合成生物与生物制造 · 全部实体（第 68 / 100 页）

本页收录第 6701–6800 条，共 10000 条 · 返回 合成生物与生物制造 首页

• A Quarter-Century of Synthetic Data in Healthcare: Unveiling Trends with Structural Topic Modeling
  Data-driven approaches are transforming healthcare, yet acquisition of comprehensive datasets is hindered by high costs, privacy regulations, and ethical concerns. To address these challenges, synthetic data, artificially generated datasets that mimic the stat…
  preprints 2025 置信度 0.74
• Low concentrations of tetrasodium EDTA cause significant killing of biofilm-associated <i>P. aeruginosa</i> in high validity models of chronic wound and CF lung infections – but not in a model of endotracheal tube colonisation
  preprints 2025 置信度 0.74
• Learning gene interactions from tabular gene expression data using Graph Neural Networks
  preprints 2026 置信度 0.74
• Defining the chromatin-associated protein landscapes on <i>Trypanosoma brucei</i> repetitive elements using synthetic TALE proteins
  preprints 2025 置信度 0.74
• Animal collocation analysis 2.0: improving statistical inference and applications for cohort comparisons
  preprints 2026 置信度 0.74
• Billion-Scale Deciphering of Human Gene Regulatory Grammar
  Predicting how DNA sequence specifies gene expression remains a core challenge across regulatory genomics. Most predictive assays and models depend on native genomic DNA, constraining the full biochemical engineering space for assessing and designing new seque…
  preprints 2025 置信度 0.74
• Strong promoters are mutationally robust
  preprints 2025 置信度 0.74
• Uncovering the mechanism of action of a historical antimicrobial against <i>S. aureus</i> and <i>A. baumannii</i>
  preprints 2026 置信度 0.74
• Single Domain Antibody Inhibitors Target the Coiled Coil Arms of the <i>Bacillus subtilis</i> SMC complex
  Synthetic nanobodies—also called sybodies—have proven valuable for stabilizing conformations of purified proteins, advancing structural and functional studies for example of transmembrane protein complexes. However, their utility in modulating protein function…
  preprints 2025 置信度 0.74
• A natural history of AMR in <i>Klebsiella pneumoniae</i> : Global diversity, predictors, and predictions of evolutionary pathways
  preprints 2025 置信度 0.74
• Substrate scope and catalytic mechanism of α, β-epoxyketone synthase EpnF illuminated by <i>in situ</i> esterase-mediated deprotection
  preprints 2025 置信度 0.74
• Boltz-2: Towards Accurate and Efficient Binding Affinity Prediction
  Accurately modeling biomolecular interactions is a central challenge in modern biology. While recent advances, such as AlphaFold3 and Boltz-1, have substantially improved our ability to predict biomolecular complex structures, these models still fall short in …
  preprints 2025 置信度 0.74
• Dynamics of genetic circuits in <i>Pseudomonas protegens</i>
  Abstract The engineering of genetic circuits to perform predefined computations is central to synthetic biology, enabling living cells with new functionalities applicable across various domains. However, these circuits are often specifically tailored to partic…
  preprints Juan Rico, Pablo Japón, Luis Rubio, Ángel Goñi-Moreno 2024 置信度 0.74
• Magnitude of biome shifts over the last 21,000 years reveals the impact of seasonality and intense warming on future vegetation
  preprints 2026 置信度 0.74
• A tRNA-gRNA multiplexing system for CRISPR genome editing in <i>Marchantia polymorpha</i>
  preprints 2025 置信度 0.74
• Stable transformation of <i>Micractinium conductrix</i> SAG 241.80: New tools for exploring photosymbiotic interactions
  preprints 2026 置信度 0.74
• Engineering prolyl hydroxylase-dependent proteolysis enables the orthogonal control of hypoxia responses in plants
  preprints 2024 置信度 0.74
• Rational modulation of plant root development using engineered cytokinin regulators
  preprints 2024 置信度 0.74
• A Linear Mixed Effects Model for Evaluating Synthetic Gene Circuits
  A significant advancement in synthetic biology is the development of synthetic gene circuits with predictive Boolean logic. However, there is no universally accepted or applied statistical test to analyze the performance of these circuits. Many basic statistic…
  preprints Gina Partipilo, Sarah M Coleman, Yang Gao, Ismar E Miniel Mahfoud 等 2024 置信度 0.74
• QSAR-Guided Generative Framework for the Discovery of Synthetically Viable Odorants
  Abstract The discovery of novel odorant molecules is key for the fragrance and flavor industries, yet efficiently navigating the vast chemical space to identify structures with desirable olfactory properties remains a significant challenge. Generative artifici…
  preprints 2026 置信度 0.74
• Engineering cell fate with adaptive feedback control
  Engineering cell fate is fundamental for optimizing stem cell-based therapies aimed at replacing cells in patients suffering from trauma or disease. By timely administering molecular regulators - such as transcription factors, RNAs, or small molecules - in a p…
  preprints Frank Britto Bisso, Giulia Giordano, Christian Cuba Samaniego 2024 置信度 0.74
• An Aggregation Prone Region (APR) in talin controls talin self-interactions to regulate integrin adhesion complex dynamics
  The tight regulation of the integrin family of extracellular matrix (ECM) receptors is essential for the coordination of most cellular processes. Talin regulates integrin function by binding to the cytoplasmic tail of the integrin beta subunit. Two integrin-bi…
  preprints 2026 置信度 0.74
• Priority effects determine community composition at the strain level in the honeybee gut microbiota
  preprints 2025 置信度 0.74
• ON-OFF nanopores for optical control of transmembrane ionic communication
  preprints 2024 置信度 0.74
• Explainable Generative AI Uncovers a Molecular Continuum in Medulloblastoma with Implications for Rare Cancer Subtyping and Treatment Equity
  preprints 2024 置信度 0.74
• The role of the nuclear pore complex in the stability of disease-related short tandem DNA repeats
  preprints 2026 置信度 0.74
• Return of the GEDAI: Unsupervised EEG Denoising based on Leadfield Filtering
  preprints 2025 置信度 0.74
• Monitoring in vivo transcription with synthetic serum markers
  preprints 2024 置信度 0.74
• <i>Cryptococcus neoformans</i> employs both PP1 and PP2A phosphatases to silence the spindle checkpoint
  preprints 2025 置信度 0.74
• Alcohol dehydrogenase-mediated methanol dissimilation increases carbon efficiency in synthetic autotrophic yeast
  preprints 2026 置信度 0.74
• Engineered Receptors for Soluble Cell-to-Cell Communication
  preprints 2024 置信度 0.74
• Advances in Natural Product-Based Fluorescent Agents and Synthetic Analogues for Analytical and Biomedical Applications, Including Tumor Cell Labeling and Cancer Research
  preprints 2024 置信度 0.74
• TRPM2 couples cell-autonomous type-I interferon signaling to pigmentation homeostasis
  preprints 2026 置信度 0.74
• Structural and functional characterisation of a reconstructed ancestral strigolactone receptor
  preprints 2025 置信度 0.74
• Efficient <i>in vitro</i> refactoring and biosynthetic gene cluster amplification for the overproduction and accelerated discovery of anticancer thioamitides
  preprints 2026 置信度 0.74
• Damselflies Overcome Color Saturation Barriers of Photonic Glasses <i>via</i> Structural Dispersion and Pigment Loading
  preprints 2025 置信度 0.74
• WormTagDB: A Systematic Survey of Endogenously Tagged Proteins in C. elegans and Roadmap Towards the Tagged Proteome
  preprints 2025 置信度 0.74
• Elucidating the metabolic roles of isoflavone synthase-mediated protein-protein interactions in yeast
  Abstract Transient plant enzyme complexes formed via protein-protein interactions (PPIs) play crucial regulatory roles in secondary metabolism. Complexes assembled on cytochrome P450s (CYPs) are challenging to characterize metabolically due to difficulties in …
  preprints Chang Liu, Jianing Han, Sijin Li 2024 置信度 0.74
• Cytokinin overcomes spikelet-driven inhibition of tillering in wheat and barley by delaying meristem development
  preprints 2025 置信度 0.74
• Engineering a Biosynthetic Pathway for the Production of (+)-Brevianamides A and B in <i>Escherichia coli</i>
  preprints 2024 置信度 0.74
• Prodan-based solvatochromic probes for polarity imaging of organelles
  preprints 2025 置信度 0.74
• Functional Post-Synthetic Chemistry of Metal-Organic Cages According to Its Molecular Architecture and Specific Geometry of Origin
  preprints 2024 置信度 0.74
• Towards a Better Control of Engineered Circuit Expression in Bacterial Genomes
  The expression of genes and engineered circuits can deeply vary when inserted into different genomic loci. This unpredictable performance of expression, termed context sensitivity, complicates strain development. Although the causes and mechanisms of context s…
  preprints 2024 置信度 0.74
• Cytosolic Ca ²⁺ as a universal signal for rapid root growth regulation
  preprints 2025 置信度 0.74
• Differential Burst dynamics of Slow and Fast gamma rhythms in Macaque primary visual cortex
  preprints 2025 置信度 0.74
• Silaffins-Driven Genetic Engineering of Diatom Cell Walls: Insight into Biosilica Morphology and Nanomaterial Design
  preprints 2024 置信度 0.74
• Disordered Peptide-Based Design of Intrinsically Disordered Polymers for Biomedical Applications
  preprints 2024 置信度 0.74
• Effects of multistability, absorbing boundaries and growth on Turing pattern formation
  preprints 2024 置信度 0.74
• Leveraging Synthetic Virology for the Rapid Engineering of Vesicular Stomatitis Virus (VSV)
  Abstract Vesicular stomatitis virus (VSV) is a prototype RNA virus that has been instrumental in advancing our understanding of viral molecular biology and has applications in vaccine development, cancer therapy, antiviral screening, and more. Current VSV geno…
  preprints Chad M. Moles, Rupsa Basu, Peter Weijmarshausen, Brenda Ho 等 2024 置信度 0.74
• Cell extract-based in vitro DNA replication enables sustainable cell-free gene expression
  preprints 2024 置信度 0.74
• Model-guided gene circuit design for engineering genetically stable cell populations in diverse applications
  Abstract Maintaining engineered cell populations’ genetic stability is a key challenge in synthetic biology. Synthetic genetic constructs compete with a host cell’s native genes for expression resources, burdening the cell and impairing its growth. This create…
  preprints Kirill Sechkar, Harrison Steel 2024 置信度 0.74
• Structures and molecular mechanisms of RAD54B in modulating homologous recombination
  Summary Genome stability is essential for cellular viability yet constantly threatened by endogenous and exogenous DNA-damaging agents. Among these, DNA double-strand breaks (DSBs) are particularly harmful and in S/G2 phases are faithfully repaired through hom…
  preprints 2026 置信度 0.74
• Making Neurobots and Chimerical Ctenophores
  preprints 2024 置信度 0.74
• Spectral algal fingerprinting and long sequencing in synthetic algal-microbial communities
  preprints 2024 置信度 0.74
• Concentration dependent CsrA regulation of the <i>uxuB</i> transcript leads to development of post-transcriptional BANDPASS Filter
  Post-transcriptional control systems offer new avenues to design synthetic circuits that offer reduced burden and less synthetic regulatory components compared to transcriptionally based tools. Herein, we repurpose a newly identified post-transcriptional inter…
  preprints 2024 置信度 0.74
• Engineering synthetic signaling receptors to enable erythropoietin-free erythropoiesis
  preprints 2024 置信度 0.74
• Self-Authenticating Genomic Materials with Advanced Genome Signatures
  preprints 2024 置信度 0.74
• Entirely synthetic memory inception via dual optogenetic activation of sensory and dopaminergic neurons
  Summary Associative conditioning is a fundamental learning paradigm that links salient stimuli to appropriate behavior. The vinegar fly is an important memory model that can associate odors with rewarding or punishing reinforcement stimuli via distinct sets of…
  preprints 2025 置信度 0.74
• Sleeping Through Menopause: study protocol of a randomized controlled trial of menopausal hormone therapy and online guided cognitive behavioural and circadian therapy for insomnia in perimenopausal women suffering from insomnia
  ABSTRACT Background About half of the women experience insomnia during the perimenopause, a transitional phase characterised by fluctuations in sex hormones. Insomnia is known to increase the risk of other mental health problems. Therefore, addressing insomnia…
  preprints 2026 置信度 0.74
• CryptKeeper: a negative design tool for reducing unintentional gene expression in bacteria
  Abstract Foundational techniques in molecular biology—such as cloning genes, tagging biomolecules for purification or identification, and overexpressing recombinant proteins—rely on introducing non-native or synthetic DNA sequences into organisms. These sequen…
  preprints Cameron T. Roots, Jeffrey E. Barrick 2024 置信度 0.74
• Conserved dimerization architecture in C-type lectins from virus-vector mosquitoes
  C-type lectins (CTLs) play key roles in innate immunity and microbial carbohydrate recognition. In the disease vector mosquito Aedes aegypti , the CTLD-S family comprises 34 soluble CTLs whose members are implicated in flavivirus dissemination and microbial ho…
  preprints 2026 置信度 0.74
• Direct high-throughput deconvolution of unnatural bases via nanopore sequencing and bootstrapped learning
  preprints 2024 置信度 0.74
• A subject-specific reversible folding model reveals geometry-driven white-matter organization
  Tractography currently relies almost exclusively on diffusion data and seed maps, which alone remain insufficient for anatomically accurate fiber reconstruction. During brain development, white-matter fibers elongate alongside cortical folding, suggesting a cl…
  preprints 2025 置信度 0.74
• Accurate and General DNA Representations Emerge from Genome Foundation Models at Scale
  preprints 2024 置信度 0.74
• Global comparative structural analysis of responses to protein phosphorylation
  preprints 2024 置信度 0.74
• Advanced Technologies for Marine Drugs Large Scale Supply
  preprints 2024 置信度 0.74
• Size Selection of Giant Unilamellar Vesicles (GUVs) via Modified cDICE Method
  preprints 2024 置信度 0.74
• Engineering programmable CAR-T cells with tunable controls as fail-safe mechanisms during cancer immunotherapy
  preprints 2024 置信度 0.74
• Dynamic regulation of engineered T7 RNA polymerases by endogenous metabolites
  preprints 2024 置信度 0.74
• PEG Adjustment Enables Genome Transplantation Using <i>Mycoplasma Mycoides</i> Recipient
  preprints 2024 置信度 0.74
• A Versatile Microfluidic Device System that Lacks a Synthetic Extracellular Matrix Recapitulates the Blood-Brain Barrier and Dynamic Tumor Cell Interaction
  preprints 2024 置信度 0.74
• Efficacy inference in early-phase non-controlled clinical trials via Bayesian biomarker deconvolution
  preprints 2026 置信度 0.74
• Stepwise and lineage-specific divergence of a major immune co-chaperone complex in leptosporangiate ferns
  preprints 2025 置信度 0.74
• Weighted sliced inverse regression for scalable supervised dimensionality reduction of spatial transcriptomics data
  With the dramatic take-up of spatially resolved transcriptomics biotechnologies, performing spatially-aware analysis of the resulting data is crucial to maximise advances in biological understanding. Dimensionality reduction is a first step in almost any analy…
  preprints 2025 置信度 0.74
• Humanized Caffeine-Inducible Systems for Controlling Cellular Functions
  preprints 2025 置信度 0.74
• The Use of Hydroxynitrile Lyases (HNLs) for Stereospecific Synthesis of Esters, Alcohols, and Acids
  preprints 2024 置信度 0.74
• Machine learning-led semi-automated medium optimization reveals salt as key for flaviolin production in Pseudomonas putida
  preprints 2024 置信度 0.74
• Baicalin ameliorates behavioral and physiological deficits in <i>Gtf2i</i> -duplication mice and modulates synaptic activity in 7q11.23 Duplication Syndrome patient-derived neurons
  preprints 2026 置信度 0.74
• Intravital imaging uncovers remodelling of humanised bone marrow-like niches
  preprints 2026 置信度 0.74
• Modanovo: A Unified Model for Post-Translational Modification-Aware de Novo Sequencing Using Experimental Spectra from In Vivo and Synthetic Peptides
  preprints 2025 置信度 0.74
• Turncoat antibodies unmasked in a model of autoimmune demyelination: from biology to therapy
  preprints 2024 置信度 0.74
• MATRIX: Rapid Quantification of Total and Active Microbial Cells with Single-Cell Phenotypes for Environmental Microbiomes
  Quantifying the abundance and activity of bacteria within populations and communities is fundamental to systems microbiology and microbiome research. Yet direct microscopic cell counting remains low-throughput, labor-intensive, and prone to user variability, l…
  preprints 2026 置信度 0.74
• Cap-adjacent 2’- <i>O</i> -ribose methylation of RNA in <i>C. elegans</i> is required for postembryonic growth and germline development in the presence of the decapping exonuclease EOL-1
  preprints 2025 置信度 0.74
• DNA synthesis and assembly technologies: from oligonucleotides to complete genomes
  preprints 2024 置信度 0.74
• Biological oscillations without genetic oscillator or external forcing
  preprints 2024 置信度 0.74
• Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains
  preprints 2025 置信度 0.74
• KinPFN: Bayesian Approximation of RNA Folding Kinetics using Prior-Data Fitted Networks
  preprints 2024 置信度 0.74
• Metaproteomics Reveals Functional Rewiring and Metabolic Limits in Synthetic Bacterial Consortia Degrading Complex Waste Oils
  preprints 2026 置信度 0.74
• A Naïve RNA Sampling Core Enables Adaptive piRNA Specificity Against Transposable Elements
  ABSTRACT How piRNA-mediated genome defense achieves specificity against transposons while sampling a complex transcriptome has remained unresolved. Here we show that piRNA biogenesis operates through pervasive, non-specific sampling of cytoplasmic RNAs, with s…
  preprints 2026 置信度 0.74
• A haplotype-complete chromosome-level assembly of octoploid Urochloa humidicola cv. Tully reveals multiple genomic compositions and evolutionary histories in the species
  We developed a haplotype-resolved, chromosome-scale genome assembly of the Urochloa humidicola (Rendle) Morrone & Zuloaga cultivar Tully, an apomictic C4 forage grass cultivated in the tropics worldwide. We assembled a 4.1 Gb genome into 48 chromosomes (2n = 8…
  preprints 2025 置信度 0.74
• Inverted topographies in sequential fitness landscapes enable evolutionary control
  preprints 2024 置信度 0.74
• Assessing the Validity of Leucine Zipper Constructs Predicted in AlphaFold2
  AP-1 transcription factors are a network of cellular regulators, that combine in different dimer pairs to control a range of pathways involved in differentiation, growth, and cell death. They dimerise via leucine zipper coiled-coil domains, that are preceded b…
  preprints 2024 置信度 0.74
• ppLM-CO:Pre-trained Protein Language Model for Codon Optimization
  preprints 2024 置信度 0.74
• Tertiary Structures of Haseki Tick Virus Nonstructural Proteins Are Similar to Those of Orthoflaviviruses
  preprints 2024 置信度 0.74
• Risk-averse optimization of genetic circuits under uncertainty
  Abstract Synthetic biology aims to engineer biological systems with specified functions. This requires navigating an extensive design space, which is challenging to achieve with wet lab experiments alone. To expedite the design process, mathematical modelling …
  preprints Michal Kobiela, Diego A. Oyarzún, Michael U. Gutmann 2024 置信度 0.74
• Specialisation of meiotic kinetochores revealed through a synthetic spindle assembly checkpoint strategy
  preprints 2025 置信度 0.74
• A Guide to the Multidimensional Nature of Biological Information: Of Maxwell’s and Other Demons
  preprints 2024 置信度 0.74
• Fundamental trade-offs in the robustness of biological systems with feedback regulation
  preprints 2024 置信度 0.74
• Internal Phase Separation in Synthetic DNA Condensates
  preprints 2025 置信度 0.74
• Identification and Masking of Artefactual and Misleading Within-Host Variants in Deep-Sequencing SARS-CoV-2 Data
  preprints 2026 置信度 0.74