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• Issue Editorial Masthead
  crossref 2025-08-15T07:12:14Z 置信度 0.70
• Reflections on Synthetic Biology in the Manufacturing of Chemicals and Fuels
  crossref Xiujuan Qian, Jie Zhou, Weiliang Dong, Min Jiang 2025-09-01T07:53:01Z 置信度 0.70
• Synthetic Biology As a Postmodern Technology of Care
  Abstract In recent years, synthetic biology emerged as a potentially ground-breaking biotechnology, promising breakthroughs in healthcare, biodiversity conservation and bioremediation. Combining various technoscientific methods, synthetic biology consists in t…
  crossref Daniele Fulvi 2025-07-30T07:11:10Z 置信度 0.70
• Generative design of synthetic gene circuits for functional and evolutionary properties
  1 Abstracts In the past decades, a wide suite of design tools for biological systems have been developed, but using these to create biotechnologies that achieve reliable and predictable behaviour remains challenging. Modelling approaches have enabled researche…
  crossref Olivia Gallup, Harrison Steel 2025-09-28T03:30:13Z 置信度 0.70
• ATP-Powered Signaling between Synthetic and Living Cells
  Abstract ATP is the energy currency of life and overabundant in the tumor microenvironment, where it has been suggested as a target for cancer therapy. We introduce ATP-dissipative delivery of DNA signals from synthetic cells to living cells by exploiting an A…
  crossref Soumya Sethi, Charu Sharma, Andreas Walther 2025-08-14T00:15:29Z 置信度 0.70
• Error Correction Techniques in Synthetic Oligonucleotides and Synthetic DNA
  The review describes methods for correcting errors in synthetic oligonucleotides and genetic constructs derived from them. Methods for isolating oligonucleotides with perfect structure from oligonucleotide pools are discussed. Methods for correcting errors in …
  crossref A. N. Sinyakov 2025-11-12T14:54:28Z 置信度 0.70
• Appendices
  crossref 2025-02-13T02:48:16Z 置信度 0.70
• Introduction
  crossref 2025-02-13T02:48:16Z 置信度 0.70
• Protocols
  crossref 2025-02-13T02:48:16Z 置信度 0.70
• Lipid flip flop regulates the shape of growing and dividing synthetic cells
  Cells grow their boundaries by incorporating newly synthesized lipids into their membranes as well as through fusion of intracellular vesicles. As these processes yield trans-bilayer imbalances in lipid numbers, cells must actively flip lipid molecules across …
  crossref Rafael B. Lira, Cees Dekker 2025-04-25T00:00:15Z 置信度 0.70
• FRONT MATTER
  crossref 2025-02-13T02:48:16Z 置信度 0.70
• Advanced Methods
  crossref 2025-02-13T02:48:16Z 置信度 0.70
• Design of Parameter Intervals to Meet Steady-State Specifications in Biomolecular Circuits using Interval Analysis
  It is often desired, in the analysis or the design of biomolecular circuits, to search for parameters that satisfy certain specifications, such as on the number of the steady states or on their magnitudes. These problems are challenging because of the presence…
  preprints 2024 置信度 0.74
• AistSeq: An In-House Tn5-Based Plasmid Sequencing Platform Using A Compact Benchtop Sequencer
  preprints 2024 置信度 0.74
• OneSC: A computational platform for recapitulating cell state transitions
  preprints 2024 置信度 0.74
• Control of Prion Uptake by Bone Morphogenetic Protein Signaling
  preprints 2025 置信度 0.74
• A Field-Deployable Arsenic Sensor Integrating <i>Bacillus Megaterium</i> with CMOS Technology
  preprints 2024 置信度 0.74
• usiGrabber: Automating the curation of proteomics spectra data at scale, making large datasets ready for use in machine learning systems
  preprints 2026 置信度 0.74
• The environmental stress response controls the biophysical properties of the cytoplasm and is critical for survival in quiescence
  preprints 2025 置信度 0.74
• High-throughput development and characterization of new functional nanobodies for gene regulation and epigenetic control in human cells
  preprints 2024 置信度 0.74
• Creating overlapping genes by alternate-frame insertion
  preprints 2024 置信度 0.74
• Identification of novel broad host-range promoter sequences functional in diverse <i>Pseudomonadota</i> by a promoter-trap approach
  preprints 2024 置信度 0.74
• SpatialPPI 2.0: Enhancing Protein-Protein Interaction Prediction through Inter-Residue Analysis in Graph Attention Networks
  preprints 2024 置信度 0.74
• Machine learning based pan-plant analyses of transposable elements across 352 species illuminates genome evolution
  preprints 2024 置信度 0.74
• FoldMark: Safeguarding Protein Structure Generative Models with Distributional and Evolutionary Watermarking
  preprints 2024 置信度 0.74
• AlloPool: An Adaptive Graph Neural Network for Dynamic Allosteric Network Prediction in Protein Systems
  preprints 2024 置信度 0.74
• PXGS: a Poly-Transgene Expression System based on Mutually Exclusive Splicing of Dscam
  preprints 2024 置信度 0.74
• Designing minimal <i>E. coli</i> genomes using variational autoencoders
  preprints 2024 置信度 0.74
• A digital DNA system reveals the superiority of unidirectional inheritance over ‘Lamarckian’ inheritance
  preprints 2024 置信度 0.74
• BioPathNet: Enhancing Link Prediction in Biomedical Knowledge Graphs through Path Representation Learning
  preprints 2024 置信度 0.74
• Small molecule and cell contact-inducible systems for controlling expression and differentiation in stem cells
  preprints 2024 置信度 0.74
• ROS1 immunohistochemistry as a potential predictive biomarker for ROS1-targeted therapy in breast cancer: impact of antibody clone selection
  preprints 2024 置信度 0.74
• Kinetic logic of uridylation-mediated RNA decay
  preprints 2026 置信度 0.74
• Guidance of cellular nematics into shape-programmable living surfaces
  preprints 2025 置信度 0.74
• Dissecting current rectification through asymmetric nanopores
  preprints 2024 置信度 0.74
• Exchange, promiscuity, and orthogonality in <i>de novo</i> designed coiled-coil peptide assemblies
  preprints 2024 置信度 0.74
• Diversified, miniaturized and ancestral parts for mammalian genome engineering and molecular recording
  preprints 2024 置信度 0.74
• Uncovering the class II-bacteriocin predatiome in salivarius streptococci
  preprints 2024 置信度 0.74
• PreciCE: Precision engineering of cell fates via data-driven multi-gene control of transcriptional networks
  preprints 2024 置信度 0.74
• Optimal transport reveals dynamic gene regulatory networks via gene velocity estimation
  preprints 2024 置信度 0.74
• Synthetic autotrophic yeast enables high itaconic acid production from CO ₂ via integrated pathway and process design
  preprints 2025 置信度 0.74
• Temporal loss of genome-wide and immunogenetic diversity in a near-extinct parrot
  preprints 2024 置信度 0.74
• Sustainable Regeneration of 20 Aminoacyl-tRNA Synthetases in a Reconstituted System Toward Self-Synthesizing Artificial Systems
  preprints 2024 置信度 0.74
• Protein design of two-component tubular assemblies like cytoskeletons
  preprints 2024 置信度 0.74
• A Genetic Toggle Switch in Plants
  preprints 2024 置信度 0.74
• Cross-Species Aging Knowledge Integration into Agentic AI Platform Uncovers Conserved Mechanisms
  Abstract Aging research has been advanced largely through the use of model organisms, where short lifespans and genetic tractability enable the systematic discovery of molecular pathways influencing longevity and age-related decline. However, knowledge about a…
  preprints 2026 置信度 0.74
• Developing global research roadmaps for alternatives to antimicrobials in animal health: a participatory expert-driven approach
  preprints 2026 置信度 0.74
• Design of an intracellular aptamer-based fluorescent biosensor to track burden in E. coli
  preprints 2024 置信度 0.74
• Ultrasensitive Peptide-Based Electrochemical Biosensor for Universal Diagnostic of Dengue
  preprints 2024 置信度 0.74
• Classifier architecture and data preprocessing jointly shape accelerometer-based behavioural inference
  preprints 2026 置信度 0.74
• CAR-NK cells with dual targeting of PD-L1 and MICA/B in human lung cancer H1299 cell tumor model
  preprints 2024 置信度 0.74
• Spatio-temporal regulation of ligand trafficking and TLR9 activation involves PIEZO1 mechanosensing in human plasmacytoid dendritic cells
  preprints 2025 置信度 0.74
• Protein Structuromics Reveals a Loop-Controlled Half-Open Active Pocket Conformation Throughout Fe(II)/α-ketoglutarate-Dependent Dioxygenase Catalytic Cycle.
  europepmc 2026 置信度 0.80
• Closing the implementation gap: a harmonised EU framework for synthetic nucleic acid screening and customer verification.
  Synthetic nucleic acid technologies underpin modern biological research and biomanufacturing. However, their growing accessibility through commercial synthesis services, benchtop devices, and AI-assisted design tools creates significant dual-use biosecurity ri…
  pubmed Peresson S, Stadler P 2026 置信度 0.82
• Rhizobacteria-Mediated Reprogramming of Phytohormone Landscapes for Mitigating Salinity Stress in Plants.
  europepmc 2026 置信度 0.80
• Author Correction: EXCRETE workflow enables deep proteomics of the microbial extracellular environment.
  europepmc 2026 置信度 0.80
• Editorial: Insights in biosafety and biosecurity 2024/2025: novel developments, current challenges, and future perspectives.
  europepmc 2026 置信度 0.80
• Bacteriophage therapy against multidrug resistant bacterial infections demonstrates clinical advances and engineering innovations between 2020-2026.
  The global crisis of antimicrobial resistance has reached critical levels, with multi-drug resistant (MDR) bacterial pathogens threatening to render conventional antibiotics ineffective. This mini review synthesizes recent evidence from 2020 to 2026 on bacteri…
  pubmed Alzahrani AJ 2026 置信度 0.82
• In vitro enzyme-mediated conversion of methane and methanol toward value-added chemicals.
  europepmc 2026 置信度 0.80
• Advancing the frontier of plant-based therapeutics: critical innovations in molecular farming and bioprocess Integration.
  europepmc 2026 置信度 0.80
• Unveiling the mechanistic principles and engineered exploitation of bacteria and derivatives in precision drug delivery.
  europepmc 2026 置信度 0.80
• A dual self-regulatory platform for programmable biosynthesis of L-lysine-derived alkaloids.
  europepmc 2026 置信度 0.80
• Tunable Transcription-Level CRISPR Interference in &lt;i&gt;Vibrio natriegens&lt;/i&gt; Using Engineered Single Guide RNAs.
  europepmc 2026 置信度 0.80
• Microbial and Enzymatic Degradation of Nylon: Mechanisms, Diversity, and Biotechnological Application.
  europepmc 2026 置信度 0.80
• Bibliometric analysis of genetically engineered bacteria in tumor therapy.
  europepmc 2026 置信度 0.80
• Securing the U.S. nucleic acid synthesis industry: a case for safe-harbor information sharing.
  europepmc 2026 置信度 0.80
• Beyond Simple Mimicry: Next-Generation Geometric Architectures and Future Paradigms in Small-Molecule and Macrocyclic Peptidomimetics.
  Peptidomimetics have matured from motif&#x2011;based inhibitors into a structural engineering discipline that systematically translates peptide recognition surfaces into drug&#x2011;like scaffolds. Driven by the urgent clinical demand to overcome the inherent …
  pubmed Lee J, Son S, Yoo JY, Lee JH 等 2026 置信度 0.82
• Receptor-Guided AAV Tropism Engineering via MATCH.
  europepmc 2026 置信度 0.80
• Dynamic Exchange Assembly of Enzymes with Single-Crystal Covalent Organic Frameworks.
  europepmc 2026 置信度 0.80
• Global research trends and hotspots of plant physiologically active substances: quantitative visualization analysis based on CiteSpace.
  europepmc 2026 置信度 0.80
• A Validated LC-MS/MS Method for Simultaneous Determination of Cortisol and Cortisone in Grey Wolf Hair for Application in Ecological Studies.
  europepmc 2026 置信度 0.80
• Evaluating synthetic substitutes to reduce illegal harvesting and support species recovery.
  europepmc 2026 置信度 0.80
• Polymeric Biomaterials for the Delivery of Stem Cell-Derived Exosomes in Inflammatory Skin Diseases: Engineering Strategies and Synergistic Effects.
  Skin tissue engineering has emerged as a promising therapeutic strategy for severe wounds and inflammatory skin diseases. Stem cell-derived exosomes (SC-Exos) have recently gained increasing attention as cell-free therapeutic agents with regenerative and immun…
  pubmed Noh M, Heo TH, Kang MK, Jeong GJ 2026 置信度 0.82
• Synthetic microbiomes in bioengineered rhizospheres: new frontiers for climate-resilient agriculture.
  Climate change poses significant threats to global agricultural productivity, necessitating innovative strategies to ensure food security and ecological sustainability. One promising avenue lies in the deliberate design and deployment of synthetic microbiomes …
  europepmc 2026 置信度 0.80
• A Scalable COF-Based Sequestrant for Synergistic Bile Acid Modulation in Fatty Liver Disease.
  europepmc 2026 置信度 0.80
• Modular pathway engineering for enhancing terpenoid production in plants.
  europepmc Yeo Jin Lee, Sun-Hwa Ha 2026 置信度 0.80
• Synergistic interaction between the macrophage polarizing signals IL-4 and IFNγ is controlled by the STAT6/STAT1/IRF1 axis.
  europepmc 2026 置信度 0.80
• KIF7 promotes the proliferation of clear cell renal cell carcinoma by activating the WNT/β-catenin signaling pathway.
  europepmc 2026 置信度 0.80
• Growth-coupled evolution accelerates efficient biosynthesis of natural products.
  europepmc 2026 置信度 0.80
• EVennCorona: Annotating Protein Corona of Extracellular Vesicles by Venn Diagram.
  europepmc 2026 置信度 0.80
• Engineering the bacterial cellulose-forming surface as a programmable protein recruitment interface
  europepmc 2026 置信度 0.80
• Engineering glowing plants: recent progress and future directions for application-oriented design.
  europepmc 2026 置信度 0.80
• A CURE for synthetic regulation of gene expression: rapid screening of guide RNA efficacy as a framework for enabling undergraduate research in plant synthetic biology.
  europepmc 2026 置信度 0.80
• Dynamic Interaction: Synthetic Biology and Cell-Free Biosensors Drive Each Other Forward.
  europepmc 2026 置信度 0.80
• Characterization and Immobilization of a High Activity Lysine Decarboxylase from Serratia Proteamaculans NJ303 for Cadaverine Production.
  Cadaverine, an essential precursor for bio-based nylon PA5X production, has emerged as a highly valuable compound in the engineered plastics and synthetic fibers industry. Current industrial biomanufacturing of cadaverine depends critically on the enzymatic ac…
  pubmed Wei G, Zhou N, Wei J, Zhang A 等 2026 置信度 0.82
• Improvements in chemical reaction pathway exploration algorithms and dataset generation.
  europepmc 2026 置信度 0.80
• Microbial-driven nature-based solutions for environmental antimicrobial resistance and emerging contaminants: mechanisms, platform trade-offs, and decision framework.
  europepmc 2026 置信度 0.80
• Synthetic nucleic acids in a post-agent biosecurity Era.
  europepmc 2026 置信度 0.80
• Multilayer regulation of CRISPR systems: integrating anti-CRISPR proteins, CRISPRi/a, and quorum sensing networks.
  The CRISPR-Cas system has evolved into a highly efficient platform for genome editing and programmable gene regulation, demonstrating broad application potential in microbiology, biotechnology, and medicine. However, traditional CRISPR tools typically rely on …
  europepmc 2026 置信度 0.80
• Correction for Ipoutcha et al., "A synthetic biology approach to assemble and reboot clinically relevant &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; tailed phages".
  europepmc 2026 置信度 0.80
• Beyond pesticides: next-generation genetic biocontrol technologies for sustainable population suppression of agricultural insect pests.
  Chemical insecticides have long been used to control agricultural pests, but their widespread application has driven resistance and caused significant ecological and health impacts. CRISPR/Cas9-based genetic biocontrol technologies, including the precision-gui…
  pubmed Hill E, Raban R, Akbari OS 2026 置信度 0.82
• &lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt; PPE2 protein-derived peptide ameliorates DSS-induced colitis by depleting mast cells.
  europepmc 2026 置信度 0.80
• Microscopic Fungi as Sources of Natural UV-Protective Compounds.
  The search for sustainable and biocompatible alternatives to synthetic sunscreens has intensified due to concerns about the safety and environmental persistence of conventional UV filters. Although algae and bacteria have been extensively explored as sources o…
  pubmed Urrea-Victoria V, Aránzazu Suarez V, Castellanos Hernández L, Aragón Novoa DM 2026 置信度 0.82
• Zhongchi Liu.
  europepmc 2026 置信度 0.80
• Emergence of a novel GII.17 variant is associated with immune evasion rather than an altered HBGA-binding profile.
  The epidemiology of noroviruses, a major cause of gastroenteritis in humans, is shaped by their continuous evolution. Novel genotypes and variants periodically emerge, replacing previously dominant strains. In 2024, a novel GII.17 variant led to an increased n…
  pubmed van der Krieken ST, Morais Esteves F, Villabruna N, Schapendonk CME 等 2026 置信度 0.82
• Valorization of Ficus carica Pruning Residues as Selective Botanical Insecticides: Optimized Furanocoumarin Extraction, Efficacy Against Neotropical Stink Bugs, and Mechanistic Insights via Molecular Docking.
  europepmc 2026 置信度 0.80
• De Novo Biosynthesis of Valinomycin From Glucose Using In Vitro Reconstituted Hybrid Pathways.
  In vitro biotransformation mediated by cell-free biosynthetic systems provides a flexible biomanufacturing platform that enables the reconstitution of hybrid metabolic pathways for complex natural product biosynthesis from simple substrates. Here, we report th…
  pubmed Huang S, Liu WQ, Li J 2026 置信度 0.82
• Optimization of Deep Eutectic Solvent Extraction Process and Study on the Anti-Alcoholic Fatty Liver Disease Activity and Mechanism of Flavonoids From Lophatherum gracile Brongn.
  europepmc 2026 置信度 0.80
• Botanical defence: medicinal plants as botanical insecticides against &lt;i&gt;Locustana pardalina&lt;/i&gt; Walker (Orthoptera: Acrididae).
  Food crop infestations caused by the insect pest Locustana pardalina threaten global food security, particularly in developing regions. This pest can devastate entire crops, exacerbating malnutrition and economic instability. Traditionally, L. pardalina outbre…
  pubmed Mbuyiswa AN, Gwanya HY, Phokwe OJ, Gxaba N 等 2026 置信度 0.82
• Development of an HSV-1 F strain BAC system using the synthetic platform.
  europepmc 2026 置信度 0.80