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• SYNTHETIC BIOLOGY STRATEGIES FOR DRUG DISCOVERY
  The landscape of pharmaceutical research is undergoing a fundamental shift driven by the integration of synthetic biology (SB). Rather than relying solely on traditional chemical synthesis or the direct extraction of natural products, this discipline treats bi…
  datacite Meher N. Tamboli*, Ms. Kalyani J. Bhor, Hemlata S. Pingat, Rajshree V. Satpute, Nutan M. Shinde 2026 置信度 0.66
• The Role of Biologics and Bone Graft Substitutes in Spinal Fusion: Current Evidence and Future Directions
  Successful spinal arthrodesis requires a biologically active environment, mechanical stability, and sufficient graft material. Autologous iliac crest bone remains the reference standard because it provides osteogenic cells, osteoinductive signals, and an osteo…
  datacite Muhammad Hamza Mubarak, Mubarak Ali, Muhammad Hammad Mubarak 2026 置信度 0.66 spinal fusion, osteobiologics, bone graft substitute, bone morphogenetic protein, demineralized bone matrix, cellular bone matrix, ceramics
• The Role of Biologics and Bone Graft Substitutes in Spinal Fusion: Current Evidence and Future Directions
  Successful spinal arthrodesis requires a biologically active environment, mechanical stability, and sufficient graft material. Autologous iliac crest bone remains the reference standard because it provides osteogenic cells, osteoinductive signals, and an osteo…
  datacite Muhammad Hamza Mubarak, Mubarak Ali, Muhammad Hammad Mubarak 2026 置信度 0.66 spinal fusion, osteobiologics, bone graft substitute, bone morphogenetic protein, demineralized bone matrix, cellular bone matrix, ceramics
• Modern Biotechnology Approaches to Address Food Security Challenges
  Abstract Global food security remains one of the most pressing challenges of the 21st century due to rapid population growth, climate change, declining arable land, and emerging biotic and abiotic stresses. Modern biotechnology offers innovative and sustainabl…
  datacite Supriya, Nelaturi, Duganapalli, Manisha, P. Hanok Santha Raju, Sekhar, P. Ravi 等 2026 置信度 0.66 Biotechnology; Food Security; CRISPR/Cas9; Genetically Modified Crops; Biofortification; Climate Change; Sustainable Agriculture; Genome Editing; Crop Improvement; Agricultural Innovation
• Modern Biotechnology Approaches to Address Food Security Challenges
  Abstract Global food security remains one of the most pressing challenges of the 21st century due to rapid population growth, climate change, declining arable land, and emerging biotic and abiotic stresses. Modern biotechnology offers innovative and sustainabl…
  datacite Supriya, Nelaturi, Duganapalli, Manisha, P. Hanok Santha Raju, Sekhar, P. Ravi 等 2026 置信度 0.66 Biotechnology; Food Security; CRISPR/Cas9; Genetically Modified Crops; Biofortification; Climate Change; Sustainable Agriculture; Genome Editing; Crop Improvement; Agricultural Innovation
• Engineered Exosomes for Neurological Disorders: From Biomarkers to Brain-Targeted Drug Delivery and Clinical Translation
  Neurological disorders, including Alzheimer’s disease, Parkinson’s disease, glioblastoma, ischemic stroke, multiple sclerosis, amyotrophic lateral sclerosis, Huntington’s disease, traumatic brain injury, and spinal cord injury, remain major causes of mortality…
  datacite Yash Kothikar*, Tanveer Patel 2026 置信度 0.66 Engineered exosomes; Neurological disorders; Blood–brain barrier; Brain-targeted drug delivery; Extracellular vesicles; Nanomedicine
• Engineered Exosomes for Neurological Disorders: From Biomarkers to Brain-Targeted Drug Delivery and Clinical Translation
  Neurological disorders, including Alzheimer’s disease, Parkinson’s disease, glioblastoma, ischemic stroke, multiple sclerosis, amyotrophic lateral sclerosis, Huntington’s disease, traumatic brain injury, and spinal cord injury, remain major causes of mortality…
  datacite Yash Kothikar*, Tanveer Patel 2026 置信度 0.66 Engineered exosomes; Neurological disorders; Blood–brain barrier; Brain-targeted drug delivery; Extracellular vesicles; Nanomedicine
• Advanced Metabolic Engineering Strategies for Developing Microbial Cell Factories
  This extensive technical review provides a detailed roadmap for the development and optimization of microbial cell factories through advanced systems metabolic engineering. Microbial cell factories are engineered microorganisms designed to sustainably convert …
  datacite metabolic engineering 2026 置信度 0.66 Microbial Cell FactoriesMetabolic EngineeringSynthetic BiologyCRISPR-Cas9Genome-Scale Metabolic Models
• Advanced Metabolic Engineering Strategies for Developing Microbial Cell Factories
  This extensive technical review provides a detailed roadmap for the development and optimization of microbial cell factories through advanced systems metabolic engineering. Microbial cell factories are engineered microorganisms designed to sustainably convert …
  datacite metabolic engineering 2026 置信度 0.66 Microbial Cell FactoriesMetabolic EngineeringSynthetic BiologyCRISPR-Cas9Genome-Scale Metabolic Models
• Tutorial: biomembranes in hybrid living bioelectronics.
  The integration of biological and artificial systems promises the effective coupling of living cells with electronic devices. However, to create biomimetic platforms capable of bridging biological with artificial systems, it is necessary to first enhance cell …
  datacite Hattar, Alice, Alhammadi, Jawaher, Treiber, Jeremy, Hoven, Darius 等 2026 置信度 0.66 3101 Biochemistry and Cell Biology40 Engineering31 Biological Sciences4003 Biomedical EngineeringBioengineering
• BioSym: A Theoretical Framework for Photosynthetic Symbiotic Assistant Blood Cells as a Platform for Endogenous Human Enhancement
  BioSym, a speculative theoretical framework for the design of a novel class of endogenous biological agents, Photosynthetic Symbiotic Assistant Cells (PSACs); intended to function as a fourth blood cell lineage. Inspired by three converging scientific advances…
  datacite Panta, Prabin 2026 置信度 0.66 PhotosynthesisSynthetic BiologyendosymbiosisHematopoietic Stem CellsBiomedical Enhancement
• BioSym: A Theoretical Framework for Photosynthetic Symbiotic Assistant Blood Cells as a Platform for Endogenous Human Enhancement
  BioSym, a speculative theoretical framework for the design of a novel class of endogenous biological agents, Photosynthetic Symbiotic Assistant Cells (PSACs); intended to function as a fourth blood cell lineage. Inspired by three converging scientific advances…
  datacite Panta, Prabin 2026 置信度 0.66 PhotosynthesisSynthetic BiologyendosymbiosisHematopoietic Stem CellsBiomedical Enhancement
• Expanding the genetic programmability of Lactiplantibacillus plantarum
  Lactobacilli are ubiquitous in nature and symbiotically provide health benefits for countless organisms including humans, animals and plants. They are vital for the fermented food industry and are being extensively explored for healthcare applications. For all…
  datacite Blanch‐Asensio, Marc, Dey, Sourik, Tadimarri, Varun Sai, Sankaran, Shrikrishnan 2024 置信度 0.66 570610
• From Latent Symbols to Molecular Processors: Ribosomic Dictionary Nano-Translation System (The RDNT System)
  This preprint introduces the Ribosomic Dictionary Nano-Translation System (RDNT System), a falsifiable research program exploring whether artificial intelligence inference can be cognitively decoupled, compressed into discrete, compositional codes, and execute…
  datacite Darkwood, David A., Wyatt, K. L. W. 2026 置信度 0.66 Artificial intelligenceGenerative artificial intelligenceDNA computingMolecular computingBiocomputing
• From Latent Symbols to Molecular Processors: Ribosomic Dictionary Nano-Translation System (The RDNT System)
  This preprint introduces the Ribosomic Dictionary Nano-Translation System (RDNT System), a falsifiable research program exploring whether artificial intelligence inference can be cognitively decoupled, compressed into discrete, compositional codes, and execute…
  datacite Darkwood, David A., Wyatt, K. L. W. 2026 置信度 0.66 Artificial intelligenceGenerative artificial intelligenceDNA computingMolecular computingBiocomputing
• Strengthening the Biological Weapons Convention in an Era of Emerging Biotechnologies
  This monograph advances an original analytical framework—the Four Pillars Governance Framework—for understanding the Biological Weapons Convention (BWC) as an evolving international governance regime rather than solely as a classical arms-control treaty. The f…
  datacite Okafor, Ikenna C. 2026 置信度 0.66 Biological GovernanceScience DiplomacyArticle XImplementation Support UnitReview Conference
• Strengthening the Biological Weapons Convention in an Era of Emerging Biotechnologies
  This monograph advances an original analytical framework—the Four Pillars Governance Framework—for understanding the Biological Weapons Convention (BWC) as an evolving international governance regime rather than solely as a classical arms-control treaty. The f…
  datacite Okafor, Ikenna C. 2026 置信度 0.66 Biological GovernanceScience DiplomacyArticle XImplementation Support UnitReview Conference
• Filtering Using Chemistry for Self-Continuation: An Observable Pattern Distinguishing Living Systems.
  This paper identifies an observable pattern that distinguishes living systems: Filtering Using Chemistry for Self-Continuation. Classical biology highlights hallmarks such as metabolism, signaling, homeostasis, and reproduction (Alberts et al., 2014). We show …
  datacite Shadi, David 2026 置信度 0.66
• Filtering Using Chemistry for Self-Continuation: An Observable Pattern Distinguishing Living Systems.
  This paper identifies an observable pattern that distinguishes living systems: Filtering Using Chemistry for Self-Continuation. Classical biology highlights hallmarks such as metabolism, signaling, homeostasis, and reproduction (Alberts et al., 2014). We show …
  datacite Shadi, David 2026 置信度 0.66
• Food Waste Valorization: Converting Agro-Industrial By-Products into Value-Added Products
  preprints 2026 置信度 0.74
• Gallic Acid Bioproduction: From Tannin Hydrolysis to de Novo Biosynthesis by Engineered Microbial Cell Factories
  Gallic acid (GA) is a value-added phenolic compound widely applied in the food, pharmaceutical, and cosmetic industries. Traditionally obtained through chemical hydrolysis of tannins, its production faces limitations related to environmental impact, substrate …
  preprints 2026 置信度 0.74
• The Biological Limits of microRNA Therapeutics: Lessons from Preclinical and Clinical Studies
  preprints 2026 置信度 0.74
• bHLH Family Transcription Factors: Molecular Switches for Plant Specialized Metabolism
  preprints 2026 置信度 0.74
• Microbial α-L-Rhamnosidases: Regioselective Biocatalysts for Flavonoid Biotransformation and Nutraceuticals Applications
  preprints 2026 置信度 0.74
• Human Neutrophil Elastase and the Protein-Storm Axis: Reversible Synthetic Inhibitors in Inflammatory Disease
  preprints 2026 置信度 0.74
• Evaluating AI-Assisted Customer Verification for Synthetic Nucleic Acid Screening
  Abstract Legitimacy screening, the process of verifying the identity and purpose of customers ordering synthetic nucleic acids, is a primary safeguard against the misuse of synthetic biology. However, the associated costs discourage the adoption of screening p…
  preprints Alejandro Acelas, Hanna Pálya, Kevin Flyangolts, Paul-Enguerrand Fady 等 2026 置信度 0.74
• Is the CHEK2 Gene Able to Offer Platinum Sensitivity Despite Low Variant Allele Frequency? A Case Report and Review in Literature
  preprints 2026 置信度 0.74
• Integrated Bioremediation Approaches for Air, Soil, and Water Pollution: From Microbial Consortia to Engineered Systems (2015–2026): A Review
  preprints 2026 置信度 0.74
• Engineering an Enhanced E. coli Copper Biosensor
  Abstract Excess copper from industrial and agricultural sources poses serious environmental and health risks, necessitating field-deployable detection methods. Here we present a comprehensive redesign and systematic benchmarking of a whole-cell Escherichia col…
  preprints 2026 置信度 0.74
• From Gene Editing to Environmental Cleanup: Bridging Advanced rDNA and Biotechnology with Bioremediation and Bioethical Governance: A Review
  preprints 2026 置信度 0.74
• Rigid Adamantane and Cubane Scaffolds in Chemical Biology and Medicine
  preprints 2026 置信度 0.74
• Synergistic Integration of Enzyme and Microbial Platforms for Sustainable Management of Pharmaceutical Pollutants: Towards a Greener Pharmaceutical Lifecycle
  preprints 2026 置信度 0.74
• The Mevalonate Pathway: Characteristics, Innovations, Applications, and Challenges in Biotechnology
  preprints 2026 置信度 0.74
• Diffusion-Controlled Therapeutic Delivery via Engineered Bacterial Biofilm Scaffolds in Oncology
  preprints 2026 置信度 0.74
• Substrate dependent microalgal biofilm cultivation system for the blue and green economy: formation, mechanism, and applications in environmental engineering and biotechnology
  preprints 2026 置信度 0.74
• <p class="MDPI12titleori1" style="mso-line-height-alt: 14.0pt;">Photo-Oxidative Stress in Plants: Molecular Mechanisms, Damage, and Adaptive Strategies for Resilience
  preprints 2026 置信度 0.74
• Precise kinematic and muscle recording in freely behaving flies enabled by closed-loop tracking and annotation-free pose estimation
  Understanding the neuromuscular basis for behavior requires measuring both kinematic and physiological data at high resolution in unconstrained conditions: a technically challenging goal. Here we present an integrated experimental-computational pipeline for me…
  preprints 2026 置信度 0.74
• Self-propagating organelle biogenesis on synthetic beads
  preprints 2026 置信度 0.74
• Hollow-fibre biomanufacturing and cell-free engineering of HEK293 extracellular vesicles
  preprints 2025 置信度 0.74
• Probabilistic Calibration of a Closed-loop Cardiac Electromechanical Model with Application to Cardiac Resynchronization Therapy
  preprints 2026 置信度 0.74
• Biotechnological Interventions in Enhancing Secondary Metabolites from Medicinal Plants: A Review
  preprints 2025 置信度 0.74
• Controlled Delivery and Light-Induced Release of Magic Spot Nucleotides in <i>Escherichia coli</i>
  preprints 2025 置信度 0.74
• Microbiome-Guided Precision Medicine: Mechanistic Insights, Multi-Omics Integration, and Translational Horizons
  preprints 2025 置信度 0.74
• CNS Myelin Sheath Lengths Locally Scale to Axon Diameter via Piezo1
  preprints 2025 置信度 0.74
• Engineered <em>Escherichia coli </em>Strains as Therapeutic Agents in Reactive Oxygen Species (ROS)-Mediated Glioblastoma Treatment: A Systematic Review of Mechanisms, Efficacy, and Challenges
  Glioblastoma multiforme (GBM) remains one of the most aggressive and treatment-resistant brain tumors, characterized by a hostile microenvironment and poor prognosis. Recent advances in synthetic biology have led to the engineering of Escherichia coli (E. coli…
  preprints 2025 置信度 0.74
• Mastering the Genome: The Evolving Landscape of Precise DNA Insertion in Plants
  preprints 2025 置信度 0.74
• Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition
  Mutations in the adenomatous polyposis coli (APC) gene are a defining feature of colorectal cancer (CRC) and impose metabolic and stress-adaptation requirements that may create exploitable vulnerabilities. Prolyl hydroxylase domain (PHD) inhibitors have been e…
  preprints 2026 置信度 0.74
• ExTaSy: A swappable CRISPR platform for endogenous tagging in <i>Drosophila melanogaster</i>
  preprints 2026 置信度 0.74
• TIGR-Tas and the Expanding Universe of RNA-Guided Genome Editing Systems: A New Era Beyond CRISPR-Cas
  preprints 2025 置信度 0.74
• ImmTACs overcome cytotoxic T cell suppression
  preprints 2026 置信度 0.74
• Synthetic lumen rounding directs neural progenitor division mode
  Abstract Although function often follows form, the causal role of tissue geometry is difficult to disentangle in complex embryonic development. Brain organoids generated using diverse protocols and species display striking morphological variability, particular…
  preprints Marina Marchenko, Guillermo Martínez Ara, Juslina Pulikkal, Keisuke Ishihara 等 2026 置信度 0.74
• Organization and triggered release of liposomes with DNA-based synthetic condensates
  preprints 2025 置信度 0.74
• A Roadmap to Exploiting Biocementation for Martian Construction: Pathways, Challenges, and Research Gaps
  preprints 2025 置信度 0.74
• GeneScanner: profiling genetic variation across bacterial populations
  preprints 2025 置信度 0.74
• CRISPR as a next-generation environmental biosurveillance tool for air, land and water
  preprints 2025 置信度 0.74
• The Androgen Receptor and MYC synergise to modulate the synthesis of Siglec-7 ligands in prostate cancer
  preprints 2025 置信度 0.74
• Host and microbial factors influence bacterial colonization of the honey bee gut
  preprints 2025 置信度 0.74
• A specialized ARGONAUTE enables trans-species RNA interference in plant immunity
  preprints 2026 置信度 0.74
• Reliable repurposing of antibody interactome inside the cell
  preprints 2025 置信度 0.74
• Ca2+ signature gates early auxin signaling in Arabidopsis roots
  Plants must continually balance growth with arrest, especially under stress. Auxin signaling acts as a central regulatory hub in this process, yet the mechanisms that dynamically tune early auxin signalling in real time remain unknown. Here, we used the light-…
  preprints 2025 置信度 0.74
• Programmable DNA Devices: The Next Generation of Living Sensors in Agriculture, Health, and the Environment
  Programmable DNA devices represent a transformative frontier in biosensing technology, offering unprecedented precision, adaptability, and miniaturization. These devices—ranging from DNA nanostructures and aptamer-based sensors to gene circuits and DNA strand …
  preprints 2025 置信度 0.74
• Blockade of the KRAS-FOSL1 axis elicits DNA damage repair deficiency exploitable with local and systemic genotoxic therapies
  Abstract The clinical approval of direct KRAS inhibitors represents a milestone in precision oncology. Nonetheless, resistance heterogeneity limits durable clinical responses and impedes the nomination of a ‘‘one-size-fits-all’’ strategy for combination therap…
  preprints 2026 置信度 0.74
• Alternative exon splicing reveals hidden mitochondrial targeting of PLIN3
  preprints 2026 置信度 0.74
• QuantGUV: Quantifying Encapsulation Efficiency of Small Molecules in GUVs
  1 Synthetic cells, constructed through the self-assembly of small molecules, are designed to mimic life-like behaviours by encapsulating functional molecules. For such synthetic cells to accurately replicate cellular reactions, it is critical that the concentr…
  preprints 2025 置信度 0.74
• The sequence context of RG/RGG motifs determines condensate formation, transportin-1 binding and chaperoning
  preprints 2026 置信度 0.74
• ATM safeguards DNA replication at endogenous base lesions
  preprints 2026 置信度 0.74
• Origin of chaperone dependence and assembly complexity in Rubisco’s biogenesis
  preprints 2025 置信度 0.74
• ProteoCast: a web server to predict, validate, and interpret missense variant effects
  preprints 2025 置信度 0.74
• Federated analysis of incubation period distributions using individual-level observed data and heterogeneous summary statistics
  preprints 2026 置信度 0.74
• Condensate-based shells and scaffolds via interfacial liquid-to-solid transition of disordered peptides
  Living organisms use biomolecular condensates to respond to dynamic environments and create functional materials with complex architectures. Exploring such phase-separated systems beyond the naturally occurring scenarios may offer valuable insights for emergen…
  preprints 2025 置信度 0.74
• Structure, Function, and Regulation of LytA: The N-Acetylmuramoyl-L-alanine Amidase Driving the ‘Suicidal Tendencies’ of Streptococcus pneumoniae— A Review
  preprints 2025 置信度 0.74
• Beyond alignment: synergistic integration is required for multimodal cell foundation models
  preprints 2026 置信度 0.74
• Sni445 recruits box C/D snoRNPs snR4 and snR45 to guide ribosomal RNA acetylation by Kre33
  preprints 2025 置信度 0.74
• Personalized Whole-Brain Models of Seizure Propagation
  preprints 2025 置信度 0.74
• Eggerthella lenta evades bacteriophage through reversible megabase-scale inversions of capsular polysaccharide gene clusters
  Abstract Bacteriophages are a promising tool for microbiome editing, yet their development has been constrained by limited insights into bacteriophage-host interactions within their shared mammalian body habitat. We isolated a lytic phage ΦKL11 that efficientl…
  preprints 2026 置信度 0.74
• A hierarchical nickel organic framework confers high conductivity over long distances in cable bacteria
  preprints 2025 置信度 0.74
• MAGELLAN: Automated Generation of Interpretable Computational Models for Biological Reasoning
  Computational models have become essential tools for understanding signalling networks and their non-linear dynamics. However, these models are typically constructed manually using prior knowledge and can be over-reliant on study bias. These limitations hinder…
  preprints 2025 置信度 0.74
• Understanding neural circuit principles for representation learning through joint-embedding predictive architectures
  Tracking prey or recognizing a lurking predator is as crucial for survival as anticipating their actions. To guide behavior, the brain must extract information about object identities and their dynamics from entangled sensory inputs. How it accomplishes this f…
  preprints 2025 置信度 0.74
• Archaeal histone HTkC hypercompacts DNA
  preprints 2025 置信度 0.74
• Protein structure shapes natural genetic variation and <i>de novo</i> adaptation
  Protein structural context strongly influences the functional outcomes of mutations, but exploiting this intuition to interpret the consequences of natural variants has been limited by the paucity of structural information. Here, we show that simple molecular …
  preprints 2025 置信度 0.74
• Engineered hematopoietic stem cells give rise to therapeutic antibody secreting B cells
  preprints 2026 置信度 0.74
• Identification of Dynamic Genetic Influences on DNA Methylation from Birth to Adulthood
  Whether and how genetic regulation of DNA methylation (DNAm) change across the lifespan remains unclear. Here, we map age-dependent methylation quantitative trait loci (longitudinal mQTLs) using linear mixed models applied to repeated blood DNAm measures from …
  preprints 2026 置信度 0.74
• Ligand-regulated ACKR3 nanoclustering shapes CXCR4 signaling at the plasma membrane
  preprints 2026 置信度 0.74
• Activation-independent capture of free fatty acids at the bacterial cell envelope by BrtB
  preprints 2026 置信度 0.74
• Gene syntax defines supercoiling-mediated transcriptional feedback
  Gene syntax—the order and arrangement of genes and their regulatory elements—shapes the dynamic coordination of both natural and synthetic gene circuits. Transcription at one locus profoundly impacts the transcription of nearby adjacent genes, but the molecula…
  preprints 2025 置信度 0.74
• Genome-wide association and multi-omics functional screens reveal the genetic architecture of foveal development
  preprints 2026 置信度 0.74
• Aim11 is a novel protein involved in the assembly of mitochondrial cytochrome <i>c</i> oxidase
  preprints 2025 置信度 0.74
• Inter- and intra-individual differences in brain sex map to neuroendocrine profiles
  preprints 2025 置信度 0.74
• PRMix: Primary Region Mix Augmentation and Benchmark Dataset for Precise Whole Mouse Brain Anatomical Delineation
  preprints 2025 置信度 0.74
• In situ programming of intratumoural stem cell-like memory CD8⁺ T cells enables durable antitumour immunity in immunosuppressive tumours
  preprints 2026 置信度 0.74
• Challenges and Opportunities for New Frontiers and Technologies to Guarantee Food Production: A Broad Systematic Perspective
  The global food production sector faces unprecedented challenges due to rapid population growth and escalating climate change impacts, necessitating innovative strategies to ensure food security and promote sustainability. This comprehensive review explores cu…
  preprints 2025 置信度 0.74
• Open EGGbox: an open-source 3D-printed embryonic <i>Gallus gallus</i> toolbox for electroporation and culture/live imaging of avian embryos <i>ex ovo</i>
  preprints 2025 置信度 0.74
• Engineering N-acyl-homoserine lactone-based quorum-sensing circuit for dynamic regulatory control in Saccharomyces cerevisiae
  Abstract The yeast Saccharomyces cerevisiae is widely employed in industrial biotechnology for chemical and pharmaceutical production. However, engineering yeast for high product titers remains challenging due to metabolic imbalances and competition for cellul…
  preprints 2025 置信度 0.74
• 3D atomic structure reveals evolution of prions in templated amplification in vitro
  preprints 2026 置信度 0.74
• Biome-specific genome catalogues reveal functional potential of shallow sequencing
  The use of 16S rRNA metabarcoding for functional prediction is limited by several biases. Shallow shotgun sequencing is a cost-effective and taxonomically high-resolution alternative to 16S rRNA metabarcoding, but the low sequencing depth limits functional inf…
  preprints 2025 置信度 0.74
• Systematic comparison of estimates of transcription factor activity by ATAC-seq and multiplexed reporter assays
  ABSTRACT Transcription factors (TFs) are central to gene regulation and play critical roles in development, cellular homeostasis and disease. The ability to accurately measure TF activity is essential to understanding how TFs respond to signals and regulate ta…
  preprints 2026 置信度 0.74
• Preclinical efficacy of a systemically-administered, second-generation STING agonist that promotes antitumour immunity in combination with radiotherapy
  As potent triggers of innate immunity, STING agonists hold promise as active immunotherapeutic agents for cancer treatment. Second-generation STING agonists, suitable for systemic delivery, are being investigated in preclinical research and have entered clinic…
  preprints 2026 置信度 0.74
• Evolutionary selection of DNA nanostructures for cellular uptake
  preprints 2026 置信度 0.74
• Proteogenomic origins of disease in British South Asians
  Proteogenomic studies have transformed the way we derive novel insights into human biology and pathophysiology but are currently limited by their proteomic coverage and ancestral representation. Here, we integrate rare and common genetic variation with measure…
  preprints 2026 置信度 0.74
• Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity
  preprints 2025 置信度 0.74