jul 31 置信度 0.82
• Gram-scale production of forskolin in yeast through biosynthetic network elucidation and pathway optimization.
  Forskolin, a labdane-type diterpenoid isolated from Coleus forskohlii, exhibits therapeutic potential for osteoporosis, cardiovascular diseases, and metabolic syndrome. Its rising nutraceutical demand and limited natural availability have driven synthetic biol…
  pubmed Jiang M, Tang H, Ma Y, Tian Z 等 2026 Jul 31 置信度 0.82
• Beyond the parasite: reframing cutaneous leishmaniasis as a host-microbiome-vector ecosystem.
  Disease outcomes of cutaneous leishmaniasis (CL) result from dynamic interactions between host immunity, Leishmania parasites and the host-sandfly microbiomes. Current treatments focus on parasite elimination but are limited by toxicity, drug resistance, side …
  pubmed Laetitia Huët MA, Bhaw-Luximon A 2026 Jul 31 置信度 0.82
• Engineering a 660 nm-Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy.
  Inducing tumor cell pyroptosis represents a promising anticancer strategy; however, uncontrolled pyroptosis not only restricts the production of viral delivery vectors but also poses a risk of systemic damage, thereby limiting the translational application of …
  pubmed Zhang M, Li Z, Ma Y, Sun Y 等 2026 Jul 31 置信度 0.82
• From Circuits to Symphonies: A Systems-Engineering Blueprint for Multimicrobial Synthetic Biology.
  Synthetic biology is expanding from single-species engineering toward the design of synthetic microbial consortia capable of distributed metabolism, coordinated behavior, and enhanced functional robustness. However, engineering frameworks derived from intracel…
  pubmed Fernández-Niño M, Wessjohann LA, Guillamón JM, Burgos-Toro D 等 2026 Jul 31 置信度 0.82
• Contextualizing context for synthetic biology – identifying causes of failure of synthetic biological systems
  Despite the efforts that bioengineers have exerted in designing and constructing biological processes that function according to a predetermined set of rules, their operation remains fundamentally circumstantial. The contextual situation in which molecules and…
  openalex Stefano Cardinale, Adam P. Arkin 2012-05-31 置信度 0.72 Synthetic biologyContext (archaeology)Computational biologySystems biologyBiology
• Microbiome Engineering: Synthetic Biology of Plant-Associated Microbiomes in Sustainable Agriculture
  To support an ever-increasing population, modern agriculture faces numerous challenges that pose major threats to global food and energy security. Plant-associated microbes, with their many plant growth-promoting (PGP) traits, have enormous potential in helpin…
  openalex Ke Jing, Bing Wang, Yasuo Yoshikuni 2020-08-13 置信度 0.72 MicrobiomeBiologyComputational biologyAgricultureMetagenomics
• An integrated cell‐free metabolic platform for protein production and synthetic biology
  Cell-free systems offer a unique platform for expanding the capabilities of natural biological systems for useful purposes, i.e. synthetic biology. They reduce complexity, remove structural barriers, and do not require the maintenance of cell viability. Cell-f…
  openalex Michael C. Jewett, Kara Calhoun, Alexei Voloshin, Jessica J. Wuu 等 2008-10-14 置信度 0.72 Synthetic biologyCell-free protein synthesisBiologySystems biologyProtein biosynthesis
• A Synthetic Biology Framework for Programming Eukaryotic Transcription Functions
  openalex Ahmad S. Khalil, Timothy K. Lu, Caleb J. Bashor, Cherie L. Ramirez 等 2012-08-01 置信度 0.72 Synthetic biologyBiologyEukaryotic transcriptionCooperativityComputational biology
• Plant synthetic biology
  openalex Wusheng Liu, C. Neal Stewart 2015-05-01 置信度 0.72 BiologyPlant biologyPlant scienceComputational biologySynthetic biology
• Realizing the potential of synthetic biology
  openalex George M. Church, Michael B. Elowitz, Christina D. Smolke, Christopher A. Voigt 等 2014-03-12 置信度 0.72 Synthetic biologyEngineering ethicsBiologyBioethicsSystems biology
• Synthetic biology strategies for microbial biosynthesis of plant natural products
  Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically challenging to produce and are ubiquitous in medicines, flavors, and fragrances.…
  openalex Aaron Cravens, James T. Payne, Christina D. Smolke 2019-05-13 置信度 0.72 Synthetic biologyMetabolic engineeringBiochemical engineeringHost (biology)Metabolic pathway
• Synthetic Biology: An Emerging Engineering Discipline
  Over the past decade, synthetic biology has emerged as an engineering discipline for biological systems. Compared with other substrates, biology poses a unique set of engineering challenges resulting from an incomplete understanding of natural biological syste…
  openalex Allen A. Cheng, Timothy K. Lu 2012-06-22 置信度 0.72 Synthetic biologySystems biologyBiological engineeringBiological systems engineeringComputer science
• Gene Designer: a synthetic biology tool for constructing artificial DNA segments
  BACKGROUND: Direct synthesis of genes is rapidly becoming the most efficient way to make functional genetic constructs and enables applications such as codon optimization, RNAi resistant genes and protein engineering. Here we introduce a software tool that dra…
  openalex Alan Villalobos, Jon E. Ness, Claes Gustafsson, Jeremy Minshull 等 2006-06-06 置信度 0.72 Synthetic biologyComputer scienceComputational biologyReading frameBiology
• A CRISPR–dCas Toolbox for Genetic Engineering and Synthetic Biology
  Programmable control of gene expression is essential to understanding gene function, engineering cellular behaviors, and developing therapeutics. Beyond the gene editing applications enabled by the nuclease CRISPR-Cas9 and CRISPR-Cas12a, the invention of the n…
  openalex Xiaoshu Xu, Lei S. Qi 2018-06-26 置信度 0.72 CRISPRGenome editingSynthetic biologyToolboxCas9
• Synthetic Biology—The Synthesis of Biology
  Synthetic biology concerns the engineering of man-made living biomachines from standardized components that can perform predefined functions in a (self-)controlled manner. Different research strategies and interdisciplinary efforts are pursued to implement eng…
  openalex Simon Ausländer, David M. Auslander, Martin Fussenegger 2016-12-12 置信度 0.72 Synthetic biologyLiving systemsBiomedicineArtificial cellComputer science
• DNA assembly for synthetic biology: from parts to pathways and beyond
  The assembly of DNA from small fragments into large constructs has seen significant recent development, becoming a pivotal technology in the ability to implement the vision of synthetic biology. As the cost of whole gene synthesis is decreasing, whole genome s…
  openalex Tom Ellis, Tom Adie, Geoff Baldwin 2011-01-19 置信度 0.72 Library scienceClassicsArt historyHistoryComputer science
• Engineering modular and orthogonal genetic logic gates for robust digital-like synthetic biology
  Modular and orthogonal genetic logic gates are essential for building robust biologically based digital devices to customize cell signalling in synthetic biology. Here we constructed an orthogonal AND gate in Escherichia coli using a novel hetero-regulation mo…
  openalex Baojun Wang, R.I. Kitney, Nicolas Joly, Martin Buck 2011-10-18 置信度 0.72 Synthetic biologyModular designNAND gateLogic gateComputer science
• The Emergence of Life: From Chemical Origins to Synthetic Biology
  Preface page xi Acknowledgments xiii List of books on the origin of life xiv 1 Conceptual framework of research on the origin of life on Earth 1 Introduction 1 Determinism and contingency in the origin of life 4 Only one start – or many? 10 The anthropic princ…
  openalex Pier Luigi Luisi 2006-07-17 置信度 0.72 AbiogenesisProtocellAutopoiesisReplication (statistics)Biology
• Genome‐scale engineering for systems and synthetic biology
  Genome-modification technologies enable the rational engineering and perturbation of biological systems. Historically, these methods have been limited to gene insertions or mutations at random or at a few pre-defined locations across the genome. The handful of…
  openalex Kevin M. Esvelt, Harris H. Wang 2013-01-22 置信度 0.72 Genome engineeringBiologySynthetic biologyGenome editingGenome
• A machine learning Automated Recommendation Tool for synthetic biology
  Synthetic biology allows us to bioengineer cells to synthesize novel valuable molecules such as renewable biofuels or anticancer drugs. However, traditional synthetic biology approaches involve ad-hoc engineering practices, which lead to long development times…
  openalex Tijana Radivojević, Zak Costello, Kenneth Workman, Hector Garcia Martin 2020-09-25 置信度 0.72 Synthetic biologyComputer scienceProbabilistic logicMachine learningArtificial intelligence
• Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently
  The amino acid sequence of a protein affects both its structure and its function. Thus, the ability to modify the sequence, and hence the structure and activity, of individual proteins in a systematic way, opens up many opportunities, both scientifically and (…
  openalex Andrew Currin, Neil Swainston, Philip J. Day, Douglas B. Kell 2014-12-15 置信度 0.72 Directed evolutionSequence spaceDirected Molecular EvolutionComputational biologySequence (biology)
• Application of synthetic biology in cyanobacteria and algae
  Cyanobacteria and algae are becoming increasingly attractive cell factories for producing renewable biofuels and chemicals due to their ability to capture solar energy and CO(2) and their relatively simple genetic background for genetic manipulation. Increasin…
  openalex Bo Wang, Jiangxin Wang, Weiwen Zhang, Deirdre R. Meldrum 2012-01-01 置信度 0.72 CyanobacteriaSynthetic biologyAlgaeBiologyBlue green algae
• Overloaded and stressed: whole-cell considerations for bacterial synthetic biology
  openalex Olivier Borkowski, Francesca Ceroni, Guy‐Bart Stan, Tom Ellis 2016-08-03 置信度 0.72 Synthetic biologyBiologyConstruct (python library)ExploitRobustness (evolution)
• Design and characterization of molecular tools for a Synthetic Biology approach towards developing cyanobacterial biotechnology
  Cyanobacteria are suitable for sustainable, solar-powered biotechnological applications. Synthetic biology connects biology with computational design and an engineering perspective, but requires efficient tools and information about the function of biological …
  openalex Hsin-Ho Huang, Daniel Camsund, Peter Lindblad, Thorsten Heidorn 2010-03-17 置信度 0.72 BiologySynthetic biologyCyanobacteriaSynechocystisShuttle vector
• Bottom-Up Synthetic Biology: Engineering in a Tinkerer’s World
  How synthetic can "synthetic biology" be? A literal interpretation of the name of this new life science discipline invokes expectations of the systematic construction of biological systems with cells being built module by module--from the bottom up. But can th…
  openalex Petra Schwille 2011-09-01 置信度 0.72 Synthetic biologyRealmLiteral (mathematical logic)Perspective (graphical)Computer science
• Applications, challenges, and needs for employing synthetic biology beyond the lab
  Synthetic biology holds great promise for addressing global needs. However, most current developments are not immediately translatable to 'outside-the-lab' scenarios that differ from controlled laboratory settings. Challenges include enabling long-term storage…
  openalex Sierra M. Brooks, Hal S. Alper 2021-03-02 置信度 0.72 BioproductionSynthetic biologyComputer scienceFunction (biology)Resource (disambiguation)
• Synthetic biology in mammalian cells: next generation research tools and therapeutics
  openalex Florian Lienert, Jason Lohmueller, Abhishek D. Garg, Pamela A. Silver 2014-01-17 置信度 0.72 Synthetic biologyComputational biologyBiologyContext (archaeology)Systems biology
• Regenesis: how synthetic biology will reinvent nature and ourselves
  Imagine a future in which human beings have become immune to all viruses, in which bacteria can custom-produce everyday items, like a drinking cup, or generate enough electricity to end oil dependency. Building a house would entail no more work than planting a…
  openalex 2013-02-26 置信度 0.72 BiologyEvolutionary biology
• Petri Nets for Systems and Synthetic Biology
  openalex Monika Heiner, David Gilbert, Robin Donaldson 2008-05-30 置信度 0.72 Rotation formalisms in three dimensionsPetri netComputer scienceComplement (music)Stochastic Petri net
• Synthetic biology: understanding biological design from synthetic circuits
  openalex Shankar Mukherji, Alexander van Oudenaarden 2009-11-09 置信度 0.72 Synthetic biologyBiologyGRASPRational designSystems biology
• The second decade of synthetic biology: 2010–2020
  Synthetic biology is among the most hyped research topics this century, and in 2010 it entered its teenage years. But rather than these being a problematic time, we’ve seen synthetic biology blossom and deliver many new technologies and landmark achievements.
  openalex Fankang Meng, Tom Ellis 2020-10-14 置信度 0.72 Synthetic biologyComputational biologyBiologyData scienceComputer science
• Revolutionizing agriculture with synthetic biology
  openalex Eleanore T. Wurtzel, Claudia E. Vickers, Andrew D. Hanson, A. Harvey Millar 等 2019-11-18 置信度 0.72 Synthetic biologyBiologyAgricultureComputational biologyBiotechnology
• The living interface between synthetic biology and biomaterial design
  Recent far-reaching advances in synthetic biology have yielded exciting tools for the creation of new materials. Conversely, advances in the fundamental understanding of soft-condensed matter, polymers and biomaterials offer new avenues to extend the reach of …
  openalex Allen P. Liu, Eric A. Appel, Paul D. Ashby, Brendon M. Baker 等 2022-03-31 置信度 0.72 Synthetic biologyTransformative learningNanotechnologyInterface (matter)Biocompatible material
• Knowledge‐making distinctions in synthetic biology
  Synthetic biology is an increasingly high-profile area of research that can be understood as encompassing three broad approaches towards the synthesis of living systems: DNA-based device construction, genome-driven cell engineering and protocell creation. Each…
  openalex Maureen A. O’Malley, Alexander M. Powell, Jonathan F. Davies, Jane Calvert 2007-12-14 置信度 0.72 Synthetic biologyProtocellContext (archaeology)BiologySystems biology
• Standards for plant synthetic biology: a common syntax for exchange of <scp>DNA</scp> parts
  Inventors in the field of mechanical and electronic engineering can access multitudes of components and, thanks to standardization, parts from different manufacturers can be used in combination with each other. The introduction of BioBrick standards for the as…
  openalex Nicola J. Patron, Diego Orzáez, Sylvestre Marillonnet, Heribert Warzecha 等 2015-07-14 置信度 0.72 Synthetic biologyStandardizationRestriction enzymeCloning (programming)Biology
• Enabling plant synthetic biology through genome engineering
  openalex Nicholas J. Baltes, Daniel F. Voytas 2014-12-12 置信度 0.72 Synthetic biologyGenome engineeringBiologyGenomePlant biology
• Pathway engineering and synthetic biology using acetogens
  Acetogenic anaerobic bacteria are defined as organisms employing the Wood-Ljungdahl pathway to synthesize acetyl-CoA from CO(2) or CO. Their autotrophic mode of metabolism offers the biotechnological chance to combine use of abundantly available substrates wit…
  openalex Bettina Schiel‐Bengelsdorf, Peter Dürre 2012-05-03 置信度 0.72 Biochemical engineeringCommodity chemicalsMetabolic engineeringSynthetic biologyBiofuel
• Preparing synthetic biology for the world
  Synthetic Biology promises low-cost, exponentially scalable products and global health solutions in the form of self-replicating organisms, or "living devices." As these promises are realized, proof-of-concept systems will gradually migrate from tightly regula…
  openalex Gerd Moe-Behrens, Rene Davis, Karmella A. Haynes 2013-01-01 置信度 0.72 BiosafetySynthetic biologyProcess (computing)Genetically engineeredPlan (archaeology)
• Synthetic biology: promises and challenges
  http://dx.doi.org/10.1038/msb4100202
  openalex Luís Serrano 2007-12-18 置信度 0.72 BiologySynthetic biologyComputational biologySystems biology
• Synthetic biology 2020–2030: six commercially-available products that are changing our world
  Synthetic biology will transform how we grow food, what we eat, and where we source materials and medicines. Here I have selected six products that are now on the market, highlighting the underlying technologies and projecting forward to the future that can be…
  openalex Christopher A. Voigt 2020-12-11 置信度 0.72 Synthetic biologyComputer scienceData scienceComputational biologyBiology
• The Next Generation of Synthetic Biology Chassis: Moving Synthetic Biology from the Laboratory to the Field
  Escherichia coli (E. coli) has played a pivotal role in the development of genetics and molecular biology as scientific fields. It is therefore not surprising that synthetic biology (SB) was built upon E. coli and continues to dominate the field. However, scie…
  openalex Bryn L. Adams 2016-09-26 置信度 0.72 Synthetic biologyChassisBiologyField (mathematics)Computer science
• Applications of microbial cytochrome P450 enzymes in biotechnology and synthetic biology
  Cytochrome P450 enzymes (P450s) are a superfamily of monooxygenase enzymes with enormous potential for synthetic biology applications. Across Nature, their substrate range is vast and exceeds that of other enzymes. The range of different chemical transformatio…
  openalex Hazel M. Girvan, Andrew W. Munro 2016-03-22 置信度 0.72 Synthetic biologyCytochrome P450Protein engineeringDirected evolutionEnzyme
• Synthetic biology of modular endolysins
  openalex Hans Gerstmans, Bjorn Criel, Yves Briers 2017-12-15 置信度 0.72 LysinBiologyModularity (biology)Computational biologyAntibiotics
• New Applications of Synthetic Biology Tools for Cyanobacterial Metabolic Engineering
  Cyanobacteria are promising microorganisms for sustainable biotechnologies, yet unlocking their potential requires radical re-engineering and application of cutting-edge synthetic biology techniques. In recent years, the available devices and strategies for mo…
  openalex María Santos‐Merino, Amit Kumar Singh, Daniel C. Ducat 2019-02-27 置信度 0.72 BioproductionSynthetic biologyMetabolic engineeringCyanobacteriaComputational biology
• Programming gene and engineered-cell therapies with synthetic biology
  Gene and engineered-cell therapies promise to treat diseases by genetically modifying cells to carry out therapeutic tasks. Although the field has had some success in treating monogenic disorders and hematological malignancies, current approaches are limited t…
  openalex Tasuku Kitada, Breanna DiAndreth, Brian Teague, Ron Weiss 2018-02-09 置信度 0.72 Synthetic biologyComputational biologyContext (archaeology)Stem cell biologyBiology