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• Multi-scale reactor designs extend the physical limits of CO ₂ fixation
  europepmc 2024 置信度 0.80
• Engineering Bacterial Biomanufacturing: Characterization and Manipulation of <i>Sphingomonas sp.</i> LM7 Extracellular Polymers
  Abstract Biologically produced materials are an attractive alternative to traditional materials such as metals and plastics and offer improved functionalities such as better biodegradability and biocompatibility. Polysaccharides are an example of a biologicall…
  pubmed Ellen W. van Wijngaarden, Alexandra G. Goetsch, Ilana L. Brito, David M. Hershey 等 2024 置信度 0.82
• Hyperporous encapsulation of microbes for whole cell biocatalysis and biomanufacturing
  Abstract Compared to traditional synthetic chemical processes, biocatalysts offer a more sustainable and eco-friendly approach to producing complex molecules. In particular, whole-cell biocatalysts boast numerous advantages, including scalable, self-containing…
  preprints Jingyi Zhang, Keziah Chang, Joyce Tay, Elaine Tiong 等 2024 置信度 0.74
• Metabolic engineering of <i>Acinetobacter baylyi</i> ADP1 for efficient utilization of pentose sugars and production of glutamic acid
  preprints 2025 置信度 0.74
• Demonstrating the Effectiveness of an Alternative to Triton™ X-100 for Detergent-Mediated Viral Inactivation in Biomanufacturing
  Detergent-mediated viral inactivation is an important process step for ensuring viral safety of parenteral biotherapeutics, including plasma proteins and monoclonal antibodies (mAb). The conventional Triton™ X-100 detergent has ecological toxicity concerns and…
  preprints Kakolie Banerjee, Alice Antonello, Sandra Johnson, Anja Licht 等 2024 置信度 0.74
• Engineered Cardiac Microtissue Biomanufacturing Using Human Induced Pluripotent Stem Cell Derived Epicardial Cells
  Abstract Epicardial cells are a crucial component in constructing in vitro 3D tissue models of the human heart, contributing to the ECM environment and the resident mesenchymal cell population. Studying the human epicardium and its development from the proepic…
  pubmed Kirk Butler, Saif Ahmed, Justin Jablonski, Tracy A. Hookway 等 2024 置信度 0.82
• Methanol biotransformation for the production of the biodegradable plastic monomer L-lactate in yeast
  preprints 2025 置信度 0.74
• Simulating big mechanically-active culture systems (BigMACS) using paired biomechanics-histology FEA modelling to derive mechanobiology design relationships
  preprints 2024 置信度 0.74
• A Design of Experiments Approach for Enhancing Room Temperature Stability of a Lyophilised and Paper-Based Bacterial Cell-Free System
  preprints 2025 置信度 0.74
• A Rapid and Modular Nanobody Assay for Plug-and-Play Antigen Detection
  preprints 2025 置信度 0.74
• From Spheroids to Bioprinting: A Literature Review on Biomanufacturing strategies of 3D In vitro Osteosarcoma Models 
  Osteosarcoma (OS) is a rare primary malignant bone cancer affecting mainly young individuals. Treatment typically consists of chemotherapy and surgical tumor resection, which has undergone few improvements since the 1970s. This therapeutic approach encounters …
  preprints Margarida Domingues, João C. Silva, Paola Sanjuan-Alberte 2024 置信度 0.74
• Long-term homeostasis in microbial consortia via auxotrophic cross-feeding
  preprints 2025 置信度 0.74
• Developing a model system to sustain ex vivo chloroplast function
  preprints 2025 置信度 0.74
• Elucidation of gene clusters underlying withanolide biosynthesis in ashwagandha through yeast metabolic engineering
  preprints 2024 置信度 0.74
• Synthetic ratio computation for programming population composition and multicellular morphology
  preprints 2025 置信度 0.74
• Sigma factors as potential targets to enhance recombinant protein expression
  preprints 2024 置信度 0.74
• Scalable cell-free production of active T7 RNA polymerase
  preprints 2024 置信度 0.74
• Functional plasticity of HCO ₃ ^- uptake and CO ₂ fixation in <i>Cupriavidus necator</i> H16
  preprints 2024 置信度 0.74
• Perspectives for Using CO2 as a Feedstock for Biomanufacturing
  Microbial cell factories offer an eco-friendly alternative for transforming raw materials into commercially valuable products, primarily because of their reduced carbon impact compared to conventional industrial procedures. These systems often depend on lignoc…
  preprints Elif Kurt, Jiansong Qin, Alexandria R Williams, Youbo Zhao 等 2023 置信度 0.74
• A community-consensus reconstruction of Chinese Hamster metabolism enables structural systems biology analyses to decipher metabolic rewiring in lactate-free CHO cells
  preprints 2025 置信度 0.74
• Synthetic metabolic pathways for ethylene glycol assimilation outperform natural counterparts
  preprints 2024 置信度 0.74
• Efficient production of salicylic acid through CmeR-PcmeO biosensor-assisted multiplexing pathway optimization in Escherichia coli
  preprints 2024 置信度 0.74
• COSMOS: COmmunity and Single Microbe Optimisation System
  preprints 2024 置信度 0.74
• Synthetic ratio computation for programming population composition and multicellular morphology
  preprints 2024 置信度 0.74
• Synthetic G-quadruplex components for predictable, precise two-level control of mammalian recombinant protein expression
  preprints 2024 置信度 0.74
• An innovative fixed bed bioreactor platform for linearly scalable, biomass predictable, single-use adherent cell biomanufacturing
  preprints 2023 置信度 0.74
• Enhancing Plant Photosynthesis using Carbon Dots as Light Converter and Photosensitizer
  preprints 2024 置信度 0.74
• Continuous evolution of a halogenase enzyme with improved solubility and activity for sustainable bioproduction
  preprints 2025 置信度 0.74
• Data-Driven Strain Design Towards Mitigating Biomanufacturing Stresses
  Abstract Microbial strains used in large-scale biomanufacturing of melatonin often experience stresses like reactive oxygen species (ROS), SOS response, and acid stress, which can reduce productivity. This study leveraged a data-driven workflow to identify mut…
  preprints PV Phaneuf, SH Kim, K Rychel, C Rode 等 2023 置信度 0.74
• Effect of Over-expression of GRXs on Thermo and Acetic Acid Stress Tolerance of <i>Saccharomyces cerevisiae</i>
  preprints 2024 置信度 0.74
• Prevention of ribozyme catalysis through cDNA synthesis enables accurate RT-qPCR measurements of context-dependent ribozyme activity
  preprints 2024 置信度 0.74
• Advances in serum-free media for CHO cells: From traditional serum substitutes to microbial-derived substances
  preprints 2024 置信度 0.74
• Adaptation of Aglycosylated Monoclonal Antibodies for Improved Production in Komagataella phaffii
  preprints 2024 置信度 0.74
• Comparative Approaches for Quantification of Product Yield in the Production of Recombinant Green Fluorescent Protein (GFPuv) Expressed in <i>E. coli</i>
  preprints 2024 置信度 0.74
• Low intensity mechanical signals promote proliferation in a cell-specific manner: Tailoring a non-drug strategy to enhance biomanufacturing yields
  preprints 2023 置信度 0.74
• Towards a Yersinia pestis lipid A recreated in an Escherichia coli scaffold genome
  preprints 2024 置信度 0.74
• AI-driven high-throughput droplet screening of cell-free gene expression
  preprints 2024 置信度 0.74
• Metabolic Engineering of Microbial Cell Factories For Sustainable Biomanufacturing
  Metabolic engineering is essential for the development of microbial cell factories to produce biomolecules from low-value renewable substrates. This role helps advance the development of ecologically responsible and commercially robust chemical industries, inc…
  preprints Azeemat Olanrewaju Olayiwola, Abubakar Dalhatu, Olutayo Micheal Oyewole, Grace Oluwasikemi Oke 等 2023 置信度 0.74
• regLM: Designing realistic regulatory DNA with autoregressive language models
  preprints 2024 置信度 0.74
• CuBe: a geminivirus-based copper-regulated expression system suitable for post-harvest activation
  preprints 2024 置信度 0.74
• Evaluating the feasibility of medium chain oleochemical synthesis using microbial chain elongation
  preprints 2024 置信度 0.74
• Removal of Empty Capsids from High-Dose Adeno-Associated Virus 9 Gene Therapies
  preprints 2024 置信度 0.74
• Metabolic engineering of yeast for <i>de novo</i> production of kratom monoterpene indole alkaloids
  preprints 2024 置信度 0.74
• Status and future developments for downstream processing of biological products Perspectives from the Recovery XIX yield roundtable discussions
  preprints 2024 置信度 0.74
• Bottlenecks in the Implementation of Genome Scale Metabolic Model Based Designs for Bioproduction from Aromatic Carbon Sources
  preprints 2024 置信度 0.74
• Pooled CRISPR interference screening identifies crucial transcription factors in gas-fermenting <i>Clostridium ljungdahlii</i>
  preprints 2024 置信度 0.74
• Construction of a reference genome for <i>Starmerella batistae</i> and annotation of <i>Starmerella</i> species reveal a close evolutionary relationship with <i>Schizosaccharomyces pombe</i> and suggest an alternative pathway for sophorolipid production.
  preprints 2025 置信度 0.74
• Revealing reaction intermediates in one-carbon elongation ThDP/CoA dependent enzyme family
  preprints 2024 置信度 0.74
• Trade-off Between Resistance and Persistence in High Cell Density <i>Escherichia Coli</i> Cultures
  preprints 2024 置信度 0.74
• Modeling N-linked Glycosylation: Advances and Challenges in Predicting Glycan Structures during Biomanufacturing
  N-linked glycosylation is a process in which glycans are added to the nitrogen atom of the asparagine amino acid of the protein. It has a significant impact on protein function, stability, and immunogenicity. Modelling N-glycosylation is a complex task due to …
  preprints Sumit K. Singh, Sahil Khan, Aryaman Joshi 2023 置信度 0.74
• MPEK: a multi-task learning based on pre-trained language model for predicting enzymatic reaction kinetic parameters
  preprints 2024 置信度 0.74
• Embedding biomimetic vascular networks via coaxial sacrificial writing into functional tissue
  preprints 2024 置信度 0.74
• High performance anion exchange chromatography purification of probiotic bacterial extracellular vesicles enhances purity and anti-inflammatory efficacy
  preprints 2023 置信度 0.74
• A modular toolkit for environmental <i>Rhodococcus, Gordonia</i> , and <i>Nocardia</i> enables complex metabolic manipulation
  preprints 2024 置信度 0.74
• Detecting Features of Protein Structure through their Mediator-Accessible Redox Activities
  preprints 2023 置信度 0.74
• Metabolic priming of GD2 <i>TRAC</i> -CAR T cells during manufacturing promotes memory phenotypes while enhancing persistence
  preprints 2024 置信度 0.74
• 3D Microcapsules for Human Bone Marrow Derived Mesenchymal Stem Cell Biomanufacturing in a Vertical-Wheel Bioreactor
  Abstract Microencapsulation of human mesenchymal stromal cells (MSCs) via electrospraying has been well documented in tissue engineering and regenerative medicine. Herein, we report the use of microencapsulation, via electrospraying, for MSC expansion using a …
  preprints Matthew Teryek, Pankaj Jadhav, Raphaela Bento, Biju Parekkadan 2023 置信度 0.74
• Protection of Biomanufacturing Processes from Virus Contamination through Upstream Virus Filtration of Cell Culture Media
  Medical progress as enabled by early plasma products has also revealed biological safety challenges. The combination of donor selection, donation testing and virus reduction processes has effectively addressed these concerns, and today medicinal plasma product…
  preprints Andreas Wieser, Jens Modrof, Thomas Kreil 2023 置信度 0.74
• Synergistic, shape-controlled endothelialized spheroid-hydrogel for wound healing.
  europepmc 2026 置信度 0.80
• Highly selective leaching of lithium via the synergistic effect of lactic acid and hydrogen peroxide.
  europepmc 2026 置信度 0.80
• New perspectives on serum-free cell culture: Harnessing microbial resources for innovative media development in food biomanufacturing.
  europepmc 2026 置信度 0.80
• Development and evaluation of a virus-like particle PEDV vaccine based on MS2 bacteriophage.
  europepmc 2026 置信度 0.80
• Mechanistic insights into selenium nanoparticles: Comparative effects in plant and animal systems.
  europepmc 2026 置信度 0.80
• Sulfate as a regulator of Bacteroides thetaiotaomicron glutamate decarboxylase: Elucidating the bipartite binding and regulation mechanism.
  europepmc 2026 置信度 0.80
• Electrospun nanofiber-based platforms for mycotoxins sensing: Recent advances and future directions.
  Mycotoxins, as toxic secondary metabolites produced by various fungi, represent widespread contaminants in global agricultural products, raw materials, and resulting food and feed supplies. Consequently, the necessity for their sensitive and rapid detection ha…
  pubmed Kumar V, Ruhal S, Kim KH, Vanish Kumar 等 2026 置信度 0.82
• Emerging AI plant microneedles for closed-loop monitoring and precision regulation.
  The lack of spatiotemporal precision in conventional physiological monitoring and agrochemical application hinders real-time plant intervention. Plant microneedles serve as a minimally invasive biointerface capable of fluid sampling, in situ sensing, and targe…
  europepmc 2026 置信度 0.80
• Influence of printing orientation on the manufacturing accuracy and functional properties of multi-material inkjet-printed complete dentures.
  europepmc 2026 置信度 0.80
• Fluorescent hydrogel kit based on photonic crystal-enhanced DNA-templated silver nanoclusters for miRNA detection.
  europepmc 2026 置信度 0.80
• Exogenous matrix-free biomanufacturing of glioblastoma organoids enables autonomous assembly of neurovascular-like structures and extracellular matrix.
  europepmc 2026 置信度 0.80
• Development of a chemometric platform for mid-infrared fermentation monitoring.
  europepmc 2026 置信度 0.80
• Degradation of Wheat Straw by &lt;i&gt;Streptomyces thermocarboxydus&lt;/i&gt; XH2: Insights from Genomic and Transcriptomic Analyses.
  europepmc 2026 置信度 0.80
• ApbZIP2-mediated enhancement of lipid productivity supports sustainable plant-based omega-3 biomanufacturing.
  europepmc 2026 置信度 0.80
• Recent Advances on Diol Bioproduction.
  europepmc 2026 置信度 0.80
• Process optimization and hybrid nanoflower synthesis of 5- hydroxymethylfurfural oxidase for efficient oxidation of HMF and its derivatives to 2,5- furandicarboxylic acid.
  europepmc 2026 置信度 0.80
• Toward a 4D genome annotation of CHO cells for biomanufacturing.
  europepmc Pablo Di Giusto, Jasmine Tat, Nathan E. Lewis 2026 置信度 0.80
• Biomanufacturing and Scale-Up: Pathways to Biochemicals, Biofuels, and Biomaterials.
  europepmc Carolina A. Barcelos, Pavel Dvořák, Charles J. Foster, Juan Nogales 等 2026 置信度 0.80
• Human cardiac organoids: multidimensional integration and clinical translation potential.
  europepmc 2026 置信度 0.80
• Discovery of a thermostable eugenol oxidase for vanillin biosynthesis from vanillyl alcohol via resting whole-cell catalysis.
  europepmc 2026 置信度 0.80
• Rational design of high-productivity perfusion processes for CHO Cells: From growth inhibitory strategies to model-driven optimization.
  europepmc 2026 置信度 0.80
• Bio-inspired laminar flow control enables the fabrication of highly aligned graphene nanocomposites with enhanced mechanical and tribological performance through high-precision digital light processing.
  europepmc 2026 置信度 0.80
• Modulation of mycelial formation in Streptomyces toxytricini and enhancement of lipstatin using light.
  europepmc 2026 置信度 0.80
• A multi-dimensional engineering strategy integrating computational design, self-cyclization and whole cell biocatalysis for efficient epilactose production.
  europepmc 2026 置信度 0.80
• Aqueous phase reforming of biomass-derived acids over a highly dispersed platinum catalyst.
  europepmc 2026 置信度 0.80
• QMAP: a benchmark for standardized evaluation of antimicrobial peptide MIC and hemolytic activity regression.
  europepmc 2026 置信度 0.80
• A Label-free Simple Biosensor for Pb&lt;sup&gt;2+&lt;/sup&gt; Detection Based on G-quadruplex DNA and Exonuclease III.
  europepmc 2026 置信度 0.80
• Understanding Osmolality as a Critical Process Parameter in Mammalian Muscle Cell Culture and Biomanufacturing.
  Abstract Osmolality is a critical yet frequently underrecognized physicochemical parameter in mammalian cell culture systems and remains insufficiently treated as a formal process control variable in bioprocess engineering. To establish its importance comprehe…
  europepmc Mirinal K. Rayappa 2026 置信度 0.80
• Innovating biomanufacturing with coculture-based engineered living materials.
  europepmc Runze Pan, Shufan Zhao, Yujia Jiang, Min Jiang 等 2026 置信度 0.80
• Toolbox for Bio Safety Manufacturing Waste Treatment.
  europepmc 2026 置信度 0.80
• Multi omics reveals mesodermal fate bias and enables predictive cell state control in human pluripotent stem cell biomanufacturing
  Abstract Despite accelerating interest in using human induced pluripotent stem cell (hiPSC)–derived products for disease modeling and therapeutic development, there is substantial evidence that conventional culture approaches do not fully recapitulate natural …
  europepmc James Colter, Tiffany Dang, Daniel Young, Antoine Dufour 等 2026 置信度 0.80
• Online characterization of surrogate metrics for metabolic phenotype in human induced pluripotent stem cell bioprocessing
  europepmc 2026 置信度 0.80
• Process-Integrated Matrix Engineering and Drying Strategy for Stabilization of Fibrinolytic Protease from Bacillus tequilensis toward Biomanufacturing Applications
  Abstract Stabilizing enzyme functionality during downstream processing remains a central challenge in scalable biomanufacturing. This study presents a process-integrated evaluation of microencapsulation strategies to preserve the activity of a fibrinolytic pro…
  europepmc Stalis Norma Ethica, Muhammad Ziddan Bayu Aji, Irfanul Chakim, Ocky Karna Radjasa 等 2026 置信度 0.80
• ZAT-DNA enables DNA data storage with molecular-layer non-replicability.
  Deoxyribonucleic acid provides unmatched information density and longevity for data storage, yet its easy amplification by polymerase chain reaction enables unauthorized replication at negligible cost. We introduce ZAT-DNA, which encodes information in pattern…
  europepmc 2026 置信度 0.80
• [Advances in genome editing technologies in &lt;i&gt;Komagataella phaffii&lt;/i&gt; and their applications in biomanufacturing].
  Komagataella phaffii is widely recognized as a premier host for the production of recombinant proteins and value-added metabolites, owing to its low background secretion of endogenous proteins, strong capacity for heterologous protein secretion, and robust gro…
  pubmed Han C, Li Y, Zhang H 2026 置信度 0.82
• Focal ischemic stroke impairs REM sleep and inhibits c-Fos expression of SST neuron in EP of male rats.
  europepmc 2026 置信度 0.80
• From design-build-test-learn cycles to AI-driven digital twins for bioprocess scale-up in the Genesis Mission era.
  europepmc 2026 置信度 0.80
• Pseudo Perfusion of Chinese Hamster Ovary (CHO) Cells as a Reliable Platform for Data Generation to Model and Guide Continuous Perfusion Biomanufacturing.
  ABSTRACT Chinese Hamster Ovary (CHO) cell monoclonal antibody (mAb) production in continuous perfusion has witnessed a renewed interest within the biopharmaceutical industry. Widespread implementation of perfusion biomanufacturing, however, remains hindered by…
  europepmc Nikola G. Malinov, Shivam Barodiya, Marianthi G. Ierapetritou, Eleftherios T. Papoutsakis 2026 置信度 0.80
• Characterization and discrimination of volatile organic compounds in quinoa-adjunct beer brewed with 6 differently colored quinoa varieties by GC-MS combining GC-E-nose and GC-IMS.
  europepmc 2026 置信度 0.80
• Engineering the future of advanced therapy medicinal products: a bioengineering call to action.
  Advanced Therapy Medicinal Products - cell therapies, gene therapies, and tissue-engineered products - are beginning to deliver on the promise of curative medicine: CAR-T therapies double survival in chemotherapy-refractory lymphomas, gene therapies reverse th…
  pubmed Nieri G, Spiller A, Federico S, Aiuti A 等 2026 置信度 0.82
• [Development of a postgraduate course Computational Biology for cultivating talents in biomanufacturing].
  europepmc 2026 置信度 0.80
• Expression and immunoassay assessment of immunomodulatory PanDR and SARS-CoV-2 receptor-binding domain antigen in bacteria host cell.
  europepmc 2026 置信度 0.80