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• Engineering an Artificial Taxol Biosynthetic Pathway from Baccatin III in Yeast.
  europepmc 2026 置信度 0.80
• Design guide for synthetic small regulatory RNAs for high-efficiency gene knockdown in bacteria.
  europepmc 2026 置信度 0.80
• Responsible biotechnology: an analysis of the Asilomar 2025 entreaties.
  Fifty years after the original Asilomar Meeting on Recombinant DNA, new stakeholders in biotechnology reconvened at the Spirit of Asilomar and Future of Biotechnology 2025 Conference. The objective was the responsible advancement of biotechnology, with open-en…
  pubmed Chemla Y, Voigt CA 2026 置信度 0.82
• Engineering Protease-Resistant Peptides via Non-Canonical Amino Acids: Design Strategies and Biosynthetic Advances.
  Peptide therapeutics offer high target selectivity and low toxicity, but their clinical utility remains constrained by rapid proteolysis in vivo and negligible oral bioavailability. Incorporating non-canonical amino acids (ncAAs) provides a robust molecular en…
  pubmed Deng C, Fan Z, Xu Y, Cao M 等 2026 置信度 0.82
• Denuded peptidoglycan oligosaccharides enable the biochemical investigation of bacterial cell wall recognition, modification, and degradation.
  Peptidoglycan is an essential component of the bacterial cell wall, providing mechanical strength and maintaining cell shape. It consists of glycan chains crosslinked by short peptide stems, resulting in a chemically heterogeneous macromolecule that remains ch…
  pubmed Emmanuel BG, DelMistro G, Anderson AC, Vandenende C 等 2026 置信度 0.82
• Restoring intracellular homeostasis disrupted by synthetic nanoassemblies.
  europepmc 2026 置信度 0.80
• Global Probiotic Markets Meet Synthetic Biology: Translational Challenges and <i>Escherichia coli</i> Nissle 1917 as a Model Chassis.
  The global probiotic market is expanding rapidly, driven by growing demand for accessible strategies to support gut health, preventive care, and microbiome-based interventions. However, this commercial growth contrasts with the limited number of clinically val…
  pubmed Chen J, Chou CP, Liu Y 2026 置信度 0.82
• Harnessing computational intelligence for synthetic lethality: A roadmap from network biology to interpretable deep learning in precision oncology.
  europepmc 2026 置信度 0.80
• microRNA-mediated control of cell fate specification and patterning in Marchantia polymorpha.
  MicroRNAs (miRNAs) are small non-coding RNA molecules essential for growth and development in eukaryotes. In plants, the master gene DICER-LIKE 1 (DCL1) catalyzes the biogenesis of miRNAs by processing double-stranded precursors that give rise to mature miRNAs…
  pubmed Aguilar-Cruz A, Flores-Sandoval E, Xu Y, Yu Y 等 2026 置信度 0.82
• Copper-Catalyzed SN2'-Type Allylic Substitution of gem-Dichlorocyclobutenones with Cyclopropanols.
  Both gem-dichlorocyclobutenones and cyclopropanols are versatile building blocks in organic synthesis. Herein, we report a Cu/dppp-catalyzed SN2'-type allylic substitution of gem-dichlorocyclobutenones with cyclopropanols. The reaction proceeds smoothly via a …
  pubmed Liu MM, An XD, Wang JF, Tian P 等 2026 置信度 0.82
• Fuel-Driven Coacervates: Design Principles, Dissipative Dynamics, and Life-like Functions.
  Living systems operate far from equilibrium, continuously consuming energy to maintain transient functional compartments. Mimicking such dynamic organization through bottom-up self-assembly remains a central challenge in systems chemistry and synthetic biology…
  pubmed Srivastava A, Maity A, Kumar P, Rana S 2026 置信度 0.82
• Online Raman spectroscopy-guided strategy for efficient production of DNA recombinase UvsX in Escherichia coli.
  europepmc 2026 置信度 0.80
• Emerging synthetic biology-assisted technologies for overcoming antibiotic resistance: CRISPR-Cas, bacteriophage, microbiome, and metabolic engineering-based solutions.
  europepmc 2026 置信度 0.80
• An advanced genome engineering platform for Komagataella phaffii enabling versatile in vivo DNA assembly and multiplex integration.
  The transition toward a sustainable bioeconomy necessitates the development of robust microbial platforms capable of C1 chemical valorization, particularly the conversion of methanol into high-value chemicals. Komagataella phaffii is a premier methylotrophic h…
  pubmed Choi Y, Kim A, Kang NK 2026 置信度 0.82
• Corrigendum to "Evaluation of molecular mechanisms of (Z)-3-(pentadec-10'-enyl)-catechol (litreol) and synthetic derivatives as inhibitors of human leukotriene biosynthesis" [Redox Biol. 87 (2025) 103880].
  europepmc 2026 置信度 0.80
• Post-Synthetic Modification of the C═C Linkage in a Vinylene-Linked COF for ROS-Mediated Enamine Dimerization.
  europepmc 2026 置信度 0.80
• Amelioration of obesity-induced endothelial dysfunction by a synthetic ocean-derived peptide via regulating PPARα/γ pathway.
  europepmc 2026 置信度 0.80
• Rapid and Continuous Directed Evolution in <i>Vibrio natriegens</i> Utilizing an <i>In Vivo</i> Hypermutation System.
  europepmc 2026 置信度 0.80
• Emerging Precision Therapeutic Strategies in Pancreatic Ductal Adenocarcinoma: KRAS Targeting, DDR Vulnerabilities, Immune Redirection, and Tumor Microenvironment Remodeling.
  europepmc 2026 置信度 0.80
• Protein-Primed DNA Replication is Restored in a Modified Cell-Free Protein Synthesis System.
  europepmc 2026 置信度 0.80
• Highly selective enrichment of multi-phosphopeptides by polyurea-modified macroporous adsorption resin via hydrogen-bond-mediated interaction.
  europepmc 2026 置信度 0.80
• Fungal polyketide biosynthesis as a platform for designer natural products.
  europepmc 2026 置信度 0.80
• Repurposing the TIGR-Tas system for programmable transcription activation
  europepmc 2026 置信度 0.80
• Sex hormone-binding globulin as a context-dependent regulator of sex steroid bioavailability in cancers.
  europepmc 2026 置信度 0.80
• Chemoenzymatic Synthesis of 6-Sulfo Lewis X-Related Glycans for Probing Their Ligand-Binding Proteins.
  europepmc 2026 置信度 0.80
• Chemical Biology 2025: Highlights From the Ch/Bi145 Course at Caltech.
  This review highlights key advances in chemical biology reported in 2025, curated by students in the Advanced Chemical Biology course (Ch/Bi145) at the California Institute of Technology (Caltech). The selected studies span advances in bioconjugation and bioor…
  pubmed Ashton-Rickardt GP, Chung DK, Corman SA, Gilbert MS 等 2026 置信度 0.82
• Allergen Protease Act d 1 Induces TLR4-Dependent Inflammation via Ectodomain Cleavage.
  europepmc 2026 置信度 0.80
• Programmable nanomedicine via bioorthogonal molecular engineering.
  Bioorthogonal chemistry provides a versatile strategy for programming nanomedicines beyond static carrier design. It enables post-synthetic installation of functional modules on nanoparticle surfaces, spatiotemporal control of payload activation and release, a…
  pubmed Im S, Koo S, Kim JS 2026 置信度 0.82
• Icariin: Unraveling Ferroptosis Mechanisms, Metabolic Networks, and Innovative Therapy Strategies.
  europepmc 2026 置信度 0.80
• DNA Damage Recognition by Bacterial and Human Adenine-DNA Glycosylases: Insights from Non-Canonical Substrates.
  europepmc 2026 置信度 0.80
• Tandem Duplication-Driven Neofunctionalization of UDP-Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae.
  europepmc 2026 置信度 0.80
• RNA biosensors in oncology: Mechanisms, Cancer-specific applications, and a Hallmark-aligned clinical roadmap.
  europepmc 2026 置信度 0.80
• In vitro evaluation of phage cocktail efficiency against multiple aquaculture bacterial pathogens.
  europepmc 2026 置信度 0.80
• Corazonin signaling, a molecular switch for ascovirus-mediated manipulation of host development and molting.
  europepmc 2026 置信度 0.80
• The rise and future of peptide-based antimicrobials.
  europepmc 2026 置信度 0.80
• A computational approach for the simultaneous generation of competing and optimized arterial trees based on hemodynamic principles.
  europepmc 2026 置信度 0.80
• Publisher Correction: Mammalian synthetic gene circuits for biopharmaceutical development & manufacture.
  Correction to: npj Systems Biology and Applications https://doi.org/10.1038/s41540-025-00621-y , published online 02 December 2025
  europepmc 2026 置信度 0.80
• Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis.
  Nutrient limitation is a characteristic feature of poorly perfused tumors. In contrast to well-perfused tissues, nutrient deficits in tumors impose metabolic constraints on cancer cells. The metabolic constraints created by the tumor microenvironment can lead …
  pubmed Jonker PB, Sadullozoda M, Cognet G, Apiz Saab JJ 等 2026 置信度 0.82
• Food-derived peptide RDP3 mitigates pyroptosis to enhance oral mucosal repair via the IL-2Rβ/PI3K axis.
  europepmc 2026 置信度 0.80
• Bacterial dynamin homolog regulates growth phase-dependent c-di-GMP production.
  europepmc 2026 置信度 0.80
• Comparative study of synthetic nanofilaments assembled from amphiphilic peptides and β-peptides as antigen delivery nanostructures.
  europepmc 2026 置信度 0.80
• Meeting Report on the Assisted Gene Flow and Climate Change Responses Workshop, Golden Gate National Recreation Area, CA, USA, 5-7 March 2025.
  europepmc 2026 置信度 0.80
• A Receptor-Mediated Endolysosomal Recycling Chimera Enables Catalytic TNF-α Degradation for Sustained Treatment of Mucosal Inflammation.
  europepmc 2026 置信度 0.80
• Editorial for the Special Issue "Microbial Solutions for Sustainable Resource Recovery and Environmental Remediation".
  europepmc 2026 置信度 0.80
• The bioproduction of prodigiosin: A comprehensive review on the microbial biosynthesis, regulatory mechanism and cost-effective fermentation strategies.
  europepmc 2026 置信度 0.80
• The role of protein Ser/Thr/Tyr kinases in bacteriophage infection.
  europepmc 2026 置信度 0.80
• Rapid Access to Photoswitchable RNA Binders: Fluorination Enhances Protein Rescue by Exon Inclusion.
  europepmc 2026 置信度 0.80
• Harnessing <i>Cannabis sativa</i> as a dual-use platform for biohydrogen production and pharmaceutical synthesis: a hypothesis and theory.
  europepmc 2026 置信度 0.80
• Engineering Rapamycin-Induced Dimerization for Control of Gene Expression in Plants.
  europepmc 2026 置信度 0.80
• zERExtractor: An Automated Platform for Enzyme-Catalyzed Reaction Data Extraction from Scientific Literature.
  europepmc 2026 置信度 0.80
• Direct Genome Transfer from <i>Acholeplasma laidlawii</i> to Yeast.
  europepmc 2026 置信度 0.80
• Molecular glues and PROTACs: Unlocking targeted protein degradation in plant biology.
  europepmc 2026 置信度 0.80
• Virtual cell: Current perspectives and future prospects.
  Virtual cell is an emerging technology that integrates multiple disciplines, including biology, computer science, and artificial intelligence, to simulate cellular structures and functions. Compared with traditional methods, virtual cell technology offers a mo…
  europepmc 2026 置信度 0.80
• Proteomic landscape of pan-tissue neuroendocrine carcinomas defines subtype-specific functional architectures, biomarkers and therapeutic targets.
  europepmc 2026 置信度 0.80
• Bioluminescent sentinel plants enable autonomous diagnostics of viral infections.
  europepmc 2026 置信度 0.80
• Africa's emerging role in precision oncology: translational insights from the harnessing functional genomics in cancer research conference, Windhoek, 23-26 September 2025.
  Africa is entering a new era of cancer research, driven by renewed commitments to genomic innovation, data equity, and strengthened cancer registry systems. The "Harnessing Functional Genomics in Cancer Research: Opportunities for Diagnosis and Treatment" conf…
  pubmed Rix CL, Buberwa EB, Amofa J, Maurihungirire U 等 2026 置信度 0.82
• Nanofiber-Supported Decellularized Matrix Membrane Creates a Biomimetic Biochemical and Biophysical Niche for Intestinal Organoid Epithelium.
  europepmc 2026 置信度 0.80
• CRISPR/Cas9 Recombineering with Bacteriophage Recombinases Enables Efficient and Scarless Genome Editing in <i>Cupriavidus necator</i> H16.
  europepmc 2026 置信度 0.80
• Effectiveness of mosquito repellents for human: A systematic review of human-based studies.
  Mosquito repellents are personal protection tools against mosquito-borne diseases, but their effectiveness varies across active ingredients, formulations, and mosquito species. This systematic review followed PRISMA 2020 guidance to summarize human studies pub…
  pubmed Faridah L, Nurhakim RA, Astuti RRUNW, Melanie 等 2026 置信度 0.82
• Microbial Systems Enhancing CAR-Based Therapies: A Synthetic Biology Paradigm for Next-Generation Cancer Immunotherapy.
  europepmc 2025 置信度 0.80
• Correction: Chemoautotrophic Thermodesulfobacteriota as a key genomic potential group in the hypoxic diazotrophic community of the Changjiang (Yangtze River) estuary.
  europepmc 2025 置信度 0.80
• Therapeutic Exosomes: From Molecular Biology to Clinical Translation.
  Exosomes, extracellular vesicles of 30-150 nm generated via fusion of multivesicular bodies with the plasma membrane, have evolved from poorly characterized cellular byproducts into a promising platform for translational medicine. Their intrinsic biological pr…
  pubmed Shkurnikov M, Tonevitsky A 2026 置信度 0.82
• Oral live microbial therapeutics: A synthetic biology roadmap toward durable oral microbiome-based therapies.
  europepmc 2026 置信度 0.80
• Corrigendum to 'Insight into the effect and mechanisms of ginsenosides and perilla seed extracts on hepatocellular bioactivities: Hypolipidemic, hypoglycemic, and antioxidant properties' [Fitoterapia 187 (2025) 106932].
  europepmc 2026 置信度 0.80
• Let There be Light! Light as an Engine and Regulator in Synthetic Cells.
  europepmc 2026 置信度 0.80
• Immobilization of Trametes versicolor Laccase Enzyme to Cu-silica Aerogel and its Decolorization of Synthetic Dyes.
  europepmc 2026 置信度 0.80
• Colossal Disinformation
  europepmc 2026 置信度 0.80
• Clarifying the scope and capabilities of ROTS in differential expression analysis.
  europepmc 2026 置信度 0.80
• Palladium-Catalyzed Stereoselective C-2 Arylation of 2,3-Pseudoglycals Using Aryl Diazonium Salts at Room Temperature.
  europepmc 2026 置信度 0.80
• Correction: Solar-powered bioelectrochemical system for efficient cadmium remediation and recovery of reusable solids.
  europepmc 2026 置信度 0.80
• A Global Oceanic Dataset of Dissolved Organophosphate Esters.
  europepmc 2026 置信度 0.80
• [Progress in engineering design and application of electrogenetic systems].
  europepmc 2025 置信度 0.80
• Low-burden and precursor-free cell-cell communication in mammalian cells enabled by denovo design of super-sensitive intercellular signals.
  europepmc 2025 置信度 0.80
• From capability uplift to capability governance: an AI-biosecurity stack.
  europepmc 2026 置信度 0.80
• Efficacy of synthetic and biological DMARDs: a systematic literature review informing the 2025 update of the EULAR recommendations for the management of rheumatoid arthritis.
  europepmc 2026 置信度 0.80
• A turn-on fluorescent nucleoside enabling sequence-insensitive DNA labeling.
  europepmc 2026 置信度 0.80
• Safety of synthetic and biological DMARDs: a systematic literature review informing the 2025 update of the EULAR recommendations for the management of rheumatoid arthritis.
  europepmc 2026 置信度 0.80
• One-Pot Tandem Construction of Isoindolinone Derivatives under Visible-Light Photoredox Catalysis.
  europepmc 2026 置信度 0.80
• Tomato Leaf Color Diversity as a Functional Trait: Molecular Mechanisms, Physiological Significance, and Environmental Responses.
  europepmc 2026 置信度 0.80
• [Biomanufacturing driven by engineered organisms (2026)].
  europepmc 2026 置信度 0.80
• Seasonal Influence on the Bioactive Profile of Essential Oil from Azorean <i>Cryptomeria japonica</i> Foliage: In Vitro and In Silico Studies.
  europepmc 2026 置信度 0.80
• Modulation of Clostridioides difficile virulence by metabolites derived from probiotic consortia and genetically edited strains.
  europepmc 2026 置信度 0.80
• Displacement-Optimized Tanglegrams for Trees and Networks.
  europepmc 2026 置信度 0.80
• Discovery of Non-Carboxylic Steroidal FXR Agonist as a Promising Preclinical Candidate for Metabolic Dysfunction-Associated Steatohepatitis.
  europepmc 2026 置信度 0.80
• Correction: Synthetic method of analogues for emerging infectious disease forecasting.
  europepmc 2025 置信度 0.80
• Nonlinear response relations and fluctuation-response inequalities for nonequilibrium stochastic systems.
  europepmc 2026 置信度 0.80
• RNAi in Insect Physiology: Unlocking Mechanisms and Pioneering Sustainable Pest Control.
  europepmc 2026 置信度 0.80
• Introducing the 2026 Early Career Board of <i>ACS Medicinal Chemistry Letters</i>.
  europepmc 2026 置信度 0.80
• [Recent advances in the application of synthetic biotechnology in production of 5-aminolevulinic acid].
  europepmc 2025 置信度 0.80
• [Microfluidics-driven synthetic biology and biomanufacturing: research progress in methods and applications and future perspectives].
  europepmc 2025 置信度 0.80
• Patchoulol: Bioactive Properties, Synthase Catalytic Mechanisms, and Biosynthetic Progress ── a Review.
  europepmc 2025 置信度 0.80
• MED1-driven ecDNA super-enhancers in cancer.
  europepmc 2025 置信度 0.80
• Genetic encoding of multiple distinct noncanonical amino acids.
  europepmc 2026 置信度 0.80
• Novel Sulfonate Derivatives Functionalized with Triazole-Hydrazone Moieties: Synthesis, Characterization, DFT, Targeting Brain Tumors via DNA Damage, Cytotoxicity, Migration Suppression, Antimicrobial Activity, and In Silico Study.
  europepmc 2026 置信度 0.80
• Artificial Intelligence and Protein Design: A retrospective study on 20-year emerging trends and core research areas from bibliometric perspectives.
  europepmc 2026 置信度 0.80
• A 2025 meeting report from the Venice lagoon: International graduate program <i>RNAmed - Future Leaders in RNA-based Medicine</i> meets on San Servolo.
  europepmc 2026 置信度 0.80
• Edible and Medicinal Mushrooms as Sources of Bioactive Molecules in Pregnancy: Potential Impact on Preeclampsia and Gestational Diabetes Outcomes.
  europepmc 2026 置信度 0.80
• Be Future Ready: Artificial Intelligence & Synthetic Biology
  crossref 2025-12-14T14:55:19Z 置信度 0.70
• Synthetic Cytosolic Splicing Enables Programmable mRNA-Encoded Receptors
  Abstract A typical cell therapy product comprises engineered cells that detect disease-related molecular cues in their surrounding or on a surface of a target cell, and activate a response that alleviates disease symptoms or eradicates diseased cells. mRNA as …
  crossref Matteo Lampis, Yaakov Benenson 2025-04-28T03:00:16Z 置信度 0.70
• Issue Publication Information
  crossref 2025-08-15T07:12:14Z 置信度 0.70