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• Factors associated with death coping ability among geriatric nurses and development of culturally sensitive death education interventions.
  As population aging accelerates, the demand for high-quality end-of-life care for older adults continues to increase. Nurses' death coping ability is essential to the delivery of compassionate end-of-life care and to the maintenance of nurses' psychological we…
  pubmed Liu S, Li Z, Wang Y, Xie W 2026 置信度 0.82
• Taraxerol Alleviates Cerebral Ischemia-Reperfusion Induced Inflammation and Ferroptosis via Regulating AKT/NF-κB Pathway.
  Taraxerol (Tar) is a natural triterpenoid which exhibited anti-inflammatory and neuroprotective properties. Whereas, the roles of Tar in cerebral ischemia-reperfusion injury (CIRI) remain incompletely understood. The research investigated the protective effect…
  pubmed Yang Z, Zhao Z 2026 Aug 31 置信度 0.82
• Aptamer-functionalized aggregation-induced emission micelles for integrated detection and photodegradation of lipopolysaccharides.
  Lipopolysaccharide (LPS) contamination in biopharmaceuticals poses severe clinical risks, yet its detection and removal remain enduring challenges. Conventional detection methods are frequently hindered by low endotoxin recovery. Established clearance techniqu…
  pubmed Wu X, Zhu G, Guo Q, Chen Y 等 2026 Aug 25 置信度 0.82
• Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8(+) T Cells by Inhibiting S100A8/A9-CD36 Axis in Obesity-Associated Pancreatic Adenocarcinoma.
  Pancreatic adenocarcinoma (PAAD), characterized by an immunosuppressive tumor microenvironment (TME) and resistance to immunotherapy, exhibits a dismal prognosis further exacerbated by obesity. This study demonstrates the potent immunomodulatory and antitumor …
  pubmed Chen K, Chen R, Li W, Song B 等 2026 Aug 25 置信度 0.82
• Integrated Multi-Omics Analysis of Gut Microbiota-Associated Metabolites and Related Host Molecular Signatures in Cervical Squamous Cell Carcinoma.
  Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) is a common female malignancy. Gut microbiota and metabolites are critical regulators of tumor immunity and therapy, but their roles in CESC remain unclear. This study integrated TCGA and …
  pubmed Chen B, Xu C 2026 Aug 25 置信度 0.82
• ODC1-associated astrocytic urea cycle dysregulation in age-related memory impairment.
  Aging is an inevitable physiological process characterized by progressive functional decline and degenerative alterations across organ systems. Metabolic disturbance, particularly the disruption of substance and energy metabolism, is increasingly recognized as…
  pubmed Wu M, Zhang S, Zhao X, Zhang B 等 2026 Aug 25 置信度 0.82
• Exosomes in the treatment of age-related ophthalmic diseases: an updated review.
  Exosomes are nanoscale extracellular vesicles of endosomal origin that mediate intercellular communication by transferring bioactive cargo, including proteins, lipids, messenger RNAs, microRNAs, and other regulatory molecules. Through this process, they can mo…
  pubmed Lin L, Zhang J, Xie X 2026 置信度 0.82
• Hesperetin loaded fucoidan selenium nanoparticles alleviate cisplatin induced acute kidney injury via antioxidant and cGAS STING pathway regulation.
  To fabricate hesperetin-loaded fucoidan-selenium (Hes/Fu-Se) nanoparticles (NPs) for alleviating cisplatin-induced acute kidney injury (AKI), overcoming hesperetin's low solubility and bioavailability and boosting antioxidant and anti-inflammatory efficacy.
  pubmed Long L, Zhang Y, Xiao J, Zang J 2026 Aug 25 置信度 0.82
• Integrated genome-wide high-throughput screening and functional validation identifies Sm proteins as essential splicing regulators for gastric cancer progression.
  Alternative splicing mediated by Smith antigen (Sm) proteins involving seven small nuclear ribonucleoprotein polypeptides (SNRPs), plays a critical role in cancer progression. Our previous work identified Sm protein B (SNRPB) as an essential gene in gastric ca…
  pubmed Chen D, Wu J, Zhang Y, Chen Y 等 2026 置信度 0.82
• Bidirectional fermentation of Tremella fuciformis and Acanthopanax trifoliatus alleviates lipid accumulation in LO2 cells.
  Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent metabolic disorder with limited intervention. This study developed a bidirectional fermentation system combining Tremella fuciformis and Acanthopanax trifoliatus (TF-AT) to enhance…
  pubmed Wu Y, Chen S, Chen Y, Yu Q 等 2026 Aug 25 置信度 0.82
• Transient hepatic portal venous gas and gastric emphysema following ingestion of hydrogen peroxide and peroxyacetic acid.
  pubmed Yu G, Lv S, Jian T, Li W 等 2026 Aug 25 置信度 0.82
• Uhrf1-Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease.
  Inflammatory bowel disease (IBD) is characterized by chronic relapsing intestinal inflammation and closely associated with persistent inflammatory responses and impairment of the mucosal barrier integrity. In this work, we demonstrated that Th17/Treg immune im…
  pubmed Zhang J, Xu XR, Zhang HL, Zhu QM 等 2026 Aug 25 置信度 0.82
• Iron-Tannic Acid Hydrogel Mediated Mild Photothermal Therapy Combined With Ferroptosis Enhances Anti-Tumor Immunity in Colorectal Cancer.
  Postoperative recurrence and metastasis are the primary causes of mortality in colorectal cancer (CRC). And its immunosuppressive tumor microenvironment (TME) often results in the poor response to immune checkpoint blockade (ICB). This study designed an inject…
  pubmed Zhu Y, Yu X, Wang T, Liu W 等 2026 Aug 25 置信度 0.82
• Associations of dietary diversity and specific food intake with abnormal sleep duration and sleep quality among older adults in China.
  to examine associations of dietary diversity and specific food intake with abnormal sleep duration (< 6 h or > 8 h) and sleep quality among older adults in China.
  pubmed Luo Y, Qin S, Wang H, Liu L 等 2026 Aug 7 置信度 0.82
• Risk Prediction Models for Unplanned 30-Day Readmission After Discharge of Patients After Undergoing Coronary Revascularization: A Systematic Review and Meta-Analysis.
  Unplanned 30-day readmission is a critical quality indicator in clinical health care. Although the number of risk prediction models related to this research is increasing, uncertainties remain regarding their methodological rigor and clinical practical value.
  pubmed Wang S, Li J, Zhang H, Zhang Q 等 2026 Aug 25 置信度 0.82
• Pulmonary delivery of silk fibroin peptides dry powder inhalers for idiopathic pulmonary fibrosis.
  Idiopathic pulmonary fibrosis (IPF) is a common disease of pulmonary fibrosis with an increasing incidence. Silk fibroin peptides (SFPs) are bioactive substances rich in essential amino acids and possess antioxidant and anti-inflammatory properties; however, t…
  pubmed Ni J, Chen M, Wu Z, Zhang Q 等 2026 Aug 27 置信度 0.82
• Healing effects of Traditional Chinese Medicine plaster Heiyu Gao on refractory diabetic foot ulcers: a case series of ultra-elderly patients with surgical contraindications.
  Debridement surgery and revascularization are essential procedures for treating refractory diabetic foot ulcers (DFUs). However, a significant therapeutic gap exists for patients deemed at prohibitively high surgical risk. We report a case series of three nona…
  pubmed Danyu Z, Chengxiang WU, Yu WU, Jingyu GU 2026 置信度 0.82
• Effect of acupuncture and moxibustion combined with core stabilization training on the function of transverse abdominal muscle and pelvic floor muscle in women with postpartum pelvic pain.
  To evaluate the efficacy of acupuncture and moxibustion combined with core stabilization exercises (CSE) in enhancing the function of the transverse abdominal muscle (TAM) and pelvic floor muscle in postpartum women with pelvic pain.
  pubmed Ling S, Chengcheng Y, Li H, Linwen D 2026 Aug 置信度 0.82
• Altered amino acids and acylcarnitines profile in infantile intrahepatic cholestasis liver disease: implication for Traditional Chinese Medicine syndrome differentiation.
  To explore the diagnostic efficacy of blood amino acids (AAs) and acylcarnitines (ACs) profiles as metabolic biomarkers for differentiating Traditional Chinese Medicine (TCM) syndromes in infantile intrahepatic cholestatic liver disease (IICLD).
  pubmed Yanyan Q, Yu X, Weiwei LI, Suqi Y 等 2026 Aug 置信度 0.82
• Construction of a nomogram for anxiety and depression in patients with Sjögren's syndrome by combining tongue and pulse characteristics: a cross-sectional study based on a prospective cohort.
  To develop and validate a predictive model for predicting psychological complications of Sjögren's syndrome (SS) in combination with tongue and pulse characteristics.
  pubmed Xueyan S, Jiale HE, Zilin G, Fengtao P 等 2026 Aug 置信度 0.82
• Efficacy and safety of Heshu Xiaoji pills combined with standard treatment strategy in hepatitis B virus-related hepatocellular carcinoma: a single-center, open-label, prospective controlled, real-world cohort study.
  To evaluate the effectiveness and safety of Heshu Xiaoji pills (HSXJ, ) as an adjunct to standard treatment in patients with hepatitis B virus-related hepatocellular carcinoma.
  pubmed Xiaoning Z, Yue Y, Yuan K, Mengyun P 等 2026 Aug 置信度 0.82
• Mechanism of Yangxin Dawa Yimixike Mi Gao for myocardial ischemia/reperfusion injury: an integrative study of network pharmacology and and validation.
  To systematically elucidate the cardioprotective mechanisms of the traditional Uyghur polyherbal formulation Yangxin Dawa Yimixike Mi Gao (YXDW, ) against myocardial ischemia/ reperfusion injury through integrated chemical analysis, bioinformatics prediction, …
  pubmed Yuwei D, Qingzhi R, Rahima A, Maiwulanjiang M 等 2026 Aug 置信度 0.82
• Metabolomics and network pharmacology analysis of mechanisms underlying amelioration of tic disorders in rats by Jiawei Huangan Lipi decoction.
  To further investigate the mechanism of Jiawei Huangan Lipi decoction (, JHD) in treating tic disorders (TD) based on metabolomics and network pharmacology.
  pubmed Lijin C, Linghui C, Chengrui W, Yijun F 等 2026 Aug 置信度 0.82
• Antihypertensive effect of acupuncture involve reshaping gut microbiota and alleviating gut inflammation in spontaneously hypertensive rats.
  To investigate the antihypertensive effect and mechanism of acupuncture at Renying (ST9) and Zusanli (ST36) from the perspective of gut microbiota.
  pubmed Jie Z, Zhimin D, Tingyu C, Zhuan L 等 2026 Aug 置信度 0.82
• Jianchang No. 1 (1) formula alleviates irritable bowel syndrome with diarrhea improving gut microbiota and regulating toll-like receptors/nuclear factor-kappa B signaling pathway in bowel syndrome with diarrhea rats.
  To evaluate the therapeutic efficacy of Jianchang No. 1 (1) in treating irritable bowel syndrome with diarrhea (IBS-D) and to explore its underlying mechanisms of action.
  pubmed Yutong L, Yan Y, Huiying XU, Lei LI 等 2026 Aug 置信度 0.82
• Taohong Huazhuo decoction alleviates carbon tetrachloride-induced hepatic fibrosis in rats by inhibiting the nicotinamide adenine dinucleotide phosphate oxidase 4/nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 signaling pathway.
  To explore the mechanism underlying the anti-fibrotic effects of Taohong Huazhuo decoction (THHZD, ).
  pubmed Yuan R, Xiangni C, Lei S, Minghua M 等 2026 Aug 置信度 0.82
• Therapeutic effect of Fuzheng Yixin decoction on cardiac insufficiencythe soluble guanylyl cyclase-cyclic guanosine monophosphate-protein kinase G pathway in a doxorubicin-induced dilated cardiomyopathy rat model.
  To investigate the effect of Fuzheng Yixin decoction (, FZYX) and explore its underlying mechanisms in doxorubicin-induced dilated cardiomyopathy (DCM) rat model.
  pubmed Xiuxiu S, Shuquan L, Feng W, Jing Y 等 2026 Aug 置信度 0.82
• Regulatory effects and mechanisms of the acupuncture-induced complement component 1q on the high mobility group box 1 -receptor for advanced glycation end products-nuclear factor kappa-B pathway at Zusanli (ST36).
  To investigate what are the crucial regulators and mechanisms involved in regulating the inflammatory responses at Zusanli (ST36).
  pubmed Xiaochun K, Sinuo WU, Ningcen LI, Wenyue XU 等 2026 Aug 置信度 0.82
• Yigongsan decoction ameliorates anemia of chronic disease by attenuating mothers against decapentaplegic homolog-signal transducer and activator of transcription 3 interaction to regulate iron homeostasis.
  To investigate how Yigongsan decoction (YGS) regulates iron metabolism in anemia of chronic disease (ACD) by modulating the hepcidin-ferroportin axis, with particular focus on crosstalk between the mothers against decapentaplegic homolog (SMAD) and signal tran…
  pubmed Qin Z, Xiaoqin Z, Jie HU, Jingyang BU 等 2026 Aug 置信度 0.82
• Shaofu Zhuyu decoction can inhibit the progression of endometriosis fibrosis through the transforming growth factor-β1/ smads signaling pathway mediated by 5' adenosine monophosphate-activated protein kinase.
  To investigate the mechanisms by which Shaofu Zhuyu decoction (SFZYD, ) modulates fibrosis in a mouse model of endometriosis.
  pubmed Bingbing LI, Meiqi D, Xiangying C, Wenzhe LI 等 2026 Aug 置信度 0.82
• Paeonol's protective effects on H9C2 cells against hypoxia/ reoxygenation injury through the hypoxia-inducible factor 1-alpha/B-cell lymphoma-2/adenovirus E1B 19 kDa interacting protein 3 signaling pathway.
  To elucidate the cytoprotective capacity of paeonol (PAE) against hypoxia/reoxygenation (H/R) injury in H9C2 cardiomyoblasts and to clarify its regulatory effects on the hypoxia-inducible factor 1-alpha (HIF-1α) and B-cell lymphoma-2/adenovirus E1B 19 kD…
  pubmed Chengguo Z, Meifang Y, Menghan Z, Shuzhi Q 2026 Aug 置信度 0.82
• Cordyceps sinensis and Sonodynamic Therapy in Non-Small Cell Lung Cancer: Pharmacological Basis, Therapeutic Potential, and Future Directions.
  Non-small cell lung cancer (NSCLC) accounts for the highest cancer-related mortality worldwide. Chemotherapy, the backbone of treatment for advanced disease, is constrained by drug resistance and off-target toxicity. Extracts of Cordyceps sinensis (CORS), a me…
  pubmed Zhang Z, Huang C, Ling X, Gan X 等 2026 置信度 0.82
• Shikonin in Hepatocellular Carcinoma: Bridging Metabolic Disruption and Immunomodulation.
  Hepatocellular carcinoma (HCC) is characterized by extensive metabolic changes and an immunosuppressive microenvironment, which interact to promote tumor progression, drug resistance and immune escape. Shikonin, a natural naphthoquinone, exhibits broad antitum…
  pubmed Dong Y, Wang M, Cao Y, Kou X 2026 置信度 0.82
• Prevalence and risk factors of malnutrition in elderly patients with diabetes mellitus: a meta-analysis and systematic review.
  The prevalence and risk factors of malnutrition in elderly patients with diabetes are unclear, a knowledge gap that this meta-analysis aimed to explore.
  pubmed Tang L, Shen Y, Li R, Jia J 等 2026 置信度 0.82
• Effects of cold therapy on ecchymosis and pain after subcutaneous heparin injection: a meta-analysis and systematic review.
  This systematic review and meta-analysis aimed to compare the efficacy of three local physical cooling techniques (ice pack compression, vapor cooling spray, and pre-cooled needles) on pain and ecchymosis after subcutaneous anticoagulant injection, re-examine …
  pubmed Cao XM, Feng XX, Tan YQ, Chen DD 等 2026 置信度 0.82
• Advances in understanding exosome-mediated regulation of macrophage function.
  Exosomes serve as crucial mediators of intercellular communication, regulating cellular functions by carrying proteins, nucleic acids, and lipids. As core components of the immune system, macrophages are closely associated with exosomes. This review focuses on…
  pubmed Qi Y, Li X, Zhou J, Lü C 等 2026 置信度 0.82
• Branched-chain amino acid metabolism and macrophage polarization: potential regulatory nodes and therapeutic targets in diabetes-associated metabolic inflammation.
  T2DM is characterized by chronic low-grade metabolic inflammation, and imbalanced macrophage polarization is a key immunological mechanism contributing to insulin resistance (IR), pancreatic β-cell damage, and diabetes progression. Recent studies in immu…
  pubmed Yang R, Yang R, Zhang H, Yang Y 等 2026 置信度 0.82
• Stretching-Relaxation-Adjustment Manipulation versus Conventional Tuina for Non-Myelopathic Cervical Spondylosis: A Single-Blind Randomized Controlled Trial.
  To systematically evaluate the effectiveness of the innovative massage technique-Stretching-Relaxation-Adjustment Manipulation (SRAM)-as a standalone intervention form for various types of non-myelopathic cervical spondylosis.
  pubmed Zhang Y, Zheng G, Xu Y, Yuan L 等 2026 置信度 0.82
• Effects of Naringenin on Diabetic Nephropathy: A Systematic Review and Meta-Analysis of Rodent Studies.
  Diabetic nephropathy (DN) is a common complication of diabetes. Numerous preclinical studies have yielded inconsistent results in the treatment of DN with NAR. This review aimed to evaluate the effects of NAR on rodent models of DN, providing insights for futu…
  pubmed Qu Y, Chen J, Yue L, Zhang X 等 2026 Aug 置信度 0.82
• RNA-Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities.
  RNA-binding proteins (RBPs) are central regulators of post‑transcriptional gene expression, controlling RNA stability, localization, translation, and alternative splicing. Their functions arise not only from intrinsic RNA-binding domains but also from d…
  pubmed Li L, Yan X, Ji Q, Zhang H 2026 置信度 0.82
• Beyond Drainage: How Lymphatic Vessels Instruct Immune Cell Fate.
  Lymphatic vasculature is increasingly recognized as not only a passive drainage network but also an active regulator of immune cell fate. This regulation operates through two complementary modes. In the direct mode, lymphatic endothelial cells engage immune ce…
  pubmed Guo M, Yang K, Liang Q, Li N 2026 置信度 0.82
• Clinical Research on Integrated Chinese and Western Medicine for Colorectal Cancer with Lung Metastases.
  To evaluate the impact of integrated traditional Chinese and Western medicine (TCM-WM) treatment on survival outcomes in patients with colorectal cancer (CRC) lung metastases.
  pubmed Sun Y, Bian J, Wang L, Zhang T 2026 置信度 0.82
• Precision treatment and frontier advances of glycyrrhizin preparations in drug-induced liver injury (DILI).
  Drug-induced liver injury (DILI) is an important drug-induced disease in clinical practice, with a complex pathogenesis and challenges in diagnosis and treatment. Glycyrrhizin preparations are a class of hepatoprotective agents derived from the traditional Chi…
  pubmed Qiu D, Gao Z, Zhang L, Ma T 等 2026 置信度 0.82
• Multimodal Bioactive Approaches in Smart Dressings for Diabetic Foot Ulcers.
  Diabetes mellitus, a metabolic disorder characterized by chronic inflammation and hyperglycemia, is projected to affect 589 million adults (aged 20-79) globally in 2024, soaring to 853 million by 2050. Diabetic wounds, particularly diabetic foot ulcers (DFUs),…
  pubmed Zhang J, Qin W, Wang X, Yue W 等 2026 置信度 0.82
• The gut-liver axis: microbial mechanisms and therapeutic implications in MAFLD.
  Metabolic dysfunction-associated fatty liver disease (MAFLD) has become the most common chronic liver disease worldwide, currently affecting approximately 32% of the global adult population.Initially presenting as simple hepatic steatosis, MAFLD often progress…
  pubmed Xue L, Wang H, Shan B, Li C 等 2026 置信度 0.82
• Exploring the Therapeutic Potential of Botulinum Toxin in Treating Post-Acne Sequelae: A Critical Review.
  Botulinum toxin has expanded beyond muscle paralysis to multi-target skin regulation, with growing interest in its use for post-acne erythema, atrophic scars, and enlarged pores. However, the quality of evidence varies widely. This article critically integrate…
  pubmed Liao X, Wu J, Cheng H, Zheng H 等 2026 置信度 0.82
• Correlation between frailty status and prolonged length of stay in the post-anesthesia care unit and development of a predictive model in elderly patients undergoing painless gastrointestinal endoscopy.
  The incidence of prolonged length of stay in the post-anesthesia care unit (PACU) is high among elderly patients undergoing painless gastrointestinal endoscopy, and the value of frailty assessment for perioperative risk stratification in this population remain…
  pubmed Chen Z, Zhang J, Zhuang W, Xing F 等 2026 置信度 0.82
• Preclinical pharmacological effects of epimedium-derived interventions in osteoarthritis: a systematic review and meta-analysis.
  The genus Epimedium (Berberidaceae) is widely used in traditional medicine. Recent studies indicate that its botanical metabolites (such as icariin) exhibit anti-inflammatory and chondroprotective potential in osteoarthritis (OA) models. However, a comprehensi…
  pubmed Ji X, Tang R, Wan D, Wu H 等 2026 置信度 0.82
• Vicious cycle: the bidirectional relationship and pathophysiological mechanisms of tinnitus and sleep disturbance.
  In sleep medicine and otology, the comorbidity of tinnitus and sleep disturbance may constitute a debilitating vicious cycle: intrusive phantom auditory perceptions disrupt sleep, whereas poor-quality, nonrestorative sleep further intensifies tinnitus-related …
  pubmed Sun J, Li D, Jin J, Tian Y 等 2026 置信度 0.82
• Letter to the Editor Regarding "Effect of Remimazolam Versus Propofol Sedation on Postoperative Sleep Quality Following Gastroscopy: A Propensity Score-Matched Cohort Study" [Letter].
  pubmed Jin R, Lou Y 2026 置信度 0.82
• CDKN3, PKP2, ADM, MS4A1, FAM83A, and DKK1 Define a Posttranslational Modification (PTM)-Associated Prognostic Model for Lung Adenocarcinoma.
  Posttranslational modification (PTM) plays an important role in protein regulation and may influence tumor initiation and progression. However, the role of PTM-related programs in lung adenocarcinoma (LUAD) remains incompletely understood.
  pubmed Liu Z, Li G, Lin L 2026 置信度 0.82
• Global distribution and genomic characteristics of linezolid resistance gene-positive Enterococcus faecium among humans, animals, and the environment.
  Over the past decade, considerable attention has been directed toward the plasmid-mediated dissemination of linezolid resistance determinants among Enterococcus faecium ( E. faecium ). Despite extensive epidemiological research, a systematic global genomic ana…
  pubmed Zeng J, Wu Y, Li Y, Lv W 等 2026 置信度 0.82
• Case Report: Methemoglobinemia associated with compound aminopyrine-phenacetin tablets supported by toxicological evidence.
  Methemoglobinemia (MetHb) is characterized by the oxidation of ferrous iron (Fe2+) in hemoglobin to the ferric state (Fe3+), resulting in impaired oxygen-carrying capacity and subsequent tissue hypoxia. Acquired methemoglobinemia is most commonly induced by dr…
  pubmed Liu Y, Zhao X, Li W, Shao X 等 2026 置信度 0.82
• Glucolipid metabolic dysfunction in ankylosing spondylitis: inflammatory mechanisms, immune-metabolic crosstalk and therapeutic implications of natural products and traditional Chinese medicine.
  Ankylosing spondylitis (AS) is increasingly recognized as a systemic inflammatory disease accompanied by substantial glucolipid metabolic disturbances and an elevated risk of diabetes. Beyond articular inflammation, persistent immune activation reshapes metabo…
  pubmed Dong X, Zhang J, Chen Z, Liang Y 等 2026 置信度 0.82
• Extensive ocular metastases involving choroid, optic disc, and ciliary body more than 20y after mastectomy: a case report.
  pubmed Wang LP, Wang GP, Lu XJ 2026 置信度 0.82
• Comparative efficacy and safety of Chinese medicine external therapies for diarrhea-predominant irritable bowel syndrome: a systematic review and network meta-analysis.
  Diarrhea-predominant irritable bowel syndrome (IBS-D) is a chronic functional gastrointestinal disorder that significantly impairs patients' quality of life. While various Chinese medicine external therapies (CMETs) have been widely utilized, their relative su…
  pubmed Zhang J, Gao X, Qu Y, Liu J 2026 置信度 0.82
• Environmental exposures in autoimmune inflammatory rheumatic diseases: a priority-based evidence map, immune-mechanism integration audit and research agenda.
  Environmental exposures have been hypothesised to influence immune tolerance, but human studies of autoimmune inflammatory rheumatic diseases (AIRDs) often report exposure-disease associations without measuring immune intermediates. We mapped the structure, di…
  pubmed Zhang C, Pang L, Zhu Z, Wang J 等 2026 置信度 0.82
• Electroacupuncture alleviates osteoarthritis and is associated with changes in gut microbiota and steroid biosynthesis-related metabolites.
  Electroacupuncture (EA) is widely used for osteoarthritis (OA), but its mechanisms remain unclear. This study investigated the therapeutic effects of EA on OA in rats and its potential mechanisms.
  pubmed Ma J, Ouyang L, Zhou X, Peng X 等 2026 置信度 0.82
• Identification of cognitive impairment in patients with hypertension: a systematic review and critical appraisal of existing models.
  Hypertension is strongly associated with cognitive impairment. Existing tools include models designed to identify prevalent cognitive impairment and a smaller number developed to predict future risk. However, their methodological quality, validation status, an…
  pubmed Sun Y, Wang J, Sun F, Shi M 等 2026 置信度 0.82
• Impact of prehospital triggers, time of onset, and symptom-to-door time on the prognosis of patients with coronary heart disease.
  This study aims to conduct a prehospital registry study on coronary heart disease (CHD) to investigate the effects of prehospital triggers, time of onset, and symptom-to-door time (S2D) on the prognosis of patients with CHD, thereby providing evidence to suppo…
  pubmed Tan X, Wang X, Wang M, Wang J 等 2026 置信度 0.82
• Prediction of mortality risk in patients with peripheral artery disease using interpretable machine learning.
  Patients with peripheral artery disease (PAD) face high postoperative mortality risks, necessitating precise risk stratification. While machine learning offers superior performance, its black-box nature limits clinical utility, and the prognostic value of the …
  pubmed Li Y, Zhang Q, Zhao W, Sun Q 等 2026 置信度 0.82
• Association between thyroid feedback quartile index and FIB-4-defined fibrosis risk in patients with metabolic dysfunction-associated steatotic liver disease, type 2 diabetes mellitus, and treated primary hypothyroidism: an exploratory cross-sectional study.
  Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) frequently coexists with Type 2 Diabetes Mellitus (T2DM) and Primary Hypothyroidism (PH); nevertheless, the relationship between thyroid hormone sensitivity and FIB-4-defined fibrosis risk across…
  pubmed Wang Y, Xie J, Wang Y, Liu X 等 2026 置信度 0.82
• Pathophysiological frameworks and emerging preventative strategies in SUDEP.
  Sudden Unexpected Death in Epilepsy (SUDEP) represents a leading cause of epilepsy-related mortality, reflecting a severe disruption of systemic physiology that remains challenging to address using standard clinical protocols. Although generalized tonic-clonic…
  pubmed Xu C, Wang Y, Nie S, Gao J 等 2026 置信度 0.82
• Quantitative study on water and glycosaminoglycan contents based on T(2) relaxation time of intervertebral disks.
  Water and glycosaminoglycan (GAG) are essential for intervertebral disk biomechanics and their loss marks early degeneration, yet the quantitative relationship between T 2 relaxation time and contents of water and GAG remains unclear due to low-resolution samp…
  pubmed Qin B, Jia X, Ni W, Zhou L 等 2026 置信度 0.82
• Effectiveness of a Dyadic Nursing Intervention on Women With Gynaecological Malignancies and Their Family Caregivers: A Randomized Controlled Trial.
  To evaluate the effectiveness of a dyadic illness management-based intervention (Dyadic Guidance and Empowerment Program, D-GEP) in alleviating demoralization among women with gynaecological malignancies and their family caregivers during the hospital-to-home …
  pubmed Ji Y, Zhang C, Che Q, Qu X 等 2026 Aug 25 置信度 0.82
• Two Standards-Aided LC-MS Technologies Uncover 30 "Unreported" Compounds in Natural Bear Bile Powder to Add a New Pharmacopoeia Quality-Marker.
  Natural bear bile powder is a precious traditional Chinese medicine that has a long history of use in clinical practice. The current study analyzed four batches of natural bear bile powder samples (B-1∼B-4) using standards-aided ultra-high-performance l…
  pubmed Li Z, Huang H, Zheng H, Zheng G 等 2026 Aug 置信度 0.82
• Expression of Concern: Protective effects of oxymatrine against DSS-induced acute intestinal inflammation in mice via blocking the RhoA/ROCK signaling pathway.
  pubmed Wang Y, Shou Z, Fan H, Xu M 等 2026 Sep 16 置信度 0.82
• S100A8 Mediating TLR4/NF-κB Axis Activation to Inhibit Diabetic Foot Healing in Bacterial Colonization.
  Diabetic foot ulcers (DFUs) represent a severe complication of diabetes, with persistent nonhealing closely associated with bacterial colonization and excessive inflammation. S100A8 participates in immune regulation, but its mechanism in DFU healing remains un…
  pubmed Wang Q, Sun T, Xu Y, Zhang L 等 2026 Sep 置信度 0.82
• NR1D1-Mediated Suppression of JAK1/STAT3 Signaling Contributes to the Therapeutic Effects of Triptolide in Rheumatoid Arthritis.
  Triptolide demonstrates potent antiarthritic effects in rheumatoid arthritis (RA), although its complete mechanism is not fully elucidated. This study aimed to systematically identify its core targets and regulatory pathways by integrating network pharmacology…
  pubmed Ren C, Li M, He C, Li K 等 2026 置信度 0.82
• Effects of Prism Adaptation on Left and Right Spatial Neglect in Patients with Subacute Stroke: A Multi-Centred Randomized Controlled Trial.
  To investigate the effects of prism adaptation (PA), using a left or right visual shift prism, in terms of improving left spatial neglect (LSN) or right spatial neglect (RSN) in patients after subacute stroke.
  pubmed Feng D, Fong KNK, Zhang H, Chen Y 等 2026 Aug 25 置信度 0.82
• Family Resilience Among Family Members of Intensive Care Unit Patients: A Qualitative Meta-Synthesis.
  ICU critical illness places heavy psychological and financial burdens on families, weakening their coping capacity. Although family resilience helps mitigate these issues, systematic research on experiences and processes of family resilience operating in ICU f…
  pubmed Zhai Z, Wu W, Wei L, Xue H 等 2026 Sep 置信度 0.82
• The roles and mechanisms of natural compounds in preventing and treating viral reproductive disorders in major economic livestock.
  Reproductive disorders from viral infections cause major economic losses in livestock. This review provides a comprehensive mapping of natural compounds (monomers, extracts, and traditional Chinese medicine formulas) against 12 key viruses causing reproductive…
  pubmed Su Q, Wu J, Shi Q, Chen H 等 2026 Aug 24 置信度 0.82
• Oral Colon- and Mitochondria-Targeted Nanoparticles Alleviate Ulcerative Colitis by Reeducating Macrophage Polarization via SIRT3/FOXO3a-Mediated Mitochondrial Restoration.
  Mitochondrial dysfunction in macrophages drives pro-inflammatory M1 polarization in ulcerative colitis (UC). We developed a colon-targeted, mitochondria-directed nanoplatform (KSF@SS31@S100Ns) to restore mitochondrial fitness and alleviate UC.
  pubmed Mei R, Zhang R, Li Z, Luo J 等 2026 Aug 24 置信度 0.82
• ChatGPT-4o for Endoscopic Differentiation of Autoimmune Gastritis From Helicobacter pylori-Associated Atrophic Gastritis: A Post Hoc Head-to-Head Comparison With Specialized Deep Learning.
  pubmed Song Y, Li Z, Zhang X, Fang S 等 2026 Aug 24 置信度 0.82
• Clarifying the Prediction Target of an Ultrasound-Based IHC4-Associated Radiomic Model.
  pubmed Lin X, Huang Y 2026 Aug 24 置信度 0.82
• Arthritis and longitudinal trajectories of depressive symptoms and cognition in middle-aged and older adults: a prospective tri-cohort study.
  The long-term effects of arthritis on psychological well-being and cognitive trajectories across diverse cultural contexts remain inadequately characterized. This study systematically examines the associations between baseline arthritis and the subsequent risk…
  pubmed Chen S, Zhao Y, Huang S, Guo Y 等 2026 Aug 1 置信度 0.82
• Ziyuglycoside I promotes wound healing via GPR34-mediated activation of group 3 innate lymphoid cells.
  Sanguisorba officinalis L., a traditional Chinese medicine, has been frequently utilized to promote the healing of burns and scalds. Ziyuglycoside I (ZG-I), a bioactive compound isolated from the roots of S. officinalis L., exhibits significant properties for …
  pubmed Wang K, Sun Q, Wang G, Zhang J 等 2026 Aug 24 置信度 0.82
• Brain-computer interface for upper limb functional recovery post-stroke: a meta-analysis of improvement in upper limb motor function and changes in neurophysiological markers.
  Brain-Computer Interface (BCI) has emerged as a promising intervention, facilitating recovery of upper limb motor function, enhancing associated neurophysiological markers, and improving activities of daily living (ADL) performance, which is measured using the…
  pubmed Zhang H, Xian R, Zhang Y, Liu X 等 2026 Aug 24 置信度 0.82
• Preperation of an engineered tryptophan-depleted protein in Pichia pastoris and evaluation of its dietary anti-tumor efficacy.
  Targeting amino acid metabolism has emerged as a promising strategy for cancer therapy. To investigate the feasibility of tryptophan restriction as a dietary intervention strategy to suppress tumor growth in vivo , this study developed a novel tryptophan-deple…
  pubmed Dai H, Chen Y, Xie Y, Wang W 等 2026 Aug 25 置信度 0.82
• [Proteomic and metabolomic profiling of the rat model of myocardial ischemia-reperfusion injury treated with electroacupuncture].
  This study aims to explore the protective effect of electroacupuncture (EA) on myocardial ischemia-reperfusion injury (MIRI) and decipher the molecular mechanism. Forty male SD rats were randomly allocated into four groups: sham, model (ischemia/reperfusion, I…
  pubmed Wang H, Li Y, Cao R, Hu Y 等 2026 Aug 25 置信度 0.82
• Berberrubine alleviates PCS-induced tubular injury via HNRNPF/NR4A1/ER stress axis.
  The key uremic toxin p-cresyl sulfate (PCS) has been shown to induce renal tubule injury-mediated chronic kidney disease via endoplasmic reticulum stress (ERS). Berberine offers renoprotective benefits and attenuates ERS-driven apoptosis. Owing to the low oral…
  pubmed Liu Y, Wang YS, Jin SF, Yuan MT 等 2026 Aug 24 置信度 0.82
• Microglial TLR7 contributes to traumatic brain injury-induced neuroinflammation in mice.
  Neuroinflammation driven by activated microglia is an important component of secondary injury after traumatic brain injury (TBI), but the underlying molecular mechanisms remain incompletely understood. Here, we investigated the role of microglial Toll-like rec…
  pubmed Du YT, Ma XL, Gao SH, Wang YX 等 2026 Aug 24 置信度 0.82
• A microenvironment-responsive microsphere-PLGA-PEG-PLGA hydrogel for sustained and coordinated co-delivery of celecoxib and ropivacaine in osteoarthritis therapy.
  In this study, celecoxib (CXB) microspheres (CM) and ropivacaine (RPV) microspheres (RM) were prepared respectively. A poly (D, L-lactide-co-glycolide)-block-poly (ethylene glycol)-block-poly (D, L-lactide-co-glycolide) (PLGA-PEG-PLGA, PPP) was synthesized by …
  pubmed Yuan H, Zhang B, Sun W, Liu H 等 2026 Aug 24 置信度 0.82
• HOXC9 transcriptionally activates NRP1 to promote cell malignant progression and immune evasion in colorectal cancer.
  Transcription factor homeobox C9 (HOXC9) has been reported to be up-regulated and associated with poor prognosis in colorectal cancer (CRC). This study focused on the regulatory role and molecular mechanism of HOXC9 in CRC progression and immune response. Diff…
  pubmed Qiu X, Hu S, Liao B, Zhang H 等 2026 Aug 25 置信度 0.82
• Microbial-Metabolite Signatures Are Associated With Glucocorticoid Responsiveness in Chronic Rhinosinusitis With Nasal Polyps.
  Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) exhibit heterogeneous responses to oral glucocorticoids (GCs), but the biological basis of this variability remains unclear.
  pubmed Zhang YY, Ding XY, Lu MP, Chen YB 等 2026 Aug 24 置信度 0.82
• Merging artificial intelligence and retinal vascular geometric parameters: A novel tool for diagnosis and prognosis prediction of diabetic nephropathy.
  Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. The retinal microvasculature, as the only directly observable microvasculature, may reflect DN progression. This study aims to construct a non-invasive diagnostic and prognostic predict…
  pubmed Pan S, Chen X, Wang Q, Li Z 等 2026 Aug 24 置信度 0.82
• Global Status and Research Trends of Heart Transplantation: A Bibliometrics Analysis.
  In contemporary medical practice, heart transplantation is considered the ultimate recourse for patients suffering from advanced heart failure. Numerous experts have delineated the prevailing challenges and prospective developmental trajectories in the field o…
  pubmed Sun G, Tao S, Xuan F, Zhang L 2026 Aug 24 置信度 0.82
• A Shenling Baizhu San polysaccharide fraction (SLP-2)-based synbiotic alleviates lactose-induced gut dysfunction via a microbiota-metabolite-barrier axis.
  Lactose intolerance (LI) is a common digestive disorder, and its management still relies largely on dietary restriction. Because gut microbial fermentation and barrier dysfunction contribute to LI-related symptoms, microbiota-targeted prebiotic or synbiotic st…
  pubmed Han LL, Mei CF, Lu M, Xue H 2026 Oct 31 置信度 0.82
• Enhancing ginsenoside biotransformation by engineering a thermophilic enzyme: Disulfide bond-induced activity-thermostability trade-off.
  The thermophilic β-glycosidase from Sulfolobus solfataricus (SS-Bgl) has great potential for producing rare ginsenoside CK from ginseng stems and leaves, which are rich in main ginsenosides. To enhance its thermal stability, we designed disulfide bonds b…
  pubmed Guo Y, Yu S, Li S, Wang L 2026 置信度 0.82
• Calvatia lilacina spores extract and engineered E. coli Nissle 1917 remodel the diabetic wound microenvironment through combined treatment.
  Diabetic wound healing is severely impaired by persistent inflammation and microbial dysbiosis. The study presents a combinedfunctional ingredient system centered on an engineered thymidine-auxotrophic Escherichia coli Nissle 1917 strain (ThyA -/- -EcN), whose…
  pubmed He T, Li Y, Dong T, Yuan T 等 2026 Oct 31 置信度 0.82
• Structural characterization and hypoglycemic mechanism of Chinese yam polysaccharide at the nexus of IR-AMPK-PI3K-AKT pathway in type 2 diabetic zebrafish and cellular insulin resistant model.
  Chinese yam polysaccharides (CYPS) have attracted significant interest for their potential health benefits, particularly in managing diabetes mellitus (T2DM). However, their structural characteristics, antidiabetic mechanisms in insulin-resistant cells, and ty…
  pubmed Liu X, Ahmed A, Zheng H, Wang F 等 2026 Oct 31 置信度 0.82
• Apolipoprotein B and colorectal cancer risk: Toward actionable risk stratification.
  pubmed Dong J, Jiang Y, Song J, Xu Y 2026 Aug 置信度 0.82
• Remnant cholesterol and diabetic kidney disease phenotypes: The importance of albuminuria-stratified interpretation.
  pubmed Huang Y, Wang H, Guo L 2026 Aug 置信度 0.82
• Letter to the editor regarding "severe maternal morbidity and obstetrical outcomes by twin chorionicity and amnionicity".
  pubmed Zhou Z, Dong X, Ma K 2026 Sep 置信度 0.82
• Multidimensional nutritional and body-composition phenotypes and their associations with prevalent anaemia and metabolic abnormalities in CKD: protocol for an EHR-based retrospective baseline cross-sectional study with a prospective measurement extension.
  Chronic kidney disease (CKD) is frequently accompanied by nutritional imbalance, inflammation and metabolic disturbance. Single-marker assessment may not capture the multidimensional nutritional heterogeneity of CKD. This protocol aims to derive nutritional ph…
  pubmed Tian X, Fu W, Gao Z, Ma X 等 2026 Aug 24 置信度 0.82
• Qinghuang powder ameliorates cellular senescence and energy metabolism abnormalities in bone marrow mesenchymal stem cells of myelodysplastic syndromes.
  Myelodysplastic syndromes (MDS) are haematological malignancies for which traditional Chinese medicine (TCM) has been shown to provide distinctive clinical value. Qinghuang powder (QHP), a traditional Chinese medicinal preparation, has been shown to possess si…
  pubmed Jiang P, Sun D, Zhang Y, Wang D 等 2026 Aug 24 置信度 0.82
• Nanomedicine for pancreatitis therapy: mechanism-guided design and translational challenges.
  Pancreatitis presents a formidable clinical challenge as a therapeutically underserved inflammatory disorder, where acute pancreatitis relies predominantly on supportive care and chronic pancreatitis lacks approved disease-modifying, anti fibrotic pharmacother…
  pubmed Wu X, Meng J 2026 Aug 24 置信度 0.82
• Improved oral bioavailability of dihydromyricetin using β-cyclodextrin-grafted chitosan/tocopheryl polyethylene glycol succinate nano-delivery system: preparation, characterization, in-vitro evaluation and pharmacokinetics.
  The low oral bioavailability of Dihydromyricetin(DMY), resulting from its instability and poor absorption in the gastrointestinal tract, limits its pharmaceutical applications. In order to enhance the oral bioavailability of DMY, a DMY@CD-CS/TPGS nano-delivery…
  pubmed Deng Y, Yang R, Ding W, Chen J 等 2026 Aug 24 置信度 0.82
• Plasma metabolomics improves prognostic prediction of chronic kidney disease: evidence from a large-scale population-based prospective cohort study.
  Chronic kidney disease (CKD) is a major global health concern associated with increased mortality and cardiovascular events. Traditional clinical models fail to capture the complex metabolic disturbances in CKD progression. This study aimed to assess the value…
  pubmed Jiang C, Qiu C, Li D, Zhao S 等 2026 Aug 24 置信度 0.82
• Infection-triggered surface remodeling for mucus penetration and host-pathogen reprogramming against MDR bacterial infections.
  Mucosal bacterial infections, including pneumonia and keratitis, remain challenging to treat because the viscoelastic mucus barrier severely impedes drug transport. Although PEGylation is widely employed to facilitate mucus penetration, it often masks bacteria…
  pubmed Wu X, Ye T, Wang H, Zheng J 等 2026 Aug 27 置信度 0.82