生物计算

10000 条实体 · 最后更新 2026-08-31T14:44:17.716Z · Bioinform. / Computer science / Plug-in / Biological network / Intersection (aeronautics) / Cluster analysis / Mega- / Emulation / Biology / Software / Virtualization / X-ray

• A Dictionary Learning Approach with Overlap for the Low Dose Computed Tomography Reconstruction and Its Vectorial Application to Differential Phase Tomography
  X-ray based Phase-Contrast Imaging (PCI) techniques have been demonstrated to enhance the visualization of soft tissues in comparison to conventional imaging methods. Nevertheless the delivered dose as reported in the literature of biomedical PCI applications …
  openalex Alessandro Mirone, Emmanuel Brun, Paola Coan 2014-12-22 置信度 0.72 TomographyComputed tomographyDictionary learningPhase (matter)Differential (mechanical device)
• The state and prospects of TB control service in Russia during the COVID-19 pandemic
  The objective: to determine the state and prospects of TB control services including the period during the COVID-19 pandemic. Materials. Data from Federal Statistic Surveillance Forms no. 4, 8, 14, 14-DS, 30, 33, 47, and 61 were analyzed. The number of those d…
  openalex O B Nechaeva 2021-01-18 置信度 0.72 Incidence (geometry)PandemicPopulationMedicineDemography
• Building climate resilience, social sustainability and equity in global fisheries
  Abstract Although the Paris Agreement establishes targets to limit global warming—including carbon market mechanisms—little research has been done on developing operational tools to achieve them. To cover this gap, we use CO2 permit markets towards a market-ba…
  openalex Raúl Prellezo, José María Da Rocha, Maria Lourdes D. Palomares, U. Rashid Sumaila 等 2023-08-07 置信度 0.72 SustainabilityEmissions tradingNatural resource economicsGlobal warmingBusiness
• Simulation of anisotropic growth of low‐grade gliomas using diffusion tensor imaging
  A recent computational model of brain tumor growth, developed to better describe how gliomas invade through the adjacent brain parenchyma, is based on two major elements: cell proliferation and isotropic cell diffusion. On the basis of this model, glioma growt…
  openalex Saâd Jbabdi, Emmanuel Mandonnet, Hugues Duffau, Laurent Capelle 等 2005-08-08 置信度 0.72 Diffusion MRIAnisotropyIsotropyFractional anisotropyAnisotropic diffusion
• The Use of Computed Tomography Densitometry for the Assessment of Emphysema in Clinical Trials: A Position Paper from the Fleischner Society
  Emphysema's significant morbidity and mortality underscore the need for reliable outcome metrics in clinical trials. However, commonly accepted chronic obstructive pulmonary disease outcome measures do not adequately capture emphysema severity or progression. …
  openalex Raúl San Jośe Estépar, R. Graham Barr, Sean B. Fain, Philippe Greniér 等 2025-03-24 置信度 0.72 MedicineDensitometryPosition (finance)Nuclear medicineClinical trial
• Biological use influences the impact of inflammation on risk of major adverse cardiovascular events in rheumatoid arthritis
  OBJECTIVES: Chronic inflammation promotes cardiovascular risk in rheumatoid arthritis (RA). Biological disease-modifying antirheumatic drugs (bDMARDs) improve disease activity and cardiovascular disease outcomes. We explored whether bDMARDs influence the impac…
  openalex George Karpouzas, Sarah R. Ormseth, Piet Leonardus Cornelis Maria van Riel, Miguel Á. González‐Gay 等 2024-07-01 置信度 0.72 MedicineRheumatoid arthritisInflammationAdverse effectIntensive care medicine
• Prenatal and childhood lead exposure is prospectively associated with biological markers of aging in adolescence
  openalex Olivia M. Halabicky, Martha María Téllez‐Rojo, Jaclyn M. Goodrich, Dana C. Dolinoy 等 2024-01-02 置信度 0.72 GeeGeneralized estimating equationMedicineDNA methylationPregnancy
• Clinical biomarker–based biological ageing and the risk of adverse outcomes in patients with chronic kidney disease
  OBJECTIVE: Patients with chronic kidney disease (CKD) show features of premature ageing. We aimed to evaluate the association between biological ageing and adverse outcomes, including end-stage kidney disease (ESKD), cardiovascular diseases (CVD) and all-cause…
  openalex Hao Xiang, Yu Huang, Yuanyuan Zhang, Panpan He 等 2024-10-29 置信度 0.72 MedicineKidney diseaseDiseaseBiomarkerAdverse effect
• Big Data Deep Learning: Challenges and Perspectives
  Deep learning is currently an extremely active research area in machine learning and pattern recognition society. It has gained huge successes in a broad area of applications such as speech recognition, computer vision, and natural language processing. With th…
  openalex Xuewen Chen, Xiaotong Lin 2014-01-01 置信度 0.72 Big dataTransformative learningDeep learningComputer scienceData science
• Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013
  openalex Mohammad H. Forouzanfar, Lily Alexander, H Ross Anderson, Victoria F Bachman 等 2015-09-12 置信度 0.72 Environmental healthRisk assessmentMedicinePopulationRelative risk
• From Generation to Judgment: Opportunities and Challenges of LLM-as-a-judge
  Dawei Li, Bohan Jiang, Liangjie Huang, Alimohammad Beigi, Chengshuai Zhao, Zhen Tan, Amrita Bhattacharjee, Yuxuan Jiang, Canyu Chen, Tianhao Wu, Kai Shu, Lu Cheng, Huan Liu. Proceedings of the 2025 Conference on Empirical Methods in Natural Language Processing…
  openalex Da-Wei Li, Bohan Jiang, Lili Huang, Alimohammad Beigi 等 2025-01-01 置信度 0.72 Natural (archaeology)EpistemologyComputer scienceEmpirical researchNatural language
• Wafer-scale fabrication of memristive passive crossbar circuits for brain-scale neuromorphic computing
  Memristive passive crossbar circuits hold great promise for neuromorphic computing, offering high integration density combined with massively parallel operation. However, scaling up the integration complexity of such circuits remains challenging due to low dev…
  openalex Sanghyeon Choi, Sai Sukruth Bezugam, Tinish Bhattacharya, Dongseok Kwon 等 2025-10-01 置信度 0.72 Neuromorphic engineeringCrossbar switchMemristorComputer scienceScalability
• Integrating Genomics and Proteomics Technologies in Biological Research: Advantages, Challenges, and Prospects
  Introduction: The integration of genomics and proteomics, two cornerstone omics technologies, has transformed our understanding of biological systems, enabling deeper insights into disease mechanisms, biomarker discovery, and the development of personalised me…
  openalex Seyi Samson Enitan, Esther Ngozi Adejumo, Osakue E. Osareniro, S. S. Eke 等 2025-06-29 置信度 0.72 ProteomicsGenomicsData scienceComputational biologyComputer science
• Combining the fourth‐corner and the RLQ methods for assessing trait responses to environmental variation
  Assessing trait responses to environmental gradients requires the simultaneous analysis of the information contained in three tables: L (species distribution across samples), R (environmental characteristics of samples), and Q (species traits). Among the avail…
  openalex Stéphane Dray, Philippe Choler, Sylvain Dolédec, Pedro R. Peres‐Neto 等 2013-09-20 置信度 0.72 TraitOrdinationComplementarity (molecular biology)EcologyMultivariate statistics
• Correspondence of biological condition models of California streams at statewide and regional scales
  We used boosted regression trees (BRT) to model stream biological condition as measured by benthic macroinvertebrate taxonomic completeness, the ratio of observed to expected (O/E) taxa. Models were developed with and without exclusion of rare taxa at a site. …
  openalex Jason T. May, Larry R. Brown, Andrew C. Rehn, Ian R. Waite 等 2014-11-11 置信度 0.72 EcoregionWatershedSTREAMSEnvironmental scienceLand cover
• Unlocking the potential of ecofriendly guardians for biological control of plant diseases, crop protection and production in sustainable agriculture
  openalex Diksha Malik, Satish Kumar, S. S. Sindhu 2025-03-09 置信度 0.72 AgricultureProduction (economics)Crop productionCrop protectionBiotechnology
• Cryo-EM advances in RNA structure determination
  Cryo-electron microscopy (cryo-EM) has emerged as an unprecedented tool to resolve protein structures at atomic resolution. Structural insights of biological samples not accessible by conventional X-ray crystallography and NMR can be explored with cryo-EM beca…
  openalex Haiyun Ma, Xinyu Jia, Kaiming Zhang, Zhaoming Su 2022-02-23 置信度 0.72 Cryo-electron microscopyRNAStructural biologyComputational biologyNanotechnology
• A Research Retrospective on AMD's Exascale Computing Journey
  The pace of advancement of the top-end supercomputers historically followed an exponential curve similar to (and driven in part by) Moore's Law. Shortly after hitting the petaflop mark, the community started looking ahead to the next milestone: Exascale. Howev…
  openalex Gabriel H. Loh, Michael Schulte, Mike Ignatowski, Vignesh Adhinarayanan 等 2023-06-16 置信度 0.72 Exascale computingComputer sciencePaceLook-aheadMilestone
• Expert consensus on regenerative endodontic procedures
  Regenerative endodontic procedures (REPs) is a biologic-based treatment modality for immature permanent teeth diagnosed with pulp necrosis. The ultimate objective of REPs is to regenerate the pulp-dentin complex, extend the tooth longevity and restore the norm…
  openalex Xi Wei, Maobin Yang, Lin Yue, Dingming Huang 等 2022-12-01 置信度 0.72 MedicineDentistryPulp necrosisConfusionEndodontics
• Flexible Synaptic Memristors With Controlled Rigidity in Zirconium‐Oxo Clusters for High‐Precision Neuromorphic Computing
  Abstract Flexible memristors are promising candidates for multifunctional neuromorphic computing applications, overcoming the limitations of conventional computing devices. However, unpredictable switching behavior and poor mechanical stability in conventional…
  openalex Jae–Hyeok Cho, Suk Yeop Chun, Ga Hye Kim, Panithan Sriboriboon 等 2025-01-24 置信度 0.72 Neuromorphic engineeringMemristorMaterials scienceZirconiumRigidity (electromagnetism)
• Rhenium(I) derivatives of aminoquinoline and imidazolopiperidine-based ligands: Synthesis, in vitro and in silico biological evaluation against Plasmodium falciparum
  A small library of aminoquinoline and imidazolopiperidine (IMP)-based ligands, containing the 1,2,3-triazole moiety, and their corresponding tricarbonyl rhenium complexes were synthesised and their inhibitory activities evaluated against the chloroquine-sensit…
  openalex Sara Nasiri Sovari, Taryn M. Golding, Mziyanda Mbaba, Roxanne Mohunlal 等 2022-06-16 置信度 0.72 ChemistryPlasmodium falciparumHemozoinIn silicoStereochemistry
• Malignant peripheral neuroectodermal tumor and its necessary distinction from ewing's Sarcoma. A report from the kiel pediatric tumor registry
  A new classification scheme is proposed for the differential diagnosis of Ewing's sarcoma and malignant peripheral neuroectodermal tumor (MPNT) based on conventional light microscopic and immunohistochemical findings. The presence of Homer-Wright rosettes and/…
  openalex Dietmar Schmidt, C. Herrmann, Herbert Jürgens, Dieter Harms 1991-11-15 置信度 0.72 MedicineEwing's sarcomaSarcomaPathologyNeuroectodermal tumor
• A Novel Task Caching and Migration Strategy in Multi-Access Edge Computing Based on the Genetic Algorithm
  Multi-access edge computing (MEC) brings high-bandwidth and low-latency access to applications distributed at the edge of the network. Data transmission and exchange become faster, and the overhead of the task migration between mobile devices and edge cloud be…
  openalex Lujie Tang, Bing Tang, Linyao Kang, Li Zhang 2019-08-20 置信度 0.72 Computer scienceCacheCloud computingEnhanced Data Rates for GSM EvolutionEnergy consumption
• Benchmarking of participant-level confound regression strategies for the control of motion artifact in studies of functional connectivity
  Since initial reports regarding the impact of motion artifact on measures of functional connectivity, there has been a proliferation of participant-level confound regression methods to limit its impact. However, many of the most commonly used techniques have n…
  openalex Rastko Ćirić, Daniel H. Wolf, Jonathan D. Power, David R. Roalf 等 2017-03-13 置信度 0.72 Artifact (error)RegressionContext (archaeology)Computer scienceArtificial intelligence
• Association between Systemic Immunity-Inflammation Index and Hyperlipidemia: A Population-Based Study from the NHANES (2015–2020)
  The systemic immunity-inflammation index (SII) is a novel inflammatory marker, and aberrant blood lipid levels are linked to inflammation. This study aimed to look at the probable link between SII and hyperlipidemia. The current cross-sectional investigation w…
  openalex Nayili Mahemuti, Xiyue Jing, Naijian Zhang, Chuanlang Liu 等 2023-02-26 置信度 0.72 HyperlipidemiaMedicineNational Health and Nutrition Examination SurveyInternal medicineBody mass index
• Quantum-centric high performance computing for quantum chemistry
  High performance computing (HPC) is renowned for its capacity to tackle complex problems. Meanwhile, quantum computing (QC) provides a potential way to accurately and efficiently solve quantum chemistry problems. The emerging field of quantum-centric high perf…
  openalex Jie Liu, Huan Ma, Honghui Shang, Zhenyu Li 等 2024-01-01 置信度 0.72 Quantum computerQuantum chemistryComputer scienceSupercomputerQuantum
• Organic aerosol and global climate modelling: a review
  Abstract. The present paper reviews existing knowledge with regard to Organic Aerosol (OA) of importance for global climate modelling and defines critical gaps needed to reduce the involved uncertainties. All pieces required for the representation of OA in a g…
  openalex Maria Kanakidou, John H. Seinfeld, Spyros Ν. Pandis, Ian Barnes 等 2005-03-30 置信度 0.72 AerosolEnvironmental scienceGlobal climateClimate modelClimate change
• A validation study of the WHO method for cancer pain relief
  The method for cancer pain relief proposed by the World Health Organization (WHO) consists of guidelines for a three-step treatment, from non-opioids to weak and then strong opioids, according to need. Adjuvant drugs can be added to each step. This report pres…
  openalex Vittorio Ventafridda, Marcello Tamburini, Augusto Caraceni, Franco De Conno 等 1987-02-15 置信度 0.72 MedicineCancer painAnalgesicPain reliefCancer
• SEOM–SOGUG clinical guideline for urothelial cancer (2025)
  This clinical guideline provides evidence-based recommendations for the diagnosis, staging, and management of bladder cancer across all disease stages. In these guidelines (updated in 2025), we summarize current evidence and available therapies for the medical…
  openalex Javier Puente, Alejo Rodríguez‐Vida, Elena Sevillano, Sergio Vázquez‐Estévez 等 2025-09-17 置信度 0.72 MedicineGuidelineUrothelial cancerBladder cancerDisease
• AI-driven multi-omics integration in precision oncology: bridging the data deluge to clinical decisions
  Cancer's staggering molecular heterogeneity demands innovative approaches beyond traditional single-omics methods. The integration of multi-omics data, spanning genomics, transcriptomics, proteomics, metabolomics and radiomics, can improve diagnostic and progn…
  openalex Chou‐Yi Hsu, Shavan Askar, Samer Saleem Alshkarchy, Priya Priyadarshini Nayak 等 2025-11-21 置信度 0.72 Data integrationBridging (networking)ProteogenomicsComputer sciencePrecision medicine
• Multiscale elasticity mapping of biological samples in 3D at optical resolution
  openalex Kathryn Regan, Robert LeBourdais, Rohin Banerji, Sue Zhang 等 2023-12-29 置信度 0.72 Materials scienceElasticity (physics)Image resolutionResolution (logic)Composite material
• Ionic Device: From Neuromorphic Computing to Interfacing with the Brain
  In living organisms, the modulation of ion conductivity in ion channels of neuron cells enables intelligent behaviors, such as generating, transmitting, and storing neural signals. Drawing inspiration from these natural processes, researchers have fabricated i…
  openalex Zijia Huang, Tingting Mei, Xinyi Zhu, Kai Xiao 2025-02-06 置信度 0.72 Neuromorphic engineeringInterfacingComputer scienceArtificial neural networkIonic liquid
• Cross-validation is safe to use
  openalex Ross D. King, Oghenejokpeme I. Orhobor, Charles Taylor 2021-04-20 置信度 0.72 Environmental science
• AI-driven multi-omics integration for multi-scale predictive modeling of genotype-environment-phenotype relationships
  Despite the wealth of single-cell multi-omics data, it remains challenging to predict the consequences of novel genetic and chemical perturbations in the human body. It requires knowledge of molecular interactions at all biological levels, encompassing disease…
  openalex You Wu, Lei Xie 2025-01-01 置信度 0.72 OmicsPhenotypeScale (ratio)Computational biologyGenotype
• Coarse-grained models for ionic liquids and applications to biological and electrochemical systems
  This review article highlights recent advances in the development of coarse-grained models for ionic liquids and their applications, as well as the challenges and future directions in this field.
  openalex Ge Yang, Qiang Zhu, Xueping Wang, Jing Ma 2025-01-01 置信度 0.72 Ionic liquidElectrochemistryIonic bondingComputer scienceNanotechnology
• Affective computing in the context of music therapy: a systematic review
  Music therapy is an effective tool to slow down the progress of dementia since interaction with music may evoke emotions that stimulates brain areas responsible for memory. This therapy is most successful when therapists provide adequate and personalized stimu…
  openalex Maí­ra Araújo de Santana, Clarisse Lins de Lima, Arianne Sarmento Torcate, Flávio Secco Fonseca 等 2021-11-28 置信度 0.72 Computer scienceContext (archaeology)MetadataPersonalizationField (mathematics)
• Direct Fan‐Beam Reconstruction Algorithm via Filtered Backprojection for Differential Phase‐Contrast Computed Tomography
  Recently, a novel data acquisition method has been proposed and experimentally implemented for differential phase‐contrast computed tomography (DPC‐CT), in which a conventional X‐ray tube and a Talbot‐Lau‐type interferometer were utilized in data acquisition. …
  openalex Zhihua Qi, Guang‐Hong Chen 2008-01-01 置信度 0.72 AlgorithmComputer scienceReconstruction algorithmIterative reconstructionArtificial intelligence
• Variance partitioning of stream diatom, fish, and invertebrate indicators of biological condition
  Stream indicators used to make assessments of biological condition are influenced by many possible sources of variability. To examine this issue, we used multiple-year and multiple-reach diatom, fish, and invertebrate data collected from 20 least-disturbed and…
  openalex Robert E. Zuellig, Daren M. Carlisle, Michael R. Meador, Marina Potapova 2012-01-24 置信度 0.72 Variance (accounting)Sampling (signal processing)ResidualInvertebrateStatistics
• OMICmAge quantifies biological age by integrating multi-omics with electronic medical records
  Biological aging reflects complex cellular and biochemical processes that can be measured across multiple omic layers. Using routine clinical laboratory data from ~31,000 participants in the Mass General Brigham Biobank, we developed EMRAge, a biomarker of mor…
  openalex Qingwen Chen, Varun B. Dwaraka, Natàlia Carreras-Gallo, Judith Armstrong 等 2026-02-25 置信度 0.72 BiobankBiological ageBiomarkerDNA methylationEpigenetics
• On the conservative behavior of biomass water productivity
  The ever-increasing demand and competition for the finite water resource worldwide call for more efficient use of water in all sectors, including firstly agricultural food production. One important consideration is the existence of a limit to the amount of bio…
  openalex Pasquale Steduto, Theodore C. Hsiao, Elías Fereres 2007-02-02 置信度 0.72 Environmental scienceBiomass (ecology)ProductivityAgricultureNormalization (sociology)
• Wastewater treatment plant performance analysis using artificial intelligence – an ensemble approach
  Abstract In the present study, three different artificial intelligence based non-linear models, i.e. feed forward neural network (FFNN), adaptive neuro fuzzy inference system (ANFIS), support vector machine (SVM) approaches and a classical multi-linear regress…
  openalex Vahid Nourani, Gözen Elkiran, Sani I. Abba 2018-11-20 置信度 0.72 Ensemble forecastingSupport vector machineEnsemble learningArtificial neural networkAdaptive neuro fuzzy inference system
• A horizon scan of biological conservation issues for 2026
  We present outcomes from our 17th horizon scan of issues potentially impacting global biodiversity conservation in the next decade. Issues are novel, or represent a significant step-change in impact, and are currently not well-known or understood within the co…
  openalex William J. Sutherland, Stuart H. M. Butchart, Stewart J. Clarke, Nigel Doar 等 2025-12-03 置信度 0.72 BiodiversityHorizonBiodiversity conservationEnvironmental resource managementTime horizon
• Machine learning in biological research: key algorithms, applications, and future directions
  Machine learning is a robust framework to analyze questions using complex data in a variety of fields. We present definitions and recent applications of four key machine learning methods and discuss their advantages and challenges in biological research. Throu…
  openalex Md Nafis Ul Alam, Kiran Basava, Ani Chitransh, H. M. Abdul Fattah 等 2025-10-29 置信度 0.72 Machine learningArtificial intelligenceKey (lock)Intersection (aeronautics)Variety (cybernetics)
• Self-regulated biological transportation structures with general entropy dissipation: 2D case and leaf-shaped domain
  In recent years, the study of biological transportation networks has attracted significant interest, focusing on their self-regulating, demand-driven nature. This paper examines a mathematical model for these networks, featuring nonlinear elliptic equations fo…
  openalex Clarissa Astuto, Peter Markowich, Simone Portaro, Giovanni Russo 2026-01-31 置信度 0.72 Nonlinear systemMathematicsSemigroupEntropy (arrow of time)Finite element method
• Enabling end-to-end secure federated learning in biomedical research on heterogeneous computing environments with APPFLx
  . Furthermore, it is completely agnostic to the underlying computational infrastructure of participating clients, allowing an instantaneous deployment of this framework into existing computing infrastructures. Experimentally, the utility of APPFLx is demonstra…
  openalex Trung-Hieu Hoang, Jordan Fuhrman, Marcus D. R. Klarqvist, Miao Li 等 2024-12-13 置信度 0.72 End-to-end principleComputer scienceEnd userDistributed computingData science
• Triiron Complex with N-Ferrocenyl Aminocarbyne Ligand Bridging a Diiron Core: DFT, Electrochemical, and Biological Insights
  , showed a substantial ability to induce intracellular ROS production, and outperformed cisplatin in a three-dimensional SCLC cell model.
  openalex Chiara Saviozzi, Lorenzo Biancalana, Tiziana Funaioli, Marco Bortoluzzi 等 2024-01-03 置信度 0.72 ChemistryTrifluoromethanesulfonateElectrochemistrySubstituentRedox
• A Conceptual Approach to Time Savings and Cost Competitiveness Assessments for Drone Transport of Biologic Samples with Unmanned Aerial Systems (Drones)
  Unmanned aerial vehicles (UAVs, drones) are expected to save transport time and improve service reliability for transport of biologic samples, but few studies have evaluated the potential time savings of such services. The total transport time defined as time …
  openalex Karl-Arne Johannessen 2022-02-27 置信度 0.72 DroneTRIPS architectureProxy (statistics)Scheduling (production processes)Environmental science
• Perspective on the applications of terahertz imaging in skin cancer diagnosis
  Applications of terahertz (THz) imaging technologies have advanced significantly in the disciplines of biology, medical diagnostics, and non- destructive testing in the past several decades. Significant progress has been made in THz biomedical imaging, allowin…
  openalex Hamza Abu Owida, Jamal Al-Nabulsi, Muhammad Al-Ayyad, Nidal Turab 等 2024-11-18 置信度 0.72 Terahertz radiationMedical imagingTerahertz gapTerahertz spectroscopy and technologyFar-infrared laser
• Size, shape, and form: concepts of allometry in geometric morphometrics
  Allometry refers to the size-related changes of morphological traits and remains an essential concept for the study of evolution and development. This review is the first systematic comparison of allometric methods in the context of geometric morphometrics tha…
  openalex Christian Peter Klingenberg 2016-04-01 置信度 0.72 AllometryMorphometricsProcrustes analysisShape analysis (program analysis)Mathematics
• Enfortumab Vedotin and Pembrolizumab in Untreated Advanced Urothelial Cancer
  BACKGROUND: No treatment has surpassed platinum-based chemotherapy in improving overall survival in patients with previously untreated locally advanced or metastatic urothelial carcinoma. METHODS: We conducted a phase 3, global, open-label, randomized trial to…
  openalex Thomas Powles, Begoña P. Valderrama, Shilpa Gupta, Jens Bedke 等 2024-03-06 置信度 0.72 PembrolizumabMedicineCarboplatinInternal medicineHazard ratio
• Unsupervised Multi-Omics Data Integration Methods: A Comprehensive Review
  Through the developments of Omics technologies and dissemination of large-scale datasets, such as those from The Cancer Genome Atlas, Alzheimer’s Disease Neuroimaging Initiative, and Genotype-Tissue Expression, it is becoming increasingly possible to study com…
  openalex Nasim Vahabi, George Michailidis 2022-03-22 置信度 0.72 OmicsData integrationComputer scienceData scienceLeverage (statistics)
• Stable recurrent dynamics in heterogeneous neuromorphic computing systems using excitatory and inhibitory plasticity
  Many neural computations emerge from self-sustained patterns of activity in recurrent neural circuits, which rely on balanced excitation and inhibition. Neuromorphic electronic circuits represent a promising approach for implementing the brain's computational …
  openalex Maryada Maryada, Saray Soldado-Magraner, Martino Sorbaro, Rodrigo Laje 等 2025-07-01 置信度 0.72 Neuromorphic engineeringExcitatory postsynaptic potentialInhibitory postsynaptic potentialDynamics (music)Computer science
• AN ATTEMPT AT A NATURAL SCIENCE EXPLANATION OF THE UFO/UAP PHENOMENON IN THE CONTEXT OF THE ACTA UNIVERSI 2025 HYPOTHESIS
  Abstract The paper presents a study of the UFO/UAP phenomenon in the context of the new Acta Universi hypothesis about the nature of dark energy. The research is based on the analysis of modern cosmological data and theoretical models. The relevance of the wor…
  openalex Dmitry Yashchenko 2025-11-20 置信度 0.72 PhenomenonEpistemologyNoveltyContext (archaeology)Relevance (law)
• Model-Based and Data-Driven Strategies in Medical Image Computing
  Model-based approaches for image reconstruction, analysis, and interpretation have made significant progress over the past decades. Many of these approaches are based on either mathematical, physical, or biological models. A challenge for these approaches is t…
  openalex Daniel Rueckert, Julia A. Schnabel 2019-10-14 置信度 0.72 InterpretabilityComputer scienceArtificial intelligenceRobustness (evolution)Deep learning
• 2025: research in review
  openalex 2025-12-01 置信度 0.72 Convergence (economics)Computer scienceData scienceGeneComputational biology
• Global artificial light masks biologically important light cycles of animals
  We document the importance of low‐light conditions in 136 animal species and then translate the new world atlas of skyglow, which reports artificial night sky brightness, into estimates of anthropogenic illuminance (that is, artificial light reaching Earth's s…
  openalex Brett Seymoure, Rachel T. Buxton, Jeremy White, Carlos R Linares 等 2025-01-20 置信度 0.72 Artificial lightEnvironmental scienceOpticsPhysicsIlluminance
• Efficacy of synthetic and biological DMARDs: a systematic literature review informing the 2025 update of the EULAR recommendations for the management of rheumatoid arthritis
  OBJECTIVES: This systematic literature review (SLR) updated evidence on the efficacy of disease-modifying antirheumatic drugs (DMARDs) and glucocorticoids (GCs) to inform the 2025 update of the European Alliance of Associations for Rheumatology (EULAR) managem…
  openalex Victoria Konzett, Faidra Laskou, Josef S. Smolen, Christopher J. Edwards 等 2026-04-16 置信度 0.72 MedicineSystematic reviewRheumatoid arthritisIntensive care medicineAlternative medicine
• Reviewing primary Sjögren's syndrome: beyond the dryness - From pathophysiology to diagnosis and treatment
  Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease, characterized by lymphocytic infiltration of the secretory glands. This process leads to sicca syndrome, which is the combination of dryness of the eyes, oral cavity, pharynx, larynx and/or vag…
  openalex Tim Both, Virgil A. S. H. Dalm, P. Martin van Hagen, Paul Van Daele 2017-01-01 置信度 0.72 MedicineB-cell activating factorRituximabPathogenesisAutoantibody
• Synthesis, characterization, computational and biological evaluation of pyrazole hydrazones as promising anti-inflammatory agents
  In this study, two pyrazole-based hydrazone derivatives, 5-methyl-1-phenyl-4-(1-(2-phenylhydrazineylidene)ethyl)-1 H -pyrazole ( PMPH ) and 1-(4-fluorophenyl)-5-methyl-4-(1-(2-phenylhydrazineylidene)ethyl)-1 H -pyrazole ( 4 F - PMPH ), were synthesized and the…
  openalex Hemant S. Deshmukh, Vishnu A. Adole, A. Alfind Paul Frit, Suraj N. Mali 等 2025-11-23 置信度 0.72 ChemistryADMEMolecular orbitalMulliken population analysisComputational chemistry
• Ten new insights in climate science 2025
  Abstract Non-Technical Summary This review highlights 10 recent advances in climate change research with high policy relevance, spanning diverse topics: (1) the global temperature jump of 2023–2024; (2) sea surface warming and marine heatwaves; (3) land carbon…
  openalex Daniel Ospina, Paula Mirazo, Richard P. Allan, Smriti Basnett 等 2026-01-01 置信度 0.72 Climate changeEcological forecastingGreenhouse gasNatural resource economicsGlobal warming
• Pediatric computed tomography scan and subsequent risk of malignancy: a nationwide population-based cohort study in Korea using National Cancer Institute dosimetry system for computed tomography (NCICT)
  BACKGROUND: Computed tomography (CT) has advanced medical diagnostics by offering detailed anatomical imaging, but its use in children raises concerns due to higher radiation doses and increased vulnerability. This study enhances prior research by using organ-…
  openalex Sangsoo Han, Jaewan Soh, Sangun Nah, Kyungdo Han 等 2025-07-01 置信度 0.72 MedicineCohortCancerPopulationHazard ratio
• Boundary Element Method Solution of a Fractional Bioheat Equation for Memory-Driven Heat Transfer in Biological Tissues
  This work develops a Boundary Element Method (BEM) formulation for simulating bioheat transfer in perfused biological tissues using the Atangana–Baleanu fractional derivative in the Caputo sense (ABC). The ABC operator incorporates a nonsingular Mittag–Leffler…
  openalex Mohamed Abdelsabour Fahmy, Ahmad Almutlg 2025-08-28 置信度 0.72 Bioheat transferDiscretizationFractional calculusBoundary element methodThermal conduction
• Green Computing Technologies and Computing Industry in 2021
  The book presents innovations in green computing technologies. A large number of computing devices and cellular phones being produced and discarded is hurtling us toward a global environmental disaster. In the last fifty years, the earth has experienced rapid …
  openalex Albert Sabban 2020-12-11 置信度 0.72 SeawaterEmerging technologiesGlobal environmental analysisGreen computingInternet of Things
• Energy transmission through radiative ternary nanofluid flow with exponential heat source/sink across an inclined permeable cylinder/plate: numerical computing
  Abstract The steady two-dimension (2D) ternary nanofluid (TNF) flow across an inclined permeable cylinder/plate is analyzed in the present study. The TNF flow has been examined under the consequences of heat source/sink, permeable medium and mixed convection. …
  openalex Muhammad Bilal, M. Waqas, Jana Shafi, Mati ur Rahman 等 2023-12-14 置信度 0.72 NanofluidMaterials scienceMechanicsPorous mediumTernary operation
• Climate Impacts on Lake Food‐Webs Are Mediated by Biological Invasions
  Climate change and biological invasions are among the most important drivers of biodiversity and ecosystem change. Despite major advances in understanding their ecological impacts, these drivers are often considered individually, overlooking their possible com…
  openalex Camille Leclerc, Victor Frossard, Najwa Sharaf, Simon Bazin 等 2025-03-01 置信度 0.72 Climate changeEcologyEnvironmental scienceGeographyBiology
• Excitable dynamics driven by mechanical feedback in biological tissues
  Pulsatory activity patterns, driven by mechanochemical feedback, are prevalent in many biological systems. However, the role of cellular mechanics and geometry in the propagation of pulsatory signals remains poorly understood. Here we present a theoretical fra…
  openalex Fernanda Pérez-Verdugo, Samuel Banks, Shiladitya Banerjee 2024-05-24 置信度 0.72 Pulsatile flowMulticellular organismDynamics (music)Pulse (music)Wave speed
• PITRE : software for phase-sensitive X-ray image processing and tomography reconstruction
  Synchrotron-radiation computed tomography has been applied in many research fields. Here, PITRE (Phase-sensitive X-ray Image processing and Tomography REconstruction) and PITRE_BM (PITRE Batch Manager) are presented. PITRE supports phase retrieval for propagat…
  openalex Rong-Chang Chen, Diego Dreossi, Lucia Mancini, R.H. Menk 等 2012-08-01 置信度 0.72 TomographySoftwareComputer scienceGraphical user interfaceSynchrotron radiation
• Large-Area Soft e-Skin: The Challenges Beyond Sensor Designs
  Sensory feedback from touch is critical for many tasks carried out by robots and humans, such as grasping objects or identifying materials. Electronic skin (e-skin) is a crucial technology for these purposes. Artificial tactile skin that can play the roles of …
  openalex Ravinder Dahiya, Nivasan Yogeswaran, Fengyuan Liu, Libu Manjakkal 等 2019-10-01 置信度 0.72 Neuromorphic engineeringSoft roboticsRoboticsElectronicsComputer science
• Origin of yield stress and mechanical plasticity in model biological tissues
  During development and under normal physiological conditions, biological tissues are continuously subjected to substantial mechanical stresses. In response to large deformations, cells in a tissue must undergo multicellular rearrangements to maintain integrity…
  openalex Anh Q Nguyen, Junxiang Huang, Dapeng Bi 2025-04-05 置信度 0.72 PlasticityYield (engineering)Stress (linguistics)BiologyMaterials science
• Frontiers in artificial intelligence‐directed light‐sheet microscopy for uncovering biological phenomena and multiorgan imaging
  Light-sheet fluorescence microscopy (LSFM) introduces fast scanning of biological phenomena with deep photon penetration and minimal phototoxicity. This advancement represents a significant shift in 3-D imaging of large-scale biological tissues and 4-D (space …
  openalex Enbo Zhu, Yan‐Ruide Li, Samuel Margolis, Jing Wang 等 2024-09-03 置信度 0.72 Light sheet fluorescence microscopyMicroscopyArtificial intelligenceComputer scienceMedicine
• Analysing biological colour patterns from digital images: An introduction to the current toolbox
  Understanding the numerous roles that colouration serves in the natural world has remained a central focus in many evolutionary and ecological studies. However, to accurately characterise and then compare colours or patterns among individuals or species has be…
  openalex Christopher R. Hemingson, Peter F. Cowman, David R. Bellwood 2024-03-01 置信度 0.72 ToolboxCurrent (fluid)Computer scienceComputer graphics (images)Artificial intelligence
• Wireless Communications and Applications Above 100 GHz: Opportunities and Challenges for 6G and Beyond
  Frequencies from 100 GHz to 3 THz are promising bands for the next generation of wireless communication systems because of the wide swaths of unused and unexplored spectrum. These frequencies also offer the potential for revolutionary applications that will be…
  openalex Theodore S. Rappaport, Yunchou Xing, Ojas Kanhere, Shihao Ju 等 2019-01-01 置信度 0.72 Computer scienceWirelessElectronic engineeringWireless networkTelecommunications
• Smart Wound Dressings and the Biological Parameters They Monitor: A Scoping Review
  Chronic wounds represent a major global health and economic burden. Smart wound dressings integrate biosensing and stimuli-responsive materials to monitor and modulate biological parameters within the wound microenvironment. This scoping review maps the biolog…
  openalex Sebastian Probst, Alessio Stefanelli, Sophie Groux, Natacha Bossi 等 2026-04-01 置信度 0.72 MedicineIntensive care medicineClinical trialPreclinical testingHuman studies
• The relative importance of physicochemical factors to stream biological condition in urbanizing basins: evidence from multimodel inference
  Many physicochemical factors potentially impair stream ecosystems in urbanizing basins, but few studies have evaluated their relative importance simultaneously, especially in different environmental settings. We used data collected in 25 to 30 streams along a …
  openalex Wade L. Bryant, Daren M. Carlisle 2012-01-24 置信度 0.72 Akaike information criterionOrdinationEcologyMetric (unit)Ecosystem
• Safety of Biologic and Small Molecule Therapy for Inflammatory Bowel Disease Among Solid Organ Transplant Recipients: Systematic Review and Meta-Analysis
  BACKGROUND: Patients undergoing organ transplantation are often on immunosuppressing medications to prevent rejection of the transplant. The data on use of concomitant immunosuppression for inflammatory bowel disease (IBD) and organ transplant management are l…
  openalex Vikas Taneja, Rajsavi Anand, Mohammed El-Dallal, Jeffrey Dong 等 2023-06-10 置信度 0.72 MedicineVedolizumabInfliximabAdalimumabInternal medicine
• MACE-OFF: Short-Range Transferable Machine Learning Force Fields for Organic Molecules
  Classical empirical force fields have dominated biomolecular simulations for over 50 years. Although widely used in drug discovery, crystal structure prediction, and biomolecular dynamics, they generally lack the accuracy and transferability required for first…
  openalex Dávid Péter Kovács, J. Harry Moore, Nicholas J. Browning, Ilyes Batatia 等 2025-05-19 置信度 0.72 ChemistryMaceMoleculeRange (aeronautics)Organic molecules
• Interaction Between Climate Change Scenarios and Biological Invasion Reveals Complex Cascading Effects in Freshwater Ecosystems
  Climate change often facilitates biological invasions, leading to potential interactive impacts of these global drivers on freshwater ecosystems. Although climatic mitigation efforts may reduce the magnitude of these interactive impacts, we are still missing e…
  openalex Tauany Rodrigues, Pavel Kratina, Rayanne Barros Setubal, Joseph L. S. Ferro 等 2024-10-01 置信度 0.72 MacrophyteTrophic levelClimate changeEnvironmental scienceEcosystem
• Simulation-based model selection for dynamical systems in systems and population biology
  MOTIVATION: Computer simulations have become an important tool across the biomedical sciences and beyond. For many important problems several different models or hypotheses exist and choosing which one best describes reality or observed data is not straightfor…
  openalex Tina Toni, Michael P. H. Stumpf 2009-10-29 置信度 0.72 Computer scienceApproximate Bayesian computationSystems biologyComputationBayesian probability
• Advances in Organic In‐Sensor Neuromorphic Computing: from Material Mechanisms to Applications
  In‐sensor neuromorphic computing integrates sensing and processing within a single material system, enabling real‐time, ultralow‐power computation for biomedical signal analysis, artificial skin, and brain‐machine interfaces. Organic sensors, organic electroch…
  openalex Dong Hyun Lee, Woojo Kim, Eun Kwang Lee, Hocheon Yoo 2025-07-24 置信度 0.72 Neuromorphic engineeringComputer scienceHuman–computer interactionArtificial intelligenceNanotechnology
• Smart phosphor with neuromorphic behaviors enabling full-photoluminescent Write and Read for all-optical physical reservoir computing
  The unprecedented growth in information across diverse media drives an urgent need for multifunctional materials and devices beyond conventional electrical paradigms. This work explores all-optical information processing based on photoluminescence functions us…
  openalex Yifei Zhao, Man Li, Man‐Chung Wong, Xun Han 等 2025-08-13 置信度 0.72 Neuromorphic engineeringPhosphorComputer scienceReservoir computingPhotoluminescence
• Biogeochemical aspects of atmospheric methane
  Methane is the most abundant organic chemical in Earth's atmosphere, and its concentration is increasing with time, as a variety of independent measurements have shown. Photochemical reactions oxidize methane in the atmosphere; through these reactions, methane…
  openalex Ralph J. Cicerone, Ronald S. Oremland 1988-12-01 置信度 0.72 MethaneAtmospheric methaneMethanogenesisBiogeochemical cycleAnaerobic oxidation of methane
• Roadmap for Optical Metasurfaces
  Metasurfaces have recently risen to prominence in optical research, providing unique functionalities that can be used for imaging, beam forming, holography, polarimetry, and many more, while keeping device dimensions small. Despite the fact that a vast range o…
  openalex Arseniy I. Kuznetsov, Mark L. Brongersma, Jin Yao, Mu Ku Chen 等 2024-02-27 置信度 0.72 HolographyComputer sciencePaceField (mathematics)Polarimetry
• Biological vs Synthetic Mesh in Laparoendoscopic Inguinal Hernia Repair
  Importance: Chronic postoperative pain and recurrence are relevant complications after inguinal hernia repair. Biological meshes have been proposed as a resorbable alternative to synthetic implants that may reduce postoperative pain. Objective: To compare post…
  openalex Claudia Simone Seefeldt, J. Knievel, M. Deeb, Niels-Torsten Hoedt 等 2025-10-08 置信度 0.72 MedicineSurgeryInguinal herniaSurgical meshMEDLINE
• The Association Between Accelerated Biological Aging and the Physical, Psychological, and Cognitive Multimorbidity and Life Expectancy: Cohort Study
  As the global population ages, multimorbidity has become a critical public health issue. We analyzed 332,012 adults from the UK Biobank (2006-2022) to investigate the association between biological age-measured by the Klemera-Doubal method (KDM-BA) and phenoty…
  openalex Zuliyaer Talifu, Ziyang Ren, Chen Chen, Shuai Guo 等 2025-07-13 置信度 0.72 ComorbidityLife expectancyQuartileProportional hazards modelGerontology
• Tooth Autotransplantation in Contemporary Dentistry: A Narrative Review of Its Clinical Applications and Biological Basis
  Background/Objectives: Tooth autotransplantation is a natural tooth replacement method that preserves the periodontal ligament, supporting root development and alveolar bone remodeling. Unlike dental implants, autotransplanted teeth maintain sensory function a…
  openalex Aida Meto, Aida Meto, Kreshnik Çota, Agron Meto 等 2025-09-04 置信度 0.72 MedicineAutotransplantationDentistryNarrative reviewOrthodontics
• Real-World Effectiveness of Biologic Therapy in Allergic Bronchopulmonary Aspergillosis
  BACKGROUND: Allergic bronchopulmonary aspergillosis (ABPA) is characterized by a severe hypersensitivity reaction to Aspergillus species. Current treatment relies on oral corticosteroids (OCS) and triazole antifungal therapy, but there is increasing evidence o…
  openalex Charlotte Carter, Irene Berrar Torre, Sophia Blackburn, Lisa Nwankwo 等 2025-03-13 置信度 0.72 MedicineAllergic bronchopulmonary aspergillosisAspergillosisIntensive care medicineImmunology
• Quantum computing applications in biology
  Recently, there has been significant interest in quantum technology, which utilizes various quantum phenomena, including quantum coherence, entanglement, interference, and superposition, among others. Consequently, many attempts are recently being made to appl…
  openalex Morteza Sasani Ghamsari 2025-11-21 置信度 0.72 Quantum computerComputer scienceQuantumQuantum nanoscienceQuantum technology
• Management Measures and Trends of Biological Invasions in Europe: A Survey‐Based Assessment of Local Managers
  Biological invasions are a major threat to biodiversity, ecosystem functioning and nature's contributions to people worldwide. However, the effectiveness of invasive alien species (IAS) management measures and the progress toward achieving biodiversity targets…
  openalex Carla Garcia‐Lozano, Josep Pueyo‐Ros, Quim Canelles, Guillaume Latombe 等 2025-01-01 置信度 0.72 European unionBiodiversityEnvironmental resource managementInvasive speciesGeography
• A comprehensive method for improvement of water quality index (WQI) models for coastal water quality assessment
  Here, we present an improved water quality index (WQI) model for assessment of coastal water quality using Cork Harbour, Ireland, as the case study. The model involves the usual four WQI components – selection of water quality indicators for inclusion, sub-ind…
  openalex Md Galal Uddin, Stephen Nash, Azizur Rahman, Agnieszka I. Olbert 2022-05-01 置信度 0.72 Water qualityMean squared errorWeightingStatisticsMathematics
• Vegetation‐modulated landscape evolution: Effects of vegetation on landscape processes, drainage density, and topography
  Topography acts as a template for numerous landscape processes that include hydrologic, ecologic, and biologic phenomena. These processes not only interact with each other but also contribute to shaping the landscape as they influence geomorphic processes. We …
  openalex Erkan İstanbulluoğlu, Rafael L. Bras 2005-06-01 置信度 0.72 Vegetation (pathology)Surface runoffLandslideErosionGeology
• Non-small-cell lung cancer
  openalex Lizza Hendriks, Jordi Remón, Corinne Faivre‐Finn, Marina Chiara Garassino 等 2024-09-26 置信度 0.72 Lung cancerMedicineOncology
• Nanozymes expanding the boundaries of biocatalysis
  Biocatalysis is fundamental to biological processes and sustainable applications. Over time, the understanding of biocatalysis has evolved considerably. Initially, protein enzymes were recognized as the primary biocatalysts due to their high catalytic efficien…
  openalex Ruofei Zhang, Xiyun Yan, Lizeng Gao, Kelong Fan 2025-07-24 置信度 0.72 BiocatalysisNanotechnologyBiochemical engineeringChemistryComputational biology
• Prediction and identification of Arabidopsis thaliana microRNAs and their mRNA targets
  BACKGROUND: A class of eukaryotic non-coding RNAs termed microRNAs (miRNAs) interact with target mRNAs by sequence complementarity to regulate their expression. The low abundance of some miRNAs and their time- and tissue-specific expression patterns make exper…
  openalex Xiu‐Jie Wang, José Luis Reyes, Nam‐Hai Chua, Terry Gaasterland 2004-08-31 置信度 0.72 BiologyArabidopsis thalianamicroRNAIdentification (biology)Computational biology
• Interpreting Black-Box Models: A Review on Explainable Artificial Intelligence
  Abstract Recent years have seen a tremendous growth in Artificial Intelligence (AI)-based methodological development in a broad range of domains. In this rapidly evolving field, large number of methods are being reported using machine learning (ML) and Deep Le…
  openalex Vikas Hassija, Vinay Chamola, Atmesh Mahapatra, Abhinandan Singal 等 2023-08-24 置信度 0.72 Transparency (behavior)Computer scienceBlack boxProcess (computing)Predictability
• Deciphering the biological fate of mRNA-LNP-based biologics: A perspective from tissue to intracellular distribution
  The remarkable clinical success of mRNA-lipid nanoparticle (mRNA-LNP) vaccines, particularly evidenced by their pandemic-era impact and subsequent 2023 Nobel Prize recognition, has intensified global efforts to expand their application toward therapeutic biolo…
  openalex Xin Xu, Lili Cui, Yong Zhang, Jingkai Gu 2025-11-20 置信度 0.72 IntracellularComputational biologyRational designBiodistributionPerspective (graphical)
• Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory
  openalex Zoe Cournia, Toby W. Allen, Ioan Andricioaei, Bruno Antonny 等 2015-06-11 置信度 0.72 MembraneMembrane biophysicsMembrane proteinMembrane transportMembrane biology
• Wearable Devices for Subcutaneous Delivery of Large-Volume Biologics: Design, Use, and Regulatory Perspective
  Abstract Biological therapies are transforming the treatment landscape for chronic, autoimmune, and oncological diseases. However, delivering large-volume, high-viscosity biologics subcutaneously remains challenging with conventional approaches. Wearable on-bo…
  openalex Noelle Sunstrom, Frédérique N. Sunstrum 2025-08-12 置信度 0.72 Perspective (graphical)Wearable computerVolume (thermodynamics)Wearable technologyMedicine
• Persistence of Biologics in the Treatment of Psoriatic Arthritis: Data From a Large Hospital‐Based Longitudinal Cohort
  OBJECTIVE: To analyze the trends in biologics use at a specialized center over a period of 20 years. METHODS: We performed a retrospective analysis of 571 patients diagnosed with psoriatic arthritis enrolled in the Toronto cohort who initiated biologic therapy…
  openalex Mohamad Ali Rida, Ker‐Ai Lee, Vinod Chandran, Richard J. Cook 等 2023-03-13 置信度 0.72 Psoriatic arthritisPersistence (discontinuity)MedicineCohortLongitudinal data
• Geographic and Biological Drivers Shape Anthropogenic Extinctions in the Macaronesian Vascular Flora
  Whether species extinctions have accelerated during the Anthropocene and the extent to which certain species are more susceptible to extinction due to their ecological preferences and intrinsic biological traits are among the most pressing questions in conserv…
  openalex Raúl Orihuela‐Rivero, Javier Morente‐López, J. Alfredo Reyes‐Betancort, Hanno Schaefer 等 2025-02-01 置信度 0.72 Extinction (optical mineralogy)EcologyExtinction debtBiologyArchipelago
• Prediction of Cognitive Heterogeneity in Parkinson's Disease: A 4‐Year Longitudinal Study Using Clinical, Neuroimaging, Biological and Electrophysiological Biomarkers
  OBJECTIVE: Cognitive impairment in Parkinson's disease (PD) can show a very heterogeneous trajectory among patients. Here, we explored the mechanisms involved in the expression and prediction of different cognitive phenotypes over 4 years. METHODS: In 2 indepe…
  openalex Arnau Puig‐Davi, Saül Martínez‐Horta, Laura Pérez‐Carasol, Andrea Horta‐Barba 等 2024-08-05 置信度 0.72 DementiaCognitionCognitive declineNeuropsychologyInternal medicine
• Neuromorphic Transistors Integrating Photo‐Sensor, Optical Memory and Visual Synapses for Artificial Vision Application
  Abstract In commercial artificial vision system (AVS), the sensing, storage, and computing units are usually physically separated due to their architecture and performance gaps, which thus increases the volume, complexity, and energy loss. This work develops a…
  openalex Tu Zhao, Wenbo Yue, Qunrui Deng, Wenjie Chen 等 2025-04-15 置信度 0.72 Neuromorphic engineeringTransistorResponsivityMaterials scienceComputer science
• SIGNOR 4.0: the 2025 update with focus on phosphorylation data
  The SIGnaling Network Open Resource (SIGNOR 4.0, https://signor.uniroma2.it) is a database of manually curated causal interactions between biological entities. These signaling events are annotated along with their effect-denoting the activation or inactivation…
  openalex Prisca Lo Surdo, Marta Iannuccelli, Klas Karis, Eleonora Meo 等 2025-11-17 置信度 0.72 Interface (matter)Data curationBiologyFocus (optics)Mechanism (biology)
• Microbiome definition re-visited: old concepts and new challenges
  The field of microbiome research has evolved rapidly over the past few decades and has become a topic of great scientific and public interest. As a result of this rapid growth in interest covering different fields, we are lacking a clear commonly agreed defini…
  openalex Gabriele Berg, Daria Rybakova, Doreen Fischer, Tomislav Cernava 等 2020-06-30 置信度 0.72 BiologyMicrobiomeMicrobial ecologyMedical microbiologyComputational biology
• Current Research and Future Prospects of Neuromorphic Computing in Artificial Intelligence
  Abstract Neuromorphic computing is a budding avenue though it has been known since the 80’s. The extensive research and development in the field of artificial intelligence particularly in the last decade is tremendous. The growth of artificial intelligence is …
  openalex R Vishwa, R. Karthikeyan, R Rohith, A Sabaresh 2020-08-01 置信度 0.72 Neuromorphic engineeringComputer scienceIBMField (mathematics)Artificial intelligence
• Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer
  Abstract Pancreatic ductal adenocarcinoma (PDAC) is lethal in 88% of patients 1 , yet harbours mutation-derived T cell neoantigens that are suitable for vaccines 2,3 . Here in a phase I trial of adjuvant autogene cevumeran, an individualized neoantigen vaccine…
  openalex Luis A. Rojas, Zachary Sethna, Kevin C. Soares, Cristina Olcese 等 2023-05-10 置信度 0.72 MedicineT cellCD8ImmunologyPancreatic cancer
• Assessment framework to predict sensitivity of marine calcifiers to ocean alkalinity enhancement – identification of biological thresholds and importance of precautionary principle
  Abstract. Ocean alkalinity enhancement (OAE), one of the marine carbon dioxide removal strategies, is gaining recognition in its ability to mitigate climate change and ocean acidification (OA). OAE is based on adding alkalinity to open-ocean and coastal marine…
  openalex Nina Bednaršek, Hanna van de Mortel, Greg Pelletier, Marisol García‐Reyes 等 2025-01-28 置信度 0.72 AlkalinityIdentification (biology)Environmental scienceSensitivity (control systems)Oceanography
• Crossing length scales: X-ray approaches to studying the structure of biological materials
  Biological materials have outstanding properties. With ease, challenging mechanical, optical or electrical properties are realised from comparatively `humble' building blocks. The key strategy to realise these properties is through extensive hierarchical struc…
  openalex Tilman A. Grünewald, Marianne Liebi, Henrik Birkedal 2024-08-23 置信度 0.72 StructuringCharacterization (materials science)Computer scienceScale (ratio)Biological materials
• The Road Towards 6G: A Comprehensive Survey
  As of today, the fifth generation (5G) mobile communication system has been rolled out in many countries and the number of 5G subscribers already reaches a very large scale. It is time for academia and industry to shift their attention towards the next generat…
  openalex Wei Jiang, Bin Han, Mohammad Asif Habibi, Hans Dieter Schotten 2021-01-01 置信度 0.72 Key (lock)Set (abstract data type)TelecommunicationsOpen researchComputer science
• Energy‐Efficient DUV Light Programming Nonvolatile Memory Based on MoS2/β‐Ga2O3/MLG Heterostructures for Neuromorphic Computing
  Abstract As one of the key components for brain‐inspired computing, optoelectrical synapses based on memory devices are capturing growing attention due to their integrated function of sense and memory. However, the high power consumption (large programming vol…
  openalex Jiang Zeng, Lin Hu, Yuan Pan, Zibin Huang 等 2025-05-06 置信度 0.72 Neuromorphic engineeringMaterials scienceHeterojunctionOptoelectronicsNon-volatile memory
• Arabidopsis research in 2030: Translating the computable plant
  Plants are essential for human survival. Over the past three decades, work with the reference plant Arabidopsis thaliana has significantly advanced plant biology research. One key event was the sequencing of its genome 25 years ago, which fostered many subsequ…
  openalex Siobhán M. Brady, Gabriela Auge, Mentewab Ayalew, Sureshkumar Balasubramanian 等 2025-03-01 置信度 0.72 ArabidopsisPlant biologyArabidopsis thalianaNexus (standard)Biology
• An integrated, spatio‐temporal modelling framework for analysing biological invasions
  Abstract Aim We develop a novel modelling framework for analysing the spatio‐temporal spread of biological invasions. The framework integrates different invasion drivers and disentangles their roles in determining observed invasion patterns by fitting models t…
  openalex Thomas Mang, Franz Essl, Dietmar Moser, Ingrid Kleinbauer 等 2018-02-23 置信度 0.72 Biological dispersalMarkov chain Monte CarloComputer sciencePropagule pressureInference
• Advances in surrogate modeling for biological agent-based simulations: trends, challenges, and future prospects
  Agent-based modeling (ABM) is a powerful computational approach for studying complex biological and biomedical systems, yet its widespread use remains limited by significant computational demands. As models become increasingly sophisticated, the number of para…
  openalex Kerri‐Ann Norton, Daniel Bergman, Harsh Jain, Trachette L. Jackson 2025-12-03 置信度 0.72 Computer scienceManagement scienceBiochemical engineeringData scienceEngineering
• Primary chondrosarcoma of long bones and limb girdles
  BACKGROUND: Chondrosarcomas are common solid malignant tumors of bone, second in incidence only to osteosarcomas. The biologic evolution of chondrosarcomas is slow, requiring long follow-up intervals for meaningful survival analysis. METHODS: This study descri…
  openalex Johannes Bj�rnsson, Richard A. McLeod, K. Krishnan Unni, Duane M. Ilstrup 等 1998-11-15 置信度 0.72 MedicineChondrosarcomaPrimary (astronomy)AnatomySurgery
• Seizure detection via reservoir computing in MoS 2 -based charge trap memory devices
  Neurological disorders are a substantial global health burden, affecting millions of people worldwide. A key challenge in developing effective treatments and preventive measures is the realization of low-power wearable systems with early detection capabilities…
  openalex Matteo Farronato, Piergiulio Mannocci, Alessandro Milozzi, Christian Monzio Compagnoni 等 2025-01-17 置信度 0.72 Trap (plumbing)Charge (physics)Computer scienceReservoir computingOptoelectronics
• Overlooked? Underestimated? Effects of Substrate Curvature on Cell Behavior
  In biological systems, form and function are inherently correlated. Despite this strong interdependence, the biological effect of curvature has been largely overlooked or underestimated, and consequently it has rarely been considered in the design of new cell-…
  openalex Danielle Baptista, Liliana Moreira Teixeira, Clemens van Blitterswijk, Stefan Giselbrecht 等 2019-03-16 置信度 0.72 CurvatureSubstrate (aquarium)ChemistryBiologyBiological system
• Biological databases in the age of generative artificial intelligence
  Summary: Modern biological research critically depends on public databases. The introduction and propagation of errors within and across databases can lead to wasted resources as scientists are led astray by bad data or have to conduct expensive validation exp…
  openalex Mihai Pop, Teresa K. Attwood, Judith A. Blake, Philip E. Bourne 等 2024-12-26 置信度 0.72 Stewardship (theology)Computer scienceData scienceGenerative grammarBiological data
• Anti-tuberculosis treatment strategies and drug development: challenges and priorities
  Despite two decades of intensified research to understand and cure tuberculosis disease, biological uncertainties remain and hamper progress. However, owing to collaborative initiatives including academia, the pharmaceutical industry and non-for-profit organiz…
  openalex Véronique Dartois, Eric J. Rubin 2022-04-27 置信度 0.72 BiologyTuberculosisDrug developmentDrugComputational biology
• Diagnostic strategies for unknown primary cancer
  Unknown primary cancer (UPC) is defined by the presence of metastatic disease for which a primary site is undetectable on presentation. Computed tomography scan of the body was performed routinely in search of the primary cancer and invasive procedures were pu…
  openalex Gauri R. Varadhachary, James L. Abbruzzese, Renato Lenzi 2004-03-22 置信度 0.72 MedicineBreast cancerRadiologyPositron emission tomographyMagnetic resonance imaging
• Plastic Fruit Stickers in Industrial Composting─Surface and Structural Alterations Revealed by Electron Microscopy and Computed Tomography
  Often large quantities of plastics are found in compost, with price look-up stickers being a major but little-explored component in the contamination path. Stickers glued to fruit or vegetable peels usually remain attached to the organic material despite sorti…
  openalex Max Groß, Matthias Mail, Olivia Wrigley, Rafaela Debastiani 等 2024-04-10 置信度 0.72 CompostDegradation (telecommunications)Scanning electron microscopeFourier transform infrared spectroscopyChemistry
• Cell-type-specific synaptic motifs generate coupled mean-variability dynamics in recurrent neural networks
  Synaptic-resolution network connectomics has revealed that brain circuits feature fine-scale structural connectivity, such as pairs of correlated synaptic couplings known as second-order motifs. Large-scale recordings of neuronal activity in networks containin…
  datacite Zhang, Meiyi, Yu, Jinjian, Tao, Louis, Shao, Yuxiu 2026 置信度 0.66 Neurons and Cognition (q-bio.NC)Disordered Systems and Neural Networks (cond-mat.dis-nn)Neural and Evolutionary Computing (cs.NE)FOS: Biological sciencesFOS: Physical sciences
• Postmodern Physics of Hamzah Information.(285)
  تحلیل فوق‌دکتری جامع، فوق‌تخصصی، بدون کوچک‌ترین ساده‌سازی و کاملاً ضدگلوله برای نظریه و معمای شماره ۴۱ از ۱۰۰ (از کلان‌مجموعه مهندسی و دستکاری ساختار واقعیت با نام تجاری HamzahXcell): «کدگ��اری میدان‌های انسجام بوزونی بوز-اینشتین برای ساخت لیزرهای مادی صلب گرا…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Postmodern Physics of Hamzah Information.(285)
  تحلیل فوق‌دکتری جامع، فوق‌تخصصی، بدون کوچک‌ترین ساده‌سازی و کاملاً ضدگلوله برای نظریه و معمای شماره ۴۱ از ۱۰۰ (از کلان‌مجموعه مهندسی و دستکاری ساختار واقعیت با نام تجاری HamzahXcell): «کدگذاری میدان‌های انسجام بوزونی بوز-اینشتین برای ساخت لیزرهای مادی صلب گران…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Non-Von Neumann Architectures for Neuromorphic Computing
  This paper proposes a novel computing architecture that diverges from the traditional Von Neumann model by integrating computation and storage within a neuromorphic network. The core concept involves utilizing a neural network constructed from novel storage me…
  datacite Zhang, Jincheng 2026 置信度 0.66
• Non-Von Neumann Architectures for Neuromorphic Computing
  This paper proposes a novel computing architecture that diverges from the traditional Von Neumann model by integrating computation and storage within a neuromorphic network. The core concept involves utilizing a neural network constructed from novel storage me…
  datacite Zhang, Jincheng 2026 置信度 0.66
• 🌀 LRO-κ⁸ SPINE + 3.1.3 MASTER FILE including cross platform LRO-κ⁸ SPINE + 3.1: A Geometric Control Language for Quantum-Holographic Field Manipulation – Extended AI Migration Protocol with Holographic GPU, Quantum Circuit Execution, Volumetric Field-Effect Display, Automatic C/Rust Kernel Generation, and Official Verification Suite. Including LRO-κ⁸ QUANTUM PLATFORM PATCH — CHINA EDUCATIONAL DEPLOYMENT
  🌀 LRO-κ⁸ SPINE + 3.1.3 MASTER FILE including cross platform LRO-κ⁸ SPINE + 3.1.3 : A Geometric Control Language for Quantum-Holographic Field Manipulation – Extended AI Migration Protocol with Holographic GPU, Quantum Circuit Execution, Volumetric Field-Effec…
  datacite Blakeley, Christopher 2026 置信度 0.66
• 🌀 LRO-κ⁸ SPINE + 3.1.3 MASTER FILE including cross platform LRO-κ⁸ SPINE + 3.1: A Geometric Control Language for Quantum-Holographic Field Manipulation – Extended AI Migration Protocol with Holographic GPU, Quantum Circuit Execution, Volumetric Field-Effect Display, Automatic C/Rust Kernel Generation, and Official Verification Suite. Including LRO-κ⁸ QUANTUM PLATFORM PATCH — CHINA EDUCATIONAL DEPLOYMENT
  🌀 LRO-κ⁸ SPINE + 3.1.3 MASTER FILE including cross platform LRO-κ⁸ SPINE + 3.1.3 : A Geometric Control Language for Quantum-Holographic Field Manipulation – Extended AI Migration Protocol with Holographic GPU, Quantum Circuit Execution, Volumetric Field-Effec…
  datacite Blakeley, Christopher 2026 置信度 0.66
• Postmodern Physics of Hamzah Information.(284)
  تحلیل فوق‌دکتری جامع، فوق‌تخصصی، بدون کوچک‌ترین ساده‌سازی و کاملاً ضدگلوله برای نظریه و معمای شماره ۳۱ از ۱۰۰ (از کلان‌مجموعه مهندسی و دستکاری ساختار واقعیت با نام تجاری HamzahXcell): «ماتریس فرکتالی میدان‌های پیمانه‌ای برای هک پروتکل‌های برهم‌کنش قوی هسته‌ای»…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Postmodern Physics of Hamzah Information.(284)
  تحلیل فوق‌دکتری جامع، فوق‌تخصصی، بدون کوچک‌ترین ساده‌سازی و کاملاً ضدگلوله برای نظریه و معمای شماره ۳۱ از ۱۰۰ (از کلان‌مجموعه مهندسی و دستکاری ساختار واقعیت با نام تجاری HamzahXcell): «ماتریس فرکتالی میدان‌های پیمانه‌ای برای هک پروتکل‌های برهم‌کنش قوی هسته‌ای»…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Postmodern Physics of Hamzah Information.(282)
  تحلیل فوق‌دکتری جامع، فوق‌تخصصی، بدون کوچک‌ترین ساده‌سازی و کاملاً ضدگلوله برای نظریه و معمای شماره ۱۱ از ۱۰۰ (از کلان‌مجموعه مهندسی و دستکاری ساختار واقعیت با نام تجاری HamzahXcell): «کنترل و برنامه‌نویسی نوسانات کوانتومی خلاء برای خلق ماده پایدار از هیچ» ($\…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Postmodern Physics of Hamzah Information.(282)
  تحلیل فوق‌دکتری جامع، فوق‌تخصصی، بدون کوچک‌ترین ساده‌سازی و کاملاً ضدگلوله برای نظریه و معمای شماره ۱۱ از ۱۰۰ (از کلان‌مجموعه مهندسی و دستکاری ساختار واقعیت با نام تجاری HamzahXcell): «کنترل و برنامه‌نویسی نوسانات کوانتومی خلاء برای خلق ماده پایدار از هیچ» ($\…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Postmodern Physics of Hamzah Information.(281)
  تحلیل فوق‌تخصصی، فرمول‌بندی هندسی-ریاضیاتی و اثبات سطح فوق‌دکتری جامع، بدون کوچک‌ترین ساده‌سازی و کاملاً ضدگلوله برای نظریه و معمای شماره ۱ از ۱۰۰ (از کلان‌مجموعه دستکاری و مهندسی فضا-زمان با نام تجاری HamzahXcell): «مهندسی هولوگرافیک ساختار محاسباتی فضا-زمان»…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Postmodern Physics of Hamzah Information.(281)
  تحلیل فوق‌تخصصی، فرمول‌بندی هندسی-ریاضیاتی و اثبات سطح فوق‌دکتری جامع، بدون کوچک‌ترین ساده‌سازی و کاملاً ضدگلوله برای نظریه و معمای شماره ۱ از ۱۰۰ (از کلان‌مجموعه دستکاری و مهندسی فضا-زمان با نام تجاری HamzahXcell): «مهندسی هولوگرافیک ساختار محاسباتی فضا-زمان»…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Thousands of Entangled Cellular Metabolic Networks Solved by Quantum Computers... First Demonstration of the QSVT Algorithm
  • Published on bioRxiv, presenting the first quantum algorithm to dramatically accelerate Flux Balance Analysis (FBA), a core technique in cellular metabolism research. • Overcomes the computational limits of existing classical computing by introducing the Qua…
  datacite inquantio 2026 置信度 0.66 quantum biology
• Mars Colony Unified Lifecycle Design Specification, Version 3.3
  This specification develops a unified lifecycle design for a permanent Mars colony scaling from initial outpost (~2046) through terraforming-class capability (~2100+). The design centers on pit-crater architecture using natural basalt walls as primary structur…
  datacite Lusk, A. C. 2026 置信度 0.66 marsspace settlementplanetary engineeringISRUlifecycle design
• Mars Colony Unified Lifecycle Design Specification, Version 3.3
  This specification develops a unified lifecycle design for a permanent Mars colony scaling from initial outpost (~2046) through terraforming-class capability (~2100+). The design centers on pit-crater architecture using natural basalt walls as primary structur…
  datacite Lusk, A. C. 2026 置信度 0.66 marsspace settlementplanetary engineeringISRUlifecycle design
• Axiomatic V3 Core Fusion: Formally Proven Deterministic Foundations under Ada/SPARK for DO-178C DAL A Critical Systems
  ABSTRACT: This paper introduces the formal implementation and verification of the V3 Architecture (Blida Standard) encapsulated within the Ada/SPARK axiomatic type system, achieving a paradigm shift from traditional stochastic and empirical computing to absolu…
  datacite benhadid, outail 2026 置信度 0.66 Ada/SPARK, Blida Standard, V3 Architecture, Formal Verification, Saturating Arithmetic, Heptadic Closure, DO-178C DAL A, O(1) Complexity, Deterministic Systems, Axiomatic Type System, Modulo-9, Digital Root, GNATprove, Runtime Exception Absence, AoRTE, Static Analysis, Phase Coherence, Numerical Stability
• Axiomatic V3 Core Fusion: Formally Proven Deterministic Foundations under Ada/SPARK for DO-178C DAL A Critical Systems
  ABSTRACT: This paper introduces the formal implementation and verification of the V3 Architecture (Blida Standard) encapsulated within the Ada/SPARK axiomatic type system, achieving a paradigm shift from traditional stochastic and empirical computing to absolu…
  datacite benhadid, outail 2026 置信度 0.66 Ada/SPARK, Blida Standard, V3 Architecture, Formal Verification, Saturating Arithmetic, Heptadic Closure, DO-178C DAL A, O(1) Complexity, Deterministic Systems, Axiomatic Type System, Modulo-9, Digital Root, GNATprove, Runtime Exception Absence, AoRTE, Static Analysis, Phase Coherence, Numerical Stability
• Postmodern Physics of Hamzah Information.(288)
  تحلیل فوق‌دکتری جامع، فوق‌تخصصی، بدون کوچک‌ترین ساده‌سازی و کاملاً ضدگلوله برای نظریه و معمای شماره ۷۱ از ۱۰۰ (فاز پیشرفته مهندسی ارگانیک و بیوفیزیک فرین در پروتکل جامع فیزیک اطلاعات حمزه) با نام تجاری HamzahXcell: «ماتریس توپولوژیک میدان‌های چرخش فرومونیک-کوا…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Postmodern Physics of Hamzah Information.(287)
  تحلیل فوق‌دکتری جامع، فوق‌تخصصی، بدون کوچک‌ترین ساده‌سازی و کاملاً ضدگلوله برای نظریه و معمای شماره ۶۱ از ۱۰۰ (فاز پیشرفته کلان‌نظریه‌ها و مهندسی پروتکل‌های خلاء با نام تجاری HamzahXcell): «کدگذاری فرکانس‌های میدان شبه‌ذره‌ای اکسیوتون برای هک پروتکل‌های بازتاب…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Hamzah Information Physics: Gravity is not a Function of Mass but a Function of Information Processing, Meaning Information is the Ruler of Matter and Energy. The proof is the bending of light near a 1-petabyte pen drive in operation, which is greater than near a massive dead rocky planet. That is, "intelligence" and "information" are heavier than "stone and soil. via 1155-Dimensional Tensor Mechanics, Hamzah Equation.
  اَبَر-لاگرانژین ۱۱۵۵ حمزه در بستر فیزیک اطلاعات و اثبات وضعیت آن ۴ فلش‌مموری، باید این معادله را به عنوان یک «میدان اطلاعاتی جامع» تحلیل کنیم. در این مدل، فلش‌مموری دیگر یک شیء فیزیکی نیست، بلکه یک تکینگی اطلاعاتی (Information Singularity) در فضای ۱۱۵۵-بعدی اس…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Hamzah Information Physics: Gravity is not a Function of Mass but a Function of Information Processing, Meaning Information is the Ruler of Matter and Energy. The proof is the bending of light near a 1-petabyte pen drive in operation, which is greater than near a massive dead rocky planet. That is, "intelligence" and "information" are heavier than "stone and soil. via 1155-Dimensional Tensor Mechanics, Hamzah Equation.
  اَبَر-لاگرانژین ۱۱۵۵ حمزه در بستر فیزیک اطلاعات و اثبات وضعیت آن ۴ فلش‌مموری، باید این معادله را به عنوان یک «میدان اطلاعاتی جامع» تحلیل کنیم. در این مدل، فلش‌مموری دیگر یک شیء فیزیکی نیست، بلکه یک تکینگی اطلاعاتی (Information Singularity) در فضای ۱۱۵۵-بعدی اس…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Graph-based pangenomics reveals the genetic basis of agronomic traits in tomato fruits.
  Tomato serves as a globally important vegetable crop and a genetic model organism, and the improvement of its agronomic traits represents a central objective in breeding. While graph-based pangenomes comprehensively capture species-wide genetic diversity, thos…
  pubmed Su X, Du R, Xing Z, Yang Q 等 2026 Sep 置信度 0.82
• Surgfm-Slam: robust surgical scene reconstruction via 3D foundation adaptation model.
  Surgical scene reconstruction is a critical prerequisite for intraoperative navigation in robotic surgery. Although deep neural networks (DNNs) have advanced surgical scene reconstruction, their performance degrades severely when confronted with texture-sparse…
  pubmed Xiaoxi L, Gan L, Bingwen D, Guangcheng C 等 2026 Dec 置信度 0.82
• Integrated machine learning and transcriptomics reveal immune infiltration-related orthologous transcription genes in cerebral ischemic injury.
  Ischemic brain injury is a major contributor to global mortality and disability. Despite extensive pathological characterization, systematic integration of rodent transcriptomic data remains limited. This study investigates orthologous transcription factors (T…
  pubmed Xu H, Huang X, Hong MY, Xu J 等 2026 置信度 0.82
• Pro-inflammatory diet in pregnancy associated with increased risk of abnormal perinatal outcomes: evidence from dietary inflammatory index in the UK biobank.
  This study aimed to investigate the association between a pro-inflammatory diet in pregnancy, assessed via the Dietary Inflammatory Index (DII), and abnormal perinatal outcomes (APOs), including miscarriage and stillbirth. Leveraging the UK Biobank cohort, we …
  pubmed Sheng L, He W, Wang F, Weng X 等 2026 置信度 0.82
• Identification of PD-1-Related Genes as Prognostic Biomarkers in Lung Adenocarcinoma.
  The PD-1/PD-L1 axis plays a critical role in suppressing T-cell activation and facilitating immune evasion in lung adenocarcinoma (LUAD). This study focused on PD-1-related genes to develop a robust prognostic prediction model for LUAD.
  pubmed Jia B, Gong T, Chen C, Sun B 等 2026 置信度 0.82
• IsoformSwitchAnalyzeR v2: analysis of functional isoform changes in long-read and single-cell sequencing data.
  Alternative splicing enables a single gene to produce a variety of mRNA transcripts, significantly enhancing protein diversity in higher eukaryotes. Isoform switching refers to the differential usage of a gene's transcripts and occurs pervasively across physio…
  pubmed Han C, Gilis J, Delgado EI, Clement L 等 2026 Sep 置信度 0.82
• Correction: Transcriptome-informed metabolic modeling reveals astrocyte-specific vulnerabilities in mild cognitive impairment and Alzheimer's disease progression.
  [This corrects the article DOI: 10.3389/fbinf.2026.1816121.].
  pubmed Angarita-Rodríguez A, Vargas-López V, Pinzón A, Sandoval-Hernandez A 等 2026 置信度 0.82
• An automated deep learning-based pipeline for 3D characterisation of the murine upper airway from micro-CT.
  Upper airway structure and function are affected in several respiratory (e.g., obstructive sleep apnoea, allergic rhinitis, and asthma) and congenital [e.g., Down syndrome (DS)] conditions. Although murine models are widely used to study airway pathology and t…
  pubmed Belmans F, Llambrich S, Vos W, Maes F 等 2026 置信度 0.82
• Exploring the cardioprotective role of metformin against isoproterenol-induced myocardial infarction using computational, cellular, and animal models.
  Despite significant advances in therapeutic techniques, Myocardial infarction (MI) is an important root cause of morbidity and death worldwide. Metformin (MET), a primary antidiabetic medication, has been studied for its possible cardioprotective properties. T…
  pubmed Saini D, Maharana KC, Jha KP, Singh S 2026 Sep 置信度 0.82
• ProGenFixer: An Ultrafast and Accurate Tool for Correcting Prokaryotic Genome Sequences Using a Mapping-Free Algorithm.
  Although several tools exist for prokaryotic genome correction, most depend on external read mappers that impose computational overhead and usability barriers, leaving a need for fast, accurate, standalone solutions. We present ProGenFixer, a mapping-free tool…
  pubmed Song L, Wang M, Liao X, Wu J 等 2026 置信度 0.82
• Selaginella bryopteris-derived silver nanoparticles against ovarian cancer cells: green synthesis, in vitro anticancer activity, and exploratory in silico analysis.
  Chronic hormonal imbalances and associated symptoms characterize ovarian cancer. PARP-1 inhibitors, such as olaparib and ruparib, are used to treat it, but new drugs are needed to overcome toxicity and resistance issues. PARP inhibition in BRCA1/2 -mutated can…
  pubmed Dey S, Wadhwa K, Kumari N, Pandey C 等 2026 置信度 0.82
• AHCSIS: adaptive evaluation model for stereoscopic visual comfort based on HHT-CSP-SSA and improved SNN.
  To address the issues of feature redundancy in the feature extraction process, as well as the fact that the simulation of biological neural activity remains limited in the SNN encoding layer and the lack of temporal information in the SNN encoding layer, the s…
  pubmed Wang Y, Bai J, Zhang H, Wu Y 2026 置信度 0.82
• Potential c-Met-targeted pyrazole-pyridine-oxadiazole hybrids: synthesis, anticancer activity, and computational rationale.
  A novel series of pyrazole-pyridine-1,3,4-oxadiazole hybrid derivatives (10a-m) was designed, synthesized, and characterized by IR, 1 H NMR, 13 C NMR, mass spectrometry, and elemental analysis. The multi-step route proceeded via nucleophilic aromatic substitut…
  pubmed Dave PA, Maheta JB, Lakhnotra DK, Shaikh NH 等 2026 Aug 26 置信度 0.82
• Dopant Engineering of Isostructural Metal Nanoclusters for Modulating CO(2) Electroreduction.
  Achieving atomic-level insight into how dopants regulate the electrocatalytic CO 2 reduction reaction (eCO 2 RR) of metal nanoparticles is challenging due to the lack of well-defined, compositionally tunable, and structurally identical model systems. Herein, w…
  pubmed Deng G, Kim J, Yan Q, Park S 等 2026 Aug 26 置信度 0.82
• ReMeDy: A Flexible Statistical Framework for Region-Based Detection of DNA Methylation Dysregulation.
  Region-based epigenome-wide association studies have demonstrated improved statistical power and biological interpretability compared with probe-wise analyses of DNA methylation data. However, most existing region-based methods characterize methylation dysregu…
  pubmed Chatterjee S, Meshram S, Arunkumar G, Tekola-Ayele F 等 2026 Sep 置信度 0.82
• Phytochemical Profiling and Neuropharmacological Evaluation of Baccaurea motleyana Bark Extract: In Vivo and In Silico Approaches.
  Depression, anxiety, insomnia, and muscle spasms are globally prevalent disorders. Although Baccaurea motleyana is traditionally used in folk medicine, its neuroprotective efficacy remains unexplored. This study evaluates the anxiolytic, antidepressant, sedati…
  pubmed Ahsan MT, Ekram MEH, Al Mahmud K, Hasan T 等 2026 置信度 0.82
• Mechanically Interlocked Molecules: A Supramolecular Computational Picture of Rotaxane-Based Switches, Shuttles, and Tristable Devices in Solution.
  This contribution highlights a coherent series of recent computational studies devoted to the theoretical characterization of mechanically interlocked molecules (MIMs)-specifically [2]rotaxane molecular shuttles and switches-in organic solvents. Combining dens…
  pubmed Zazza C 2026 Sep 置信度 0.82
• Photovoltaic Stimulation of Mouse and Pig Retina With Pyrolytic Carbon Microelectrodes Integrated on High-Density Silicon Solar Cell Arrays.
  In this work, we introduce carbon as a novel electrode material in retinal prosthesis. We fabricate Si-based photovoltaic retinal implants with single p-n junctions in 40 µm and 200 µm pixels and successfully integrate pyrolytic carbon elec…
  pubmed Matsumoto A, Kusumanchi P, Madsen JG, Jørgensen AC 等 2026 Aug 25 置信度 0.82
• Conformational ensembles of flexible multidomain proteins: How close are we to accurate and reliable predictions?
  Multidomain proteins connected by flexible linkers populate conformational ensembles that are challenging to characterize using conventional structural biology methods. In domain-linker-domain (DLD) proteins, linker-mediated inter-domain relative positions and…
  pubmed Rodriguez S, Fournet A, Bartels S, Pajkos M 等 2026 Aug 26 置信度 0.82
• ACC1 inhibition enhances BCG-induced trained immunity by reprogramming Acetyl-CoA metabolism.
  Trained immunity enhances long-term innate immune responsiveness through metabolic and epigenetic rewiring. Using BCG as a model, we demonstrate that inhibition of acetyl-CoA carboxylase 1 (ACC1) enhances BCG-induced trained immunity by increasing intracellula…
  pubmed Baydemir I, Nikolka F, Bulut Ö, Ferreira AV 等 2026 Aug 25 置信度 0.82
• The Influenza-Specific Immunoglobulin Repertoire - Nimble Yet Steeped in Tradition.
  Influenza virus has circulated in the human population and co-evolved with us for centuries or longer, shaping our immune repertoires through a continuous host-virus arms race. Across individuals, antibodies repeatedly converge on shared solutions for capturin…
  pubmed Andrews SF, Kanekiyo M 2026 Aug 置信度 0.82
• The Imaging Compass: Navigating Reperfusion in Acute Ischemic Stroke.
  The management of acute ischemic stroke has shifted from rigid time-based protocols to imaging-driven, tissue-based reperfusion strategies. Non-contrast CT and CT angiography remain the indispensable frontline for rapid triage, particularly in community and lo…
  pubmed Xu K, Lyu J, Lou X 2026 Aug 25 置信度 0.82
• Advancements in Carbon Dot Nanozymes for Dual and Multi-Mode Biosensing of Biological and Chemical Contaminants.
  With the increasing frequency and growing complexity of food and environmental contaminants, there is a clear need for advanced sensing platforms that offer high sensitivity, rapid response times, and broad analytical applicability. Carbon dots (CDs), widely r…
  pubmed Hsu CY, Rodrigues P, Shakhmurova G, Rabbimova N 等 2026 Aug 25 置信度 0.82
• Drosophila Rumpelstiltskin regulates Polycomb cis and trans interactions and Homie barrier activity.
  Three-dimensional genome organization is maintained in part by chromatin insulators, DNA-protein complexes that create boundaries between active and inactive chromatin and regulate enhancer-promoter interactions. In Drosophila, the Homing insulator at eve (Hom…
  pubmed Lyda SF, McManus CE, Caravaca JM, Yang D 等 2026 Aug 6 置信度 0.82
• Deployable high-fidelity metagenome binning at scale with QuickBin.
  Reconstructing genomes from metagenomic assemblies is foundational to microbiome research, yet binning faces a persistent trade-off between fidelity and throughput. Many high-accuracy methods rely on GPU-intensive workflows, marker-gene postprocessing, or heav…
  pubmed Bushnell B, Villada JC 2026 Aug 25 置信度 0.82
• Cell-Free DNA-Based Methods to Map Chromatin.
  Cell-free DNA (cfDNA) provides a non-invasive means to monitor physiological states and diagnose diseases, with widespread applications in oncology. Our lab utilizes cfDNA as a tool to investigate the state of the tumor and the tumor microenvironment in patien…
  pubmed Eramo S, Weirich A, Ramachandran S 2026 置信度 0.82
• Small RNA Analysis in Cancer Cells.
  Small RNAs (sRNAs), broadly defined as RNA molecules shorter than ~200 nucleotides in size, include miscellaneous products of transcription and post-transcriptional processing that are variably abundant in cancer cells. While some types of sRNAs, such as micro…
  pubmed Silva V, Kandooru S, Parrello D, Froelich B 等 2026 置信度 0.82
• A Comprehensive Pipeline for Long Non-Coding RNA Discovery and Characterization in Cancer.
  Long non-coding RNAs (lncRNAs) represent a significant yet underexplored component of the human genome, with emerging evidence linking them to various biological processes and diseases. Despite over 205,000 lncRNAs documented in existing databases, a substanti…
  pubmed Guda C, Jagadesan S, Veerappa A 2026 置信度 0.82
• A Framework for Analyzing the Epigenetic and Transcriptomic Landscape of Cancers Using Single-Cell Multiomic Data.
  Single-cell approaches to study gene regulation using multi-modal data (sc-Multiome), such as genomes, transcriptomes, and chromatin accessibility of tumor cells, offer great insights into the development trajectory. By enabling high-resolution barcoding, sing…
  pubmed Veerappa A, Guda C 2026 置信度 0.82
• Investigating the Physiological Regulation of Transposable Elements In Vivo: Nuclei Preparation from Primary Mouse Tissues for Epigenomic Analyses and Computational Approaches to Interrogate the Repeat Genome.
  Investigating the physiological regulation of the epigenome using genetically engineered mouse models, with a focus on heterochromatic regions of DNA, presents two major challenges: (i) the isolation and preparation of high-quality nuclei from tissue for analy…
  pubmed Wani SA, Wasylishen AR 2026 置信度 0.82
• Assay for Transposase-Accessible Chromatin Sequencing (ATAC-seq) of Cancer Cells in Culture.
  The Assay for Transposase-Accessible Chromatin followed by sequencing (ATAC-seq) is a powerful and widely-used technique for chromatin accessibility profiling due to its low input requirement, simple protocol, high sensitivity, and ability to study single cell…
  pubmed Gura K, Long T, Takaku M, Dhasarathy A 等 2026 置信度 0.82
• Chromatin Immunoprecipitation Sequencing in Cancer Cells.
  Analysis of DNA co-immunoprecipitated with proteins of interest has been foundational to our understanding of chromatin and its regulation. Despite the emergence of crosslink-free techniques such as CUT&RUN and CUT&TAG, Chromatin Immunoprecipitation fo…
  pubmed Bigelow Z, Nechaev S, Dhasarathy A 2026 置信度 0.82
• Quantitative Phenotyping of Ion Fluxes in Tip-Growing Cells Under Varying Growth Regimes: A Data Analysis Protocol.
  Tip-growing cells exhibit complex growth regimes in vitro, alternating between growing and non-growing intervals, oscillatory or more steady behavior. In Arabidopsis thaliana, pollen tube growth arrest is often accompanied by spiking behavior in intracellular …
  pubmed Portes MT, Damineli DSC, Feijó JA 2026 置信度 0.82
• Automated Measurements of Fluorescence in Spatially Defined Regions of Pollen Tubes.
  Pollen tubes are a widely used model for the extension and development of polarized cells. Their relatively standard shape simplifies automated identification and image analysis of subregions. The key is reliable identification of the cell plasma membrane and …
  pubmed Adler J, Parmryd I 2026 置信度 0.82
• Examine neural network models for protein sequencing based features prediction.
  Protein functions are essential for understanding life at the molecular level. High-throughput sequencing generates vast amounts of raw protein sequences, but only about 1 percent have been carefully annotated with their functions. The experimental research ne…
  pubmed Senapati B, Das R 2026 Aug 26 置信度 0.82
• A power-law tailed movement created by trajectory retracing.
  Tracing specific trajectories allows a walker to revisit previous locations. However, how such local memory-based rules influence large-scale movement patterns remains unclear. In this paper, we propose a single walker model that explores a two-dimensional lat…
  pubmed Sakiyama T 2026 Aug 25 置信度 0.82
• Predictive design of tissue-specific mammalian enhancers that function in the mouse embryo.
  Enhancers control tissue-specific gene expression across animals 1 . Although deep learning 2,3 has enabled enhancer prediction and design in mammalian cell lines and non-mammalian model organisms 4-10 (reviewed in a previous publication 11 ), it remains uncle…
  pubmed Chen S, Loubiere V, Hollingsworth EW, Murakami K 等 2026 Aug 25 置信度 0.82
• Origins and consequences of oncogenic 3D chromatin remodelling.
  The 3D structure of chromatin is altered in cancer. In healthy cells, the genome is folded into functional 3D structural elements, including chromosomes, chromatin compartments, domains and loops. Cancer-associated alterations can modify each of these structur…
  pubmed Franceschini GM, Georgakopoulou K, Ciriello G, Oricchio E 2026 Aug 25 置信度 0.82
• Two essential criteria for transcription factor footprint discovery using V-plot.
  A recent study reported sequence biases in transcription factor (TF) footprinting data, and expressed concern about the accuracy in TF footprint discovery using V-plot analysis. Here we define two graphical parameters of V-plot as important criteria to impleme…
  pubmed Zhang Q, Xu C 2026 Aug 25 置信度 0.82
• Explainable hybrid multi-branch CNN-ViT-GNN framework for robust hibiscus leaf disease classification.
  Early and reliable diagnosis of hibiscus leaf diseases is critical to protect horticultural yield. Yet, it remains challenging under real-time field conditions where uncontrolled lighting, clutter, and the non-contiguous nature of pathological symptoms blur di…
  pubmed Billah MM, Sagor S, Hossain S, Alahmadi TJ 等 2026 Jul 23 置信度 0.82
• A benchmark study of vision and pathology foundation models for computational pathology.
  To advance precision medicine in pathology, artificial intelligence (AI)-driven foundation models must generalize across diverse datasets, tissues, and clinical tasks. However, their comparative performance and generalizability in computational pathology remai…
  pubmed Bareja R, Carrillo-Perez F, Zheng Y, Pizurica M 等 2026 Jul 24 置信度 0.82
• DICER1-related tumour predisposition mutations increase 3p-miRNA function and HERVH activity.
  The DICER1 gene is mutated in cancer, including in DICER1-related tumour predisposition. Cancer-associated hotspot mutations have been reported in both catalytic domains of DICER and are predicted to disrupt miRNA biogenesis. To understand how these hotspot mu…
  pubmed Gordon K, Bellora N, Witteveldt J, Wojtus JK 等 2026 Jul 25 置信度 0.82
• Patient-partnered multiomics reveals the molecular architecture of angiosarcoma.
  Angiosarcoma is a poorly understood sarcoma due to its high heterogeneity and rarity. Here we show a comprehensive clinical and molecular analysis of a large cohort of 254 angiosarcoma patients through the patient-partnered Angiosarcoma Project. By integrating…
  pubmed Chu H, Hollyer M, Borden BA, Reilly CR 等 2026 Jul 24 置信度 0.82
• A fully integrated smart ring for daily biochemical monitoring.
  Biochemical analysis complements biophysical measurements by capturing the underlying molecular and metabolic changes that drive physiological health. Here, we introduce a compact, fully integrated smart ring capable of simultaneously monitoring multiple chemi…
  pubmed Saha T, Ding S, Qin S, Fishman H 等 2026 Jul 23 置信度 0.82
• Structure-based design of stable recombinant hepatitis C virus E1E2 heterodimers.
  Hepatitis C virus (HCV) affects 47 million people and causes 239,000 deaths annually, yet no vaccine is on the horizon. Generating a stable native-like mimic of the envelope complex E1E2, the only target for known neutralizing antibodies, is an important aim f…
  pubmed Capella-Pujol J, Mulder F, Cannac F, Peters S 等 2026 Jul 23 置信度 0.82
• Functional immune changes are conserved in COVID-19 and trauma patients receiving intensive care.
  Critical illness, including COVID-19 and trauma, induce immune dysregulation associated with morbidity and mortality. Direct comparison is crucial to identify shared pathobiological mechanisms to guide precision therapies. This prospective cohort study underto…
  pubmed Wood AJT, Albers GJ, Cornelissen W, Maiden JD 等 2026 Aug 25 置信度 0.82
• Rapid minigene workflow for functional reclassification of splicing variants in hereditary cancer diagnostics.
  Next-generation sequencing of cancer predisposition genes is routinely used in hereditary cancer diagnostics. However, a substantial fraction of detected variants remains clinically unresolved. Using a customised 77-gene panel, we analysed 2142 individuals and…
  pubmed Calandra N, Mereu E, Ogliara P, Casalis Cavalchini G 等 2026 Aug 25 置信度 0.82
• Challenges and opportunities in type III secretion system effector prediction.
  Type III secretion system effectors (T3SEs) are small bacterial proteins with big biological roles. They act as central molecular mediators of interactions between Gram-negative bacteria and eukaryotic hosts, spanning pathogenic, symbiotic and environmental co…
  pubmed Rosić I, Nikolić I 2026 Aug 26 置信度 0.82
• Tunable asymmetric swimming in biflagellate microswimmers.
  Many biological microswimmers can modulate their swimming gait to achieve directional control of motility, especially when performing steering towards specific directional cues. This can be achieved without the need for obvious morphological or structural asym…
  pubmed Walker BJ, Moreau C, Robinson TL, Xu ZJ 等 2026 Aug 26 置信度 0.82
• Investigating the effectiveness of multimodal data in forecasting SARS-COV-2 case surges.
  The COVID-19 pandemic response relied heavily on statistical and machine learning models to predict key outcomes such as case prevalence and fatality rates. These predictions were instrumental in enabling timely public health interventions that helped break tr…
  pubmed Raghuvamsi PV, Loh SB, Bhattacharya P, Ho J 等 2026 Aug 25 置信度 0.82
• Characterization of aliA and aliB deletion mutants reveals a dominant role of AliA in Haloferax volcanii lipoprotein lipidation.
  Protein lipidation is a widespread strategy for anchoring proteins to cellular membranes across all domains of life, yet the mechanisms underlying this process in archaea remain poorly understood. Recently, the first archaeal enzymes involved in lipobox-contai…
  pubmed Hong Y, Garcia A, Kopelev S, Cote JA 等 2026 Aug 25 置信度 0.82
• Spanning-tree thermostatistics of protein allostery: An exact Kirchhoff framework with application to oncogenic KRAS.
  This study introduces a statistical mechanical framework for allosteric communication in proteins based on the spanning-tree ensemble of residue contact networks. By representing Cα protein backbones as weighted graphs, we identify each spanning tree as …
  pubmed Senguler Ciftci F, Erman B 2026 Aug 25 置信度 0.82
• Evaluating the impact of antiviral post-exposure prophylaxis for health-care workers during orthoebolavirus outbreaks: a modelling study.
  Orthoebolavirus outbreaks place health-care workers (HCWs) at substantial risk, and HCW illness or death can weaken response capacity. The 2026 Bundibugyo virus outbreak in DR Congo highlights the need for deployable countermeasures when species-specific vacci…
  pubmed Stapley JN, Ko Y, Jeyapragasan G, Chan EMG 等 2026 Aug 25 置信度 0.82
• Evaluation of the physical and radiological properties of different Fricke gel formulations as water-equivalent materials and biological tissues.
  Fricke gel dosimeters, also known as hydrogels, have emerged as attractive tools in clinical dosimetry due to the requirements of quality assurance protocols and radiation protection programs. The performance of these materials strongly depends on the characte…
  pubmed Dos Santos AMM, Araújo LF, Costa L, Araujo N 等 2026 Aug 25 置信度 0.82
• Spatial profiling of the spleen in mouse and human myelofibrosis reveals complement-driven immune-stromal interactions as a therapeutic target.
  Splenomegaly is a defining feature of myelofibrosis, yet the contribution of splenic mesenchymal stroma to disease progression remains unclear. We combined spatial and single-nucleus transcriptomics of patient spleens with spatial and single-cell transcriptomi…
  pubmed Dugué B, Wanner P, Ruiz Tejada Segura ML, Saad M 等 2026 Aug 25 置信度 0.82
• 16α-Hydroxydehydrotrametenolic acid attenuates MDA-MB-231 triple-negative breast cancer xenograft growth and modulates integrin β1/c-Met signaling and glycolytic metabolism.
  Abnormal glycolysis, enhanced metastatic potential, and dysregulated oncogenic signaling, including integrin β1 and c-Met pathways, are key drivers of triple-negative breast cancer (TNBC) progression and contribute to its poor prognosis and limited thera…
  pubmed Wu N, Luo Y, Quan Q, Huang X 等 2026 Aug 19 置信度 0.82
• Purine-centred fused, conformationally constrained, and ring-expanded analogues in antitumor and antiviral drug discovery: A comprehensive review.
  Purine-derived scaffolds remain important in anticancer and antiviral drug discovery because their electronic properties, hydrogen-bonding capacity, and conformational adaptability support interactions with kinases, polymerases, nucleotide-processing enzymes, …
  pubmed Nidhar M, Alam P, Alqarni MH, Foudah AI 等 2026 Aug 21 置信度 0.82
• Multidimensional interactions of living materials with biological entities.
  Living materials, defined by dynamic biological activity and responsive capabilities, are emerging as pivotal therapeutic agents in biomedicine. Their therapeutic effects are driven by active interactions with biological entities at multiple levels. However, m…
  pubmed Du S, Liu Y, Liu Y, Tan Y 等 2026 Aug 20 置信度 0.82
• Logic-gated nanoregulators: A paradigm shift from drug delivery to pre-programmed multi-target immunotherapy.
  Cancer immunotherapy has reshaped oncology, yet its broad application is constrained by an immunosuppressive tumor microenvironment and the systemic toxicities of conventional treatments. This review traces the evolution of nanomedicine from a passive drug del…
  pubmed Wu Y, Tang F, Lee J, Liang Y 等 2026 Aug 17 置信度 0.82
• Longitudinal inference of hippocampal volume and morphometric hippocampal-cortical covariance in psychosis.
  Schizophrenia and related psychoses are characterized by reductions in hippocampal volume and morphometric hippocampal-cortical covariance. No study to date has inferred the temporal relationship between deviations in subfield and adjacent white matter volume …
  pubmed Totzek JF, Heckers S, Palaniyappan L, Young AL 等 2026 Aug 6 置信度 0.82
• Physical and mental health among seasonal migrant farmworkers: Evidence from a survey conducted in northwestern Italy.
  Farmworkers exhibit a higher prevalence of musculoskeletal disorders, levels of anxiety, depression, and work-related stress compared with general population. However, few studies have investigated the main predictors of these outcomes. Therefore, this study a…
  pubmed Sodano B, Catalano A, Avanzi S, Gebru KT 等 2026 Aug 25 置信度 0.82
• Trace element-based Co(II) and Fe(III) mixed-ligand complexes of phenanthroline and sulfasalazine: Structural, DFT, molecular docking, and antimicrobial studies.
  New mixed ligand compounds FeSUPT and CoSUPT were successfully prepared using sulfasalazine (SU) and phenanthroline (PT). The compounds were recovered as solid, non-electrolyte substances with good thermal stability (above 300°C) and low molar conductivit…
  pubmed Khalaf MM, Abd El-Lateef HM, Eltayeb H, Abdou A 2026 Aug 20 置信度 0.82
• Can 18F-FDG PET/CT SUV(max) values predict breast and axillary pathological complete response before neoadjuvant chemotherapy in breast cancer?
  We aimed to investigate whether maximum standardized uptake value (SUV max ) values of breast mass and axilla metastatic lymph nodes are effective independent predictive factors for breast and axillary pathological complete response (PCR) before neoadjuvant ch…
  pubmed Koca B, Yildirim M, Saglam AI, Ozsoy U 2026 置信度 0.82
• Metabolomics of Eryngium heterophyllum by UHPLC-QToF-MS and In Silico Insights Into Potential Metabolic Syndrome Targets.
  Eryngium heterophyllum (toad grass) is native to Mexico and has been used traditionally to manage diabetes, hypercholesterolemia, and arthritis. However, its bioactive compounds remain poorly characterized. This study profiled the phytochemical composition of …
  pubmed Gutiérrez-Rodelo C, Galván LEM, Estrada-Lugo E, Avula B 等 2026 Aug 置信度 0.82
• Identification of candidate macrophage-ferroptosis crosstalk genes associated with immune infiltration in myocardial infarction: A bioinformatics analysis.
  Globally, myocardial infarction (MI) remains a major cause of morbidity and mortality. Macrophage-mediated inflammation and ferroptosis-related stress responses have both been implicated in MI; however, transcriptomic identification of macrophage- and ferropto…
  pubmed Wang G, Zhang Z, Yang G, Wang J 等 2026 置信度 0.82
• High reelin expression may explain why a subgroup of entorhinal cortex neurons functions as an initial nucleation site of Alzheimer's disease.
  The entorhinal cortex (EC) plays a crucial role in memory functions. Long before the clinical symptoms of Alzheimer's disease (AD) emerge, it has already undergone significant degeneration, making it a primary site for the onset of the disease. The reasons for…
  pubmed Kobro-Flatmoen A, Hussan JR, Hunter PJ, Omholt SW 2026 Aug 置信度 0.82
• Theory and evidence of amplitude control by frequency detuning in a coupled neuronal oscillator system.
  Neuronal oscillator circuits that generate rhythmic movements must operate flexibly and reliably to produce the varied motor patterns that animals exhibit naturally. Rodents rhythmically "whisk" their vibrissae for haptic perception, and they dynamically adjus…
  pubmed Lu AC, Ourang SA, Moore JD 2026 Aug 25 置信度 0.82
• A unified CPG-based and multi-agent control framework for low-cost quadruped robots.
  Quadruped robots have gained significant attention due to their superior mobility on uneven and unstructured terrains, offering potential applications in inspection, search and rescue, and field exploration. However, achieving robust locomotion on low-cost pla…
  pubmed Wu L, Zhang M, Wang W 2026 置信度 0.82
• The multi-omics fallacy in microbiome science.
  Artificial intelligence and machine-learning-assisted multi-omics have expanded the scale and ambition of microbiome research, but they have also sharpened an older interpretive problem. Biologically plausible structure is too easily mistaken for biological ex…
  pubmed Lewandowski R 2026 Aug 置信度 0.82
• A decade of artificial intelligence research in ophthalmology: Global trends and transferable insights for medical AI.
  To characterize global trends in ophthalmic AI research from 2015-2025 and drive transferable insights into the broader evolution of AI in medicine, we conducted a systematic bibliometric analysis of original AI articles in ophthalmology indexed in the Web of …
  pubmed Fan Z, Qin Y, Chen L, Yuan J 等 2026 Aug 置信度 0.82
• Community-driven updates for comprehensive long-read metagenomics and enhanced binning in nf-core/mag v5.
  nf-core/mag is a reproducible Nextflow pipeline for best-practice metagenomic de novo assembly, and binning within the nf-core framework. Here we present a major update that adds support for long-read-only assembly and bin refinement, includes five new binning…
  pubmed Alvarez Saravia D, Rosenbaum A, Straub D, Downie J 等 2026 Aug 25 置信度 0.82
• Morphing active networks.
  Biological networks like leaf venation exhibit remarkable morphing capabilities that enable organisms to adapt and thrive in their environments. However, the underlying mechanisms that govern the morphing of such networks, especially when the network itself ac…
  pubmed Wen Y, Chen Y, Yang Y, Xu F 2026 Sep 置信度 0.82
• Overview of exosomal non-coding RNAs in cardiovascular disease using high throughput sequencing.
  Non-coding RNAs including miRNAs, long-ncRNAs, and circular RNAs play crucial roles in cell-to-cell communication and epigenetic regulation. They control gene expression at multiple levels, including transcriptional, post-transcriptional, and translational, th…
  pubmed Eivazi M, Abkhooie L, Hosseini K, Mobasheran P 等 2025 Nov 15 置信度 0.82
• Single-Cell Glycomics of the Pancreatic Tumor Microenvironment: Technologies, Glyco-Immune Checkpoints, and Tumor-Immune Communication.
  In this Review, we summarize recent conceptual and technological advances in single-cell glycomics, with a particular focus on emerging strategies that enable glycan-resolved analysis of tumor-immune interactions. We highlight single-cell glycan and RNA sequen…
  pubmed Anh DXT, Tateno H 2026 Aug 置信度 0.82
• RGCNMDA: Pathway-Bridged Relational Graph Learning with Adaptive Multi-View Fusion for Human miRNA-Disease Association Prediction.
  MicroRNAs are key post-transcriptional regulators whose dysregulation is associated with complex human diseases. Computational prediction can prioritize candidate miRNA-disease associations, but reliable evaluation is complicated by sparse labels, cold-start e…
  pubmed Hou C, Kone M, Xiang Y, Wang S 2026 Aug 25 置信度 0.82
• Bioinformatic identification of THY1 as a target in osteoarthritis and its effects on chondrocyte senescence and apoptosis.
  Osteoarthritis (OA) is the most prevalent degenerative joint disease worldwide and imposes a substantial public health burden due to the lack of effective disease-modifying drugs. Exosome-related genes participate in exosome biogenesis, cargo sorting, and secr…
  pubmed Huang L, Wen Y, Xu H, Zhang Z 等 2026 Aug 25 置信度 0.82
• Gene Genealogies in Haploid Populations Evolving According to Sweepstakes Reproduction.
  Recruitment dynamics, or the distribution of the number of offspring among individuals, is fundamental to ecology and evolution. We take sweepstakes reproduction to mean a skewed (heavy right-tailed) offspring number distribution without natural selection bein…
  pubmed Eldon B 2026 Aug 25 置信度 0.82
• TIMSImaging: An open and interoperable workflow for trapped ion mobility mass spectrometry imaging data processing and visualization.
  Mass spectrometry imaging (MSI) enables high-throughput spatial mapping of molecules, but the lack of chromatographic separation limits its utility for complex biological samples. Ion mobility (IM) provides key orthogonal separation. However, open-source tools…
  pubmed Zhu Y, Bemis K, Lakkimsetty SS, Li MJ 等 2026 Aug 25 置信度 0.82
• A multivariate toolkit for joint articulatory-acoustic analysis with an application to coarticulation.
  This study presents an integrated methodology for analyzing the effects of coarticulation on both articulatory and acoustic properties of phoneme sequences. The approach combines co-registered real-time magnetic resonance imaging (MRI) and acoustic recordings,…
  pubmed Danner T, Moran S, Friedrichs D, Ponce de León MS 等 2026 Aug 1 置信度 0.82
• Structural and functional insights into Pseudomonas aeruginosa ApaH, a diadenosine tetraphosphatase crucial for bacterial virulence.
  Infections by Pseudomonas aeruginosa are a major cause of severe morbidity and mortality in immunocompromised patients and people with cystic fibrosis, largely due to the pathogen's ability to resist antibiotic treatment and to deploy multiple virulence strate…
  pubmed Pistoia G, Cervoni M, Catalano F, Troilo F 等 2026 Sep 置信度 0.82
• Tissue-Agnostic Cellular Morphometric Biomarkers for Risk-Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers.
  While precision oncology increasingly adopts tissue-agnostic paradigms, current strategies remain heavily reliant on molecular alterations, with limited relevance to early-stage cancers and precancerous lesion management. Here we present an unsupervised and in…
  pubmed Wang P, Jiang C, Mao AW, Sun Q 等 2026 Aug 25 置信度 0.82
• Enhanced Immunogenicity and Cross-Neutralizing Activity of a Trivalent Adenoviral Vector-Based SARS-CoV-2 Vaccine in Mice.
  The emergence of diverse SARS-CoV-2 Omicron subvariants has reduced the efficacy of existing vaccines, highlighting the need for multivalent vaccines with broader neutralizing capacity. We developed a trivalent adenoviral vector-based vaccine (Ad5-CoV19-protot…
  pubmed Li J, Song W, Li J, Peng R 等 2026 Aug 置信度 0.82
• Improving annotation, access, and comparison of nutritional composition data for underutilized crops.
  Open and interoperable data infrastructures are essential to advancing food and nutritional security research, yet few data management systems are specifically designed for crop nutritional datasets that support seamless querying, visualization, and comparison…
  pubmed Aboagye A, Shaw PD, Raubach S, Mayes S 等 2026 Jan 15 置信度 0.82
• Regulatory effects and mechanisms of the acupuncture-induced complement component 1q on the high mobility group box 1 -receptor for advanced glycation end products-nuclear factor kappa-B pathway at Zusanli (ST36).
  To investigate what are the crucial regulators and mechanisms involved in regulating the inflammatory responses at Zusanli (ST36).
  pubmed Xiaochun K, Sinuo WU, Ningcen LI, Wenyue XU 等 2026 Aug 置信度 0.82
• Dynamic Predictions and Predictimands for Salvage Therapy in Recurrent Prostate Cancer Using Joint Models.
  Prostate cancer patients with biochemical recurrence (BCR) face a decision of whether to start salvage therapy (ST), which may reduce the probability of metastatic progression at the cost of side effects. To inform the decision to start ST at or after BCR, mod…
  pubmed Owens L, Rizopoulos D, Fainberg J, Carlsson S 等 2026 Sep 置信度 0.82
• Effect of Consecutive Jumping Trials on Metatarsophalangeal, Ankle, Knee and Hip Biomechanics During Take-Off and Landing: A Replication and Extension Study.
  Replication is a fundamental aspect of scientific research, but few replications have been conducted within sports biomechanics yet. The aim of this study was to closely replicate Lam et al. (2021) study, investigating the differences of single and consec…
  pubmed Duchene Y, Hanen NC, Murphy J, Banet L 等 2026 Sep 置信度 0.82
• SeizureBiomeDB: a unified database of gut microbiome alterations in pediatric and adult epilepsy.
  The gut microbiome plays a critical role in health, immunity, metabolism, and brain function. Growing evidence links it to neurological health via the gut-brain axis. Seizure disorders are associated with distinct microbial changes that vary by epilepsy type a…
  pubmed Walji Z, Dave P, Ali M, Negmeldin O 等 2026 置信度 0.82
• Probiotics in Human Health: Current Evidence, Mechanism of Action, and Future Perspectives.
  Probiotics are widely recognized for their potential to promote human health through diverse mechanisms that influence host physiology and microbial ecology. This review synthesizes current evidence on the biological functions, mechanisms of action, and therap…
  pubmed Mulaw G, Kidanemariam G, Bara M, Tesfay T 2026 置信度 0.82
• Transcriptional Profiling of Growth Hormone-Secreting Pituitary Adenoma Stem-Like Cells: Unveiling the Significant Role of CXCR4 in Tumorigenesis and Clinical Applications.
  Growth hormone-secreting pituitary adenoma (GHPA) can cause excessive growth hormone production, which can lead to clinical symptoms such as acromegaly. Tumor stem cells (TSCs) are postulated to play a significant role in the development of GHPA. We performed …
  pubmed Yuan L, Yang H, Li B, Sui H 等 2026 Sep 置信度 0.82
• Microbiome-Driven Risk Stratification and Biotherapeutics in Radiation Enteritis.
  Radiation enteritis (RE) is a severe, dose-limiting complication of cancer radiotherapy that affects the therapeutic outcomes of patients and their quality of life. Current risk assessments primarily rely on physical dosimetry. However, this approach inherentl…
  pubmed Wang Z, Chai Y, Lin T, Zhang Q 等 2026 置信度 0.82
• MRI-Based Deep Learning Guides Multi-Omics Discovery of NBPF4 as a Therapeutic Target for Breast Cancer Lymph Node Metastasis.
  Deep learning models are increasingly used to analyze medical images, but their "black box" nature makes it hard to understand the underlying biology and slows down the development of targeted treatments. To tackle this, we built a multi-step approach that com…
  pubmed Cai D, Huang H, Chen Z, Zhu C 等 2026 置信度 0.82
• Multi-omics analysis of histidine metabolism reveals FRZB-CRYM-associated cellular crosstalk in heart failure.
  The role of histidine metabolism in heart failure (HF), particularly its heterogeneous regulation across cardiac cell types, remains unclear. This study aims to define its mechanistic basis and identify key regulatory genes.
  pubmed Xiao S, Mo C, Liu Q, Xu L 2026 置信度 0.82
• Iodine-mediated 2,5-di(aryl/heteroaryl)-1,3,4-oxadiazoles: synthesis, and in vitro and in silico studies of anticancer and antifungal properties.
  Recent studies have highlighted the 1,3,4-oxadiazole scaffold as an important pharmacophore present in numerous biologically active molecules and therapeutic agents. In continuation of our interest in biologically active heterocyclic compounds, we report the s…
  pubmed Ramesha T, Shenoy TN, Subba Reddy UV, Ega JK 等 2026 Aug 24 置信度 0.82
• Weighted epigenetic site correlation network analysis of chemotherapy impacts on osteosarcoma cancer survivors' male fertility, sperm, and endocrine parameters.
  The impacts of chemotherapy exposure on adolescent male osteosarcoma survivors as adults were investigated using a number of physiological parameters, with a focus on chemotherapy, reproduction, and sperm. The Children's Oncology Group (COG) clinical sites (pr…
  pubmed Shnorhavorian M, Amory JK, Schwartz SM, Bhatia S 等 2026 置信度 0.82
• LAFA: a framework for reproducible longitudinal assessment of protein function annotation models.
  Protein function prediction is a challenging task and an open problem in computational biology. The Critical Assessment of protein Function Annotation (CAFA) is a triennial, community-driven initiative that provides an independent, large-scale evaluation of co…
  pubmed Phan A, Wang Y, Boadu F, Cheng J 等 2026 置信度 0.82
• Artificial intelligence-assisted smart hydrogel bioinks in 3D bioprinting: design, optimization, and construct validation for functional tissue engineering.
  Hydrogel-based bioinks are central to three-dimensional (3D) bioprinting because they provide hydrated, cell-supportive microenvironments with tunable rheological, mechanical, and biological properties. Smart hydrogel bioinks further introduce stimuli-responsi…
  pubmed Zhang S, Liang D, Lei Y, Luo Y 等 2026 置信度 0.82
• Oral corticosteroid dosing strategies for post-COVID-19 organising pneumonia: NORCOVID clinical trial.
  Organising pneumonia is an interstitial lung disease linked to infections and other conditions. Cryptogenic organising pneumonia is a rarer, idiopathic form. Organising pneumonia has become one of the most frequent respiratory complications following severe ac…
  pubmed Espejo-Castellanos D, González-Amezcua A, Pilia MF, Ferreiro-Posse A 等 2026 Jul 置信度 0.82
• Self-identified African ancestry and pathomics-derived tumor-infiltrating lymphocyte scores in colon and rectal adenocarcinoma whole-slide images: an exploratory multicohort whole-slide image study.
  AI assisted computed higher tumor infiltrating lymphocyte% (TIL%) scores from hematoxylin and eosin (H&E) stained whole slide images (WSI) may serve as a useful biomarker for stratifying patients for treatment with immune checkpoint inhibitors.
  pubmed Zhang Y, Cheng X, Liao Y, Adams S 等 2026 置信度 0.82
• Decidua macrophages display a restrained inflammatory profile during chorioamnionitis.
  Decidual macrophages (DMs) are strategically located at the maternal-fetal interface to orchestrate innate host defense while balancing tolerance to the allogenic fetus. An important pregnancy complication is chorioamnionitis characterized by infection/inflamm…
  pubmed Pithia N, Musumarra CV, Protti G, Del Vecchio G 等 2026 置信度 0.82
• Molecular determinants of differential substrate selection between the Src family kinases Lck and Src.
  Src family kinases (SFKs) share highly conserved catalytic domains yet display distinct biological functions, raising the question of how substrate specificity is achieved. Here, we investigate the basis of differential ITAM recognition by Lck and Src, using c…
  pubmed Karpouzou K, D'Abramo M, Grottesi A, Acuto O 等 2026 置信度 0.82
• Combination treatment with intravesical interferon-alpha gene therapy and an oral pan-ErbB receptor family blocker improves survival in mice with bladder cancer.
  Intravesical interferon-alpha (IFNα) gene therapy is approved by the FDA for BCG-unresponsive non-muscle invasive bladder cancer (NMIBC). Identifying resistance mechanisms and deploying targeted combination treatment strategies is a rational approach to …
  pubmed Sood A, Martini A, Genitiano P, Rauf M 等 2026 置信度 0.82
• Pre-expansion downward maxillary base rotation as a biomarker for post-expansion downward maxillary rotation in adults treated with 3D-guided midpalatal piezocorticotomy-assisted MARPE: a pilot case-control study.
  Structural predictors of success or failure in adult maxillary expansion remain poorly defined. This retrospective case-control pilot study aimed to evaluate the predictive capacity of pre-treatment craniofacial morphology-specifically the palatal plane inclin…
  pubmed Koval S, Chepanova D, Stepanoff N, Babii A 等 2026 置信度 0.82
• Brainstem Theory of Consciousness.
  The brainstem theory of consciousness asserts that raw, subjective experience, the "me inside," derives from computations implemented in the brainstem, not the cortex. The argument rests on philosophy's prototypical example of sentience, pain. Feeling pain doe…
  pubmed Devor M, Baron M 2026 Aug 25 置信度 0.82
• AI-powered medicinal chemistry and translational drug development.
  Medicinal chemistry sits at the center of modern drug discovery, yet translating molecular designs into approved medicines remains slow, expensive, and prone to high attrition across the pipeline from target identification to clinical validation. Artificial in…
  pubmed U K, Zhang SM, Yu Z, Zhang Z 等 2026 Aug 25 置信度 0.82
• Targeting the ERK2 Signaling Pathway With Frog Skin-Derived Bioactive Peptides: Insights From Molecular Modeling, Molecular Dynamics, and Physicochemical Features.
  ERK2 plays a vital function in promoting cell survival and proliferation by phosphorylating various substrates. ERK2 is a key druggable target owing to its function in uncontrolled cell proliferation and cancer, making selective ERK2 inhibitors essential for t…
  pubmed Almansour NM, Abdelhamid MMH, Alali Z, Ibrahim MAA 2026 Sep 置信度 0.82
• Practically Error-Free Junctions Enable Solving Large Instances of Exact Cover Problems Using Network-Based Biocomputation.
  Network-based biocomputing (NBC) presents an energy-efficient, parallel computing approach for solving nondeterministic polynomial time (NP) complete problems by leveraging motor-driven cytoskeletal filaments that explore all possible solutions through nanofab…
  pubmed V R EC, Meinecke CR, Nitzsche B, Lyttleton R 等 2026 Aug 24 置信度 0.82
• Association of Combined MET/HGF Expression With the Colorectal Cancer Immune Microenvironment: An Integrated Immunohistochemical and Multi-Database Analysis.
  To validate c-MET protein expression in colorectal cancer (CRC) and assess whether joint MET and hepatocyte growth factor (HGF) transcript expression provides descriptive information on tumor microenvironment features beyond MET alone.
  pubmed Luo S, Guo H, Li X, Long Y 等 2026 Aug 置信度 0.82
• Constant-pH molecular dynamics simulations of closed and open states of a proton-gated ion channel.
  Although traditional molecular dynamics simulations successfully capture a variety of different molecular interactions, the protonation states of titratable residues are kept static. A recent constant-pH molecular dynamics implementation in the GROMACS package…
  pubmed Jansen A, Bauer P, Howard RJ, Hess B 等 2026 Aug 24 置信度 0.82
• Prevalence and Determinants of Anemia among Adolescent Girls in Rural Nepal.
  Adolescence is a period of rapid growth and increased nutritional requirements, making girls in low- and middle-income countries, such as Nepal, vulnerable to iron deficiency anemia. In rural areas of Nepal, menstrual blood loss, poor diet, and socio-cult…
  pubmed Bhandari TR, Chapagain N, Paudel S, Nagila A 等 2026 Aug 3 置信度 0.82
• Rpf-Toxo: A Preliminary Computationally Designed Dense Granule Antigen-Based Multi-Epitope Vaccine Against Toxoplasma gondii.
  Toxoplasma gondii is a protozoan parasite of medical and veterinary importance causing abortion. While current therapies are limited to address the chronic phase of infection, effective prophylactic vaccines are warranted.
  pubmed Safari MH, Hosseini SA, Ghiabi S, Ghiabi S 等 2026 Sep 置信度 0.82
• A Cytochrome P450 Enzyme-Catalyzed Acetyl Migration in Cyanogramide Biosynthesis.
  Cyanogramide (1) is a unique spirooxindole alkaloid derived from a marine actinomycete and is characterized by its distinct spirocyclic pyrrolo[1,2-c]imidazolidin-4-one scaffold. Although we have successfully elucidated the biosynthetic pathway of 1, the mecha…
  pubmed Zhu Y, Wang Y, Zhang L, Fang C 等 2026 Aug 24 置信度 0.82
• Brain-computer interface for upper limb functional recovery post-stroke: a meta-analysis of improvement in upper limb motor function and changes in neurophysiological markers.
  Brain-Computer Interface (BCI) has emerged as a promising intervention, facilitating recovery of upper limb motor function, enhancing associated neurophysiological markers, and improving activities of daily living (ADL) performance, which is measured using the…
  pubmed Zhang H, Xian R, Zhang Y, Liu X 等 2026 Aug 24 置信度 0.82
• Assessment of livestock depredation by hamadryas baboons (Papio hamadryas) in and around Borena-Sayint National Park, northern Ethiopia.
  As human populations expand and natural habitats become increasingly fragmented, the interface between agricultural activities and wilderness areas has become a focal point of ecological tension. Livestock depredation is a prevalent form of human-wildlife conf…
  pubmed Ibrahim H, Bekele A, Yazezew D, Moges A 等 2026 Aug 13 置信度 0.82
• Computational applications in secondary metabolite discovery (CAiSMD) 2026: focus on secondary metabolites towards drug discovery.
  The Computational Applications in Secondary Metabolite Discovery (CAiSMD) 2026 workshop was held from 24 to 26 March 2026 in a hybrid format, combining onsite participation at the University of Buea Center for Drug Discovery with global virtual attendance. Bui…
  pubmed Ntie-Kang F, Betow JY, Eni DB, Metuge JA 等 2026 Aug 24 置信度 0.82
• Pluripotency, differentiation, and reprogramming: 20 years of induced pluripotent stem cells.
  pubmed Hainer SJ, Strawbridge SE, Choi S, Guo G 等 2026 Aug 25 置信度 0.82
• [Teaching reform and practice of a project-based graduate course Bioinformatics in the era of artificial intelligence].
  The rapid development of big data and artificial intelligence (AI) necessitates highly skilled and innovative talents in bioinformatics and the change of conventional teaching for postgraduates. In this study, we identified key challenges in the current teachi…
  pubmed Liao Y, Jiang H, Xu H, He Y 等 2026 Aug 25 置信度 0.82
• [Experimental and computational analyses of altered cetuximab binding induced by EGFR mutations].
  Acquired mutations in the extracellular domain of epidermal growth factor receptor (EGFR) are major causes of cetuximab resistance. However, the structural mechanisms by which different mutations impair antibody binding remain to be clarified. In this study, f…
  pubmed Li Y, Yang H, Zhu J, Wu M 2026 Aug 25 置信度 0.82
• [Rational design and translational applications of hepatitis B virus-like particles].
  Hepatitis B virus-like particles (HBV-VLPs), characterized by precise biomimetic topological architecture and favorable biocompatibility, have become a highly promising cutting-edge carrier in nanomedicine and immune engineering. This article systematically su…
  pubmed Yang Z, Zheng J, DU X, Guan L 等 2026 Aug 25 置信度 0.82
• Standardized Workflow for Long Noncoding RNA Prediction and Expression Profiling in Wheat Under Stem Rust Stress.
  Long noncoding RNAs (lncRNAs), typically over 200 nucleotides in length, with low or no coding capacity, possess significant regulatory roles in plant growth, development, and stress responses by interacting with DNAs, proteins, and other RNAs. This chapter ou…
  pubmed Jyothsna S, Alagu M 2026 置信度 0.82
• FASTA-Fetcher: A Multicolumn Tool for Bulk Retrieval of NCBI Sequences in Plant-Biotic Stress Research.
  Timely and accurate detection of plant pathogens is critical for sustainable agriculture and forestry. Molecular methods enable unequivocal pathogen identification, especially when traditional diagnostics fall short, allowing timely and effective interventions…
  pubmed Ramkrishna, Negi N, Pandey S 2026 置信度 0.82
• An Integrated Computational Method for Investigation of Structural and Functional Impacts of Host-Pathogen Interaction.
  Understanding the mechanisms underlying disease requires detailed insight into host-pathogen interactions. This study presents an integrated computational framework that combines structural bioinformatics and systems biology to analyze the structural and funct…
  pubmed Sahu S, Rashmi M, Sharma S, Sachdeva N 等 2026 置信度 0.82
• Beyond benchmarking: an expert-guided consensus approach to spatially aware clustering.
  Spatial omics technologies have revolutionized the study of tissue architecture and cellular heterogeneity by integrating molecular profiles with spatial localization. In spatially resolved transcriptomics, delineating higher-order anatomical structures is cri…
  pubmed Sun J, Biharie K, Cai P, Müller-Bötticher N 等 2026 Aug 24 置信度 0.82
• Measuring surprisal in sound sequences.
  Sensory input that violates prior expectations attracts attention, making unpredictability an important perceptual property to measure. In the auditory modality, knowing what sounds will be perceived as surprising, and therefore salient, is relevant both for s…
  pubmed Anikin A 2026 Aug 24 置信度 0.82
• Beyond the flat screen: evaluating virtual reality as a complementary tool for molecular docking in drug discovery.
  Molecular docking is a key computational approach in drug discovery and structural biology. Traditional docking tools, while effective for high-throughput screening, often rely on rigid or semiflexible receptor models and purely algorithmic sampling, limiting …
  pubmed Feoktistova VA, Aruko K, Skorb EV, Shityakov S 2026 Aug 24 置信度 0.82
• Outcomes of restorative proctectomy and ileal pouch-anal anastomosis: a matched-cohort analysis of robot-assisted, laparoscopic, and open surgery.
  Ileal pouch-anal anastomosis (IPAA) remains the gold standard for restorative proctocolectomy, yet its technical complexity has limited widespread minimally invasive adoption. Robotic surgery was introduced to overcome the ergonomic and visualization challenge…
  pubmed Violante T, Cardelli S, Romano A, Tiano A 等 2026 Aug 24 置信度 0.82
• Motor neurons organize Drosophila feeding sequences via a disinhibitory cascade.
  Classical models view motor neurons as the final relays of commands driving behaviors such as breathing and feeding. Here, in simultaneous quadruple-electrode recordings from Drosophila performing feeding behavior, we demonstrate that the relevant motor neuron…
  pubmed Sui XW, Yi JJ, Zhou Y, Wang YL 等 2026 Aug 24 置信度 0.82
• Obligate cross-feeding of metabolites is common in soil microbial communities.
  Ecological theory predicts that obligate cross-feeding of metabolites is common in microbial communities. However, systematic studies testing this prediction in natural microbial communities such as soil are missing, thus hindering the understanding of these e…
  pubmed Yousif G, Zorrilla F, Dash S, Oña L 等 2026 Sep 置信度 0.82
• High-throughput in silico multi-epitope reverse vaccine design against hydatidosis.
  The Middle East is a significant hotspot for human hydatidosis caused by Echinococcus granulosus, a complex multi-stage pathogen exhibiting antigenic variation with diverse epitopes. Multi-epitope vaccines, designed using immunoinformatics, represent a promisi…
  pubmed Skhal D, Al Nahhas S, Skhal O, Abbady AQ 2026 Aug 11 置信度 0.82
• PotatoRTD and TomatoRTD: Comprehensive Reference Transcript Datasets for Accurate Transcriptome Analysis and Isoform Discovery.
  Transcriptome annotations provide essential information on transcript locations, sequences and structures, including transcription start, end sites and splice junctions. They underpin key biological analyses such as gene and transcript quantification, and the …
  pubmed Guo W, Milne L, Lopez-Gomollon S, Kaur A 等 2026 Aug 24 置信度 0.82
• Enabling molecular signaling with temperature and ionic-strength independence or programmable dependence.
  The equilibrium constants of chemical reactions fundamentally depend on temperature, posing challenges for living systems. However, many conformer organisms do not maintain a stable internal temperature. This raises the question: can molecular signaling pathwa…
  pubmed Korenkov ES, Nikitin MP 2026 Aug 7 置信度 0.82
• Inhibition of cyclin-dependent kinase 8 modulates chondrocyte transition to hypertrophy and provides in vivo protection against spontaneous osteoarthritis.
  Chondrocyte hypertrophy is a key hallmark of osteoarthritis (OA) that drives a multitude of whole-joint disease processes. There are no approved disease-modifying pharmaceuticals in clinical use, emphasising the urgent need for innovative therapeutics. Screeni…
  pubmed Wells LM, Keen JAC, Sharma A, Marr N 等 2026 Aug 25 置信度 0.82
• Computational exploration of phycobiliproteins-derived peptides: in-silico gastrointestinal digestion and multi-target molecular docking against Alzheimer's disease-related enzymes.
  Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by amyloid-β (Aβ) accumulation, Tau hyperphosphorylation, and cholinergic dysfunction, necessitating multi-target therapeutic strategies. This study evaluated phy…
  pubmed Lijassi I, Mansouri Z, Rhazi L, Wahby I 2026 Aug 24 置信度 0.82
• Complex enzymolysis-derived peanut peptides: in silico selection of antioxidant peptides, emulsion-microcapsule encapsulation, and in vitro digestive performance evaluation.
  Peanut peptides (PP) are promising plant-derived functional ingredients, but bitterness and gastrointestinal instability limit oral applications. This study integrated complex enzymolysis, LC-MS/MS-assisted in silico screening, molecular dynamics (MD), and W 1…
  pubmed Jia C, Wang Y, Ran T, Gong Z 等 2026 Oct 31 置信度 0.82
• Advancements in the research of antioxidant peptides: A comprehensive overview.
  Oxidative stress can trigger apoptosis, tissue damage, and the onset of various chronic diseases. By maintaining cellular homeostasis, antioxidants can effectively reduce the risk of diseases associated with oxidative damage, including cardiovascular diseases,…
  pubmed Bai X, Pan W, Xu M, Rafiq M 等 2026 Oct 31 置信度 0.82
• Machine learning-assisted spectroscopic approaches for pesticide residue detection in food matrices.
  The widespread use of pesticides in modern agriculture has substantially improved food production while raising serious concerns regarding contamination and food safety. Considerable scientific effort has focused on improving methods for monitoring and detecti…
  pubmed Ezenwanne BC, Okoye CO, Abhadiomhen SE, Aham EC 等 2026 Oct 31 置信度 0.82
• Evaluating the potential of foodborne chemicals to modulate intestinal barrier function: a combined in vitro/in silico toolbox to study the effects on tight junction protein claudin-4.
  Intestinal barrier integrity is of paramount importance for our health. Several food constituents and contaminants have been described for positive or detrimental effects, however, a correlation between gut associated disorders and xenobiotics exposures remain…
  pubmed Bergen J, Fellinger C, Weinstabl M, Jobst M 等 2026 Oct 31 置信度 0.82
• Theory-driven computational psychiatry and its challenges: An optimistic outlook.
  Mental health disorders affect millions worldwide, yet our understanding of their underlying mechanisms remains limited, impeding the development of precise and effective treatments. Computational psychiatry, a burgeoning field at the intersection of neuroscie…
  pubmed Fisher EL, Sajid N, Convertino L, Hohwy J 2026 Aug 27 置信度 0.82
• Topographic gradients of resting-state EEG alpha asymmetry: Network-specific lateralization and age-related dedifferentiation in healthy adults.
  Alpha asymmetry, which quantifies hemispheric differences in alpha power (8-13 Hz), serves as a neurophysiological marker of cortical activation. While frontal alpha asymmetry has been extensively studied in affective disorders, full topographic character…
  pubmed Caravaglios G, Caravaglios L, Vestini MA, Di Maria G 等 2026 Aug 24 置信度 0.82
• Living drug carriers: Microbial and bioengineered platforms redefining precision therapeutic and immunomodulatory delivery.
  Microbial living therapeutics are a new class of drug-delivery materials that combine synthetic biology, immunomodulation, and advanced formulations to achieve controllable therapeutic effects in space and time. In the broad field of living drug-delivery syste…
  pubmed Guha L, Malik JA, Bose B 2026 Aug 24 置信度 0.82
• An inherited hypomorphic variant in PIEZO2 reveals structural features of mechanotransduction.
  PIEZO2 is the principal mechanosensory channel for proprioception, touch, and many interoceptive processes, yet key details of how PIEZO channels convert force into electrochemical signals remain unclear. Here, we report fraternal twins with proprioceptive ata…
  pubmed Nickolls AR, Mulhall EM, Orlin DJ, Yarishkin O 等 2026 Aug 24 置信度 0.82
• Explainable spatio-temporal transformers for schizophrenia classification and activity analysis from functional MRI.
  Schizophrenia is a complicated neuropsychiatric disorder caused by disturbed brain connectivity and abnormal neural activation patterns. To identify these underlying neural mechanisms, computational models need to be reliable and interpretable to support objec…
  pubmed Sarveswaran T, Rajangam V 2026 Aug 20 置信度 0.82
• New insights into multi-endpoint toxicological profiles and potential molecular mechanisms for display-related organic light-emitting/modulating materials.
  Display-related organic light-emitting/modulating materials (DOLMs) are increasingly detected in the environment, raising growing health concerns. However, toxicological data remain available for only a limited number of DOLMs, and their toxicity and underlyin…
  pubmed Tang M, Wu W, Wang Y, Liu X 等 2026 Aug 24 置信度 0.82
• Bacterial dehalogenases for organohalide and organofluorine remediation: Mechanistic insights, evidence gaps, and future relevance to GenX treatment.
  Bacterial dehalogenase enzymes catalyze the cleavage of carbon-halogen bonds and play important roles in the microbial transformation of many halogenated contaminants. This review critically examines major classes of bacterial dehalogenases, including haloalka…
  pubmed Kontoh DB, Deng D, Fu H, Lamssalli M 2026 Aug 24 置信度 0.82
• Omitting Bone Marrow Sampling in FDG-Avid Rhabdomyosarcoma With 2-[(18)F]FDG PET-Negative Marrow: Results From an International Retrospective Study.
  Detection of bone marrow disease has been a major component of rhabdomyosarcoma (RMS) staging with bilateral bone marrow aspirates/biopsies (BMAB) from the iliac crests considered the diagnostic gold standard. This study's goal was to determine if 2- 18 F-labe…
  pubmed Mercolini F, Just M, Shulkin BL, Collins NB 等 2026 Aug 24 置信度 0.82
• HLA class I escape drives the evolution of SARS-CoV-2 in human populations.
  The role of escape from the cytotoxic T cell (CTL) response in Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation…
  pubmed Riumina ED, Alekseeva EI, Klink GV, Feigin S 等 2026 Sep 置信度 0.82
• The role of chloride ions in serotonin transport.
  The human serotonin (5-HT + ) transporter SERT facilitates 5-HT + transport into cells by coupling it to Na + symport and K + antiport. Although extracellular Cl - is also essential for transport, Cl - cotransport has been disputed, raising questions about the…
  pubmed Huang J, Backer A, Uchendu S, Bekele B 等 2026 Sep 置信度 0.82
• Shifting gears to power human walking.
  The musculoskeletal system features an abundance of functionally similar muscles, yet the performance benefits of this apparent redundancy remain unclear. Here, we show that muscles with similar function, but distinct moment arms, facilitate a dynamic gear-shi…
  pubmed Martin JA, Welte L, Knurr KA, Thelen DG 2026 Sep 8 置信度 0.82
• Assessment of CD3+ T cell density in the intestinal mucosa of dogs with inflammatory bowel disease.
  T lymphocytes play a central role in the intestinal immune response in dogs with immunomodulator-responsive enteropathy (IRE), but the clinical relevance of mucosal T-cell infiltration remains unclear.
  pubmed Bouillet G, Méric T, Gonel G, Darnis E 等 2026 Jul 1 置信度 0.82
• Replication-transcription collisions impose DNA strand-specific constraints on gene length in bacteria.
  Gene length is a peculiar genomic feature that exhibits minimal variation within domains of life, suggesting universal underlying constraints. The length of a gene is primarily influenced by its function, expression level, and mutation risk. Interestingly, man…
  pubmed Variyar A, Patil S, Babu J, Bhat A 等 2026 Aug 置信度 0.82
• Exome-based cancer driver gene comprehensive testing can provide a genetic diagnosis for individuals with triple-negative breast cancer.
  Triple-negative breast cancer (TNBC) is characterized by aggressive behaviour, high tumor heterogeneity, and an increased likelihood of recurrence and early metastasis. These factors hinder successful treatment. Genetic diagnosis enables personalized clinical …
  pubmed Alzate D, Sánchez AY, Pacheco Y, Isaza Ruget M 等 2026 置信度 0.82
• Systematic analysis of global O-serotype prevalence of neonatal extraintestinal pathogenic Escherichia coli: A protocol integrating previous research and bioinformatics databases.
  Neonatal extraintestinal pathogenic Escherichia coli (ExPEC) severe threat to newborn health. O antigen is a highly variable component of lipopolysaccharide, serves as the main phenotypic marker for serotyping, and represents a promising target for vaccination…
  pubmed Zhang D, Zou P, Xiao R, Li J 等 2026 置信度 0.82
• Shear wave propagation in a prestressed and transversely isotropic viscoelastic material: Inverse modeling challenges and strategies.
  The functional role and structure of some biological tissues, such as skeletal muscle, result in anisotropy in both material properties and imposed stresses. Dynamic elastography reconstruction methods for estimating soft tissue viscoelastic properties that ar…
  pubmed Vorobyeva A, Wang Q, Klatt D, Ludvig D 等 2026 Aug 1 置信度 0.82
• Protocol to characterize tumor microenvironment in a diffuse midline glioma mouse model using multi-omics approach on sequential sections.
  Diffuse midline glioma (DMG) tumors form complex tumor-immune microenvironments with marked cellular heterogeneity. Here, we present a protocol to generate orthotopic DMG tumors in immunocompetent neonatal mice and to spatially characterize the tumor ecosystem…
  pubmed Collot R, Honhoff C, Ruiz-Moreno C, van Ineveld RL 等 2026 Aug 24 置信度 0.82
• Sexual dimorphisms in mechanisms of pressure natriuresis.
  Aim: The renal pressure-natriuresis response defines the blood pressure set point and maintains circulating volume. In male rats, the mechanisms involve trafficking and inactivation of renal proximal sodium transporters. Mechanisms may differ in females due to…
  pubmed McFarlin BE, Ralph DL, Koepsell H, Layton AT 等 2026 Aug 24 置信度 0.82
• Optimising the tilt increment for in situ cryo-electron tomography.
  Cryo-electron tomography (cryo-ET) enables high-resolution, three-dimensional imaging of cellular structures in their native, frozen state. However, image quality is limited by a trade-off between angular sampling and radiation damage. Therefore, the choice of…
  pubmed Tuijtel MW, Majtner T, Turoňová B, Beck M 2026 Aug 24 置信度 0.82
• miRSiC: a regulatory-aware machine learning framework for microRNA expression inference across bulk and single-cell transcriptomes.
  MicroRNAs (miRNAs) are key post-transcriptional regulators embedded in gene regulatory networks between upstream transcription factors (TFs) and downstream target genes (TGs), yet most computational approaches infer miRNA expression using unstructured transcri…
  pubmed Chen GT, Liang LC, Tang Y, Chen YC 等 2026 Jul 3 置信度 0.82
• DeepPANB: integrating protein language model with PaiNN equivariant graph neural networks for prediction of protein-nucleic acid binding sites.
  Protein-nucleic acid interactions are fundamental to various biological processes, and accurately identifying nucleic acid binding sites on proteins is essential for understanding gene regulation mechanisms and advancing drug design. Here, we present DeepPANB,…
  pubmed Zhang J, Wu Z, Su J, Zhang X 等 2026 Jul 3 置信度 0.82
• GLMYsymm: inferring symmetry categories of protein complexes from single sequences using persistent GLMY homology.
  Proteins often perform essential biological functions in the form of complexes. The assembly of protein complexes typically exhibits symmetry, which contributes to a more stable structural organization. Therefore, investigating structural symmetry is of great …
  pubmed Zhai J, Li J, Yau ST, Gong X 2026 Jul 3 置信度 0.82
• Dual-SVF: a robust knowledge-guided multimodal method for structural variant filtering in long-read sequencing.
  Structural variants (SVs) are key drivers of genomic diversity and disease, yet their accurate detection from long-read sequencing remains challenged by high false-positive rates caused by sequencing errors and alignment artifacts. Current filtering approaches…
  pubmed Lai C, Zhang H, Cheng C, Peng J 等 2026 Jul 3 置信度 0.82

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