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• Privacy-, linguistic-, and information-preserving synthesis of clinical documentation through generative agents.
  The widespread adoption of generative agents (GAs) is reshaping the healthcare landscape. Nonetheless, broad utilization is impeded by restricted access to high-quality, interoperable clinical documentation from electronic health records (EHRs) due to persiste…
  europepmc 2025 置信度 0.80
• AgroNova: An Autonomous IoT Platform for Greenhouse Climate Control.
  This study presents AgroNova-a hybrid IoT architecture for autonomous monitoring and management of microclimate in greenhouse environments. The system combines a capillary wireless sensor network, gateway-level rule-based agents, a server agent, cloud services…
  europepmc 2026 置信度 0.80
• From Prompt to Drug: Toward Pharmaceutical Superintelligence.
  The convergence of generative artificial intelligence (AI) platforms and automated laboratory systems is ushering in a new era of drug discovery, in which a plain-language prompt can initiate a fully autonomous, end-to-end drug development program. This articl…
  europepmc 2026 置信度 0.80
• Unraveling the mysteries of the gut-kidney axis: the protective role of traditional Chinese medicine in chronic kidney disease.
  Chronic kidney disease (CKD) constitutes a globally progressive nephropathy orchestrating inexorable deterioration of renal architecture. The paradigmatic gut-kidney axis unveils sophisticated bidirectional interplay between enteric microbiome and renal homeos…
  europepmc 2025 置信度 0.80
• AI-Augmented Co-Design in Healthcare: Log-Based Markers of Teamwork Behaviors and Collective Intelligence Outcomes.
  Co-design in healthcare settings requires teams to utilize each other's knowledge effectively, but practical guidance and simple methods for observing collaboration are often lacking. We tested whether a lightweight AI assistant that guides the process-and aut…
  europepmc 2025 置信度 0.80
• Architectures, Protocols and Algorithms of Sensor Networks-Second Edition.
  Sensor networks have become a background technology for a wide range of applications in industrial automation, smart cities, intelligent transportation systems, healthcare monitoring, environmental sensing, precision agriculture, and supervision of critical in…
  europepmc 2026 置信度 0.80
• PKGPT: Expert-Orchestrated Recursive LLM Agent for Automated NONMEM PopPK Modeling with Human Benchmarking.
  Background/Objectives: Population pharmacokinetic (PopPK) modeling in NONMEM requires iterative, expertise-dependent workflows. Naïve zero-shot prompting of general-purpose large language models (LLMs) typically produces NONMEM code that fails to execute. This…
  europepmc 2026 置信度 0.80
• The Paradox in AI Influencer Engagement: A Dual Path to Psychological Need Satisfaction and Frustration.
  As AI-generated influencers increasingly dominate social media landscapes, their psychological impact on human users necessitates rigorous empirical investigation. Grounded in Self-Determination Theory, this study examines how AI influencers influence the sati…
  europepmc 2026 置信度 0.80
• Secure quantum-resilient smart city communication networks using QSC-Net with MF-MBO-based energy-aware task scheduling.
  Adaptable optimisation that preserves efficiency under time-varying system dynamics necessitates modern task management in innovative city development and in distributed edge-cloud computing systems. Conservative optimisation techniques such as genetic algorit…
  europepmc 2026 置信度 0.80
• A Novel Orchestrator Architecture for Deploying Virtualized Services in Next-Generation IoT Computing Ecosystems.
  The Next-Generation IoT integrates diverse technological enablers, allowing the creation of advanced systems with increasingly complex requirements and maximizing the use of available IoT-edge-cloud resources. This paper introduces an orchestrator architecture…
  europepmc 2025 置信度 0.80
• EPRS: Experience-Prioritized Reinforcement Scheduler in Edge Clusters.
  Edge computing has garnered significant attention in recent years due to its potential in distributed systems. However, the dynamic and heterogeneous nature of edge environments introduces substantial challenges for task scheduling. Conventional rule-based sch…
  europepmc 2026 置信度 0.80
• The Test Pyramid 2.0: AI-assisted testing across the pyramid.
  Ensuring robust test coverage, high code quality, and a strong security posture are persistent challenges in modern industrial software development, especially as systems grow in complexity and release cycles accelerate with recent Artificial Intelligence (AI)…
  europepmc 2025 置信度 0.80
• Thinking outside the library: cluster synthesis of diverse molecules on a single robotic platform.
  The development of a general autonomous platform for organic synthesis that enables faster, flexible and efficient delivery of target molecules is an attractive strategy for many fields such as drug discovery and materials science. Traditionally, automated par…
  europepmc 2026 置信度 0.80
• On the potential of agentic workflows for animal training plan generation.
  Effective animal training depends on well-structured training plans that ensure consistent progress and measurable outcomes. However, the creation of such plans is often time-intensive, repetitive, and detracts from hands-on training. Recent advancements in ge…
  europepmc 2025 置信度 0.80
• Adenosine Signaling in Primary and Metastatic Brain Tumors: Immune Suppression, Tumor Progression, and Therapeutic Opportunities.
  Brain tumors, whether primary or metastatic, remain a significant cause of cancer-related mortality and are characterized by a profoundly immunosuppressive tumor microenvironment (TME). Among the signaling pathways that shape this environment, purinergic signa…
  europepmc 2026 置信度 0.80
• KT-LLM: an evidence-grounded and sequence text framework for auditable kidney transplant modeling.
  We address a critical clinical gap in real-world kidney transplantation (KT), the long-standing disconnect between structured longitudinal follow-up and text-defined clinical rules, which often leads to inconsistent reporting, poor policy compliance, and non-r…
  europepmc 2026 置信度 0.80
• Empowerment or dependency? A systematic review of the impacts of intelligent assessment and generative AI on learners' self-beliefs and cognitive agency in music education.
  Although artificial intelligence is fundamentally reshaping the ecology of music learning, existing research has disproportionately emphasized performance outcomes while underexamining psychological mechanisms, leaving the tension between technological empower…
  europepmc 2026 置信度 0.80
• Managing human-AI collaborations within Industry 5.0 scenarios via knowledge graphs: key challenges and lessons learned.
  In this paper, we discuss technologies and approaches based on Knowledge Graphs (KGs) that enable the management of inline human interventions in AI-assisted manufacturing processes in Industry 5.0 under potentially changing conditions in order to maintain or …
  europepmc 2024 置信度 0.80
• LLM-driven collaborative framework for knowledge-enhanced cancer pain assessment and management.
  Due to its multi-factor mechanism, variable opioid response, and high-risk adverse reactions, cancer pain remains a major challenge in oncology. To overcome these obstacles, we have developed a collaboration framework based on large language models (LLMs): Onc…
  europepmc 2026 置信度 0.80
• Design of an AI-driven secure 5G-SDN framework with federated reinforcement learning for anomaly detection, mitigation, and attack forensics.
  Introduction The increasing adoption of Software-Defined Networking (SDN) in 5G networks has revolutionized network management. However, this paradigm shift has introduced critical security vulnerabilities, including data-plane anomalies, control-layer intrusi…
  europepmc 2026 置信度 0.80
• Digitalization and organizational capabilities: a mechanism-based integrative review.
  Purpose This study addresses the fragmented understanding of how digitalization shapes organizational capabilities by identifying and synthesizing the underlying mechanisms. Methods A mechanism-based systematic literature review was conducted on 116 core studi…
  europepmc 2026 置信度 0.80
• Beyond the Genomic Storm: Evaluating Tabernanthalog as a Potential Scaffold for Silent Neuroplasticity and Broad-Spectrum Therapy.
  The clinical renaissance of psychedelic medicine has highlighted the therapeutic potential of rapid-acting neuroplastogens, or "psychoplastogens," for psychiatric disorders. However, the widespread application of classical psychedelics-such as psilocybin and L…
  europepmc 2026 置信度 0.80
• A method to promote safe cycling powered by large language models and AI agents.
  This paper presents a novel information generation methodology to support safer cycling patterns in urban environments, leveraging for that Large Language Models (LLMs), AI-based agents, and open geospatial data. By processing multiple files containing previou…
  europepmc 2024 置信度 0.80
• Integrating emotional intelligence, memory architecture, and gestures to achieve empathetic humanoid robot interaction in an educational setting.
  This study investigates the integration of individual human traits into an empathetically adaptive educational robot tutor system designed to improve student engagement and learning outcomes with corresponding Engagement Vector measurements. While prior resear…
  europepmc 2025 置信度 0.80
• Research on reliability mapping of 5G low orbit constellation network slice based on deep reinforcement learning.
  Reliability mapping of 5G low orbit constellation network slice is an important means to ensure link network communication. The problem of state space explosion is a typical problem. The deep reinforcement learning method is introduced. Under the 5G low orbit …
  europepmc 2024 置信度 0.80
• A Review of Agentic AI in Cybersecurity: Cognitive Autonomy, Ethical Governance, and Quantum-Resilient Defense.
  Agentic Artificial Intelligence (AAI) refers to autonomous, adaptable, and goal-directed systems capable of proactive decision-making in dynamic environments. These agentic systems extend beyond reactive AI by leveraging cognitive architectures and reinforceme…
  europepmc 2025 置信度 0.80
• Protocol-Driven Multi-Agent Orchestration for Federated Distributed Analytics
  crossref Soumyodeep Mukherjee 2026-08-10T19:13:18Z 置信度 0.70
• Asset Lifecycle Information Orchestration in Process Systems Engineering
  This thesis explores the application of a holistic data integration approach with a focus on common planning objects in the process industry. The hypothesis posits that this approach can improve the quantity and quality of mapping relations between data models…
  crossref Michael Wiedau 2024-12-13T08:06:21Z 置信度 0.70
• Adaptive Orchestration with Cross-Episode Memory for Dynamic LLM-based Agent Pools
  Multi-agent systems are moving toward open ecosystems in which agents may appear, change, or disappear at runtime.Orchestrators must therefore discover relevant black-box specialists from large pools and learn how to coordinate them across repeated tasks.Exist…
  crossref Marleen Lukei, Philine Thalia Kowol 2026-08-12T10:31:13Z 置信度 0.70
• The Technique of Orchestration
  The Technique of Orchestration, Seventh Edition, is the definitive textbook on the study of orchestration, offering a concise, straight-to-the-point approach that prepares students to score their own compositions with confidence. Updated to reflect development…
  crossref Kent Kennan, Donald Grantham 2024-04-12T11:20:24Z 置信度 0.70
• Real-Time Micro-Fulfillment Orchestration in Omnichannel Retail Using Multi-Agent Reinforcement Learning Framework
  Micro-fulfillment centers (MFCs) have emerged as a response to growing e-commerce demands, yet their integration into omnichannel retail networks creates order routing challenges that traditional optimization struggles to solve efficiently. This paper introduc…
  crossref Sri Harsha Konda 2025-12-19T15:35:36Z 置信度 0.70
• G-MAO: Gaze-Grounded Multi-Agent Orchestration for XR Document Understanding
  crossref YunSu Lee, Seungwon Kim 2026-08-06T19:14:28Z 置信度 0.70
• The Technique of Orchestration Workbook
  The Technique of Orchestration Workbook, Seventh Edition, accompanies the textbook of the same name—the definitive resource on the study of orchestration—providing musical excerpts, full scores, and scoring assignments to enrich the lessons learned in the text…
  crossref Kent Kennan, Donald Grantham 2024-04-11T14:47:55Z 置信度 0.70
• HARMONIC: Hierarchical Adaptive Resilience via Multi-agent Orchestration in Networked Intelligent Computing for SDN-Enhanced Fog-Edge Systems
  The rapid proliferation of ultra-low-latency distributed services-ranging from autonomous driving and industrial metaverse to real-time telemedicine-has exposed critical shortcomings in conventional cloud-centric resource management paradigms. Although the fus…
  crossref Tan Wei Liang, Yamamoto Kenji, Park Min-Jae, Zhang Jianping 2026-08-18T16:38:09Z 置信度 0.70
• Orchestration
  Whilst Richard Wagner has long been acknowledged as one of the central figures in the history of orchestration, his treatment of the orchestra has only rarely received scholarly attention. This chapter uses a series of analytical vignettes to examine Wagner’s …
  crossref Edward Reeve 2024-03-14T00:12:08Z 置信度 0.70
• Transforming Public Administration Workflows with Multi-Agent AI: A Human-in-the-Loop Knowledge Orchestration Framework
  Public administrations face increasing pressure to manage large volumes of institutional knowledge while ensuring transparency, accountability, and timely responses to citizen and council inquiries. This paper presents CARE (Council Agents for Response and Eng…
  crossref Giuseppe Prencipe, Alessandro Tommasi, Cesare Zavattari, Giovacchino Tesi 等 2026-02-25T04:45:44Z 置信度 0.70
• Introduction
  The terms instrumentation and orchestration are sometimes used synonymously. It seems best, however, to make the following distinction between them: instrumentation generally refers to a study of individual instruments—such aspects as their construction, histo…
  crossref Kent Kennan, Donald Grantham 2024-04-12T11:20:24Z 置信度 0.70
• Bibliography
  crossref Michael Wiedau 2024-12-13T08:06:21Z 置信度 0.70
• 1. Introduction
  crossref Michael Wiedau 2024-12-13T08:06:21Z 置信度 0.70
• The Percussion
  Chapter 13 covers percussion instruments, which provide the “characteristic sound” of a good deal of recent music. Composers consider that section equal in importance to the other sections of the orchestra. Described in this chapter are the most common and fre…
  crossref Kent Kennan, Donald Grantham 2024-04-12T11:20:24Z 置信度 0.70
• Titelei/Inhaltsverzeichnis
  crossref Michael Wiedau 2024-12-13T08:06:21Z 置信度 0.70
• Effectiveness of AI/ML in SOAR (Security Automation and Orchestration) Platforms
  Security Operations Centres (SOCs) are consistently confronted with an ongoing challenge posed by the evolution of cyber threats. Security Automation and Orchestration (SOAR) platforms have effectively tackled this challenge through the optimization of workflo…
  crossref Srihari Subudhi 2024-08-05T12:15:16Z 置信度 0.70
• Harp
  Rewrite the following passages for harp in such a way as to involve the fewest possible pedal changes. Do not omit notes but change spellings where that will eliminate pedal changes. Include a pedal setting at the beginning of each exercise and indicate pedal …
  crossref Kent Kennan, Donald Grantham 2024-04-11T14:47:55Z 置信度 0.70
• Percussion
  Write a part for four timpani. For the initial tuning, try to select pitches that will fit into the harmonies throughout the piece (at the points where timpani are being used). If changes in tuning are felt to be necessary, remember to allow at least three or …
  crossref Kent Kennan, Donald Grantham 2024-04-11T14:47:55Z 置信度 0.70
• The Woodwinds
  This chapter delves into the woodwinds section, consisting of the following instruments: the flute, the piccolo, the alto flute, the oboe, the English horn, the clarinet, the bass clarinet, the E♭ clarinet, the bassoon, and the contrabassoon. Ranges (possible …
  crossref Kent Kennan, Donald Grantham 2024-04-12T11:20:24Z 置信度 0.70
• The Percussion
  Chapter 14 discusses instruments of indefinite pitch. It covers the commonly used rudimental strokes, the various ways of playing each instrument, the special capabilities of each instrument, and each instrument s proper notation.
  crossref Kent Kennan, Donald Grantham 2024-04-12T11:20:24Z 置信度 0.70
• Brass
  Below each of the following excerpts from orchestral horn and trumpet parts write the passage as it will actually sound. Include a key signature except in the case of the Strauss and Scriabin examples. This exercise does not attempt to exhaust all the key poss…
  crossref Kent Kennan, Donald Grantham 2024-04-11T14:47:55Z 置信度 0.70
• The Strings
  Chapter 2 covers elementary material on the individual stringed instruments: the violin, the viola, the violincello (cello), and the double bass. It should be apparent, even from this brief discussion, that writing for strings is a special technique. What look…
  crossref Kent Kennan, Donald Grantham 2024-04-12T11:20:24Z 置信度 0.70
• Special Devices
  Chapter 17 comments on special devices or considerations involved in scoring for orchestral groups in general. It covers extreme registers, unusual spacing, special dynamic arrangements, the emphasis on colors and textures, divisions of the orchestra into two …
  crossref Kent Kennan, Donald Grantham 2024-04-12T11:20:24Z 置信度 0.70
• Smart AI-Enabled Orchestration for Resource Optimization in the Cloud Environment
  This study explores the integration of AIdriven techniques into cloud orchestration, emphasizing the transformative impact on resource optimization, automation, and scalability. The paper presents realworld case studies across industries, highlighting the bene…
  crossref Rajashekhar Reddy Kethireddy 2024-10-05T12:16:02Z 置信度 0.70
• Strings
  Score one of the excerpts below (as specified by the instructor) for strings in six different ways. Use Examples 3.3–3.6 and 3.8–3.11 in Chapter 3 of the text as general models. It is not necessary to rewrite the clef, key signature, meter signature, or tempo …
  crossref Kent Kennan, Donald Grantham 2024-04-11T14:47:55Z 置信度 0.70
• Orchestra
  Score for woodwinds, horns, and strings, plus percussion—and harp, if desired. Meter changes must be inserted at the actual measures where they occur. This piece is also suitable for an assignment in scoring for strings alone.
  crossref Kent Kennan, Donald Grantham 2024-04-11T14:47:55Z 置信度 0.70
• Woodwinds
  These exercises involve two types of transposition. In some cases the actual (concert) sounds are given, and the passage is to be notated in transposed form on the staff above it, with the appropriate key signature. In other cases, the passage is given as it a…
  crossref Kent Kennan, Donald Grantham 2024-04-11T14:47:55Z 置信度 0.70
• The Horn
  Chapter 7 explores all aspects of the horn, covering: the extreme possible range of the horn and the usual ranges of horns I and III and horns II and IV; transpositions (including the old system of notation in the bass clef); differences between the old natura…
  crossref Kent Kennan, Donald Grantham 2024-04-12T11:20:24Z 置信度 0.70
• Load-Aware Container Orchestration on Kubernetes Clusters
  crossref Angelo Marchese, Orazio Tomarchio 2024-05-06T16:53:02Z 置信度 0.70
• The Brass Section
  Chapter 9 discusses the brass section, which, for purposes of illustration here, is the average one: four horns, two or three trumpets, three trombones, and tuba. The chapter discusses arrangement of instruments on page (order and grouping), principles of bala…
  crossref Kent Kennan, Donald Grantham 2024-04-12T11:20:24Z 置信度 0.70
• Towards a Communication Specification Language for Heterogeneous Service Orchestration Based on Process Calculus and Holonic Multi-agent Systems
  crossref Markus Schatten, Tomislav Peharda, Bogdan Okreša Ɖurić 2024-11-19T16:42:42Z 置信度 0.70
• Reviewer #1 (Public Review): Microtubule-dependent orchestration of centriole amplification in brain multiciliated cells
  Centriole number must be restricted to two in cycling cells to avoid pathological cell divisions. Multiciliated cells (MCC), however, need to produce a hundred or more centrioles to nucleate the same number of motile cilia required for fluid flow circulation. …
  crossref 2024-05-13T12:25:58Z 置信度 0.70
• Reviewer #2 (Public Review): Microtubule-dependent orchestration of centriole amplification in brain multiciliated cells
  Centriole number must be restricted to two in cycling cells to avoid pathological cell divisions. Multiciliated cells (MCC), however, need to produce a hundred or more centrioles to nucleate the same number of motile cilia required for fluid flow circulation. …
  crossref 2024-05-13T12:25:58Z 置信度 0.70
• eLife Assessment: Microtubule-dependent orchestration of centriole amplification in brain multiciliated cells
  Centriole number must be restricted to two in cycling cells to avoid pathological cell divisions. Multiciliated cells (MCC), however, need to produce a hundred or more centrioles to nucleate the same number of motile cilia required for fluid flow circulation. …
  crossref Jens Lüders 2024-05-13T12:25:58Z 置信度 0.70
• Infrequently Used Instruments
  Chapter 18 explores infrequently used instruments, such as the saxophone, the E♭ flute, the bass flute, the oboe d’amore, the basset horn, the heckelphone, the cornet, the sarrusophone, the guitar, the mandolin, the harmonium, and many more.
  crossref Kent Kennan, Donald Grantham 2024-04-12T11:20:24Z 置信度 0.70
• Virtualized Network Functions (VNF) Orchestration and Network Routing in 5G Communication Network
  The latest wireless technology, 5G, promises increased network capacity, reduced costs, and improved energy efficiency. To achieve these benefits, businesses and service providers use advanced technologies such as Virtualized Network Functions (VNFs) and Softw…
  crossref Nipun Agarwal 2024-07-16T13:24:54Z 置信度 0.70
• Nonorchestral Instrumental Groups
  Chapter 21 provides supplementary information on other instrumental groups, groups such as the concert (symphonic) band and wind ensemble, the marching band, the jazz band, and smaller instrumental groups (chamber music).
  crossref Kent Kennan, Donald Grantham 2024-04-12T11:20:24Z 置信度 0.70
• Spatiotemporal Orchestration of Mitosis by Cyclin-Dependent Kinase
  Abstract Mitotic onset is a critical transition for eukaryotic cell proliferation. The prevailing view for its control is that cyclin-dependent kinase (CDK) is activated first in the cytoplasm, at the centrosome, which then initiates mitosis 1–3 . Bistability …
  crossref Nitin Kapadia, Paul Nurse 2024-05-02T02:05:19Z 置信度 0.70
• 5. Review, Conclusion and Outlook
  crossref Michael Wiedau 2024-12-13T08:06:21Z 置信度 0.70
• The String Orchestra
  The strings may well be considered the most important section of the orchestra for a number of reasons, and there is a good deal to be learned about combining the stringed instruments to make up a string orchestra. This chapter covers these things, along with:…
  crossref Kent Kennan, Donald Grantham 2024-04-12T11:20:24Z 置信度 0.70
• Reviewer #3 (Public Review): Microtubule-dependent orchestration of centriole amplification in brain multiciliated cells
  Centriole number must be restricted to two in cycling cells to avoid pathological cell divisions. Multiciliated cells (MCC), however, need to produce a hundred or more centrioles to nucleate the same number of motile cilia required for fluid flow circulation. …
  crossref 2024-05-13T12:25:58Z 置信度 0.70
• Bowing and Special Effects
  This chapter covers bowing and special effects. It discusses the various types of bowing and the names commonly used for them (and the indication for each), as well as the special effects obtainable on strings and the names for those. Finally, it touches on th…
  crossref Kent Kennan, Donald Grantham 2024-04-12T11:20:24Z 置信度 0.70
• Scoring Of Chords
  The following questions pertain to Example 10.13 found on pp. 181–185 of the textbook. Not all of these questions have a definitive answer. Some are intended to promote reflection and discussion.
  crossref Kent Kennan, Donald Grantham 2024-04-11T14:47:55Z 置信度 0.70
• The Woodwind Section
  Chapter 6 focuses on the instruments involved in the woodwind section in a chamber orchestra and in a full orchestra. Topics covered include the arrangement of the woodwinds on the page (order and grouping); indications for slurring, tonguing, and phrasing; pr…
  crossref Kent Kennan, Donald Grantham 2024-04-12T11:20:24Z 置信度 0.70
• Scoring for Full Orchestra
  The term scoring for full orchestra does not necessarily imply using all the instruments at once; an examination of a large number of scores would reveal that actual tuttis make up a relatively small portion of those scores. Full orchestra means only that all …
  crossref Kent Kennan, Donald Grantham 2024-04-12T11:20:24Z 置信度 0.70
• Preparing Score and Parts
  Chapter 20 explores the many aspects of preparing score and parts: what once was done by pencil, or with pen and ink (something of an artform in itself), has now been almost entirely supplanted by music software notation, such as Finale, Sibelius, and Dorico. …
  crossref Kent Kennan, Donald Grantham 2024-04-12T11:20:24Z 置信度 0.70
• Scoring for High School Orchestra
  Chapter 19 explores the challenges of scoring for the high school orchestra, discussing topics such as the ranges practical for senior and junior high/middle school orchestras, the instrumentation generally used in published arrangements for these orchestras, …
  crossref Kent Kennan, Donald Grantham 2024-04-12T11:20:24Z 置信度 0.70
• Problems in Transcribing Piano Music
  Chapter 11 discusses the problems that can occur in transcribing piano music. In scoring piano music for orchestra, the arranger often comes across certain features that are essentially pianistic rather than orchestral. In such cases a literal transcription of…
  crossref Kent Kennan, Donald Grantham 2024-04-12T11:20:24Z 置信度 0.70
• Evaluating anaesthetics for improving scientific research and welfare using larval zebrafish
  Establishing anaesthesia for ensuring both animal welfare and compatibility with protocols required for different areas of scientific research is vital. Zebrafish ( Danio rerio ) are one of the most used animal models in research; however, little is known abou…
  preprints 2025 置信度 0.74
• A rapidly prototyped, simple yet versatile dynamic breathing Exposure-on-a-Chip for investigating nanoparticle deposition in the alveoli
  We developed and characterized a three-layer microfluidic Exposure-on-a-Chip (EOC) model to replicate the alveolar microenvironment and simulate breathing motions, offering a physiologically relevant platform for studying inhaled nanomedicines. The EOC chip, f…
  preprints 2025 置信度 0.74
• Application of Decision Analytic Modelling to Cardiovascular Disease Prevention in Sub-Saharan Africa: A Systematic Review
  Abstract Background This systematic review sought to examine the application of decision analytic models (DAMs) to evaluate cardiovascular disease (CVD) prevention interventions in sub-Saharan Africa (SSA), a region which has experienced an increasing CVD burd…
  preprints 2024 置信度 0.74
• Optimal algorithms for controlling infectious diseases in real time using noisy infection data
  Deciding when to enforce or relax non-pharmaceutical interventions (NPIs) based on real-time out-break surveillance data is a central challenge in infectious disease epidemiology. Reporting delays and infection under-ascertainment, which characterise practical…
  preprints 2024 置信度 0.74
• Deep Learning for 3D Vascular Segmentation in Phase Contrast Tomography
  Abstract Automated blood vessel segmentation is critical for biomedical image analysis, as vessel morphology changes are associated with numerous pathologies. Still, precise segmentation is difficult due to the complexity of vascular structures, anatomical var…
  preprints 2024 置信度 0.74
• Neuromodulation of a peripheral nerve using fully polymeric cuff electrodes: Understanding predictability of selective stimulation
  Peripheral nerve stimulation (PNS) offers therapeutic benefits across numerous clinical applications but suffers from limitations in high resolution spatial selectivity, especially in mixed nerves. This study presents a fully polymeric, transverse, multipolar …
  preprints 2025 置信度 0.74
• Association of Long-Term Outdoor Air Pollution Exposure with Incidence of Parkinson’s Disease, Multiple Sclerosis and Motor Neuron Diseases: A Systematic Review and Meta-Analysis
  Background Parkinson’s disease (PD), multiple sclerosis (MS) and motor neurone disease (MND) are progressive and debilitating diseases that are increasing in prevalence globally. Some primary studies show an increased risk from long-term outdoor air pollution …
  preprints 2025 置信度 0.74
• AI vs. Human Buyers: A Study of Alibaba's Inventory Replenishment System
  Inventory management is one of the most important components of Alibaba’s business. Traditionally, human buyers make replenishment decisions: although AI algorithms make recommendations, human buyers can choose to ignore these recommendations and make their ow…
  preprints 2022 置信度 0.74
• Multi-omic triangulation identifies molecular candidates of atopic dermatitis severity
  Atopic dermatitis (AD) is a common skin disease with most of the health, social and economic impact driven by those with more severe disease. Determining the molecular pathways that influence severity is therefore crucial, offering opportunity to identify nove…
  preprints 2025 置信度 0.74
• Assessing PARP trapping dynamics in ovarian cancer using a CRISPR-engineered FRET biosensor
  Poly(ADP-ribose) polymerase inhibitors (PARPi) have revolutionised the treatment of ovarian high grade serous carcinoma (HGSC), especially those with defective homologous recombination. However, the emergence of resistance poses a critical challenge, as over 5…
  preprints 2025 置信度 0.74
• Public Health Events Emergency Management Supervision Strategy with Multi-agent Participation
  Abstract The outbreak of COVID-19 has once again made people realize the great danger of public health events. To cope with public health events, the central governments in many countries have established emergency management systems and took many measures inc…
  preprints 2023 置信度 0.74
• Associations of common infections with frailty and mortality in two UK cohort studies
  Background Some common infections are associated with poorer age-related health outcomes; however, findings are limited to a small number of pathogens and frequently inconclusive. This study aimed to expand the range of pathogens investigated in relation to fr…
  preprints 2025 置信度 0.74
• Hippocampus facilitates reinforcement learning under partial observability
  Mastering navigation in environments with limited visibility is crucial for survival. Although the hippocam-pus has been associated with goal-oriented navigation, its role in real-world behaviour remains unclear. To investigate this, we combined deep reinforce…
  preprints 2023 置信度 0.74
• 60 cm2 perovskite-silicon tandem solar cells with an efficiency of 28.9% by homogenous passivation
  Abstract Inverted perovskite solar cells face performance limitations due to non-radiative recombination at the perovskite surfaces in devices, including functional layers. Advanced characterization and density functional theory reveal that phosphonic acids pa…
  preprints 2025 置信度 0.74
• How will COVID-19 persist in the future? Simulating future dynamics of COVID-19 using an agent-based network model
  Despite the United States Center for Disease Control (CDC)’s May 2023 expiration of the declared public health emergency pertaining to the COVID-19 pandemic (Silk 2023), approximately 3 years after the first cases of SARS-CoV-2 appeared in the United Sates, th…
  preprints 2023 置信度 0.74
• A Platinum Butterfly Effect: Small Changes Turn an Anticancer Drug into a Non-toxic Metalloantibiotic with In Vivo Efficacy
  Widespread resistance to all clinically used antibiotics has sparked investigations into alternative sources for novel and effective antimicrobial agents. Metal-based compounds (metalloantibiotics) have emerged as a promising class of potential antibiotics exh…
  preprints 2025 置信度 0.74
• Mesenchymal stem cell-extracellular vesicles deliver microRNAs that prevent nerve growth factor-induced sensory neuron sensitization
  Osteoarthritis (OA) affects 600 million individuals globally, pain being a hallmark symptom. Emerging clinical evidence supports the use of mesenchymal stem cells (MSCs) and their extracellular vesicles (MSC-EVs) for pain relief in knee OA. In mice, MSC-EVs am…
  preprints 2026 置信度 0.74
• A Comprehensive Benchmark for COVID-19 Predictive Modeling Using Electronic Health Records in Intensive Care
  The COVID-19 pandemic highlighted the need for predictive deep learning models in healthcare. However, practical prediction task design, fair comparison and model selection for clinical applications remain a challenge. To address this, we introduced and evalua…
  preprints 2023 置信度 0.74
• QuantGUV: Quantifying Encapsulation Efficiency of Small Molecules in GUVs
  1 Synthetic cells, constructed through the self-assembly of small molecules, are designed to mimic life-like behaviours by encapsulating functional molecules. For such synthetic cells to accurately replicate cellular reactions, it is critical that the concentr…
  preprints 2025 置信度 0.74
• Chemical genetics reveals <i>Leishmania</i> KKT2 and CRK9 kinase activity is required for cell cycle progression
  Protein kinases are key regulators of the eukaryotic cell cycle and have consequently emerged as attractive targets for drug development. Their well-defined active sites make them particularly amenable to inhibition by small molecules, underscoring their drugg…
  preprints 2025 置信度 0.74
• panTB-HM: a clinical trial of a pan-TB regimen targeting both host and microbe
  Abstract Background Newer oxazolidinones will be required to advance regimens in pan-TB indications. The addition of host-directed agents may help promote the recovery of lung function during TB treatment and prevent post-TB lung disease. Methods The panTB-HM …
  preprints 2025 置信度 0.74
• Probabilistic Analysis of Agent-Based Opinion Formation Models
  When agent-based models are developed to capture opinion formation in large-scale populations, the opinion update equations often need to embed several complex psychological traits. The resulting models are more realistic, but also challenging to assess analyt…
  preprints 2023 置信度 0.74
• Long-Term Benefits of TUDCA Supplement in ARSACS Zebrafish Model
  Abstract Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS ) is an early-onset neurodevelopmental and neurodegenerative disorder characterized by ataxia, spasticity, and peripheral neuropathy. However, several studies have highlighted that some…
  preprints 2025 置信度 0.74
• Plant-Compatible Xenium <i>In Situ</i> Sequencing: Optimised Protocol for Spatial Transcriptomics in <i>Medicago truncatula</i> Roots and Nodules
  Elucidating the spatial and temporal regulation of gene expression during plant organogenesis is crucial for enabling precise crop improvement strategies that incorporate beneficial traits into crops while avoiding adverse effects. Root nodules, specialised or…
  preprints 2025 置信度 0.74
• Cohort profile: the Viral load Cohort North-East Lesotho (VICONEL) from 2016 to 2022 – cohort description, test volumes, predictors of viraemia, and the road ahead
  Purpose The prospective Viral load Cohort North-East Lesotho (VICONEL) aims to support clinical management and generate scientific evidence to inform HIV care. Specifically, VICONEL allows for monitoring of HIV treatment outcomes and health system performance,…
  preprints 2024 置信度 0.74
• New molecular probes reveal callose structural diversity in plant cell wall microdomains
  Abstract Cell walls underpin the mechanics of cell growth, intercellular signalling, and defence against pathogenic organisms. β-(1,3)-glucans (also known as callose) are polysaccharides found in plants, fungi, and some bacterial species. In developing plant o…
  preprints 2026 置信度 0.74