-
Abstract Aging research has been advanced largely through the use of model organisms, where short lifespans and genetic tractability enable the systematic discovery of molecular pathways influencing longevity and age-related decline. However, knowledge about a…
preprints
2026
置信度 0.86
cs.aibiologypsychologyartificial intelligencecomputational biology
-
Abstract Background : Pathogen surveillance is vital for managing infectious diseases in Africa, where high disease burdens necessitate advanced tools like genomics and bioinformatics. While these technologies enable early detection, resistance monitoring, and…
preprints
2025
置信度 0.81
-
Genetic studies leveraging natural variation in Arabidopsis species have improved our understanding of evolutionary genetic processes underlying ecologically important and adaptive traits. Integrating the thorough functional knowledge accumulated in A. thalian…
preprints
2026
置信度 0.81
-
Cell-free expression systems (CFE) are flexible protein translation platforms that simplify the central dogma into an accessible reaction space. Within these systems, bulk transfer RNAs (tRNAs) are critical substrates which deliver amino acids to the elongatin…
preprints
2025
置信度 0.81
-
Single-cell RNA sequencing (scRNA-seq) cell annotation techniques rely on the matching of known defining marker genes to a given cell population. However, these methods may lack robustness to dynamic fluctuations in cell marker expression between patients, sam…
preprints
2026
置信度 0.86
cs.lgbiologycomputational biologycomputer scienceq-bio.qm
-
Amyloid fibrils are highly ordered, aggregation-prone protein assemblies implicated in numerous neurodegenerative diseases. Their formation arises from protein misfolding, producing structurally distinct polymorphs that have historically been difficult to pred…
preprints
2025
置信度 0.81
-
Metabolic modeling enables the prediction of functional capabilities in organisms and microbial communities from genomic data. However, current workflows for genome-scale metabolic model (GEM) reconstruction and contextualization remain time-consuming and tech…
preprints
2025
置信度 0.81
-
ABSTRACT Precise temporal control of protein expression is essential for dissecting protein function and dynamic cellular processes. We present a framework for engineering tunable oscillatory protein expression (repeated pulses in expression) using widely adop…
preprints
2025
置信度 0.81
-
Protein function is governed by molecular interactions, yet structural coverage of these interactions remains sparse. The AlphaFold Protein Structure Database (AFDB) transformed access to accurate monomeric protein structures at scale. Here, we expand the AFDB…
preprints
2026
置信度 0.86
biologyq-bio.bmcomputational biologycs.lgpharmacology
-
Background Seasonal human influenza viruses can escape from antibody-mediated neutralization when amino acid changes occur in the hemagglutinin protein. Routine surveillance identified circulation of an A(H3N2) virus variant in the Netherlands with amino acid …
preprints
2026
置信度 0.77
-
Nervous systems display extensive diversity in structure and organization, yet a broadly conserved set of signaling pathway components and transcription factors is consistently associated with early neurogenesis in many animal lineages. Determining how these c…
preprints
2026
置信度 0.81
-
Microbial symbionts play pivotal roles in the physiology, ecology, and evolution of insects. While obligate symbionts have been extensively characterized in insects feeding on nutritionally poor diets, the diversity and functional roles of facultative bacteria…
preprints
2025
置信度 0.81
-
Bioscience encompasses studies on living organisms, their components, and their interactions, with the main aim of translating research into useful applications for medical, clinical, industrial, and environmental uses. The broad field of bioscience has witnes…
preprints
2025
置信度 0.81
-
Live-cell imaging (LCI) captures dynamic cellular behaviours missed in fixed samples. Researchers in resource-limited settings are underrepresented in the adoption of LCI due to the prohibitive cost of dedicated systems. We adapted the 3D-printed OpenFlexure M…
preprints
2026
置信度 0.81
-
Vocal accommodation is the process by which individuals adjust their vocalizations to resemble those of social partners. This phenomenon is widespread in social animals and can reinforce affiliation, signal group identity, and facilitate coordination. Most stu…
preprints
2026
置信度 0.77
-
A central goal of ecology is understanding how the architecture of food webs, which represent the structural backbone of ecosystems, affects their stability. The analysis of stability in the classical sense of population dynamics (i.e. return to equilibrium) c…
preprints
2026
置信度 0.81
-
Free-air warming systems are essential for simulating climate change in field conditions, yet most are not designed to meet UK or EU health and safety standards. We present the design and field deployment of a hexagonal Temperature-Free Air Controlled Enhancem…
preprints
2026
置信度 0.81
-
Plasmodium falciparum is the major cause of malaria in Africa, responsible for high morbidity and mortality across the continent. This study presents a systematic literature review and bibliometric analysis of P. falciparum research conducted in Africa between…
preprints
2025
置信度 0.81
-
Abstract Despite the increasing prevalence of urban agriculture, the diversity, composition, and antimicrobial resistance (AMR) profiles ( i.e. , resistome) of microbial communities in rooftop and surface garden soils remain poorly characterized in Bangladesh,…
preprints
2026
置信度 0.81
-
Abstract Bacterial chromosome biology has largely focused on bacteria that are either free-living or facultatively associated with eukaryotes. Therefore, it is not known how obligate animal symbionts organize their chromosomes. Here, we studied the chromosome …
preprints
2026
置信度 0.81
-
Although strict maternal transmission of mitochondria is a general feature of animals for ensuring homogeneity in mitochondrial DNA (mtDNA) across generations, exceptions were reported in the recent past. For example, some extremely rare but spectacular cases …
preprints
2026
置信度 0.86
biologygeologyastrobiologyphysics.bio-phmeteorite
-
Mitosis depends on precise spindle assembly and positioning, processes influenced by cell shape, size, and microenvironment. Most mechanistic insights into mitosis come from two-dimensional (2D) monolayer cultures, which lack the spatial constraints and extrac…
preprints
2026
置信度 0.81
-
To what extent conserved developmental programs specify homologous cell types is a central question in biology. Here, we address this by focusing on reconstructing monoaminergic neuron development in Drosophila melanogaster embryo using time- resolved single-c…
preprints
2025
置信度 0.86
biologygeneticsmedicinepharmacologypsychology
-
The transporting epithelial tissues comprising the Drosophila melanogaster alimentary and renal systems are known to share a common set of enriched genes sometimes referred to as the "epitheliome", reflecting their shared transport functions. Core amongst thes…
preprints
2026
置信度 0.81
-
Although the use of accelerometer-based behavioural classification to quantify animal activity budgets is gaining widespread traction, the interactions between key preprocessing decisions and modern classification algorithms remain poorly understood. Moreover,…
preprints
2026
置信度 0.81
-
ABSTRACT DEAD-box RNA helicases remodel RNA structures in many cellular pathways, yet how their activity is spatially controlled in cells remains poorly understood. The Drosophila germline helicase Vasa functions in ovaries only when localized to cytoplasmic g…
preprints
2026
置信度 0.86
biologycell biologysynthetic biologycomputational biologyconsciousness
-
Abstract Ongoing global warming and intensified human disturbance are projected to substantially alter future biome dynamics. However, robust prediction of such shifts requires long-term, spatially extensive datasets to evaluate model performance. Here, we int…
preprints
2026
置信度 0.81
-
Myeloid neoplasms (MN) are clonal heterogeneous disorders initiated by somatic driver mutations in hematopoietic stem and progenitor cells (HSPCs). Among the most common are mutations in RNA splicing factors, which exert pleiotropic effects but are difficult t…
preprints
2025
置信度 0.81
-
The recent MPXV epidemic across Africa revealed extensive viral diversity and complex transmission dynamics, prompting a continent-wide genomic investigation. We analysed 3,450 high-quality MPXV virus whole genomes from 24 African Union Member States, revealin…
preprints
2026
置信度 0.81
-
Three-dimensional electron microscopy (3D EM) enables the quantitative analysis of cellular ultrastructure. However, large-scale segmentation of whole-cell volumes poses a significant challenge, especially in biologically diverse systems. Unlike medical and an…
preprints
2026
置信度 0.86
computer scienceartificial intelligencecomputer and information sciencescs.lgcs.ai
-
The variety of cell phenotypes identified by single-cell technologies is rapidly expanding, yet this knowledge is dispersed across the scientific literature and incompletely represented in structured resources. We present the CellLink corpus, a manually annota…
preprints
2026
置信度 0.86
biologyq-bio.mnq-bio.qmcomputational biologycell biology
-
Accurate long-term forecasting of cognitive trajectories across the Alzheimer’s disease continuum is essential for early intervention, personalized prognosis, patient stratification, and clinical trial enrichment. Despite the promising predictive performance o…
preprints
2026
置信度 0.86
cs.lgcs.aiartificial intelligencecomputer and information sciencesmedicine
-
The emergence of virtual human twins (VHT) in biomedical research has sparked interest in multiscale in silico modelling frameworks, particularly in their application bridging cellular to tissue levels. Among the diverse array of multiscale modelling tools, of…
preprints
2025
置信度 0.86
computer sciencedata sciencebiologymedicinepsychology
-
Migration is a ubiquitous process that links ecosystems with distinct seasonal dynamics, transferring biomass and species interactions across space. Despite being widely altered by global change, studies commonly overlook the interaction of seasonal characteri…
preprints
2025
置信度 0.81
-
Mesoscopic functional brain mapping is essential to better understanding of various brain functions and dysfunctions. However, accessing distributed neural circuits in mammalian brain regions remains a significant challenge. While fiber photometry is a versati…
preprints
2025
置信度 0.86
cs.lgneurosciencecs.cvq-bio.ncneuroimaging
-
Transfer RNAs (tRNAs) are utilized by the ribosome to decode the nucleic acid alphabet. tRNA structure, stability, aminoacylation efficiency, and decoding efficacy are governed by their extensive post-transcriptional modifications. In most studies, individual …
preprints
2025
置信度 0.81
-
Cell-free expression systems (CFES) are increasingly used alongside conventional biotechnological approaches to accelerate early-stage prototyping and are particularly valuable in point-of-use settings. However, their broader adoption remains limited by time- …
preprints
2026
置信度 0.86
synthetic biologybiochemistrygeneticsecologybiology
-
Ribonucleotide reductases (RNRs) catalyze the conversion of ribonucleotide (RNA) to deoxyribonucleotide (DNA) building blocks initiated by a long-range (>30 Å) proton-coupled electron transfer (PCET) by mechanistic principles that remain much debated. By combi…
preprints
2026
置信度 0.81
-
Network neuroscience has significantly advanced our understanding of how structural and functional connectivity evolve during healthy neurocognitive aging. Yet, integrative studies linking structural and functional brain organization with cognitive performance…
preprints
2025
置信度 0.86
psychologyneurosciencecognitive sciencecognitioncognitive neuroscience
-
The tight regulation of the integrin family of extracellular matrix (ECM) receptors is essential for the coordination of most cellular processes. Talin regulates integrin function by binding to the cytoplasmic tail of the integrin beta subunit. Two integrin-bi…
preprints
2026
置信度 0.86
cell biologyphysics.chem-phdrug discoverygeologycs.ai
-
Escherichia coli sequence type (ST) 131 is the most widely studied genetic lineage of the species to date, originally identified in the early 2000s as an increasingly common cause of human urinary tract and bloodstream infections worldwide. This lineage is sub…
preprints
2025
置信度 0.86
biologypsychologygeologyneurosciencemars exploration program
-
The leap from laboratory to marketplace represents the critical chasm in longevity technology innovation. While scientific breakthroughs in aging biology continue to accelerate (López-Otín et al., 2023; DePinho et al., 2024), the commercialization pathway rema…
preprints
2025
置信度 0.81
-
Given the accumulation of evidence that evolution can affect ecological dynamics, especially under global change scenarios, a key question is how such ecoevolutionary dynamics may change the coexistence of species and biodiversity in general. In the present ar…
preprints
2026
置信度 0.81
-
Phenotypic screening is a powerful technology to discover drug candidates in physiologically relevant systems without prior knowledge of molecular targets; however, mass spectrometry (MS) remains underutilised as readout strategy. In this proof-of-concept stud…
preprints
2025
置信度 0.81
-
Biological systems are composed of multiple molecular layers, including the genome, epigenome, transcriptome, and metabolome. These layers are interconnected and interact, but are often studied independently. Multi-omics approaches aim to integrate these layer…
preprints
2025
置信度 0.86
psychologymedicinebiologycognitionbiotechnology
-
Transient Receptor Potential Melastatin 2 (TRPM2), a Ca²⁺-permeable cation channel, regulates innate and adaptive immunity and has recently been implicated in vitiligo, an autoimmune pigmentary disorder. However, whether TRPM2 exerts cell-autonomous immunoregu…
preprints
2026
置信度 0.81
-
Expression of the Csf1r gene in cells of the mononuclear phagocyte lineage is regulated by a conserved enhancer, the fms-intronic regulatory element (FIRE). In mice with a germ-line deletion of FIRE ( Fireko ) CSF1R expression is undetectable in bone marrow pr…
preprints
2026
置信度 0.81
-
ABSTRACT Turing’s longstanding reaction-diffusion hypothesis explains how molecular patterns can self-organize de novo in otherwise homogeneous tissues. However, whilst simple Turing models can qualitatively recapitulate patterning in silico , they are often h…
preprints
2025
置信度 0.81
-
Recombination is a fundamental evolutionary process essential for generating genetic diversity, facilitating adaptation, and driving speciation. However, direct measurement of recombination rate remains challenging, as standard methods—such as chiasma counts o…
preprints
2025
置信度 0.81
-
Environmental surveillance for human pathogen detection is crucial for safeguarding public health; however, traditional approaches are often time-consuming, equipment-intensive and workflow-complex, delaying actionable public-health decision-making. The integr…
preprints
2026
置信度 0.82
medicinecomputer sciencepsychologybiologysociology
-
Viral infection of living cells, exemplified by bacteriophage interaction with bacteria, is fundamental to biology and universal across living systems. Here, we establish an all-cell-free viral cycle where T7 phages infect synthetic cells, equipped with lipopo…
preprints
2025
置信度 0.81
-
Advances in microscopy and bioimage analysis are enabling unprecedented quantitative observation of dynamic biological systems. Smart microscopy closes the loop by feeding back image-derived information to control image acquisition on the fly, paving the way f…
preprints
2025
置信度 0.81
-
Whole-genome duplication (WGD) is widespread in plants, yet the extent to which it yields predictable phenotypic outcomes remains unclear. Here we show that the phenotypic consequences of genome doubling in a duckweed model system, Spirodela polyrhiza , are hi…
preprints
2026
置信度 0.77
-
Fibrotic encapsulation around medical implants affects millions of patients annually. Current approaches targeting inflammation or implant material properties have failed clinically, but the mechanical origins of implant-induced fibrosis remain unexplored. Her…
preprints
2025
置信度 0.81
-
C-type lectins (CTLs) play key roles in innate immunity and microbial carbohydrate recognition. In the disease vector mosquito Aedes aegypti , the CTLD-S family comprises 34 soluble CTLs whose members are implicated in flavivirus dissemination and microbial ho…
preprints
2026
置信度 0.86
biologyphysics.bio-phq-bio.bmcomputational biologyq-bio.qm
-
Quantifying the abundance and activity of bacteria within populations and communities is fundamental to systems microbiology and microbiome research. Yet direct microscopic cell counting remains low-throughput, labor-intensive, and prone to user variability, l…
preprints
2026
置信度 0.86
biologyecologybiological sciencesq-bio.qmbiological sciences not elsewhere classified
-
Root growth angle is a key determinant of root system architecture, nutrient capture efficiency and therefore yield. Yet the mechanisms governing non-vertical growth in cereal roots remain poorly understood. Here, we investigated if cereal roots maintain Gravi…
preprints
2026
置信度 0.81
-
ABSTRACT Plants rely on specialized metabolites to defend against herbivores, yet how root-associated symbiotic microbes influence their regulation, coordination, and overall contribution to defense remains widely unknown. We hypothesized that symbiotic microb…
preprints
2026
置信度 0.81
-
Light is essential for photosynthetic organisms, but excess light can generate toxic levels of reactive oxygen species (ROS). To neutralize these ROS, plants and algae produce a variety of antioxidants like carotenoids, tocopherols, and glutathione. However, t…
preprints
2026
置信度 0.81
-
Abstract Bogong moths (Agrotis infusa) migrate biannually up to 1,000 km between their breeding areas and geographically restricted aestivation sites in the Australian Alps 1,2 . These moths navigate towards their distant goal using the stars as a compass 3 bu…
preprints
2026
置信度 0.77
physicsastrophysicsastronomyphysical sciencesastro-ph.sr
-
Abstract Background Cardiovascular diseases remain the leading cause of death globally, with age as the primary risk factor. Unlike chronological age, biological age aims to capture age-related physiological changes and may better predict health outcomes and d…
preprints
2026
置信度 0.86
medicinebiologypsychologydiseaseneuroscience
-
Single-cell proteomics (SCP) reveals cellular heterogeneity and biological insights inaccessible to bulk analysis. Existing limitations are cost, sample loss during processing, and accessibility to state-of-the-art instrumentation. We describe a label free SCP…
preprints
2026
置信度 0.81
-
Selective auditory attention decoding (sAAD) enables neuro-steered hearing devices by identifying the attended speaker in a multi-speaker environment from neural activity recorded with electroencephalography (EEG). Despite algorithmic progress, practical deplo…
preprints
2026
置信度 0.81
-
Predicting plant mixture overyielding from functional traits is central to understanding how biodiversity influences ecosystem functioning. Combining empirical data from a large mixture experiment (764 mixtures) and two trait-measurement experiments containing…
preprints
2026
置信度 0.81
-
Abstract Helminth-driven immunomodulation contributes to immune heterogeneity in tropical environments. Whether it can be reversed by BCG revaccination, an inducer of trained immunity, remains unknown. We applied high-dimensional mass cytometry to profile immu…
preprints
2026
置信度 0.82
medicinepsychologybiologysociologymedline
-
ABSTRACT The origin of meiotic sex was a key milestone in the evolution of the eukaryotic cell. The DNA recombinases Rad51 and DMC1 have been used previously to trace the timing and origins of the meiotic machinery, and warrant revisiting in the face of the re…
preprints
2025
置信度 0.81
-
Many animals communicate using sequences of signals, but identifying recurrent, non-random signal combinations remains methodologically challenging. Collocation analyses are increasingly popular approaches for detecting which signals animals combine at rates g…
preprints
2026
置信度 0.77
-
ABSTRACT Eukaryotic cells change their shapes, actively segregate their DNA and contain membrane networks, facilitated by a complex cytoskeleton containing actin filaments, microtubules made from tubulin, and other components. These filaments have ancient evol…
preprints
2026
置信度 0.86
biologyastrobiologyastro-ph.epcomputational biologygeology
-
Neural oscillations play a crucial role in cognition, and several studies emphasize the importance of considering them as traveling waves that propagate through brain regions. In scalp EEG, waves typically travel along the anterior–posterior axis: forward wave…
preprints
2026
置信度 0.81
-
Abstract Background Malaria causes high morbidity and mortality in Sudan. Conflict and displacement have disrupted control efforts, likely increasing disease transmission. This study explored malaria epidemiology, parasite distribution, hematological changes, …
preprints
2026
置信度 0.81
-
Background Apolipoprotein E4 ( APOE4 ) is the strongest common genetic risk factor for late-onset Alzheimer’s disease and has been implicated in cerebrovascular dysfunction. Vascular endothelial growth factor receptor 2 (VEGFR2), encoded by the gene KDR , is a…
preprints
2026
置信度 0.86
medicinecell biologybiologybiotechnologyneuroscience
-
The accelerating growth of plant science literature presents a major challenge for researchers seeking to extract accurate, up-to-date knowledge from an increasingly fragmented and domain-specific corpus. General-purpose large language models (LLMs), while pow…
preprints
2025
置信度 0.86
cs.aicomputer sciencedata scienceinterpretabilitycs.cl
-
Polyploidy is a widespread phenomenon in flowering plants, with up to 30% of extant species being recent polyploids. Whether and how polyploidy modulates the action of natural selection remains debated, and the particular case of balancing selection has been p…
preprints
2025
置信度 0.77
-
During direct communication between two cells, the plasma membranes of each cell serve as a platform for ligand-receptor interaction initiating downstream signalling cascades. In immune cell signalling, this cell-cell interface – the immune synapse – is highly…
preprints
2025
置信度 0.81
-
Abstract Background Metabolic resistance is widespread in Anopheles gambiae malaria vectors, and is largely driven by overexpression and/or mutation of detoxification enzymes such as cytochrome P450. However, the fitness costs of these mechanisms and the impac…
preprints
2026
置信度 0.81
-
To behave adaptively in the environment and select appropriate responses to sensory stimuli, animals integrate learnt information about the valences of stimuli with contextual information. While significant progress has been made in understanding how animals l…
preprints
2025
置信度 0.82
neurosciencepsychologycontextartificial intelligencecognitive science
-
ABSTRACT PlantCV is an open-source Python project aimed at developing tools to address a range of image-based, plant phenotyping questions. PlantCV has been used for more than 10 years to automate trait collection from image data and the newest release, PlantC…
preprints
2025
置信度 0.77
computer sciencebiologyartificial intelligencecs.cvcomputational biology
-
Medulloblastoma, the most common malignant pediatric brain tumor, arises from developmental aberrations of cerebellar precursor cells. The CUL3-RING ubiquitin ligase adaptor KBTBD4 is recurrently mutated in medulloblastoma subgroups 3 and 4. While KBTBD4 mutat…
preprints
2026
置信度 0.81
-
Zipf’s law of brevity is a widespread manifestation of information compression found across human languages and other communication systems. Chimpanzee gesture represents a rare absence of its expression in short-range communication. But, whether this absence …
preprints
2025
置信度 0.81
-
In Bilateria with centralized nervous systems (e.g. in vertebrates or arthropods), the minimum of the BMP signaling activity gradient defines the position of the central nervous system. BMP-dependent patterning of the secondary body axis is ancestral for Bilat…
preprints
2025
置信度 0.81
-
Defective social behavior and cognitive functions are hallmarks of Autism spectrum disorders (ASD). The molecular mechanisms keeping social behavior in a physiological range are largely unknown. We recently found that conditional knockout (cKO) of tmiRNA clust…
preprints
2026
置信度 0.86
psychologyneurosciencemedicine and health sciencesbiologycognitive psychology
-
Essential nuclear processes require pairs of chromosomal loci to find each other in three-dimensional space. Polymer models of chromosome dynamics typically assume that the stochastic forces driving such locus motion are spatially uncorrelated, implying that r…
preprints
2026
置信度 0.81
-
The acidic blackwaters of Southeast Asia’s peat-swamp forests represent some of the most extreme freshwater environments on Earth. Despite their very low pH values, limited nutrients, and hypoxic conditions, these blackwater habitats harbor a remarkable divers…
preprints
2026
置信度 0.81
-
Quorum Sensing (QS) and Machine Learning (ML) hybrid systems represent a groundbreaking innovation in synthetic biology, offering unprecedented control and adaptability in microbial gene regulation and metabolic processes. QS, a microbial communication mechani…
preprints
2024
置信度 0.81
-
The choroid is critical for maintaining vision and implicated in several ocular diseases, being the sole source of nutrients and waste removal for the outer retina. Genetic discovery can help elucidate the pathways through which choroidal features influence di…
preprints
2026
置信度 0.77
-
Mechanistic accounts of brain function require a common coordinate system in which structural, molecular and functional data can be integrated and compared across individuals. The teleost genus Danionella is unique among vertebrates in retaining lifelong trans…
preprints
2026
置信度 0.86
neurosciencebiologyneuroimagingcognitive neurosciencecognitive science
-
Summary Photosynthesis, which sustains life on Earth, depends on organized and yet adaptable protein assemblies embedded in specialized membranes known as thylakoids. Understanding how these complexes interact and reorganize within functional photosynthetic me…
preprints
2025
置信度 0.81
-
Summary Diatoms are ubiquitous aquatic microalgae critical to our planet, that were amongst the pioneer model organisms in cell biology for their large and transparent cell structure. However, their robust silica cell wall renders diatoms impermeable to many d…
preprints
2025
置信度 0.81
-
Transmembrane proteins perform many crucial functions in the cell, including transfer of matter and information across the membrane. Giant Unilamellar Vesicles (GUVs) are the ideal tool for studying these processes; yet functional transmembrane protein reconst…
preprints
2025
置信度 0.81
-
Background: Clec9a (also named as DNGR-1), is a restricted DAMPs (Damage-Associated Molecular Patterns) receptor that recognizes cell death signals expressed on human BDCA3 + DC and mouse CD8α + and CD103 + DC. With the rapid advancement of immunology, numerou…
preprints
2025
置信度 0.81
-
Peripheral sensory neurons, residing in the dorsal root ganglia (DRG), relay sensory information from the periphery to the central nervous system. Although single-cell transcriptomic studies have identified over 20 distinct sensory neuron subtypes, functional …
preprints
2025
置信度 0.81
-
Cyclin-dependent kinase-like 5 (CDKL5) is a serine/threonine kinase essential for brain development and function. Mutations in the CDKL5 gene cause CDKL5 deficiency disorder (CDD), a severe early-onset epileptic encephalopathy characterised by defects in synap…
preprints
2025
置信度 0.81
-
ABSTRACT Spatially resolved omics technologies enable investigation of how cells interact within their local environments or neighbourhoods directly in situ . Although a few computational methods have been developed to aid this analysis, significant limitation…
preprints
2025
置信度 0.81
-
Spo11 initiates meiotic recombination by introducing programmed DNA double-strand breaks. DNA cleavage occurs via a topoisomerase-like mechanism involving hybrid active sites formed at the dimer interface. However, in contrast to its topoisomerase relative (To…
preprints
2026
置信度 0.81
-
Synopsis Background Globally, there is a large gap in our understanding of the prevalence, ecology and transmission dynamics of antibiotic resistance (ABR) in extensively reared ruminants, despite these animals contributing to the food chain and frequently sha…
preprints
2025
置信度 0.72
-
General-purpose language models generate fluent health reports that can fabricate derived clinical met-rics. In an illustrative comparison on identical two-week CGM and meal data, leading foundation models produced reports with invented MAGE values, inflated m…
preprints
2026
置信度 0.86
artificial intelligencemedicinepsychologycs.aiai safety
-
Endogenous protein tagging in Caenorhabditis elegans enables direct visualization and manipulation of proteins in vivo, providing native readouts of expression, localization, and dynamics. No coordinated effort currently exists to comprehensively tag proteins …
preprints
2025
置信度 0.81
-
Mitochondrial proteome reconstruction from eukaryotic sequence data typically relies on prediction of mitochondrial targeting signals (MTSs). However, MTS predictors are primarily trained on model organisms and may perform poorly in phylogenetically divergent …
preprints
2026
置信度 0.72
-
Motivation The Encyclopedia of Domains (TED) provides domain annotations for proteins in the AlphaFold Protein Structure Database (AFDB) using a consensus of three state-of-the-art structure-based methods. We used these TED domain annotations to construct prof…
preprints
2026
置信度 0.81
-
Plant nucleotide-binding domain leucine-rich repeat-containing (NLR) proteins act as intracellular immune receptors that assemble into resistosomes to execute immune responses. However, the subcellular processes during cell death following resistosome activati…
preprints
2025
置信度 0.81