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Continuous biomanufacturing is gaining significant attention in biopharmaceutical production, offering enhanced productivity, scalability, and process consistency compared with conventional batch and fed-batch operations. Regulatory initiatives, including the …
pubmed
Kim D, Park S, Lee C, Park CH 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Achieving more sustainable production in emerging biomanufacturing sectors depends not only on technological innovation but also on how production systems are organized, governed, and scaled. Fermentation-derived proteins produced through biomass and precision…
europepmc
Germano Glufke Reis, Antonella Samoggia, Maria Clara Manzoki
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Biomanufacturing advances sustainable production and circular economy, while wastes-derived one-carbon (C1) compounds (e.g., CO 2 , methanol, formate and methane) expand substrate diversity, accelerate wastes valorization, and mitigate climate change. The desi…
pubmed
Li Y, Xu G, Zheng Y, Liu M 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Gas sensing plays a critical role across diverse fields, including medical diagnostics, industrial safety, and environmental monitoring. However, conventional gas sensors often suffer from poor selectivity and limited sensitivity, especially at low concentrati…
pubmed
Xia X, Yuan H, Wang B, Cheng Y 等
2026
置信度 0.82
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Osteoporosis management remains challenging, partly due to the poor bioavailability of drugs in bone and the systemic side effects of current treatments. To address this, we engineered a targeted nanomedicine therapy using a DNA aptamer that specifically binds…
pubmed
Yang Y, Wan Z, Guo X, Yang Z 等
2026
置信度 0.82
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The economic viability of methanol-based biomanufacturing, particularly with green methanol as feedstock, is often limited by the low value of single-product processes. Here, we developed an integrated co-production strategy in the methylotrophic yeast Pichia …
pubmed
Fang J, Wang S, Liu G, Zhang Y 等
2026
置信度 0.82
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Abstract Space-based biomanufacturing has historically focused on long-duration crewed and exploration missions, but its greater potential lies in supporting in-space logistics, manufacturing, and servicing in Earth orbit. This article provides a strategic per…
europepmc
Andrew KD Younger
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Microbial cell factories are central platforms for sustainable industrial biomanufacturing, yet inefficient transmembrane transport continues to hinder their large-scale industrial translation. Transporter engineering has progressed from trial-and-error overex…
pubmed
Cheng Y, Xie X, Guo L, Ji H 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder characterized by insulin resistance, dyslipidemia and inflammation. Although probiotics have shown potential in improving glycemic control in T2DM, the systemic mechanisms underlying their …
pubmed
Zhang J, Li R, Zhu L, Alvi AD 等
2026
置信度 0.82
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Myeloid leukemia (ML) remains a therapeutic challenge due to the frequent development of resistance to frontline cytosine arabinoside (AraC). One of a key driver of this resistance is the overexpression of cytidine deaminase (CDA), which inactivates AraC. Here…
europepmc
2026
置信度 0.80
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In line with worldwide initiatives to achieve carbon neutrality and biomass valorization, the present study offers a sustainable bioprocess for xylitol recovery from rice straw hydrolysate (RSH). The process of xylitol recovery and ultrasound-assisted hybrid c…
pubmed
Singh S, Arya SK, Krishania M
2026
置信度 0.82
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DNA offers exceptional information density and long-term stability, yet its practical deployment is limited by destructive readout and the absence of a reusable, physically addressable architecture that connects nanoscale molecular information with macroscale …
europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Methanol is an ideal feedstock for biomanufacturing and can be produced in large quantities from carbon dioxide via photocatalysis or electrolytic reduction, contributing to global carbon neutrality. In this study, we described an engineered Pichia pastoris st…
pubmed
Zhao C, Wang T, Liu H, Li Y 等
2026
置信度 0.82
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DescriptionProgrammable Bio-Interface Tissue (PBIT): Actualizing the Vision at Its Highest Possible FidelityThis work presents a forward-looking scientific framework for Programmable Bio-Interface Tissue (PBIT)—a next-generation adaptive biomaterial platform e…
datacite
NHUT, NHUT
2026
置信度 0.66
MSD MANUALFDANASA
-
DescriptionProgrammable Bio-Interface Tissue (PBIT): Actualizing the Vision at Its Highest Possible FidelityThis work presents a forward-looking scientific framework for Programmable Bio-Interface Tissue (PBIT)—a next-generation adaptive biomaterial platform e…
datacite
NHUT, NHUT
2026
置信度 0.66
MSD MANUALFDANASA
-
This document systematically elaborates on the ABF-Mars Pioneer closed-loop biomanufacturing system for extreme Martian environments. Based on the overall system architecture and 12-month MVP phased development roadmap, it details the internal and external mec…
datacite
廖, 宝文
2026
置信度 0.66
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This document systematically elaborates on the ABF-Mars Pioneer closed-loop biomanufacturing system for extreme Martian environments. Based on the overall system architecture and 12-month MVP phased development roadmap, it details the internal and external mec…
datacite
廖, 宝文
2026
置信度 0.66
-
Abstract This upgraded edition (v1.7) of the white paper presents the biogenic replicator, a desktop and implantable molecular compiler that converts digital sequence files directly into therapeutic biologics without fermentation or cold chain. A “Plain‑Langua…
datacite
Ledgister, Robert
2026
置信度 0.66
-
Abstract This upgraded edition (v1.7) of the white paper presents the biogenic replicator, a desktop and implantable molecular compiler that converts digital sequence files directly into therapeutic biologics without fermentation or cold chain. A “Plain‑Langua…
datacite
Ledgister, Robert
2026
置信度 0.66
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Ill., graph. Darst.
datacite
Unknown
2012
置信度 0.66
AckerschmalwandDarmkrebsDiätetikGlucosinolateErnährungsphysiologie
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This repository contains the source code and numerical results for the paper "Integrating upstream and downstream planning to increase biomanufacturing profitability" on August 5th 2026.
datacite
MirkoTUM
2026
置信度 0.66
-
Biological and pharmaceutical systems operate under extreme safety, regulatory, and precision constraints — involving complex multi-stage processes from genomic analysis to biologics manufacturing, from sterile processing to cold-chain distribution. Yet today,…
datacite
Andrews, Ronald Jason
2026
置信度 0.66
DAIGSdeterministic governancebiotechnologypharmaceutical manufacturingbiologics
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Biological and pharmaceutical systems operate under extreme safety, regulatory, and precision constraints — involving complex multi‑stage processes from genomic analysis to biologics manufacturing, from sterile processing to cold‑chain distribution. Yet today,…
datacite
Andrews, Ronald Jason
2026
置信度 0.66
DAIGSdeterministic governancebiotechnologypharmaceutical manufacturingbiologics
-
This repository contains the source code and numerical results for the paper "Integrating upstream and downstream planning to increase biomanufacturing profitability" handed in in August 2026.
datacite
MirkoTUM
2026
置信度 0.66
-
This repository contains the source code and numerical results for the paper "Integrating upstream and downstream planning to increase biomanufacturing profitability" on August 5th 2026.
datacite
MirkoTUM
2026
置信度 0.66
-
Abstract:The biopharmaceutical sector is at present undergoing a critical shift from empirical, batch manufacturing to data-driven "Bioprocessing 4.0." This study examines the economic impact of the integration of Artificial Intelligence (AI) and Machine Learn…
datacite
Sagalgile R. M, Nikume P. M., Wankhede T. A., Magare K. P. 等
2026
置信度 0.66
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Abstract:The biopharmaceutical sector is at present undergoing a critical shift from empirical, batch manufacturing to data-driven "Bioprocessing 4.0." This study examines the economic impact of the integration of Artificial Intelligence (AI) and Machine Learn…
datacite
Sagalgile R. M, Nikume P. M., Wankhede T. A., Magare K. P. 等
2026
置信度 0.66
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Protocol for a scoping review examining the current state of mRNA vaccine manufacturing localization in sub-Saharan Africa, guided by the JBI methodology and PRISMA-ScR reporting standards. Registered prior to title/abstract screening.
datacite
MOSES KALAMUZI
2026
置信度 0.66
Medicine and Health SciencesmRNA vaccine vaccine manufacturing sub-Saharan Africa technology transfer scoping review vaccine equity biomanufacturing
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Description (Abstract) This upgraded edition (v1.6) of the white paper presents the biogenic replicator, a desktop and implantable molecular compiler that converts digital sequence files directly into therapeutic biologics without fermentation or cold chain. A…
datacite
Ledgister, Robert
2026
置信度 0.66
-
BioSynthPro is a conceptual and engineering framework for circular multispecies biomanufacturing. The project explores the integration of photosynthetic, heterotrophic, mycogenic, and probiotic biological domains into a coordinated resource-recycling ecosystem…
datacite
Dinev, Ivan Vasilev
2026
置信度 0.66
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BioSynthPro is a conceptual and engineering framework for circular multispecies biomanufacturing. The project explores the integration of photosynthetic, heterotrophic, mycogenic, and probiotic biological domains into a coordinated resource-recycling ecosystem…
datacite
Dinev, Ivan Vasilev
2026
置信度 0.66
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Artificial intelligence has become a transformative tool in bioprocessing through predictive modeling and adaptive control. Traditionally, bioprocessing relied on experimentation and static control mechanisms, limiting flexibility and reproducibility, thereby …
datacite
Sai Surya Raja Amogha Tenneti
2026
置信度 0.66
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Artificial intelligence has become a transformative tool in bioprocessing through predictive modeling and adaptive control. Traditionally, bioprocessing relied on experimentation and static control mechanisms, limiting flexibility and reproducibility, thereby …
datacite
Sai Surya Raja Amogha Tenneti
2026
置信度 0.66
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This preprint explores the theoretical framework and engineering requirements for planetary sky farming within the temperate atmospheric layers of Venus. While the surface of Venus is hostile to known biology, the atmospheric layer at an altitude of fifty kilo…
datacite
Hallelujah, Paul
2026
置信度 0.66
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This preprint explores the theoretical framework and engineering requirements for planetary sky farming within the temperate atmospheric layers of Venus. While the surface of Venus is hostile to known biology, the atmospheric layer at an altitude of fifty kilo…
datacite
Hallelujah, Paul
2026
置信度 0.66
-
The Organic Revolution in 2026 presents a framework for transitioning from an extractive industrial economy to a regenerative, circular system. The paper argues that current climate and resource crises are structural failures of an economy that treats the Eart…
datacite
Marie-Soleil Seshat Landry
2026
置信度 0.66
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The Organic Revolution in 2026 presents a framework for transitioning from an extractive industrial economy to a regenerative, circular system. The paper argues that current climate and resource crises are structural failures of an economy that treats the Eart…
datacite
Marie-Soleil Seshat Landry
2026
置信度 0.66
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Empirical, a groundbreaking computational tool designed to identify proteins by analyzing their atomic stoichiometry rather than relying on traditional genetic sequence alignment. By converting nucleotide sequences into precise chemical formulas—counting speci…
datacite
Umair Masood Awan
2026
置信度 0.66
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Empirical, a groundbreaking computational tool designed to identify proteins by analyzing their atomic stoichiometry rather than relying on traditional genetic sequence alignment. By converting nucleotide sequences into precise chemical formulas—counting speci…
datacite
Umair Masood Awan
2026
置信度 0.66
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Project 46554 funded ($200000) by the Canada Foundation for Innovation (John R. Evans Leaders Fund) / Projet 46554 financé (200000 $) par la Fondation canadienne pour l'innovation (Fonds des leaders John-R.-Evans)
datacite
Canada Foundation for Innovation | Fondation canadienne pour l'innovation
2025
置信度 0.66
-
The Midterm Public Seminar was implemented through participation in two separate events and presenting the project to the pubic audience.The first BioProS Public Seminar was held during 6th CIRP Conference on Biomanufacturing on 11-12 June 2024 in Dresden, Ger…
datacite
Fraunhofer Institute for Manufacturing Engineering and Automation, University of Tübingen, Politecnico di Milano
2026
置信度 0.66
BioPros
-
The Midterm Public Seminar was implemented through participation in two separate events and presenting the project to the pubic audience.The first BioProS Public Seminar was held during 6th CIRP Conference on Biomanufacturing on 11-12 June 2024 in Dresden, Ger…
datacite
Fraunhofer Institute for Manufacturing Engineering and Automation, University of Tübingen, Politecnico di Milano
2026
置信度 0.66
BioPros
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This comprehensive guide explores the Design-Build-Test-Learn (DBTL) cycle, the cornerstone framework for modern metabolic engineering and synthetic biology. The DBTL cycle enables the systematic development of microbial cell factories for the sustainable prod…
datacite
metabolic engineering science
2026
置信度 0.66
DBTL cyclemetabolic engineeringsynthetic biologymachine learningbiofoundries
-
This comprehensive guide explores the Design-Build-Test-Learn (DBTL) cycle, the cornerstone framework for modern metabolic engineering and synthetic biology. The DBTL cycle enables the systematic development of microbial cell factories for the sustainable prod…
datacite
metabolic engineering science
2026
置信度 0.66
DBTL cyclemetabolic engineeringsynthetic biologymachine learningbiofoundries
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HEK293 is the primary human platform for gene-therapy vector and recombinant-protein manufacturing, yet it lacks the curated, predictive genome-scale metabolic model that cancer lines already have. We present such a model, built on Human-GEM (12,931 reactions,…
datacite
Mule, Sushil
2026
置信度 0.66
HEK293genome-scale metabolic modelflux balance analysisHuman-GEMconstraint-based modelling
-
HEK293 is the primary human platform for gene-therapy vector and recombinant-protein manufacturing, yet it lacks the curated, predictive genome-scale metabolic model that cancer lines already have. We present such a model, built on Human-GEM (12,931 reactions,…
datacite
Mule, Sushil
2026
置信度 0.66
HEK293genome-scale metabolic modelflux balance analysisHuman-GEMconstraint-based modelling
-
This extensive review synthesizes current research on the integration of plants into Bioregenerative Life Support Systems (BLSS), a critical technology for sustaining human life during long-duration space missions. Plants in BLSS serve multiple indispensable f…
datacite
plant science technology
2026
置信度 0.66
Bioregenerative Life Support Systemsmicrogravityspace radiationgravitropismmolecular pharming
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This extensive review synthesizes current research on the integration of plants into Bioregenerative Life Support Systems (BLSS), a critical technology for sustaining human life during long-duration space missions. Plants in BLSS serve multiple indispensable f…
datacite
plant science technology
2026
置信度 0.66
Bioregenerative Life Support Systemsmicrogravityspace radiationgravitropismmolecular pharming
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The proposed H–E–S–M (Hormonal induction, Environmental stabilization, State transition, Micronutrient gating) governance model defines a cross-domain regenerative control architecture spanning plant tissue culture, somatic embryogenesis, organogenesis, marine…
datacite
Harrison, Kyle, Harrison, Kyle
2026
置信度 0.66
Guided Tissue Regeneration, Periodontal/classificationComparative Repair BiologyEndoplasmic Reticulum Chaperone BiP/biosynthesisTranslational Science, BiomedicalTechnology Assessment, Biomedical/classification
-
The proposed H–E–S–M (Hormonal induction, Environmental stabilization, State transition, Micronutrient gating) governance model defines a cross-domain regenerative control architecture spanning plant tissue culture, somatic embryogenesis, organogenesis, marine…
datacite
Harrison, Kyle, Harrison, Kyle
2026
置信度 0.66
Guided Tissue Regeneration, Periodontal/classificationComparative Repair BiologyEndoplasmic Reticulum Chaperone BiP/biosynthesisTranslational Science, BiomedicalTechnology Assessment, Biomedical/classification
-
The repository includes a README file, dependency file, random seeds, example datasets, and scripts to reproduce all reported capacity, sequence-constraint, error-modeling, benchmarking, and cost-model analyses.
datacite
Tastan, Cihan, Aydin, Beyza
2026
置信度 0.66
-
The repository includes a README file, dependency file, random seeds, example datasets, and scripts to reproduce all reported capacity, sequence-constraint, error-modeling, benchmarking, and cost-model analyses.
datacite
Tastan, Cihan, Aydin, Beyza
2026
置信度 0.66
-
1. Abstract Title: Architectural Informational Persistence: The Capacity-Complexity Theorem and Topological Cosmic Operators (TCOs) Abstract: Traditional informational storage paradigms, which treat matter as a passive repository, are fundamentally limited by …
datacite
Kasiulevicius, Egidijus, Kasiulevicius, AZUOLAS, Kasiuleviciute, Saule, Kasiuleviciene, Ausra
2026
置信度 0.66
-
1. Abstract Title: Architectural Informational Persistence: The Capacity-Complexity Theorem and Topological Cosmic Operators (TCOs) Abstract: Traditional informational storage paradigms, which treat matter as a passive repository, are fundamentally limited by …
datacite
Kasiulevicius, Egidijus, Kasiulevicius, AZUOLAS, Kasiuleviciute, Saule, Kasiuleviciene, Ausra
2026
置信度 0.66
-
datacite
Schutzbach, Maximilian
2026
置信度 0.66
-
A growing trend in biopharmaceutical industry involving the continuous cell perfusion process requires an efficient and reliable cell retention scheme. The current filtration systems suffer from the issue of membrane clogging, limiting the efficiency and produ…
datacite
Syed, MS, Marquis, CM, Taylor, RT, Ebrahimi Warkiani, MEW
2018
置信度 0.66
-
This paper presents NeuroGenetics, a conceptually designed AI-integrated autonomous platform for the end-to-end production, personalization, and in-vivo guidance of engineered immune cells targeting hematological malignancies, with a primary proof-of-concept f…
datacite
Heikal, Yousef
2026
置信度 0.66
CAR-T cell therapy; Acoustogenetics; Organ-on-a-Chip; Cell manufacturing automation; AI-driven bioprocessing; Federated machine learning; Wearable biosensor; Leukemia immunotherapy; Digital twin bioprocessing; CRISPR-dCas9.
-
This paper presents NeuroGenetics, a conceptually designed AI-integrated autonomous platform for the end-to-end production, personalization, and in-vivo guidance of engineered immune cells targeting hematological malignancies, with a primary proof-of-concept f…
datacite
Heikal, Yousef
2026
置信度 0.66
CAR-T cell therapy; Acoustogenetics; Organ-on-a-Chip; Cell manufacturing automation; AI-driven bioprocessing; Federated machine learning; Wearable biosensor; Leukemia immunotherapy; Digital twin bioprocessing; CRISPR-dCas9.
-
Biomanufacturing advances sustainable production and circular economy, while wastes-derived one-carbon (C1) compounds (e.g., CO 2 , methanol, formate and methane) expand substrate diversity, accelerate wastes valorization, and mitigate climate change. The desi…
datacite
Yang Li, Guiping Xu, Yujia Zheng, Mingxiong Liu 等
2026
置信度 0.66
Space SciencePharmacologyEcologyBiological Sciences not elsewhere classified
-
Biomanufacturing advances sustainable production and circular economy, while wastes-derived one-carbon (C1) compounds (e.g., CO 2 , methanol, formate and methane) expand substrate diversity, accelerate wastes valorization, and mitigate climate change. The desi…
datacite
Yang Li, Guiping Xu, Yujia Zheng, Mingxiong Liu 等
2026
置信度 0.66
Space SciencePharmacologyEcologyBiological Sciences not elsewhere classified
-
Frontiers in Biotechnology and Bioinnovation: From Research to Real-World Applications explores the remarkable progress of biotechnology as a driving force for scientific innovation and sustainable development. The rapid advancement of molecular biology, synth…
datacite
Ruban P, C. Ravinder Singh, T. Govindan, T.Aravindhan
2026
置信度 0.66
-
Frontiers in Biotechnology and Bioinnovation: From Research to Real-World Applications explores the remarkable progress of biotechnology as a driving force for scientific innovation and sustainable development. The rapid advancement of molecular biology, synth…
datacite
Ruban P, C. Ravinder Singh, T. Govindan, T.Aravindhan
2026
置信度 0.66
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crossref
2014-03-28T02:47:38Z
置信度 0.70
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crossref
Babetta L Marrone
2020-04-28T04:46:23Z
置信度 0.70
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置信度 0.70
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Seohyoung Kim, Congqiang Zhang
2026-07-29T07:16:59Z
置信度 0.70
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On the wave of more and more manufacturers embracing the pervasive mission to build digital twins, also biopharmaceutical industry envisions a significant paradigm shift of digitalisation towards an intelligent factory where bioprocesses continuously learn fro…
crossref
Elisa Canzani, Sander W. Timmer
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置信度 0.70
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There is a question I keep returning to — one that sits underneath the policy debates, the appropriations fights, the executive orders, and the increasingly urgent memos circulating through the national security establishment: Can America actually <em> m…
crossref
Alexander Titus
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Hansen Tjo
2026-08-26T12:00:19Z
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crossref
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Synthetic biology, an emerging research field, can promote biomanufacturing by offering various efficient chassis. Engineering Bacillus subtilis, an important workhorse in industrial biotechnology, through synthetic biology approaches may be a disruptive innov…
preprints
Wenbo Zhang, Xinshu Zhu, Yan Wang, Tao Li
2021
置信度 0.74
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