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• Growth costs of protein allocation in models of growing cells
  preprints 2026 置信度 0.74
• A minimal‑component E. coli cell‑free transcription–translation system: implications for democratization
  preprints 2026 置信度 0.74
• kinGEMs: A Robust and Scalable Framework for Resource-Constraint Models through Stochastic Tuning of Deep Learning-Predicted Kinetic Parameters
  preprints 2026 置信度 0.74
• Genetically Programmed Shape-morphing of Engineered Living Materials
  preprints 2026 置信度 0.74
• De Novo Design and In Silico Validation of a Cationic Antimicrobial Peptide Using an AI-Guided Framework for Membrane Thermodynamics and Hemolytic Toxicity
  preprints 2026 置信度 0.74
• A Generative AI Framework to Predict Cardiomyocyte Contraction Function from Single Static Images
  preprints 2026 置信度 0.74
• A Minimal Regulatory Spatial Model for Emergent Multicellular Organization in Dissipative Environments
  preprints 2026 置信度 0.74
• Metabolic commitment and nitrogen control of diazotrophy in the diazoplast-containing diatom <i>Epithemia adnata</i>
  preprints 2026 置信度 0.74
• In vitro evolution of DNA operators enables multivalency protein−DNA interactions: towards programmable transcription factor regulation
  ABSTRACT In vitro transcription (IVT) systems regulated by allosteric transcription factors (aTFs) are central to emerging cell-free biosensing and synthetic biology platforms, yet their performance is often limited by suboptimal protein–DNA interactions and t…
  preprints 2026 置信度 0.74
• Evolutionary Stratification of Codon Usage Bias In Plants Arises from GC3 Composition and Translational Optimization
  preprints 2026 置信度 0.74
• Functional-group-convergent synthesis of amides
  preprints 2026 置信度 0.74
• Expanding the chemical diversity of RNA by transcriptional incorporation of amino acid- and glycosyl-modified nucleotides
  preprints 2026 置信度 0.74
• Generalist method to reconstruct metabolic networks from multi-omics data at large-scale
  preprints 2026 置信度 0.74
• Propagation of Benchmarking Uncertainty Through Downstream Analysis: From Network Inference Ranking to Biological Discovery
  preprints 2026 置信度 0.74
• Synthetic germ granules reveal a direct role of Vasa/DDX4 in RNA localization and translational activation
  preprints 2026 置信度 0.74
• Engineering a PD-L1–sensing synthetic receptor for programmable macrophage-mediated phagocytosis
  ABSTRACT Macrophages are abundant immune cells within the tumor microenvironment with intrinsic phagocytic capabilities, yet their antitumor functions are frequently suppressed by inhibitory signals. Synthetic biology enables the rational design of ligand-resp…
  preprints De Martino Ilaria, Russo Luigi, Marchetti Matteo, Siciliano Velia 2026 置信度 0.74
• Fundamental limitations of genomic language models for realistic sequence generation
  preprints 2026 置信度 0.74
• Engineering Auronidin Production in Marchantia polymorpha Enables a New Class of Plant-Derived Textile Pigments.
  Plant-derived pigments offer sustainable alternatives to synthetic colorants, yet their practical deployment in textiles is limited by restricted chemical diversity and low abundance. Liverworts represent a source of diverse chemical compounds, and the model l…
  europepmc 2026 置信度 0.80
• Global incorporation of synthetic adenosine analogs reveals poly(A)-dependent translation differences in mRNA.
  europepmc 2026 置信度 0.80
• PCRD-seq: proximity crosslinking-induced RNA depletion sequencing for low-input chromatin-associated transcriptome profiling.
  europepmc 2026 置信度 0.80
• The emerging dialogue between synthetic genomics and clinical research.
  pubmed Liu Y, Yuan YJ 2026 置信度 0.82
• Network Properties Influence Covariance Between Gene Expression and Fecundity Fitness of Caenorhabditis elegans in a Novel Laboratory Environment.
  europepmc 2026 置信度 0.80
• Synergistic heterotrophic-photomixotrophic cultivation enhances fucoxanthin production in Poterioochromonas malhamensis (golden microalga).
  europepmc 2026 置信度 0.80
• Computational design and experimental validation of peptide inhibitors targeting the p53-COP1 interaction to suppress p53 ubiquitination.
  Breast cancer, as one of the most prevalent malignant tumors among women, is a leading cause of female mortality. Inhibiting the ubiquitination of p53 protein would be helpful to control the development and progression of breast cancer, as p53 is crucial for r…
  pubmed Liu Q, Zhang L 2026 置信度 0.82
• Enzyme fusion-based enhancement of ene-reductase activity for chiral α-substituted carboxylic acid production.
  Chiral &#x3b1;-substituted carboxylic acids are critical pharmaceutical and agrochemical intermediates, yet their efficient biosynthesis remains challenging due to kinetic imbalances in enzymatic cascades. To address this issue, we constructed fusion enzymes b…
  pubmed Guo Z, Sun Y, Yang B, Dong X 2026 置信度 0.82
• C/N ratio‑directed two‑stage mixotrophic cultivation of Isochrysis galbana for enhanced production of fucoxanthin and DHA.
  europepmc 2026 置信度 0.80
• Genomic Features, Functional Complementarity, and the Potential for Constructing Synthetic Consortia from Dominant Petroleum-Degrading Bacteria.
  europepmc 2026 置信度 0.80
• Understanding ripple effects in the gut microbiome.
  europepmc 2026 置信度 0.80
• Mechanism underlying the high regulatory performance of the doxycycline riboswitch G12.
  Synthetic riboswitches provide protein-independent, modular control of gene expression, yet selecting aptamers that reliably couple ligand binding to regulatory switching remains challenging. Here, we identify and mechanistically characterise G12, a doxycyclin…
  pubmed Hoetzel J, Walbrun A, Schäfer M, Wang T 等 2026 置信度 0.82
• Modular Scalable Synthetic Gene Circuits for Complex Functions Within Minimal Computational Layers in Human Cells.
  Engineering mammalian cells to execute complex genetic programs remains a significant challenge in synthetic biology. Synthetic gene circuits typically implement sophisticated programs through cascaded computational layers. However, these architectures require…
  europepmc 2026 置信度 0.80
• ApiRegenin, an Animal-Derived Platelet-Rich Plasma Extract, Accelerates Wound Healing of Chronic Diabetic Ulcer in Mice.
  europepmc 2026 置信度 0.80
• Epitope-guided Detection of a Molecular Glue-induced Ternary Complex Using Engineered Synthetic Antibody Fragments.
  europepmc Kelly M. O’Leary, Tomasz Slezak, Duc Anh Le, Anthony A. Kossiakoff 2026 置信度 0.80
• Large-scale synthetic data enable digital twins of human excitable cells.
  europepmc 2026 置信度 0.80
• A programmable fungal platform for engineered living textiles.
  europepmc 2026 置信度 0.80
• Molecular velcro for precision genome repair.
  europepmc 2026 置信度 0.80
• Brassinosteroid and TPD1 signaling pathways redundantly control anther lobe formation in Arabidopsis thaliana.
  europepmc 2026 置信度 0.80
• Corrigendum to "De novo biosynthesis of the polymethoxylated flavones eupatilin and jaceosidin in Saccharomyces cerevisiae" [Metabol. Eng. 97 (2026), 102502].
  europepmc 2026 置信度 0.80
• Optimization of the Extraction of Total Alkaloids From Lotus Leaves by Acidic Ethanol and Its Purification by Macroporous Resins.
  europepmc 2026 置信度 0.80
• FAM234A acts as a switch between Th17 and Treg cell fate decisions that control inflammatory bowel disease.
  Appropriate T-cell functional polarization is critical for maintaining immune stability and immune tolerance. The role of Fam234a in the functional polarization of T cells is unknown. In a DSS-induced inflammatory bowel disease model in Rag2 -/- mice with eith…
  pubmed Zhang Z, Zhao C, Sun L, Lei T 等 2026 置信度 0.82
• Machine learning-based classification model to distinguish tumor and tumor-free samples using synthetic plasma proteomic dataset.
  europepmc 2026 置信度 0.80
• P450 Disruption Reveals Unforeseen Biaryl Cross-Link Chemistry in Glycopeptide Antibiotics.
  europepmc 2026 置信度 0.80
• Machine Learning approaches for the detection of disease-causing variants in whole-genome data need to address the expression of functional genes.
  europepmc 2026 置信度 0.80
• Rethinking governance of synthetic cells.
  europepmc 2026 置信度 0.80
• Microbial Communities Across Sports Surfaces: Exploring the Biology of Athletic Environments.
  europepmc 2026 置信度 0.80
• Catalytic Promiscuity and Cascade Reaction Mechanism of Ketosteroid Isomerases for Addition Reactions of Cyclic Enones.
  europepmc 2026 置信度 0.80
• Investigating Terpene Synthase-Catalyzed Reactions with Ketone- and Alkene-Modified Substrate Analogs.
  europepmc 2026 置信度 0.80
• Engineering peroxisomal cofactor systems in Saccharomyces cerevisiae for enhanced biosynthesis of α-humulene.
  europepmc 2026 置信度 0.80
• A risk-based framework to guide oversight of nucleic acid constructs.
  europepmc 2026 置信度 0.80
• Design and optimization of a kinase-controlled allosteric switch.
  Post-translational control enables rapid and precise regulation of cell behavior. Despite these advantages, general strategies to build phosphorylation-based synthetic circuits are limited. Here we reasoned that engineered allostery, a technique that has been …
  europepmc 2026 置信度 0.80
• Synthetic communities of Yarrowia lipolytica for efficient betanin bioproduction through metabolic partitioning.
  europepmc 2026 置信度 0.80
• A RAF-SnRK2-PP2C functional module regulates cell survival in the chlorophyte Chlamydomonas reinhardtii.
  europepmc 2026 置信度 0.80
• Deep learning unlocks sequence-divergent synthetic promoters to empower Streptomyces natural product engineering.
  europepmc 2026 置信度 0.80
• Engineering a PD-L1-sensing synthetic receptor for programmable macrophage response.
  europepmc 2026 置信度 0.80
• Computational design and experimental validation of fast oligonucleotide-sensing allosteric ribozymes with predefined oligonucleotide binding sites.
  europepmc 2026 置信度 0.80
• CEN-Display: Construction and optimization of a surface display system in Saccharomyces cerevisiae CEN.PK2-1C.
  europepmc 2026 置信度 0.80
• Inactivation of P450 Reprograms the Ring Topology of Glycopeptide Antibiotics.
  europepmc 2026 置信度 0.80
• Deep eutectic solvent modified metal-organic framework for [NiFe] hydrogenase biomimetic immobilization with enhanced oxygen tolerance.
  europepmc 2026 置信度 0.80
• An Experimentally Verified Mechanistic Model for Predicting Quorum Sensing-Based Switches.
  Quorum sensing-based genetic circuits are gaining traction in synthetic biology as they link population-level behaviour to individual cell responses. However, tuning these circuits remains challenging due to complex dynamics, particularly during the 'Learn' ph…
  europepmc 2026 置信度 0.80
• TimeVault: a synthetic time capsule for transcriptome storage.
  europepmc 2026 置信度 0.80
• Endosperm-specific expression of Zizania latifolia ZlRc and ZlMYB1 enriches flavonoids in rice endosperm.
  europepmc 2026 置信度 0.80
• Flip-Flow bioreactors enhance bioproductions with better oxygen transfer and energy saving.
  A flip-flow bioreactor featuring clock- and counter-clockwise stirring was used to enhance oxygen transfer efficiency and mixing performance for high-density aerobic cell growth. Computational fluid dynamics (CFD) simulations demonstrated that bidirectional st…
  pubmed Zhang G, Tang MT, Li C, Liu Y 等 2026 置信度 0.82
• Fine-tuned synthetic transcription factors for production of 3'-phosphoadenosine-5'-phosphosulfate in yeast.
  Background Technologies developed over the past decade have made Saccharomyces cerevisiae a promising platform for producing various natural products. Balancing multi-enzyme expression, while maintaining robust microbial growth, remains a limiting factor for e…
  europepmc 2026 置信度 0.80
• Antibiotic factories on the move: Synthetic bacteria survive drinking water treatment and continuously produce antibiotics.
  Synthetic biology enables the creation of high-yield synthetic antibiotic-producing bacteria (HYSAPB) for industrial biomanufacturing. However, HYSAPB may be inadvertently released into the environment. The fate of HYSAPB in natural water and subsequent the wh…
  pubmed Huang X, Xiu J, Liu T, Chen Y 等 2026 置信度 0.82
• Can Cells Be Fully Programmed and Engineered?
  Since its inception, synthetic biology has relied on linear genetic modifications to treat living cells as biological counterparts to silicon microchips and computer-aided manufacturing. This paradigm is deeply rooted in the historical frameworks of Turing, Bo…
  europepmc 2026 置信度 0.80
• Engineered bacterial siderophore production accelerates rock weathering for carbon removal.
  europepmc 2026 置信度 0.80
• Synthetic Biology and its Consequences in Present Healthcare
  crossref 2025-11-08T22:30:39Z 置信度 0.70
• Issue Editorial Masthead
  crossref 2026-08-22T16:21:58Z 置信度 0.70
• Issue Publication Information
  crossref 2026-08-22T16:21:58Z 置信度 0.70
• Copyright
  crossref 2026-05-29T12:09:26Z 置信度 0.70
• Index
  crossref 2026-05-29T12:09:26Z 置信度 0.70
• Dedication
  crossref 2025-11-08T11:00:56Z 置信度 0.70
• Copyright
  crossref 2025-11-08T11:00:56Z 置信度 0.70
• Acknowledgments
  crossref 2025-11-08T11:00:56Z 置信度 0.70
• Preface
  crossref 2025-11-08T11:00:56Z 置信度 0.70
• Synthetic Phage for the Evolution of Biomolecules
  crossref Gholamreza Abdi, Kirtan Dave, Saloni Gautam 2026-05-17T22:25:47Z 置信度 0.70
• Front Matter
  crossref 2026-05-29T12:09:26Z 置信度 0.70
• Contents
  crossref 2025-11-08T11:00:56Z 置信度 0.70
• Index
  crossref 2025-11-08T11:00:56Z 置信度 0.70
• About the editors
  crossref 2025-11-08T11:00:56Z 置信度 0.70
• Title page
  crossref 2025-11-08T11:00:56Z 置信度 0.70
• Synthetic biology integration
  crossref Sarfaraz Niazi 2026-08-14T16:28:40Z 置信度 0.70
• Synthetic Phage for the Detection of Cancer
  crossref Gauri Gaur, Ayush Seth, Palak Jain, Dhruv Kumar 2026-05-17T23:35:17Z 置信度 0.70
• Biosafety concerns and ethical aspects of synthetic biology
  crossref Krishan Kumar, Marwan Fakhri Abed, Arafat Ahmad, Hassan Youssef Hussein 等 2026-05-29T12:09:26Z 置信度 0.70
• Yeast Stress Response to Synthetic Constructs
  crossref Musa Tartik 2026-01-30T13:29:14Z 置信度 0.70
• Synthetic biology in galaxy
  Synthetic biology integrates biology and engineering, using advances in genomics and computational tools to design and reprogram living systems. However, the complex data analyses required can be a barrier for biologists without programming expertise. Galaxy, …
  crossref ramiz khaled, Jean-Loup Faulon, Joan Herisson 2026-08-04T07:17:08Z 置信度 0.70
• Minimal Cells
  crossref Karan Murjani, Vijai Singh 2026-05-17T22:44:43Z 置信度 0.70
• Application of synthetic biology in novel drug delivery system
  crossref Rajdip Goswami, Saikat Santra, Meghamouli Rana, Bhaskar Pal 等 2025-11-08T11:00:56Z 置信度 0.70
• Application of synthetic biology in mammalian cell-based therapies and cancer
  crossref Krishnendu Adhikary, Riya Dey, Prity Chatterjee, Sucheta Chatterjee 等 2025-11-08T11:00:56Z 置信度 0.70
• Synthetic Biology And The Rise Of Programmable Medicine
  crossref Obi Blessing Obi 2026-01-30T12:43:37Z 置信度 0.70
• Gene and Genome Assembly
  crossref Slavil Peykov, Boris Kirov 2026-05-17T22:41:15Z 置信度 0.70
• Ethical issues of synthetic biology research, development and application. Reports of the IBC series
  Synthetic biology and its applications are fundamentally redefining a wide range of sectors, ranging from agriculture to human health. Despite low public awareness of its evolution, this field is already reshaping our societies in profound ways. With the adven…
  crossref 2026-04-23T08:53:57Z 置信度 0.70
• Synthetic Biology–Driven Innovation in the Production of Cosmetic Ingredients: From Natural Mimicry to Precision Creation
  crossref Yi Jinhang, Zhang Mengxi, Hu Fangying, Wu Heyun 等 2026-03-02T05:39:25Z 置信度 0.70
• The Synthetic Biology of Music
  Abstract This chapter introduces the synthetic biology of music, understood as the modeling and simulation of biological processes relevant to music and musicality using computers. It begins by expanding the scope of the evolutionary algorithm to domains other…
  crossref Steven Jan, Robin Laney 2026-07-07T21:01:18Z 置信度 0.70
• Complex-phase stochastic modeling of mitochondrial heteroplasmy
  Annotation Mitochondrial heteroplasmy —the coexistence of both wild-type and mutant copies of mitochondrial DNA (mtDNA) within a cell—is a key factor in the pathogenesis of mitochondrial diseases. Classical approaches, which rely solely on the scalar fraction …
  crossref S.D. Nurbaev, E.A. Pocheshkhova 2026-06-09T14:10:13Z 置信度 0.70
• Design and Characterization of the Synthetic Microbial Genome
  crossref Nomthandazo Twala, Mutsa M. Takundwa, Earl Prinsloo, Deepak B. Thimiri Govinda Raj 2026-05-17T22:25:16Z 置信度 0.70
• Issue Publication Information
  crossref 2026-03-20T07:21:55Z 置信度 0.70
• Issue Editorial Masthead
  crossref 2026-05-15T07:27:57Z 置信度 0.70
• Issue Publication Information
  crossref 2026-07-17T12:55:41Z 置信度 0.70
• Issue Editorial Masthead
  crossref 2026-04-17T07:26:08Z 置信度 0.70
• Issue Publication Information
  crossref 2026-02-20T08:30:26Z 置信度 0.70