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Patrick Corsi, Dominique Morin
2015-12-19T07:03:38Z
置信度 0.70
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Andy Brass
2023-06-07T17:37:53Z
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Nicolette Halloran, Zijin Du, Richard K Wilson
2003-11-14T21:04:50Z
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A fundamental understanding of DNA structure and function has contributed significantly to our knowledge of genetics. The DNA sequence is a key factor that underlies all inherited traits, making DNA sequence analysis a powerful tool for studying genetics. DNA …
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Rhitisha Sood, Vivek Singh
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This chapter looks at DNA sequencing, a technique used to determine the precise order of the nucleotide bases-adenine, guanine, cytosine, and thymine-in a DNA fragment. The chapter explains the first-generation sequencing methods: the chemical method introduce…
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F.J.M. IRIS
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Harry Cuppens, Jean-Jacques Cassiman
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W.R. McCOMBIE
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2025-04-03T04:33:22Z
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R.P. Haugland
2008-02-07T22:44:17Z
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Abstract The filamentous bacteriophage presents a unique mode of cloning. Double-stranded foreign DNA can be cloned into the replicative form (RF) phage DNA and, upon transformation, only one of the two strands is packaged into the viral coat (1), Therefore, s…
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2023-11-03T19:32:06Z
置信度 0.70
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This is a brief history of my experience with nanopore sequencing over the past [almost] five years, where I talk about things that have inspired me to keep playing around with the MinION, despite its somewhat quirky behaviour. It's amazing to see that the Min…
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David Eccles
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2021-12-13T03:48:02Z
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Dr Luke Alphey
2023-06-07T17:37:53Z
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2021-08-25T05:52:35Z
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Abstract We show that the fine oscillatory structure of the DNA melting curve can be used to determine explicitly the nucleotide composition and the order of certain domains within the DNA. If DNA is specifically fragmented, the order of fragments can be learn…
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M. Ya. Azbel
2004-12-30T02:27:47Z
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2021-08-25T05:52:35Z
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Abstract There are two principal methods for determining the sequence of DNA. These are based either on specific chemical degradation of a DNA molecule labelled at one end (the Maxam and Gilbert method) or on the enzymatic synthesis of labelled DNA, using dide…
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L.-I. LIU, R.D. FLEISCHMANN
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europepmc
2026
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europepmc
2026
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europepmc
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europepmc
2026
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europepmc
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europepmc
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europepmc
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europepmc
2025
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europepmc
2026
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europepmc
2026
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europepmc
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europepmc
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europepmc
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europepmc
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europepmc
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europepmc
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europepmc
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europepmc
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europepmc
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europepmc
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europepmc
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europepmc
2026
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europepmc
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europepmc
2026
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2026
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europepmc
2026
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europepmc
2026
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europepmc
2026
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europepmc
2026
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europepmc
2026
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europepmc
2026
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europepmc
2025
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europepmc
2026
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europepmc
2026
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europepmc
2025
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2025
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europepmc
2026
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europepmc
2026
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europepmc
2025
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europepmc
2026
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europepmc
2025
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europepmc
2026
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europepmc
2026
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europepmc
2026
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europepmc
2026
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europepmc
2026
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europepmc
2026
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europepmc
2025
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europepmc
2025
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europepmc
2026
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europepmc
2026
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europepmc
2025
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europepmc
2026
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europepmc
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europepmc
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This chapter evaluates pathogen genomics. As scientists developed sequencing tools at the end of the 1970s, virus genomes were the first to be tackled, because of their small size. Viruses, and then bacteria, formed the test bed for developments that went on t…
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M. Medina, J.L. Sachs
2010-08-20T06:41:00Z
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The term ‘genome’ is used to refer to the sum total of DNA inside the single or multiple cells that make up an organism. Complex organisms often have more than one genome. ‘What is genomics?’ looks at the biology of the two main types of cells—prokaryotes and …
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John Archibald
2018-03-22T11:02:07Z
置信度 0.70
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This chapter focuses on parasite genomics. Parasitic infections may have beneficial effects on our immune systems, and the possibility that parasites have the potential to deliver previously unrecognized benefits as well as causing devastating harm makes it ev…
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2023-09-15T07:40:11Z
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Derek Anane
2016-03-02T09:22:20Z
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2024-09-03T18:29:28Z
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This chapter discusses cancer genomics, which is one of the fastest-moving areas of medical research and is having a direct impact on people's lives. Cancer is a disease in which cells divide in excess, generating a lump, known as the primary tumour. A key fea…
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Lia Chappell, Sarah J Lindsay, Phil Jones, Julian Parkhill 等
2023-09-15T13:33:22Z
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This chapter examines the role of genetics and genomics in cancer development, focusing on how hereditary, environmental, and random factors contribute to oncogenesis. It explains how genetic mutations provide abnormal cells with a growth advantage, allowing t…
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Heather Williams, Zoe Hatt
2025-12-10T16:32:03Z
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