基因技术工具

9598 条实体 · 最后更新 2026-10-16T09:46:23.215Z · computer science / data science / engineering / cs.ai / architecture / artificial intelligence / cs.lg / computer and information sciences / reinforcement learning / cs.hc / cs.cy / ai safety

• Reconstructing Past Admixture Processes from Local Genomic Ancestry Using Wavelet Transformation
  Admixture between long-separated populations is a defining feature of the genomes of many species. The mosaic block structure of admixed genomes can provide information about past contact events, including the time and extent of admixture. Here, we describe an…
  openalex Jean Sanderson, Herawati Sudoyo, Tatiana M. Karafet, Michael F. Hammer 等 2015-04-07 置信度 0.80 WaveletBiologyGenomeCoalescent theoryRange (aeronautics)
• When genomics goes digital
  openalex Evan D. Muse, Ali Torkamani, Eric J. Topol 2018-06-01 置信度 0.66 GenomicsComputational biologyComputer scienceBiologyGenetics
• Trypanosoma cruzi: Genomic Diversity and Structure
  Trypanosoma cruzi is the causative agent of Chagas disease, a neglected tropical disease, and one of the most important parasitic diseases worldwide. The first genome of T. cruzi was sequenced in 2005, and its complexity made assembly and annotation challengin…
  openalex Alfonso Herreros‐Cabello, Francisco Callejas‐Hernández, Núria Gironès, Manuel Fresno 2025-01-12 置信度 0.84 BiologyTrypanosoma cruziGenomeGeneGenetics
• Artificial Intelligence in Ayurveda: A Systematic Review (2020-2025)
  Background: Ayurveda, the ancient Indian system of medicine, emphasizes personalized holistic care, presenting unique opportunities for integration with Artificial Intelligence (AI). Since 2020, a growing body of research has explored AI applications in Ayurve…
  openalex Srishti Shaumya, R. Mathusoothana S. Kumar 2025-07-01 置信度 0.84 PsychologyData scienceArtificial intelligenceComputer scienceCognitive science
• Farm animal genetic and genomic resources from an agroecological perspective
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  openalex Michèle Tixier‐Boichard, Étienne Verrier, Xavier Rognon, Tatiana Zerjal 2015-04-30 置信度 0.66 AgroecologyGenomicsLivestockPerspective (graphical)Genetic resources
• TAREAN: a computational tool for identification and characterization of satellite DNA from unassembled short reads
  Satellite DNA is one of the major classes of repetitive DNA, characterized by tandemly arranged repeat copies that form contiguous arrays up to megabases in length. This type of genomic organization makes satellite DNA difficult to assemble, which hampers char…
  openalex Petr Novák, Laura Ávila Robledillo, Andrea Koblížková, Iva Vrbová 等 2017-04-05 置信度 0.80 BiologySatellite DNATandem repeatGenomeContig
• Population genomics highlights structural variations in local adaptation to saline coastal environments in woolly grape
  Structural variations (SVs) are a feature of plant genomes that has been largely unexplored despite their significant impact on plant phenotypic traits and local adaptation to abiotic and biotic stress. In this study, we employed woolly grape (Vitis retordii),…
  openalex Tianhao Zhang, Wenjing Peng, Hua Xiao, Shuo Cao 等 2024-04-05 置信度 0.84 Local adaptationBiologyAdaptation (eye)PopulationCandidate gene
• OrthoDB and BUSCO update: annotation of orthologs with wider sampling of genomes
  OrthoDB (https://www.orthodb.org) offers evolutionary and functional annotations of orthologous genes in the widest sampling of eukaryotes, prokaryotes, and viruses, extending experimental gene function knowledge to newly sequenced genomes. We collect gene ann…
  openalex Fredrik Tegenfeldt, Dmitry Kuznetsov, Mosè Manni, Matthew Berkeley 等 2024-11-12 置信度 0.84 BiologyGenomeGeneAnnotationGenetics
• Genetics, genomics and clinical features of adenomatous polyposis
  Adenomatous polyposis syndromes are hereditary conditions characterised by the development of multiple adenomas in the gastrointestinal tract, particularly in the colon and rectum, significantly increasing the risk of colorectal cancer and, in some cases, extr…
  openalex Jihoon E. Joo, Julen Viana-Errasti, Daniel D. Buchanan, Laura Valle 2025-04-16 置信度 0.84 MUTYHFamilial adenomatous polyposisBiologyAdenomatous polyposis coliDNA mismatch repair
• Personalized antisense oligonucleotides ‘for free, for life’ — the n-Lorem Foundation
  openalex Joseph G. Gleeson, C. Frank Bennett, Jeffrey B. Carroll, Tracy Cole 等 2023-05-11 置信度 0.64 OligonucleotideFoundation (evidence)Computational biologyBiologyMedicine
• Clinical and Genomic Risk for Late Breast Cancer Recurrence and Survival
  BACKGROUND: The 21-gene recurrence score (RS) assay (Oncotype DX) is used to guide adjuvant chemotherapy use for patients with hormone receptor-positive, HER2 (human epidermal growth factor receptor 2)-negative, axillary node-negative breast cancer. Its role, …
  openalex Joseph A. Sparano, Michael Crager, Robert J. Gray, Gong Tang 等 2024-07-23 置信度 0.84 Breast cancerMedicineOncologyCancerInternal medicine
• Multiomics of a rice population identifies genes and genomic regions that bestow low glycemic index and high protein content
  To counter the rising incidence of diabetes and to meet the daily protein needs, we created low glycemic index (GI) rice varieties with protein content (PC) surpassing 14%. In the development of recombinant inbred lines using Samba Mahsuri and IR36 amylose ext…
  openalex Saurabh Badoni, Erstelle A. Pasion-Uy, Sakshi Kor, Sung‐Ryul Kim 等 2024-08-27 置信度 0.84 AmyloseBiologyQuantitative trait locusGeneGenetics
• Genomic analysis of the natural history of attention-deficit/hyperactivity disorder using Neanderthal and ancient Homo sapiens samples
  Attention-deficit/hyperactivity disorder (ADHD) is an impairing neurodevelopmental condition highly prevalent in current populations. Several hypotheses have been proposed to explain this paradox, mainly in the context of the Paleolithic versus Neolithic cultu…
  openalex Paula Esteller-Cucala, Iago Maceda, Anders D. Børglum, Ditte Demontis 等 2020-05-25 置信度 0.82 NeanderthalContext (archaeology)AlleleIntrogressionAttention deficit hyperactivity disorder
• Genomic analysis of lean individuals with NAFLD identifies monogenic disorders in a prospective cohort study
  Background & Aims: Lean patients with non-alcoholic fatty liver disease (NAFLD) represent 10-20% of the affected population and may have heterogeneous drivers of disease. We have recently proposed the evaluation of patients with lean NAFLD without visceral adi…
  openalex Melanie Zheng, Daniel Q. Huang, Chigoziri Konkwo, Saaket Agrawal 等 2023-02-02 置信度 0.82 Fatty liverExome sequencingMedicineDiseaseExome
• Isolation of cDNAs encoding the complete sequence of bovine type X collagen. Evidence for the condensed nature of mammalian type X collagen genes
  The complete primary structure of the bovine alpha 1(X) collagen chain was determined by nucleotide sequencing of cDNA clones. The overlapping cDNA clones encode 3144 bp with a 5'-terminal untranslated region of 148 bp, a 2025 bp reading frame and a 3'-termina…
  openalex Jack Thomas, Alvin P.L. Kwan, Michael E. Grant, Ray Boot-Handford 1991-01-01 置信度 0.78 Complementary DNAUntranslated regionBiologyMolecular biologyExon
• Metabolic marker-assisted genomic prediction improves hybrid breeding
  Hybrid breeding is widely acknowledged as the most effective method for increasing crop yield, particularly in maize and rice. However, a major challenge in hybrid breeding is the selection of desirable combinations from the vast pool of potential crosses. Gen…
  openalex Yang Xu, Wenyan Yang, Jie Qiu, Kai Zhou 等 2024-11-28 置信度 0.84 Genomic selectionComputational biologyBiologyMarker-assisted selectionGenetics
• Genomic, molecular, and cellular divergence of the human brain
  While many core biological processes are conserved across species, the human brain has evolved with unique capacities. Current understanding of the neurobiological mechanisms that endow human traits as well as associated vulnerabilities remains limited. Howeve…
  openalex Ralda Nehme, Olli Pietiläinen, Lindy E. Barrett 2024-06-18 置信度 0.84 NeuroscienceHuman brainDivergence (linguistics)BiologyHuman genome
• Genomic adaptation of Clostridium perfringens to human intestine
  Abstract Clostridium perfringens is often associated with foodborne diseases, posing significant public health risks. However, genomic investigation of C. perfringens isolates from the human population has been lacking. This study aims to fill this knowledge g…
  openalex Ke Wu, Juan Wang, Zelin Yan, Yanyan Zhu 等 2024-10-25 置信度 0.84 Clostridium perfringensAdaptation (eye)MicrobiologyBiologyComputational biology
• Plant genomic and microbial interplay in the rhizosphere under salt stress: a review
  Soil salinization has been considered as a global problem in agriculture, which decreases crop productivity and threatens food security. Salt stress causes complex physiological damages in plants such as ionic imbalance, osmotic stress, and oxidative damage. H…
  openalex Yi Ren, He Yan, Aiyuan Ma 2026-01-07 置信度 0.84 RhizosphereBiologyRhizobacteriaMicrobiomeAbiotic stress
• Genomic Diversity as a Key Conservation Criterion: Proof‐of‐Concept From Mammalian Whole‐Genome Resequencing Data
  Many international, national, state, and local organizations prioritize the ranking of threatened and endangered species to help direct conservation efforts. For example, the International Union for Conservation of Nature (IUCN) assesses the Green Status of sp…
  openalex Jong Yoon Jeon, Andrew N. Black, Erangi J. Heenkenda, Andrew J. Mularo 等 2024-09-01 置信度 0.84 BiologyGenomeKey (lock)Computational biologyDiversity (politics)
• Gene-LLMs: a comprehensive survey of transformer-based genomic language models for regulatory and clinical genomics
  The convergence of natural language processing (NLP) and genomics has given rise to a new class of transformer-based models-genome large language models (Gene-LLMs)-capable of interpreting the language of life at an unprecedented scale and resolution. These mo…
  openalex P. Balakrishnan, A. Anny Leema, V. Dhivya Shree, Chadi Saad 等 2025-10-13 置信度 0.84 Computer scienceGenomicsInterpretabilityDECIPHERInference
• TNBC-DX genomic test in early-stage triple-negative breast cancer treated with neoadjuvant taxane-based therapy
  openalex M. Martín, S.R. Stecklein, Oleg Gluz, Guillermo Villacampa 等 2024-10-16 置信度 0.73 MedicineTaxaneTriple-negative breast cancerOncologyStage (stratigraphy)
• Policy implications of WHO’s global traditional medicine strategy 2025–2034
  aims to enhance the contribution of traditional, complementary and integrative medicine to achieving universal health coverage by strengthening the integration of evidence-based traditional, complementary and integrative medicine into national health systems. …
  openalex Yuk Ming Alice Wong, Sangyoungchol Ahn, Aditi Bana, Pradeep Kumar Dua 等 2025-11-01 置信度 0.84 Integrative medicineMisappropriationTraditional knowledgeIndigenousGlobal health
• Human β-defensins
  openalex Marzena Pazgier, David M. Hoover, De Yang, Weiyue Lu 等 2006-05-15 置信度 0.60 BiologyMicrobiologyChemistry
• The genomic origin of the unique chaetognath body plan
  Abstract The emergence of animal phyla, each with their unique body plan, was a rapid event in the history of animal life, yet its genomic underpinnings are still poorly understood1. Here we investigate at the genomic, regulatory and cellular levels, the origi…
  openalex Laura Piovani, Daria Gavriouchkina, Elise Parey, Luke A. Sarre 等 2025-08-13 置信度 0.84 Body planBiologyEvolutionary biologyZoologyComputational biology
• Antimicrobial resistance and genomic screening of clinical isolates of thermophilic Campylobacter spp. from south-east Queensland, Australia
  AIM: To screen 90 clinical isolates of thermophilic Campylobacter species for putative resistance to ampicillin, erythromycin and tetracycline and perform numerical analysis to determine isolate relatedness. METHODS AND RESULTS: Disc diffusion, E-test MIC and …
  openalex David A. Alfredson, R.J. Akhurst, Victoria Korolik 2003-03-01 置信度 0.78 TetracyclineErythromycinAgar dilutionAmpicillinCampylobacter
• Genomic diversity of Vibrio spp. and metagenomic analysis of pathogens in Florida Gulf coastal waters following Hurricane Ian
  ABSTRACT Changing climatic conditions influence parameters associated with the growth of pathogenic Vibrio spp. in the environment and, hence, are linked to increased incidence of vibriosis. Between 1992 and 2022, a long-term increase in Vibrio spp. infections…
  openalex Kyle D. Brumfield, Moiz Usmani, Sanneri Santiago, Komalpreet Singh 等 2023-10-16 置信度 0.82 VibrioVibrio vulnificusVibrio parahaemolyticusMetagenomicsBiology
• Genomic Profiling of Hormone-Naïve Lymph Node Metastases in Patients with Prostate Cancer
  The progression of organ-confined prostate cancer to metastatic cancer is inevitably fatal. Consequently, identification of structural changes in the genome and associated transcriptional responses that drive this progression is critical to understanding the d…
  openalex Pamela L. Paris, Matthias D. Hofer, Giancarlo Albo, Rainer Kuefer 等 2006-12-01 置信度 0.78 Prostate cancerLymph nodeComparative genomic hybridizationBiologyCopy number analysis
• MarkerDB 2.0: a comprehensive molecular biomarker database for 2025
  MarkerDB (https://markerdb.ca) has become a leading resource for comprehensive information on molecular biomarkers. Over the past 3 years, the database has evolved significantly, reflecting the dynamic landscape of biomarker research and increasing demands fro…
  openalex Hayley Jackson, Eponine Oler, Claudia Torres-Calzada, Ray Kruger 等 2024-10-25 置信度 0.84 BiomarkerUsabilityResource (disambiguation)Consistency (knowledge bases)Molecular biomarkers
• Social Genomic Determinants of Health: Understanding the Molecular Pathways by Which Neighborhood Disadvantage Affects Cancer Outcomes
  PURPOSE: Neighborhoods represent complex environments with unique social, cultural, physical, and economic attributes that have major impacts on disparities in health, disease, and survival. Neighborhood disadvantage is associated with shorter breast cancer re…
  openalex Neha Goel, Alexandra Hernández, Steve W. Cole 2024-08-23 置信度 0.84 Social determinants of healthPsychosocialHealth equitySocial epidemiologyDisease
• Sensitive and accurate detection of copy number variants using read depth of coverage
  Methods for the direct detection of copy number variation (CNV) genome-wide have become effective instruments for identifying genetic risk factors for disease. The application of next-generation sequencing platforms to genetic studies promises to improve sensi…
  openalex Seungtai Yoon, Zhenyu Xuan, Vladimir Makarov, Kenny Ye 等 2009-08-05 置信度 0.78 IndelCopy-number variationBiologyGenomeGenetics
• Blockchain-Based Privacy-Preserving System for Genomic Data Management Using Local Differential Privacy
  The advances made in genome technology have resulted in significant amounts of genomic data being generated at an increasing speed. As genomic data contain various privacy-sensitive information, security schemes that protect confidentiality and control access …
  openalex Young-Hoon Park, Yejin Kim, Junho Shim 2021-12-03 置信度 0.82 Differential privacyData sharingComputer scienceInformation privacyBlockchain
• Beyond genomics: artificial intelligence-powered diagnostics for indeterminate thyroid nodules—a systematic review and meta-analysis
  Introduction: In recent years, artificial intelligence (AI) tools have become widely studied for thyroid ultrasonography (USG) classification. The real-world applicability of these developed tools as pre-operative diagnostic aids is limited due to model overfi…
  openalex Karishma Jassal, Melissa Edwards, Afsaneh Koohestani, Wendy A. Brown 等 2025-05-05 置信度 0.84 IndeterminateThyroid nodulesGenomicsMeta-analysisMedicine
• Incorporating Genomics into Breast Cancer Clinical Trials and Care
  Advances in DNA sequencing provide the potential for clinical assays that are timely and affordable and use small amounts of clinical material. The hypothesis has therefore been raised that marked improvements in patient outcomes will result when DNA diagnosti…
  openalex Adel Tabchy, X. Cynthia, Ron Bose, Matthew J. Ellis 2013-12-01 置信度 0.80 DruggabilityGenomicsClinical trialCancerBreast cancer
• The polyploid continuum and the landscape of polyploid genomic variation
  Polyploid research has traditionally distinguished between autopolyploids and allopolyploids on the basis of evolutionary origins, modes of inheritance, or chromosomal pairing behavior during meiosis. It has long been recognized, however, that a binary classif…
  openalex Alex D. Twyford, Justin L. Conover, Jeff J. Doyle, Annaliese S. Mason 等 2025-11-01 置信度 0.84 PolyploidBiologyEvolutionary biologyPerspective (graphical)Ploidy
• Inferring effects of mutations on SARS-CoV-2 transmission from genomic surveillance data
  New and more transmissible variants of SARS-CoV-2 have arisen multiple times over the course of the pandemic. Rapidly identifying mutations that affect transmission could improve our understanding of viral biology and highlight new variants that warrant furthe…
  openalex Brian Lee, Ahmed Abdul Quadeer, Muhammad Saqib Sohail, Elizabeth Finney 等 2025-01-07 置信度 0.84 Transmission (telecommunications)BiologyGeneticsMutationComputational biology
• Genomic aberrations in diffuse low‐grade gliomas
  The current classification of diffuse low-grade gliomas is based mainly on histopathological criteria, which cannot accurately predict the highly variable clinical course observed in patients with such tumors. In an attempt to increase pathogenetic understandi…
  openalex Hanne‐Sofie S. Dahlback, Ludmila Gorunova, Petter Brandal, David Scheie 等 2011-03-15 置信度 0.80 Comparative genomic hybridizationKaryotypeBiologyGliomaPathology
• MEGA12: Molecular Evolutionary Genetic Analysis Version 12 for Adaptive and Green Computing
  We introduce the 12th version of the Molecular Evolutionary Genetics Analysis (MEGA12) software. This latest version brings many significant improvements by reducing the computational time needed for selecting optimal substitution models and conducting bootstr…
  openalex Sudhir Kumar, Glen Stecher, Michael Suleski, Maxwell Sanderford 等 2024-12-01 置信度 0.80 BiologyAdaptive evolutionEvolutionary biologyMolecular evolutionComputational biology
• Strategies for microsatellite isolation: a review
  In the last few years microsatellites have become one of the most popular molecular markers used with applications in many different fields. High polymorphism and the relative ease of scoring represent the two major features that make microsatellites of large …
  openalex Lorenzo Zane, Luca Bargelloni, Tomaso Patarnello 2002-01-01 置信度 0.74 MicrosatelliteBiologyIsolation (microbiology)Computational biologyEvolutionary biology
• Cloning and characterization of the genomic DNA of the human MSSP genes
  MSSP proteins have been identified by their binding to an upstream element of c-myc. Independently, two different approaches yielded two cDNA clones highly homologous to the MSSP cDNAs, suggesting an involvement of MSSP in the regulation of the cell cycle (scr…
  openalex Christian Haigermoser 1996-10-01 置信度 0.78 BiologyGeneGeneticsPromoterExon
• Genomic markers of recurrence risk in atypical meningioma following gross total resection
  Abstract Background Meningiomas are the most common primary central nervous system (CNS) tumor in adults and CNS World Health Organization grade 2 (atypical) meningiomas show an intermediate risk of recurrence/progression. Molecular parameters are needed to be…
  openalex Rachael A. Vaubel, Rahul Kumar, Taylor M. Weiskittel, Sarah M. Jenkins 等 2023-01-01 置信度 0.82 ResectionMeningiomaMedicineBiologyGenetics
• Comparing methods for detecting multilocus adaptation with multivariate genotype–environment associations
  Identifying adaptive loci can provide insight into the mechanisms underlying local adaptation. Genotype-environment association (GEA) methods, which identify these loci based on correlations between genetic and environmental data, are particularly promising. U…
  openalex Brenna R. Forester, Jesse R. Lasky, Helene H. Wagner, Dean L. Urban 2018-04-09 置信度 0.80 UnivariateBiologyMultivariate statisticsSelection (genetic algorithm)Local adaptation
• Stage-Specific Transcriptome and Proteome Analyses of the Filarial Parasite Onchocerca volvulus and Its Wolbachia Endosymbiont
  Onchocerciasis (river blindness) is a neglected tropical disease that has been successfully targeted by mass drug treatment programs in the Americas and small parts of Africa. Achieving the long-term goal of elimination of onchocerciasis, however, requires add…
  openalex Sasisekhar Bennuru, James A. Cotton, José M. C. Ribeiro, Alexandra Grote 等 2016-11-24 置信度 0.80 Onchocerca volvulusWolbachiaParasite hostingProteomeTranscriptome
• High concordance of actionable genomic alterations identified between circulating tumor DNA–based and tissue‐based next‐generation sequencing testing in advanced non–small cell lung cancer: The Korean Lung Liquid Versus Invasive Biopsy Program
  BACKGROUND: Because of the growing number of actionable biomarkers in non-small cell lung cancer (NSCLC), sufficient tissue availability for testing is becoming a greater challenge. Liquid biopsy offers a potential solution by complementing standard tissue-bas…
  openalex Sehhoon Park, Steve Olsen, Bo Mi Ku, Min‐Sang Lee 等 2021-04-07 置信度 0.82 ConcordanceMedicineLung cancerDNA sequencingPathology
• Cancer treatment and survivorship statistics, 2025: An urgent call to optimize health after cancer
  The publication of the American Cancer Society’s “Cancer Treatment and Survivorship Statistics, 2025” report affirms that the number of people living in the United States with a history of cancer is rising because of advances in detection and treatment that ha…
  openalex Lidia Schapira, Christine Duffy 2025-05-30 置信度 0.84 MedicineSurvivorship curveCancer survivorshipCancerCancer treatment
• Discoveries and advances in plant and animal genomics
  Plant and animal genomics is a broad area of research with respect to the biological issues covered because it continues to deal with the structure and function of genetic material underpinning all organisms. This mini-review utilizes the plenary lectures from…
  openalex R. Appels, Johan Nyström, Hollie Webster, Gabriel Keeble‐Gagnère 2015-03-01 置信度 0.78 GenomicsBiologyUnderpinningGenomeComputational biology
• A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)γa as a pancreatic beta cell-specific biomarker
  openalex Daisy Flamez, I. Roland, Alix Berton, Burak Kutlu 等 2010-04-08 置信度 0.67 Beta cellBiologyPancreatic isletsPancreasCell biology
• Genomic hallmarks of endocrine therapy resistance in ER/PR+HER2- breast tumours
  ER/PR+HER2- breast tumours are the most predominant subtype of breast cancer worldwide, including India. Unlike TNBCs, these tumours can be treated with anti-estrogens or aromatase inhibitors. Despite the success of endocrine therapy, a fraction of patients wi…
  openalex Arnab Ghosh, Rohan Chaubal, Chitrarpita Das, Pallavi Parab 等 2025-02-10 置信度 0.84 Breast cancerGenome instabilityEndocrine systemOncologyInternal medicine
• Post-genomic challenges for collaborative research in infectious diseases
  openalex Iruka N. Okeke, John Wain 2008-08-19 置信度 0.60 BiologyComputational biologyInfectious disease (medical specialty)VirologyGenetics
• Dollo’s law of irreversibility in the post-genomic age
  Dollo's law of irreversibility argues that evolution cannot revert to earlier states. It has remained controversial ever since its inception in the 19th century. Enabled by advances in phylogenomics and functional genomics, recent studies show that there are v…
  openalex Kathryn R. Elmer, Jean Clobert 2024-10-23 置信度 0.79 LawPolitical science
• AACR Pediatric Cancer Progress Report 2025
  On December 4, 2025, the American Association for Cancer Research (AACR) released its inaugural AACR Pediatric Cancer Progress Report, which highlights the remarkable scientific and clinical advances transforming outcomes for children (ages 0-14) and adolescen…
  openalex Kristin Primm, Elizabeth Blackman, Brett M. Sansbury, Sayyed Kaleem Zaidi 等 2026-02-04 置信度 0.84 MedicinePediatric cancerCancerMEDLINEPediatric research
• Genomics: what is realistically achievable?
  We now have a large and growing number of sequenced genomes. It is widely understood that this presents research opportunities and promises to change the way biology advances, but the magnitude and nature of the opportunities is, for the most part, poorly unde…
  openalex Ross Overbeek 2000-01-01 置信度 0.78 Data scienceComputer scienceField (mathematics)GenomicsFace (sociological concept)
• Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma
  Mitogen-activated protein kinase/extracellular signal-regulated protein kinase (MAPK/ERK) is a key molecule in intracellular signal transducing pathways that transport extracellular stimuli from cell surface to nuclei. MAPK/ERK has been revealed to be involved…
  openalex Yoshiki Ito, Yutaka Sasaki, Masayoshi Horimoto, Shigeo Wada 等 1998-04-01 置信度 0.78 MAPK/ERK pathwayKinaseCancer researchProtein kinase ACyclin D1
• Recent Advances in the Genomic Profiling of Bacterial Epigenetic Modifications
  Bacterial epigenetic modifications play key roles in cellular processes such as stress responses, DNA replication, segregation, antimicrobial resistance, etc. In recent years, emerging new sequencing technologies, including single-molecule real-time (SMRT) seq…
  openalex Liqiong Liu, Yizhou Zhang, Dongxu Jiang, Shiming Du 等 2018-06-07 置信度 0.80 EpigeneticsComputational biologyProfiling (computer programming)BiologyGenetics
• Recommendations for improving statistical inference in population genomics
  ABSTRACT The field of population genomics has grown rapidly in response to the recent advent of affordable, large-scale sequencing technologies. As opposed to the situation during the majority of the 20th century, in which the development of theoretical and st…
  openalex Parul Johri, Charles F. Aquadro, Mark Beaumont, Brian Charlesworth 等 2021-11-02 置信度 0.82 InferenceData scienceScrutinyPopulationStatistical inference
• Metagenomic global survey and in-depth genomic analyses of Ruminococcus gnavus reveal differences across host lifestyle and health status
  Ruminococcus gnavus is a gut bacterium found in > 90% of healthy individuals, but its increased abundance is also associated with chronic inflammatory diseases, particularly Crohn's disease. Nevertheless, its global distribution and intraspecies genomic variat…
  openalex Sam Nooij, Niels Plomp, Ingrid M. J. G. Sanders, L. Schout 等 2025-01-30 置信度 0.84 MetagenomicsHost (biology)RuminococcusBiologyEnvironmental health
• A Review of the Molecular Understanding of the Mpox Virus (MPXV): Genomics, Immune Evasion, and Therapeutic Targets
  The Mpox virus (MPXV), a zoonotic pathogen from the Orthopoxvirus genus, has emerged as a significant global public health concern, especially after the unprecedented outbreak in 2022. This review synthesizes the MPXV’s molecular features, focusing on its geno…
  openalex Edgar Cambaza 2025-01-16 置信度 0.84 Evasion (ethics)Immune systemGenomicsBiologyFunctional genomics
• Darwin: A Hardware-acceleration Framework for Genomic Sequence Alignment
  ABSTRACT Genomics is set to transform medicine and our understanding of life in fundamental ways. But the growth in genomics data has been overwhelming - far outpacing Moore’s Law. The advent of third generation sequencing technologies is providing new insight…
  openalex Yatish Turakhia, Kevin Jie Zheng, Gill Bejerano, William J. Dally 2017-01-15 置信度 0.80 SpeedupComputer scienceGenomicsDarwin (ADL)Hardware acceleration
• SWI/SNF Complex-Deficient Undifferentiated Carcinoma of the Pancreas: Clinicopathologic and Genomic Analysis
  openalex Aslihan Yavas, Kerem Özcan, Volkan Adsay, Serdar Balcı 等 2024-07-31 置信度 0.69 PathologyHematopathologyPancreasMedicineCarcinoma
• Genomic and Experimental Analysis of the Biostimulant and Antagonistic Properties of Phytopathogens of Bacillus safensis and Bacillus siamensis
  The B. safensis RGM 2450 and B. siamensis RGM 2529 strains were isolated from the rhizosphere of plants presenting resilience to abiotic and biotic stress conditions. To understand the implications of bacteria in resilience, a genomic and experimental analysis…
  openalex Fabiola Altimira, Sebastián Godoy, Matías Arias-Aravena, Bárbara Araya 等 2022-03-22 置信度 0.82 BiologyRhizosphereFusarium oxysporumInoculationBotany
• Twelve New Genomic Loci Associated With Bone Mineral Density
  Aiming to identify more genomic loci associated with bone mineral density (BMD), we conducted a joint association analysis of 2 genome-wide association study (GWAS) by the integrative association method multi-trait analysis of GWAS (MTAG). The first one is the…
  openalex Lu Liu, Min Zhao, Zonggang Xie, Ju Liu 等 2020-04-22 置信度 0.82 Genome-wide association studyQuantitative trait locusExpression quantitative trait lociGenetic associationLocus (genetics)
• Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling
  openalex Isabelle F. Foote, Jonny P Flint, Anna E. Fürtjes, Jeremy M Lawrence 等 2025-08-01 置信度 0.69 BiologyMultivariate statisticsStructural equation modelingGenetic architectureMultivariate analysis
• Genomic Epidemiology of West Nile Virus in Paris
  Importance: West Nile virus (WNV), a mosquito-borne orthoflavivirus, represents an increasing public health threat in Europe. In July 2025, WNV lineage 2 (WNV-L2) was associated with the first autochthonous cases ever detected in the metropolitan area around P…
  openalex Raphaelle Klitting, Mathilde Gondard, Laura Pezzi, Camille Victoire Migné 等 2026-02-16 置信度 0.84 Biological dispersalWest Nile virusBiologyVirologyEpidemiology
• Report of the 47th annual conference and the golden jubilee year meeting of the Environmental Mutagen Society of India (EMSI) and international conference on environmental and molecular mutagenesis: genomic integrity and implication to human health, Tamil Nadu, India, January 29–31, 2025
  The 47th Annual Conference and the Golden Jubilee Year Meeting of the Environmental Mutagen Society of India (EMSI) and International Conference on Environmental and Molecular Mutagenesis: Genomic Integrity and Implication to Human Health was held at the Depar…
  openalex Bani Bandana Ganguly 2025-04-25 置信度 0.84 MutagenPolitical scienceLibrary scienceBiotechnologyBiology
• Genomics in plant pathogen identification and control
  Recent advances in genomics have revolutionized plant pathogen detection and control by enabling faster and more accurate identification compared to traditional culture-based methods. Genomic tools like metagenomics and next generation sequencing (NGS) facilit…
  openalex Nkechi Gloria Ogbuji, Josephine U. Agogbua 2025-11-05 置信度 0.84 BiologyGenomicsCRISPRMetagenomicsIdentification (biology)
• The genomic and cellular basis of biosynthetic innovation in rove beetles
  openalex Sheila A. Kitchen, Thomas H. Naragon, Adrian Brückner, Mark S. Ladinsky 等 2024-06-17 置信度 0.69 BiologyComputational biologyBiotechnologyGenetics
• Kolmogorov–Arnold networks for genomic tasks
  Kolmogorov-Arnold networks (KANs) emerged as a promising alternative for multilayer perceptrons (MLPs) in dense fully connected networks. Multiple attempts have been made to integrate KANs into various deep learning architectures in the domains of computer vis…
  openalex Oleksandr Cherednichenko, Maria Poptsova 2025-03-01 置信度 0.84 Computer scienceGenomic medicineComputational biologyArtificial intelligenceBiology
• The International Weed Genomics Consortium: Community Resources for Weed Genomics Research
  Abstract The International Weed Genomics Consortium is a collaborative group of researchers focused on developing genomic resources for the study of weedy plants. Weeds are attractive systems for basic and applied research due to their impacts on agricultural …
  openalex Jacob S. Montgomery, Sarah Morran, Dana R. MacGregor, J. Scott McElroy 等 2023-07-20 置信度 0.82 WeedGenomicsAgricultureWeed controlSelection (genetic algorithm)
• MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG
  Abstract Reactive oxygen species (ROS) oxidize nucleotide triphosphate pools (e.g., 8-oxodGTP), which may kill cells if incorporated into DNA. Whether cancers avoid poisoning from oxidized nucleotides by preventing incorporation via the oxidized purine diphosp…
  openalex Sean G. Rudd, Helge Gad, Kumar Sanjiv, Nuno Amaral 等 2020-04-20 置信度 0.82 MitosisDNA damageBiologyDNA replicationMitotic catastrophe
• The genomic history of East Asian Middle Neolithic millet- and rice-agricultural populations
  The Yellow and Yangtze river basins in China are among the world's oldest independent agricultural centers, known for the domestication of millet and rice, respectively, yet their genetic history is poorly understood. Here, we present genome-wide data from 74 …
  openalex Jianxue Xiong, Xu Yu, Guoke Chen, Liping Yang 等 2025-08-19 置信度 0.84 AgricultureMiddle EastGeographyAncient historyAgronomy
• Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example
  The current paradigm of personalized medicine envisages the use of genomic data to provide predictive information on the health course of an individual with the aim of prevention and individualized care. However, substantial efforts are required to realize the…
  openalex Bram P. Prins, Liis Leitsalu, Katri Pärna, Krista Fischer 等 2021-04-29 置信度 0.82 Personalized medicinePrecision medicineGenomic medicineData scienceHealth care
• Genomic evidence for low genetic diversity but purging of strong deleterious variants in snow leopards
  BACKGROUND: Long-term persistence of species with low genetic diversity is the focus of widespread attention in conservation biology. The snow leopard, Panthera uncia, is a big cat from high-alpine regions of Asia. However, its subspecies taxonomy, evolutionar…
  openalex Lin Yang, Hongjian Jin, Qi‐En Yang, Andrey D. Poyarkov 等 2025-04-14 置信度 0.84 BiologyHuman geneticsEvolutionary biologyGeneticsGenetic diversity
• Understanding variants of unknown significance and classification of genomic alterations
  Despite recent efforts to issue clinical guidelines outlining strategies to define the pathogenicity of genomic variants, there is currently no standardized framework for which to make these assertions. This review does not present a step-by-step methodology, …
  openalex Dean C. Pavlick, Garrett M. Frampton, Jeffrey R Ross 2024-05-30 置信度 0.84 Context (archaeology)Computational biologyPathogenicityScope (computer science)Perspective (graphical)
• Comprehensive genomic profiling of over 10,000 advanced solid tumors
  // Jean-Paul De La O 1 , Jess R. Hoag 1 , Angela K. Deem 1 , Min Wang 1 , Arthur Starodynov 1 , Sameer S. Udhane 1 , Janine R. LoBello 1 , Nishitha Therala 1 , David W. Hall 1 , Gargi D. Basu 1 and Frederick L. Baehner 1 1 Exact Sciences Corporation, Madison, …
  openalex Jean-Paul De La O, Jess Hoag, Angela K. Deem, Min Wang 等 2025-07-25 置信度 0.84 MedicineSolid tumorInternal medicineProstate cancerOncology
• Evaluating the Cost of Genomic Testing for Biomarker-Driven Therapies in Oncology
  INTRODUCTION: Genomic profiling is used in the diagnosis, monitoring, and treatment of malignancies. Comprehensive genomic profiling (CGP) is a next-generation sequencing (NGS) approach that can test multiple genes simultaneously, potentially saving time, mone…
  openalex Jamie Partridge Grossman, Elizabeth A. Sheppard, Zhuofan Yan, Magdalene Crabbe 等 2026-02-18 置信度 0.84 MedicineCalculatorPrecision oncologyPrecision medicineClinical Practice
• Genomic rearrangements of hMSH6 contribute to the genetic predisposition in suspected hereditary non-polyposis colorectal cancer syndrome: Figure 1
  BACKGROUND: Germline mutations in mismatch repair genes, mainly in hMLH1, hMSH2, and hMSH6, predispose to the hereditary non-polyposis colorectal cancer (HNPCC) syndrome. A substantial fraction of these mutations exists in genomic rearrangements of hMSH2 and h…
  openalex Jens Plaschke, J Rüschoff, H K Schackert 2003-08-01 置信度 0.78 ExonBiologyGeneticsGermlineGermline mutation
• Repeatability of evolution and genomic predictions of temperature adaptation in seed beetles
  Climate warming is threatening biodiversity by increasing temperatures beyond the optima of many ectotherms. Owing to the inherent non-linear relationship between temperature and the rate of cellular processes, such shifts towards hot temperature are predicted…
  openalex Alexandre Rêgo, Julian Baur, Camille Girard‐Tercieux, Maria de la Paz Celorio‐Mancera 等 2025-05-16 置信度 0.84 RepeatabilityAdaptation (eye)BiologyEvolutionary biologyBiological system
• Dosage-sensitive miRNAs trigger modulation of gene expression during genomic imbalance in maize
  The genomic imbalance caused by varying the dosage of individual chromosomes or chromosomal segments (aneuploidy) has more detrimental effects than altering the dosage of complete chromosome sets (ploidy). Previous analysis of maize (Zea mays) aneuploids revea…
  openalex Xiaowen Shi, Hua Yang, Chen Chen, Jie Hou 等 2022-05-31 置信度 0.82 microRNABiologyGene dosageGeneAneuploidy
• The Origins of Coca: Museum Genomics Reveals Multiple Independent Domestications from ProgenitorErythroxylum gracilipes
  Coca is the natural source of cocaine as well as a sacred and medicinal plant farmed by South American Amerindians and mestizos. The coca crop comprises four closely related varieties classified into two species (Amazonian and Huánuco varieties within Erythrox…
  openalex Dawson M. White, Jen‐Pan Huang, Orlando Adolfo Jara-Muñoz, Santiago Madriñán 等 2020-09-17 置信度 0.82 DomesticationCocaBiologyAmazon rainforestAmazonian
• JARVIS3: an efficient encoder for genomic data
  MOTIVATION: Large-scale genomic projects grapple with the complex challenge of reducing medium- and long-term storage space and its associated energy consumption, monetary costs, and environmental footprint. RESULTS: We present JARVIS3, an advanced tool engine…
  openalex Maria J P Sousa, Armando J. Pinho, Diogo Pratas 2024-11-28 置信度 0.84 Computer scienceData compressionCompression (physics)ComputationMemory footprint
• Genomics‐driven prophylactic measures to increase streptococcosis resistance in tilapia
  Streptococcosis caused by Streptococcus agalactiae and S. iniae is a significant problem that affects the success of tilapia aquaculture industries worldwide. In this critical review, we summarize the applicable practical strategies which may effectively enhan…
  openalex Pattanapon Kayansamruaj, Nguyen Dinh‐Hung, Prapansak Srisapoome, Uthairat Na‐Nakorn 等 2023-01-28 置信度 0.82 TilapiaBiologyAquacultureGenomicsBiotechnology
• CRISPRi-ART enables functional genomics of diverse bacteriophages using RNA-binding dCas13d
  Bacteriophages constitute one of the largest reservoirs of genes of unknown function in the biosphere. Even in well-characterized phages, the functions of most genes remain unknown. Experimental approaches to study phage gene fitness and function at genome sca…
  openalex Benjamin A. Adler, Muntathar Al-Shimary, Jaymin R. Patel, Emily G. Armbruster 等 2025-02-26 置信度 0.84 BiologyGeneCRISPRGenomeFunctional genomics
• Whose Odyssey Is It? Family‐Centered Care in the Genomic Era
  Despite a century of progress in medical knowledge, many diagnostic odysseys end in disappointment, especially when the child has a developmental disorder. In cases of autism and intellectual disability, relatively few children receive a specific diagnosis, an…
  openalex Jeffrey P. Brosco 2018-07-01 置信度 0.80 DisappointmentMedical diagnosisExome sequencingIntellectual disabilityPsychology
• Genomics identifies koala populations at risk across eastern Australia
  Koalas are an iconic, endangered, Australian marsupial. Disease, habitat destruction, and catastrophic mega-fires have reduced koalas to remnant patches of their former range. With increased likelihood of extreme weather events and ongoing habitat clearing acr…
  openalex Elspeth A. McLennan, Toby G. L. Kovacs, Luke W. Silver, Zhiliang Chen 等 2024-11-29 置信度 0.84 Phascolarctos cinereusBiologyEcologyRange (aeronautics)Habitat
• The Cost Effectiveness of Genomic Medicine in Cancer Control: A Systematic Literature Review
  BACKGROUND AND OBJECTIVE: Genomic medicine offers an unprecedented opportunity to improve cancer outcomes through prevention, early detection and precision therapy. Health policy makers worldwide are developing strategies to embed genomic medicine in routine c…
  openalex Mackenzie Bourke, Aideen McInerney‐Leo, Julia Steinberg, Tiffany Boughtwood 等 2025-03-29 置信度 0.84 MedicinePersonalized medicineCINAHLCost effectivenessMEDLINE
• Genomic characteristics and epidemic trends of NADC30-like PRRSV in China
  BACKGROUND: NADC30-like PRRSV was first identified in China in 2012 and had become the predominant circulating strain since 2016. Currently, the recombination patterns of NADC30-like PRRSV in China exhibit a high degree of complexity, characterized by low whol…
  openalex Siyu Zhang, Xu Hu, Zhenyang Guo, Lirun Xiang 等 2025-05-28 置信度 0.84 GenBankGeneticsBiologyPhylogenetic treeRecombination
• An Overview of the Molecular Mechanisms of Recombinational DNA Repair
  Recombinational DNA repair is a universal aspect of DNA metabolism and is essential for genomic integrity. It is a template-directed process that uses a second chromosomal copy (sister, daughter, or homolog) to ensure proper repair of broken chromosomes. The k…
  openalex Stephen C. Kowalczykowski 2015-11-01 置信度 0.76 BiologyMolecular geneticsGeneticsDNADNA repair
• The Role of Genomics in Advancing and Standardising Bacteriophage Therapy
  Bacteriophage therapy, which employs bacterial viruses to selectively eliminate pathogenic bacteria, has re-emerged as a promising strategy in the face of increasing antimicrobial resistance. However, its widespread clinical implementation is constrained by co…
  openalex Narina Abdraimova, Egor Shitikov, Maria Kornienko 2026-01-04 置信度 0.84 Phage therapyBacteriophageComputational biologyGenomicsBiology
• Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases
  Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect several million individuals worldwide. Crohn's disease and ulcerative colitis are complex diseases that are heterogeneous at the clinical, immunological, molecular, genet…
  openalex Jason Lloyd‐Price, Cesar Arze, Ashwin N. Ananthakrishnan, Melanie Schirmer 等 2019-05-29 置信度 0.82 Inflammatory Bowel DiseasesOmicsGut floraInflammatory bowel diseaseEcosystem
• Terpenoid biomaterials
  Terpenoids (isoprenoids) encompass more than 40 000 structures and form the largest class of all known plant metabolites. Some terpenoids have well-characterized physiological functions that are common to most plant species. In addition, many of the structural…
  openalex Jörg Bohlmann, Christopher I. Keeling 2008-05-01 置信度 0.78 TerpenoidContext (archaeology)Biochemical engineeringChemistryBiology
• Epstein-Barr virus BRLF1 induces genomic instability and progressive malignancy in nasopharyngeal carcinoma cells
  // Sheng-Yen Huang 1 , Chung-Chun Wu 1 , Yu-Jhen Cheng 1 , Sheng-Ping Chou 1 , Yun-Jin Jiang 2 , Kuo-Chang Chu 2 , Ching-Hwa Tsai 3 , Su-Fang Lin 1 and Jen-Yang Chen 1, 3 1 National Institute of Cancer Research, National Health Research Institutes, Miaoli 3505…
  openalex Sheng‐Yen Huang, Chung-Chun Wu, Yu-Jhen Cheng, Sheng‐Ping Chou 等 2017-09-05 置信度 0.80 Nasopharyngeal carcinomaGenome instabilityMalignancyEpstein–Barr virusCancer research
• Genomics Define Malignant Transformation in Myeloma Precursor Conditions
  Multiple myeloma (MM) is consistently preceded by monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). While these precursor conditions are asymptomatic, they are not entirely benign and carry a lifelong risk of prog…
  openalex Francesco Maura, P. Leif Bergsagel, Bachisio Ziccheddu, Shaji Kumar 等 2025-10-08 置信度 0.84 Multiple myelomaMalignant transformationMonoclonal gammopathy of undetermined significanceGenomicsMedicine
• Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood
  openalex Yasminka A. Jakubek, Xiaolong Ma, Adrienne M. Stilp, Fulong Yu 等 2025-01-13 置信度 0.65 BiologyGeneticsPhenotypeHaplotypeAllele
• Genomic epidemiology analysis of drug-resistant Mycobacterium tuberculosis distributed in Mexico
  Genomics has significantly revolutionized pathogen surveillance, particularly in epidemiological studies, the detection of drug-resistant strains, and disease control. Despite its potential, the representation of Latin American countries in the genomic catalog…
  openalex Paulina M. Mejía‐Ponce, Elsy Janeth Ramos-González, Axel Alejandro Ramos-García, Edgar E. Lara‐Ramírez 等 2023-10-13 置信度 0.82 Mycobacterium tuberculosisDrug resistanceTuberculosisBiologyGenotype
• Epstein–Barr virus infection and nasopharyngeal carcinoma
  Epstein-Barr virus (EBV) is associated with multiple types of human cancer, including lymphoid and epithelial cancers. The closest association with EBV infection is seen in undifferentiated nasopharyngeal carcinoma (NPC), which is endemic in the southern Chine…
  openalex Sai Wah Tsao, Chi Man Tsang, Kwok Wai Lo 2017-09-11 置信度 0.80 Nasopharyngeal carcinomaLytic cycleEpstein–Barr virusBiologyVirus
• WheatGP, a genomic prediction method based on CNN and LSTM
  Wheat plays a crucial role in ensuring food security. However, its complex genetic structure and trait variation pose significant challenges for breeding superior varieties. In this study, a genomic prediction method for wheat (WheatGP) is proposed. WheatGP is…
  openalex Chunying Wang, Di Zhang, Yuexin Ma, Yonghao Zhao 等 2025-03-01 置信度 0.84 Computer scienceConvolutional neural networkArtificial intelligenceEpistasisRegression
• Population genomics analyses reveal the role of hybridization in the rapid invasion of fall armyworm
  INTRODUCTION: Invasive species pose a major threat to global biodiversity and agricultural productivity, yet the genomic mechanisms driving their rapid expansion into new habitats are not fully understood. The fall armyworm, Spodoptera frugiperda, originally f…
  openalex Xuan Wang, Zhenyong Du, Yuange Duan, Shanlin Liu 等 2024-09-30 置信度 0.84 Population genomicsGenomicsBiologyPopulationComputational biology
• Inference of Population Splits and Mixtures from Genome-Wide Allele Frequency Data
  Many aspects of the historical relationships between populations in a species are reflected in genetic data. Inferring these relationships from genetic data, however, remains a challenging task. In this paper, we present a statistical model for inferring the p…
  openalex Joseph K. Pickrell, Jonathan K. Pritchard 2012-11-15 置信度 0.80 BiologyDomesticationEvolutionary biologyInferencePopulation
• The Genomic Signature of Population Reconnection Following Isolation: From Theory to HIV
  Ease of worldwide travel provides increased opportunities for organisms not only to colonize new environments but also to encounter related but diverged populations. Such events of reconnection and secondary contact of previously isolated populations are widel…
  openalex Nicolas Alcala, Jeffrey D. Jensen, Amalio Telenti, Séverine Vuilleumier 2015-11-10 置信度 0.80 Coalescent theoryBiologyPopulationEvolutionary biologyDemographic history
• Nivolumab plus Ipilimumab in Advanced Non–Small-Cell Lung Cancer
  BACKGROUND: In an early-phase study involving patients with advanced non-small-cell lung cancer (NSCLC), the response rate was better with nivolumab plus ipilimumab than with nivolumab monotherapy, particularly among patients with tumors that expressed program…
  openalex Matthew D. Hellmann, Luis Paz‐Ares, Reyes Bernabe Caro, Bogdan Żurawski 等 2019-09-28 置信度 0.82 NivolumabIpilimumabMedicineLung cancerOncology
• A sex-informed approach to improve the personalised decision making process in myelodysplastic syndromes: a multicentre, observational cohort study
  BACKGROUND: Sex is a major source of diversity among patients and a sex-informed approach is becoming a new paradigm in precision medicine. We aimed to describe sex diversity in myelodysplastic syndromes in terms of disease genotype, phenotype, and clinical ou…
  openalex Giulia Maggioni, Matteo Bersanelli, Erica Travaglino, Ana Alfonso Piérola 等 2022-11-25 置信度 0.82 MedicineMyelodysplastic syndromesCohortObservational studyPopulation
• Avian influenza overview March–June 2025
  Abstract Between 8 March and 6 June 2025, 365 highly pathogenic avian influenza (HPAI) A(H5) virus detections were reported in domestic (167) and wild (198) birds across 24 countries in Europe. HPAI A(H5N1) virus detections were predominant and mainly located …
  openalex European Food Safety Authority, Leonidas Alexakis, Hubert Buczkowski, Mariette Ducatez 等 2025-07-01 置信度 0.84 Influenza A virus subtype H5N1WaterfowlVeterinary medicineHighly pathogenicInfluenza A virus
• Genomic and Expression Analyses Identify a Disease-Modifying Variant for Fibrostenotic Crohn’s Disease
  Background and Aims: Crohn's disease [CD] is a chronic inflammatory disease with unpredictable behaviour. More than half of CD patients eventually develop complications such as stenosis, for which they then require endoscopic dilatation or surgery, as no anti-…
  openalex Marijn C. Visschedijk, Lieke M. Spekhorst, Shih‐Chin Cheng, Ellen S. van Loo 等 2018-01-16 置信度 0.80 WWOXSingle-nucleotide polymorphismSNPCrohn's diseaseAllele
• Technical note: Comparative analyses of the quality and yield of genomic DNA from invasive and noninvasive, automated and manual extraction methods
  Several new automated methods have recently become available for high-throughput DNA extraction, including the Maxwell 16 System (Promega UK, Southampton, UK). The purpose of this report is to compare automated with manual DNA extraction methods, and invasive …
  openalex Cathriona Foley, Cliona O’Farrelly, Kieran G. Meade 2011-05-25 置信度 0.80 DNA extractionSemenBuffy coatExtraction (chemistry)DNA
• Ecological connectivity of genomic markers of antimicrobial resistance in Escherichia coli in Hong Kong
  Antibiotic-resistant Escherichia coli (E. coli) is a major contributor to the global burden of antimicrobial resistance (AMR). While the One Health concept emphasizes the connection of human, animal, and environmental health, genome-resolved and quantitatively…
  openalex Xiaoqing Xu, Yunqi Lin, Yu Deng, Lei Liu 等 2025-08-08 置信度 0.84 BiologyAntibiotic resistancePlasmidEscherichia coliGenome
• A nationwide comprehensive genomic profiling and molecular tumor board platform for patients with advanced cancer
  The Belgian Approach for Local Laboratory Extensive Tumor Testing (BALLETT) study assessed the feasibility of using comprehensive genomic profiling (CGP) in clinical decision-making for patients with advanced cancers. This multi-center study enrolled 872 patie…
  openalex Pieter‐Jan Volders, Philippe Aftimos, Franceska Dedeurwaerdere, Geert A. Martens 等 2025-03-10 置信度 0.84 MedicineStandardizationOncologyProfiling (computer programming)Turnaround time
• Genomic landscape and preclinical models of angiosarcoma
  Angiosarcoma is a cancer that develops in blood or lymphatic vessels that presents a significant clinical challenge due to its rarity and aggressive features. Clinical outcomes have not improved in decades, highlighting a need for innovative therapeutic strate…
  openalex Annaleigh Benton, Bozhi Liu, Lauren E. Gartenhaus, Jason A. Hanna 2024-10-05 置信度 0.84 AngiosarcomaDiseaseComputational biologyBiologyMedicine
• Genomic epidemiology and antifungal resistance of emerging Trichophyton indotineae in China
  Trichophyton indotineae is an emerging pathogenic fungus of growing concern due to its drug resistance and therapeutic challenges posing to dermatophytosis [1, 2]. Initially classified as T. mentag...
  openalex Wenting Xie, Guanzhao Liang, Xue Kong, Clement K. M. Tsui 等 2025-04-28 置信度 0.78 EpidemiologyChinaBiologyAntifungalResistance (ecology)
• Current Status of Cancer Genomics and Imaging Phenotypes: What Radiologists Need to Know
  Ongoing discoveries in cancer genomics and epigenomics have revolutionized clinical oncology and precision health care. This knowledge provides unprecedented insights into tumor biology and heterogeneity within a single tumor, among primary and metastatic lesi…
  openalex Eva Serrão, Maximiliano Klug, Brian Moloney, Aaditeya Jhaveri 等 2023-11-01 置信度 0.82 RadiogenomicsMedicineGenomicsPrecision medicineEpigenomics
• Longitudinal population-level HIV epidemiologic and genomic surveillance highlights growing gender disparity of HIV transmission in Uganda
  HIV incidence in eastern and southern Africa has historically been concentrated among girls and women aged 15-24 years. As new cases decline with HIV interventions, population-level infection dynamics may shift by age and gender. Here, we integrated population…
  openalex Mélodie Monod, Andrea Brizzi, Ronald M. Galiwango, Robert Ssekubugu 等 2023-12-05 置信度 0.82 Incidence (geometry)Transmission (telecommunications)DemographyMedicinePopulation
• Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice1
  1,25-Dihydroxyvitamin D3 plays a major role in intestinal calcium transport. To determine what phenotypic abnormalities observed in vitamin D receptor (VDR)-ablated mice are secondary to impaired intestinal calcium absorption rather than receptor deficiency, m…
  openalex Yan Chun Li, Michael Amling, Alison E. Pirro, Matthias Priemel 等 1998-10-01 置信度 0.74 Calcitriol receptorEndocrinologyInternal medicineOsteomalaciaRickets
• Characterization of pDJA1, a cardiac-specific chaperone found by genomic profiling of the post-ischemic swine heart
  BACKGROUND: Previously, we showed by subtractive hybridization in a swine model of ischemia/reperfusion that an upregulation of genes participating in mechanisms of cell survival is a potential genomic mechanism to tilt the balance from necrosis to functional …
  openalex C. Depre, Lu Wang, J TOMLINSON, Vinciane Gaussin 等 2003-04-01 置信度 0.78 Suppression subtractive hybridizationMyocyteVentricleEndocardiumBiology
• Genomic and proteomic analysis of transcription factor TFII-I reveals insight into the response to cellular stress
  The ubiquitously expressed transcription factor TFII-I exerts both positive and negative effects on transcription. Using biotinylation tagging technology and high-throughput sequencing, we determined sites of chromatin interactions for TFII-I in the human eryt…
  openalex Alex Xiu‐Cheng Fan, Giorgio L. Papadopoulos, Mir Ahamed Hossain, I‐Ju Lin 等 2014-05-29 置信度 0.80 BiologyTranscription factorTranscription (linguistics)Molecular biologyATF3
• How Do Cold-Adapted Plants Respond to Climatic Cycles? Interglacial Expansion Explains Current Distribution and Genomic Diversity in Primula farinosa L.
  Understanding the effects of past climatic fluctuations on the distribution and population-size dynamics of cold-adapted species is essential for predicting their responses to ongoing global climate change. In spite of the heterogeneity of cold-adapted species…
  openalex Spyros Theodoridis, Christophe F. Randin, Péter Szövényi, Florian C. Boucher 等 2016-12-14 置信度 0.80 InterglacialBiologyClimate changeEcologyPopulation
• A genomic history of the North Pontic Region from the Neolithic to the Bronze Age
  The North Pontic Region was the meeting point of the farmers of Old Europe and the foragers and pastoralists of the Eurasian steppe1,2, and the source of migrations deep into Europe3–5. Here we report genome-wide data from 81 prehistoric North Pontic individua…
  openalex Alexey G. Nikitin, Iosif Lazaridis, Nick Patterson, Світлана Іванова 等 2025-02-05 置信度 0.84 Bronze AgeBronzeArchaeologyAncient historyGeography
• Functional and genomic analyses of plant growth promoting traits in Priestia aryabhattai and Paenibacillus sp. isolates from tomato rhizosphere
  This study investigated plant growth-promoting (PGP) mechanisms in Priestia aryabhattai VMYP6 and Paenibacillus sp. VMY10, isolated from tomato roots. Their genomes were initially assessed in silico through various approaches, and these observations were then …
  openalex Carolina Almirón, Tomás Denis Petitti, María Agustina Ponso, Ana María Romero 等 2025-01-28 置信度 0.84 RhizosphereBiologyPaenibacillusBotanyPlant growth
• Genomic Profiling to Contextualize the Results of Intervention for Smoldering Multiple Myeloma
  PURPOSE: Early intervention for high-risk smoldering multiple myeloma (HR-SMM) achieves deep and prolonged responses. It is unclear if beneficial outcomes are due to the treatment of less complex, susceptible disease or inaccuracy in clinical definition of cas…
  openalex Dickran Kazandjian, Benjamin Diamond, Marios Papadimitriou, Elizabeth Hill 等 2024-04-23 置信度 0.84 Multiple myelomaProfiling (computer programming)BiologyMedicineComputational biology
• Integrating Genomics, Radiomics, and Pathomics in Oncology: A Scoping Review and a Framework for AI-Enabled Surgomics
  BACKGROUND: Multimodal AI integration across genomics, radiomics, and pathomics is rapidly evolving in oncology, but evidence remains heterogeneous and unevenly distributed across modalities. OBJECTIVE: To map empirical studies integrating two or more -omic mo…
  openalex Selma Mtoor, Niki Rashidian, Nouredin Messaoudi, Vincent Grasso 等 2026-01-20 置信度 0.84 WorkflowProcess managementComputer scienceKnowledge managementSystems engineering
• Which Individuals To Choose To Update the Reference Population? Minimizing the Loss of Genetic Diversity in Animal Genomic Selection Programs
  Genomic selection (GS) is commonly used in livestock and increasingly in plant breeding. Relying on phenotypes and genotypes of a reference population, GS allows performance prediction for young individuals having only genotypes. This is expected to achieve fa…
  openalex Sonia E Eynard, Pascal Croiseau, Dénis Laloë, Sébastien Fritz 等 2017-11-14 置信度 0.80 PopulationGenetic diversitySelection (genetic algorithm)Genetic gainTrait
• Cloning of Mouse Type VII Collagen Reveals Evolutionary Conservation of Functional Protein Domains and Genomic Organization
  openalex Sirpa Kivirikko, Sirpa Kehua Li, Angela M. Christiano, Jouni Uitto 1996-06-01 置信度 0.60 Anchoring fibrilsExonBiologyGeneIntron
• Widespread Discordance of Gene Trees with Species Tree in Drosophila: Evidence for Incomplete Lineage Sorting
  The phylogenetic relationship of the now fully sequenced species Drosophila erecta and D. yakuba with respect to the D. melanogaster species complex has been a subject of controversy. All three possible groupings of the species have been reported in the past, …
  openalex Daniel A. Pollard, Venky N. Iyer, Alan M Moses, Michael B. Eisen 2006-10-25 置信度 0.78 Coalescent theoryBiologyPhylogenetic treeLineage (genetic)Evolutionary biology
• Insights into ecology, pathogenesis, and biofilm formation of Enterococcus faecalis from functional genomics
  SUMMARY Enterococcus faecalis is a significant resident of the gastrointestinal tract of most animals, including humans. Although generally non-pathogenic in healthy hosts, this microbe is adept at the exploitation of compromises in host immune functions, resu…
  openalex Julia L. E. Willett, Gary M. Dunny 2024-12-23 置信度 0.84 BiologyEnterococcus faecalisOrganismModel organismGenomics
• Evolving concepts in meningioma management in the era of genomics
  Meningioma is the most common type of primary brain tumor. Surgical resection followed by surveillance is the first-line treatment for the majority of symptomatic meningiomas; however, recent advances in molecular sequencing, DNA methylation, proteomics, and s…
  openalex Annie L. Hsieh, Wenya Linda Bi, Vijaya Ramesh, Priscilla K. Brastianos 等 2024-05-16 置信度 0.84 MedicineMeningiomaGenomicsDNA methylationDNA sequencing
• Outcomes of 4 years of molecular genetic diagnosis on a panel of genes involved in premature aging syndromes, including laminopathies and related disorders
  BACKGROUND: Segmental progeroid syndromes are a heterogeneous group of rare and often severe genetic disorders that have been studied since the twentieth century. These progeroid syndromes are defined as segmental because only some of the features observed dur…
  openalex Maude Grelet, Véronique Blanck, Sabine Sigaudy, Nicole Philip 等 2019-12-01 置信度 0.82 Human geneticsPremature agingGeneGeneticsMedicine
• Satellite DNA Genomics: The Ongoing Story
  Tandemly repeated non-coding sequences, widely known as satellite DNAs (satDNAs), are extremely diverse and highly variable components of eukaryotic genomes. In recent years, advances in high-throughput sequencing and new bioinformatics platforms have enabled …
  openalex Manuel A. Garrido-Ramos, Miroslav Plohl, Eva Šatović 2025-11-22 置信度 0.84 HeterochromatinTandem repeatBiologyComputational biologySatellite DNA
• Novel Highly Pathogenic Avian Influenza A(H5N1) Virus, Argentina, 2025
  Genomic sequencing of reemerging highly pathogenic avian influenza A(H5N1) virus detected in Argentina in February 2025 revealed novel triple-reassortant viruses containing gene segments from Eurasian H5N1 and low pathogenicity viruses from South and North Ame…
  openalex Ralph Eric Thijl Vanstreels, Martha I. Nelson, Carolina Artuso, Vanina Daniela Marchione 等 2025-12-01 置信度 0.82 Influenza A virus subtype H5N1Highly pathogenicBiologyCladeVirology
• Voluntary workplace genomic testing: wellness benefit or Pandora’s box?
  Consumer interest in genetic and genomic testing is growing rapidly, with more than 26 million Americans having purchased direct-to-consumer genetic testing services. Capitalizing on the increasing comfort of consumers with genetic testing outside the clinical…
  openalex Kunal Sanghavi, Betty Cohn, Anya E. R. Prince, W Feero 等 2022-01-20 置信度 0.82 Genetic testingAppealBusinessCorporate governanceMarketing
• Genomic perspectives on foodborne illness
  Whole-genome sequencing of bacterial pathogens is used by public health agencies to link cases of food poisoning caused by the same source of contamination. The vast majority of these appear to be sporadic cases associated with small contamination episodes and…
  openalex David J. Lipman, Joshua L. Cherry, Strain Errol, Richa Agarwala 等 2024-11-05 置信度 0.84 SalmonellaCampylobacterContaminationBiologyContaminated food
• The clinical outcomes and genomic landscapes of acute lymphoblastic leukemia patients with E2A‐PBX1 : A 10‐year retrospective study
  The clinical outcomes and genomic features of E2A-PBX1 (TCF3-PBX1)-positive B-cell acute lymphoblastic leukemia (B-ALL) patients remain unclear. A total of 137 patients carrying E2A-PBX1 among 3164 B-ALL patients between 2009 and 2019 were retrospectively anal…
  openalex Biqi Zhou, Xinran Chu, Hong Tian, Tianhui Liu 等 2021-08-18 置信度 0.82 Lymphoblastic LeukemiaMedicineRetrospective cohort studyOncologyInternal medicine
• Perspective on recent developments and challenges in regulatory and systems genomics
  : Predicting how genetic variation affects phenotypic outcomes at the organismal, cellular, and molecular levels requires deciphering the cis-regulatory code, the sequence rules by which non-coding regions regulate genes. In this perspective, we discuss recent…
  openalex Julia Zeitlinger, Sushmita Roy, Ferhat Ay, Anthony Mathelier 等 2024-12-26 置信度 0.84 GenomicsBenchmarkingComputational biologyRegulatory sequenceGene regulatory network
• ULTRA-effective labeling of tandem repeats in genomic sequence
  Abstract In the age of long read sequencing, genomics researchers now have access to accurate repetitive DNA sequence (including satellites) that, due to the limitations of short read-sequencing, could previously be observed only as unmappable fragments. Tools…
  openalex Daniel R. Olson, Travis J. Wheeler 2024-01-01 置信度 0.84 Tandem repeatSequence (biology)Computational biologyVariable number tandem repeatGenetics
• BioGPT: A Generative Transformer-Based Framework for Personalized Genomic Medicine and Rare Disease Diagnosis
  This paper introduces BioGPT, a generative transformer-based framework designed to advance personalized genomic medicine and rare disease diagnosis. Unlike conventional models that process either genomic sequences or clinical narratives in isolation, BioGPT em…
  openalex Ghada Al-Kateb, Emine Cengiz, Murat Gök 2025-07-11 置信度 0.84 Generative grammarPersonalized medicineTransformerGenomic medicineComputer science
• Optimising Sampling Design for Landscape Genomics
  Landscape genomic approaches for detecting genotype-environment associations (GEA), isolation by distance (IBD) and isolation by environment (IBE) have seen a dramatic increase in use, but there have been few thorough analyses of the influence of sampling stra…
  openalex Anusha P. Bishop, Drew E. Terasaki Hart, Ian Wang 2024-12-17 置信度 0.84 Sampling (signal processing)BiologyTransectIsolation by distanceGenomics
• Data reuse in agricultural genomics research: challenges and recommendations
  The scientific community has long benefited from the opportunities provided by data reuse. Recognizing the need to identify the challenges and bottlenecks to reuse in the agricultural research community and propose solutions for them, the data reuse working gr…
  openalex Alenka Hafner, Victoria L. DeLeo, Cecilia Deng, Christine G. Elsik 等 2025-01-01 置信度 0.84 GenomicsData scienceReuseAgricultureComputer science
• Cell cycle regulation of the human cdc2 gene.
  openalex Stephen Dalton 1992-05-01 置信度 0.67 BiologyCyclin-dependent kinase 1E2FGeneTranscription (linguistics)
• Expanding the genomic diversity of human anelloviruses
  Abstract Anelloviruses are a group of small, circular, single-stranded DNA viruses that are found ubiquitously across mammalian hosts. Here, we explored a large number of publicly available human microbiome datasets and retrieved a total of 829 anellovirus gen…
  openalex Sejal Modha, Joseph Hughes, Richard Orton, Spyros Lytras 2025-01-01 置信度 0.84 BiologyGenomeRecombinationHomologous recombinationGenetics
• Genos: a human-centric genomic foundation model
  BACKGROUND: The rapid expansion of human genomic data demands foundation models that manage ultra-long sequences and capture population diversity, limitations common in existing models that lack human-specific representation, and clinical inference efficiency.…
  openalex Anqi Lin, Bin Xie, Ye Cheng, Cheng Wang 等 2025-01-01 置信度 0.84 BlueprintDocumentationFoundation (evidence)Benchmark (surveying)Computer science
• Precision Neuro-Oncology in Glioblastoma: AI-Guided CRISPR Editing and Real-Time Multi-Omics for Genomic Brain Surgery
  Precision neurosurgery is rapidly evolving as a medical specialty by merging genomic medicine, multi-omics technologies, and artificial intelligence (AI) technology, while at the same time, society is shifting away from the traditional, anatomic model of care …
  openalex Matei Șerban, Corneliu Toader, Răzvan-Adrian Covache-Busuioc 2025-07-30 置信度 0.84 Precision medicineOmicsGenomicsPersonalized medicineComputational biology
• Triazole-resistant Aspergillus fumigatus in the Netherlands between 1994 and 2022: a genomic and phenotypic study
  Background Aspergillus fumigatus is the main cause of invasive aspergillosis and triazole antifungals are the primary treatment option. The effectiveness of triazole therapy is hampered by the emergence of resistance, mainly caused by mutations in the cyp51A g…
  openalex Yinggai Song, Jochem B. Buil, Johanna Rhodes, Jan Zoll 等 2025-07-15 置信度 0.84 Aspergillus fumigatusGenotypeBiologyMicrobiologyTriazole
• Origins of chromosome instability unveiled by coupled imaging and genomics
  , the underlying processes and rates of spontaneous CA formation in human cells are underexplored. Here we introduce machine-learning-assisted genomics and imaging convergence (MAGIC)-an autonomously operated platform that integrates live-cell imaging of micro…
  openalex Marco Raffaele Cosenza, Alice Gaiatto, Büşra Erarslan Uysal, Álvaro Andrades 等 2025-10-29 置信度 0.84 Dicentric chromosomeBiologyGenome instabilityChromosomeSomatic cell
• The effects of amino acid substitution of spike protein and genomic recombination on the evolution of SARS-CoV-2
  Over three years' pandemic of 2019 novel coronavirus disease (COVID-19), multiple variants and novel subvariants have emerged successively, outcompeted earlier variants and become predominant. The sequential emergence of variants reflects the evolutionary proc…
  openalex Letian Fang, Jie Xu, Yue Zhao, Junyan Fan 等 2023-07-25 置信度 0.78 BiologyAntigenicityGeneticsVirologyMutation
• A non-canonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML
  RNA-binding proteins (RBPs) form a large and diverse class of factors, many members of which are overexpressed in hematologic malignancies. RBPs participate in various processes of messenger RNA (mRNA) metabolism and prevent harmful DNA:RNA hybrids or R-loops.…
  openalex Shiva Bamezai, Alex Jose Pulikkottil, Tribhuwan Yadav, Vegi M. Naidu 等 2023-05-05 置信度 0.82 BiologyMyeloid leukemiaHaematopoiesisStem cellProgenitor cell
• Characterization of genomic structures and expression profiles of three tandem repeats of a mouse double homeobox gene: Duxbl
  We identified and cloned a mouse double homeobox gene (Duxbl), which encodes two homeodomains. Duxbl gene, a tandem triplicate produces two major transcripts, Duxbl and Duxbl-s. The amino acid sequences of Duxbl homeodomains are most similar to those of human …
  openalex Shey‐Lin Wu, Ming‐Shiun Tsai, Swee‐Hee Wong, Hsiu‐Mei Hsieh‐Li 等 2010-01-08 置信度 0.78 BiologyMyogenesisHomeoboxMyogeninC2C12
• Human metapneumovirus (hMPV) in 2025: emerging trends and insights from community and hospital-based respiratory panel analyses—a comprehensive review
  Human metapneumovirus (hMPV) is a significant respiratory pathogen, primarily impacting young, elderly, and immunocompromised populations. While the clinical presentations are similar to those of other respiratory viruses such as respiratory syncytial virus (R…
  openalex Keyhan Mohammadi, Samireh Faramarzi, Shakila Yaribash, Zahra Valizadeh 等 2025-05-20 置信度 0.84 Human metapneumovirusMetapneumovirusVirologyBiologyRespiratory system
• Non-geneticist champions are essential to the mainstreaming of genomic medicine
  Demand for genomic testing is increasing across medicine as it paves the way for earlier diagnoses and targeted management of patients with rare diseases. The diagnostic utility of genomic testing has been clearly established, with evidence demonstrating value…
  openalex Michael P. Mackley, Emma Weisz, Robin Z. Hayeems, Clara Gaff 等 2025-01-03 置信度 0.84 GeneticistGenomic medicineHuman geneticsMainstreamingGenetics
• Genomic analysis of 116 autism families strengthens known risk genes and highlights promising candidates
  Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a strong genetic component in which rare variants contribute significantly to risk. We performed whole genome and/or exome sequencing (WGS and WES) and SNP-array analysis to identify…
  openalex Marta Viggiano, Fabiola Ceroni, Paola Visconti, Annio Posar 等 2024-03-22 置信度 0.84 GeneticsCopy-number variationPenetranceBiologyCandidate gene
• TIN2, a new regulator of telomere length in human cells
  openalex Sahn-Ho Kim, Patrick Kaminker, Judith Campisi 1999-12-01 置信度 0.64 TelomereBiologyShelterinTelomeraseTelomere-binding protein
• Functional impact of global rare copy number variation in autism spectrum disorders
  openalex Dalila Pinto, Alistair T. Pagnamenta, Lambertus Klei, Richard Anney 等 2010-06-08 置信度 0.60 Copy-number variationAutismGeneticsBiologyGenome
• Genomics in Epidemiology and Disease Surveillance: An Exploratory Analysis
  Genomics has revolutionized epidemiology and disease surveillance by providing powerful tools for identifying, tracking, and analyzing pathogens at the molecular level. This exploratory analysis examines the integration of genomic with traditional epidemiologi…
  openalex Shraddha Tiwari, Thakur Dhakal, Baek-Jun Kim, Gab‐Sue Jang 等 2025-12-01 置信度 0.84 GenomicsOutbreakDiseaseInfectious disease (medical specialty)Epidemiology
• Genomic evolution of influenza during the 2023–2024 season, the johns hopkins health system
  Influenza, a human disease caused by viruses in the Orthomyxoviridae family, is estimated to infect 5% -10 % of adults and 20% -30 % of children annually. Influenza A (IAV) and Influenza B (IBV) viruses accumulate amino acid substitutions (AAS) in the hemagglu…
  openalex Madeline Yunker, David A. Villafuerte, Amary Fall, Julie M. Norton 等 2024-07-26 置信度 0.84 GerontologyBiologyMedicine
• Metabolic Engineering of Terpenoid Biosynthesis in Medicinal Plants: From Genomic Insights to Biotechnological Applications
  Terpenoids, which are essential pharmaceutical compounds, encounter significant production challenges due to their low yields in native plants and associated ecological concerns. This review summarizes recent advances in metabolic engineering strategies applie…
  openalex Changfeng Guo, Si Xu, Xiaoyun Guo 2025-09-05 置信度 0.84 Metabolic engineeringTerpenoidBiosynthesisBiotechnologyBiology
• Analysis of Association between Vitamin D Deficiency and Insulin Resistance
  Recent evidence revealed extra skeleton activity of vitamin D, including prevention from cardiometabolic diseases and cancer development as well as anti-inflammatory properties. It is worth noting that vitamin D deficiency is very common and may be associated …
  openalex Izabela Szymczak-Pajor, Agnieszka Śliwińska 2019-04-06 置信度 0.82 Insulin resistanceMedicinevitamin D deficiencyInsulinEndocrinology
• Codon usage patterns and genomic variation analysis of chloroplast genomes provides new insights into the evolution of Aroideae
  Aroideae is an important subfamily of the Araceae family and contains many plants with medicinal and edible value. It is difficult to identify and classify Aroideae species accurately on the basis of morphology alone because of their polymorphic phenotypic tra…
  openalex Xinbi Jia, Jiaqi Wei, Yuewen Chen, Chenghong Zeng 等 2025-02-05 置信度 0.84 Variation (astronomy)GenomeEvolutionary biologyBiologyChloroplast
• The genomic and epigenomic landscapes of hemizygous genes across crops with contrasting reproductive systems
  Hemizygous genes, which are present on only one of the two homologous chromosomes of diploid organisms, have been mainly studied in the context of sex chromosomes and sex-linked genes. However, these genes can also occur on the autosomes of diploid plants due …
  openalex Yanling Peng, Yiwen Wang, Yuting Liu, Xinyue Fang 等 2025-02-07 置信度 0.84 BiologyGeneticsGeneGenomeAutosome
• Genomic and phenomic prediction for soybean seed yield, protein, and oil
  Developments in genomics and phenomics have provided valuable tools for use in cultivar development. Genomic prediction (GP) has been used in commercial soybean [Glycine max L. (Merr.)] breeding programs to predict grain yield and seed composition traits. Phen…
  openalex Liza Van der Laan, Kyle Parmley, Mojdeh Saadati, Hernan Torres Pacin 等 2025-02-19 置信度 0.84 PhenomicsBiologyBest linear unbiased predictionGrowing seasonGenome-wide association study
• The socio-economic factors affecting the emergence and impacts of new genomic techniques in agriculture: A scoping review
  The development of new genomic techniques (NGTs) has the potential to address some future challenges related to food security, agroecology and global warming. NGTs encompass ZFN-1, ZFN-2 and ZFN-3 technologies, TALENs, Meganucleases, CRISPR-Cas, and Oligonucle…
  openalex Stephane Lemarié, Stéphan Marette 2022-07-30 置信度 0.82 Food securityAgricultureIntellectual propertyBusinessPolitical science
• Mapping MAVE data for use in human genomics applications
  BACKGROUND: Experimental data from functional assays have a critical role in interpreting the impact of genetic variants. Assay data must be unambiguously mapped to a reference genome to make it accessible, but it is often reported relative to assay-specific s…
  openalex Jeremy A. Arbesfeld, Estelle Y. Da, James Stevenson, Kori Kuzma 等 2025-06-25 置信度 0.84 EnsemblGenomicsDECIPHERPersonal genomicsComputational biology
• Driving Global Health equity and precision medicine through African genomic data
  Significant gaps persist despite the progress in raising awareness of genomic diversity and including individuals of African ancestry in genomic research. African populations remain underrepresented in genomic studies despite their deep evolutionary history, d…
  openalex Oyesola Ojewunmi, Segun Fatumo 2025-04-30 置信度 0.84 BiologyPrecision medicineBiobankHealth equityGenomic medicine
• Deep learning-driven survival prediction in pan-cancer studies by integrating multimodal histology-genomic data
  Accurate cancer prognosis is essential for personalized clinical management, guiding treatment strategies and predicting patient survival. Conventional methods, which depend on the subjective evaluation of histopathological features, exhibit significant inter-…
  openalex Yongfei Hu, Xinyu Li, Ying Yi, Yan Huang 等 2025-03-01 置信度 0.84 Artificial intelligenceDeep learningCancerComputer scienceMultimodal therapy
• Draft genome of a commonly misdiagnosed multidrug resistant pathogen Candida auris
  BACKGROUND: Candida auris is a multidrug resistant, emerging agent of fungemia in humans. Its actual global distribution remains obscure as the current commercial methods of clinical diagnosis misidentify it as C. haemulonii. Here we report the first draft gen…
  openalex Sharanya Chatterjee, Shuba Varshini Alampalli, Rishi Kumar Nageshan, Sivarajan T. Chettiar 等 2015-09-07 置信度 0.80 Candida aurisBiologyFungal pathogenGenomeOpportunistic pathogen
• Genomic evidence supports the “long chronology” for the peopling of Sahul
  The timing of the settlement of Sahul—the Pleistocene landmass formed by present-day New Guinea, Australia, and Tasmania that existed until ~9000 years ago (~9 ka)—remains highly contentious. The so-called “long chronology” posits the first main arrivals at ~6…
  openalex Francesca Gandini, Mafalda Almeida, M. George B. Foody, Nano Nagle 等 2025-11-28 置信度 0.84 Context (archaeology)PleistoceneLineage (genetic)Range (aeronautics)Evolutionary biology
• slendr: a framework for spatio-temporal population genomic simulations on geographic landscapes
  One of the goals of population genetics is to understand how evolutionary forces shape patterns of genetic variation over time. However, because populations evolve across both time and space, most evolutionary processes also have an important spatial component…
  openalex Martin Petr, Benjamin C. Haller, Peter L. Ralph, Fernando Racimo 2023-12-15 置信度 0.82 GeographyEvolutionary biologyPopulationCartographyComputer science
• Critical assessment of coalescent simulators in modeling recombination hotspots in genomic sequences
  BACKGROUND: Coalescent simulation is pivotal for understanding population evolutionary models and demographic histories, as well as for developing novel analytical methods for genetic association studies for DNA sequence data. A plethora of coalescent simulato…
  openalex Tao Yang, Hong‐Wen Deng, Tianhua Niu 2014-01-03 置信度 0.80 Coalescent theoryComputational biologyRecombinationDNA microarrayBiology
• A Genomic Surveillance Circuit for Emerging Viral Pathogens
  Genomic surveillance has been crucial in monitoring the evolution and spread of SARS-CoV-2. In Andalusia (Spain), a coordinated genomic surveillance circuit was established to systematically sequence and analyze viral genomes across the region. This initiative…
  openalex Carlos S. Casimiro‐Soriguer, Marí­a Pí­a Lara, Andrea Aguado, Carlos Loucera 等 2025-04-16 置信度 0.84 GenomePreparednessComputational biologyPublic health surveillanceIdentification (biology)
• Integrative Genomics and Precision Breeding for Stress-Resilient Cotton: Recent Advances and Prospects
  Developing climate-resilient and high-quality cotton cultivars remains an urgent challenge, as the key target traits yield, fibre properties, and stress tolerance are highly polygenic and strongly influenced by genotype–environment interactions. Recent advance…
  openalex Zahra Ghorbanzadeh, Bahman Panahi, Leila Purhang, Zhila Hossein Panahi 等 2025-10-15 置信度 0.84 IdeotypeGenomicsBiologyGenomic selectionBiotechnology
• RepeatsDB in 2025: expanding annotations of structured tandem repeats proteins on AlphaFoldDB
  RepeatsDB (URL: https://repeatsdb.org) stands as a key resource for the classification and annotation of Structured Tandem Repeat Proteins (STRPs), incorporating data from both the Protein Data Bank (PDB) and AlphaFoldDB. This latest release features substanti…
  openalex Damiano Clementel, Paula Nazarena Arrías, Soroush Mozaffari, Zarifa Osmanli 等 2024-10-11 置信度 0.84 AnnotationBiologyKey (lock)Tandem repeatInterface (matter)
• Genomic driven factors enhance biocatalyst-related cellulolysis potential in anaerobic digestion
  openalex Huichuan Zhuang, Po‐Heng Lee, Zhuoying Wu, Houde Jing 等 2021-04-19 置信度 0.68 CellulosomeCellulosic ethanolBiomass (ecology)BioenergyCellulose
• Integrative multi-environmental genomic prediction in apple
  Genomic prediction for multiple environments can aid the selection of genotypes suited to specific soil and climate conditions. Methodological advances allow effective integration of phenotypic, genomic (additive, nonadditive), and large-scale environmental (e…
  openalex Michaela Jung, Carles Quesada‐Traver, Morgane Roth, María José Aranzana 等 2024-11-20 置信度 0.84 BiologyBiotechnologyComputational biology
• Linezolid in the Focus of Antimicrobial Resistance of Enterococcus Species: A Global Overview of Genomic Studies
  Linezolid (LNZ) is a synthetic oxazolidinone antibiotic that inhibits bacterial protein synthesis through binding to ribosomal RNA, also preventing the assembly of the initiation complex during translation. It is one of the last-line therapeutic options for se…
  openalex Slavil Peykov, Boris Kirov, Tanya Strateva 2025-08-24 置信度 0.84 LinezolidAntimicrobialEnterococcusAntibiotic resistanceBiology
• Two patients walk into a clinic...a genomics perspective on the future of schizophrenia
  Progress is being made in schizophrenia genomics, suggesting that this complex brain disorder involves rare, moderate to high-risk mutations and the cumulative impact of small genetic effects, coupled with environmental factors. The genetic heterogeneity under…
  openalex Aiden Corvin 2011-11-08 置信度 0.80 Schizophrenia (object-oriented programming)GenomicsBiologyPerspective (graphical)Disease
• Driver pattern identification over the gene co-expression of drug response in ovarian cancer by integrating high throughput genomics data
  Multiple types of high throughput genomics data create a potential opportunity to identify driver patterns in ovarian cancer, which will acquire some novel and clinical biomarkers for appropriate diagnosis and treatment to cancer patients. To identify candidat…
  openalex Xinguo Lu, Jibo Lu, Bo Liao, Xing Li 等 2017-11-17 置信度 0.80 Computational biologyMutationCandidate geneGenomicsBiology
• The Consortium for Genomic Diversity, Ancestry, and Health in Colombia (CÓDIGO): building local capacity in genomics and bioinformatics
  The Consortium for Genomic Diversity, Ancestry, and Health in Colombia (CÓDIGO) aims to build a community of Colombian researchers in support of local capacity in genomics, bioinformatics, and precision health. Here, we present the first CÓDIGO data release an…
  openalex Leonardo Mariño‐Ramírez, Shivam Sharma, James Matthew Hamilton, T. Nguyen 等 2025-07-17 置信度 0.84 Genetic genealogyGeneticsGenomicsBiologyGenome
• Genomic conflicts and sexual antagonism in human health: insights from oxytocin and testosterone
  We review the hypothesized and observed effects of two of the major forms of genomic conflicts, genomic imprinting and sexual antagonism, on human health. We focus on phenotypes mediated by peptide and steroid hormones (especially oxytocin and testosterone) be…
  openalex Mikael Mökkönen, Bernard J. Crespi 2015-01-09 置信度 0.80 BiologyAntagonismTestosterone (patch)OxytocinGenetics
• Unraveling the genomic diversity and admixture history of captive tigers in the United States
  Genomic studies of endangered species have primarily focused on describing diversity patterns and resolving phylogenetic relationships, with the overarching goal of informing conservation efforts. However, few studies have investigated genomic diversity housed…
  openalex Ellie E. Armstrong, Jazlyn A. Mooney, Katherine A. Solari, Bernard Kim 等 2024-09-19 置信度 0.84 SubspeciesTigerBiologyInbreedingGenetic diversity
• Sucralose: A Review of Environmental, Oxidative and Genomic Stress
  This review explores current knowledge on the environmental, oxidative, and genomic effects of sucralose (E955), an artificial sweetener widely used in food products, including those for children, and known to cross both the placental barrier and into breast m…
  openalex Volodymyr Tkach, Тетяна Морозова, Isabel Gaivão, Natasha Gomes de Miranda 等 2025-07-01 置信度 0.84 SucraloseAquatic ecosystemOxidative stressBiologyBiotechnology
• CRISPR-Cas systems as next-generation antimicrobials: a systemic review of mechanisms, delivery strategies, and translational challenges.
  Introduction The rapid global increase in multidrug-resistant (MDR) bacteria has compromised the effectiveness of conventional antibiotics, stressing the urgent need for alternative antimicrobial strategies. CRISPR-Cas systems, originally evolved as bacterial …
  europepmc 2026 置信度 0.87
• Bridging science and hope: the evolving story of gene therapy for neuromuscular diseases.
  The field of gene therapy for neuromuscular dystrophies has evolved over the past two decades. Despite some outstanding positive outcomes, some unfortunate adverse effects also led to big setbacks. One important key point is to study relevant preclinical model…
  europepmc 2026 置信度 0.87
• Modern genomic and omics-based technologies for millet breeding and genetic improvement.
  Millets are a diverse group of small seeded grasses that have long served as vital staple foods and forage crops across a wide range of agro-ecological regions. Known for their exceptional adaptability to marginal and resource poor environments, millets have h…
  europepmc 2026 置信度 0.87
• The Journey of Gene Therapy in Sickle Cell Disease: How Molecular Advances Meet Clinical Care.
  Sickle cell disease (SCD) is a monogenic disorder responsible for recurrent vaso-occlusive crises, progressive organ damage, and shortened life expectancy. For decades, allogeneic hematopoietic stem cell transplantation from a matched sibling donor has been th…
  europepmc 2026 置信度 0.87
• Improving iSpyMacCas9 multiplex genome editing in rice by CRISPR-combo-mediated BBM1 activation.
  The recently developed CRISPR-Combo technology enables simultaneous targeted mutagenesis and transcriptional activation in plants. However, its reliance on SpCas9 limits its use at AT-rich genomic loci, such as promoter regions commonly targeted for transcript…
  europepmc 2026 置信度 0.87
• The epigenetic landscape of heterosis: integrating multi-layer regulatory insights and navigating the path to causality.
  In some crosses, the hybrid progeny perform better than their parental inbred lines in terms of beneficial traits (e.g., greater biomass, faster development), a phenomenon known as hybrid vigor or heterosis. While classical genetic paradigms explain much of it…
  europepmc 2026 置信度 0.87
• [Research progress of the CRISPR-Cas system in the detection and elimination of antibiotic resistance genes].
  The abuse of antibiotics has led to increasingly severe antibiotic resistance, which poses a serious threat to global public health security. Therefore, the rapid detection and effective elimination of antibiotic resistance genes are crucial for controlling th…
  europepmc 2026 置信度 0.87
• Application of Gene Editing Technology in Poultry.
  Gene editing technology, a revolutionary tool in molecular biology, enables precise modifications of genomic sequences and gene expression patterns, thereby conferring desired traits to cells or organisms. Since 2014, CRISPR/Cas9 has rapidly become the most wi…
  europepmc 2026 置信度 0.87
• Heat-induced mutator: DNA repair polymerase Polλ shapes mutation under heat.
  europepmc 2026 置信度 0.72
• Gene Editing Strategies for Duchenne Muscular Dystrophy: From Molecular Mechanisms to Clinical Translation.
  Duchenne muscular dystrophy (DMD) remains a major challenge in genetic medicine due to the difficulty of achieving durable, body-wide restoration of dystrophin in post-mitotic muscle tissues. Although current therapies-including exon skipping and micro-dystrop…
  europepmc 2026 置信度 0.87
• Commentary: CRISPR-Cas9 mediated editing of starch branching enzyme, SBE2 gene in potato for enhanced resistant starch for health benefits.
  The global burden of diet-related metabolic disorders has intensified efforts to improve the nutritional quality of staple crops. Potatoes, a dietary cornerstone for millions, present a particular challenge due to their high glycemic index, primarily attributa…
  europepmc 2026 置信度 0.87
• DMT1 regulates systemic trace metal handling and developmental outcomes: Insights from targeted mutagenesis in zebrafish.
  Divalent metal transporter 1 (DMT1) is thought to be the primary route for non-heme iron absorption in vertebrates, but its systemic role remains poorly understood. Using CRISPR-Cas9 gene editing, we generated a DMT1 knockout (dmt1 -/- ; KO) zebrafish mutant l…
  europepmc 2026 置信度 0.87
• Harnessing CRISPR-Cas Technology for Precision Antimicrobial Targeting.
  Introduction Antibiotics have made major contributions to medicine, but misuse has resulted in antimicrobial resistance (AMR), which is caused by organisms such as ESKAPE and poses a danger to world health, which can potentially claim many more lives by 2050. …
  europepmc 2026 置信度 0.87
• Transgenesis and targeted mutagenesis in the human-parasitic nematode <i>Strongyloides stercoralis</i>.
  Strongyloides stercoralis is a soil-transmitted helminth that is responsible for an estimated 300-600 million human infections worldwide, mostly in impoverished areas of tropical and sub-tropical countries. To date, S. stercoralis is also the only human-parasi…
  europepmc 2026 置信度 0.87
• Negative Regulators of Rice Agronomic Traits: Functional Insights and Applications in Genome Editing-Based Breeding.
  Rice is the staple crop for more than half of the global population, and improving grain yield, grain quality, and stress resistance remain central goals of modern rice breeding. Among current precision breeding strategies, genome editing has created new oppor…
  europepmc 2026 置信度 0.94 biologycomputational biologybiotechnologyneurosciencepharmacology
• Recent Advances in the Non-viral Delivery of Genes to Central Nervous System Disorders.
  Disorders of the central nervous system (CNS), neurological disorders, neurodegenerative disorders, genetic disorders) constitute a significant burden on global health, and current treatment options remain challenging. As treatment for CNS disorders is primari…
  europepmc 2026 置信度 0.87
• AlphaFold3-guided tracrRNA redesign yields small monomeric Cas12f RNPs.
  Although Cas12f (Cas14) is among the smallest Class 2 CRISPR (clustered regularly interspaced short palindromic repeats) effectors, it assembles into dimeric ribonucleoprotein (RNP) complexes with guide RNA, substantially increasing its functional size and lim…
  europepmc 2026 置信度 0.87
• Plant responses to cold stress: molecular and physiological adaptive mechanisms with breeding advances.
  Cold stress is a critical bottleneck that constrains crop cultivation boundaries, reshapes species distribution patterns, and limits yield improvement, directly threatening plant survival and growth. This review systematically analyzes the impacts of cold stre…
  europepmc 2026 置信度 0.87
• Research progress and applications of gene activation editing technology in crops.
  In recent years, CRISPR/Cas gene editing technology has become a fundamental method in biological breeding. As a vital tool for overcoming technological obstacles, it is currently widely used in functional gene research and genetic enhancement across a variety…
  europepmc 2026 置信度 0.87
• Multiplex gene editing drives revolution in crop breeding: overlaid editing of multiple genes and customization of complex traits.
  Modern agriculture currently demands higher standards for the simultaneous improvement of crop yield, quality and stress resistance. However, traditional crop breeding methods can no longer meet the needs of modern agricultural development. Improving a single …
  europepmc 2026 置信度 0.87
• Compact Cas12f enables genome editing in avian cells.
  Precise genome editing in avian species has been constrained by the low delivery efficiency of conventional CRISPR nucleases, such as Cas9 and Cas12a, due to their large molecular sizes. Cas12f (also known as Cas14), a compact CRISPR nuclease, has emerged as a…
  europepmc 2026 置信度 0.87
• CRISPR/Cas Genome Editing and Its Applications in Cereal Crop Improvement.
  CRISPR/Cas-based genome editing has emerged as a transformative tool for precise genetic improvement of cereal crops. Recent advances in CRISPR technologies, including Cas9, Cas12, Cas13, base editing, and prime editing, have enabled targeted modification of g…
  europepmc 2026 置信度 0.87
• CRISPR-Cas9 Therapeutics in Early Clinical Development: Delivery and Molecular Diagnostics.
  CRISPR-Cas9 has progressed from an experimental tool to a therapeutic modality, marked by the first regulatory approvals of an ex vivo-edited autologous CD34+ hematopoietic stem cell product that induces fetal hemoglobin (CASGEVY/exa-cel). In this narrative re…
  europepmc 2026 置信度 0.87
• Genome editing between wonder and rejection.
  acceptance. Other jurisdictions have adopted more product-based or case-by-case approaches, placing greater emphasis on proportionality, familiarity, and characteristics of the final product (Casacuberta and Puigdomènech, 2018;Gould et al., 2022). Consequently…
  europepmc 2026 置信度 0.87
• A CRISPR workshop series for diverse learners in Hawai'i: design, implementation, and outcomes across 3 years.
  CRISPR genome editing has revolutionized modern biotechnology, yet access to experiential training remains limited, particularly in underrepresented and geographically isolated regions. This report describes the design, implementation, and evaluation of a CRIS…
  europepmc 2026 置信度 0.87
• Advances in the use of morphogenic regulators and peptide regenerating factors for boosting plant transformation and genome editing.
  Plant regeneration and transformation remain significant bottlenecks towards the genetic improvement of most crop species by either genome editing or transgenic approaches. Recent research has therefore, transitioned from manual optimization of culture media a…
  europepmc 2026 置信度 0.87
• Modulating the cleavage and polyadenylation site: from research tools to therapeutic opportunities.
  Almost all protein-coding and long noncoding genes that are transcribed by RNA polymerase II employ cleavage and polyadenylation (CPA) for 3' end maturation of their nascent RNAs. More than 70% of human mRNA genes display alternative polyadenylation (APA), res…
  europepmc 2026 置信度 0.87
• Advances in molecular breeding of medicinal plants.
  Medicinal plants are rich in bioactive constituents and are extensively utilized in the healthcare sector, holding significant value for both industrial and daily applications. In the context of economic development and escalating environmental challenges, the…
  europepmc 2026 置信度 0.87
• Gene-sized editing for the therapy of genetic diseases.
  Programmable genome editing technologies have reshaped the landscape of biomedical sciences, enabling the development of methods with great translational potential. CRISPR-Cas represents one of the most important and widely adopted genome editing tools, althou…
  europepmc 2026 置信度 0.87
• CRISPR-Based Therapy for Ischemic Stroke: A Narrative Review.
  Ischemic stroke (IS) is one of the most common neurological diseases worldwide and is caused by the blockage of cerebral blood vessels, leading to reduced blood flow and neuronal damage. Given the limitations of existing treatments, CRISPR gene-editing technol…
  europepmc 2026 置信度 0.87
• Loss of U11/U12 spliceosome gene <i>ZCRB1</i> leads to aberrant ciliogenesis and WNT signaling.
  The U12-dependent, or minor, spliceosome processes only 0.5% of human introns, and yet, it is known to profoundly influence gene expression and cellular signaling. The ZCRB1 protein is a core component of the U12 mono-snRNP, but its functional significance to …
  europepmc 2026 置信度 0.87
• Targeting Myostatin for Sustainable Meat Production: Insights From Multiple Species.
  Myostatin gene (MSTN), a TGF-β superfamily member, negatively regulates skeletal muscle growth, positioning it as a prime genetic target for enhancing livestock meat production. This review synthesizes evidence from 1979 to 2025 on MSTN mutations across cattle…
  europepmc 2026 置信度 0.87
• Improvement of chicken genome editing efficiency in vitro using ribonucleoprotein-mediated CRISPR/Cas9 delivery.
  Background Limitations in genome editing of avian species, including chicken, due to the inaccessibility of one-cell zygotes, have led to the manipulation of primordial germ cells (PGCs) as the primary approach for generating genetically engineered birds. Alth…
  europepmc 2026 置信度 0.87
• Human pluripotent stem cell engineering with CRISPR-Cas9 for Parkinson's disease.
  Parkinson's disease (PD) entails loss of substantia nigra dopamine (DA) neurons and α-synuclein pathology. Currently, no effective disease-modifying therapies have been developed. Human pluripotent stem cells (hPS cells) can generate DA neurons on scale, enabl…
  europepmc 2026 置信度 0.87
• Generation of a FRMD5 knockout human embryonic stem cell line by CRISPR/Cas9 editing.
  FRMD5 is a protein-coding gene on human chromosome 15q15.3 encoding a FERM domain-containing protein. Its mutations are linked to NEDEMA, a rare autosomal dominant neurodevelopmental disorder characterized by developmental delay, intellectual disability, ataxi…
  europepmc 2026 置信度 0.87
• The evolving landscape of gene editing therapies for human genetic diseases: a twenty-year bibliometric analysis.
  Background/objectives Despite the transformative potential of gene editing technologies, a systematic mapping of their translational trajectory from bench to bedside remains scarce. This bibliometric analysis aims to chart the bench-to-bedside evolution, ident…
  europepmc 2026 置信度 0.87
• Emerging trends in genome editing of wild animals.
  Globally, nearly one million species are currently threatened with extinction, highlighting the need for more efficient solutions to biological conservation. Genome editing, which allows for faster and more precise changes in genomes, is a promising technique …
  europepmc 2026 置信度 0.87
• Metabolic engineering strategies for optimized lignan production in plants.
  Plant secondary metabolites, including lignans, play essential roles in plant defense and adaptation, and their pharmacological properties are increasingly valued for human health. Lignans are dimers derived from the phenylpropanoid pathway whose biosynthesis …
  europepmc 2026 置信度 0.87
• Exploring gene editing as a potential therapeutic strategy for hemophilia.
  Hemophilia is an inherited bleeding disorder caused by mutations in the F8 or F9 gene, leading to a deficiency or dysfunction of coagulation factors VIII or IX. While current treatments, such as factor replacement, extended half-life factors, and gene therapy,…
  europepmc 2026 置信度 0.87
• Visual detection platform based on RPA-CRISPR/Cas12a for Klebsiella pneumoniae and Carbapenem-resistant Klebsiella pneumoniae in clinical and food safety settings.
  Introduction The rise of Klebsiella pneumoniae (KP) and carbapenem-resistant KP (CRKP) poses grave threats to public health and food safety, creating an urgent demand for rapid point-of-care testing (POCT). Traditional detection methods are limited by laborato…
  europepmc 2026 置信度 0.87
• Transgene-free genome editing in citrus and poplar meristem tissues via biolistic ribonucleoprotein delivery of CRISPR-Cas9.
  Key message Biolistic particle bombardment was used to deliver CRISPR-Cas9 ribonucleoprotein complexes (RNP) into the shoot apical meristem tissue of citrus and axillary meristem tissue of poplar, generating directed mutations in target genes. The use of meris…
  europepmc 2026 置信度 0.87
• Engineering next-generation crops through CRISPR-mediated horizontal gene transfer.
  Crops increasingly face overlapping stresses such as heat, drought, salinity, and pathogens that conventional breeding or genome editing rarely overcome in combination. To address this, we propose CRISPR-enabled horizontal gene transfer (CRISPR-HGT) as a progr…
  europepmc 2026 置信度 0.87
• Topical application of Cas9 ribonucleoproteins inhibits corneal neovascularization in a mouse model of alkali burn injury.
  Corneal neovascularization is a sight-threatening condition for which current treatments such as anti-VEGF agents are limited by invasiveness and side effects. We present the first non-viral, CRISPR/Cas9-based gene therapy delivered via topical eye drops that …
  europepmc 2026 置信度 0.87
• Plant microbiome engineering: from inoculation to genome editing.
  Plant-associated microbiomes are central to crop productivity, nutrient efficiency, and stress resilience, yet conventional microbiome manipulation strategies, largely based on microbial inoculation and agronomic management, often suffer from inconsistent fiel…
  europepmc 2026 置信度 0.94 biologysynthetic biologymicrobiologycomputational biologybiotechnology
• The Effector SIX8 Contributes to Virulence of Fusarium oxysporum f. sp. lactucae Race 4 on Lettuce.
  Fusarium wilt disease of lettuce caused by the soilborne fungus Fusarium oxysporum f. sp. lactucae (Fola) causes substantial crop losses worldwide. Four races of Fola have been identified with race 1 (Fola1) and the more recently emerged race 4 (Fola4) predomi…
  europepmc 2026 置信度 0.87
• Research progress on cold tolerance key genes and mechanisms in four major northern China crops.
  Global climate change poses significant challenges to agricultural production and food security, particularly in high-latitude regions such as northern China, where low temperatures, drought, and extreme weather severely affect crop growth and development. Add…
  europepmc 2026 置信度 0.83
• Detection of duck adenovirus 3 using RAA-CRISPR/Cas12a based lateral flow dipstick method.
  Duck adenovirus 3 (DAdV-3) was firstly identified in Muscovy ducklings exhibiting slight pericardial effusion, swelling, and hemorrhaging in the kidneys, which is a poorly characterized duck virus. This study established a CRISPR/Cas12a coupled with a Lateral …
  europepmc 2026 置信度 0.87
• CRISPR-Cpf1-Mediated Gene-Editing System Based on a Single Bidirectional Promoter.
  Recent advances in gene therapy have highlighted the potential of CRISPR-based gene-editing systems combined with adeno-associated virus (AAV) vectors. However, the limited packaging capacity of AAV remains a significant challenge for the simultaneous expressi…
  europepmc 2026 置信度 0.87
• Non-Viral CRISPR carriers: transient delivery with lasting effects.
  CRISPR-Cas9 has revolutionized the field of genome editing. While conventional gene supplementation therapies and the market of related gene therapy products are dominated by viral vectors, non-viral delivery strategies are increasingly being explored for in v…
  europepmc 2026 置信度 0.87
• Literature horizon scan for new scientific data on plants, microorganisms and animals, and their products obtained by new genomic techniques (October 2025).
  The European Food Safety Authority has issued several scientific opinions on plants, microorganisms and animals obtained through certain new genomic techniques (NGTs), following requests received by the European Commission. These scientific opinions provided c…
  europepmc 2026 置信度 0.83
• CRISPR-screen informed engineered T cell therapies.
  Adoptive T cell therapies can deliver curative responses for refractory patients with B cell malignancies, yet clinical activity in solid tumors remains inconsistent. Tumor-intrinsic barriers dominating this inconsistency include the immunosuppressive solid tu…
  europepmc 2026 置信度 0.87
• Optimization of Agrobacterium-mediated transformation of commercial heirloom tomato cultivars to develop novel traits via CRISPR/Cas9 genome editing.
  Main conclusion Trait development for commercial heirloom tomatoes can be advanced by optimization of tissue culture and transformation via Agrobacterium and CRISPR/Cas9 mutagenesis. Genetic improvement using new genome editing approaches relies on the efficie…
  europepmc 2026 置信度 0.87
• Genetically Modified Plants in Agriculture.
  Genetically modified (GM) plants have revolutionized agriculture for more than three decades. The production of a GM plants is a complex, multi-stage process. Several key methods are available for generating GM plants. The choice of transformation method depen…
  europepmc 2026 置信度 0.87
• Assessing off-target effects in CRISPR/Cas9: challenges and strategies for precision DNA editing.
  The emergence of CRISPR/Cas9 technology has transformed the landscape of gene editing, allowing for precise alterations in DNA that hold great promise for research and potential therapies. However, a significant concern is the occurrence of off-target effects,…
  europepmc 2026 置信度 0.94 psychologycomputer scienceneurosciencedata sciencecomputational biology
• Evaluation of Bna.SCT and Bna.REF1 as Target Genes to Reduce Sinapine in Rapeseed Using a Protoplast-Based CRISPR RNP Approach.
  Rapeseed is a major oil crop worldwide, producing both oil and a high amount of protein. However, the use of its seed meal as a protein source for animal feed is limited by antinutritional factors, such as sinapine, which reduces nutrient absorption and affect…
  europepmc 2026 置信度 0.87
• Nanocarrier-mediated CRISPR-Cas delivery: a novel approach against antibiotic-resistant superbugs.
  Antibiotic resistance (ABR) is a leading cause of death and a major public health threat globally. Without appropriate interventions, annual ABR-associated deaths have been projected to reach 10 million by 2050 worldwide. Hence, it is critical to develop novel…
  europepmc 2026 置信度 0.87
• Multiplexed CRISPR base editing enables pulse-activated irreversible biocontainment of engineered bacteria.
  The environmental and therapeutic application of genetically engineered microorganisms necessitates the development of robust, irreversible biocontainment systems. In this study, we present an eEGM (editing-driven essential gene multiplex inactivation) module …
  europepmc 2026 置信度 0.87
• A heterologous marker-free selection approach for CRISPR/Cas9-based gene editing in the malaria parasite <i>Plasmodium falciparum</i>.
  CRISPR/Cas9-based gene editing of the malaria parasite Plasmodium falciparum has emerged as a transformative tool for advancing functional studies on parasite biology and identifying new therapeutic targets. Currently applied CRISPR/Cas9 methodologies depend o…
  europepmc 2026 置信度 0.87
• Genetic medicines for epilepsy: unlocking new avenues for seizure control.
  Epilepsy affects millions of people globally and is marked by unpredictable seizures due to excessive brain activity. These seizures not only vary widely in brain origin and severity but can also be associated with a range of factors - from head injuries to in…
  europepmc 2026 置信度 0.87
• Evaluating the scientific and regulatory case for the deployment of the radioresistant genus <i>Deinococcus</i> in bioremediation.
  Industrial activities and legacy contamination have generated metal-laden soils, radionuclide plumes, solvent-saturated sediments, and acidified pollutants. These are complex, hostile matrices where chemical treatments often redistribute rather than eliminate …
  europepmc 2026 置信度 0.87
• An AI-driven framework for enhancing regulatory precision and efficiency in CRISPR-Cas gene-edited crops: challenges, opportunities, and global harmonization.
  Introduction The rapid advancement and adoption of CRISPR-Cas technologies in crop improvement has significantly outpaced existing regulatory frameworks, leading to inconsistencies in the global oversight of gene-edited organisms. As governments and internatio…
  europepmc 2025 置信度 0.87
• Topic "Application of Reproductive and Genomic Biotechnologies for Livestock Breeding and Selection".
  The escalating global demand for animal products-meat, milk, and eggs-requires sustained advances in the efficiency, sustainability, and biological performance of livestock production systems [...].
  europepmc 2026 置信度 0.81
• Conjugation as an evolutionary bottleneck in antimicrobial resistance spread.
  Antimicrobial resistance (AMR) is commonly framed as a consequence of mutation and selection, yet this perspective does not fully explain the speed and scale of global resistance dissemination. Here, we argue that AMR is better understood as an amplification p…
  europepmc 2026 置信度 0.87
• Features affecting Cas9-induced editing efficiency and patterns in tomato: evidence from a large CRISPR dataset.
  CRISPR/Cas9 is a cornerstone of plant genome editing, yet the determinants of editing efficiency for a given single-guide RNAs (sgRNAs) and DNA double-strand break (DSB) repair outcomes remain poorly understood, particularly in plants. Here, we generated a lar…
  europepmc 2026 置信度 0.87
• The future of reproduction in Eve Smith's <i>Off Target</i> and Kira Peikoff's <i>Baby X</i>.
  This essay analyses two novels that explore reproductive scenarios which may be implemented in the near future: human germline genome editing and in vitro gametogenesis (IVG), dramatised in Eve Smith's Off-Target (2022) and Kira Peikoff's Baby X (2024), respec…
  europepmc 2026 置信度 0.87
• Virus-induced genome editing enables functional genomics across diverse plant species.
  Virus-induced genome editing (VIGE) is expanding plant functional genomics by enabling precise and heritable genome modification across diverse species. While classical model systems such as Arabidopsis thaliana have provided foundational genetic insights, man…
  europepmc 2026 置信度 0.87
• Engineering plant architecture in the ornamental species Eustoma grandiflorum by knockout of strigolactone biosynthesis.
  Key message The targeted mutation of the strigolactone biosynthetic gene, CCD8, through genome-editing CRISPR-Cas9 induces dwarfism and enhanced branching in Eustoma grandiflorum. In ornamental plants, modifying shoot architecture is a major breeding objective…
  europepmc 2026 置信度 0.87
• Induced pluripotent stem cells as platforms for engineering NK cell immunotherapies.
  Human induced pluripotent stem cells (iPSCs) are transforming adoptive cell therapy by combining unlimited self-renewal, broad differentiation potential, and high amenability to genome engineering. These attributes make iPSCs a versatile source for the develop…
  europepmc 2026 置信度 0.87
• A rapid Agrobacterium rhizogenes-mediated transient expression for assessing sgRNA efficiency in CRISPR-Act3.0 in tomato.
  Key message CRISPR-Act3.0 is a robust tool for modulating fatty acid profiles in plants. We demonstrate that Agrobacterium rhizogenes-mediated transformation provides a rapid, cost-effective, and equipment-independent platform for validating sgRNA efficiency a…
  europepmc 2026 置信度 0.87
• The CRISPR-Cas toolkit for mosquito-borne virus surveillance: detection, tracing, and discovery.
  Mosquito-borne virus surveillance increasingly requires rapid, distributed detection of co-circulating pathogens, serotypes, and lineages across clinical and vector-sampling sites. CRISPR-Cas platforms offer a programmable toolkit for this purpose, but their r…
  europepmc 2026 置信度 0.87
• A versatile VLP-mediated CRISPR-RNP platform for precise genome editing and durable epigenome silencing in cancer.
  Clustered regularly interspaced short palindromic repeats (CRISPR)-based genome and epigenome editing hold great promise for precision therapy, yet their clinical translation is limited by delivery challenges. Here, we present a transient, DNA-free virus-like …
  europepmc 2026 置信度 0.87
• CRISPR-Cas-Mediated Reprogramming Strategies to Overcome Antimicrobial Resistance.
  Antimicrobial resistance (AMR) is escalating worldwide, posing a serious threat to global public health by driving infections that are no longer treatable with conventional antibiotics. CRISPR-Cas technology offers a programmable and highly specific therapeuti…
  europepmc 2026 置信度 0.87
• Global Research Trends and Hotspots in Gene Editing and Stem Cell Therapies for Neurodegenerative Diseases: Bibliometric and Visualization Analysis.
  Background Neurodegenerative diseases are a major and growing global health burden. Their pathogenesis is complex, and effective therapies remain limited. Gene editing and stem cell-based strategies are reshaping the therapeutic landscape. However, the field h…
  europepmc 2026 置信度 0.87
• CRISPR-Cas9-based gene editing as a proof-of-concept approach in an inborn error of immunity caused by a DCLRE1C variant.
  Hypomorphic DCLRE1C variants impair T and B cell development, leading to combined immunodeficiency (CID) or leaky severe combined immunodeficiency (SCID). Current treatment options, such as allogeneic hematopoietic stem cell transplantation (aHSCT), are associ…
  europepmc 2026 置信度 0.87
• CRISPR and the Future of Cardiac Disease Therapy: A New Genetic Frontier.
  CRISPR technologies are transforming cardiovascular therapy development by creating an increasingly seamless pipeline from potential target discovery to clinical translation. What began as a genome-editing tool has evolved into a versatile platform that enable…
  europepmc 2026 置信度 0.87
• The dynamic interplay between <i>Staphylococcus pseudintermedius</i> and canine immunity: mechanisms of pathogenesis, evasion, and vaccination perspectives.
  Staphylococcus pseudintermedius is a common commensal bacterium of dogs. It becomes an opportunistic pathogen when it evades the immune and exogenous antimicrobial control to cause pyoderma, otitis, and postoperative infections in dogs. The shift from coloniza…
  europepmc 2026 置信度 0.87
• Genomic profiling of ESBL/AmpC-producing <i>Escherichia coli</i> from backyard poultry: resistome, virulome, plasmidome, and CRISPR-Cas insights.
  Introduction Antimicrobial resistance (AMR) is a major One Health concern driven by many factors including unregulated animal farming. This study aimed to perform a comprehensive phenotypic and genotypic characterization of Escherichia coli isolated from backy…
  europepmc 2026 置信度 0.87
• Emerging therapies for type 1 diabetes: Immunotherapy and gene editing advances.
  Type 1 diabetes is a chronic autoimmune disease involving the specific destruction of pancreatic β-cells and consequent absolute insulin deficiency. Although exogenous insulin replacement aids in hyperglycemic management, it does not cure the disease and incre…
  europepmc 2026 置信度 0.87
• Cytosolic localization of MBL-1/Muscleblind may be required for ectopic neurite outgrowth in a sensitized background in <i>C. elegans</i>.
  The evolutionarily conserved RNA-binding protein Muscleblind can function as both a splicing regulator in the nucleus and a mRNA stabilizer in the cytosol. C. elegans mbl-1/ Muscleblind undergoes alternative splicing to generate long and short isoforms that co…
  europepmc 2026 置信度 0.87
• Commentary: CRISPR-Cas systems against carbapenem resistance-from proof-of-concept to clinical translation.
  Terminology (used consistently throughout): "sequence-guided therapeutics" refers to interventions whose target selection, triage, and monitoring are anchored to pathogen sequence features (genes/variants) rather than phenotype alone; "programmability" refers …
  europepmc 2026 置信度 0.87
• Advances in Double-Stranded DNA Targeting Technologies.
  Double-stranded DNA (dsDNA) serves as a fundamental repository of genetic information and plays a pivotal role in the diagnosis and therapeutic management of diseases. However, the inherent stability of the DNA double helix under physiological conditions prese…
  europepmc 2026 置信度 0.87
• Double-CRISPR Knockout Simulation (DKOsim): A Monte-Carlo randomization system to model cell growth behavior and infer the optimal library design for growth-based double knockout screens.
  Advances in functional genomic technology, notably CRISPR using Cas9 or Cas12, now allow for large-scale double perturbation screens in which pairs of genes are inactivated, allowing for the experimental detection of genetic interactions (GIs). However, as it …
  europepmc 2026 置信度 0.87
• Functional analysis of genes enriched in male reproductive organs: validation via fertility assessment of 14 knockout mouse lines.
  Tissue-restricted gene expression serves as a key indicator of functional importance within specific organs. Despite advances in high-throughput sequencing and genome editing over the past decade, this principle remains the gold standard for identifying candid…
  europepmc 2026 置信度 0.87
• Advances and prospects of genomic-assisted breeding in roots, tubers, and banana crops.
  Roots, Tubers, and Bananas (RTB), including banana and plantain, cassava, yam, sweetpotato, and potato crops, share several defining features that set them apart from cereals and legumes. They are essential for food and nutritional security for hundreds of mil…
  europepmc 2026 置信度 0.87
• AcrIIA8 is a putative phage structural protein of the HTJ2 family that does not inhibit Streptococcus pyogenes Cas9.
  Anti-CRISPR (Acr) proteins are phage-encoded anti-defense factors that suppress CRISPR-Cas immunity in bacteria. AcrIIA8 was previously identified as an inhibitor of Streptococcus pyogenes Cas9 (SpyCas9) through functional assays of metagenomic libraries. Here…
  europepmc 2026 置信度 0.87
• Bibliometric analysis of genetically engineered bacteria in tumor therapy.
  The utilization of bacteria for tumor treatment has a long-standing history. In recent years, with the continuous advancement of genetic engineering technologies, genetically engineered bacteria have attracted widespread attention in tumor-related research; ho…
  europepmc 2026 置信度 0.87
• Application of extracellular vesicles in the CRISPR-based diagnosis and treatment: possibilities and challenges.
  The CRISPR–Cas system has revolutionized molecular diagnostics and gene editing, yet its clinical translation is hindered by delivery barriers, off-target activity, immunogenicity, and manufacturing challenges. Compared with viral vectors and synthetic non-vir…
  europepmc 2026 置信度 0.87
• CRISPR mediated PRRS resistant pigs: biological success, welfare implications, and ethical regulatory challenges for sustainable swine production.
  Porcine reproductive and respiratory syndrome (PRRS) remains one of the most significant health and welfare challenges in global pig production. The disease is associated with substantial economic losses, impaired herd health, increased antimicrobial use, and …
  europepmc 2026 置信度 0.87
• DNA repair under heat: DNA polymerase λ modulates heat stress-induced mutagenesis in plants.
  Mutation rates often rise under environmental stress, a process known as stress-induced mutagenesis. Among abiotic factors, heat stress is a potent driver that elevates mutation rates and enhances genetic variation, yet the underlying mechanisms in eukaryotes …
  europepmc 2026 置信度 0.87
• Nanocarriers for the delivery of the CRISPR/Cas9 system.
  The clustered regularly interspaced short palindromic repeat/associated protein 9 (CRISPR/Cas9) system has been used for the precise manipulation of target DNA, making efficient genome editing in cells a reality. The CRISPR/Cas9 system has shown great potentia…
  europepmc 2026 置信度 0.87
• The Emergence of a CRISPR-Cas Revolution in Ecology: Applications, Challenges, and an Ecologist's Overview of the Toolbox.
  CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR-associated nucleases) systems allow researchers to detect, capture, and even alter parts of an organism's genome. However, while the use of CRISPR-Cas has revolutionised many fields i…
  europepmc 2026 置信度 0.87
• Toward an age of CRISPR delivery with non-viral biologics.
  A major goal in CRISPR/Cas gene therapy delivery is achieving biocompatible, transient delivery of gene editing machinery directly in patients. Among emerging delivery options, extracellular vesicles (EVs) hold promise as a new class of non-viral biologically …
  europepmc 2026 置信度 0.87
• Advancements in CRISPR-based therapies for ocular pathologies: from disease mechanisms to intervention strategies.
  Eye diseases caused by genetic mutations affect over 2.2 billion people worldwide. The development of CRISPR technology has opened exciting possibilities for how we diagnose and treat these conditions. However, designing effective CRISPR systems, managing pote…
  europepmc 2026 置信度 0.87
• Genetic Interruption of PD-1/PD-L1 as an Alternative Means for Immune Checkpoint Blockade in Cancer: A Review.
  Background/Objectives : Immune checkpoints are critical regulatory pathways that maintain peripheral tolerance and prevent autoimmunity. Among these, the programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) axis serves as a major inhibitory pathway that t…
  europepmc 2026 置信度 0.87
• Protoplast-Based Functional Genomics and Genome Editing: Progress, Challenges and Applications.
  Protoplast-based systems provide a powerful and versatile platform for exploring how plants sense and respond to their environment. By enabling the direct delivery of proteins, DNA, and RNA into plant cells after cell wall removal, this approach facilitates pr…
  europepmc 2026 置信度 0.87
• CRISPR/Cas9-based programmable genome editing in chickens: concepts, applications and regulatory issues.
  The advent of genetics, molecular biology, and genome sequencing has rapidly accelerated the development of elite genetic lines across various species, including poultry. It is now possible to introduce intra- or inter-species single nucleotide polymorphisms i…
  europepmc 2025 置信度 0.87
• CRISPR Applications in Alzheimer's Disease: From High-Throughput Genetic Screening to Precision Editing and CNS Delivery.
  Alzheimer's disease is a devastating progressive neurodegenerative disorder characterized by extracellular amyloid-beta plaques and intracellular tau tangles. Despite recent advancements in amyloid-beta-targeting immunotherapies, achieving safe and definitive …
  europepmc 2026 置信度 0.87
• Bibliometric-Based Analysis of Global Trends and Collaborative Networks in Plant Genetic Engineering (1994-2024).
  Agricultural sustainability faces serious challenges from population growth, climate change and ecological degradation. Genetic modification (GM) technology can be regarded as a precise extension of the Green Revolution, aiming to balance yield enhancement wit…
  europepmc 2026 置信度 0.87
• Expanding the CRISPR/Cas toolkit: applications in proteomics and theranostics.
  Conventional methods available for genome editing have proven non-specific, labour-intensive, and time-consuming. In this context, CRISPR/Cas technology represents a significant breakthrough. It is derived from a sophisticated microbial defence system consisti…
  europepmc 2025 置信度 0.87
• Resetting the epigenetic clock: cellular senescence and regenerative strategies in intervertebral disc degeneration.
  Intervertebral disc degeneration (IDD) is the leading pathological cause of low back pain, while current clinical treatments are only palliative and cannot reverse the programmed cellular senescence driven by epigenetic dysregulation. This process is character…
  europepmc 2026 置信度 0.87
• Research note: A novel double-gene deleted vaccine against hypervirulent MDV variant generated by CRISPR/Cas9-based gene editing.
  Marek's disease (MD), an important avian immunosuppressive and neoplastic diseases, has resulted in huge economic losses for the poultry industry worldwide. Over the past 50 years, the long-term prevalence of this disease and the growing immune pressure of MD …
  europepmc 2026 置信度 0.87
• Optimizing phage therapy with antidefense proteins acquired from the environment.
  With an estimated number of 10 31 , bacteriophages are ubiquitous biological entities prevalent in various ecological niches (Hendrix et al., 1999;Mushegian, 2020). These viruses are natural predators of bacteria and pose a persistent threat to their populatio…
  europepmc 2026 置信度 0.87
• Applications and Challenges of CRISPR-Cas Technology for the Detection of Antimicrobial Resistance Genes.
  The global rise of antimicrobial resistance (AMR) demands rapid and precise diagnostic tools capable of providing actionable results at the point of care. Traditional methods, including bacterial culture and PCR, face critical limitations: culture-based approa…
  europepmc 2026 置信度 0.87
• Gene Editing Strategies for Neurological and Mental Disorders: Advances in Delivery, Methodology, and Clinical Translation.
  Neurological and mental disorders are among the main causes of disability worldwide, affecting over three billion people and increasing the socioeconomic burden. Advances in molecular genetics and genome engineering have led to gene-targeted therapies that add…
  europepmc 2026 置信度 0.87
• Functional Validation of the Melon Fom-1 Gene, Controlling Resistance to Fusarium oxysporum Races 0 and 2, by CRISPR/Cas9 Mutagenesis.
  Functional validation of NLR genes is critical for confirming their specific roles and developing durable disease-resistant crops. The Fom-1 gene of Cucumis melo, controlling resistance to races 0 and 2 of F. oxysporum f. sp. melonis (FOM), had been identified…
  europepmc 2026 置信度 0.87
• Engineering non-coding DNA Elements in Rice: an Elegant Approach To fine-tune Agronomical Advantageous Traits.
  Rice serves as a fundamental staple crop, supporting the dietary needs of nearly one-third of the global population. This critical role necessitates immediate and strategic efforts to develop multi-attribute genotypes to ensure sustainable food and nutritional…
  europepmc 2025 置信度 0.87
• Novel genome editing approaches to manipulate apical meristem activity for crop yield.
  Meristem function underlies organogenesis and yield potential in crop species, and its regulation depends on the crosstalk of genetic and hormonal networks that balance stem-cell niche maintenance and differentiation. During the shoot apical meristem (SAM) tra…
  europepmc 2026 置信度 0.87
• Specific elimination of m.8993T>G mitochondrial haplotype in NARP cybrid cells by CRISPR-Cas9 system.
  Mutations in mitochondrial DNA can cause a wide range of neuromuscular and neurodegenerative diseases in humans. The heteroplasmy level, coexistence of both wild-type and mutant mtDNA within a cell, determines the manifestation and severity of disease symptoms…
  europepmc 2026 置信度 0.87
• A practical guide for characterization of novel CRISPR-Cas systems with Pro-CRISPR factors.
  The emergence of advanced genome editing technologies has revolutionized research in life sciences, offering an unprecedented way to uncover unknown biological functions and innovative therapeutic strategies. Among all genome editing tools, CRISPR-Cas-based te…
  europepmc 2026 置信度 0.87
• Gene editing to enhance biotic stress tolerance in sugarcane.
  Sugarcane (Saccharum spp.) contributes approximately 80% of global sugar production and 40% of biofuel while serving as a promising feedstock for bioproducts (Brant et al., 2025). However, productivity faces mounting challenges from biotic threats including fu…
  europepmc 2025 置信度 0.87
• Emerging tools in plant genome editing.
  Plant genome editing has undergone a transformative shift with the advent of advanced molecular tools, offering unprecedented levels of precision, flexibility and efficiency in modifying genetic material. While classical site-directed nucleases such as ZFNs, T…
  europepmc 2025 置信度 0.87
• Dual Effect of <i>EZH2</i> Gene Editing with CRISPR/Cas9 in Lung Cancer.
  Lung adenocarcinoma is the most common form of lung cancer with a 5-year survival rate of 15%, largely due to asymptomatic metastasis and late diagnosis. Overexpression of Polycomb group (PcG) proteins, particularly EZH2, the catalytic component of Polycomb Re…
  europepmc 2026 置信度 0.87
• Harnessing myostatin pleiotropy for multitrait improvement via precision gene editing.
  The pursuit of sustainable livestock farming to meet the rising global protein demand has positioned myostatin (MSTN) gene editing as a key technology. However, the field's focus on the remarkable double-muscle phenotype has often overshadowed a systematic exa…
  europepmc 2026 置信度 0.87
• Peptide-assisted lipofection enables efficient non-viral delivery of large CRISPR/Cas9 constructs for genome editing applications.
  Efficient and safe delivery of large genetic constructs such as CRISPR/Cas9 plasmids remains a critical bottleneck in gene therapy. In this work, the peptide-assisted lipofection (PAL) system was developed as a breakthrough non-viral vector for gene delivery, …
  europepmc 2025 置信度 0.87
• Application and Research Prospects of CRISPR/Cas Gene Editing Technology in Lactic Acid Bacteria.
  Lactic acid bacteria (LAB) are pivotal microorganisms in the food industry. Current approaches for functional gene validation and trait improvement in LAB primarily rely on traditional gene editing and homologous recombination techniques. These methods are oft…
  europepmc 2026 置信度 0.87
• Physiologically relevant 3D CRISPR screening enhances mechanistic insight into chemical toxicity compared to 2D screening.
  CRISPR-based approaches can complement other genomics-based toxicology studies by enabling causal interrogation of gene function modulating chemical-induced toxicity. Moreover, CRISPR screens enable scalable and systematic identification of functional pathways…
  europepmc 2026 置信度 0.87
• Clinical outcome of an SCNT-derived <i>MSTN</i> knockout buffalo: a case study.
  Myostatin ( MSTN ) gene knockout has attracted considerable interest for enhancing meat production in livestock species due to its well-established role as a negative regulator of skeletal muscle growth. In this study, we report the clinical outcome of a bi-al…
  europepmc 2026 置信度 0.87
• Using ngTALEN to improve genome editing efficiency on targets containing 5-methylcytosines.
  We recently discovered distinct methylation patterns between the mitochondrial genome and the nuclear-encoded mitochondrial DNA sequences (NUMTs), with the mitochondrial genome being hypomethylated and NUMTs being hypermethylated. Given that genome editing usi…
  europepmc 2026 置信度 0.87
• Emerging CRISPR Approaches for Countering Immune Evasion: Insight from Recent Studies.
  Cancer immunotherapy has recently become an essential approach for treating cancer, showing considerable promise as a substitute for surgery, radiation therapy, and conventional chemotherapy. It primarily aims to boost the host's natural defense system to comb…
  europepmc 2026 置信度 0.87
• CRISPR/Cas12a: A Comprehensive Review from Structural Foundations to Applications in Nucleic Acid Precision Detection.
  CRISPR/Cas12a technology, characterized by its distinctive trans-cleavage activity, has evolved beyond its gene-editing function to emerge as a powerful tool for molecular detection. This review systematically delineates its structural foundation and molecular…
  europepmc 2026 置信度 0.94 computer sciencepharmacologymedicinetransformative learningbiological sciences not elsewhere classified
• Rebuilding the degenerative disc microenvironment: mesenchymal stem cells, exosomes, and bioengineered scaffolds.
  Intervertebral disc degeneration (IVDD) is a leading cause of chronic low back pain, yet current clinical interventions remain largely palliative and fail to restore disc structure and function. While mesenchymal stem cells (MSCs), exosomes, and bioengineered …
  europepmc 2026 置信度 0.87
• Targeting biofilm-driven antibiotic resistance: emerging mechanisms and next-generation therapeutic interventions.
  Biofilm mediated antimicrobial resistance (AMR) has become a critical global health and economic challenge, affecting both community and healthcare settings. Microbial Biofilms significantly enhance the antibiotic tolerance and cause the persistent and device-…
  europepmc 2026 置信度 0.87
• Current and Emerging Therapeutic Strategies for the Treatment of Duchenne Muscular Dystrophy.
  Background/Objectives : Duchenne muscular dystrophy (DMD) is a fatal, progressive neuromuscular disorder caused by mutations in the dystrophin gene, leading to the absence of functional dystrophin protein. As the largest gene in the human genome, the DMD locus…
  europepmc 2026 置信度 0.87
• Feature representation for explainable CRISPR off-target prediction and base editing efficiency.
  Introduction The interaction between guide RNAs (gRNAs) and target DNA sequences is a critical factor in the effectiveness of CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated protein 9) gene editing. Predicting these int…
  europepmc 2026 置信度 0.87
• Viral genome editing methods and applications in the CRISPR era.
  CRISPR-Cas systems have transformed viral genetics by enabling precise and efficient manipulation of large DNA virus genomes. This review provides a practical framework for applying CRISPR technology to herpesviruses and other large DNA viruses as an alternati…
  europepmc 2026 置信度 0.87

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