合成生物与生物制造 · 全部实体（第 66 / 100 页）

本页收录第 6501–6600 条，共 10000 条 · 返回 合成生物与生物制造 首页

• Bacterial mRNA Vaccines: Programming Immunity Against Antimicrobial Resistance.
  The relentless rise of antimicrobial resistance poses a critical threat to global health, urgently demanding the development of antibacterial vaccines. Messenger RNA (mRNA) technology, validated during the COVID-19 pandemic, offers a powerful platform of fast …
  pubmed Liao R, Luo M, Yang F, Xu L 等 2026 置信度 0.82
• Systems biology in the era of AI: "winter" or "evolution"?
  europepmc 2026 置信度 0.80
• Mechanistic Insights into Amide Hydrogenation via Ru-PNNH Metal-Ligand Cooperation: A DFT Study.
  europepmc 2026 置信度 0.80
• Fecal filtrate transplantation as salvage therapy for fulminant <i>Clostridioides difficile</i> infection in adult hematological patients during chemotherapy-induced aplasia: a pilot experience.
  europepmc 2026 置信度 0.80
• Antimicrobial peptides: emerging next-generation strategy for sustainable plant disease management.
  europepmc 2026 置信度 0.80
• Cross-plane shear wave elastography for viscoelasticity imaging.
  europepmc 2026 置信度 0.80
• An extracellular, optogenetic antibody platform for stimulus-gated antigen recognition and modulation of cell behavior.
  europepmc 2026 置信度 0.80
• Integrating AI in seed science: Toward an intelligent design paradigm.
  Global agricultural systems face mounting threats to food security from climate change, population growth, and land degradation, with current productivity gains insufficient to meet the demands of a projected global population of 9.7 billion by 2050. Seeds, as…
  europepmc 2026 置信度 0.80
• Toward molecular classification architectures for cell-free diagnostics.
  europepmc 2026 置信度 0.80
• RPI-PLMGNN: Enhancing RNA-Protein Interaction Prediction with the Pretrained Large Language Models and Graph Neural Networks.
  europepmc 2026 置信度 0.80
• Achieving bottom-up ethical, legal, and societal implications and responsible research and innovation in the synthetic biology research community from the Japanese context.
  Biomanufacturing and synthetic biology are increasingly seen as essential to realizing a global bioeconomy. Within the broader trends in science and technology policy, the emphasis on foresight and addressing societal challenges has been growing. Addressing et…
  europepmc 2026 置信度 0.80
• TargetGAN: A generative AI framework for the design of plant core promoters with targeted activity.
  europepmc 2026 置信度 0.80
• ADAPT: a programme for the advanced detection of AI-enabled pathogenic threats.
  Advances in AI are expanding both the ceiling and the accessibility of biological engineering, creating threats that existing synthetic nucleic acid screening is not equipped to detect. The IARPA-funded Functional Genomic and Computational Assessment of Threat…
  europepmc 2026 置信度 0.80
• Immunochemical and Conformational Properties of Structurally Defined Homo-oligo-β-d-glucosides: Examples of Gradual and Extremal Length Dependences.
  europepmc 2026 置信度 0.80
• Correction: Barszczewska-Pietraszek et al. Polθ Inhibitor (ART558) Demonstrates a Synthetic Lethal Effect with PARP and RAD52 Inhibitors in Glioblastoma Cells. <i>Int. J. Mol. Sci.</i> 2024, <i>25</i>, 9134.
  europepmc 2026 置信度 0.80
• Product-Responsive Regulation of NADPH and Malonyl-CoA Allocation Enhances 3-Hydroxypropionic Acid Production in <i>Escherichia coli</i>.
  europepmc 2026 置信度 0.80
• Machine Learning in Microbiome Research and Engineering.
  europepmc 2026 置信度 0.80
• Editing and synthetic engineering of chloroplast genomes.
  europepmc 2026 置信度 0.80
• A systems-level atlas of carbon-response transcriptional states in <i>Escherichia coli</i>.
  europepmc 2026 置信度 0.80
• Biosecurity in the age of synthetic nucleic acids: modernizing the law to manage emerging threats.
  europepmc 2026 置信度 0.80
• Gene loss and compensatory evolution as a source of metabolic preadaptations.
  europepmc 2026 置信度 0.80
• Tumour-Derived Extracellular Vesicles Containing dsRNA Induce Degradation of Ribosomal Protein mRNA in Platelets.
  Extracellular vesicles (EVs) mediate intercellular communication within the tumour microenvironment by carrying cargoes from paracrine parent cells. EVs have attracted great research interest for their ability to carry nucleic acids into recipient cells and mo…
  pubmed Sun G, Tao Y, Liu Z, Zhang K 等 2026 置信度 0.82
• Multilevel Regulation in RNA-Protein Hybrid Incoherent Feed-Forward Loop Circuits for Tunable Pulse Dynamics in <i>Escherichia coli</i>.
  Regulating gene expression with precision is essential for cellular engineering and biosensing applications, where rapid, programmable, and sensitive control is desired. Current approaches to regulatory circuit design often rely on control at a single regulato…
  europepmc 2026 置信度 0.80
• Microbial spies and bloggers: programming cells to convert environmental information into discernible signals.
  europepmc 2026 置信度 0.80
• Programmable saponin biosynthesis from gene networks to predictive biomanufacturing.
  Saponins are a structurally diverse plant glycosides with important ecological functions and broad pharmaceutical and industrial value. Recent advances have shifted saponin research from descriptive pathway elucidation toward predictive and programmable bioman…
  europepmc Yuan Wang, Jiahong Chen, Zhonghong Liao, Li Yin 等 2026 置信度 0.80
• Sustainable bioenergy manufacturing in plants.
  europepmc 2026 置信度 0.80
• Complete Utilization of Poly(butylene Adipate-co-terephthalate) Monomers and Production of Polyhydroxybutyrate by a Levulinic Acid-Mediated Microbial Consortium of Pseudomonas putida and Cupriavidus necator.
  europepmc 2026 置信度 0.80
• Engineered Bacteria as Living Materials for Oral Delivery of Peptide Drugs.
  europepmc 2026 置信度 0.80
• Microfluidic Chip-Based <i>In Vitro</i> Screening System of Synthetic Signal Peptides for Enhanced Monoclonal Antibody Production in Chinese Hamster Ovary Cells.
  europepmc 2025 置信度 0.80
• Targeting phosphofructokinase in cancer: integrating natural products for metabolic reprogramming and therapeutic innovation.
  The metabolism of cancer cells is reprogrammed toward aerobic glycolysis (the Warburg effect), which stimulates tumor growth. Phosphofructokinase (PFK) and its isoforms, PFKP, PFKM, and PFKL, are highly conserved central glycolytic controllers and a potential …
  pubmed Cao C, Lv C, ElFar A 2026 置信度 0.82
• Lung organoids for respiratory diseases: overcoming translational hurdles in drug discovery and safety assessment.
  europepmc 2026 置信度 0.80
• Challenges in melanoma research and increased melanoma risk call for novel methodological and therapeutic/protective strategies: the case of procyanidin C1 targeting redox metabolism.
  europepmc 2026 置信度 0.80
• Strategies for the Selection and Application of Biological Scaffolds in Organ-on-a-Chip Systems.
  europepmc 2026 置信度 0.80
• Generative artificial intelligence in animal genomics for smart agriculture: Applications, challenges, and future prospects.
  Generative artificial intelligence (AI) is becoming a groundbreaking paradigm in the field of animal genomics and is providing the possibility to take a step towards intelligent agriculture, with better data integration, predictive modeling, and biological des…
  europepmc 2026 置信度 0.80
• Emerging Applications of CAR-T Cell Therapy in Overcoming Resistance and Expanding Targets in Hematologic Malignancies: Insights from Recent Research.
  europepmc 2026 置信度 0.80
• EGGS: Empirical Genotype Generalizer for Samples.
  europepmc 2026 置信度 0.80
• Double-CRISPR Knockout Simulation (DKOsim): A Monte-Carlo randomization system to model cell growth behavior and infer the optimal library design for growth-based double knockout screens.
  europepmc 2026 置信度 0.80
• Engineering next-generation crops through CRISPR-mediated horizontal gene transfer.
  europepmc 2026 置信度 0.80
• AI-driven discovery in protein science for immunology and infectious disease research.
  europepmc 2026 置信度 0.80
• Decoding plant physiology through systems biology: Integrative multi-omics and computational perspectives for next-generation crop design.
  europepmc 2026 置信度 0.80
• Engineered bacteria as living therapeutics: Next-generation precision tools for health, industry, environment, and agriculture.
  europepmc 2025 置信度 0.80
• Advanced applications of synthetic biology technology in biosynthesis of bioactive compounds from medicinal plants.
  europepmc 2026 置信度 0.80
• A Nonparametric Approach to Practical Identifiability of Nonlinear Mixed Effects Models.
  europepmc 2026 置信度 0.80
• Brave new RNA world(s): from prebiotic chemistry to gene regulation and RNA technology.
  europepmc 2026 置信度 0.80
• The plastisphere: not a unique biofilm but a unifying concept for the interdisciplinary plastic biofilm research community.
  europepmc 2026 置信度 0.80
• Simulating targeted vaccination strategies with network-based and agent-based models: A scoping review.
  europepmc 2026 置信度 0.80
• The alarming rate of carbapenem-resistant Klebsiella pneumoniae in Serbia: A deep dive into genomic diversity, resistome, hypervirulence, and expansion of high-risk clone ST147/bla<sub>NDM-1</sub>.
  europepmc 2026 置信度 0.80
• Digital twins for plant-microbe interactions: Gap finding and filling.
  europepmc 2026 置信度 0.80
• KELPE: knock-in exchangeable dual landing pad embryonic stem cells enable efficient screening of synthetic gene circuits
  The establishment of genetic circuits in pluripotent stem cells (PSCs) allows to model and manipulate developmental events. However, prototyping complex circuitry remains challenging, due to limitations in screening circuit components and transgene silencing. …
  europepmc 2026 置信度 0.80
• RATEX: A Scalable RNA-Based Platform for Logical and Multi-Layered Cellular Programming.
  Scalable genetic circuits are essential for implementing complex functions in living cells. Toward this goal, RNA regulators can provide a much-needed parts library with added benefits of low metabolic load, design flexibility, and logic capacity. However, des…
  europepmc 2026 置信度 0.80
• <i>Streptomyces</i> as a versatile host platform for heterologous production of microbial natural products.
  europepmc 2026 置信度 0.80
• Approaches for accelerating microbial gene function discovery using artificial intelligence.
  europepmc 2026 置信度 0.80
• Chemical Annotation and Biological Evaluation of Prenylated Benzophenone-Rich Fractions from <i>Clusia grandiflora</i> Fruits: Integrated In Vitro and In Silico Analyses of Antileishmanial Activity, Nitric Oxide Modulation, and Stage-Dependent Cell Death Phenotypes.
  europepmc 2026 置信度 0.80
• Discovery, characterization, and application of chromosomal integration sites in the hyperthermophilic archaeon Sulfolobus islandicus.
  europepmc 2026 置信度 0.80
• Fungal Biotechnology and Application 3.0.
  Fungi represent one of the most diverse and functionally versatile groups of organisms on Earth, with profound impacts on human health, food security, industrial manufacturing, environmental remediation, and ecological sustainability [...].
  europepmc 2026 置信度 0.80
• Stochastic intracellular calcium dynamics show preserved structures identified by deep learning classification.
  europepmc 2026 置信度 0.80
• Integration of Biopesticides into Apple Scab Management Programs Using Disease Forecasting and Modern Planting Systems.
  europepmc 2026 置信度 0.80
• The human microbiome as a source of novel bioactive natural products: structures, bioactivities, and biosynthetic insights.
  europepmc 2026 置信度 0.80
• Viral vectors for antimicrobial peptide expression: a new path for crop protection.
  Antimicrobial peptides (AMPs) are key components of plant innate immunity, offering broad spectrum protection against pathogens and represent promising alternatives to chemical pesticides for sustainable crop protection. Despite their broad range antimicrobial…
  europepmc 2026 置信度 0.80
• Integrated physiological, hormonal, and transcriptomic analyses reveal pistil responses to pollen sources of varying compatibility in 'Fengtang' plum (Prunus salicina).
  europepmc 2026 置信度 0.80
• A modular single- and dual-gene expression toolkit for Kluyveromyces marxianus.
  europepmc 2026 置信度 0.80
• Rewiring gene circuits to dissect oscillatory signaling dynamics.
  Precise intercellular communication is critical for cellular decision-making. The segmentation clock is an oscillatory gene network regulating periodic segmentation of the presomitic mesoderm (PSM) in vertebrate embryos. Oscillations between neighboring cells …
  europepmc 2026 置信度 0.80
• Synthetic promoter design in plants: integration of computational and experimental approaches.
  Understanding how to engineer transcriptional regulation in plants is key to advancing both fundamental knowledge and practical applications in plant biology. Native gene promoters, while widely used, are constrained by evolutionary pressures that limit their …
  europepmc Anna E. Yaschenko, Jose Alonso, Anna N. Stepanova 2026 置信度 0.80 PromoterSynthetic biologyComputational biologyBiologyCis-regulatory module
• Recent strategies in synthetic food production for sustainable food security: applications and challenges.
  Due to rapid growth in population, instability in conventional agricultural production, and depletion of natural resources, currently, there is huge pressure to fulfill the demands for nutritious, safe, and cheaper food. Environmental changes have also impacte…
  pubmed Kanaujia PK, Tripathi M, Rai NK, Singh RP 等 2026 置信度 0.82
• Systems-Level Insights Into Microbial Naphthalene Biodegradation: An Integrated In Silico and Omics Perspective.
  europepmc 2026 置信度 0.80
• Biomanufacturing of Natural Bioactive Compounds.
  Natural bioactive compounds (NBC) have been research targets for decades due to their various usages in agriculture, industry, and more importantly, pharmaceuticals [...]
  europepmc Honglei Liu 2026 置信度 0.80
• Alzheimer's disease in the <i>Plasticene</i> era: a clinicopathological update on the dual sequestration of amyloid and tau as hijacked innate immune responses.
  europepmc 2026 置信度 0.80
• Biohacking the human gut microbiome for precision health and therapeutic innovation.
  europepmc 2026 置信度 0.80
• Editorial: Exploring the role of plant phytochemical diversity in biodiversity and beyond.
  europepmc 2026 置信度 0.80
• Beyond sequence similarity: toward function-based screening of nucleic acid synthesis.
  europepmc 2026 置信度 0.80
• Bioengineering hybrid artificial life.
  europepmc 2025 置信度 0.80
• From fermentation to function: a critical review of lactic acid bacteria redesign for functional foods and precision nutrition.
  europepmc 2026 置信度 0.80
• Antibiotic-induced gut microbiome dysbiosis: risks and strategies for mitigation.
  europepmc 2026 置信度 0.80
• Targeting NRF2 addiction in cancer: synthetic lethal strategies beyond direct inhibition.
  europepmc 2026 置信度 0.80
• Compounding asymmetries in nucleic acid synthesis screening: policy pathways for strengthening global biosecurity governance.
  Order screening for synthetic nucleic acids has become a central element of biosecurity policy in several jurisdictions, including the United States, European Union, New Zealand, and United Kingdom. Yet global uptake remains uneven. Many providers, particularl…
  europepmc 2026 置信度 0.80
• Exploring the antihyperglycemic potential of <i>Durio kutejensis</i> (Hassk.) Becc.: <i>in vitro</i>, <i>in vivo</i>, and metabolomic examinations.
  europepmc 2026 置信度 0.80
• Pharmacological evaluation reveals distinct anti-proliferative and migration-associated effects of curcumin analogues B-143 and B-155 in ovarian cancer cells.
  europepmc 2026 置信度 0.80
• Design of synthetic selenopeptides with antioxidant activity for the treatment of XP and non-melanoma skin cancer.
  europepmc 2026 置信度 0.80
• Rule-breaking in chemical synthesis.
  europepmc 2026 置信度 0.80
• Harnessing Immunogenic PANoptosis With Iridium(III) Biradical Photosensitizers for Melanoma Photoimmunotherapy.
  europepmc 2026 置信度 0.80
• Editorial: Probiotics in aquaculture: enhancing health and sustainability.
  Aquaculture has become indispensable to global food and nutritional security (FAO, 2024), but its continued expansion has intensified persistent biological and environmental pressures.Infectious diseases, however, deteriorating water quality, metabolic disorde…
  europepmc 2026 置信度 0.80
• Yeast bioaugmentation fosters medium-chain carboxylates and polyhydroxyalkanoates production from cheese whey.
  europepmc 2026 置信度 0.80
• <i>In vitro</i> assays to monitor membrane fusion.
  europepmc 2026 置信度 0.80
• Degradation pathway of (R)-1,3-butanediol in <i>Pseudomonas putida</i> KT2440 and development of its biosensor.
  europepmc 2026 置信度 0.80
• Advanced Cellulose-Based Materials: From Nanoparticles to Complex Structures and Composites.
  europepmc 2026 置信度 0.80
• Editorial: Advancing plant defense: genome editing, RNAi, and synthetic biology for sustainable pest control.
  europepmc 2026 置信度 0.80
• Fecal microbiota and microbial community transplantation: <b>a</b> review of current research.
  europepmc 2026 置信度 0.80
• Microplastic contamination in remote mountain lakes of the americas: a baseline assessment from Patagonia and Northern California.
  europepmc 2026 置信度 0.80
• Special Issue "Genetic Engineering of Plants for Stress Tolerance".
  europepmc 2025 置信度 0.80
• Next-generation interleukin-enhanced immunotherapies: From molecular engineering to armored T-cell architectures.
  europepmc 2026 置信度 0.80
• PREreview of "Role of staphylococcal EzrA as a molecular organizer of cell division"
  This Zenodo record is a permanently preserved version of a PREreview. You can view the complete PREreview at https://prereview.org/reviews/19937904. The manuscript by Azam et al. examines the role of EzrA as a regulator of cell division. The authors explored t…
  datacite Alizée Malnoë, Tahreem Zaheer, Josy Joseph, Carter Collins 等 2026 置信度 0.66
• PREreview of "Role of staphylococcal EzrA as a molecular organizer of cell division"
  This Zenodo record is a permanently preserved version of a PREreview. You can view the complete PREreview at https://prereview.org/reviews/19937904. The manuscript by Azam et al. examines the role of EzrA as a regulator of cell division. The authors explored t…
  datacite Alizée Malnoë, Tahreem Zaheer, Josy Joseph, Carter Collins 等 2026 置信度 0.66
• The Kayser–Cuny Mathematical Tables in Molecular and Synthetic Biology: A Molecular Information Framework
  The Kayser-Cuny Mathematical Tables present a numerical framework that reveals hidden patterns and invariant relationships within the genetic code through the lens of atomic composition, combinatorics and mathematical logic. By assigning logical values to each…
  datacite Kayser-Cuny, Victoria 2026 置信度 0.66
• The Kayser–Cuny Mathematical Tables in Molecular and Synthetic Biology: A Molecular Information Framework
  The Kayser-Cuny Mathematical Tables present a numerical framework that reveals hidden patterns and invariant relationships within the genetic code through the lens of atomic composition, combinatorics and mathematical logic. By assigning logical values to each…
  datacite Kayser-Cuny, Victoria 2026 置信度 0.66
• Topological Mapping of Whole-Cell Proteomic Networks via Semantic Pixel Chromatic Compression and Quantum Image Processing
  1. ENGLISH VERSION Title: Topological Mapping of Whole-Cell Proteomic Networks via Semantic Pixel Chromatic Compression and Quantum Image Processing: Theoretical Framework Description: This repository contains the formal, peer-review-ready mathematical and alg…
  datacite Usai, Luigi 2026 置信度 0.66
• Topological Mapping of Whole-Cell Proteomic Networks via Semantic Pixel Chromatic Compression and Quantum Image Processing
  1. ENGLISH VERSION Title: Topological Mapping of Whole-Cell Proteomic Networks via Semantic Pixel Chromatic Compression and Quantum Image Processing: Theoretical Framework Description: This repository contains the formal, peer-review-ready mathematical and alg…
  datacite Usai, Luigi 2026 置信度 0.66
• HyperPSCA: A Unified Autopoietic Hypergraph Engine for Cross-Domain Scientific Discovery, Patent Screening, and Material/Biomedical Co-Evolution
  🇬🇧 English Version Title HyperPSCA: A Unified Autopoietic Hypergraph Engine for Cross-Domain Scientific Discovery, Patent Screening, and Material/Biomedical Co-Evolution Description/Abstract This repository introduces the computational infrastructure of Hype…
  datacite Usai, Luigi 2026 置信度 0.66 pscaparadigma sardo corsoparadigma sardo corso atlantideoLuigi UsaiUsai Luigi
• Six-fold Integrated Criteria for Non-equilibrium Living Manifolds
  Abstract The essential demarcation between living and non-living systems remains one of the central challenges in natural science. Traditional definitions rely on isolated lists of features such as metabolism, reproduction, and responsiveness, which fail to co…
  datacite Zhang, Xuchao 2026 置信度 0.66 definition of life; integrated information; edge of chaos; non-equilibrium thermodynamics; constraint satisfaction; synthetic biology
• Six-fold Integrated Criteria for Non-equilibrium Living Manifolds
  Abstract The essential demarcation between living and non-living systems remains one of the central challenges in natural science. Traditional definitions rely on isolated lists of features such as metabolism, reproduction, and responsiveness, which fail to co…
  datacite Zhang, Xuchao 2026 置信度 0.66 definition of life; integrated information; edge of chaos; non-equilibrium thermodynamics; constraint satisfaction; synthetic biology
• HyperPSCA: A Unified Autopoietic Hypergraph Engine for Cross-Domain Scientific Discovery, Patent Screening, and Material/Biomedical Co-Evolution
  🇬🇧 English Version Title HyperPSCA: A Unified Autopoietic Hypergraph Engine for Cross-Domain Scientific Discovery, Patent Screening, and Material/Biomedical Co-Evolution Description/Abstract This repository introduces the computational infrastructure of Hype…
  datacite Usai, Luigi 2026 置信度 0.66 pscaparadigma sardo corsoparadigma sardo corso atlantideoLuigi UsaiUsai Luigi