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• Information Entropy of Biological Data: An Empirical Analysis
  preprints 2026 置信度 0.74
• Characterizing the Assembly and Functional Properties of Gene-Length Mixed DNA Monolayers on Electrodes for Cell-Free Expression
  preprints 2026 置信度 0.74
• Trajectory Uncertainty Framework (TUF): A Modular Framework for Identifying Transitional and Branch-Point Cell States in Single-Cell Trajectory Analysis
  preprints 2026 置信度 0.74
• scROMA: batch-aware pathway-activity inference and a ground-truth simulation framework for single-cell transcriptomics
  preprints 2026 置信度 0.74
• Biochemical Logic Computation Through Repurposing Natural bZIP Protein Interaction Networks
  Competitive protein dimerization networks offer an alternative to transcriptional genetic circuits by enabling fast molecular decision-making through direct protein-protein interactions. Implementing these networks currently requires challenging de novo protei…
  preprints Arturo Orozco-Estrada, Daniela Flores-Nuño, Gerardo Mendizabal-Ruiz, Ernesto Borrayo 等 2026 置信度 0.74
• Bespoke sustainable 3D-printed labware for enhanced handling and standardization of tumor spheroid migration and invasion assays
  preprints 2026 置信度 0.74
• A Noncanonical Reducing-Domain Architecture Defines a New Class of Modular Polyketide Synthases
  preprints 2026 置信度 0.74
• Rational assembly of synthetic marine biofilm community with chitinase production
  preprints 2026 置信度 0.74
• Ontology-driven software engineering using LLMs for knowledge graphs in engineering biology
  preprints 2026 置信度 0.74
• CsMT: a robust and streamlined CryoSPARC workflow for cryo-EM reconstruction of microtubules
  preprints 2026 置信度 0.74
• 3D bioprinting of engineered living materials in support slurries for complex free-standing structures
  preprints 2026 置信度 0.74
• Engineering a light-responsive, orthogonal Lon protease in <i>E. coli</i> for targeted protein degradation
  Optogenetic methods are powerful tools for synthetic biology, allowing light to control cellular processes. While most bacterial optogenetic systems regulate gene expression at the transcriptional level, relatively few enable post-translational control, which …
  preprints 2026 置信度 0.74
• Synthetic activation of gibberellin signaling reveals spatial coordination of root growth
  preprints 2026 置信度 0.74
• Multiparameter optimization extends the lifetime of cell-free protein synthesis in a high-throughput format
  preprints 2026 置信度 0.74
• <i>De novo</i> design of transmembrane accessory subunits for fold stabilization and expansion
  preprints 2026 置信度 0.74
• The role of theory in biology: How you can be, and likely already are, a theoretician
  preprints 2026 置信度 0.74
• Splice-Aware Optimization Prevents Pervasive Missplicing of Natural and Synthetic cDNAs
  preprints 2026 置信度 0.74
• UstiGate: Next generation toolkit for advanced genetic engineering of the basidiomycete chassis <i>Ustilago maydis</i>
  preprints 2026 置信度 0.74
• Host-Informed Engineering of Glycosylation in Komagataella phaffii for Human Biantennary N-Linked Glycans
  preprints 2026 置信度 0.74
• A membrane-bound aromatic <i>O</i> -prenyltransferase catalyzes the last reaction step in citrus auraptene biosynthesis
  preprints 2026 置信度 0.74
• Developing a Modular MicroRNA Biosensor in E. coli for Early Cancer Diagnosis
  Abstract Early diagnosis of cancer can be facilitated by detecting microRNA (miRNA) biomarkers that are dysregulated during tumor development. Here we present a general-purpose whole-cell biosensor platform for miRNA detection, engineered in Escherichia coli a…
  preprints 2026 置信度 0.74
• A high-level programming language for generative biology with Proto
  preprints 2026 置信度 0.74
• Programmable synthetic cytokine receptors polarize macrophages to user-defined functional states
  preprints 2026 置信度 0.74
• Maximally Divergent Synonymous Gene Design with SIRIUS
  Abstract The design of maximally divergent DNA sequences translating into the same protein is a critical problem in synthetic biology. Current design tools that rely on heuristics or machine learning often fail to effectively minimize the length of shared subs…
  preprints Amirsadra Mohseni, Ian Wheeldon, Stefano Lonardi 2026 置信度 0.74
• Breaking the Synthesis Barrier for AI-Designed DNA Libraries
  preprints 2026 置信度 0.74
• Ecological constraints to mirror life
  preprints 2026 置信度 0.74
• Purinergic signaling disrupts emergent patterns of multicellular coordination in basal Xenobots
  preprints 2026 置信度 0.74
• Combinatorial Optimization of Promoters and Anchoring Proteins Drives a 10-Fold Enhancement in Yeast Surface Display of eGFP
  preprints 2026 置信度 0.74
• Mechanical interaction enables a collective mode of protocell proliferation
  preprints 2026 置信度 0.74
• Modular Assembly of an Infectious Clone of the Akata strain of EBV using Synthetic Genomics Methods in Yeast
  preprints 2026 置信度 0.74
• A modular live-cell biosensor for extracellular protease activity
  preprints 2026 置信度 0.74
• Deep Mutational Scanning of the GPCR Rhodopsin Reveals Pleiotropic Mutational Effects and Their Roles in Modulating Light Sensitivity
  preprints 2026 置信度 0.74
• Establishing a genetic part library for tunable double-stranded RNA circuit construction and RNA interference in <i>Caenorhabditis elegans</i>
  RNA interference (RNAi), one of the major molecular tools in model nematode Ceanorhabditis elegans, relies on feeding engineered bacteria that express double-stranded RNA (dsRNA), which modulates animal host gene expression in a programmable manner. Currently …
  preprints 2026 置信度 0.74
• High-efficiency, site-specific integration of kilobase-scale DNA into plant genomic safe harbors via PrimeStack editors
  preprints 2026 置信度 0.74
• Theoretical framework and experimental demonstration of sustainable in vitro regeneration of major translation factors EF-Tu and IF3
  preprints 2026 置信度 0.74
• Combinatorial and Inducible CRISPRa/i Enables Canalized hiPSC Forward Programming and Iterative Refinement <i>via</i> Single-Cell Genomics
  preprints 2026 置信度 0.74
• PKProbDesign: RNA inverse folding including pseudoknots by optimizing thermodynamic folding probability
  preprints 2026 置信度 0.74
• ProHiFlo: Hierarchical Flow Matching with Functional Guidance for De Novo Protein Generation
  preprints 2026 置信度 0.74
• A Comprehensive Epidermal Map from a Poplar Single-Cell Shoot Atlas Reveals New Trichome-Specific Genes
  preprints 2026 置信度 0.74
• AI-enabled rhodopsin design for blue-light enhanced bacterial growth
  preprints 2026 置信度 0.74
• Engineering an Enzymatically Active Granular Matrix for On-Chip Modeling of Bone-Like Mineralization
  preprints 2026 置信度 0.74
• BxbI-mediated insertion of a 77kb human RET sensitive haplotype into the mouse genome to generate a humanized model of Hirschsprung disease
  preprints 2026 置信度 0.74
• Lipid-conjugated DNA enables on-demand delivery of lipids and proteins to synthetic cells
  Abstract The bottom-up construction of synthetic cells based on giant unilamellar vesicles (GUVs) is a central goal in synthetic biology. Achieving targeted changes in membrane and cytoplasmic composition with temporal control remains challenging however. DNA-…
  preprints Bert Van Herck, Jacob Kerssemakers, Nikolaj A. Risgaard, Stefan Vogel 等 2026 置信度 0.74
• A cuffed CRISPR guide RNA for microRNA activity-dependent genome editing
  preprints 2026 置信度 0.74
• Impact of Coding Region Accessibility and Uridine Chemistry on Translation in mRNA–DNA Hybrid Origami
  preprints 2026 置信度 0.74
• Live-cell imaging of enhancer-promoter dynamics reveals transient contact-driven gene activation
  preprints 2026 置信度 0.74
• Cryptochrome radical pairs as quantum reservoirs: information-processing capacity, classical baselines, and a microsecond memory bound on neural computation
  preprints 2026 置信度 0.74
• Decoding universal principles of codon-mediated regulation of gene expression
  preprints 2026 置信度 0.74
• Active Learning–Guided Peptide Design for Modulating Condensate Properties upon Recruitment
  preprints 2026 置信度 0.74
• Certified Steady-State Parameter-Interval Design for Uncertain Biomolecular Models using a Global Shaving Contractor
  Abstract The design of parameter intervals that provably enforce steady-state specifications in biomolecular circuits is challenging due to nonlinear reaction kinetics, parametric uncertainty, and the under-determined nature of steady-state constraints. Most v…
  preprints Rudra Prakash, S. Janardhanan, Shaunak Sen 2026 置信度 0.74
• Split-Indigoidine synthetase as optical reporter for benchmarking protein-protein interactions
  preprints 2026 置信度 0.74
• A Cofactor-Activated Molecular Switch for Condensate Biogenesis and Catalysis <i>in Escherichia coli</i>
  preprints 2026 置信度 0.74
• Dual-Plasmid Engineering of <em>Synechococcus sp. PCC 7002</em> for Heterologous Methane Oxidation and Urban Greenhouse Gas Bioremediation
  preprints 2026 置信度 0.74
• Multiplexed construction of defined DNA products from unpartitioned oligonucleotide pools
  preprints 2026 置信度 0.74
• Genetic code expansion enables programmable covalent protein design
  preprints 2026 置信度 0.74
•  A Versatile Genetic Toolkit for the Deep-Sea Fungus Penicillium janthinellum SH0301
  preprints 2026 置信度 0.74
• Evolutionary transfer learning enables organism-wide inference of mammalian enhancer landscapes
  preprints 2026 置信度 0.74
• Short single-stranded DNA oligonucleotides enable intracellular transcription of functional RNAs in mammalian cells
  preprints 2026 置信度 0.74
• 1100 Synthetic Benchmark Problems for Dynamic Modeling of Cellular Processes
  preprints 2026 置信度 0.74
• Crystal structures of a far-red photoreceptor in different light-absorbing states: insights into spectral tuning and light signaling
  preprints 2026 置信度 0.74
• Genome-scale community metabolic modeling of maize root-associated microbiota shows that root exudates stimulate diverse metabolic interactions
  preprints 2026 置信度 0.74
• From Jurassic Germs to Gymnosperms: A Speculative Strategy for Reconstructing Dinosaur Genomes
  preprints 2026 置信度 0.74
• Complete elucidation and heterologous reconstruction of the biosynthetic pathway of camptothecin
  preprints 2026 置信度 0.74
• A comprehensive reference database to support untargeted metabolomics in <i>Pseudomonas putida</i>
  preprints 2026 置信度 0.74
• Behavioral, Physiological, and Transcriptional Mechanisms of Memory in a Synthetic Living Construct
  Abstract Synthetic living constructs, which lack the long histories of selection in ecological contexts that shape behaviors of conventional organisms, offer an important complement to traditional studies of learning. Could novel biobots exhibit sensing and me…
  preprints Vaibhav P. Pai, James A. Traer, Megan M. Sperry, Yuxin Zeng 等 2026 置信度 0.74
• A Low-Cost, High-Throughput Design-Build-Test Pipeline for Engineering Genetic Systems: Stress Testing with Complex Structural Proteins
  preprints 2026 置信度 0.74
• Unmasking the Black Box: Computational Evidence Identifying Mitochondrial ATP Synthase Subunit β as a High-Confidence Target of Glycyrrhetinic Acid Analogs Against Brugia malayi
  preprints 2026 置信度 0.74
• Synthetic budding morphogenesis by optogenetic receptor tyrosine kinase signaling
  preprints 2026 置信度 0.74
• Adaptive laboratory evolution of a minimal cell to low temperature
  preprints 2026 置信度 0.74
• Genetic Programming of Bacterial Microcompartments: Operon Order as a Tool for Nanoscale Morphogenesis
  Abstract Gene order is a powerful design principle for protein nanomachines. In nature, gene organisation ensures the precise assembly of functional protein nanostructures. We demonstrate how genetic repositioning of the key structural gene pduN , within the o…
  preprints Dimple Goel, Preeti Negi, Aarcha Radhakrishnan, Sharmistha Sinha 2026 置信度 0.74
• When Do Distance-Based Methods Fail? Empirical Scaling Laws and Actionable Thresholds for High-Dimensional Data Mining
  preprints 2026 置信度 0.74
• Implementation of Probiotic Bacteria for Monitoring Intestinal Inflammation
  Abstract Inflammatory bowel diseases (IBD) are characterized by chronic intestinal inflammation, driving a need for real-time, noninvasive monitoring of inflammatory biomarkers. Here we propose a Lactobacillus-based probiotic biosensor engineered to detect mol…
  preprints 2026 置信度 0.74
• Genome-Wide Identification and Functional Verification of Core <em>BBEL</em> Genes for BIA Biosynthesis in <em>Corydalis saxicola</em> Bunting
  preprints 2026 置信度 0.74
• 3′ Exonuclease-mediated DNA assembly at room temperature and below
  preprints 2026 置信度 0.74
• Green hydrothermal synthesis of Aralia elata leaf extracts functionalized Ag/Au nanomaterials and their application
  preprints 2026 置信度 0.74
• Genome Mining Reveals a Large Putative Hybrid NRPS–T1PKS–Terpene Biosynthetic Gene Cluster in <em>Brevibacillus laterosporus</em> SA14 (TISTR 2453)
  preprints 2026 置信度 0.74
• Coupled intracellular redox and extracellular respiration sensing for quantitative oxidative stress profiling
  preprints 2026 置信度 0.74
• ProNotch converts extracellular protease activity into programmable transcriptional outputs
  preprints 2026 置信度 0.74
• Noise analysis of derivative-action biomolecular topologies
  preprints 2026 置信度 0.74
• Striping artifact removal in VisiumHD data through nuclear counts modeling
  preprints 2026 置信度 0.74
• Bispecific Coiled-Coil Reporters Enable Rapid, Multiplexed Detection of Mycoplasma via Toehold Switch Sensors
  preprints 2026 置信度 0.74
• From Editing Genes to Orchestrating Networks: CRISPR and the Future of Precision Oncology
  preprints 2026 置信度 0.74
• Agentic systems are adept at solving well-scoped, verifiable problems in computational biology
  preprints 2026 置信度 0.74
• Selective Editing and Functionalization of the Mammalian Lipidome
  preprints 2026 置信度 0.74
• A droplet microfluidic-based platform for enhanced DNA delivery in non-model organisms
  preprints 2026 置信度 0.74
• The Role of Zinc and Junctional Adhesion Molecule a Protein in Platelet Plug Formation
  preprints 2026 置信度 0.74
• Transcription terminators with context-dependent promoter and terminator activities
  preprints 2026 置信度 0.74
• Long-term stability of soil microbiome structure and function in liquid soil extracts
  preprints 2026 置信度 0.74
• MrtR of <i>Mesorhizobium tianshanense</i> reveals both activation and inhibition mechanisms of a LuxR-type quorum sensing receptor
  preprints 2026 置信度 0.74
• Demixing of bacterial CipA and CipB proteins in mammalian cell cytosol provides an orthogonal self-assembly platform for producing isolable multi-phase intracellular crystals
  preprints 2026 置信度 0.74
• A phage-derived promoter SD13 enables strong and cross-host gene expression in Streptomyces and Escherichia coli
  preprints 2026 置信度 0.74
• Nitrogenase regulation in <i>Vibrio natriegens</i> differs from other γ-proteobacteria
  preprints 2026 置信度 0.74
• Small but Mighty: The Surprising Metabolic Range of a Bacterial Microcompartment
  preprints 2026 置信度 0.74
• Deep Learning-Guided Reverse Translation Enhances Soluble Expression of Recombinant Proteins in<em> Escherichia coli</em>
  preprints 2026 置信度 0.74
• Robustness of Biological Systems: A New Class of Compensation Mechanisms for Compromised Polycomb Function by miRNA-Dependent Feed-Forward Loops
  preprints 2026 置信度 0.74
• Zero-shot biological reasoning with open-weights large language models reproduces CRISPR screen based prediction of synthetic lethal interactions
  preprints 2026 置信度 0.74
• TolC is required for a Mixed-Linkage β-Glucan (MLG) biosynthesis: Engineering bacteria for MLG overproduction
  preprints 2026 置信度 0.74
• Learning the structural diversity in random protein sequence space
  preprints 2026 置信度 0.74
• FalseAmpHunter: A Bioinformatics Pipeline for Detecting and Characterizing False Amplicons in PCR
  preprints 2026 置信度 0.74
• Modular Deep Learning for Direct RNA Sequence Design via Self-Contained RNA Units
  preprints 2026 置信度 0.74