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Adaptive decision-making depends on the integration of reward valuation with internal bodily and action-related signals; yet, this broader neural architecture is not fully captured by reward-centric models. Emerging evidence suggests that bodily self-awareness…
europepmc
2026
置信度 0.80
-
Zolpidem is a widely prescribed hypnotic agent that has been reported to produce paradoxical neurological effects in a subset of patients with conditions such as disorders of consciousness and other forms of neurological injury, including transient improvement…
europepmc
2026
置信度 0.80
-
pubmed
Motosugi R, Walinda E, Kim T, Mateias AL 等
2026
置信度 0.82
-
Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by progressive cognitive and motor decline, largely driven by chronic neuroinflammation and oxidative stress. Conventional therapies primarily provid…
europepmc
2026
置信度 0.80
-
Animals must continually evaluate the relative value of social and nonsocial rewards to guide adaptive behavior. While both food and social stimuli engage overlapping reward networks, how these reward types are represented within specific nodes of the circuit …
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
Transcranial pulsed current stimulation (tPCS) is a frequency-dependent neuromodulation technique. However, its mechanisms remain unclear. This study examined the effects of low-frequency (0.5, 1, 3, 5 Hz, and sham stimulation) anodal monophasic tPCS (a-tPCS M…
europepmc
2026
置信度 0.80
-
Background Sensory processing dysfunction is linked to emotional dysregulation and anxiety in humans. While tactile deprivation is known to impair dorsal hippocampal functions (spatial memory and learning), its impact on the cytoarchitecture of limbic regions …
europepmc
2026
置信度 0.80
-
Segmentations of the vertebral column that include anatomical subregions can be used for patient education, pedicle screw planning, or radiomic feature extraction for spinal surgery. Deep learning has proven successful in tackling medical image segmentation; t…
europepmc
2026
置信度 0.80
-
Interhemispheric inhibition (IHI) reflects transcallosal interactions between bilateral primary motor cortices and is commonly assessed using a paired-pulse, transcranial magnetic stimulation (TMS) paradigm, in which a conditioning TMS pulse is delivered to M1…
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
Background Vanishing white matter is a neurodegenerative disease with onset mostly in children aged 1-6 years that causes early death and has no effective therapy. The disease is caused by a genetic defect affecting eukaryotic initiation factor 2B, a key regul…
europepmc
2026
置信度 0.80
-
Mechanisms directing meningeal lymphatic development have remained largely unexplored. Tavares et al. 1 identify macrophage-mediated sculpting as a developmental program that establishes cerebrospinal fluid drainage pathways, revealing how disrupted lymphatic …
europepmc
2026
置信度 0.80
-
Purpose Primary Brain Calcification (PBC) is a neurodegenerative disorder with marked genetic, radiological, and clinical heterogeneity. Infratentorial changes are largely unknown, and MRI role is still underinvestigated. Methods Fifty PBC patients underwent b…
europepmc
2026
置信度 0.80
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Stroke is a global health concern, requiring early and accurate diagnosis for effective treatment. Differentiating between ischaemic stroke and haemorrhagic stroke is critical, as treatment strategies differ significantly. While neuroimaging is the gold standa…
europepmc
2026
置信度 0.80
-
Introduction Electroconvulsive therapy (ECT) is the most effective intervention for depression, yet no validated biomarkers reliably predict which patients will remit. Large-scale structural and functional dysconnectivity is well-established in major depressiv…
europepmc
2026
置信度 0.80
-
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a role in hepatic cholesterol metabolism via low density lipoprotein receptor degradation. PCSK9 inhibitors have revolutionized lipid-lowering therapy, providing robust reduction of cardiovascular ris…
europepmc
2026
置信度 0.80
-
How the spatial arrangement of synaptic inputs shapes neuronal feature selectivity remains a fundamental question. Here, we map the three-dimensional distribution of excitatory and inhibitory synapses across the dendritic arbor of CA1 pyramidal neurons in vivo…
europepmc
2026
置信度 0.80
-
pubmed
Jarvie BC, Ravi A, Nanavati R, Namkung H 等
2026
置信度 0.82
-
Recent discoveries focused on the role of intraspinal pressure (ISP) in metabolite clearance after spinal cord injury (SCI) have initiated intense research on CSF inflow and outflow pathways. This study aimed to investigate whether the pulsatile ISP wave serve…
pubmed
Yuan C, Yuan F, Chang C, Wang J 等
2026
置信度 0.82
-
Spontaneous fluctuations in brain activity are thought to underlie mind-wandering, moments when mental experience becomes unrelated to what one is currently doing. A large body of research has investigated ongoing neural oscillations in the alpha band (7-14 Hz…
europepmc
2026
置信度 0.80
-
The blood-brain barrier (BBB) supporting the health of the central nervous system does this by limiting molecular exchange between circulation and brain tissue, although unfortunately this same restriction prevents therapeutically relevant macromolecules from …
europepmc
2026
置信度 0.80
-
The striatum is a major cortical input site of the basal ganglia and plays a critical role in the control of orofacial movements such as licking. However, how striatal activity relates to the spatial features of licking behavior remains unclear. In this study,…
europepmc
2026
置信度 0.80
-
Children today experience widespread circadian disruption from nighttime screen use and irregular sleep, yet how internal clocks shape brain development is unclear. Adolescence is a critical window when synaptic connectivity is refined, in part by microglia th…
europepmc
2026
置信度 0.80
-
Aging is associated with immune dysregulation in the brain and is the greatest risk factor for many neurodegenerative diseases. Rejuvenation interventions can mediate beneficial effects. Microglia are major contributors to neurodegenerative disease progression…
pubmed
Naz H, Lu N, Escoubas CC, Sager L 等
2026
置信度 0.82
-
pubmed
Pauletto G, Skrap B, Tomasino B, Lettieri C 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
-
Early and objective screening of Autism Spectrum Disorder (ASD) remains challenging because conventional diagnosis primarily relies on behavioural assessment and clinical observation. To address this limitation, this study proposes a dual-domain computational …
europepmc
2026
置信度 0.80
-
Neural representations of acoustic features that are key to speech perception have been studied extensively within the auditory cortex (AC), but their representations in higher-order cortical regions remain poorly understood. This study investigates the cortic…
europepmc
2026
置信度 0.80
-
Bone loss is an underestimated consequence of spinal cord injury (SCI), that manifests rapidly and is resistant to currently available treatments including exercise, functional electrical stimulation, anabolic agents, and bisphosphonates. While changes in adre…
europepmc
2026
置信度 0.80
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pubmed
Bruno MG, Menichetti G, Valentino A, Javaid A 等
2026
置信度 0.82
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pubmed
Descamps LAL, Clawson WP, Carvalho MM, Rogerson T 等
2026
置信度 0.82
-
In this manuscript, we report the development of a comprehensive resource designed to harness the transformative potential of patient-derived induced pluripotent stem cells (iPSCs) to advance the study of neurodevelopmental disorders (NDDs). Using CRISPR-Cas-m…
europepmc
2026
置信度 0.80
-
Neuroscience has long relied on (typically binary) categorisations to manage the complexity of brain organisation. Yet growing anatomical and physiological evidence reveals that these dichotomies artificially partition systems that are inherently continuous an…
europepmc
2026
置信度 0.80
-
The first transgenic mouse models of Alzheimer's disease (AD) developed in the 1990 s were hailed as a major breakthrough. As newer generations of models have emerged over the decades after, they still face growing criticism for translating poorly into clinica…
europepmc
2026
置信度 0.80
-
The insular cortex integrates interoceptive and exteroceptive information to mediate bodily homeostasis, emotion and learning. However, the cellular and circuit substrates governing insular functions are poorly understood compared to primary cortices. Here we …
europepmc
2026
置信度 0.80
-
Background Cardiovascular disease (CVD) is a major risk factor for cognitive decline and dementia. We examined whether a higher atherosclerotic cardiovascular disease (ASCVD) risk is associated with faster cognitive decline in Project FRONTIER, a rural cohort.…
europepmc
2026
置信度 0.80
-
Objective Functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) results indicate that primary somatosensory cortical (S1) representations vary between individuals. Here we studied how well somatosensory representations determ…
europepmc
2026
置信度 0.80
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Two contributions focus on the diversity of astrocyte morphology and its relationship to function in the healthy brain. In their review, Ciani and Falcone (2024) examine interlaminar and varicose projection astrocytes, two morphotypes found predominantly in pr…
europepmc
2026
置信度 0.80
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The central amygdala (CeA) orchestrates defensive behaviors, pain processing, and stress responses, yet how its molecularly defined neuronal subtypes are embedded in brain-wide circuits remains unclear. Here, we reconstructed the brain-wide input and output ar…
europepmc
2026
置信度 0.80
-
Background The EuroQol 5-Dimension 5-Level questionnaire (EQ-5D-5L) is widely used in health outcomes research, but its longitudinal performance in amyotrophic lateral sclerosis (ALS), particularly across international cohorts, remains poorly characterized. Th…
europepmc
2026
置信度 0.80
-
The cerebellar nuclei form the main output structures of the cerebellum and are composed of a deeply conserved set of cell types. Two excitatory cell classes, Class-A and -B, are present in each cerebellar nucleus and mediate all excitatory output of the cereb…
europepmc
2026
置信度 0.80
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Most single-unit studies of animate object processing in the primate ventral visual stream rely on passive fixation, leaving it unclear whether neuronal selectivity for socially relevant stimuli depends on behavioral context. Here, we tested whether task deman…
europepmc
2026
置信度 0.80
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Chronic intermittent hypoxia (CIH), a hallmark of obstructive sleep apnea, gives rise to cognitive deficits and sleep disruption. To investigate the role of the medial prefrontal cortex (mPFC), male mice were subjected to CIH for 4 weeks (8 h/day). Brain-wide …
europepmc
2026
置信度 0.80
-
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment for advanced Parkinson’s disease (PD)1. Clinical outcome depends on several factors, including accurate programming of stimulation settings. Conventional programming thro…
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
Background Elevated inflammatory biomarkers have been consistently associated with a subset of depressive symptoms, particularly atypical and energy-related features, as well as antidepressant treatment resistance. This evidence has supported the definition of…
europepmc
2026
置信度 0.80
-
Retinal circuits extract visual features such as color, contrast, and motion. Direction-selective (DS) circuits provide a well-studied model for understanding how the brain builds feature-selective circuits. Recent work highlights the remarkable evolutionary c…
europepmc
2026
置信度 0.80
-
openalex
Dmitri B. Chklovskii
2002-06-01
置信度 0.72
Representation (politics)PhenomenonArgument (complex analysis)IronyEpistemology
-
openalex
Brenda Milner, Larry R. Squire, Eric R. Kandel
1998-03-01
置信度 0.72
Cognitive neuroscienceNeurosciencePsychologyCognitionCognitive science
-
openalex
George F. Koob, Pietro Paolo Sanna, Floyd E. Bloom
1998-09-01
置信度 0.72
NeuroscienceAddictionPsychologyNeuroscientistMolecular neuroscience
-
The fourth edition of the work that defines the field of cognitive neuroscience, offering completely new material. Each edition of this classic reference has proved to be a benchmark in the developing field of cognitive neuroscience. The fourth edition of The …
openalex
2009-09-18
置信度 0.72
Cognitive scienceCognitionCognitive neuroscienceConsciousnessField (mathematics)
-
openalex
Fernando Lopes da Silva
2013-12-01
置信度 0.72
NeuroscienceMagnetoencephalographyElectroencephalographyCognitionPsychology
-
openalex
Quentin J. M. Huys, Tiago V. Maia, Michael J. Frank
2016-02-23
置信度 0.72
Computer scienceCognitive scienceSystems neuroscienceComputational neuroscienceBridge (graph theory)
-
Given that we live in highly complex social environments, many of our most important decisions are made in the context of social interactions. Simple but sophisticated tasks from a branch of experimental economics known as game theory have been used to study s…
openalex
James K. Rilling, Alan G. Sanfey
2010-12-02
置信度 0.72
Social decision makingPsychologySocial neuroscienceGratificationReciprocity (cultural anthropology)
-
openalex
Paul Howard‐Jones
2014-10-15
置信度 0.72
MythologyTerminologyScrutinyBridging (networking)Psychology
-
openalex
E. Eidelberg
1974-10-01
置信度 0.72
Psychology
-
In 2008, the National Institute of Mental Health (NIMH) included in its new Strategic Plan the following aim: "Develop, for research purposes, new ways of classifying mental disorders based on dimensions of observable behavior and neurobiological measures". Th…
openalex
Bruce N. Cuthbert
2014-02-01
置信度 0.72
Research Domain CriteriaWorkgroupMental healthPsychologyData science
-
How can we disentangle the neural basis of phenomenal consciousness from the neural machinery of the cognitive access that underlies reports of phenomenal consciousness? We see the problem in stark form if we ask how we can tell whether representations inside …
openalex
Ned Block
2007-12-01
置信度 0.72
ConsciousnessCognitive scienceNatural (archaeology)Neural correlates of consciousnessCognition
-
In recent years, abundant evidence from behavioral and cognitive studies and functional-imaging experiments has indicated that individuals come to understand the emotional and affective states expressed by others with the help of the neural architecture that p…
openalex
Jean Decety, Philip L. Jackson
2006-04-01
置信度 0.72
EmpathyPsychologyMechanism (biology)Social neuroscienceCognition
-
Cross-disciplinary, cutting-edge work on human empathy from the perspectives of social, cognitive, developmental and clinical psychology and cognitive/affective neuroscience. In recent decades, empathy research has blossomed into a vibrant and multidisciplinar…
openalex
2009-03-20
置信度 0.72
EmpathySocial neurosciencePsychologyNeuroscienceCognitive science
-
The rapidly growing field of cognitive neuroscience holds the promise of explaining the operations of the mind in terms of the physical operations of the brain. Some suggest that our emerging understanding of the physical causes of human (mis)behaviour will ha…
openalex
Semir Zeki, Oliver R. Goodenough, Joshua D. Greene, Jonathan D. Cohen
2004-11-29
置信度 0.72
NeurolawDoctrineTransformative learningCognitive neuroscienceNeuroeconomics
-
openalex
Lotte Meteyard, Sara Rodríguez‐Cuadrado, Bahador Bahrami, Gabriella Vigliocco
2010-11-20
置信度 0.72
Embodied cognitionPsychologyRepresentation (politics)NeuropsychologyCognitive science
-
openalex
Alfred J. Szumski
1971-12-01
置信度 0.72
Psychology
-
The discovery of the size and complexity of the human microbiome has resulted in an ongoing reevaluation of many concepts of health and disease, including diseases affecting the CNS. A growing body of preclinical literature has demonstrated bidirectional signa…
openalex
Emeran A. Mayer, Rob Knight, Sarkis K. Mazmanian, John F. Cryan 等
2014-11-12
置信度 0.72
MicrobiomeNeuroscienceGut–brain axisGut microbiomeAutism
-
Drug consumption is driven by a drug's pharmacological effects, which are experienced as rewarding, and is influenced by genetic, developmental, and psychosocial factors that mediate drug accessibility, norms, and social support systems or lack thereof. The re…
openalex
Nora D. Volkow, Michael Michaelides, Rubén Baler
2019-09-11
置信度 0.72
AddictionNucleus accumbensNeuroscienceDopamineReward system
-
openalex
Thomas R. Insel
2010-03-01
置信度 0.72
OxytocinVasopressinPsychologyNeuroscienceSocial neuroscience
-
openalex
2019-07-18
置信度 0.72
NeuroscienceMolecular neuroscienceCognitive sciencePsychologyBiology
-
This article begins the synthesis of two currently unrelated literatures: the human capital approach to health economics and the economics of cognitive and noncognitive skill formation. A lifecycle investment framework is the foundation for understanding the o…
openalex
James J. Heckman
2007-08-08
置信度 0.72
Human capitalInvestment (military)EconomicsBehavioural economicsHealth economics
-
The authors present an overview of the neural bases of emotion. They underscore the role of the prefrontal cortex (PFC) and amygdala in 2 broad approach- and withdrawal-related emotion systems. Components and measures of affective style are identified. Emphasi…
openalex
Richard J. Davidson, Daren C. Jackson, Ned H. Kalin
2000-11-01
置信度 0.72
PsychologyAffective neuroscienceAmygdalaContext (archaeology)Dysfunctional family
-
openalex
Nikolaus Kriegeskorte, Pamela K. Douglas
2018-08-10
置信度 0.72
Computational neuroscienceCognitive neuroscienceComputational modelCognitionSystems neuroscience
-
openalex
HighWire Press
1981-01-01
置信度 0.72
Social neuroscienceCognitive neuroscienceNeurosciencePsychologyCognitive science
-
Tremendous progress has been made in basic neuroscience in recent decades. One area that has been especially successful is research on how the brain detects and responds to threats. Such studies have demonstrated comparable patterns of brain-behavior relations…
openalex
Joseph E. LeDoux, Daniel S. Pine
2016-09-09
置信度 0.72
Cognitive reframingAnxietyPsychologyFeelingAffective neuroscience
-
Neuroscience has focused on the detailed implementation of computation, studying neural codes, dynamics and circuits. In machine learning, however, artificial neural networks tend to eschew precisely designed codes, dynamics or circuits in favor of brute force…
openalex
Adam Marblestone, Greg Wayne, Konrad P. Körding
2016-06-01
置信度 0.72
Computer scienceComputational neuroscienceImplementationRecursion (computer science)Artificial intelligence
-
Craver offers explicit standards for successful explanation of the workings of the brain, on the basis of a systematic view about what neuroscientific explanations are: they are descriptions of mechanisms.
openalex
Carl F. Craver
2007-01-01
置信度 0.72
Relevance (law)MosaicNeuroscienceCognitive sciencePsychology
-
openalex
P. Michael Conn
1992-01-01
置信度 0.72
Cognitive sciencePsychologyComputer science
-
Mammalian associative learning is organized into separate anatomically defined functional systems. We illustrate the organization of two of these systems, Pavlovian fear conditioning and Pavlovian eyeblink conditioning, by describing studies using mutant mice,…
openalex
Michael S. Fanselow, Andrew M. Poulos
2004-11-02
置信度 0.72
NeuroscienceAssociative learningPsychologyAmygdalaAssociative property
-
openalex
Micha E. Spira, Aviad Hai
2013-02-01
置信度 0.72
MicroelectrodeMultielectrode arrayNeuroscienceSubthreshold conductionElectrophysiology
-
openalex
2008-10-29
置信度 0.72
NeurosciencePsychologyCognitive science
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openalex
Brian J. Prendergast, Kenneth G. Onishi, Irving Zucker
2014-01-20
置信度 0.72
Estrous cycleInclusion (mineral)Behavioral neurosciencePsychologyNeuroscience
-
The ultimate aim of computational neuroscience is to explain how electrical and chemical signals are used in the brain to represent and process information. This goal is not new, but much has changed in the last decade. More is known now about the brain becaus…
openalex
Terrence J. Sejnowski, Christof Koch, Patricia Smith Churchland
1988-09-09
置信度 0.72
Computational neuroscienceNeuroscienceComputer scienceSystems neuroscienceProcess (computing)
-
The fifth edition of a work that defines the field of cognitive neuroscience, with entirely new material that reflects recent advances in the field. Each edition of this classic reference has proved to be a benchmark in the developing field of cognitive neuros…
openalex
2014-10-24
置信度 0.72
CognitionCognitive scienceCognitive neuroscienceConsciousnessField (mathematics)
-
openalex
Francis O. Schmitt, Gardner C. Quarton, Theodore Melnechuk, George Adelman 等
1970-01-01
置信度 0.72
PsychologyComputer science
-
openalex
Saurabh Sonkusare, Michael Breakspear, Christine C. Guo
2019-06-27
置信度 0.72
PsychologyNaturalismNeuroscienceCognitive scienceBehavioral neuroscience
-
openalex
Usha Goswami
2006-04-10
置信度 0.72
MisinformationNeuroscienceEducational neuroscienceCognitive neurosciencePsychology
-
This article describes a new method for assessing the effect of a given film on viewers' brain activity. Brain activity was measured using functional magnetic resonance imaging (fMRI) during free viewing of films, and inter-subject correlation analysis (ISC) w…
openalex
Uri Hasson, Ohad Landesman, B Knappmeyer, Ignacio Vallines 等
2008-01-01
置信度 0.72
Functional magnetic resonance imagingFilmmakingCognitive neuroscienceBrain activity and meditationPsychology
-
openalex
Tor D. Wager, Lauren Y. Atlas
2015-06-19
置信度 0.72
NeurochemicalNeurosciencePlaceboNeuropsychologyContext (archaeology)
-
openalex
Simon Grondin
2010-03-26
置信度 0.72
Time perceptionPerceptionPsychologyCognitive psychologyCognitive science
-
openalex
Hiroki R. Ueda, Ali Ertürk, Kwanghun Chung, Viviana Gradinaru 等
2020-01-02
置信度 0.72
ClearingNeuroscienceCognitive scienceComputer scienceBiology
-
Cerebellar neuroscience has undergone a paradigm shift. The theories of the universal cerebellar transform and dysmetria of thought and the principles of organization of cerebral cortical connections, together with neuroanatomical, brain imaging, and clinical …
openalex
Jeremy D. Schmahmann, Xavier Guell, Catherine J. Stoodley, Mark A. Halko
2019-04-02
置信度 0.72
DysmetriaNeuroscienceCerebellumPsychologyCognition
-
openalex
Martha J. Farah
2017-09-01
置信度 0.72
Socioeconomic statusPsychologyNeuroscienceSystems neuroscienceSocial neuroscience
-
Learned helplessness, the failure to escape shock induced by uncontrollable aversive events, was discovered half a century ago. Seligman and Maier (1967) theorized that animals learned that outcomes were independent of their responses-that nothing they did mat…
openalex
Steven F. Maier, Martin E. P. Seligman
2016-06-24
置信度 0.72
Learned helplessnessDorsal raphe nucleusNeurosciencePsychologyPrefrontal cortex
-
openalex
Chris Chambers, Hugh Garavan, Mark A. Bellgrove
2008-09-12
置信度 0.72
NeuroscienceCognitionCognitive neurosciencePsychologyResponse inhibition
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Understanding causal relationships, or effective connectivity, between parts of the brain is of utmost importance because a large part of the brain's activity is thought to be internally generated and, hence, quantifying stimulus response relationships alone d…
openalex
Raúl Vicente, Michael Wibral, Michael Lindner, Gordon Pipa
2010-08-12
置信度 0.72
Transfer entropyComputer scienceGranger causalityMagnetoencephalographyEntropy (arrow of time)
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openalex
Christoph Schmitz, Patrick R. Hof
2004-11-12
置信度 0.72
StereologyCytoarchitectureNeuroscienceConfusionComputer science
-
Rapid advancements in human neuroscience and neurotechnology open unprecedented possibilities for accessing, collecting, sharing and manipulating information from the human brain. Such applications raise important challenges to human rights principles that nee…
openalex
Marcello Ienca, Roberto Andorno
2017-04-03
置信度 0.72
Human rightsContext (archaeology)Relevance (law)Unintended consequencesOpen science
-
The fourth Intensive Study (ISP) of MIT's Neurosciences Research was held in the summer of 1977. Previous volumes developed from ISPs have formed focal points in the evolution of the field of neuroscience, and the present volume continues this tradition of exc…
openalex
Francis O. Schmitt, Frederic G. Worden, George Adelman, Blair H. Smith 等
1979-01-01
置信度 0.72
NeuroscienceNeuropilNeuronal circuitsBiological neural networkCognitive science
-
Network science provides theoretical, computational, and empirical tools that can be used to understand the structure and function of the human brain in novel ways using simple concepts and mathematical representations. Network neuroscience is a rapidly growin…
openalex
John D. Medaglia, Mary-Ellen Lynall, Danielle S. Bassett
2015-03-24
置信度 0.72
CognitionCognitive neuroscienceCognitive scienceComputational neuroscienceSystems neuroscience
-
openalex
E. Eidelberg
1971-09-01
置信度 0.72
Psychology
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openalex
Karel Svoboda, Ryohei Yasuda
2006-06-01
置信度 0.72
PhotostimulationMicroscopyNeuroscienceFluorescence microscopeTwo-photon excitation microscopy