基因技术工具 · 全部实体（第 1 / 100 页）

本页收录第 1–100 条，共 10000 条 · 返回 基因技术工具 首页

• Reconstructing Past Admixture Processes from Local Genomic Ancestry Using Wavelet Transformation
  Admixture between long-separated populations is a defining feature of the genomes of many species. The mosaic block structure of admixed genomes can provide information about past contact events, including the time and extent of admixture. Here, we describe an…
  openalex Jean Sanderson, Herawati Sudoyo, Tatiana M. Karafet, Michael F. Hammer 等 2015-04-07 置信度 0.72 WaveletBiologyGenomeCoalescent theoryRange (aeronautics)
• When genomics goes digital
  openalex Evan D. Muse, Ali Torkamani, Eric J. Topol 2018-06-01 置信度 0.72 GenomicsComputational biologyComputer scienceBiologyGenetics
• Trypanosoma cruzi: Genomic Diversity and Structure
  Trypanosoma cruzi is the causative agent of Chagas disease, a neglected tropical disease, and one of the most important parasitic diseases worldwide. The first genome of T. cruzi was sequenced in 2005, and its complexity made assembly and annotation challengin…
  openalex Alfonso Herreros‐Cabello, Francisco Callejas‐Hernández, Núria Gironès, Manuel Fresno 2025-01-12 置信度 0.72 BiologyTrypanosoma cruziGenomeGeneGenetics
• Artificial Intelligence in Ayurveda: A Systematic Review (2020-2025)
  Background: Ayurveda, the ancient Indian system of medicine, emphasizes personalized holistic care, presenting unique opportunities for integration with Artificial Intelligence (AI). Since 2020, a growing body of research has explored AI applications in Ayurve…
  openalex Srishti Shaumya, R. Mathusoothana S. Kumar 2025-07-01 置信度 0.72 PsychologyData scienceArtificial intelligenceComputer scienceCognitive science
• Farm animal genetic and genomic resources from an agroecological perspective
  absent
  openalex Michèle Tixier‐Boichard, Étienne Verrier, Xavier Rognon, Tatiana Zerjal 2015-04-30 置信度 0.72 AgroecologyGenomicsLivestockPerspective (graphical)Genetic resources
• TAREAN: a computational tool for identification and characterization of satellite DNA from unassembled short reads
  Satellite DNA is one of the major classes of repetitive DNA, characterized by tandemly arranged repeat copies that form contiguous arrays up to megabases in length. This type of genomic organization makes satellite DNA difficult to assemble, which hampers char…
  openalex Petr Novák, Laura Ávila Robledillo, Andrea Koblížková, Iva Vrbová 等 2017-04-05 置信度 0.72 BiologySatellite DNATandem repeatGenomeContig
• Population genomics highlights structural variations in local adaptation to saline coastal environments in woolly grape
  Structural variations (SVs) are a feature of plant genomes that has been largely unexplored despite their significant impact on plant phenotypic traits and local adaptation to abiotic and biotic stress. In this study, we employed woolly grape (Vitis retordii),…
  openalex Tianhao Zhang, Wenjing Peng, Hua Xiao, Shuo Cao 等 2024-04-05 置信度 0.72 Local adaptationBiologyAdaptation (eye)PopulationCandidate gene
• OrthoDB and BUSCO update: annotation of orthologs with wider sampling of genomes
  OrthoDB (https://www.orthodb.org) offers evolutionary and functional annotations of orthologous genes in the widest sampling of eukaryotes, prokaryotes, and viruses, extending experimental gene function knowledge to newly sequenced genomes. We collect gene ann…
  openalex Fredrik Tegenfeldt, Dmitry Kuznetsov, Mosè Manni, Matthew Berkeley 等 2024-11-12 置信度 0.72 BiologyGenomeGeneAnnotationGenetics
• Genetics, genomics and clinical features of adenomatous polyposis
  Adenomatous polyposis syndromes are hereditary conditions characterised by the development of multiple adenomas in the gastrointestinal tract, particularly in the colon and rectum, significantly increasing the risk of colorectal cancer and, in some cases, extr…
  openalex Jihoon E. Joo, Julen Viana-Errasti, Daniel D. Buchanan, Laura Valle 2025-04-16 置信度 0.72 MUTYHFamilial adenomatous polyposisBiologyAdenomatous polyposis coliDNA mismatch repair
• Personalized antisense oligonucleotides ‘for free, for life’ — the n-Lorem Foundation
  openalex Joseph G. Gleeson, C. Frank Bennett, Jeffrey B. Carroll, Tracy Cole 等 2023-05-11 置信度 0.72 OligonucleotideFoundation (evidence)Computational biologyBiologyMedicine
• Clinical and Genomic Risk for Late Breast Cancer Recurrence and Survival
  BACKGROUND: The 21-gene recurrence score (RS) assay (Oncotype DX) is used to guide adjuvant chemotherapy use for patients with hormone receptor-positive, HER2 (human epidermal growth factor receptor 2)-negative, axillary node-negative breast cancer. Its role, …
  openalex Joseph A. Sparano, Michael Crager, Robert J. Gray, Gong Tang 等 2024-07-23 置信度 0.72 Breast cancerMedicineOncologyCancerInternal medicine
• Multiomics of a rice population identifies genes and genomic regions that bestow low glycemic index and high protein content
  To counter the rising incidence of diabetes and to meet the daily protein needs, we created low glycemic index (GI) rice varieties with protein content (PC) surpassing 14%. In the development of recombinant inbred lines using Samba Mahsuri and IR36 amylose ext…
  openalex Saurabh Badoni, Erstelle A. Pasion-Uy, Sakshi Kor, Sung‐Ryul Kim 等 2024-08-27 置信度 0.72 AmyloseBiologyQuantitative trait locusGeneGenetics
• Genomic analysis of the natural history of attention-deficit/hyperactivity disorder using Neanderthal and ancient Homo sapiens samples
  Attention-deficit/hyperactivity disorder (ADHD) is an impairing neurodevelopmental condition highly prevalent in current populations. Several hypotheses have been proposed to explain this paradox, mainly in the context of the Paleolithic versus Neolithic cultu…
  openalex Paula Esteller-Cucala, Iago Maceda, Anders D. Børglum, Ditte Demontis 等 2020-05-25 置信度 0.72 NeanderthalContext (archaeology)AlleleIntrogressionAttention deficit hyperactivity disorder
• Genomic analysis of lean individuals with NAFLD identifies monogenic disorders in a prospective cohort study
  Background & Aims: Lean patients with non-alcoholic fatty liver disease (NAFLD) represent 10-20% of the affected population and may have heterogeneous drivers of disease. We have recently proposed the evaluation of patients with lean NAFLD without visceral adi…
  openalex Melanie Zheng, Daniel Q. Huang, Chigoziri Konkwo, Saaket Agrawal 等 2023-02-02 置信度 0.72 Fatty liverExome sequencingMedicineDiseaseExome
• Isolation of cDNAs encoding the complete sequence of bovine type X collagen. Evidence for the condensed nature of mammalian type X collagen genes
  The complete primary structure of the bovine alpha 1(X) collagen chain was determined by nucleotide sequencing of cDNA clones. The overlapping cDNA clones encode 3144 bp with a 5'-terminal untranslated region of 148 bp, a 2025 bp reading frame and a 3'-termina…
  openalex Jack Thomas, Alvin P.L. Kwan, Michael E. Grant, Ray Boot-Handford 1991-01-01 置信度 0.72 Complementary DNAUntranslated regionBiologyMolecular biologyExon
• Metabolic marker-assisted genomic prediction improves hybrid breeding
  Hybrid breeding is widely acknowledged as the most effective method for increasing crop yield, particularly in maize and rice. However, a major challenge in hybrid breeding is the selection of desirable combinations from the vast pool of potential crosses. Gen…
  openalex Yang Xu, Wenyan Yang, Jie Qiu, Kai Zhou 等 2024-11-28 置信度 0.72 Genomic selectionComputational biologyBiologyMarker-assisted selectionGenetics
• Genomic, molecular, and cellular divergence of the human brain
  While many core biological processes are conserved across species, the human brain has evolved with unique capacities. Current understanding of the neurobiological mechanisms that endow human traits as well as associated vulnerabilities remains limited. Howeve…
  openalex Ralda Nehme, Olli Pietiläinen, Lindy E. Barrett 2024-06-18 置信度 0.72 NeuroscienceHuman brainDivergence (linguistics)BiologyHuman genome
• Genomic adaptation of Clostridium perfringens to human intestine
  Abstract Clostridium perfringens is often associated with foodborne diseases, posing significant public health risks. However, genomic investigation of C. perfringens isolates from the human population has been lacking. This study aims to fill this knowledge g…
  openalex Ke Wu, Juan Wang, Zelin Yan, Yanyan Zhu 等 2024-10-25 置信度 0.72 Clostridium perfringensAdaptation (eye)MicrobiologyBiologyComputational biology
• Plant genomic and microbial interplay in the rhizosphere under salt stress: a review
  Soil salinization has been considered as a global problem in agriculture, which decreases crop productivity and threatens food security. Salt stress causes complex physiological damages in plants such as ionic imbalance, osmotic stress, and oxidative damage. H…
  openalex Yi Ren, He Yan, Aiyuan Ma 2026-01-07 置信度 0.72 RhizosphereBiologyRhizobacteriaMicrobiomeAbiotic stress
• Genomic Diversity as a Key Conservation Criterion: Proof‐of‐Concept From Mammalian Whole‐Genome Resequencing Data
  Many international, national, state, and local organizations prioritize the ranking of threatened and endangered species to help direct conservation efforts. For example, the International Union for Conservation of Nature (IUCN) assesses the Green Status of sp…
  openalex Jong Yoon Jeon, Andrew N. Black, Erangi J. Heenkenda, Andrew J. Mularo 等 2024-09-01 置信度 0.72 BiologyGenomeKey (lock)Computational biologyDiversity (politics)
• Gene-LLMs: a comprehensive survey of transformer-based genomic language models for regulatory and clinical genomics
  The convergence of natural language processing (NLP) and genomics has given rise to a new class of transformer-based models-genome large language models (Gene-LLMs)-capable of interpreting the language of life at an unprecedented scale and resolution. These mo…
  openalex P. Balakrishnan, A. Anny Leema, V. Dhivya Shree, Chadi Saad 等 2025-10-13 置信度 0.72 Computer scienceGenomicsInterpretabilityDECIPHERInference
• TNBC-DX genomic test in early-stage triple-negative breast cancer treated with neoadjuvant taxane-based therapy
  openalex M. Martín, S.R. Stecklein, Oleg Gluz, Guillermo Villacampa 等 2024-10-16 置信度 0.72 MedicineTaxaneTriple-negative breast cancerOncologyStage (stratigraphy)
• Policy implications of WHO’s global traditional medicine strategy 2025–2034
  aims to enhance the contribution of traditional, complementary and integrative medicine to achieving universal health coverage by strengthening the integration of evidence-based traditional, complementary and integrative medicine into national health systems. …
  openalex Yuk Ming Alice Wong, Sangyoungchol Ahn, Aditi Bana, Pradeep Kumar Dua 等 2025-11-01 置信度 0.72 Integrative medicineMisappropriationTraditional knowledgeIndigenousGlobal health
• Human β-defensins
  openalex Marzena Pazgier, David M. Hoover, De Yang, Weiyue Lu 等 2006-05-15 置信度 0.72 BiologyMicrobiologyChemistry
• The genomic origin of the unique chaetognath body plan
  Abstract The emergence of animal phyla, each with their unique body plan, was a rapid event in the history of animal life, yet its genomic underpinnings are still poorly understood1. Here we investigate at the genomic, regulatory and cellular levels, the origi…
  openalex Laura Piovani, Daria Gavriouchkina, Elise Parey, Luke A. Sarre 等 2025-08-13 置信度 0.72 Body planBiologyEvolutionary biologyZoologyComputational biology
• Antimicrobial resistance and genomic screening of clinical isolates of thermophilic Campylobacter spp. from south-east Queensland, Australia
  AIM: To screen 90 clinical isolates of thermophilic Campylobacter species for putative resistance to ampicillin, erythromycin and tetracycline and perform numerical analysis to determine isolate relatedness. METHODS AND RESULTS: Disc diffusion, E-test MIC and …
  openalex David A. Alfredson, R.J. Akhurst, Victoria Korolik 2003-03-01 置信度 0.72 TetracyclineErythromycinAgar dilutionAmpicillinCampylobacter
• Genomic diversity of Vibrio spp. and metagenomic analysis of pathogens in Florida Gulf coastal waters following Hurricane Ian
  ABSTRACT Changing climatic conditions influence parameters associated with the growth of pathogenic Vibrio spp. in the environment and, hence, are linked to increased incidence of vibriosis. Between 1992 and 2022, a long-term increase in Vibrio spp. infections…
  openalex Kyle D. Brumfield, Moiz Usmani, Sanneri Santiago, Komalpreet Singh 等 2023-10-16 置信度 0.72 VibrioVibrio vulnificusVibrio parahaemolyticusMetagenomicsBiology
• Genomic Profiling of Hormone-Naïve Lymph Node Metastases in Patients with Prostate Cancer
  The progression of organ-confined prostate cancer to metastatic cancer is inevitably fatal. Consequently, identification of structural changes in the genome and associated transcriptional responses that drive this progression is critical to understanding the d…
  openalex Pamela L. Paris, Matthias D. Hofer, Giancarlo Albo, Rainer Kuefer 等 2006-12-01 置信度 0.72 Prostate cancerLymph nodeComparative genomic hybridizationBiologyCopy number analysis
• MarkerDB 2.0: a comprehensive molecular biomarker database for 2025
  MarkerDB (https://markerdb.ca) has become a leading resource for comprehensive information on molecular biomarkers. Over the past 3 years, the database has evolved significantly, reflecting the dynamic landscape of biomarker research and increasing demands fro…
  openalex Hayley Jackson, Eponine Oler, Claudia Torres-Calzada, Ray Kruger 等 2024-10-25 置信度 0.72 BiomarkerUsabilityResource (disambiguation)Consistency (knowledge bases)Molecular biomarkers
• Social Genomic Determinants of Health: Understanding the Molecular Pathways by Which Neighborhood Disadvantage Affects Cancer Outcomes
  PURPOSE: Neighborhoods represent complex environments with unique social, cultural, physical, and economic attributes that have major impacts on disparities in health, disease, and survival. Neighborhood disadvantage is associated with shorter breast cancer re…
  openalex Neha Goel, Alexandra Hernández, Steve W. Cole 2024-08-23 置信度 0.72 Social determinants of healthPsychosocialHealth equitySocial epidemiologyDisease
• Sensitive and accurate detection of copy number variants using read depth of coverage
  Methods for the direct detection of copy number variation (CNV) genome-wide have become effective instruments for identifying genetic risk factors for disease. The application of next-generation sequencing platforms to genetic studies promises to improve sensi…
  openalex Seungtai Yoon, Zhenyu Xuan, Vladimir Makarov, Kenny Ye 等 2009-08-05 置信度 0.72 IndelCopy-number variationBiologyGenomeGenetics
• Blockchain-Based Privacy-Preserving System for Genomic Data Management Using Local Differential Privacy
  The advances made in genome technology have resulted in significant amounts of genomic data being generated at an increasing speed. As genomic data contain various privacy-sensitive information, security schemes that protect confidentiality and control access …
  openalex Young-Hoon Park, Yejin Kim, Junho Shim 2021-12-03 置信度 0.72 Differential privacyData sharingComputer scienceInformation privacyBlockchain
• Beyond genomics: artificial intelligence-powered diagnostics for indeterminate thyroid nodules—a systematic review and meta-analysis
  Introduction: In recent years, artificial intelligence (AI) tools have become widely studied for thyroid ultrasonography (USG) classification. The real-world applicability of these developed tools as pre-operative diagnostic aids is limited due to model overfi…
  openalex Karishma Jassal, Melissa Edwards, Afsaneh Koohestani, Wendy A. Brown 等 2025-05-05 置信度 0.72 IndeterminateThyroid nodulesGenomicsMeta-analysisMedicine
• Incorporating Genomics into Breast Cancer Clinical Trials and Care
  Advances in DNA sequencing provide the potential for clinical assays that are timely and affordable and use small amounts of clinical material. The hypothesis has therefore been raised that marked improvements in patient outcomes will result when DNA diagnosti…
  openalex Adel Tabchy, X. Cynthia, Ron Bose, Matthew J. Ellis 2013-12-01 置信度 0.72 DruggabilityGenomicsClinical trialCancerBreast cancer
• The polyploid continuum and the landscape of polyploid genomic variation
  Polyploid research has traditionally distinguished between autopolyploids and allopolyploids on the basis of evolutionary origins, modes of inheritance, or chromosomal pairing behavior during meiosis. It has long been recognized, however, that a binary classif…
  openalex Alex D. Twyford, Justin L. Conover, Jeff J. Doyle, Annaliese S. Mason 等 2025-11-01 置信度 0.72 PolyploidBiologyEvolutionary biologyPerspective (graphical)Ploidy
• Inferring effects of mutations on SARS-CoV-2 transmission from genomic surveillance data
  New and more transmissible variants of SARS-CoV-2 have arisen multiple times over the course of the pandemic. Rapidly identifying mutations that affect transmission could improve our understanding of viral biology and highlight new variants that warrant furthe…
  openalex Brian Lee, Ahmed Abdul Quadeer, Muhammad Saqib Sohail, Elizabeth Finney 等 2025-01-07 置信度 0.72 Transmission (telecommunications)BiologyGeneticsMutationComputational biology
• Genomic aberrations in diffuse low‐grade gliomas
  The current classification of diffuse low-grade gliomas is based mainly on histopathological criteria, which cannot accurately predict the highly variable clinical course observed in patients with such tumors. In an attempt to increase pathogenetic understandi…
  openalex Hanne‐Sofie S. Dahlback, Ludmila Gorunova, Petter Brandal, David Scheie 等 2011-03-15 置信度 0.72 Comparative genomic hybridizationKaryotypeBiologyGliomaPathology
• MEGA12: Molecular Evolutionary Genetic Analysis Version 12 for Adaptive and Green Computing
  We introduce the 12th version of the Molecular Evolutionary Genetics Analysis (MEGA12) software. This latest version brings many significant improvements by reducing the computational time needed for selecting optimal substitution models and conducting bootstr…
  openalex Sudhir Kumar, Glen Stecher, Michael Suleski, Maxwell Sanderford 等 2024-12-01 置信度 0.72 BiologyAdaptive evolutionEvolutionary biologyMolecular evolutionComputational biology
• Strategies for microsatellite isolation: a review
  In the last few years microsatellites have become one of the most popular molecular markers used with applications in many different fields. High polymorphism and the relative ease of scoring represent the two major features that make microsatellites of large …
  openalex Lorenzo Zane, Luca Bargelloni, Tomaso Patarnello 2002-01-01 置信度 0.72 MicrosatelliteBiologyIsolation (microbiology)Computational biologyEvolutionary biology
• Cloning and characterization of the genomic DNA of the human MSSP genes
  MSSP proteins have been identified by their binding to an upstream element of c-myc. Independently, two different approaches yielded two cDNA clones highly homologous to the MSSP cDNAs, suggesting an involvement of MSSP in the regulation of the cell cycle (scr…
  openalex Christian Haigermoser 1996-10-01 置信度 0.72 BiologyGeneGeneticsPromoterExon
• Genomic markers of recurrence risk in atypical meningioma following gross total resection
  Abstract Background Meningiomas are the most common primary central nervous system (CNS) tumor in adults and CNS World Health Organization grade 2 (atypical) meningiomas show an intermediate risk of recurrence/progression. Molecular parameters are needed to be…
  openalex Rachael A. Vaubel, Rahul Kumar, Taylor M. Weiskittel, Sarah M. Jenkins 等 2023-01-01 置信度 0.72 ResectionMeningiomaMedicineBiologyGenetics
• Comparing methods for detecting multilocus adaptation with multivariate genotype–environment associations
  Identifying adaptive loci can provide insight into the mechanisms underlying local adaptation. Genotype-environment association (GEA) methods, which identify these loci based on correlations between genetic and environmental data, are particularly promising. U…
  openalex Brenna R. Forester, Jesse R. Lasky, Helene H. Wagner, Dean L. Urban 2018-04-09 置信度 0.72 UnivariateBiologyMultivariate statisticsSelection (genetic algorithm)Local adaptation
• Stage-Specific Transcriptome and Proteome Analyses of the Filarial Parasite Onchocerca volvulus and Its Wolbachia Endosymbiont
  Onchocerciasis (river blindness) is a neglected tropical disease that has been successfully targeted by mass drug treatment programs in the Americas and small parts of Africa. Achieving the long-term goal of elimination of onchocerciasis, however, requires add…
  openalex Sasisekhar Bennuru, James A. Cotton, José M. C. Ribeiro, Alexandra Grote 等 2016-11-24 置信度 0.72 Onchocerca volvulusWolbachiaParasite hostingProteomeTranscriptome
• High concordance of actionable genomic alterations identified between circulating tumor DNA–based and tissue‐based next‐generation sequencing testing in advanced non–small cell lung cancer: The Korean Lung Liquid Versus Invasive Biopsy Program
  BACKGROUND: Because of the growing number of actionable biomarkers in non-small cell lung cancer (NSCLC), sufficient tissue availability for testing is becoming a greater challenge. Liquid biopsy offers a potential solution by complementing standard tissue-bas…
  openalex Sehhoon Park, Steve Olsen, Bo Mi Ku, Min‐Sang Lee 等 2021-04-07 置信度 0.72 ConcordanceMedicineLung cancerDNA sequencingPathology
• Cancer treatment and survivorship statistics, 2025: An urgent call to optimize health after cancer
  The publication of the American Cancer Society’s “Cancer Treatment and Survivorship Statistics, 2025” report affirms that the number of people living in the United States with a history of cancer is rising because of advances in detection and treatment that ha…
  openalex Lidia Schapira, Christine Duffy 2025-05-30 置信度 0.72 MedicineSurvivorship curveCancer survivorshipCancerCancer treatment
• Discoveries and advances in plant and animal genomics
  Plant and animal genomics is a broad area of research with respect to the biological issues covered because it continues to deal with the structure and function of genetic material underpinning all organisms. This mini-review utilizes the plenary lectures from…
  openalex R. Appels, Johan Nyström, Hollie Webster, Gabriel Keeble‐Gagnère 2015-03-01 置信度 0.72 GenomicsBiologyUnderpinningGenomeComputational biology
• A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)γa as a pancreatic beta cell-specific biomarker
  openalex Daisy Flamez, I. Roland, Alix Berton, Burak Kutlu 等 2010-04-08 置信度 0.72 Beta cellBiologyPancreatic isletsPancreasCell biology
• Genomic hallmarks of endocrine therapy resistance in ER/PR+HER2- breast tumours
  ER/PR+HER2- breast tumours are the most predominant subtype of breast cancer worldwide, including India. Unlike TNBCs, these tumours can be treated with anti-estrogens or aromatase inhibitors. Despite the success of endocrine therapy, a fraction of patients wi…
  openalex Arnab Ghosh, Rohan Chaubal, Chitrarpita Das, Pallavi Parab 等 2025-02-10 置信度 0.72 Breast cancerGenome instabilityEndocrine systemOncologyInternal medicine
• Post-genomic challenges for collaborative research in infectious diseases
  openalex Iruka N. Okeke, John Wain 2008-08-19 置信度 0.72 BiologyComputational biologyInfectious disease (medical specialty)VirologyGenetics
• Dollo’s law of irreversibility in the post-genomic age
  Dollo's law of irreversibility argues that evolution cannot revert to earlier states. It has remained controversial ever since its inception in the 19th century. Enabled by advances in phylogenomics and functional genomics, recent studies show that there are v…
  openalex Kathryn R. Elmer, Jean Clobert 2024-10-23 置信度 0.72 LawPolitical science
• AACR Pediatric Cancer Progress Report 2025
  On December 4, 2025, the American Association for Cancer Research (AACR) released its inaugural AACR Pediatric Cancer Progress Report, which highlights the remarkable scientific and clinical advances transforming outcomes for children (ages 0-14) and adolescen…
  openalex Kristin Primm, Elizabeth Blackman, Brett M. Sansbury, Sayyed Kaleem Zaidi 等 2026-02-04 置信度 0.72 MedicinePediatric cancerCancerMEDLINEPediatric research
• Genomics: what is realistically achievable?
  We now have a large and growing number of sequenced genomes. It is widely understood that this presents research opportunities and promises to change the way biology advances, but the magnitude and nature of the opportunities is, for the most part, poorly unde…
  openalex Ross Overbeek 2000-01-01 置信度 0.72 Data scienceComputer scienceField (mathematics)GenomicsFace (sociological concept)
• Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma
  Mitogen-activated protein kinase/extracellular signal-regulated protein kinase (MAPK/ERK) is a key molecule in intracellular signal transducing pathways that transport extracellular stimuli from cell surface to nuclei. MAPK/ERK has been revealed to be involved…
  openalex Yoshiki Ito, Yutaka Sasaki, Masayoshi Horimoto, Shigeo Wada 等 1998-04-01 置信度 0.72 MAPK/ERK pathwayKinaseCancer researchProtein kinase ACyclin D1
• Recent Advances in the Genomic Profiling of Bacterial Epigenetic Modifications
  Bacterial epigenetic modifications play key roles in cellular processes such as stress responses, DNA replication, segregation, antimicrobial resistance, etc. In recent years, emerging new sequencing technologies, including single-molecule real-time (SMRT) seq…
  openalex Liqiong Liu, Yizhou Zhang, Dongxu Jiang, Shiming Du 等 2018-06-07 置信度 0.72 EpigeneticsComputational biologyProfiling (computer programming)BiologyGenetics
• Recommendations for improving statistical inference in population genomics
  ABSTRACT The field of population genomics has grown rapidly in response to the recent advent of affordable, large-scale sequencing technologies. As opposed to the situation during the majority of the 20th century, in which the development of theoretical and st…
  openalex Parul Johri, Charles F. Aquadro, Mark Beaumont, Brian Charlesworth 等 2021-11-02 置信度 0.72 InferenceData scienceScrutinyPopulationStatistical inference
• Metagenomic global survey and in-depth genomic analyses of Ruminococcus gnavus reveal differences across host lifestyle and health status
  Ruminococcus gnavus is a gut bacterium found in > 90% of healthy individuals, but its increased abundance is also associated with chronic inflammatory diseases, particularly Crohn's disease. Nevertheless, its global distribution and intraspecies genomic variat…
  openalex Sam Nooij, Niels Plomp, Ingrid M. J. G. Sanders, L. Schout 等 2025-01-30 置信度 0.72 MetagenomicsHost (biology)RuminococcusBiologyEnvironmental health
• A Review of the Molecular Understanding of the Mpox Virus (MPXV): Genomics, Immune Evasion, and Therapeutic Targets
  The Mpox virus (MPXV), a zoonotic pathogen from the Orthopoxvirus genus, has emerged as a significant global public health concern, especially after the unprecedented outbreak in 2022. This review synthesizes the MPXV’s molecular features, focusing on its geno…
  openalex Edgar Cambaza 2025-01-16 置信度 0.72 Evasion (ethics)Immune systemGenomicsBiologyFunctional genomics
• Darwin: A Hardware-acceleration Framework for Genomic Sequence Alignment
  ABSTRACT Genomics is set to transform medicine and our understanding of life in fundamental ways. But the growth in genomics data has been overwhelming - far outpacing Moore’s Law. The advent of third generation sequencing technologies is providing new insight…
  openalex Yatish Turakhia, Kevin Jie Zheng, Gill Bejerano, William J. Dally 2017-01-15 置信度 0.72 SpeedupComputer scienceGenomicsDarwin (ADL)Hardware acceleration
• SWI/SNF Complex-Deficient Undifferentiated Carcinoma of the Pancreas: Clinicopathologic and Genomic Analysis
  openalex Aslihan Yavas, Kerem Özcan, Volkan Adsay, Serdar Balcı 等 2024-07-31 置信度 0.72 PathologyHematopathologyPancreasMedicineCarcinoma
• Genomic and Experimental Analysis of the Biostimulant and Antagonistic Properties of Phytopathogens of Bacillus safensis and Bacillus siamensis
  The B. safensis RGM 2450 and B. siamensis RGM 2529 strains were isolated from the rhizosphere of plants presenting resilience to abiotic and biotic stress conditions. To understand the implications of bacteria in resilience, a genomic and experimental analysis…
  openalex Fabiola Altimira, Sebastián Godoy, Matías Arias-Aravena, Bárbara Araya 等 2022-03-22 置信度 0.72 BiologyRhizosphereFusarium oxysporumInoculationBotany
• Twelve New Genomic Loci Associated With Bone Mineral Density
  Aiming to identify more genomic loci associated with bone mineral density (BMD), we conducted a joint association analysis of 2 genome-wide association study (GWAS) by the integrative association method multi-trait analysis of GWAS (MTAG). The first one is the…
  openalex Lu Liu, Min Zhao, Zonggang Xie, Ju Liu 等 2020-04-22 置信度 0.72 Genome-wide association studyQuantitative trait locusExpression quantitative trait lociGenetic associationLocus (genetics)
• Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling
  openalex Isabelle F. Foote, Jonny P Flint, Anna E. Fürtjes, Jeremy M Lawrence 等 2025-08-01 置信度 0.72 BiologyMultivariate statisticsStructural equation modelingGenetic architectureMultivariate analysis
• Genomic Epidemiology of West Nile Virus in Paris
  Importance: West Nile virus (WNV), a mosquito-borne orthoflavivirus, represents an increasing public health threat in Europe. In July 2025, WNV lineage 2 (WNV-L2) was associated with the first autochthonous cases ever detected in the metropolitan area around P…
  openalex Raphaelle Klitting, Mathilde Gondard, Laura Pezzi, Camille Victoire Migné 等 2026-02-16 置信度 0.72 Biological dispersalWest Nile virusBiologyVirologyEpidemiology
• Report of the 47th annual conference and the golden jubilee year meeting of the Environmental Mutagen Society of India (EMSI) and international conference on environmental and molecular mutagenesis: genomic integrity and implication to human health, Tamil Nadu, India, January 29–31, 2025
  The 47th Annual Conference and the Golden Jubilee Year Meeting of the Environmental Mutagen Society of India (EMSI) and International Conference on Environmental and Molecular Mutagenesis: Genomic Integrity and Implication to Human Health was held at the Depar…
  openalex Bani Bandana Ganguly 2025-04-25 置信度 0.72 MutagenPolitical scienceLibrary scienceBiotechnologyBiology
• Genomics in plant pathogen identification and control
  Recent advances in genomics have revolutionized plant pathogen detection and control by enabling faster and more accurate identification compared to traditional culture-based methods. Genomic tools like metagenomics and next generation sequencing (NGS) facilit…
  openalex Nkechi Gloria Ogbuji, Josephine U. Agogbua 2025-11-05 置信度 0.72 BiologyGenomicsCRISPRMetagenomicsIdentification (biology)
• The genomic and cellular basis of biosynthetic innovation in rove beetles
  openalex Sheila A. Kitchen, Thomas H. Naragon, Adrian Brückner, Mark S. Ladinsky 等 2024-06-17 置信度 0.72 BiologyComputational biologyBiotechnologyGenetics
• Kolmogorov–Arnold networks for genomic tasks
  Kolmogorov-Arnold networks (KANs) emerged as a promising alternative for multilayer perceptrons (MLPs) in dense fully connected networks. Multiple attempts have been made to integrate KANs into various deep learning architectures in the domains of computer vis…
  openalex Oleksandr Cherednichenko, Maria Poptsova 2025-03-01 置信度 0.72 Computer scienceGenomic medicineComputational biologyArtificial intelligenceBiology
• The International Weed Genomics Consortium: Community Resources for Weed Genomics Research
  Abstract The International Weed Genomics Consortium is a collaborative group of researchers focused on developing genomic resources for the study of weedy plants. Weeds are attractive systems for basic and applied research due to their impacts on agricultural …
  openalex Jacob S. Montgomery, Sarah Morran, Dana R. MacGregor, J. Scott McElroy 等 2023-07-20 置信度 0.72 WeedGenomicsAgricultureWeed controlSelection (genetic algorithm)
• MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG
  Abstract Reactive oxygen species (ROS) oxidize nucleotide triphosphate pools (e.g., 8-oxodGTP), which may kill cells if incorporated into DNA. Whether cancers avoid poisoning from oxidized nucleotides by preventing incorporation via the oxidized purine diphosp…
  openalex Sean G. Rudd, Helge Gad, Kumar Sanjiv, Nuno Amaral 等 2020-04-20 置信度 0.72 MitosisDNA damageBiologyDNA replicationMitotic catastrophe
• The genomic history of East Asian Middle Neolithic millet- and rice-agricultural populations
  The Yellow and Yangtze river basins in China are among the world's oldest independent agricultural centers, known for the domestication of millet and rice, respectively, yet their genetic history is poorly understood. Here, we present genome-wide data from 74 …
  openalex Jianxue Xiong, Xu Yu, Guoke Chen, Liping Yang 等 2025-08-19 置信度 0.72 AgricultureMiddle EastGeographyAncient historyAgronomy
• Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example
  The current paradigm of personalized medicine envisages the use of genomic data to provide predictive information on the health course of an individual with the aim of prevention and individualized care. However, substantial efforts are required to realize the…
  openalex Bram P. Prins, Liis Leitsalu, Katri Pärna, Krista Fischer 等 2021-04-29 置信度 0.72 Personalized medicinePrecision medicineGenomic medicineData scienceHealth care
• Genomic evidence for low genetic diversity but purging of strong deleterious variants in snow leopards
  BACKGROUND: Long-term persistence of species with low genetic diversity is the focus of widespread attention in conservation biology. The snow leopard, Panthera uncia, is a big cat from high-alpine regions of Asia. However, its subspecies taxonomy, evolutionar…
  openalex Lin Yang, Hongjian Jin, Qi‐En Yang, Andrey D. Poyarkov 等 2025-04-14 置信度 0.72 BiologyHuman geneticsEvolutionary biologyGeneticsGenetic diversity
• Understanding variants of unknown significance and classification of genomic alterations
  Despite recent efforts to issue clinical guidelines outlining strategies to define the pathogenicity of genomic variants, there is currently no standardized framework for which to make these assertions. This review does not present a step-by-step methodology, …
  openalex Dean C. Pavlick, Garrett M. Frampton, Jeffrey R Ross 2024-05-30 置信度 0.72 Context (archaeology)Computational biologyPathogenicityScope (computer science)Perspective (graphical)
• Comprehensive genomic profiling of over 10,000 advanced solid tumors
  // Jean-Paul De La O 1 , Jess R. Hoag 1 , Angela K. Deem 1 , Min Wang 1 , Arthur Starodynov 1 , Sameer S. Udhane 1 , Janine R. LoBello 1 , Nishitha Therala 1 , David W. Hall 1 , Gargi D. Basu 1 and Frederick L. Baehner 1 1 Exact Sciences Corporation, Madison, …
  openalex Jean-Paul De La O, Jess Hoag, Angela K. Deem, Min Wang 等 2025-07-25 置信度 0.72 MedicineSolid tumorInternal medicineProstate cancerOncology
• Evaluating the Cost of Genomic Testing for Biomarker-Driven Therapies in Oncology
  INTRODUCTION: Genomic profiling is used in the diagnosis, monitoring, and treatment of malignancies. Comprehensive genomic profiling (CGP) is a next-generation sequencing (NGS) approach that can test multiple genes simultaneously, potentially saving time, mone…
  openalex Jamie Partridge Grossman, Elizabeth A. Sheppard, Zhuofan Yan, Magdalene Crabbe 等 2026-02-18 置信度 0.72 MedicineCalculatorPrecision oncologyPrecision medicineClinical Practice
• Genomic rearrangements of hMSH6 contribute to the genetic predisposition in suspected hereditary non-polyposis colorectal cancer syndrome: Figure 1
  BACKGROUND: Germline mutations in mismatch repair genes, mainly in hMLH1, hMSH2, and hMSH6, predispose to the hereditary non-polyposis colorectal cancer (HNPCC) syndrome. A substantial fraction of these mutations exists in genomic rearrangements of hMSH2 and h…
  openalex Jens Plaschke, J Rüschoff, H K Schackert 2003-08-01 置信度 0.72 ExonBiologyGeneticsGermlineGermline mutation
• Repeatability of evolution and genomic predictions of temperature adaptation in seed beetles
  Climate warming is threatening biodiversity by increasing temperatures beyond the optima of many ectotherms. Owing to the inherent non-linear relationship between temperature and the rate of cellular processes, such shifts towards hot temperature are predicted…
  openalex Alexandre Rêgo, Julian Baur, Camille Girard‐Tercieux, Maria de la Paz Celorio‐Mancera 等 2025-05-16 置信度 0.72 RepeatabilityAdaptation (eye)BiologyEvolutionary biologyBiological system
• Dosage-sensitive miRNAs trigger modulation of gene expression during genomic imbalance in maize
  The genomic imbalance caused by varying the dosage of individual chromosomes or chromosomal segments (aneuploidy) has more detrimental effects than altering the dosage of complete chromosome sets (ploidy). Previous analysis of maize (Zea mays) aneuploids revea…
  openalex Xiaowen Shi, Hua Yang, Chen Chen, Jie Hou 等 2022-05-31 置信度 0.72 microRNABiologyGene dosageGeneAneuploidy
• The Origins of Coca: Museum Genomics Reveals Multiple Independent Domestications from ProgenitorErythroxylum gracilipes
  Coca is the natural source of cocaine as well as a sacred and medicinal plant farmed by South American Amerindians and mestizos. The coca crop comprises four closely related varieties classified into two species (Amazonian and Huánuco varieties within Erythrox…
  openalex Dawson M. White, Jen‐Pan Huang, Orlando Adolfo Jara-Muñoz, Santiago Madriñán 等 2020-09-17 置信度 0.72 DomesticationCocaBiologyAmazon rainforestAmazonian
• JARVIS3: an efficient encoder for genomic data
  MOTIVATION: Large-scale genomic projects grapple with the complex challenge of reducing medium- and long-term storage space and its associated energy consumption, monetary costs, and environmental footprint. RESULTS: We present JARVIS3, an advanced tool engine…
  openalex Maria J P Sousa, Armando J. Pinho, Diogo Pratas 2024-11-28 置信度 0.72 Computer scienceData compressionCompression (physics)ComputationMemory footprint
• Genomics‐driven prophylactic measures to increase streptococcosis resistance in tilapia
  Streptococcosis caused by Streptococcus agalactiae and S. iniae is a significant problem that affects the success of tilapia aquaculture industries worldwide. In this critical review, we summarize the applicable practical strategies which may effectively enhan…
  openalex Pattanapon Kayansamruaj, Nguyen Dinh‐Hung, Prapansak Srisapoome, Uthairat Na‐Nakorn 等 2023-01-28 置信度 0.72 TilapiaBiologyAquacultureGenomicsBiotechnology
• CRISPRi-ART enables functional genomics of diverse bacteriophages using RNA-binding dCas13d
  Bacteriophages constitute one of the largest reservoirs of genes of unknown function in the biosphere. Even in well-characterized phages, the functions of most genes remain unknown. Experimental approaches to study phage gene fitness and function at genome sca…
  openalex Benjamin A. Adler, Muntathar Al-Shimary, Jaymin R. Patel, Emily G. Armbruster 等 2025-02-26 置信度 0.72 BiologyGeneCRISPRGenomeFunctional genomics
• Whose Odyssey Is It? Family‐Centered Care in the Genomic Era
  Despite a century of progress in medical knowledge, many diagnostic odysseys end in disappointment, especially when the child has a developmental disorder. In cases of autism and intellectual disability, relatively few children receive a specific diagnosis, an…
  openalex Jeffrey P. Brosco 2018-07-01 置信度 0.72 DisappointmentMedical diagnosisExome sequencingIntellectual disabilityPsychology
• Genomics identifies koala populations at risk across eastern Australia
  Koalas are an iconic, endangered, Australian marsupial. Disease, habitat destruction, and catastrophic mega-fires have reduced koalas to remnant patches of their former range. With increased likelihood of extreme weather events and ongoing habitat clearing acr…
  openalex Elspeth A. McLennan, Toby G. L. Kovacs, Luke W. Silver, Zhiliang Chen 等 2024-11-29 置信度 0.72 Phascolarctos cinereusBiologyEcologyRange (aeronautics)Habitat
• The Cost Effectiveness of Genomic Medicine in Cancer Control: A Systematic Literature Review
  BACKGROUND AND OBJECTIVE: Genomic medicine offers an unprecedented opportunity to improve cancer outcomes through prevention, early detection and precision therapy. Health policy makers worldwide are developing strategies to embed genomic medicine in routine c…
  openalex Mackenzie Bourke, Aideen McInerney‐Leo, Julia Steinberg, Tiffany Boughtwood 等 2025-03-29 置信度 0.72 MedicinePersonalized medicineCINAHLCost effectivenessMEDLINE
• Genomic characteristics and epidemic trends of NADC30-like PRRSV in China
  BACKGROUND: NADC30-like PRRSV was first identified in China in 2012 and had become the predominant circulating strain since 2016. Currently, the recombination patterns of NADC30-like PRRSV in China exhibit a high degree of complexity, characterized by low whol…
  openalex Siyu Zhang, Xu Hu, Zhenyang Guo, Lirun Xiang 等 2025-05-28 置信度 0.72 GenBankGeneticsBiologyPhylogenetic treeRecombination
• An Overview of the Molecular Mechanisms of Recombinational DNA Repair
  Recombinational DNA repair is a universal aspect of DNA metabolism and is essential for genomic integrity. It is a template-directed process that uses a second chromosomal copy (sister, daughter, or homolog) to ensure proper repair of broken chromosomes. The k…
  openalex Stephen C. Kowalczykowski 2015-11-01 置信度 0.72 BiologyMolecular geneticsGeneticsDNADNA repair
• The Role of Genomics in Advancing and Standardising Bacteriophage Therapy
  Bacteriophage therapy, which employs bacterial viruses to selectively eliminate pathogenic bacteria, has re-emerged as a promising strategy in the face of increasing antimicrobial resistance. However, its widespread clinical implementation is constrained by co…
  openalex Narina Abdraimova, Egor Shitikov, Maria Kornienko 2026-01-04 置信度 0.72 Phage therapyBacteriophageComputational biologyGenomicsBiology
• Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases
  Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect several million individuals worldwide. Crohn's disease and ulcerative colitis are complex diseases that are heterogeneous at the clinical, immunological, molecular, genet…
  openalex Jason Lloyd‐Price, Cesar Arze, Ashwin N. Ananthakrishnan, Melanie Schirmer 等 2019-05-29 置信度 0.72 Inflammatory Bowel DiseasesOmicsGut floraInflammatory bowel diseaseEcosystem
• Terpenoid biomaterials
  Terpenoids (isoprenoids) encompass more than 40 000 structures and form the largest class of all known plant metabolites. Some terpenoids have well-characterized physiological functions that are common to most plant species. In addition, many of the structural…
  openalex Jörg Bohlmann, Christopher I. Keeling 2008-05-01 置信度 0.72 TerpenoidContext (archaeology)Biochemical engineeringChemistryBiology
• Epstein-Barr virus BRLF1 induces genomic instability and progressive malignancy in nasopharyngeal carcinoma cells
  // Sheng-Yen Huang 1 , Chung-Chun Wu 1 , Yu-Jhen Cheng 1 , Sheng-Ping Chou 1 , Yun-Jin Jiang 2 , Kuo-Chang Chu 2 , Ching-Hwa Tsai 3 , Su-Fang Lin 1 and Jen-Yang Chen 1, 3 1 National Institute of Cancer Research, National Health Research Institutes, Miaoli 3505…
  openalex Sheng‐Yen Huang, Chung-Chun Wu, Yu-Jhen Cheng, Sheng‐Ping Chou 等 2017-09-05 置信度 0.72 Nasopharyngeal carcinomaGenome instabilityMalignancyEpstein–Barr virusCancer research
• Genomics Define Malignant Transformation in Myeloma Precursor Conditions
  Multiple myeloma (MM) is consistently preceded by monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). While these precursor conditions are asymptomatic, they are not entirely benign and carry a lifelong risk of prog…
  openalex Francesco Maura, P. Leif Bergsagel, Bachisio Ziccheddu, Shaji Kumar 等 2025-10-08 置信度 0.72 Multiple myelomaMalignant transformationMonoclonal gammopathy of undetermined significanceGenomicsMedicine
• Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood
  openalex Yasminka A. Jakubek, Xiaolong Ma, Adrienne M. Stilp, Fulong Yu 等 2025-01-13 置信度 0.72 BiologyGeneticsPhenotypeHaplotypeAllele
• Genomic epidemiology analysis of drug-resistant Mycobacterium tuberculosis distributed in Mexico
  Genomics has significantly revolutionized pathogen surveillance, particularly in epidemiological studies, the detection of drug-resistant strains, and disease control. Despite its potential, the representation of Latin American countries in the genomic catalog…
  openalex Paulina M. Mejía‐Ponce, Elsy Janeth Ramos-González, Axel Alejandro Ramos-García, Edgar E. Lara‐Ramírez 等 2023-10-13 置信度 0.72 Mycobacterium tuberculosisDrug resistanceTuberculosisBiologyGenotype
• Epstein–Barr virus infection and nasopharyngeal carcinoma
  Epstein-Barr virus (EBV) is associated with multiple types of human cancer, including lymphoid and epithelial cancers. The closest association with EBV infection is seen in undifferentiated nasopharyngeal carcinoma (NPC), which is endemic in the southern Chine…
  openalex Sai Wah Tsao, Chi Man Tsang, Kwok Wai Lo 2017-09-11 置信度 0.72 Nasopharyngeal carcinomaLytic cycleEpstein–Barr virusBiologyVirus
• WheatGP, a genomic prediction method based on CNN and LSTM
  Wheat plays a crucial role in ensuring food security. However, its complex genetic structure and trait variation pose significant challenges for breeding superior varieties. In this study, a genomic prediction method for wheat (WheatGP) is proposed. WheatGP is…
  openalex Chunying Wang, Di Zhang, Yuexin Ma, Yonghao Zhao 等 2025-03-01 置信度 0.72 Computer scienceConvolutional neural networkArtificial intelligenceEpistasisRegression
• Population genomics analyses reveal the role of hybridization in the rapid invasion of fall armyworm
  INTRODUCTION: Invasive species pose a major threat to global biodiversity and agricultural productivity, yet the genomic mechanisms driving their rapid expansion into new habitats are not fully understood. The fall armyworm, Spodoptera frugiperda, originally f…
  openalex Xuan Wang, Zhenyong Du, Yuange Duan, Shanlin Liu 等 2024-09-30 置信度 0.72 Population genomicsGenomicsBiologyPopulationComputational biology
• Inference of Population Splits and Mixtures from Genome-Wide Allele Frequency Data
  Many aspects of the historical relationships between populations in a species are reflected in genetic data. Inferring these relationships from genetic data, however, remains a challenging task. In this paper, we present a statistical model for inferring the p…
  openalex Joseph K. Pickrell, Jonathan K. Pritchard 2012-11-15 置信度 0.72 BiologyDomesticationEvolutionary biologyInferencePopulation
• The Genomic Signature of Population Reconnection Following Isolation: From Theory to HIV
  Ease of worldwide travel provides increased opportunities for organisms not only to colonize new environments but also to encounter related but diverged populations. Such events of reconnection and secondary contact of previously isolated populations are widel…
  openalex Nicolas Alcala, Jeffrey D. Jensen, Amalio Telenti, Séverine Vuilleumier 2015-11-10 置信度 0.72 Coalescent theoryBiologyPopulationEvolutionary biologyDemographic history
• Nivolumab plus Ipilimumab in Advanced Non–Small-Cell Lung Cancer
  BACKGROUND: In an early-phase study involving patients with advanced non-small-cell lung cancer (NSCLC), the response rate was better with nivolumab plus ipilimumab than with nivolumab monotherapy, particularly among patients with tumors that expressed program…
  openalex Matthew D. Hellmann, Luis Paz‐Ares, Reyes Bernabe Caro, Bogdan Żurawski 等 2019-09-28 置信度 0.72 NivolumabIpilimumabMedicineLung cancerOncology