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• Identification and application of bioparts for plant synthetic biology.
  europepmc 2025 置信度 0.80
• Advances in synthetic biology for engineering methylotrophic microbial cell factories.
  europepmc 2026 置信度 0.80
• A Bacteroides synthetic biology toolkit to build an in vivo malabsorption biosensor.
  europepmc 2026 置信度 0.80
• Special Milk and Synthetic Biology: A Dual-Perspective Review of Ingredient Substitutions in Breast-Milk-Simulated Infant Formula.
  Breast milk (BM) serves as the gold standard for infant nutrition, yet conventional cow's milk-based infant formulas (IF) fail to adequately replicate its structural and functional complexity. This review critically examines two complementary paradigms, specia…
  pubmed Zhang C, Qiu Y, Mao Q, Wu Y 等 2026 置信度 0.82
• Structure-forward targeting of claudins with synthetic binders.
  Claudins regulate molecular transport between cells via the paracellular route at tight junctions in epithelial and endothelial tissues and are prime targets for biologic therapies. Claudin-claudin interactions through their extracellular segments facilitate f…
  pubmed Vecchio AJ 2026 Aug 6 置信度 0.82
• The halophilic archaeon Halogranum roseipondis sp. nov. is susceptible to a virus carrying an exceptionally high number of viral tRNA genes.
  Archaea constitute a diverse group of organisms, many of which inhabit extreme environments, such as haloarchaea that dominate hypersaline ecosystems, like solar salterns. Sampling of solar salterns and other hypersaline environments has resulted in numerous h…
  pubmed Lampi M, Nordman E, Gregorova P, Ravantti JJ 等 2026 Aug 6 置信度 0.82
• Amylin Coexisting With Peptide YY (PYY) and Amylin/PYY Cells Correspond to Subpopulations of Glucagon- and Glucagon-Like Peptide-1-Immunoreactive Cells in the Japanese Eel (Anguilla japonica) Pancreas.
  The distribution of amylin-like substances was investigated by immunohistochemistry in the pancreas of the Japanese eel (Anguilla japonica). Amylin-immunoreactive cells were observed in pancreatic islets. These immunostaining profiles were not observed by the …
  pubmed Suzuki H, Yamamoto T 2026 Sep 置信度 0.82
• A miniaturized-tumor culture platform for developing anti-tumor immunotherapies.
  The preservation of the tumor immune microenvironment (TIME) ex vivo is essential for investigating tumor-immune interactions and developing effective immunotherapies. However, current culture models often fail to maintain autologous immune cells or support hi…
  pubmed Feng Y, Li L, Lei JH, Peng Y 等 2026 置信度 0.82
• Engineering Biology in an Age of Convergence: Evolving Research Leadership at the AI-SynBio-Robotics Frontier.
  Artificial intelligence (AI), engineering biology (often called synthetic biology), automation, and RNA therapeutics are rapidly converging into integrated discovery and translation platforms in which computational design, automated experimentation, and biolog…
  pubmed McLennan RKJ, Kitney R, Pretorius IS 2026 Jan-Dec 置信度 0.82
• Quantitative MRI Pharmacokinetic Modeling and MALDI Mass Spectrometry Imaging Biodistribution of a pH Mapping MRI Contrast Agent.
  Chemical exchange saturation transfer (CEST) MRI enables noninvasive mapping of tissue pH, a key biomarker of renal physiology and disease. We report a streamlined, three-step synthesis of diGlu, an anionic imidazole-4,5-dicarboxamide bearing two glutamate sub…
  pubmed Mohanta Z, Tressler CM, Gori S, Singh A 等 2026 置信度 0.82
• When less is more: cell size reduction as a metabolic lifeline in Mycoplasma gallisepticum.
  How living cells regulate their function and adapt to stress remains a fundamental question in cell biology. In bacteria, stress responses are classically described at the genomic and transcriptomic levels; however, this paradigm does not adequately explain ad…
  pubmed Matyushkina D, Lazareva A, Vasilyeva E, Polyakova A 等 2026 置信度 0.82
• Modular in-plate synthesis of N-heterocycles for direct-to-biology screening.
  Rapid functional discovery increasingly demands synthetic methods that are compatible with automation, high-throughput experimentation, and minimal operational complexity. Miniaturized parallel synthesis in multi-well microplates provides a compelling alternat…
  pubmed Sun X, Ye Z, Guo F, Chu X 等 2026 Jul 15 置信度 0.82
• Rewired DDR-TGF-β-β-catenin-PD-L1 axis accelerates progression and shapes therapy in human papillomavirus-driven cancer.
  Understanding Human papillomavirus (HPV) oncogenic mechanisms is essential for developing preventive and therapeutic strategies and overcoming therapy resistance in HPV-related cancers. These challenges may arise from the ability of high-risk HPV to subvert ho…
  pubmed Liu W, Chen S, Wang L, Xiang H 等 2026 置信度 0.82
• Cambridge Prisms: Extinction, after 4 years.
  Cambridge Prisms: Extinction was launched to provide an open, synthetic forum for research on the patterns, processes and consequences of extinction. Four years on, the release of the journal's first impact factor offers a useful moment to look back at what ha…
  pubmed Brook BW, Alroy J 2026 置信度 0.82
• A theoretical systems-biology framework for the degradation of mixed plastics and conversion into fertilizer-grade compounds via engineered microbial consortia.
  Plastic pollution is a global environmental challenge of increasing severity. Global plastic production reached approximately 413.8 million metric tonnes in 2023, yet global assessments, including those by Geyer et al., suggest that fewer than 10% of post-cons…
  pubmed Narayanan K 2026 置信度 0.82
• Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications.
  Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have e…
  pubmed Dutta A, Borang N, Yadav M 2026 Aug 6 置信度 0.82
• A decoupled alignment kernel for peptide membrane permeability predictions.
  Cyclic peptides are promising modalities for targeting intracellular sites; however, cell-membrane permeability remains a key bottleneck, exacerbated by limited public data and the need for well-calibrated uncertainty. Instead of relying on data-eager complex …
  pubmed Amirahmadi A, Geylan G, De Maria L, Etminani F 等 2026 Aug 4 置信度 0.82
• Organelle-specific fluorescent probes for live imaging at the nanoscale.
  Intracellular organelles are structures within cells that compartmentalize biochemical reactions for advanced cellular functions. Historically, synthetic dyes that target various cellular targets have been the mainstay for modern cell biology, which are subseq…
  pubmed Liu T, Zhang Z, Chen Z 2026 Aug 3 置信度 0.82
• BRD4 recruitment into HP1 condensates desilences transcription without erasure of repressive chromatin.
  How genes are desilenced without erasure of repressive chromatin is a poorly understood phenomenon. A dominant mode of repression occurs through methylation of lysine 9 of histone H3 (H3K9me3), a mark that engages heterochromatin protein 1 (HP1) to drive chrom…
  pubmed Brandon CJ, Robinson-Thiewes S, Kaulage M, Rosikiewicz W 等 2026 Aug 5 置信度 0.82
• Structure of human cytoplasmic Pol II complex explains global transcription repression by GDOWN1.
  RNA polymerase II (Pol II) is a 12-subunit enzyme crucial for gene transcription in the nucleus. However, its assembly in the cytoplasm, nuclear import, and nuclear function of assembly factors remain poorly understood. Here, we isolated Pol II from the cytopl…
  pubmed Schmitzová J, Zhan Y, Rengachari S, Grabbe F 等 2026 Aug 5 置信度 0.82
• Microbiota, fermentation, and metabolite biotransformation: Pathways to functional foods and personalised nutrition.
  Fermentation is among the oldest biotechnological processes and a modern platform for precision metabolic engineering, enabling the targeted production of health-promoting metabolites. The human gut microbiota, with its complex enzymatic potential, converts di…
  pubmed Mitrea L, Martău GA, Călinoiu LF, Vodnar DC 2026 置信度 0.82
• Cascading Attrition of In Vivo CAR-T Therapy: From Systemic Delivery Failure to Functional Collapse.
  Ex vivo chimeric antigen receptor (CAR)-T cell therapy demonstrates strong efficacy but remains limited by high costs and lengthy manufacturing. In vivo in situ reprogramming provides a scalable "off-the-shelf" alternative by directly engineering endogenous T …
  pubmed Rao H, Xu S, Chen J, Guo Z 2026 Aug 5 置信度 0.82
• Life beyond 6,000 genes: From sequence to synthesis in a post-genomics era.
  The publication of the Saccharomyces cerevisiae genome sequence thirty years ago marked a defining shift in modern biology, establishing yeast as the first fully sequenced eukaryotic model cell. Access to a complete reference genome has catalysed a renaissance…
  pubmed Walker RSK, Archer E, Erpf P, Paulsen IT 等 2026 Aug 5 置信度 0.82
• J. Craig Venter (1946-2026).
  pubmed Moon TS 2026 Aug 置信度 0.82
• Niche exclusion of a lung pathogen in mice with designed probiotic communities.
  For years, the airway microbiota have been theorized to be gatekeepers of respiratory health, as pathogens entering the airway make contact with resident microbes prior to or coincident with their interaction with host cells. Thus, modification of the native a…
  pubmed Hern KE, Phillips AM, Mageeney CM, Williams KP 等 2026 Aug 4 置信度 0.82
• Interactions between fungi, algae, and bacteria: multispecies engineered living materials leverage function and structure.
  The need for materials that have a limited impact on the environment has led to the development of engineered living materials (ELMs), which integrate living organisms and material applications to generate functional matter. Filamentous fungi offer a promising…
  pubmed Kessels Solé M, Wilssens H, Elsacker E, De Wannemaeker L 等 2026 Aug 5 置信度 0.82
• Failed metabolic adaptation to stress contributes to epidermal cell adhesion defects in Darier disease.
  Congenital pathogenic gene variants may not elicit symptoms until later in life, highlighting the importance of identifying extra-genetic factors influencing the onset and severity of heritable diseases. We explored this in Darier disease (DD or ATP2A2 -nEDD),…
  pubmed Harmon RM, McCarthy EF, Krol A, Shetti A 等 2026 Aug 7 置信度 0.82
• Population genomics reveals ginseng domestication and ginsenoside biosynthesis.
  Ginseng ( Panax ginseng ), a valuable medicinal plant, is cultivated for the bioactive ginsenosides with cardiovascular protective effects that are abundant in its roots. However, the genetic basis of its domestication and ginsenoside variation is not fully un…
  pubmed Zhang Y, Wang K, Li Z, Yu X 等 2026 Aug 11 置信度 0.82
• Enhancing the Versatility of Polyethylene Terephthalate (PET) Through Strategic Biomolecular Functionalization.
  As biocatalytic strategies for PET recycling reach maturation, insights gained from PET hydrolase research can be leveraged to inform the design of proteins and surface-functionalization strategies that promote stable association of functional proteins with PE…
  pubmed Eiamthong B, Srimora T, Amornloetwattana R, Uttamapinant C 2026 Aug 5 置信度 0.82
• Manganese Capture-and-Release Vesicles for Cancer Immunotherapy.
  Manganese activates the stimulator of interferon genes (STING) pathway, and its sequestration by the TssS micropeptide of Yersinia pseudotuberculosis is an immune evasion tactic. Inspired by this, we developed MnCARS, Mn CApture-and-Release vesicles with STING…
  pubmed Liu G, Hu F, Ren H, Dong W 等 2026 Aug 5 置信度 0.82
• Computationally Guided Engineering of Multi-Enzyme Cascades Enables Efficient Trehalose Biosynthesis.
  Trehalose is a nonreducing disaccharide widely used for its biomolecule-protective properties. However, multienzyme cascade production remains limited by low enzyme expression and suboptimal catalytic performance. To address this, thermostable maltooligosyltre…
  pubmed Huang H, Li Y, Song J, Zhao Y 等 2026 Aug 5 置信度 0.82
• Experimental and Computational Elucidation of C(sp3)-H Fluorination Barriers in an Iron(II)- and 2-Oxoglutarate-Dependent Halogenase.
  Incorporation of fluorine into pharmaceuticals, agrochemicals, and molecular-imaging agents is of growing importance. Multiple synthetic fluorination methods have recently emerged, and metalloenzymes that are potentially capable of C(sp3)-H fluorination have b…
  pubmed Yadav V, Wang C, Pollock CJ, Ren J 等 2026 Jul 30 置信度 0.82
• Characterization of successive ortho-methyl oxidation of the priority pollutant 2,4-xylenol by a Rieske oxygenase system in Pseudomonas putida NCIMB 9866.
  The catabolism of the priority environmental pollutant 2,4-xylenol requires bacteria to oxidize its ortho -methyl group. Its exact biochemical mechanism is uncharacterized until now. In this study, we resolve key metabolic bottlenecks in Pseudomonas putida NCI…
  pubmed Meng H, Pan S, Chai Z, Zhou L 等 2026 Aug 5 置信度 0.82
• Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis.
  Nutrient limitation is a characteristic feature of poorly perfused tumors. In contrast to well-perfused tissues, nutrient deficits in tumors impose metabolic constraints on cancer cells. The metabolic constraints created by the tumor microenvironment can lead …
  pubmed Jonker PB, Sadullozoda M, Cognet G, Apiz Saab JJ 等 2026 Aug 5 置信度 0.82
• Engineering Organoid Platforms for Pathogenesis Research.
  Emerging and re-emerging infectious diseases ranging from the 1918 H1N1 influenza pandemic to the recent SARS-CoV-2 and monkeypox virus outbreaks continue to pose profound threats to global public health. These crises underscore the critical need for high-fide…
  pubmed Han X, Zhang J, Bai J, Tian W 等 2026 置信度 0.82
• TolC Is Required for a Mixed-Linkage β-Glucan (MLG) Biosynthesis: Engineering Bacteria for MLG Overproduction.
  Mixed-linkage β-glucans (MLGs) are emerging as promising biopolymers with significant biotechnological potential due to their unique structural and rheological properties. In rhizobia, MLG biosynthesis is controlled by the second messenger cyclic di-GMP …
  pubmed Ruiz-Sáez L, Pacheco PJ, Peinado J, Lloret J 等 2026 Aug 置信度 0.82
• Emerging tools to investigate the contribution of selenium to ferroptosis and beyond.
  Selenium has a paradoxical role in biology, being essential at trace levels yet toxic at slightly higher doses. To operate within this narrow range, organisms have developed specialized pathways for selenium uptake, transport and usage/storage, primarily throu…
  pubmed Fazeli G, Ahn I, Pluth MD, de Paiva REF 等 2026 Aug 4 置信度 0.82
• Synthetic biology: applications come of age
  openalex Ahmad S. Khalil, James J. Collins 2010-04-16 置信度 0.72 Synthetic biologyBiologyComputational biologySystems biology
• Synthetic biology
  openalex Steven A. Benner, A. Michael Sismour 2005-07-01 置信度 0.72 Synthetic biologyBiologyNatural (archaeology)Function (biology)Computational biology
• A brief history of synthetic biology
  openalex D. Ewen Cameron, Caleb J. Bashor, James J. Collins 2014-04-01 置信度 0.72 Synthetic biologyTimelineBiologySystems biologyEngineering ethics
• The second wave of synthetic biology: from modules to systems
  openalex Priscilla E. M. Purnick, Ron Weiss 2009-05-22 置信度 0.72 Synthetic biologyConstructiveComputer scienceSystems biologyBiochemical engineering
• Synthetic biology: new engineering rules for an emerging discipline
  openalex Ernesto Andrianantoandro, Subhayu Basu, David Karig, Ron Weiss 2006-05-16 置信度 0.72 Synthetic biologyContext (archaeology)Systems biologyMulticellular organismVariety (cybernetics)
• Engineering microbial consortia: a new frontier in synthetic biology
  openalex Katie Brenner, Lingchong You, Frances H. Arnold 2008-08-01 置信度 0.72 Synthetic biologyBiochemical engineeringBiotechnologyBiologyEngineering
• An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen
  Communication between organelles is an important feature of all eukaryotic cells. To uncover components involved in mitochondria/endoplasmic reticulum (ER) junctions, we screened for mutants that could be complemented by a synthetic protein designed to artific…
  openalex Benoı̂t Kornmann, Erin Currie, Sean R. Collins, Maya Schuldiner 等 2009-06-25 置信度 0.72 Endoplasmic reticulumOrganelleTetheringMitochondrionCell biology
• Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development
  openalex Christopher J. Paddon, Jay D. Keasling 2014-04-01 置信度 0.72 Synthetic biologyArtemisininMetabolic engineeringBiologyBiochemical engineering
• Synthetic Biology Moving into the Clinic
  Synthetic biology is an emerging field focused on engineering biomolecular systems and cellular capabilities for a variety of applications. Substantial progress began a little over a decade ago with the creation of synthetic gene networks inspired by electrica…
  openalex Warren C. Ruder, Ting Lu, James J. Collins 2011-09-01 置信度 0.72 Synthetic biologyVariety (cybernetics)Regenerative medicineSystems biologyBiology
• Synthetic Biology for Synthetic Chemistry
  The richness and versatility of biological systems make them ideally suited to solve some of the world's most significant challenges, such as converting cheap, renewable resources into energy-rich molecules; producing high-quality, inexpensive drugs to fight d…
  openalex Jay D. Keasling 2008-01-01 置信度 0.72 Synthetic biologyBiochemical engineeringMetabolic engineeringCommodity chemicalsNanotechnology
• Synthetic Biology Tools to Engineer Microbial Communities for Biotechnology
  Microbial consortia have been used in biotechnology processes, including fermentation, waste treatment, and agriculture, for millennia. Today, synthetic biologists are increasingly engineering microbial consortia for diverse applications, including the bioprod…
  openalex Nicholas S. McCarty, Rodrigo Ledesma‐Amaro 2018-11-26 置信度 0.72 Synthetic biologyBiotechnologyBiologyBiochemical engineeringComputational biology
• Materials design by synthetic biology
  openalex Tzu‐Chieh Tang, Bolin An, Yuan‐Yuan Huang, Sangita Vasikaran 等 2020-12-23 置信度 0.72 Synthetic biologyLiving systemsNanotechnologyComputer scienceBiomimetics
• Co-culture systems and technologies: taking synthetic biology to the next level
  Co-culture techniques find myriad applications in biology for studying natural or synthetic interactions between cell populations. Such techniques are of great importance in synthetic biology, as multi-species cell consortia and other natural or synthetic ecol…
  openalex Lisa Goers, Paul S. Freemont, Karen M. Polizzi 2014-05-14 置信度 0.72 Synthetic biologySystems biologySet (abstract data type)Natural (archaeology)Biochemical engineering
• Synthetic Biology and Personalized Medicine
  Synthetic biology, application of synthetic chemistry to biology, is a broad term that covers the engineering of biological systems with structures and functions not found in nature to process information, manipulate chemicals, produce energy, maintain cell en…
  openalex Kanika Jain 2012-08-16 置信度 0.72 Synthetic biologyComputational biologyFlexibility (engineering)Systems biologyComputer science
• Exploiting diversity and synthetic biology for the production of algal biofuels
  openalex D. Ryan Georgianna, Stephen P. Mayfield 2012-08-14 置信度 0.72 BiofuelRenewable energyArable landFossil fuelNatural resource economics
• RNA synthetic biology
  openalex Farren J. Isaacs, Daniel J. Dwyer, James J. Collins 2006-05-01 置信度 0.72 Synthetic biologyRNAComputational biologyBiologyNucleic acid
• Synthetic biology to access and expand nature's chemical diversity
  openalex Michael J. Smanski, Hui Zhou, Jan Claesen, Ben Shen 等 2016-02-15 置信度 0.72 Synthetic biologyBiologyComputational biologyGenomeENCODE
• Synthetic biology—putting engineering into biology
  Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we review t…
  openalex Matthias Heinemann, Sven Panke 2006-09-05 置信度 0.72 Synthetic biologySystems biologyDomain (mathematical analysis)Computer scienceHierarchy
• Wearable materials with embedded synthetic biology sensors for biomolecule detection
  Integrating synthetic biology into wearables could expand opportunities for noninvasive monitoring of physiological status, disease states and exposure to pathogens or toxins. However, the operation of synthetic circuits generally requires the presence of livi…
  openalex Peter Q. Nguyen, Luis R. Soenksen, Nina M. Donghia, Nicolaas M. Angenent-Mari 等 2021-06-28 置信度 0.72 Wearable computerCRISPRSynthetic biologyNanotechnologyNucleic acid
• Synthetic DNA Synthesis and Assembly: Putting the Synthetic in Synthetic Biology
  The chemical synthesis of DNA oligonucleotides and their assembly into synthons, genes, circuits, and even entire genomes by gene synthesis methods has become an enabling technology for modern molecular biology and enables the design, build, test, learn, and r…
  openalex Randall A. Hughes, Andrew D. Ellington 2017-01-01 置信度 0.72 Synthetic biologyBiologyOligonucleotideDNA synthesisComputational biology
• Biotechnological domestication of pseudomonads using synthetic biology
  openalex Pablo I. Nikel, Esteban Martínez‐García, Vı́ctor de Lorenzo 2014-04-16 置信度 0.72 Synthetic biologyBiologyBiochemical engineeringComputational biologyDomestication
• Emerging biomedical applications of synthetic biology
  openalex Wilfried Weber, Martin Fussenegger 2011-11-29 置信度 0.72 Synthetic biologySystems biologyInfectious disease (medical specialty)Computational biologyComputer science
• GoldenBraid 2.0: A Comprehensive DNA Assembly Framework for Plant Synthetic Biology
  Plant synthetic biology aims to apply engineering principles to plant genetic design. One strategic requirement of plant synthetic biology is the adoption of common standardized technologies that facilitate the construction of increasingly complex multigene st…
  openalex Alejandro Sarrion‐Perdigones, Marta Vázquez‐Vilar, Jorge Palaci, Bas Castelijns 等 2013-05-13 置信度 0.72 Synthetic biologyModular designComputational biologyIn silicoComputer science
• Engineering living therapeutics with synthetic biology
  openalex Andrés Cubillos-Ruiz, Tingxi Guo, Anna Sokolovska, Paul Miller 等 2021-10-06 置信度 0.72 Synthetic biologyComputational biologyBiologyFlexibility (engineering)Function (biology)
• The Synthetic Biology Open Language (SBOL) provides a community standard for communicating designs in synthetic biology
  openalex Michal Galdzicki, Kevin Clancy, Ernst Oberortner, Matthew Pocock 等 2014-06-01 置信度 0.72 Synthetic biologyWorkflowDocumentationComputer scienceSoftware
• Five hard truths for synthetic biology
  openalex Roberta Kwok 2010-01-01 置信度 0.72 Synthetic biologyField (mathematics)Data scienceBiologyEpistemology
• Cell-free synthetic biology: Thinking outside the cell
  openalex C. Eric Hodgman, Michael C. Jewett 2011-09-18 置信度 0.72 Synthetic biologyBiochemical engineeringCell-free protein synthesisSystems biologyMetabolic engineering
• Synthetic biology devices for in vitro and in vivo diagnostics
  There is a growing need to enhance our capabilities in medical and environmental diagnostics. Synthetic biologists have begun to focus their biomolecular engineering approaches toward this goal, offering promising results that could lead to the development of …
  openalex Shimyn Slomovic, Keith Pardee, James J. Collins 2015-11-23 置信度 0.72 Synthetic biologyComputer scienceNanotechnologyMolecular diagnosticsComputational biology
• Natural strategies for the spatial optimization of metabolism in synthetic biology
  openalex Christina M. Agapakis, Patrick M. Boyle, Pamela A. Silver 2012-05-17 置信度 0.72 Metabolic engineeringSynthetic biologySystems biologyMetabolic networkMetabolic flux analysis
• Adoptive T Cell Transfer for Cancer Immunotherapy in the Era of Synthetic Biology
  openalex Michael Kalos, Carl H. June 2013-07-01 置信度 0.72 Adoptive cell transferAdoptive immunotherapyBiologyImmunotherapyChimeric antigen receptor
• BglBrick vectors and datasheets: A synthetic biology platform for gene expression
  BACKGROUND: As engineered biological systems become more complex, it is increasingly common to express multiple operons from different plasmids and inducible expression systems within a single host cell. Optimizing such systems often requires screening combina…
  openalex Taek Soon Lee, Rachel A. Krupa, Fuzhong Zhang, Meghdad Hajimorad 等 2011-09-20 置信度 0.72 PlasmidComputational biologyBiologyExpression vectorGene
• Cytochrome P450 Monooxygenases in Biotechnology and Synthetic Biology
  openalex Vlada B. Urlacher, Marco Girhard 2019-02-09 置信度 0.72 MonooxygenaseSynthetic biologyBiotechnologyBiologyCytochrome P450
• Control theory meets synthetic biology
  The past several years have witnessed an increased presence of control theoretic concepts in synthetic biology. This review presents an organized summary of how these control design concepts have been applied to tackle a variety of problems faced when building…
  openalex Domitilla Del Vecchio, Aaron J. Dy, Yili Qian 2016-07-01 置信度 0.72 Synthetic biologyComputer scienceRobustness (evolution)Control (management)Field (mathematics)
• Synthetic biology of cyanobacteria: unique challenges and opportunities
  Photosynthetic organisms, and especially cyanobacteria, hold great promise as sources of renewably-produced fuels, bulk and specialty chemicals, and nutritional products. Synthetic biology tools can help unlock cyanobacteria's potential for these functions, bu…
  openalex Bertram M. Berla, Rajib Saha, Cheryl M. Immethun, Costas D. Maranas 等 2013-01-01 置信度 0.72 CyanobacteriaBiologySynthetic biologyComputational biologyEcology
• Synthetic Biology in Cyanobacteria
  openalex Thorsten Heidorn, Daniel Camsund, Hsin-Ho Huang, Pia Lindberg 等 2011-01-01 置信度 0.72 CyanobacteriaSynthetic biologyBiologyContext (archaeology)Photosynthesis
• Synthetic Biology: Integrated Gene Circuits
  A major goal of synthetic biology is to develop a deeper understanding of biological design principles from the bottom up, by building circuits and studying their behavior in cells. Investigators initially sought to design circuits "from scratch" that function…
  openalex Nagarajan Nandagopal, Michael B. Elowitz 2011-09-01 置信度 0.72 Synthetic biologyElectronic circuitNeuronal circuitsComputer scienceBiology
• Needs and Challenges for a Platform to Support Large-scale Requirements Engineering. A Multiple Case Study
  Background: Requirement engineering is often considered a critical activity in system development projects. The increasing complexity of software, as well as number and heterogeneity of stakeholders, motivate the development of methods and tools for improving …
  arxiv Davide Fucci, Cristina Palomares, Dolors Costal, Xavier Franch 等 2018-08-07T09:52:59Z 置信度 0.78 cs.SE
• Linking intra- and extra-cellular metabolic domains via neural-network surrogates for dynamic metabolic control
  We outline a modeling and optimization strategy for investigating dynamic metabolic engineering interventions. Our framework is particularly useful at the early stages of research and development, often constrained by limited knowledge and experimental data. E…
  arxiv Sebastián Espinel-Ríos, José L. Avalos 2023-10-26T06:06:24Z 置信度 0.78 eess.SY
• Research Software Science: Expanding the Impact of Research Software Engineering
  Software plays a central role in scientific discovery. Improving how we develop and use software for research can have both broad and deep impacts on a spectrum of challenges and opportunities society faces today. The emergence of Research Software Engineer (R…
  arxiv Michael A. Heroux 2022-11-16T16:44:23Z 置信度 0.78 cs.SE
• A Course on the Introduction to Quantum Software Engineering: Experience Report
  Quantum computing is increasingly practised through programming, yet most educational offerings emphasize algorithmic or framework-level use rather than software engineering concerns such as testing, abstraction, tooling, and lifecycle management. This paper r…
  arxiv Andriy Miranskyy 2026-02-07T15:35:04Z 置信度 0.78 cs.SEcs.CYcs.ETquant-ph
• The Potential of Citizen Platforms for Requirements Engineering of Large Socio-Technical Software Systems
  Participatory citizen platforms are innovative solutions to digitally better engage citizens in policy-making and deliberative democracy in general. Although these platforms have been used also in an engineering context, thus far, there is no existing work for…
  arxiv Jukka Ruohonen, Kalle Hjerppe 2024-10-04T07:18:26Z 置信度 0.78 cs.SEcs.CY
• AI for Requirements Engineering: Industry adoption and Practitioner perspectives
  The integration of AI for Requirements Engineering (RE) presents significant benefits but also poses real challenges. Although RE is fundamental to software engineering, limited research has examined AI adoption in RE. We surveyed 55 software practitioners to …
  arxiv Lekshmi Murali Rani, Richard Berntsson Svensson, Robert Feldt 2025-11-03T08:15:44Z 置信度 0.78 cs.SEcs.AIcs.HC
• Towards Understanding the Impact of Data Bugs on Deep Learning Models in Software Engineering
  Deep learning (DL) techniques have achieved significant success in various software engineering tasks (e.g., code completion by Copilot). However, DL systems are prone to bugs from many sources, including training data. Existing literature suggests that bugs i…
  arxiv Mehil B Shah, Mohammad Masudur Rahman, Foutse Khomh 2024-11-19T00:28:20Z 置信度 0.78 cs.SE
• Teaching Empirical Research Methods in Software Engineering: An Editorial Introduction
  Empirical Software Engineering has received much attention in recent years and became a de-facto standard for scientific practice in Software Engineering. However, while extensive guidelines are nowadays available for designing, conducting, reporting, and revi…
  arxiv Daniel Mendez, Paris Avgeriou, Marcos Kalinowski, Nauman bin Ali 2025-01-13T10:42:43Z 置信度 0.78 cs.SE
• Stop Words for Processing Software Engineering Documents: Do they Matter?
  Stop words, which are considered non-predictive, are often eliminated in natural language processing tasks. However, the definition of uninformative vocabulary is vague, so most algorithms use general knowledge-based stop lists to remove stop words. There is a…
  arxiv Yaohou Fan, Chetan Arora, Christoph Treude 2023-03-18T15:39:23Z 置信度 0.78 cs.SEcs.CL
• Understanding the Influence of Motivation on Requirements Engineering-related Activities
  Context: Requirements Engineering (RE)-related activities are critical in developing quality software and one of the most human-dependent processes in software engineering (SE). Hence, identifying the impact of diverse human-related aspects on RE is crucial in…
  arxiv Dulaji Hidellaarachchi, John Grundy, Rashina Hoda, Ingo Mueller 2023-04-17T08:40:03Z 置信度 0.78 cs.SE
• Case Survey Studies in Software Engineering Research
  Background: Given the social aspects of Software Engineering (SE), in the last twenty years, researchers from the field started using research methods common in social sciences such as case study, ethnography, and grounded theory. More recently, case survey, a…
  arxiv Jorge Melegati, Xiaofeng Wang 2020-07-27T14:18:59Z 置信度 0.78 cs.SE
• An Exploratory Study on the Engineering of Security Features
  Software security is of utmost importance for most software systems. Developers must systematically select, plan, design, implement, and especially, maintain and evolve security features -- functionalities to mitigate attacks or protect personal data such as c…
  arxiv Kevin Hermann, Sven Peldszus, Jan-Philipp Steghöfer, Thorsten Berger 2025-01-20T15:37:53Z 置信度 0.78 cs.SEcs.CR
• On the Presence of Green and Sustainable Software Engineering in Higher Education Curricula
  Nowadays, software is pervasive in our everyday lives. Its sustainability and environmental impact have become major factors to be considered in the development of software systems. Millennials-the newer generation of university students-are particularly keen …
  arxiv Damiano Torre, Giuseppe Procaccianti, Davide Fucci, Sonja Lutovac 等 2017-03-03T08:39:48Z 置信度 0.78 cs.SEcs.CY
• Does social identity matter in software engineering? Assessing the case of research software engineers
  Social identity is a concept from psychology that refers to the part of an individual's identity that derives from their group membership(s). In this paper, we explore social identity in members of the professional community of Research Software Engineers (RSE…
  arxiv Chukwudi Uwasomba, Tamara Lopez, Melanie Langer, Helen Sharp 等 2026-04-28T16:38:51Z 置信度 0.78 cs.SE
• Software Engineering Challenges of Deep Learning
  Surprisingly promising results have been achieved by deep learning (DL) systems in recent years. Many of these achievements have been reached in academic settings, or by large technology companies with highly skilled research groups and advanced supporting inf…
  arxiv Anders Arpteg, Björn Brinne, Luka Crnkovic-Friis, Jan Bosch 2018-10-29T10:05:37Z 置信度 0.78 cs.SEcs.AIcs.LG
• Human Factors in Software Reliability Engineering
  In this paper, we present our vision of the integration of human factors engineering into the software development process. The aim of this approach is to improve the quality of software and to deal with human errors in a systematic way.
  arxiv Maria Spichkova, Huai Liu, Mohsen Laali, Heinz W. Schmidt 2015-03-12T04:40:08Z 置信度 0.78 cs.SEcs.HC
• ANNOUNCEMENT: Metabolic Engineering, III
  crossref 2002-09-18T14:57:42Z 置信度 0.70
• Emerging hosts for metabolic engineering.
  europepmc Hal S. Alper 2025-10-21T23:40:55Z 置信度 0.80
• Bioinformatics and Metabolic Engineering
  crossref Gregory Stephanopoulos 2002-09-18T18:57:42Z 置信度 0.70
• Substrates for Metabolic Engineering Special Issue
  crossref Hal S. Alper 2022-02-01T21:49:32Z 置信度 0.70
• Metabolic engineering efforts for chemical products special issue
  crossref Hal Alper 2019-08-17T01:47:18Z 置信度 0.70
• Evolutionary metabolic engineering
  crossref Mattheos Koffas, Steve del Cardayre 2005-02-18T12:51:01Z 置信度 0.70
• Flux Estimation Using Isotopic Tracers: Common Ground for Metabolic Physiology and Metabolic Engineering
  crossref Joanne K. Kelleher 2002-09-18T18:57:42Z 置信度 0.70
• Big data and machine learning: Metabolic engineering special issue
  crossref Hal S. Alper 2025-02-20T16:31:01Z 置信度 0.70
• Metabolic engineering: Enabling technology for biofuels production
  crossref Gregory Stephanopoulos 2008-12-06T10:24:58Z 置信度 0.70
• Metabolic engineering of β-lactam production
  crossref Jette Thykaer, Jens Nielsen 2003-05-13T01:38:09Z 置信度 0.70
• Evolution of the Metabolic Engineering Community
  crossref Jens Nielsen, Sang Yup Lee 2018-08-01T03:48:14Z 置信度 0.70