基因技术工具 · 全部实体（第 90 / 100 页）

本页收录第 8901–9000 条，共 10000 条 · 返回 基因技术工具 首页

• IMAGE: INTEGRATE-Mediated <i>Agrobacterium</i> Genome Engineering.
  europepmc 2025 置信度 0.80
• PHYCUT: Scalable Multiplex CRISPR/Cas9 Editing for Genome Engineering in the Diatom <i>Phaeodactylum tricornutum</i>.
  europepmc 2026 置信度 0.80
• Periplasmic SacB as a robust counter-selection tool for genome engineering in the polyploid bacterium <i>Zymomonas mobilis</i>.
  europepmc 2026 置信度 0.80
• TRU-PE: A Universal, Trackable Prime Editor Toolkit for Robust Single- and Multi-Locus Genome Engineering
  europepmc 2026 置信度 0.80
• Blockchain Technology for Big-data Sharing in Material Genome Engineering.
  europepmc 2025 置信度 0.80
• Building tolerance: employing genome engineering toward universal Treg therapy.
  europepmc 2025 置信度 0.80
• CrisprBuildr: an open-source application for CRISPR-mediated genome engineering in Drosophila melanogaster.
  europepmc 2026 置信度 0.80
• Discovery of a Novel Chimeric Transposase-Transposon System for Advanced Genome Engineering
  europepmc 2025 置信度 0.80
• OmniEdit: A unified CRISPR/Cas9 platform for precise genome engineering and strain optimization of the <i>Cordyceps militaris</i> cell factory.
  europepmc 2026 置信度 0.80
• Unlocking genome engineering in <i>Alcaligenes faecalis</i> by exploiting its native type I-F CRISPR-Cas.
  europepmc 2026 置信度 0.80
• Recent progress in plant genome engineering: from large insertions to chromosome number changes.
  europepmc 2026 置信度 0.80
• Biparental plastid inheritance and its implications in plastid genome engineering.
  europepmc 2025 置信度 0.80
• Modulating Complex Secondary Metabolism in <i>Streptomyces rimosus</i> by Targeted Genome Engineering.
  europepmc 2026 置信度 0.80
• Physical stimuli-responsive CRISPR-Cas9 systems for spatiotemporally precise control of genome engineering.
  europepmc 2026 置信度 0.80
• A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording.
  europepmc 2025 置信度 0.80
• CRISPR 2.0: Expanding the genome engineering Toolbox for epigenetics, RNA editing, and molecular diagnostics.
  europepmc Khushboo Pradhan, Sindhu Anoop 2025-12-05T00:33:07Z 置信度 0.80
• Development and characterization of a Cre/<i>loxP</i> toolkit for genome engineering in <i>Komagataella phaffii</i>.
  europepmc 2027 置信度 0.80
• AlphaFold3-guided optimization of a photoactivatable endonuclease for top-down genome engineering.
  europepmc 2025 置信度 0.80
• StreptoCAD: An Open-Source Software Toolbox Automating Genome Engineering Workflows in Streptomycetes.
  europepmc 2025 置信度 0.80
• Integrated Tn-seq and MAGE-assisted rapid genome engineering targeting in Escherichia coli.
  europepmc 2026 置信度 0.80
• 3D Genome Engineering: Current Advances and Therapeutic Opportunities in Human Diseases.
  europepmc 2025 置信度 0.80
• Defect-complementation homologous recombination: A novel strategy for precise genome engineering of virulent phages.
  europepmc 2026 置信度 0.80
• Programmable genome engineering and gene modifications for plant biodesign.
  europepmc 2025 置信度 0.80
• CRISPR/Cas9 and Cytidine Base-Editing Systems for Efficient Genome Engineering in Oleaginous <i>Rhodococcus</i>.
  europepmc 2026 置信度 0.80
• Advancing Fast-Track Genome Engineering in <i>Bacillus subtilis</i> Phages.
  europepmc 2026 置信度 0.80
• Multilayered epigenetic regulation of iron homeostasis in plants: From chromatin remodeling to genome engineering.
  europepmc 2025 置信度 0.80
• Iterative Genome Engineering Platform Enables Efficient Sucrose Biosynthesis From CO<sub>2</sub> in Photosynthetic Synechococcus elongatus UTEX 2973.
  europepmc 2026 置信度 0.80
• DNA-PKcs inhibitor AZD7648 reveals sgRNA cross-contaminants and enhanced sensitivity of genome engineering off-target activity in HSPCs.
  europepmc 2026 置信度 0.80
• Programming virulent bacteriophages by developing a multiplex genome engineering method.
  europepmc 2025 置信度 0.80
• Combinatorial genome engineering of pseudorabies virus Bartha by developing a reverse genetic system based on three overlapping genomic segments.
  europepmc 2025 置信度 0.80
• Iterative recombinase technologies for efficient and precise genome engineering across kilobase to megabase scales.
  europepmc 2025 置信度 0.80
• Decoding genetic diversity through genome engineering in bryophytes.
  europepmc 2025 置信度 0.80
• Harnessing transposable elements for plant functional genomics and genome engineering.
  europepmc 2025 置信度 0.80
• Mouse genome engineering uncovers 18 genes dispensable for male reproduction.
  europepmc 2026 置信度 0.80
• Genome Engineering, Chemical Exposure, and the Germline: An Ethical Synthesis.
  europepmc 2025 置信度 0.80
• Site-specific genome engineering of primary human natural killer cells for programmable anti-tumor function
  europepmc 2025 置信度 0.80
• Make-or-break prime editing for genome engineering in Streptococcus pneumoniae.
  europepmc 2025 置信度 0.80
• Computational genome engineering through AI-CRISPR-precision medicine integration in modern therapeutics.
  europepmc 2025 置信度 0.80
• Combinatorial pathway engineering using multiplex Serine recombinase-Assisted Genome Engineering (mSAGE)
  europepmc 2025 置信度 0.80
• The evolution of DNA sequencing with microfluidics.
  europepmc 2025 置信度 0.80
• Structural variations in evolutionary novel genomic regions: new insights into neurodevelopmental disorders by long-read DNA Sequencing.
  europepmc 2026 置信度 0.80
• A set cover algorithm identifies minimal circulating tumour DNA sequencing targets for colorectal cancer detection.
  europepmc 2025 置信度 0.80
• Integrative modeling of read depth and B-allele frequency improves single-cell copy number calling from targeted DNA sequencing panels
  europepmc 2026 置信度 0.80
• Image-based DNA sequencing encoding for detecting low-mosaicism somatic mobile element insertions.
  europepmc 2025 置信度 0.80
• Fast, cost-effective and flexible DNA sequencing by roll-to-roll fluidics.
  europepmc 2025 置信度 0.80
• Whipple's endocarditis diagnosed non-invasively with plasma microbial cell-free DNA sequencing.
  europepmc 2025 置信度 0.80
• MitoCOMON: whole mitochondrial DNA sequencing by primer design and long overlapping amplicon assembly.
  europepmc Yoshikazu Furuta, Manami Kakita, Hidenori Tanaka 2025 置信度 0.80
• Enhanced Detection of EGFRvIII in Tumors: A Comparative Study of Split Read- and Read Depth-Based DNA Sequencing Approaches.
  europepmc 2026 置信度 0.80
• Microbial next generation DNA sequencing of aspirated synovial fluid shows concordance with ICM criteria biomarkers for diagnosing periprosthetic joint infection in hip and knee arthroplasty.
  europepmc 2026 置信度 0.80
• Evaluating Contamination Risk When Aspirating a Prosthetic Joint Using Microbial Next-Generation DNA Sequencing: An In Vitro Study.
  europepmc 2025 置信度 0.80
• Brain tumor detection based on transcription regulation features identified from public cerebrospinal fluid cell-free DNA sequencing data.
  europepmc 2026 置信度 0.80
• Whole exome sequencing and single-cell DNA sequencing for assessment of clonal heterogeneity and evolution in acute myeloid leukemia.
  europepmc 2025 置信度 0.80
• From air to insight: the evolution of airborne DNA sequencing technologies.
  europepmc 2025 置信度 0.80
• Unraveling the Genome Diversity of <i>Leishmania</i> Parasites Using Next-Generation DNA Sequencing Strategies.
  europepmc 2025 置信度 0.80
• SNACS: a tool for demultiplexing single-cell DNA sequencing data.
  europepmc 2025 置信度 0.80
• Long-read DNA sequencing resolves a rare case of alloimmune hemolysis mimicking autoimmune hemolysis.
  europepmc 2025 置信度 0.80
• Pharming: Joint Clonal Tree Reconstruction of Single-Nucleotide Variant and Copy Number Aberration Evolution from Single-Cell DNA Sequencing of Tumors.
  europepmc 2026 置信度 0.80
• Advances and Challenges in Solid-State Nanopores for DNA Sequencing.
  europepmc 2025 置信度 0.80
• DNA sequencing of type material of Polyopes constrictus and Dermocorynus occidentalis (Halymeniales, Rhodophyta) supports Polyopes capensis sp. nov. and Polyopes occidentalis (Hollenberg) comb. nov.
  europepmc 2026 置信度 0.80
• Nanopore-Aware Embedded Detection for Mobile DNA Sequencing: A Viterbi-HMM Design Versus Deep Learning Approaches.
  europepmc 2025 置信度 0.80
• DNA Sequencing and the Third-Generation Sequencing Revolution.
  europepmc 2025 置信度 0.80
• Massively parallel immunopeptidome by DNA sequencing provides insights into cancer antigen presentation.
  europepmc 2025 置信度 0.80
• Comparative study of plasma microbial cell-free DNA sequencing to culture and polymerase chain reaction in pediatric community-acquired pneumonia with parapneumonic effusion or empyema.
  europepmc 2026 置信度 0.80
• Murine Typhus in Heart and Kidney Transplant Recipients: First Reported Cases Diagnosed by Microbial Cell-Free DNA Sequencing.
  europepmc 2025 置信度 0.80
• Plasma microbial cell-free DNA sequencing in transplant and haematologic patients-promise, pitfalls, and path forward.
  europepmc 2026 置信度 0.80
• RadiSeq: a single- and bulk-cell whole-genome DNA sequencing simulator for radiation-damaged cell models.
  europepmc 2025 置信度 0.80
• From Suspected to Rejected: Role of Serial Plasma Microbial Cell-Free DNA Sequencing as a Diagnostic Adjunct in CIED Infections.
  europepmc 2025 置信度 0.80
• Advance in the assembly of the plant mitochondrial genomes using high-throughput DNA sequencing data of total cellular DNAs.
  europepmc 2025 置信度 0.80
• Improved circulating tumor DNA profiling by simultaneous extraction of DNA methylation and copy number information from methylated DNA sequencing data.
  europepmc 2025 置信度 0.80
• Comparative diagnostic performance of plasma microbial cell-free DNA sequencing versus amplicon-based blood next-generation sequencing in suspected bloodstream or endovascular infection: a single-center study.
  europepmc 2026 置信度 0.80
• Advances in single-cell DNA sequencing enable insights into human somatic mosaicism.
  europepmc 2025 置信度 0.80
• A novel high-throughput single-cell DNA sequencing method reveals hidden genomic heterogeneity in the unicellular eukaryote <i>Leishmania</i>
  europepmc 2025 置信度 0.80
• Amplicon-based DNA sequencing to characterize Duffy antigen polymorphisms and analysis of Duffy blood system and glucose-6-phosphate dehydrogenase deficiency in Mauritania.
  europepmc 2025 置信度 0.80
• Nanopore-based sensors for DNA sequencing: a review.
  europepmc 2024 置信度 0.80
• Author Correction: DNA sequencing at the picogram level to investigate life on Mars and Earth.
  europepmc 2025 置信度 0.80
• Pharms on farms: Variable impacts of veterinary pharmaceuticals on an arbuscular mycorrhizal symbiosis and soil microorganisms.
  Circular agriculture promotes the reuse of organic waste, such as animal manures, to reduce reliance on synthetic fertilisers. However, manures can introduce veterinary pharmaceuticals into soils. Arbuscular mycorrhizal (AM) fungi are critical for plant nutrit…
  pubmed Durant EK, Carter LJ, Edmondson JL, Field KJ 2026 置信度 0.82
• Feasibility of routine clinical liquid-based cytology for lung cancer compact panel testing.
  The Lung Cancer Compact Panel (cPANEL) is a recently approved highly sensitive multiplex gene panel in Japan that supports both DNA- and RNA-based next-generation sequencing. Although cytological specimens are acceptable for cPANEL, unfixed cell pellets or ded…
  pubmed Shinomiya Y, Hatanaka KC, Okumura A, Nange A 等 2026 Sep 置信度 0.82
• Temperature and Ultraviolet Radiation Influence the Skin Microbiome of Humpback Whales.
  The skin microbiome of humpback whales harbours diverse microbial communities that play a crucial role in host skin protection and environmental interaction. However, studies on cetacean skin microbiomes in the Southern Hemisphere focus on feeding grounds, wit…
  pubmed Murillo-Herrera AI, Eguiarte LE, Acuña Gómez EP, Castro C 等 2026 Aug 置信度 0.82
• YAP/TEAD complex restricts H3K27ac deposition to suppress testosterone synthesis in adult Leydig cells.
  The Hippo signaling pathway regulates the development of multiple organs, yet its role in the maturation of adult Leydig cells and testosterone synthesis is unclear. In this study, by integrating bulk RNA sequencing and immunohistochemistry, we characterized t…
  pubmed Lin Z, Luo S, Zheng M, Lin Z 等 2026 Aug 5 置信度 0.82
• Neuroinflammation as molecular landscape of post-operative delirium revealed by live human brain multi-omics profiling.
  Post-operative delirium (POD) is a serious complication of surgery particularly in older adults, characterized by acute disturbances in consciousness and cognition and associated with increased mortality and long-term cognitive impairment. Despite its clinical…
  pubmed Ishii T, Wang T, Shibata K, Nishitani S 等 2026 Aug 5 置信度 0.82
• [Chinese expert consensus on the diagnosis and treatment of pneumoconiosis complicated with tuberculosis].
  Pneumoconiosis complicated with pulmonary tuberculosis is characterized by high prevalence and disability rates, as well as difficulty in early diagnosis, constituting a serious public health problem. The Chinese Society of Tuberculosis (Chinese Medical Associ…
  pubmed Chinese Society of Tuberculosis, Chinese Medical Association, Society of Labor Hygiene and Occupational Diseases, Chinese Preventive Medicine Association 2026 Aug 12 置信度 0.82
• Methylation histology reveals the molecular mechanism by which red light-mediated DNA methylation delays leaf senescence in Pak Choi (Brassica rapa subsp. chinensis).
  Leaf senescence is a key factor affecting the post-harvest quality and shelf life of vegetables. The specific mechanisms by which light environment and DNA methylation mediate leaf senescence remain unclear. This study explored the molecular mechanism by which…
  pubmed Xu Y, Ling J, Zhou H, Zhang Y 等 2026 Aug 6 置信度 0.82
• Revisiting Diffuse Gliomas in the Era of Precision Medicine: Molecular Insights and Therapeutic Implications.
  Diffuse gliomas are aggressive and lethal tumors of the Central Nervous System characterized by high molecular complexity and heterogeneity, infiltrative growth and resistance to therapy. The advent of Next-Generation Sequencing integrated molecular profiling …
  pubmed Massimino M, Stella S, Di Grazia G, Tomarchio C 等 2026 Aug 5 置信度 0.82
• Comparison of paralog identification methods and their impact on species tree topologies in target capture phylogenomics within the Sindora clade (Detarioideae: Leguminosae).
  Target capture is a common method of generating high throughput DNA sequencing data for phylogenetic reconstruction of species relationships, for which single copy genes are usually most informative. However, a pervasive problem with target capture is that put…
  pubmed Choo LM, de la Estrella M, Schley RJ, Tennant RK 等 2026 Aug 5 置信度 0.82
• An Integrative Morphological and Genomic Analysis With a Refined FISH Threshold and Novel Kinase Fusions in a Large Asian Cohort of Spitzoid Neoplasms.
  Differentiating atypical Spitz tumors (AST) from true Spitz melanomas (SM) and conventional melanomas with spitzoid features (MSF) remains a formidable diagnostic challenge. Because current molecular epidemiological data are overwhelmingly derived from Caucasi…
  pubmed Ren M, Lv N, Lv J, Wang Z 等 2026 Aug 5 置信度 0.82
• PPARβ/δ priming enhances mesenchymal stromal cell anti-apoptotic properties on chondrocytes via ANGPTL4 and improves their therapeutic effects in osteoarthritis.
  Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation, chondrocyte apoptosis, and inflammation. Mesenchymal stromal cells (MSCs) offer therapeutic potential, but their efficacy is hindered by oxidative stress and functional…
  pubmed Terraza-Aguirre C, Contreras-López R, Bernard C, Pradenas C 等 2026 Jul 20 置信度 0.82
• The neutrophil-NETs-elastase axis drives pulmonary lymphatic endothelial injury and aggravates acute lung injury.
  Acute lung injury (ALI) is a severe lung disease marked by strong neutrophil-related inflammation and pulmonary edema. However, how activated neutrophils damage pulmonary lymphatic function during ALI remains unclear. In this study, we used an LPS-induced ALI …
  pubmed Chen J, Mei Y, Yang Y, Gao X 等 2026 Aug 5 置信度 0.82
• Lesion viral burden, multidrug-resistant superinfection, and HIV-associated haematological vulnerability in hospitalised clade Ib mpox: a prospective cohort study in Uganda.
  Mpox has shifted to sustained human-to-human transmission across Africa, yet integrated triage incorporating viral burden, bacterial co-infection, antimicrobial resistance (AMR), HIV status, and routine biomarkers remain scarce.
  pubmed Serwanga J, Kaweesa RE, Odoch G, Nairuba B 等 2026 Aug 5 置信度 0.82
• Targeting a novel metabolic vulnerability of non-small cell lung cancer to fatty acid oxidation surmounts chemoresistance.
  Non-small cell lung cancer (NSCLC) patients treated with platinum drugs develop chemoresistance. C/EBP&#x3b2; has alternative translational LAP and LIP isoforms which impact cancer chemoresistance by modulating ABC efflux transporter expression and activity. D…
  pubmed Fontana S, Belisario DC, Giannotta C, Alessandri L 等 2026 Aug 2 置信度 0.82
• A Simplified Workflow for the Prediction of Putative Viral Reads Using NIPT Data.
  Non-invasive prenatal testing (NIPT) identifies fetal chromosomal abnormalities by sequencing cell-free fetal DNA (cffDNA). Recent studies suggest the prediction of viral sequences from NIPT data, but current methods lack cost-effectiveness for routine use. Th…
  pubmed Shahidi S, Dabiri Oskoei A, Mohammadzadeh A, Mirshahabi H 等 2026 Aug 5 置信度 0.82
• Zika virus positivity in Aedes aegypti mosquitoes and its genomic landscape from Pune, Western India.
  Background and objectives Zika virus cases were confirmed from Pune, Western India, during an outbreak in June 2024. We conducted an entomological investigation in the Pune municipal corporation area and aimed to characterise the Zika virus from Aedes aegypti …
  pubmed P R S, Raje M, Kumar S, Das T 等 2026 Aug 置信度 0.82
• A transposon-derived transcription factor senses ionic stress through phase separation to govern plant autophagy.
  Salt stress severely impairs plant growth through two distinct cellular insults: osmotic stress caused by water limitation and ionic toxicity resulting from excessive Na + accumulation. Although plant osmosensors have been identified, the mechanisms underlying…
  pubmed Shao Y, Wang S, Liang L, Gong B 等 2026 Aug 11 置信度 0.82
• The case for caution in the application of whole-exome sequencing data for immune repertoire analysis.
  The analysis of the adaptive immune receptor repertoire is critical in disease research. While specialized immune repertoire sequencing (IR-seq) is the dedicated method for receptor repertoire profiling, the abundance of existing WES data has led to its freque…
  pubmed Gong Z, Zhang W, Du B, Wu H 等 2026 Jul 3 置信度 0.82
• History of Population Formation for the Red Fox Around the Japanese Archipelago, Revealed by Ddrad-Seq Analysis.
  The red fox ( Vulpes vulpes ), which is widely distributed across the Northern Hemisphere, including Japan, has been studied for its distribution patterns and migration timing, but its population demography remains poorly understood. To solve it, this study co…
  pubmed Tomita R, Endo Y, Amaike Y, Uraguchi K 等 2026 Jun 置信度 0.82
• Evolution of Vanadium-Binding Protein (Vanabin) Gene Structure in Phlebobranchia and Aplousobranchia Ascidian Lineages.
  Ascidians within order Phlebobranchia can accumulate extremely high levels of vanadium (V) in their blood cells. Several V-related proteins, including V-binding proteins (vanabins), have been isolated from V-accumulating ascidians. Vanabins were first isolated…
  pubmed Adi TK, Fujie M, Satoh N, Ueki T 2026 Jun 置信度 0.82
• Pediatric ependymoma in the molecular era: real-world experience with diagnostic correlation and long-term clinical outcomes.
  Real-world longitudinal data documenting the diagnostic impact of DNA methylation array (MA) profiling in pediatric ependymoma remain sparse. We report a single-center retrospective analysis evaluating MA-driven reclassification, molecular subgroup distributio…
  pubmed Trkova K, Vicha A, Sumerauer D, Ghasemi DR 等 2026 Aug 5 置信度 0.82
• Whole genome sequencing and annotation of a non-pathogenic Fusarium brachygibbosum TZ1MST22 strain isolated from Medicago sativa in Southern Tunisian oases.
  Fusarium sambucinum species complex (FSAMSC) includes not only major mycotoxin-producing pathogens but also non-pathogenic endophytic species that can promote plant growth and stress tolerance. However, the molecular mechanisms underlying these contrasting lif…
  pubmed Ben Alaya A, Lekired A, Chaouachi M, Khiari B 等 2026 Aug 5 置信度 0.82
• Staphylococcus xeri sp. nov., a haemolytic bacterium isolated from the nasal cavity's discharge of a Cape ground squirrel (Xerus inauris).
  Strain 17KM0847 T , isolated from the nasal discharge of a dead captive Cape ground squirrel ( Xerus inauris ), is a Gram-positive, oxidase-negative, catalase-positive and coagulase-negative coccoid bacterium. It grows under both aerobic and anaerobic conditio…
  pubmed Belhout C, Thomann A, Rossano A, Collaud A 等 2026 Aug 置信度 0.82
• The genome, transcriptome and metabolome of Aspergillus welwitschiae Ocstreb1 from wild halophytic rice, Oryza coarctata, indicates its distinctiveness.
  Aspergillus welwitschiae is a widespread fungus with diverse roles as a plant mutualist, opportunistic human pathogen and industrial enzyme producer. The endophytic strain AwOcstreb1, isolated from halophytic rice ( Oryza coarctata ), promotes growth in commer…
  pubmed Tamanna N, Alam MNU, Airin AA, Shozib HB 等 2026 Aug 置信度 0.82
• Labyrinthula merlionensis sp. nov.: A Novel Labyrinthulid Infecting Marine Diatoms.
  Labyrinthulomycetes are a class of fungus-like heterotrophic protists from the Stramenopiles lineage, recognized for their ecological role as decomposers and contributors to nutrient cycling. They colonize various substrates, from seaweed to terrestrial enviro…
  pubmed Sim CWH, Walde M, Strindberg H, Kaur A 等 2026 Sep-Oct 置信度 0.82