-
Chapter 2 covers elementary material on the individual stringed instruments: the violin, the viola, the violincello (cello), and the double bass. It should be apparent, even from this brief discussion, that writing for strings is a special technique. What look…
crossref
Kent Kennan, Donald Grantham
2024-04-12T11:20:24Z
置信度 0.73
social and behavioral scienceshabitabilityai governancemartianearth and planetary astrophysics
-
Chapter 17 comments on special devices or considerations involved in scoring for orchestral groups in general. It covers extreme registers, unusual spacing, special dynamic arrangements, the emphasis on colors and textures, divisions of the orchestra into two …
crossref
Kent Kennan, Donald Grantham
2024-04-12T11:20:24Z
置信度 0.71
ai safetyneuromorphic computingphotonicsphysics.geo-phsemiconductor
-
This study explores the integration of AIdriven techniques into cloud orchestration, emphasizing the transformative impact on resource optimization, automation, and scalability. The paper presents realworld case studies across industries, highlighting the bene…
crossref
Rajashekhar Reddy Kethireddy
2024-10-05T12:16:02Z
置信度 0.78
cloud computingtransformative learningcomputer sciencebusinessedge computing
-
Score one of the excerpts below (as specified by the instructor) for strings in six different ways. Use Examples 3.3–3.6 and 3.8–3.11 in Chapter 3 of the text as general models. It is not necessary to rewrite the clef, key signature, meter signature, or tempo …
crossref
Kent Kennan, Donald Grantham
2024-04-11T14:47:55Z
置信度 0.78
multi-agent systemsneuromorphic computingai safetyai governancecomputation
-
Score for woodwinds, horns, and strings, plus percussion—and harp, if desired. Meter changes must be inserted at the actual measures where they occur. This piece is also suitable for an assignment in scoring for strings alone.
crossref
Kent Kennan, Donald Grantham
2024-04-11T14:47:55Z
置信度 0.71
neuromorphic computingecosystemsocial and behavioral sciencescomputational neurosciencecryptography and security
-
These exercises involve two types of transposition. In some cases the actual (concert) sounds are given, and the passage is to be notated in transposed form on the staff above it, with the appropriate key signature. In other cases, the passage is given as it a…
crossref
Kent Kennan, Donald Grantham
2024-04-11T14:47:55Z
置信度 0.78
asteroidsetneuromorphic computingplasma physicsregolith
-
Chapter 7 explores all aspects of the horn, covering: the extreme possible range of the horn and the usual ranges of horns I and III and horns II and IV; transpositions (including the old system of notation in the bass clef); differences between the old natura…
crossref
Kent Kennan, Donald Grantham
2024-04-12T11:20:24Z
置信度 0.78
reliabilityphysics.geo-phplasma physicsgeochemistryneuromorphic computing
-
crossref
Angelo Marchese, Orazio Tomarchio
2024-05-06T16:53:02Z
置信度 0.63
-
Chapter 9 discusses the brass section, which, for purposes of illustration here, is the average one: four horns, two or three trumpets, three trombones, and tuba. The chapter discusses arrangement of instruments on page (order and grouping), principles of bala…
crossref
Kent Kennan, Donald Grantham
2024-04-12T11:20:24Z
置信度 0.76
mathematicsconsciousnessneuromorphic computingnatural language processingperception
-
crossref
Markus Schatten, Tomislav Peharda, Bogdan Okreša Ɖurić
2024-11-19T16:42:42Z
置信度 0.66
-
Centriole number must be restricted to two in cycling cells to avoid pathological cell divisions. Multiciliated cells (MCC), however, need to produce a hundred or more centrioles to nucleate the same number of motile cilia required for fluid flow circulation. …
crossref
2024-05-13T12:25:58Z
置信度 0.82
biologygeologyquant-phastrobiologyai safety
-
Centriole number must be restricted to two in cycling cells to avoid pathological cell divisions. Multiciliated cells (MCC), however, need to produce a hundred or more centrioles to nucleate the same number of motile cilia required for fluid flow circulation. …
crossref
2024-05-13T12:25:58Z
置信度 0.82
biologygeologyquant-phastrobiologyai safety
-
Centriole number must be restricted to two in cycling cells to avoid pathological cell divisions. Multiciliated cells (MCC), however, need to produce a hundred or more centrioles to nucleate the same number of motile cilia required for fluid flow circulation. …
crossref
Jens Lüders
2024-05-13T12:25:58Z
置信度 0.82
biologygeologyquant-phastrobiologyai safety
-
Chapter 18 explores infrequently used instruments, such as the saxophone, the E♭ flute, the bass flute, the oboe d’amore, the basset horn, the heckelphone, the cornet, the sarrusophone, the guitar, the mandolin, the harmonium, and many more.
crossref
Kent Kennan, Donald Grantham
2024-04-12T11:20:24Z
置信度 0.76
neuromorphic computingclimatologymechanical engineeringphysics.geo-phtokamak
-
The latest wireless technology, 5G, promises increased network capacity, reduced costs, and improved energy efficiency. To achieve these benefits, businesses and service providers use advanced technologies such as Virtualized Network Functions (VNFs) and Softw…
crossref
Nipun Agarwal
2024-07-16T13:24:54Z
置信度 0.82
cloud computingnetworking and internet architecturedistributed computingcomputer sciencecs.ni
-
Chapter 21 provides supplementary information on other instrumental groups, groups such as the concert (symphonic) band and wind ensemble, the marching band, the jazz band, and smaller instrumental groups (chamber music).
crossref
Kent Kennan, Donald Grantham
2024-04-12T11:20:24Z
置信度 0.71
earth and planetary astrophysicsmotor imageryadsorptioncs.irmars exploration program
-
Abstract Mitotic onset is a critical transition for eukaryotic cell proliferation. The prevailing view for its control is that cyclin-dependent kinase (CDK) is activated first in the cytoplasm, at the centrosome, which then initiates mitosis 1–3 . Bistability …
crossref
Nitin Kapadia, Paul Nurse
2024-05-02T02:05:19Z
置信度 0.82
biologyai governancecontextphysics.geo-phpopulation
-
crossref
Michael Wiedau
2024-12-13T08:06:21Z
置信度 0.59
-
The strings may well be considered the most important section of the orchestra for a number of reasons, and there is a good deal to be learned about combining the stringed instruments to make up a string orchestra. This chapter covers these things, along with:…
crossref
Kent Kennan, Donald Grantham
2024-04-12T11:20:24Z
置信度 0.78
networking and internet architecturepopulationblockchainsynthetic biologyneuromorphic computing
-
Centriole number must be restricted to two in cycling cells to avoid pathological cell divisions. Multiciliated cells (MCC), however, need to produce a hundred or more centrioles to nucleate the same number of motile cilia required for fluid flow circulation. …
crossref
2024-05-13T12:25:58Z
置信度 0.82
biologygeologyquant-phastrobiologyai safety
-
This chapter covers bowing and special effects. It discusses the various types of bowing and the names commonly used for them (and the indication for each), as well as the special effects obtainable on strings and the names for those. Finally, it touches on th…
crossref
Kent Kennan, Donald Grantham
2024-04-12T11:20:24Z
置信度 0.76
wirelessnetworking and internet architectureinformation theorypetroleum engineeringphysics.geo-ph
-
The following questions pertain to Example 10.13 found on pp. 181–185 of the textbook. Not all of these questions have a definitive answer. Some are intended to promote reflection and discussion.
crossref
Kent Kennan, Donald Grantham
2024-04-11T14:47:55Z
置信度 0.71
large language modelsphysics.geo-phai safetynatural language processingmedical physics
-
Chapter 6 focuses on the instruments involved in the woodwind section in a chamber orchestra and in a full orchestra. Topics covered include the arrangement of the woodwinds on the page (order and grouping); indications for slurring, tonguing, and phrasing; pr…
crossref
Kent Kennan, Donald Grantham
2024-04-12T11:20:24Z
置信度 0.76
philosophytheoretical physicsneuromorphic computingcond-mat.str-elconsciousness
-
The term scoring for full orchestra does not necessarily imply using all the instruments at once; an examination of a large number of scores would reveal that actual tuttis make up a relatively small portion of those scores. Full orchestra means only that all …
crossref
Kent Kennan, Donald Grantham
2024-04-12T11:20:24Z
置信度 0.73
social and behavioral scienceslarge language modelsalgorithmastro-ph.srcs.cl
-
Chapter 20 explores the many aspects of preparing score and parts: what once was done by pencil, or with pen and ink (something of an artform in itself), has now been almost entirely supplanted by music software notation, such as Finale, Sibelius, and Dorico. …
crossref
Kent Kennan, Donald Grantham
2024-04-12T11:20:24Z
置信度 0.71
transformative learningarchitecturedrug discoverynatural language processingai governance
-
Chapter 19 explores the challenges of scoring for the high school orchestra, discussing topics such as the ranges practical for senior and junior high/middle school orchestras, the instrumentation generally used in published arrangements for these orchestras, …
crossref
Kent Kennan, Donald Grantham
2024-04-12T11:20:24Z
置信度 0.76
biomassq-bio.gnmathematics educationq-bio.bmphysics.bio-ph
-
Chapter 11 discusses the problems that can occur in transcribing piano music. In scoring piano music for orchestra, the arranger often comes across certain features that are essentially pianistic rather than orchestral. In such cases a literal transcription of…
crossref
Kent Kennan, Donald Grantham
2024-04-12T11:20:24Z
置信度 0.73
q-bio.mnai governancelarge language modelsemerging technologiestaxonomy
-
Establishing anaesthesia for ensuring both animal welfare and compatibility with protocols required for different areas of scientific research is vital. Zebrafish ( Danio rerio ) are one of the most used animal models in research; however, little is known abou…
preprints
2025
置信度 0.86
medlinemedicinetraditional medicinescience policyintensive care medicine
-
We developed and characterized a three-layer microfluidic Exposure-on-a-Chip (EOC) model to replicate the alveolar microenvironment and simulate breathing motions, offering a physiologically relevant platform for studying inhaled nanomedicines. The EOC chip, f…
preprints
2025
置信度 0.82
materials sciencebiologyroboticscell biologybiological sciences
-
Abstract Background This systematic review sought to examine the application of decision analytic models (DAMs) to evaluate cardiovascular disease (CVD) prevention interventions in sub-Saharan Africa (SSA), a region which has experienced an increasing CVD burd…
preprints
2024
置信度 0.86
medicinemedlinesystematic reviewscience policypsychological intervention
-
Deciding when to enforce or relax non-pharmaceutical interventions (NPIs) based on real-time out-break surveillance data is a central challenge in infectious disease epidemiology. Reporting delays and infection under-ascertainment, which characterise practical…
preprints
2024
置信度 0.86
computer sciencecs.aicomputer and information sciencescs.lgmedicine
-
Abstract Automated blood vessel segmentation is critical for biomedical image analysis, as vessel morphology changes are associated with numerous pathologies. Still, precise segmentation is difficult due to the complexity of vascular structures, anatomical var…
preprints
2024
置信度 0.86
artificial intelligencecomputer sciencecs.lgcs.cvcomputer and information sciences
-
Peripheral nerve stimulation (PNS) offers therapeutic benefits across numerous clinical applications but suffers from limitations in high resolution spatial selectivity, especially in mixed nerves. This study presents a fully polymeric, transverse, multipolar …
preprints
2025
置信度 0.82
materials sciencecomputer scienceneurosciencecond-mat.mtrl-scichemistry
-
Background Parkinson’s disease (PD), multiple sclerosis (MS) and motor neurone disease (MND) are progressive and debilitating diseases that are increasing in prevalence globally. Some primary studies show an increased risk from long-term outdoor air pollution …
preprints
2025
置信度 0.86
medicinescience policybiotechnologysystematic reviewmedline
-
Inventory management is one of the most important components of Alibaba’s business. Traditionally, human buyers make replenishment decisions: although AI algorithms make recommendations, human buyers can choose to ignore these recommendations and make their ow…
preprints
2022
置信度 0.84
computer sciencetaskreinforcement learningcs.lgcs.ro
-
Atopic dermatitis (AD) is a common skin disease with most of the health, social and economic impact driven by those with more severe disease. Determining the molecular pathways that influence severity is therefore crucial, offering opportunity to identify nove…
preprints
2025
置信度 0.86
medicinebiologypsychologybiotechnologyneuroscience
-
Poly(ADP-ribose) polymerase inhibitors (PARPi) have revolutionised the treatment of ovarian high grade serous carcinoma (HGSC), especially those with defective homologous recombination. However, the emergence of resistance poses a critical challenge, as over 5…
preprints
2025
置信度 0.86
medicinematerials sciencenanotechnologybiological sciencesbiotechnology
-
Abstract The outbreak of COVID-19 has once again made people realize the great danger of public health events. To cope with public health events, the central governments in many countries have established emergency management systems and took many measures inc…
preprints
2023
置信度 0.84
sociologycorporate governancemulti-agent systemsrisk analysischina
-
Background Some common infections are associated with poorer age-related health outcomes; however, findings are limited to a small number of pathogens and frequently inconclusive. This study aimed to expand the range of pathogens investigated in relation to fr…
preprints
2025
置信度 0.86
medicinepsychologybiological sciences not elsewhere classifiedsociologymental health
-
Mastering navigation in environments with limited visibility is crucial for survival. Although the hippocam-pus has been associated with goal-oriented navigation, its role in real-world behaviour remains unclear. To investigate this, we combined deep reinforce…
preprints
2023
置信度 0.80
cs.lgcs.aireinforcement learningcomputer and information sciencescomputer science
-
Abstract Inverted perovskite solar cells face performance limitations due to non-radiative recombination at the perovskite surfaces in devices, including functional layers. Advanced characterization and density functional theory reveal that phosphonic acids pa…
preprints
2025
置信度 0.82
materials scienceperovskiteoptoelectronicsquantum dotphysics.app-ph
-
Despite the United States Center for Disease Control (CDC)’s May 2023 expiration of the declared public health emergency pertaining to the COVID-19 pandemic (Silk 2023), approximately 3 years after the first cases of SARS-CoV-2 appeared in the United Sates, th…
preprints
2023
置信度 0.84
social and behavioral sciencesgeographyinternal medicineastro-ph.epmedicine
-
Widespread resistance to all clinically used antibiotics has sparked investigations into alternative sources for novel and effective antimicrobial agents. Metal-based compounds (metalloantibiotics) have emerged as a promising class of potential antibiotics exh…
preprints
2025
置信度 0.86
biologymaterials sciencechemistrypharmacologymedicine
-
Osteoarthritis (OA) affects 600 million individuals globally, pain being a hallmark symptom. Emerging clinical evidence supports the use of mesenchymal stem cells (MSCs) and their extracellular vesicles (MSC-EVs) for pain relief in knee OA. In mice, MSC-EVs am…
preprints
2026
置信度 0.86
psychologyneurosciencepharmacologybiologymedicine
-
The COVID-19 pandemic highlighted the need for predictive deep learning models in healthcare. However, practical prediction task design, fair comparison and model selection for clinical applications remain a challenge. To address this, we introduced and evalua…
preprints
2023
置信度 0.84
artificial intelligencecomputer sciencecs.lgmachine learningdeep learning
-
1 Synthetic cells, constructed through the self-assembly of small molecules, are designed to mimic life-like behaviours by encapsulating functional molecules. For such synthetic cells to accurately replicate cellular reactions, it is critical that the concentr…
preprints
2025
置信度 0.86
materials sciencesynthetic biologynanotechnologychemistrybiology
-
Protein kinases are key regulators of the eukaryotic cell cycle and have consequently emerged as attractive targets for drug development. Their well-defined active sites make them particularly amenable to inhibition by small molecules, underscoring their drugg…
preprints
2025
置信度 0.82
biologybiochemistrydrug discoverycell biologycomputational biology
-
Abstract Background Newer oxazolidinones will be required to advance regimens in pan-TB indications. The addition of host-directed agents may help promote the recovery of lung function during TB treatment and prevent post-TB lung disease. Methods The panTB-HM …
preprints
2025
置信度 0.86
physical medicine and rehabilitationpetroleum engineeringrehabilitationscience policydisease
-
When agent-based models are developed to capture opinion formation in large-scale populations, the opinion update equations often need to embed several complex psychological traits. The resulting models are more realistic, but also challenging to assess analyt…
preprints
2023
置信度 0.80
cs.lgstat.mlphysics.comp-phcomputer sciencestat.ap
-
Abstract Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS ) is an early-onset neurodevelopmental and neurodegenerative disorder characterized by ataxia, spasticity, and peripheral neuropathy. However, several studies have highlighted that some…
preprints
2025
置信度 0.82
medicinepsychologyneurosciencecognitionphysical medicine and rehabilitation
-
Elucidating the spatial and temporal regulation of gene expression during plant organogenesis is crucial for enabling precise crop improvement strategies that incorporate beneficial traits into crops while avoiding adverse effects. Root nodules, specialised or…
preprints
2025
置信度 0.86
biologycomputational biologycomputer sciencecomputer and information sciencesbiological sciences
-
Purpose The prospective Viral load Cohort North-East Lesotho (VICONEL) aims to support clinical management and generate scientific evidence to inform HIV care. Specifically, VICONEL allows for monitoring of HIV treatment outcomes and health system performance,…
preprints
2024
置信度 0.86
medicinemedical physicspsychological interventionhealth caremental health
-
Abstract Cell walls underpin the mechanics of cell growth, intercellular signalling, and defence against pathogenic organisms. β-(1,3)-glucans (also known as callose) are polysaccharides found in plants, fungi, and some bacterial species. In developing plant o…
preprints
2026
置信度 0.77
biologychemistrymaterials sciencebiological sciences not elsewhere classifiedcomputational biology
-
In Alzheimer’s disease, both classical neurofibrillary tangles, and diffusible, aqueous soluble (High Molecular Weight, or HMW) species are able to support templated misfolding. How these tau proteoforms relate is uncertain. Using sequential size exclusion and…
preprints
2025
置信度 0.77
psychologycognitive psychologybiologycognitionbiotechnology
-
Abstract Background: In multiple sclerosis (MS) progressive disability occurs following degeneration of demyelinated axons. A tractable approach to delay, prevent, or reverse disability progression is through enhancement of endogenous remyelination. Clinical t…
preprints
2025
置信度 0.86
medicinephysical medicine and rehabilitationrehabilitationbrain-computer interfaceneuroscience
-
Abstract Promoter hypermethylation of tumor suppressor genes (TSGs) is a hallmark of prostate cancer (PCa) development and holds promise as a diagnostic and prognostic biomarker. Through global methylation analysis of benign prostatic hyperplasia and PCa tissu…
preprints
2026
置信度 0.86
medicinegeneticsbiologybiotechnologycancer
-
The Japan Association of Childhood Leukemia Study (JACLS) NHL-98 is a multicenter study designed to evaluate treatment outcomes in Japanese children with B-cell non-Hodgkin lymphoma (B-NHL) and mature B-cell acute lymphoblastic leukemia (B-ALL). The study was …
pubmed
Fujita N, Kobayashi R, Takimoto T, Nakagawa A 等
2011 Feb
置信度 0.91
medicineinternal medicinephysical medicine and rehabilitationrehabilitationdisease
-
Combination therapy with multiple therapeutic agents has wide applicability in medical and surgical treatment, especially in the treatment of cancer. Thus, new drug delivery systems that can differentially release two or more drugs are desired. Utilizing new t…
pubmed
Zhang H, Wang G, Yang H
2011 Feb
置信度 0.91
nanotechnologydrug discoverytraditional chinese medicinetraditional medicinecond-mat.mtrl-sci
-
The Internet has enabled profound changes in the way science is performed, especially in scientific communications. Among the most important of these changes is the possibility of new models for pre-publication review, ranging from the current, relatively stri…
pubmed
Shrager J
2010 May 26
置信度 0.88
biologyastro-ph.epcs.lgastronomyphysics
-
In this review we concentrate on a grounded approach to the modeling of cognition through the methodologies of cognitive agents and developmental robotics. This work will focus on the modeling of the evolutionary and developmental acquisition of linguistic cap…
pubmed
Cangelosi A
2010 Jun
置信度 0.88
cognitioncognitive scienceembodied cognitionroboticsmulti-agent systems
-
The introduction of multi-agent chemotherapy dramatically improved the outcome for patients with osteosarcoma. However, we appear to have reached a plateau in outcome with a long-term event-free survival of 60-70%. Therefore, detection of further improvements …
pubmed
Marina N, Bielack S, Whelan J, Smeland S 等
2009
置信度 0.88
medicinepsychologyphysical medicine and rehabilitationscience policybrain-computer interface
-
The discovery of new molecular targets and the subsequent development of novel anticancer agents are opening new possibilities for drug combination therapy as anticancer treatment. Polymer-drug conjugates are well established for the delivery of a single thera…
pubmed
Greco F, Vicent MJ
2009 Nov 12
置信度 0.88
drug discoverypharmacologytraditional chinese medicinetraditional medicinecomputational biology
-
A review of mathematical modeling in metal metabolism is presented. Both endogenous and exogenous metals are considered. Four classes of methods are considered: Petri nets, multi-agent systems, determinist models based on differential equations and stochastic …
pubmed
Curis E, Nicolis I, Bensaci J, Deschamps P 等
2009 Oct
置信度 0.88
cs.lgq-bio.mnq-bio.qmcs.mastat.ml
-
This paper describes techniques developed for conflict detection during plan integration. Agents' intensions are represented with intended goal structure (IGS) and the E-PERT diagrams. Conflicts are classified as goal, plan, and belief conflicts. Before integr…
pubmed
Barber KS, Liu TH, Ramaswamy S
2001
置信度 0.88
astrobiologynanotechnologyregolithcontextphysical sciences
-
Follow-up to 0.5.1, from a five-agent review. 0.5.1 shipped two defects of its own — neither a regression from 0.5.0, but both things it claimed were true and weren't. Fixed The "not silent" promise was unreachable. 0.5.1 added replay_with_diagnostics and no i…
datacite
Yuanhao Li
2026
置信度 0.77
ai safetyai governancecomputational neurosciencegeologyneuromorphic computing
-
Follow-up to 0.5.1, from a five-agent review. 0.5.1 shipped two defects of its own — neither a regression from 0.5.0, but both things it claimed were true and weren't. Fixed The "not silent" promise was unreachable. 0.5.1 added replay_with_diagnostics and no i…
datacite
Yuanhao Li
2026
置信度 0.77
ai safetyai governancecomputational neurosciencegeologyneuromorphic computing
-
This record contains supplementary research artifacts for the preliminary behavioral evaluation report “Memory-Grounded Social Dynamics in Repeated LLM Agent Simulations”. The uploaded materials support qualitative inspection of repeated multi-agent LLM simula…
datacite
Ubaydullaev, Okhunjon
2026
置信度 0.79
LLM agentsmulti-agent simulationsocial simulationagent memorygenerative agents
-
Frontier language-model services combine request-side gating, model-level safety behavior, generation-time intervention, output controls, routing, conversation state, and actor-level enforcement. An external evaluator normally observes only the composition of …
datacite
Behzadi, David
2026
置信度 0.79
AI safetylarge language modelspre-inference classifierssafety evaluationred teaming
-
Frontier language-model services combine request-side gating, model-level safety behavior, generation-time intervention, output controls, routing, conversation state, and actor-level enforcement. An external evaluator normally observes only the composition of …
datacite
Behzadi, David
2026
置信度 0.79
AI safetylarge language modelspre-inference classifierssafety evaluationred teaming
-
Quantum Collapse Geometry (QCG) is a collapse-first framework for understanding how structure forms, persists, and is described across physical, cognitive, and complex systems. At its core, QCG is a relational ontology in which structure arises through selecti…
datacite
Garner, Stephen
2026
置信度 0.79
quantum gravityEmergent Spacetimedark matter alternativesquantum collapsefundamental physics
-
Quantum Collapse Geometry (QCG) is a collapse-first framework for understanding how structure forms, persists, and is described across physical, cognitive, and complex systems. At its core, QCG is a relational ontology in which structure arises through selecti…
datacite
Garner, Stephen
2026
置信度 0.79
quantum gravityEmergent Spacetimedark matter alternativesquantum collapsefundamental physics
-
Quantum Collapse Geometry (QCG) is a collapse-first framework for understanding how structure forms, persists, and is described across physical, cognitive, and complex systems. At its core, QCG is a relational ontology in which structure arises through selecti…
datacite
Garner, Stephen
2026
置信度 0.79
quantum gravityEmergent Spacetimedark matter alternativesquantum collapsefundamental physics
-
Quantum Collapse Geometry (QCG) is a collapse-first framework for understanding how structure forms, persists, and is described across physical, cognitive, and complex systems. At its core, QCG is a relational ontology in which structure arises through selecti…
datacite
Garner, Stephen
2026
置信度 0.79
quantum gravityEmergent Spacetimedark matter alternativesquantum collapsefundamental physics
-
Motivation Automated domain annotation in spatially resolved transcriptomics (SRT) remains challenging since it depends on gene expression, morphology, and clinical conventions, which vary across cohorts and platforms. While Large Language Model (LLM)-driven a…
preprints
2026
置信度 0.86
computer sciencecs.aiartificial intelligencecs.lgcomputer and information sciences
-
Large language models are stateless by design — each session begins as a blank slate, with memory provided only through context windows or external retrieval. We present Drift , a cognitive architecture that endows stateless LLMs with persistent, biologically-…
preprints
2026
置信度 0.86
cs.aicomputer scienceartificial intelligencecomputer and information sciencesmulti-agent systems
-
Abstract Policy-relevant assessments of energy and emissions projections mostly rely on techno-economic modeling. Exploring what drives low-carbon transitions from the perspective of social sciences can help improve the realism and relevance of projections and…
preprints
2026
置信度 0.82
businesspsychologycs.aipsychological interventionsociology
-
Abstract Background Delayed first-dose antibiotic administration among hospitalized adults partly contributes to poor treatment outcomes. However, the operational drivers of such delays remain poorly characterized in low-resource settings. We sought to delinea…
preprints
2026
置信度 0.86
medicinepsychologymedlinebiotechnologyscience policy
-
Abstract Policy-relevant assessments of energy and emissions projections in the context of climate change mostly rely on techno-economic modeling. Exploring what drives energy transitions from the perspective of social sciences can help improve the realism and…
preprints
2026
置信度 0.86
climate changenatural resource economicscontextenvironmental economicspsychology
-
Abstract Understanding the environmental impacts of food products is essential for a sustainable food systems transformation, yet such information remains sparse and non-standardized. Here we analyse nearly 475,000 products across 74 countries, quantifying the…
preprints
2026
置信度 0.86
environmental sciencesustainabilitygreenhouse gasbusinessnatural resource economics
-
Abstract Background Recurrence of focal segmental glomerulosclerosis (rFSGS) remains a major complication and a challenge to study treatment efficacy due to lack of granular data in a sufficient sample size. Aggregated data from electronic health records can p…
preprints
2026
置信度 0.86
medicinescience policycancermedlineinternal medicine
-
Abstract Whether asymptomatic TB contributes to M. tuberculosis (Mtb) transmission is critical to global public health strategy. To address this, we evaluated microbiologic, radiographic, molecular and spatial data from a population-based TB study in South Afr…
preprints
2026
置信度 0.82
medicinepsychologyscience policybiotechnologybiological sciences not elsewhere classified
-
Abstract Circular economy (CE) quantification features intrinsic complexity, mandating the application of systems thinking and associated methodologies to navigate multifaceted and dynamic intricacies; posing challenges for science-policy interfacing. Well-est…
preprints
2025
置信度 0.86
computer scienceengineeringbusinessdata scienceartificial intelligence
-
The extracellular matrix (ECM) is a complex network of fibrous proteins and other macromolecules that provides both structural support and directional cues that regulate cancer cell invasion and tumour progression. Its fibre organisation plays a critical role …
preprints
2025
置信度 0.86
biologymaterials sciencecs.aicancerchemistry
-
Predicting antidepressant response remains a major challenge, and it is unclear whether reported polygenic associations reflect drug-specific non-response or a broader propensity for treatment modification. We analysed participants with at least one antidepres…
preprints
2026
置信度 0.77
medicinepsychologyscience policysocial and behavioral sciencescancer
-
Background Invasive non-typhoidal Salmonella (iNTS) disease remains a major public health challenge in sub-Saharan Africa. Salmonella Typhimurium is responsible for the majority of cases, with specific lineages being associated with increased risk of bloodstre…
preprints
2025
置信度 0.86
medicinebiologybiotechnologypharmacologypsychology
-
As potent triggers of innate immunity, STING agonists hold promise as active immunotherapeutic agents for cancer treatment. Second-generation STING agonists, suitable for systemic delivery, are being investigated in preclinical research and have entered clinic…
preprints
2026
置信度 0.86
medicinebiologycancerneurosciencepharmacology
-
Abstract Thrombotic lesions are a leading cause of death and disability worldwide, yet existing thrombolytic therapies suffer from limited efficacy and high risk of hemorrhagic complications. We present a biodegradable microrobotic system composed of hydroxyap…
preprints
2026
置信度 0.86
computer sciencemedicinesoft roboticspharmacologymodular design
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ABSTRACT We present the Gonzo dataset: Brain MRI and derivative data from one healthy male human volunteer (“Gonzo”) before and during the 72 hours after intrathecal injection of the contrast agent gadobutrol into the cerebrospinal fluid (CSF) of the spinal ca…
preprints
2025
置信度 0.86
stat.apeess.ivneuroimagingconvolutional neural networkearth science
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Mitochondrial diseases are a diverse group of inherited neuromuscular disorders leading to progressive disability and early mortality. Mitochondrial myopathy is a common feature of mitochondrial disorders, affecting most patients. Assessment of disease progres…
preprints
2026
置信度 0.77
medicineinternal medicinediseasecancerintensive care medicine
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ABSTRACT Microbes have evolved a variety of strategies to survive exposure to naturally occurring and synthetic antimicrobials. These strategies have been investigated extensively in model bacterial organisms, whereas less is known about under explored pathoge…
preprints
2026
置信度 0.86
biologychemistryenvironmental sciencepsychologyecology
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Abstract Invasive Staphylococcus aureus infections have high mortality and reinfection rates, in part due to impaired development of enduring antibody-mediated immunity. The generation of pathogen-specific antibodies is typically orchestrated and counter-regul…
preprints
2026
置信度 0.86
biologychemistrymedicinecomputational biologycell biology
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Abstract Objective This study aimed to combine network pharmacology with in vitro experiments to identify the key targets and potential mechanisms of salidroside (Sal) in the treatment of acute lung injury (ALI). Methods Potential targets related to Sal and AL…
preprints
2025
置信度 0.77
medicinecancerpharmacologybiologybiological sciences not elsewhere classified
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Mutations in the adenomatous polyposis coli (APC) gene are a defining feature of colorectal cancer (CRC) and impose metabolic and stress-adaptation requirements that may create exploitable vulnerabilities. Prolyl hydroxylase domain (PHD) inhibitors have been e…
preprints
2026
置信度 0.86
biologymedicinepsychologybiotechnologycancer
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Abstract Background Intensifying food production systems underscore the need for poultry gut-health strategies aligned with One Health goals. Central to this is a balanced gut microbiota, vital for nutrient absorption, immunity, and disease resilience. Results…
preprints
2026
置信度 0.86
medicinebiologybiological sciencespsychologysociology
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Bacterial cells use multiple environmental cues to regulate levels of the second messenger cyclic dimeric GMP. This compound influences key lifestyle decisions such as motility, biofilm formation, or virulence. Although many diguanylate cyclases (DGCs) combine…
preprints
2026
置信度 0.86
biologybiotechnologycomputer and information scienceschemistrygenetics
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The myeloid oncogene TRIB2 is a key driver of acute myeloid leukaemia (AML) pathogenesis, promoting chemoresistance and blocking differentiation through ubiquitin-mediated degradation of the C/EBPα transcription factor. Despite its stable and sometimes elevate…
preprints
2025
置信度 0.86
biologypharmacologygeneticsbiochemistrycancer
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ABSTRACT Neuroblastoma is a childhood cancer, arising in the developing sympathetic nervous system. Differentiation therapy with 13-cis-retinoic acid (RA) is routinely given to children with high-risk neuroblastoma in the minimal residual disease setting to pr…
preprints
2025
置信度 0.86
geneticsbiologymedicinepharmacologybiochemistry
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INTRODUCTION Herpes simplex virus-1 (HSV-1) has been implicated in Alzheimer disease (AD). METHODS Reads from Alzheimer’s Disease Sequencing Project whole-genome sequencing data collected from brain (2,203 AD; 616 controls) and blood (8,908 AD; 15,768 controls…
preprints
2026
置信度 0.77
medicinebiologyinternal medicineneurosciencedisease
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Doxorubicin (DOX) is an effective anticancer therapeutic but exhibits dose-dependent, potentially life-threatening cardiotoxicity. The specific mechanisms driving this cardiotoxicity are not fully understood but can include the induction of oxidative stress an…
preprints
2025
置信度 0.86
biologyneurosciencepharmacologymedicinepsychology
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ABSTRACT The bodies of macroorganisms host microbes living in multi-species communities. Sequencing approaches have revealed that different organs host different microbiota and tend to be infected by different pathogens, drawing correlations between environmen…
preprints
2025
置信度 0.86
biologygeologyexoplanetphysicscomputational biology