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• Rare bioactive diffusible tau species from Alzheimer brain support both templated misfolding and fibril formation
  In Alzheimer’s disease, both classical neurofibrillary tangles, and diffusible, aqueous soluble (High Molecular Weight, or HMW) species are able to support templated misfolding. How these tau proteoforms relate is uncertain. Using sequential size exclusion and…
  preprints 2025 置信度 0.74
• The Cambridge Centre for Myelin Repair trial Two (CCMR Two): a trial protocol for a phase 2a, randomised, double-blind, placebo-controlled clinical trial of the ability of the combination of metformin and clemastine to promote remyelination in people with relapsing-remitting multiple sclerosis already on disease-modifying therapy
  Abstract Background: In multiple sclerosis (MS) progressive disability occurs following degeneration of demyelinated axons. A tractable approach to delay, prevent, or reverse disability progression is through enhancement of endogenous remyelination. Clinical t…
  preprints 2025 置信度 0.74
• Promoter Hypermethylation and Androgen Receptor Regulation Unveil Dual Oxidase 1 as a Tumor Suppressor in Prostate Adenocarcinoma
  Abstract Promoter hypermethylation of tumor suppressor genes (TSGs) is a hallmark of prostate cancer (PCa) development and holds promise as a diagnostic and prognostic biomarker. Through global methylation analysis of benign prostatic hyperplasia and PCa tissu…
  preprints 2026 置信度 0.74
• Results of the Japan Association of Childhood Leukemia Study (JACLS) NHL-98 protocol for the treatment of B-cell non-Hodgkin lymphoma and mature B-cell acute lymphoblastic leukemia in childhood.
  The Japan Association of Childhood Leukemia Study (JACLS) NHL-98 is a multicenter study designed to evaluate treatment outcomes in Japanese children with B-cell non-Hodgkin lymphoma (B-NHL) and mature B-cell acute lymphoblastic leukemia (B-ALL). The study was …
  pubmed Fujita N, Kobayashi R, Takimoto T, Nakagawa A 等 2011 Feb 置信度 0.82
• Drug delivery systems for differential release in combination therapy.
  Combination therapy with multiple therapeutic agents has wide applicability in medical and surgical treatment, especially in the treatment of cancer. Thus, new drug delivery systems that can differentially release two or more drugs are desired. Utilizing new t…
  pubmed Zhang H, Wang G, Yang H 2011 Feb 置信度 0.82
• The promise and perils of pre-publication review: a multi-agent simulation of biomedical discovery under varying levels of review stringency.
  The Internet has enabled profound changes in the way science is performed, especially in scientific communications. Among the most important of these changes is the possibility of new models for pre-publication review, ranging from the current, relatively stri…
  pubmed Shrager J 2010 May 26 置信度 0.82
• Grounding language in action and perception: from cognitive agents to humanoid robots.
  In this review we concentrate on a grounded approach to the modeling of cognition through the methodologies of cognitive agents and developmental robotics. This work will focus on the modeling of the evolutionary and developmental acquisition of linguistic cap…
  pubmed Cangelosi A 2010 Jun 置信度 0.82
• International collaboration is feasible in trials for rare conditions: the EURAMOS experience.
  The introduction of multi-agent chemotherapy dramatically improved the outcome for patients with osteosarcoma. However, we appear to have reached a plateau in outcome with a long-term event-free survival of 60-70%. Therefore, detection of further improvements …
  pubmed Marina N, Bielack S, Whelan J, Smeland S 等 2009 置信度 0.82
• Combination therapy: opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines.
  The discovery of new molecular targets and the subsequent development of novel anticancer agents are opening new possibilities for drug combination therapy as anticancer treatment. Polymer-drug conjugates are well established for the delivery of a single thera…
  pubmed Greco F, Vicent MJ 2009 Nov 12 置信度 0.82
• Mathematical modeling in metal metabolism: overview and perspectives.
  A review of mathematical modeling in metal metabolism is presented. Both endogenous and exogenous metals are considered. Four classes of methods are considered: Petri nets, multi-agent systems, determinist models based on differential equations and stochastic …
  pubmed Curis E, Nicolis I, Bensaci J, Deschamps P 等 2009 Oct 置信度 0.82
• Conflict detection during plan integration for multi-agent systems.
  This paper describes techniques developed for conflict detection during plan integration. Agents' intensions are represented with intended goal structure (IGS) and the E-PERT diagrams. Conflicts are classified as goal, plan, and belief conflicts. Before integr…
  pubmed Barber KS, Liu TH, Ramaswamy S 2001 置信度 0.82
• yologdev/yoagent-state: v0.5.2
  Follow-up to 0.5.1, from a five-agent review. 0.5.1 shipped two defects of its own — neither a regression from 0.5.0, but both things it claimed were true and weren't. Fixed The "not silent" promise was unreachable. 0.5.1 added replay_with_diagnostics and no i…
  datacite Yuanhao Li 2026 置信度 0.66
• yologdev/yoagent-state: v0.5.2
  Follow-up to 0.5.1, from a five-agent review. 0.5.1 shipped two defects of its own — neither a regression from 0.5.0, but both things it claimed were true and weren't. Fixed The "not silent" promise was unreachable. 0.5.1 added replay_with_diagnostics and no i…
  datacite Yuanhao Li 2026 置信度 0.66
• Memory-Grounded Social Dynamics in Repeated LLM Agent Simulations: Dialogue-Only Transcript Supplement and Behavioral Evaluation Artifacts
  This record contains supplementary research artifacts for the preliminary behavioral evaluation report “Memory-Grounded Social Dynamics in Repeated LLM Agent Simulations”. The uploaded materials support qualitative inspection of repeated multi-agent LLM simula…
  datacite Ubaydullaev, Okhunjon 2026 置信度 0.66 LLM agentsmulti-agent simulationsocial simulationagent memorygenerative agents
• Indistinguishable by Design: Evaluating Pre-Inference Safety Classifiers Across Frontier Language Models
  Frontier language-model services combine request-side gating, model-level safety behavior, generation-time intervention, output controls, routing, conversation state, and actor-level enforcement. An external evaluator normally observes only the composition of …
  datacite Behzadi, David 2026 置信度 0.66 AI safetylarge language modelspre-inference classifierssafety evaluationred teaming
• Indistinguishable by Design: Evaluating Pre-Inference Safety Classifiers Across Frontier Language Models
  Frontier language-model services combine request-side gating, model-level safety behavior, generation-time intervention, output controls, routing, conversation state, and actor-level enforcement. An external evaluator normally observes only the composition of …
  datacite Behzadi, David 2026 置信度 0.66 AI safetylarge language modelspre-inference classifierssafety evaluationred teaming
• Quantum Collapse Geometry
  Quantum Collapse Geometry (QCG) is a collapse-first framework for understanding how structure forms, persists, and is described across physical, cognitive, and complex systems. At its core, QCG is a relational ontology in which structure arises through selecti…
  datacite Garner, Stephen 2026 置信度 0.66 quantum gravityEmergent Spacetimedark matter alternativesquantum collapsefundamental physics
• Quantum Collapse Geometry
  Quantum Collapse Geometry (QCG) is a collapse-first framework for understanding how structure forms, persists, and is described across physical, cognitive, and complex systems. At its core, QCG is a relational ontology in which structure arises through selecti…
  datacite Garner, Stephen 2026 置信度 0.66 quantum gravityEmergent Spacetimedark matter alternativesquantum collapsefundamental physics
• Quantum Collapse Geometry
  Quantum Collapse Geometry (QCG) is a collapse-first framework for understanding how structure forms, persists, and is described across physical, cognitive, and complex systems. At its core, QCG is a relational ontology in which structure arises through selecti…
  datacite Garner, Stephen 2026 置信度 0.66 quantum gravityEmergent Spacetimedark matter alternativesquantum collapsefundamental physics
• Quantum Collapse Geometry
  Quantum Collapse Geometry (QCG) is a collapse-first framework for understanding how structure forms, persists, and is described across physical, cognitive, and complex systems. At its core, QCG is a relational ontology in which structure arises through selecti…
  datacite Garner, Stephen 2026 置信度 0.66 quantum gravityEmergent Spacetimedark matter alternativesquantum collapsefundamental physics
• EnsAgent: a tool-ensemble multiple Agent system for robust annotation in spatial transcriptomics
  Motivation Automated domain annotation in spatially resolved transcriptomics (SRT) remains challenging since it depends on gene expression, morphology, and clinical conventions, which vary across cohorts and platforms. While Large Language Model (LLM)-driven a…
  preprints 2026 置信度 0.74
• Drift: A Biologically-Grounded Cognitive Architecture for Persistent LLM Cognition
  Large language models are stateless by design — each session begins as a blank slate, with memory provided only through context windows or external retrieval. We present Drift , a cognitive architecture that endows stateless LLMs with persistent, biologically-…
  preprints 2026 置信度 0.74
• Underrepresented transition factors from social sciences in energy and emissions modeling
  Abstract Policy-relevant assessments of energy and emissions projections mostly rely on techno-economic modeling. Exploring what drives low-carbon transitions from the perspective of social sciences can help improve the realism and relevance of projections and…
  preprints 2026 置信度 0.74
• Health system and treatment regimen determinants of delayed first-dose antibiotic administration in hospitalized adults in Uganda
  Abstract Background Delayed first-dose antibiotic administration among hospitalized adults partly contributes to poor treatment outcomes. However, the operational drivers of such delays remain poorly characterized in low-resource settings. We sought to delinea…
  preprints 2026 置信度 0.74
• Representation gap for transition factors from social sciences in energy and emissions modeling
  Abstract Policy-relevant assessments of energy and emissions projections in the context of climate change mostly rely on techno-economic modeling. Exploring what drives energy transitions from the perspective of social sciences can help improve the realism and…
  preprints 2026 置信度 0.74
• The Environmental Footprint of Retail Foods at Scale: A Multi-Country Analysis
  Abstract Understanding the environmental impacts of food products is essential for a sustainable food systems transformation, yet such information remains sparse and non-standardized. Here we analyse nearly 475,000 products across 74 countries, quantifying the…
  preprints 2026 置信度 0.74
• Contemporary Treatment Responses of Recurrent Focal Segmental Glomerulosclerosis or Steroid Resistant Nephrotic Syndrome in Children after Kidney Transplantation: Phase 2 of a Multicenter Electronic Health Record Data Analysis
  Abstract Background Recurrence of focal segmental glomerulosclerosis (rFSGS) remains a major complication and a challenge to study treatment efficacy due to lack of granular data in a sufficient sample size. Aggregated data from electronic health records can p…
  preprints 2026 置信度 0.74
• Evidence for asymptomatic TB transmission in rural South Africa
  Abstract Whether asymptomatic TB contributes to M. tuberculosis (Mtb) transmission is critical to global public health strategy. To address this, we evaluated microbiologic, radiographic, molecular and spatial data from a population-based TB study in South Afr…
  preprints 2026 置信度 0.74
• Conceptualizing systems thinking and complexity modelling for circular economy quantification: A systematic review and critical analysis
  Abstract Circular economy (CE) quantification features intrinsic complexity, mandating the application of systems thinking and associated methodologies to navigate multifaceted and dynamic intricacies; posing challenges for science-policy interfacing. Well-est…
  preprints 2025 置信度 0.74
• The role of contact guidance and ECM remodelling in cancer invasion: a computational study
  The extracellular matrix (ECM) is a complex network of fibrous proteins and other macromolecules that provides both structural support and directional cues that regulate cancer cell invasion and tumour progression. Its fibre organisation plays a critical role …
  preprints 2025 置信度 0.74
• Polygenic and familial contributions to antidepressant continuation, switching, discontinuation and augmentation in the All of Us and Pharmlines cohorts
  Predicting antidepressant response remains a major challenge, and it is unclear whether reported polygenic associations reflect drug-specific non-response or a broader propensity for treatment modification. We analysed participants with at least one antidepres…
  preprints 2026 置信度 0.74
• Comparative phenotypic, genomic and transcriptomic characterisation of two <i>Salmonella</i> Typhimurium strains for a first-in-human challenge model
  Background Invasive non-typhoidal Salmonella (iNTS) disease remains a major public health challenge in sub-Saharan Africa. Salmonella Typhimurium is responsible for the majority of cases, with specific lineages being associated with increased risk of bloodstre…
  preprints 2025 置信度 0.74
• Preclinical efficacy of a systemically-administered, second-generation STING agonist that promotes antitumour immunity in combination with radiotherapy
  As potent triggers of innate immunity, STING agonists hold promise as active immunotherapeutic agents for cancer treatment. Second-generation STING agonists, suitable for systemic delivery, are being investigated in preclinical research and have entered clinic…
  preprints 2026 置信度 0.74
• Biodegradable Acoustic Microrobots for Imaging-Guided Rapid Thrombotic Lesion Reperfusion
  Abstract Thrombotic lesions are a leading cause of death and disability worldwide, yet existing thrombolytic therapies suffer from limited efficacy and high risk of hemorrhagic complications. We present a biodegradable microrobotic system composed of hydroxyap…
  preprints 2026 置信度 0.74
• Human brain MRI data of CSF tracer evolution over 72h for data-integrated simulations
  ABSTRACT We present the Gonzo dataset: Brain MRI and derivative data from one healthy male human volunteer (“Gonzo”) before and during the 72 hours after intrathecal injection of the contrast agent gadobutrol into the cerebrospinal fluid (CSF) of the spinal ca…
  preprints 2025 置信度 0.74
• Photoacoustic imaging in mitochondrial disease
  Mitochondrial diseases are a diverse group of inherited neuromuscular disorders leading to progressive disability and early mortality. Mitochondrial myopathy is a common feature of mitochondrial disorders, affecting most patients. Assessment of disease progres…
  preprints 2026 置信度 0.74
• <i>Yersinia pseudotuberculosis</i> employs a multifaceted strategy to survive antimicrobials
  ABSTRACT Microbes have evolved a variety of strategies to survive exposure to naturally occurring and synthetic antimicrobials. These strategies have been investigated extensively in model bacterial organisms, whereas less is known about under explored pathoge…
  preprints 2026 置信度 0.74
• Superantigen-driven polyfunctional CD4+ T follicular regulatory cells impair tonsillar plasmablast function and class-switched antibody production
  Abstract Invasive Staphylococcus aureus infections have high mortality and reinfection rates, in part due to impaired development of enduring antibody-mediated immunity. The generation of pathogen-specific antibodies is typically orchestrated and counter-regul…
  preprints 2026 置信度 0.74
• Combining Network Pharmacology and Experimental Validation to Demonstrate That Salidroside Alleviates Acute Lung Injury by Inhibiting Ferroptosis via the MAPK/GPX4 Pathway
  Abstract Objective This study aimed to combine network pharmacology with in vitro experiments to identify the key targets and potential mechanisms of salidroside (Sal) in the treatment of acute lung injury (ALI). Methods Potential targets related to Sal and AL…
  preprints 2025 置信度 0.74
• Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition
  Mutations in the adenomatous polyposis coli (APC) gene are a defining feature of colorectal cancer (CRC) and impose metabolic and stress-adaptation requirements that may create exploitable vulnerabilities. Prolyl hydroxylase domain (PHD) inhibitors have been e…
  preprints 2026 置信度 0.74
• Metabolomics and metagenomics integration deciphers gut ecosystem changes following prophylactic interventions in commercial broilers
  Abstract Background Intensifying food production systems underscore the need for poultry gut-health strategies aligned with One Health goals. Central to this is a balanced gut microbiota, vital for nutrient absorption, immunity, and disease resilience. Results…
  preprints 2026 置信度 0.74
• Molecular logics in dual sensor regulation of enzyme activity – Phosphorylation OR blue-light activation of cyanobacterial diguanylate cyclases
  Bacterial cells use multiple environmental cues to regulate levels of the second messenger cyclic dimeric GMP. This compound influences key lifestyle decisions such as motility, biofilm formation, or virulence. Although many diguanylate cyclases (DGCs) combine…
  preprints 2026 置信度 0.74
• Inducing TRIB2 Targeted Protein Degradation to Reverse Chemoresistance in Acute Myeloid Leukaemia
  The myeloid oncogene TRIB2 is a key driver of acute myeloid leukaemia (AML) pathogenesis, promoting chemoresistance and blocking differentiation through ubiquitin-mediated degradation of the C/EBPα transcription factor. Despite its stable and sometimes elevate…
  preprints 2025 置信度 0.74
• Differential chromatin response to retinoic acid in neuroblastoma according to type of <i>ATRX</i> mutation
  ABSTRACT Neuroblastoma is a childhood cancer, arising in the developing sympathetic nervous system. Differentiation therapy with 13-cis-retinoic acid (RA) is routinely given to children with high-risk neuroblastoma in the minimal residual disease setting to pr…
  preprints 2025 置信度 0.74
• Herpes simplex virus type 1 DNA is less prevalent in persons with Alzheimer’s disease and genetic factors modify the effect
  INTRODUCTION Herpes simplex virus-1 (HSV-1) has been implicated in Alzheimer disease (AD). METHODS Reads from Alzheimer’s Disease Sequencing Project whole-genome sequencing data collected from brain (2,203 AD; 616 controls) and blood (8,908 AD; 15,768 controls…
  preprints 2026 置信度 0.74
• NRF2 upregulation by CDDO-Me protects AC16 human cardiomyocytes against doxorubicin-induced toxicity
  Doxorubicin (DOX) is an effective anticancer therapeutic but exhibits dose-dependent, potentially life-threatening cardiotoxicity. The specific mechanisms driving this cardiotoxicity are not fully understood but can include the induction of oxidative stress an…
  preprints 2025 置信度 0.74
• Hyphal growth determines spatial organization and coexistence in a pathogenic polymicrobial community within alveoli-like geometries
  ABSTRACT The bodies of macroorganisms host microbes living in multi-species communities. Sequencing approaches have revealed that different organs host different microbiota and tend to be infected by different pathogens, drawing correlations between environmen…
  preprints 2025 置信度 0.74
• Early Radiation Therapy Response Assessment using Multi-scale Photoacoustic Imaging
  There is a critical unmet clinical need to identify biomarkers that predict and detect radiotherapy response in cancer. Using the unique capabilities of multi-scale photoacoustic imaging (PAI) for depicting tumour oxygenation and vasculature in vivo , we ident…
  preprints 2025 置信度 0.74
• Condensate-based shells and scaffolds via interfacial liquid-to-solid transition of disordered peptides
  Living organisms use biomolecular condensates to respond to dynamic environments and create functional materials with complex architectures. Exploring such phase-separated systems beyond the naturally occurring scenarios may offer valuable insights for emergen…
  preprints 2025 置信度 0.74
• A universal protein ladder for standardisation of diverse FRET assays
  ABSTRACT Fluorescence resonance energy transfer (FRET) is the highly distance dependent (3-10 nm) transfer of energy from a donor to an acceptor fluorophore, with transfer efficiency inversely proportional to the distance between the fluorophores. Consequently…
  preprints 2026 置信度 0.74
• Intricate asymbiotic hyphal interactions of <i>Rhizophagus irregularis</i> revealed with single-plane observations in a new microfluidic device
  ABSTRACT Arbuscular mycorrhizal fungi (AMF) are essential symbionts to most land plants. There is great interest in using AMF inoculation treatments to enhance restoration or agricultural efforts. However, little is known about AMF asymbiotic interactions that…
  preprints 2026 置信度 0.74
• Medical management of paraquat induced oral mucositis: A systematic Review
  Paraquat is an extremely corrosive and lethal herbicide. After intentional or unintentional ingestion, paraquat causes extensive mucosal damages extending through the upper gastrointestinal tract which are characterized by pain, inflammation, ulceration, bleed…
  preprints 2023 置信度 0.74
• Modeling COVID-19 Spread using Multi-Agent Simulation with Small-World Network Approach
  Background: The rapid global spread of COVID-19 has seriously impacted people's daily lives and the social economy while also posing a threat to their lives. The analysis of infectious disease transmission is of significant importance for the rational allocati…
  preprints 2023 置信度 0.74
• Redox control of antibiotic biosynthesis
  Streptomyces bacteria make diverse specialised metabolites that form the basis of ∼55% of clinically used antibiotics. Despite this, only 3% of their encoded specialised metabolites have been matched to molecules and understanding how their biosynthesis is con…
  preprints 2025 置信度 0.74
• Epidemic and pandemic preparedness and response in a multi-hazard context: COVID-19 pandemic as a point of reference
  Abstract Background Infectious diseases which manifest in the form of epidemics or pandemics not only cause devastating impacts on public health systems but disrupt the functioning of the entire socio-economic architecture. Further, risks associated with pande…
  preprints 2023 置信度 0.74
• Few-shot learning for highly accelerated 3D time-of-flight MRA reconstruction
  Purpose To develop a deep learning-based reconstruction method for highly accelerated 3D time-of-flight magnetic resonance angiography (TOF-MRA) that achieves high-quality reconstruction with robust generalization using extremely limited acquired raw data, add…
  preprints 2025 置信度 0.74
• Climate change and tuberculosis: an analytical framework
  Summary Climate change is likely to exacerbate a range of determinants which drive tuberculosis, the world’s leading infectious disease killer. However, tuberculosis is often neglected in wider climate health discussions. Commissioned by the World Health Organ…
  preprints 2025 置信度 0.74
• Bridging Evolution and Design: Mapping the Diversity of LOV Photosensors
  Light-sensitive proteins allow organisms to perceive and respond to their environment, and have diversified over billions of years. Among these, Light–Oxygen–Voltage (LOV) domains are widely distributed photosensors that control diverse physiological processes…
  preprints 2025 置信度 0.74
• Toxoplasma gondii-altered host behaviour: elucidating the role of parasite-produced dopamine
  Abstract Certain parasites appear to manipulate their host’s behaviour for their own selective benefit. The mechanisms behind such behavioural alterations in vertebrate hosts remain elusive, despite their profound implications, particularly for those parasites…
  preprints 2025 置信度 0.74
• Electrochemical guided mode resonance biosensor for simultaneous refractive index and electrochemical measurements
  A comprehensive miniaturised biosensing platform needs to detect multiple analytes, which often rely on different transduction mechanisms for their detection and quantification. This necessitates the development of multimodal sensors capable of simultaneous me…
  preprints 2025 置信度 0.74
• A scoping review of definitions and conceptualizations of ecosyndemics in syndemic research
  Background Ecosyndemic research focuses on the role of environmental contextual factors in syndemics. However, there is no consensus on the difference between syndemics and ecosyndemics, as the physical environment is often also included in syndemic studies. T…
  preprints 2025 置信度 0.74
• A unique transcriptomic landscape defines African-specific grade group 1 prostate cancer
  Abstract Background Prostate cancer (PCa) exhibits significant ancestry-related disparity. While men of African ancestry experience higher overall mortality rates, this difference is most pronounced in Sub-Saharan Africa and for grade group 1 (GG1) disease, al…
  preprints 2026 置信度 0.74
• <i>Cryptococcus neoformans</i> responds to presence of mycobacterium by diversifying its morphologies and remodelling its capsular material
  Cryptococcus neoformans and Mycobacterium tuberculosis are opportunistic pathogens that share overlapping geographical distributions and physiological niches within the human body. Both are recognised by the World Health Organization as high-priority pathogens…
  preprints 2025 置信度 0.74
• High-risk clonal groups of Avian Pathogenic <i>Escherichia coli</i> (APEC) demonstrate heterogeneous phenotypic characteristics <i>in vitro</i> and <i>in vivo</i>
  Avian Pathogenic Escherichia coli (APEC), a major bacterial pathogen of poultry, is comprised of a diverse range of high-risk clonal groups. However, phenotypic interactions with the avian host cell and how they may differ between lineages remains poorly under…
  preprints 2025 置信度 0.74
• A human iPSC-based neural spheroid platform for modeling glioblastoma infiltration using high-content imaging
  Abstract Glioblastoma is the most aggressive adult brain tumor, characterized by resistance to therapy and high recurrence due to diffuse infiltration. To mimic glioblastoma migration, we developed a physiologically relevant co-culture model, combining patient…
  preprints 2025 置信度 0.74
• Cytoskeleton Regulates Cytoophidium Dynamics in <i>Drosophila</i> Ovaries
  ABSTRACT Cytoophidia are filamentous structures composed of CTP synthase (CTPS) and were initially discovered in ovarian cells of Drosophila . As a highly conserved membraneless organelle present across all three domains of life, cytoophidia display dynamic be…
  preprints 2025 置信度 0.74
• Humans use a dual policy to improve inferences during epistemic information seeking
  Everyday decisions aim not only to earn rewards but also to learn about the world. Across three studies (total N = 702), we examined how people gather epistemic information stripped of rewarding value, and compared their strategy with reward seeking in otherwi…
  preprints 2025 置信度 0.74
• Why we age: the four process model
  Although ageing can be understood in terms of associated hallmarks and biomarkers, the processes which connect and cause these phenotypes are ill-defined. Here we suggest a unifying model of ageing as four distinct processes which connect the major observation…
  preprints 2026 置信度 0.74
• Blockade of the KRAS-FOSL1 axis elicits DNA damage repair deficiency exploitable with local and systemic genotoxic therapies
  Abstract The clinical approval of direct KRAS inhibitors represents a milestone in precision oncology. Nonetheless, resistance heterogeneity limits durable clinical responses and impedes the nomination of a ‘‘one-size-fits-all’’ strategy for combination therap…
  preprints 2026 置信度 0.74
• Heterogeneity in human brain clearance adds resilience against tauopathy – a computational model informed by glymphatic MRI
  ABSTRACT Neurotoxic protein fragments such as amyloid-beta and tau accumulate in characteristic staging patterns in Alzheimer’s disease (AD). The brain clears such metabolic substances via multiple different systems, including via the glymphatic (extracellular…
  preprints 2025 置信度 0.74
• ProMPt: A modular preclinical platform for functional modelling of prostate cancer heterogeneity and therapeutic vulnerabilities
  ABSTRACT Prostate cancer progression is driven by heterogenous genetic, phenotypic, and microenvironmental programs that remain challenging to model experimentally. Existing systems such as genetically engineered mouse models, xenografts, and patient-derived o…
  preprints 2025 置信度 0.74
• A three-dimensional high throughput assay identifies novel antibacterial molecules with activity against intracellular Shigella
  Abstract The Gram-negative bacterial species Shigella is the second leading cause of diarrhea among children in low and middle-income countries (LMICs) and is a World Health Organization (WHO) priority pathogen. Shigella infections are becoming increasing diff…
  preprints 2025 置信度 0.74
• Plasmodium falciparum Myosin F with a Rab-like tail domain localises to perinuclear membranes and associates with trafficking proteins
  Members of the myosin superfamily are found in all eukaryotes, including Plasmodium falciparum , the parasite that causes malaria. Plasmodium falciparum expresses six myosins, but apart from PfMyoA, these motors remain largely uncharacterised. This includes th…
  preprints 2025 置信度 0.74
• Towards Interactive Explanation-based Nutrition Virtual Coaching Systems
  Abstract The awareness about healthy lifestyles is increasing, opening to personalized intelligent health coaching applications. A demand for more than mere suggestions and mechanistic interactions has driven attention to nutrition virtual coaching systems (NV…
  preprints 2023 置信度 0.74
• Modeling the Spatial Distribution of Different Strains of the COVID-19 Virus Based on the GeoSER(D) Model
  The paper proposed a modification of the GeoSER(D) model previously developed by us by detailing the age structure of the population, personal schedule on weekdays and working days, and individual health characteristics of the agents, this made it possible to …
  preprints 2023 置信度 0.74
• Forty New Genomes Shed Light on Sexual Reproduction and the Origin of Tetraploidy in Microsporidia
  Microsporidia are single-celled, obligately intracellular parasites with growing public health, agricultural, and economic importance. Despite this, Microsporidia remain relatively enigmatic, with many aspects of their biology and evolution unexplored. Key que…
  preprints 2025 置信度 0.74
• A systematic review to identify research gaps in studies modeling vaccination strategies against<i>Neisseria</i>infections
  The genus Neisseria includes two major human pathogens: N. meningitidis causing bacterial meningitis/septicemia and N. gonorrhoeae causing gonorrhoea. Mathematical models have been used to simulate their transmission and control strategies, and the recent obse…
  preprints 2024 置信度 0.74
• Perception-Aware Cooperative Path Planning for Multi-UAV Systems in Urban Wind Fields via Deep Reinforcement Learning.
  The safe deployment of multiple Unmanned Aerial Vehicles (UAVs) in complex urban environments relies heavily on accurate environmental perception and efficient cooperative path planning. However, executing multi-UAV operations in low-altitude airspaces faces s…
  europepmc 2026 置信度 0.80
• Quercetin in COPD: A Multi-Target Approach to Modulate Inflammation, Oxidative Stress, and Epithelial Dysfunction.
  Chronic obstructive pulmonary disease (COPD) is a progressive lung disorder that affects millions of people globally. Although the mechanisms of COPD pathogenesis are not completely known, oxidative stress and lung inflammation caused by chronic exposure to ci…
  europepmc 2026 置信度 0.80
• PriorNav: Prior Knowledge Enhanced Zero-Shot Goal Navigation via Multi-Step Iterative Reasoning.
  Zero-shot goal navigation requires an agent to locate targets in unseen environments based on object categories, reference images, or text descriptions, placing high demands on scene understanding and reasoning. Existing methods mainly rely on online observati…
  europepmc 2026 置信度 0.80
• Research on Multi-Agent Semantic Communication Framework Based on Comparative Learning Joint Optimization.
  With the rapid development of intelligent services, communication objectives are shifting from humans to multi-agent (MA) systems. This transition necessitates new communication paradigms capable of supporting real-time perception, decision-making, and collabo…
  europepmc 2026 置信度 0.80
• Intelligent Support for Radiotherapy: A Review of Clinical Applications for Large Language Models.
  Background : Radiotherapy (RT) is a core modality for cancer treatment, yet it is plagued by inter-observer variability in target delineation, inefficient manual workflows, and challenges in fusing multi-type clinical data. Large language models (LLMs), with t…
  europepmc 2026 置信度 0.80
• An Intelligent Micromachine Perception System for Elevator Fault Diagnosis.
  Elevator fault diagnosis heavily relies on high-precision sensing of microscopic physical states. Although Micro-Electro-Mechanical System (MEMS) sensors can capture such subtle features, they are constrained by high-frequency data streams, environmental noise…
  europepmc 2026 置信度 0.80
• Adaptive multi-objective optimization of microgrid energy management using deep reinforcement learning considering battery degradation and renewable uncertainty.
  Microgrids offer enhanced resilience and efficiency but require sophisticated energy management systems (EMS) to balance conflicting objectives like cost minimization, renewable energy utilization, and component longevity, especially under uncertainty. Traditi…
  europepmc 2026 置信度 0.80
• RSSM-Based Virtual Sensing and Sensorless Closed-Loop Control for a Multi-Temperature-Zone Continuous Crystallizer.
  Precise temperature control is crucial for maintaining product quality and optimizing energy efficiency in multi-zone continuous crystallizers. However, such industrial processes typically exhibit complex nonlinear dynamics and strong coupling effects. More cr…
  europepmc 2026 置信度 0.80
• A Hybrid Deep Learning Architecture for Content Request Prediction in the Internet of Vehicles.
  Low-latency content delivery is essential in the Internet of Vehicles (IoV) to support autonomous driving, cooperative perception, and infotainment services. However, rapidly changing vehicular mobility and demand patterns limit the effectiveness of existing c…
  europepmc 2026 置信度 0.80
• Bank Resolution Trade-Offs Under Coupled Liquidity and Credit Risks: An Agent-Based Network Analysis of Systemic Stability.
  Prolonged downturns in the global economy have simultaneously increased banks' credit risk exposures and intensified the need for effective liquidity management. This study develops a dynamic agent-based financial network comprising banks, depositors, firms, a…
  europepmc 2026 置信度 0.80
• Integrating Large Language Models into Traffic Systems: Integration Levels, Capability Boundaries, and an Information-Theoretic Perspective.
  Large language models (LLMs) are fundamentally transforming intelligent traffic systems by enabling semantic abstraction, probabilistic reasoning, and multimodal information fusion across heterogeneous data. This review examines existing research on LLM integr…
  europepmc 2026 置信度 0.80
• Synthetic Data-Driven Exoskeleton Control via Contralateral Gait Fusion for Variable-Speed Walking.
  Data-driven exoskeletons offer the potential for adaptive augmentation of human mobility. Yet their widespread adoption is hindered by labor-intensive biomechanical data collection and manual tuning. Herein, this study presents a highly efficient synthetic dat…
  europepmc 2026 置信度 0.80
• A Curriculum-Learning-Assisted MAPPO-Based Algorithm for Dynamic Spectrum Access and Anti-Jamming in UAV Swarms.
  The utilization of drone swarms for cooperative missions is becoming increasingly prevalent. However, establishing high-concurrency and highly reliable communication links in complex environments remains a significant challenge. Existing methods based on tradi…
  europepmc 2026 置信度 0.80
• Reinforcement Learning-Driven Autonomous Path Planning for Unmanned Surface Vehicles: Current Status, Challenges, and Future Prospects.
  The continuous advancement of autonomy and intelligence in marine shipping has made the safe and efficient navigation of unmanned surface vehicles in complex waters a major research focus. As a key link of the autonomous decision-making system for unmanned sur…
  europepmc 2026 置信度 0.80
• Hierarchical deep Q-network for anomaly detection and interpretation in multidimensional time-series physical fitness data.
  This paper addresses the critical challenge of achieving both accuracy and interpretability in anomaly detection within complex multidimensional time-series physical fitness data. We design and implement an innovative framework based on a Hierarchical Deep Q-N…
  europepmc 2026 置信度 0.80
• Trajectory Prediction-Enabled Self-Decision-Making for Autonomous Cleaning Robots in Semi-Structured Dynamic Campus Environments.
  Autonomous cleaning robots operating in semi-structured dynamic environments must execute task-oriented motions while safely interacting with surrounding agents. These agents include pedestrians, vehicles, and other robots. In such environments (e.g., interact…
  europepmc 2026 置信度 0.80
• Adaptive traffic signal control using deep reinforcement learning: Toward smarter and safer urban mobility.
  In today's rapidly evolving Intelligent Transportation Systems (ITS), traditional systems for controlling traffic signals are often inadequate in optimizing real-time traffic flow due to their dependency on preset schedules and lack of adaptability to dynamica…
  europepmc 2026 置信度 0.80
• Construction of a "three-stage and four-level" evaluation system for cerebrospinal fluid pathogens based on mNGS: insights from a case of co-detection of Cryptococcus and Epstein-barr virus.
  Background Metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid (CSF) has brought about a revolutionary change in the diagnosis of central nervous system (CNS) infections. Nevertheless, the interpretation of results with multiple detected patho…
  europepmc 2026 置信度 0.80
• Robust service migration for autonomous vehicles leveraging deep learning and cooperative V2V protocols.
  Autonomous vehicles are essentially data centers on wheels. Between self-driving algorithms and high-definition mapping, the demand for instant processing at the network edge is exploding. But here is the snag: keeping those data streams alive while a car is t…
  europepmc 2026 置信度 0.80
• Safe formation scaling and motion planning for heterogeneous UAV-UGV teams in cluttered environments.
  Heterogeneous UAV-UGV formations offer significant potential for autonomous missions; however, achieving stable three-dimensional (3-D) formation control with collision-free navigation in dense obstacle environments remains challenging due to heterogeneous dyn…
  europepmc 2026 置信度 0.80
• From Benign to Lethal: A Case of Aggressive Choriocarcinoma With Systemic Metastases.
  Choriocarcinoma is a rare and aggressive gestational trophoblastic neoplasm that often arises after a molar pregnancy or miscarriage and is characterized by rapid metastatic potential. Diagnosis is typically based on clinical presentation, history of anteceden…
  europepmc 2026 置信度 0.80
• Toward a Structured Imaging Reporting System for Kidney Masses: The Molecular Imaging Perspective on KI-RADS.
  Recently, a structured approach to renal mass characterization known as the Kidney Imaging Reporting and Data System (KI-RADS) was proposed. In that proposal, the authors noted the need for imaging characteristics to be rooted in the biological underpinnings o…
  europepmc 2026 置信度 0.80
• Sparse Communication for Policy Shaping in Multi-Agent Reinforcement Learning.
  Efficient coordination under limited communication is a central challenge in multi-agent reinforcement learning (MARL). Existing approaches often focus on message exchange without explicitly modeling how communication affects policy learning, leading to redund…
  europepmc 2026 置信度 0.80