-
crossref
2026-05-15T07:27:57Z
置信度 0.70
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crossref
2026-01-16T08:24:34Z
置信度 0.70
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crossref
2026-03-20T07:21:55Z
置信度 0.70
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crossref
2026-06-19T07:31:37Z
置信度 0.70
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crossref
2026-01-16T08:24:34Z
置信度 0.70
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crossref
2026-06-19T07:31:37Z
置信度 0.70
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crossref
2026-07-17T12:55:41Z
置信度 0.70
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crossref
2026-02-20T08:30:26Z
置信度 0.70
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crossref
2026-04-17T07:26:08Z
置信度 0.70
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crossref
2026-06-04T21:31:26Z
置信度 0.70
-
Abstract Biocircuit functions are often valid only in specific parameter regimes, yet these regimes are rarely made explicit. We use a holistic analysis method based on regimes to derive validity conditions and introduce the Realizability Index ( R -index), qu…
crossref
Qinguo Liu, Xinying Ren, Fangzhou Xiao
2026-01-22T07:00:37Z
置信度 0.70
-
Synthetic gene circuits are engineered DNA sequences that control when genes turn on and how much they are expressed, alongside the regulatory machinery of cells. Many gene circuits use feedback, such that the molecules produced by a gene increase or decrease …
crossref
Ania-Ariadna Baetica
2026-07-08T22:14:14Z
置信度 0.70
-
Synthetic gene circuits are key elements of engineered biological systems that allow us to control and program cellular behavior. Yet, circuit design can be challenging to newcomers due to the numerous design choices and the abundance and variety of parameters…
crossref
Javier Santos-Moreno
2026-07-08T22:24:35Z
置信度 0.70
-
crossref
Zekun Li, Nicole M Petersen, Eric M Young
2026-07-21T21:49:06Z
置信度 0.70
-
crossref
William B. Miller, František Baluška, Predrag Slijepčević, Arthur S. Reber
2026-07-02T12:29:18Z
置信度 0.70
-
Abstract DNA nanotechnology is based on programmable base pairing, resulting in the precise construction of nanoscale structures. Sequence variability in DNA nanostructure self-assembly is achieved by the use of xeno nucleic acids, chemically modified bases an…
crossref
Arun Richard Chandrasekaran
2026-06-08T05:10:33Z
置信度 0.70
-
Chapter 3 of the National Academies report on AIxBio: Biosecurity implications for what AI can and can't do in biology today.
crossref
Stephen D. Turner
2026-02-08T13:04:48Z
置信度 0.70
-
Chapter 3 of the National Academies report on AIxBio: Biosecurity implications for what AI can and can't do in biology today.
crossref
Stephen D. Turner
2026-02-08T13:04:48Z
置信度 0.70
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crossref
Yuefeng Ma, Leshan Yang, Yifan Dai
2026-07-08T22:09:23Z
置信度 0.70
-
crossref
Abdalmalek Adnan Alnator, Asiya Nazir
2026-06-12T09:42:20Z
置信度 0.70
-
crossref
Hongwu Ma
2026-07-30T08:01:07Z
置信度 0.70
-
crossref
Satyendra Singh, Kirti Baghel, Vijay Kumar Prajapati
2026-05-17T22:36:55Z
置信度 0.70
-
crossref
2026-07-08T22:05:17Z
置信度 0.70
-
Over the next few decades, there is a compelling need to build a new sustainable energy infrastructure to replace the fossil fuel system that we have relied on since the 1700s. This infrastructure must not only replace what exists but far exceed its capabiliti…
crossref
Buz Barstow, Gretchen Vengerova
2026-03-20T01:01:23Z
置信度 0.70
-
<p><span>Pakistan's economic and security vulnerabilities, stemming from climate instability, agricultural degradation, and biomedical dependence, demand transformative policy intervention. Synthetic biology, which integrates molecular engineering …
crossref
Jibran Ali
2026-08-13T17:48:58Z
置信度 0.70
-
Synthetic biology, defined as the construction of biological systems engineered through the understanding of existing life forms, represents a transformative shift from traditional "artisan" gene editing to a rigorous engineering discipline. While the field pr…
crossref
Michael Sun
2026-03-10T10:28:30Z
置信度 0.70
-
crossref
Kavita Yadav, Vikash Kumar Yadav, Nadanai Laohakunakorn, Bhanvi Kumawat
2026-05-17T22:45:41Z
置信度 0.70
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crossref
Aneela Mustafa, Tayaba Irfan, Mustafeez Mujtaba Babar, Jayakumar Rajadas
2026-05-17T22:17:02Z
置信度 0.70
-
Synthetic gene circuits consist of engineered networks of genes and proteins. The function of these circuits can be tuned by regulating the expression levels of key circuit components. Light is an ideal signal for controlling expression levels in these circuit…
crossref
Timothy H. Wakiyama, Megan N. McClean
2026-07-08T22:16:11Z
置信度 0.70
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ABSTRACT Oncolytic viruses (OVs) are promising cancer therapeutics that selectively infect and lyse tumor cells while sparing normal tissues and stimulating antitumor immunity. However, their efficacy remains limited by suboptimal cytolytic activity and insuff…
crossref
A. Agaoua, C. Rey, J. Hortelano, A-I Moro 等
2026-03-07T04:40:52Z
置信度 0.70
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Abstract Like proteins, RNAs have been a target for exploitation to generate synthetic molecules that can adopt enhanced and novel functions 1 . High-throughput assays 2 , combined with meticulous biochemistry, have led to the generation of some artificial RNA…
crossref
Louie N. Pinpin, Yousuf A. Khan
2026-04-24T05:55:12Z
置信度 0.70
-
crossref
Rugvedi P. Kadu, Krushna Shinde, Ambadas B. Rode
2026-05-18T00:41:14Z
置信度 0.70
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crossref
Yukti Singh, Saumya Agrawal, Sandhya Mehrotra, Rajesh Mehrotra
2026-05-18T00:28:35Z
置信度 0.70
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crossref
Mohammad Nadeem Khan
2026-05-29T12:09:26Z
置信度 0.70
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crossref
Rongming Liu, Cheng Yu, Peiyao Cao, Hongle Wang 等
2026-05-17T22:08:40Z
置信度 0.70
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crossref
Dimitrios Kaloudas, Martina Traykovska, Nikolet Pavlova, Robert Penchovsky
2026-05-17T23:37:35Z
置信度 0.70
-
ABSTRACT The analysis of large gene and metabolic networks is often hindered by unknown biochemical parameters and the nonlinear nature of classical S-system models. To address this, we introduce a framework based on combinatorial toric geometry computed with …
crossref
Marco Polo Castillo-Villalba
2026-02-05T02:05:22Z
置信度 0.70
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crossref
Gholamreza Abdi, Kirtan Dave, Saloni Gautam, Unnati Panchal
2026-05-17T22:32:58Z
置信度 0.70
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crossref
Ranbir Chander Sobti, Ram Krishan Negi, Anita Rana
2026-05-27T10:34:59Z
置信度 0.70
-
Synthetic biology, as an emerging field that integrates life sciences and engineering technology, is driving profound transformations in global science, ethics, and legal systems. In international legal framework, the Biological Weapons Convention (BWC) and th…
openalex
Yu Qin, Jiaxiang Hu, Kezhen Su
2025-12-04
置信度 0.72
Soft lawHard lawCorporate governanceInternational lawScope (computer science)
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
Despite the fact that microbes in natural environments spend most of their time in growth arrest, we understand little about how this physiological state affects the performance of engineered genetic circuits. Here, we measure repression curves from a library …
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
preprints
2024
置信度 0.74
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preprints
2026
置信度 0.74
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preprints
2025
置信度 0.74
-
ABSTRACT R is widely used in statistical computing, data analysis, and bioinformatics. A key contributor to its success in bioinformatics and computational biology is the open-source project Bioconductor. As of its latest release (3.20), the Bioconductor commu…
preprints
2025
置信度 0.74
-
preprints
2025
置信度 0.74
-
ABSTRACT Evolutionary studies in bacteria have emphasized genetic and metabolic diversity, while cell-size variation has received less attention. Here we introduce MEDUSSA, a high-throughput method for precise bacterial cell-size profiling based on automatic s…
preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2026
置信度 0.74
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preprints
2026
置信度 0.74
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preprints
2026
置信度 0.74
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preprints
2024
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2024
置信度 0.74
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preprints
2026
置信度 0.74
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preprints
2026
置信度 0.74
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preprints
2024
置信度 0.74
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preprints
2024
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2024
置信度 0.74
-
preprints
2024
置信度 0.74
-
The crucial role of the gut microbiome in human health has driven a need to understand bacterial function within their complex native ecosystem. However, traditional functional genomic methods require isolating, cultivating, and modifying bacteria in vitro bef…
pubmed
Maire A, Laurenceau R, Rolhion N, Bikard D
2026
置信度 0.82
-
europepmc
2026
置信度 0.80
-
Bottom-up synthetic biology has achieved remarkable success in designing molecular architectures at the nanoscale. However, constructing functional, cell-sized artificial systems at the mesoscale remains a significant challenge due to the stochastic nature of …
pubmed
Suzuki H
2026
置信度 0.82
-
The dynamic glycan layer that surrounds human and microbial cells plays an essential role in the immune system's capacity to maintain immune tolerance and equilibrium, fight pathogens and cancer. Endogenous anti-glycan antibodies are an indispensable part of i…
pubmed
Weber F, Valenti A, Ledvinka J, Moscovitz O 等
2026
置信度 0.82
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
Synthetic double-stranded RNA (dsRNA) analogues function as viral mimetics that activate innate immune signaling pathways critical for antiviral defense and the induction of adaptive immunity. Among dsRNA analogues, polyinosinic:polycytidylic acid [poly(I:C)] …
pubmed
Kayesh MEH, Kohara M, Tsukiyama-Kohara K
2026
置信度 0.82
-
Synthetic microbial community (SynCom) biosensors are emerging from the convergence of whole-cell biosensing, synthetic ecology, and computational design. Conventional whole-cell biosensors (WCBs) use a single microbial chassis to convert analyte recognition i…
pubmed
Hu L, Yang Y, Xia S, Mao W 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
The environmental challenges associated with fossil fuel-derived plastics have intensified the demand for sustainable and biodegradable alternatives. Poly(glycolic acid) (PGA) is a promising substitute for conventional plastics, but its industrial production i…
pubmed
Zhao M, Shang J, Pan X, Wang X 等
2026
置信度 0.82
-
The oak lace bug, Corythucha arcuata (Say, 1832) (Hemiptera: Tingidae), has emerged as an ecologically disruptive invasive pest across Eurasian Quercus forests, severely impairing foliar photosynthetic capacity and overall woodland vitality. By systematically …
pubmed
Stancă-Moise C
2026
置信度 0.82
-
Natural products (NPs) are an indispensable source of therapeutic agents, occupying a privileged and structurally diverse region of the Biologically Relevant Chemical Space (BioReCS) that is underexplored by synthetic compound libraries. This comprehensive rev…
datacite
natural product chemistry
2026
置信度 0.66
natural productsdrug discoverychemical spaceBioReCShigh-throughput screening
-
Natural products (NPs) are an indispensable source of therapeutic agents, occupying a privileged and structurally diverse region of the Biologically Relevant Chemical Space (BioReCS) that is underexplored by synthetic compound libraries. This comprehensive rev…
datacite
natural product chemistry
2026
置信度 0.66
natural productsdrug discoverychemical spaceBioReCShigh-throughput screening
-
Version 2 — revised in response to an external structural review and an automated critique pass. See "Response to Review" appendix in the PDF for the change log. A recurring structural problem cuts across several recent preprints in molecular network biology, …
datacite
Saluca Agentic AI Research Team
2026
置信度 0.66
AI-drafted synthesisarXivpreprint reviewv2
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This article provides a comprehensive overview of the evolution of modern experimental biochemistry, tracing its journey from foundational principles to today's integrated, high-throughput science. It begins by exploring the historical schism and recent synthe…
datacite
biochemical science
2026
置信度 0.66
Experimental BiochemistryEvolutionary BiochemistryCRISPR-Cas9Multi-OmicsAlphaFold
-
This article provides a comprehensive overview of the evolution of modern experimental biochemistry, tracing its journey from foundational principles to today's integrated, high-throughput science. It begins by exploring the historical schism and recent synthe…
datacite
biochemical science
2026
置信度 0.66
Experimental BiochemistryEvolutionary BiochemistryCRISPR-Cas9Multi-OmicsAlphaFold
-
Drawing from Kariko et al.’s 2008 suggestion to explore DNA adjuvants with modified mRNA, ` this Review synthesizes research on DNA adjuvanticity, antigen-presenting cell biology, and crosspresentation challenges to examine whether manufacturing residuals coul…
datacite
Mueller, Siguna
2026
置信度 0.66
mRNA-LNP vaccinesCD8 T cell immunitytype I interferon dual natureantigen-adjuvant co-signalingCpG DNAs
-
Drawing from Kariko et al.’s 2008 suggestion to explore DNA adjuvants with modified mRNA, ` this Review synthesizes research on DNA adjuvanticity, antigen-presenting cell biology, and crosspresentation challenges to examine whether manufacturing residuals coul…
datacite
Mueller, Siguna
2026
置信度 0.66
mRNA-LNP vaccinesCD8 T cell immunitytype I interferon dual natureantigen-adjuvant co-signalingCpG DNAs
-
The expression “radiation-eating bacteria” is frequently used in popular science to describe microorganisms that survive, interact with, or potentially benefit from high-radiation environments. Scientifically, however, the phrase is imprecise. The best-charact…
datacite
Safeer Abd Alkreem Abd, Aminah Kadhum Murad, Entesser Farhan Salman
2026
置信度 0.66
-
The expression “radiation-eating bacteria” is frequently used in popular science to describe microorganisms that survive, interact with, or potentially benefit from high-radiation environments. Scientifically, however, the phrase is imprecise. The best-charact…
datacite
Safeer Abd Alkreem Abd, Aminah Kadhum Murad, Entesser Farhan Salman
2026
置信度 0.66
-
Bacterial infections remain a major global health challenge, driving continuous innovation in antibacterial therapy. Traditional agents such as β-lactams, aminoglycosides, and fluoroquinolones have provided decades of clinical success, yet the rapid emergence …
datacite
Kunal Deep Prajapat, Bhanu Pratap Singh, Nidhi Khatri, Rahul Kumar Kumawat
2026
置信度 0.66
Antibacterial agents, drug resistance, novel drug classes, nanotechnology, antimicrobial peptides, bacteriophage therapy, CRISPR-Cas, drug delivery systems, β-lactamase inhibitors; multidrug resistance; stewardship, synthetic biology.
-
Bacterial infections remain a major global health challenge, driving continuous innovation in antibacterial therapy. Traditional agents such as β-lactams, aminoglycosides, and fluoroquinolones have provided decades of clinical success, yet the rapid emergence …
datacite
Kunal Deep Prajapat, Bhanu Pratap Singh, Nidhi Khatri, Rahul Kumar Kumawat
2026
置信度 0.66
Antibacterial agents, drug resistance, novel drug classes, nanotechnology, antimicrobial peptides, bacteriophage therapy, CRISPR-Cas, drug delivery systems, β-lactamase inhibitors; multidrug resistance; stewardship, synthetic biology.
-
Danazol, a synthetic androgen-derived steroid with distinctive structural and pharmacological properties, has maintained clinical relevance for over four decades despite significant therapeutic advances in its primary indications. Originally developed for the …
datacite
Indunil Karunarathna
2026
置信度 0.66
-
Danazol, a synthetic androgen-derived steroid with distinctive structural and pharmacological properties, has maintained clinical relevance for over four decades despite significant therapeutic advances in its primary indications. Originally developed for the …
datacite
Indunil Karunarathna
2026
置信度 0.66
-
Geometric Information Dynamics (GID): A Control-Based, THD-Integrated Framework for Detecting Coherent Geometric Communication Kevin L. BrownAugust 202510.5281/zenodo.16945628 Informational Physics Ontology Paper Abstract Geometric Information Dynamics (GID) p…
datacite
Brown, Kevin
2025
置信度 0.66
-
The landscape of pharmaceutical research is undergoing a fundamental shift driven by the integration of synthetic biology (SB). Rather than relying solely on traditional chemical synthesis or the direct extraction of natural products, this discipline treats bi…
datacite
Meher N. Tamboli*, Ms. Kalyani J. Bhor, Hemlata S. Pingat, Rajshree V. Satpute, Nutan M. Shinde
2026
置信度 0.66