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• Compact Oligomerized-Motif Promoters for Adjustable Control of Transcription (COMPACT) for Robust, Tunable and Bidirectional Gene Expression in Mammalian Cells
  preprints 2026 置信度 0.74
• Gas uptake stoichiometry governs carbon partitioning in syngas-fermenting <i>Clostridium autoethanogenum</i>
  preprints 2026 置信度 0.74
• Machine Learning-Enabled Raman Spectroscopy for Process Analytical Technology and Real-Time Release Testing in Bioprocess Manufacturing: A Comparative Predictive Modeling Study
  preprints 2026 置信度 0.74
• Organoid research in diabetes and cardiovascular diseases: bibliometric mapping of knowledge evolution and emerging frontiers in organ-on-a-chip systems, bioprinting, artificial intelligence, and multi-omics
  europepmc 2026 置信度 0.80
• MCBO: Mammalian Cell Bioprocessing Ontology, A Hub-and-Spoke, IOF-Anchored Application Ontology
  preprints 2026 置信度 0.74
• Seven mutations unlock strict synthetic methylotrophy in engineered <i>Pseudomonas putida</i>
  preprints 2026 置信度 0.74
• Xeno-Free Peptide-Functionalized Hydrogels Support hiPSC Encapsulation and <i>In Situ</i> Differentiation into Structurally Mature Cardiomyocytes
  While defined synthetic substrates can replace Matrigel for human induced pluripotent stem cell (hiPSC) culture and hiPSC-derived cardiomyocyte (hiPSC-CM) production, existing approaches culture cells on two-dimensional surfaces and yield structurally immature…
  pubmed Hashemi M, Devi ND, Kooh YKG, Chen C 等 2026 置信度 0.82
• Volumetric Flow Imaging Microscopy to Enhance Particle Characterization
  preprints 2026 置信度 0.74
• Engineering Orthogonal Carbon Dissimilation: A Gluconate Bypass Platform for Robust Stationary-Phase Biomanufacturing
  Abstract Two-stage bioprocesses which decouple cell growth from product synthesis are an attractive approach to biomanufacturing. However high levels of production in stationary phase cultures often suffer from a progressive decline in metabolism. We demonstra…
  europepmc Utsuki Yano, Payel Sarkar, Michael D. Lynch 2025 置信度 0.80
• A continuous viral vaccine biomanufacturing platform utilizing multiple bioreactor configurations
  Abstract Scalable, continuous biomanufacturing processes have grown in importance to meet demand for smaller bioreactor sizes, lowered production costs, and improved quality attributes. The Sf9/recombinant baculovirus (rBV) expression system demonstrates promi…
  preprints Justin Sargunas, Bradley Priem, Dylan Carman, Taravat Sarvari 等 2026 置信度 0.74
• Cost-Effective Purification of Endotoxin-Free LIF, IL-2, and IL-33
  preprints 2026 置信度 0.74
• Serum-free media development and validation for cultivation of C2C12 immortalised murine myosatellite cell line for cultivated meat
  preprints 2026 置信度 0.74
• Computational reconstruction of Tyrannosaurus rex collagen for biomanufacturing of paleo-inspired biomaterials with tuneable stiffness
  Abstract Ancient protein fragments preserved in fossilized tissues offer evolutionary sequence information inaccessible through conventional genomics. Here we demonstrate computational reconstruction of full-length Tyrannosaurus rex type I collagen (COL1A1) by…
  europepmc T Mitchell, E Wolvetang 2025 置信度 0.80
• Large-Scale Synthesis of Bioengineered Heparin via Sequential Whole Cell Biocatalysis
  preprints 2026 置信度 0.74
• Comparing Kinetic versus Stoichiometric Priorities in Hybrid Models of CHO Metabolism
  Abstract Understanding Chinese hamster ovary (CHO) cell metabolism through mathematical models is essential for optimizing culture media and biomanufacturing processes. Current mechanistic models rely primarily on either flux balance analysis (FBA), estimating…
  europepmc Pratik Khare, Nelson Ndahiro, Stephanie Klaubert, Edward Ma 等 2025 置信度 0.80
• Streamlined stable CHO cell line development using droplet microfluidics with monoclonality assurance
  preprints 2026 置信度 0.74
• Tailoring Precise Genomic Integration Toward Isolate-to-Industry Strain Development for Scalable High-Titer Production of Polyhydroxyalkanoate
  preprints 2026 置信度 0.74
• Evaluation of acetic acid as a next-generation feedstock for lipid biomanufacturing in Rhodosporidium toruloides
  europepmc Jeffrey Li, Patrick Harrigan, Paul Pedevillano, Myat Lin 等 2025 置信度 0.80
• Systematic Evaluation of Signal Peptide-Driven Protein Secretion in the Fast-Growing Cyanobacterium <i>Synechococcus</i> sp. PCC 11901
  preprints 2026 置信度 0.74
• Late-Stage Large Extracellular Vesicles Reprogram CHO Cell Metabolism in a Glutamine-Dependent Mode and Promote Antibody-Productivity to Cell-Growth Tradeoff
  preprints 2026 置信度 0.74
• AI-Enhanced Digital Twins as Decision-Support Layers for Precision Management of Microbial Communication: The Case of Cocoa Pulp Juice Fermentation
  preprints 2026 置信度 0.74
• A Quantitative Approach to Optimise Microcarrier Surface Area for Smarter Adherent Cell Culture
  preprints 2026 置信度 0.74
• Metabolic Modification of Escherichia coli BL21 (DE3) to Produce Shinorine
  preprints 2026 置信度 0.74
• Engineering xylose metabolism for diverse polyhydroxyalkanoates synthesis in <i>Halomonas</i> TD
  preprints 2026 置信度 0.74
• Reprogramming fucose metabolism in Kosakonia sp. CCTCC M2018092 for glucose-driven fucosylated human milk oligosaccharide biosynthesis
  preprints 2026 置信度 0.74
• Carbon-negative biosynthesis of pyrone and pyridine dicarboxylic acids from terephthalic acid via continuous mixotrophic gas fermentation in <i>Cupriavidus necator</i> H16
  preprints 2026 置信度 0.74
• Automated Cell-free Protein Synthesis for Distributed Biomanufacturing
  europepmc 2025 置信度 0.80
• Phototropin modulates biosynthetic gene clusters network mediated biomanufacturing of anti-inflammatory metabolites in green lineage simply by illumination
  europepmc 2025 置信度 0.80
• Engineering a Temperature-Programmable Biosensor Toolkit for Recombinant Protein Production in Corynebacterium glutamicum
  preprints 2026 置信度 0.74
• Real-Time Prediction System for Biological Fermentation Parameters Based on an AI Electronic Nose: Universal Software and Hardware Architecture and Verification
  preprints 2026 置信度 0.74
• Microbial Production of γ-Curcumene in Metabolically Engineered Escherichia coli Using a Novel γ-Curcumene Synthase from Parthenium argentatum
  preprints 2026 置信度 0.74
• Building COVID-19 Vaccine Manufacturing Capacity in Nigeria: A Qualitative Needs Assessment of Barriers and Resource Requirements
  preprints 2026 置信度 0.74
• Genetic engineering of carbon monoxide dehydrogenases produces distinct autotrophic phenotypes in <i>Clostridium autoethanogenum</i>
  preprints 2026 置信度 0.74
• Increasing CHO cell harvest efficiency with cyclical cake filtration
  preprints 2026 置信度 0.74
• Enhanced Bioproduction and Processing of Mandelic Acid Enantiomers: Towards a Sustainable Platform for High-value Pharmaceutical and Polymer Applications
  europepmc 2025 置信度 0.80
• N terminal wobble base usage determines ribosome loading and thus protein expression fate
  preprints 2026 置信度 0.74
• International Multi-site Implementation of Local Cell-Free Protein Biomanufacturing to Advance Health and Research Equity
  europepmc 2025 置信度 0.80
• Integrated Multi-analytical Framework for Comprehensive Characterization of Lignocellulosic Hydrolysates
  europepmc 2025 置信度 0.80
• Metabolic diversity of microorganisms toward atypical sugar enantiomers
  preprints 2026 置信度 0.74
• Metabolic Engineering of Bacillus subtilis for High-Yield Surfactin Production
  europepmc 2026 置信度 0.80
• Tailored Cell Cycle Modulation Enhances AAV Manufacturing: Balancing Arrest with Adaptive Stress Responses
  preprints 2026 置信度 0.74
• A Statistically Rigorous Multi-Scale Texture Analysis Framework for 3D Spheroid Characterization: Temporal Autocorrelation Correction and Molecular Validation
  preprints 2026 置信度 0.74
• Multiobjective design of growth media with genome-scale metabolic models and Bayesian optimization
  europepmc 2025 置信度 0.80
• Pooled single-cell CRISPRa/i screens for functional genomics in bacteria at scale
  europepmc 2025 置信度 0.80
• Medicinal Plants in the Space Exploration Era: Challenges and Perspectives
  europepmc 2025 置信度 0.80
• Programmable cell differentiation in budding yeast uncouples reproductive and metabolic tasks
  europepmc 2025 置信度 0.80
• Integrated Omics Reveal the Core Regulatory Network Driving High-Level DHA Production in Aurantiochytrium sp. YHPM1
  preprints 2026 置信度 0.74
• Comparative genomic assessment of the Cupriavidus necator species for one-carbon based biomanufacturing
  The transition from a petroleum-based manufacturing to biomanufacturing is an important step towards a sustainable bio-economy. In particular biotechnological processes which use one carbon (C1) compounds as feedstock represent an interesting avenue. Many bact…
  preprints Magnus G Jespersen, Emil F Vangsgaard, Mariana Arango Saavedra, Stefano Donati 等 2025 置信度 0.74
• A dynamic metabolic flux analysis (DMFA) model for performance predictions of diverse CHO cell culture process modes and conditions
  preprints 2026 置信度 0.74
• Novel algal modular LOV domain proteins expand opto-biotechnological avenues for controlling of eukaryotic riboswitching, translational and proteolytic processes
  preprints 2025 置信度 0.74
• Supporting the implementation of chemometrics models in bioprocess from development to commercial stage
  preprints 2025 置信度 0.74
• Cupriavidus necator as flexible platform organism for trehalose production
  preprints 2025 置信度 0.74
• Large mRNA language foundation modeling with NUWA for unified sequence perception and generation
  preprints 2025 置信度 0.74
• Multi-strain Analysis of <i>Pseudomonas putida</i> Reveals the Metabolic and Genetic Diversity of the Species
  preprints 2025 置信度 0.74
• Enabling strong acetogenic growth on CO ₂ and H ₂ : H ₂ solubility limits <i>Clostridium ljungdahlii</i> growth on CO ₂ and H ₂
  preprints 2025 置信度 0.74
• Genetically-programmed Hypervesiculation of <i>Lactiplantibacillus plantarum</i> Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model
  preprints 2025 置信度 0.74
• Unraveling and overcoming the ammonia toxicity in methanotrophs for sustainable biomanufacturing and methane removal
  Replacement of nitrate with ammonium at large scale cultivation of methanotrophs can improve the economic feasibility of these bacteria in methane-based biomanufacturing and methane removal. However, ammonia toxicity and N 2 O emission impede this option. The …
  preprints Haili Zhang, Zixi Gao, Xi Xiao, Minggen Cheng 等 2025 置信度 0.74
• Forging a Xeno-Free Future for Cell-Culture Based Vaccines and Biopharmaceuticals
  preprints 2025 置信度 0.74
• A review on quantitative process analytical technology for continuous downstream processing of monoclonal antibodies
  preprints 2025 置信度 0.74
• Agentic Lab: An Agentic-physical AI system for cell and organoid experimentation and manufacturing
  Reproducibility in biological research and manufacturing remains constrained by the complexity of multi-step protocols, fragmented data-analysis pipelines, and the intrinsic variability of experimental execution. Here, we present Agentic Lab, an agentic-physic…
  preprints 2025 置信度 0.74
• Pioneer factor FOXA1 can boost CHO cell productivity
  preprints 2025 置信度 0.74
• Expression screening and functional verification of recombinant hirudin from novel chassis cell <i>Chlamydomonas reinhardtii</i>
  preprints 2025 置信度 0.74
• Directing fratricide within T cell products using an anti-uPAR chimeric antigen receptor to drive the production of potent therapeutic cells
  preprints 2025 置信度 0.74
• Feedstock-Efficient Conversion through Hydrogen and Formate-Driven Metabolism in <i>Escherichia coli</i>
  preprints 2025 置信度 0.74
• Enabling Plasmid-based Expression in <i>Clostridium kluyveri</i> using a Biparental Methylation-Conjugation System
  preprints 2025 置信度 0.74
• Genetically encoded RNA strand exchange circuits for programmable protein expression and computation in cells
  preprints 2025 置信度 0.74
• Evaluation of Bacterial Microcompartment Cofactor Recycling and Permeability with a Model Guided <i>In Vitro</i> Assay
  preprints 2025 置信度 0.74
• Synergies in Green Bioprocessing: A Comprehensive Review of Heterologous Protein Expression and the Transformative Potential of Natural Deep Eutectic Solvents
  preprints 2025 置信度 0.74
• Enhancing Lipid Production in <i>Yarrowia lipolytica</i> through Continuous Fermentation and Adaptive Laboratory Evolution in Bioreactors
  preprints 2025 置信度 0.74
• Uncovering the Design Rules for Sustainable Growth of Mineralized Mycomaterials
  preprints 2025 置信度 0.74
• Construction of Probiotic Escherichia coli Nissle 1917 as a Next- Generation Expression Platform and Its Application in Therapeutic Protein Production
  preprints 2025 置信度 0.74
• RNA Binding Proteins KhpA and KhpB Interact with Small Regulatory RNAs and Affect Global Gene Expression in <i>Deinococcus radiodurans</i>
  preprints 2025 置信度 0.74
• Development of a Chemometric Platform for Mid-Infrared Fermentation Monitoring
  preprints 2025 置信度 0.74
• Exploring multiple monitoring modalities for large-scale 3D tissue cultivation in bioreactor
  preprints 2025 置信度 0.74
• Engineering light robustness: Adaptive evolution uncovers new genetic determinants of HL tolerance in <i>Synechocystis</i>
  preprints 2025 置信度 0.74
• Unlocking the Potential of Trichoderma reesei as a Super-Host for Heterologous Protein Production: Challenges, Advances and Perspectives
  preprints 2025 置信度 0.74
• UGT93s, Plant UGTs Generating Prenylated Phenolic Glycosides
  preprints 2025 置信度 0.74
• Biosynthesis of lavandulol and lavandulyl acetate in <i>Escherichia coli</i>
  preprints 2025 置信度 0.74
• Isolation of bacteria that catabolize abiotically synthesized tetroses via the formose reaction
  europepmc 2024 置信度 0.80
• A Sequence Motif Enables Widespread Use of Non-Canonical Redox Cofactors in Natural Enzymes
  preprints 2025 置信度 0.74
• Leveraging Historical Process Data for Recombinant <i>P. pastoris</i> Fermentation Hybrid Deep Modeling and Model Predictive Control Development
  preprints 2025 置信度 0.74
• Establishing <i>Vibrio natriegens</i> as a high-performance host for acetate-based poly-3-hydroxybutyrate production
  preprints 2025 置信度 0.74
• Activation-Free Upgrading of Carboxylic Acids to Aldehydes and Alcohols
  preprints 2025 置信度 0.74
• Metabolomics-informed coarse-grained model enables prediction of cell-free protein expression dynamics
  preprints 2025 置信度 0.74
• Asymmetric Dialysis: Truly unified single-pass ultrafiltration and buffer exchange
  preprints 2025 置信度 0.74
• Extracellular Vesicles as Mediators of Intercellular Communication: Implications for Drug Discovery and Targeted Therapies
  preprints 2025 置信度 0.74
• Engineering Stable Hydrogels with Polydisperse Yeast Exopolysaccharides for Embedding Cancer Spheroids
  preprints 2026 置信度 0.74
• Cytoplasmic Abundant Heat-Soluble Proteins from Tardigrades Protect Synthetic Cells Under Stress
  preprints 2025 置信度 0.74
• Constraint-based metabolic reconstruction and analysis of Synechococcus elongatus PCC 11801 and PCC 11802 for bioengineering
  preprints 2025 置信度 0.74
• Molecular characterization of unique multi-domain harbouring fungal rhodopsin for establishing their novel opto-synthetic biological usages
  preprints 2025 置信度 0.74
• Efficient Cell Factory Design by Combining Meta-Heuristic Algorithm with Enzyme-Constrained Metabolic Models
  preprints 2025 置信度 0.74
• Analysis of the economic viability and environmental impacts of a conceptual process for the recovery of lactic acid from spent media in cultivated meat production
  preprints 2025 置信度 0.74
• Genome editing of phylogenetically distinct bacteria using portable retron-mediated recombineering
  preprints 2025 置信度 0.74
• Establishing a standardized genetic toolkit for the radiation-resistant extremophile <i>Deinococcus radiodurans</i>
  preprints 2025 置信度 0.74
• Orthogonal chemical genomics approaches reveal genomic targets for increasing anaerobic chemical tolerance in <i>Zymomonas mobilis</i>
  preprints 2025 置信度 0.74
• <i>BioPKS Pipeline</i> : An integrated platform for merging the computational design of chimeric type I polyketide synthases with enzymatic pathways for chemical biosynthesis
  europepmc 2024 置信度 0.80
• Scalable 3D Bioprinting of Human Islets in a Pancreatic Decellularized Extracellular Matrix-Enriched Bioink for Beta-Cell Replacement Therapy
  preprints 2025 置信度 0.74
• An animal component free bioprocess to synthesize 3D human matrix scaffolds using mesenchymal stromal cells
  preprints 2025 置信度 0.74
• Evaluating the limitations of Bayesian metabolic control analysis
  preprints 2025 置信度 0.74
• Prediction of metabolic dynamics through deep learning and high-throughput multiomics data
  preprints 2025 置信度 0.74