-
This chapter displays genomics analysis with an emphasis on next-generation sequencing (NGS), and annotation of bacterial genomes. It uncovers the underlying principles of dideoxy sequencing and selected next-generation sequencing technologies. The chapter als…
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pubmed
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openalex
Ruedi Aebersold, Matthias Mann
2003-03-01
置信度 0.72
ProteomeProteomicsComputational biologySystems biologyMass spectrometry
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The ExPASy (the Expert Protein Analysis System) World Wide Web server (http://www.expasy.org), is provided as a service to the life science community by a multidisciplinary team at the Swiss Institute of Bioinformatics (SIB). It provides access to a variety of…
openalex
Elisabeth Gasteiger
2003-06-25
置信度 0.72
UniProtProteomicsBiologyWeb serverService (business)
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The PRoteomics IDEntifications (PRIDE) database (https://www.ebi.ac.uk/pride/) is the world's largest data repository of mass spectrometry-based proteomics data. PRIDE is one of the founding members of the global ProteomeXchange (PX) consortium and an ELIXIR c…
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Yasset Pérez‐Riverol, Jingwen Bai, Chakradhar Bandla, David García‐Seisdedos 等
2021-10-16
置信度 0.72
PrideProteomicsMetadataIdentifierUniProt
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Recent developments in the field of proteomics have revolutionized the way that proteins, and their contribution to cellular functions, are studied. The subsequent increased understanding of the mechanisms of cellular function and misfunction will have particu…
openalex
John M. Walker
2005-01-01
置信度 0.72
Computer scienceProteomeProteomicsData scienceComputational biology
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openalex
Stefka Tyanova, Tikira Temu, Jüergen Cox
2016-10-27
置信度 0.72
Computer scienceShotgun proteomicsWorkflowProteomicsProtocol (science)
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SUMMARY: Skyline is a Windows client application for targeted proteomics method creation and quantitative data analysis. It is open source and freely available for academic and commercial use. The Skyline user interface simplifies the development of mass spect…
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Brendan MacLean, Daniela M. Tomazela, Nicholas Shulman, Matthew Chambers 等
2010-02-09
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openalex
Christine Vogel, Edward M. Marcotte
2012-03-13
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BiologyProteomeProteomicsTranscriptomeComputational biology
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Matthew Chambers, Brendan MacLean, Robert Burke, Dario Amodei 等
2012-10-01
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ProteomicsComputer scienceVendorApplication programming interfaceInterface (matter)
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Quantitative proteomics has traditionally been performed by two-dimensional gel electrophoresis, but recently, mass spectrometric methods based on stable isotope quantitation have shown great promise for the simultaneous and automated identification and quanti…
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Shao‐En Ong, Blagoy Blagoev, Irina Kratchmarova, Dan Bach Kristensen 等
2002-05-01
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Stable isotope labeling by amino acids in cell cultureQuantitative proteomicsProteomicsAmino acidProteome
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Emanuel F. Petricoin, Ali M. Ardekani, Ben A. Hitt, Peter J. Levine 等
2002-02-01
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Ovarian cancerComputational biologyCancerBiologyMedicine
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openalex
Akhilesh Pandey, Matthias Mann
2000-06-01
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ProteomicsComputational biologyBiologyFunction (biology)Genome
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Juri Rappsilber, Matthias Mann, Yasushi Ishihama
2007-08-01
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PhosphopeptideChromatographyPipetteMass spectrometryChemistry
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openalex
Tom Sargent
1988-05-01
置信度 0.72
Computational biologyCurrent (fluid)BiologyPhysicsThermodynamics
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Preface The Enteric Bacterial Cell and the Age of Bacteria Variations on a Theme by Escherichia Part I: Molecular Architecture and Assembly of Cell Parts (11 chapters) Part II: Metabolism and General Physiology (58 chapters) Part III: Utilization of Energy for…
openalex
Frederick C. Neidhardt
1996-01-01
置信度 0.72
Escherichia coliBiologySalmonellaBacteriaGenetics
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openalex
R.K. Dudley
1988-09-26
置信度 0.72
CitationLibrary sciencePublishingComputer scienceInformation retrieval
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openalex
1988-08-01
置信度 0.72
Computational biologyBiologyCurrent (fluid)Evolutionary biologyPhysics
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openalex
Francis Crick
1970-08-01
置信度 0.72
Nucleic acidComputational biologyResidue (chemistry)Structural biologyBiology
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Abstract Summary: The Biopython project is a mature open source international collaboration of volunteer developers, providing Python libraries for a wide range of bioinformatics problems. Biopython includes modules for reading and writing different sequence f…
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Peter Cock, Tiago Antão, Jeffrey T. Chang, Brad Chapman 等
2009-03-20
置信度 0.72
Python (programming language)MIT LicenseComputer scienceDocumentationSource code
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openalex
Timothy W. Short
2001-01-01
置信度 0.72
BiologyComputational biologyBiochemistry
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Since its publication in 2000, Biochemistry & Molecular Biology of Plants, has been hailed as a major contribution to the plant sciences literature and critical acclaim has been matched by global sales success. Maintaining the scope and focus of the first edit…
openalex
2001-03-01
置信度 0.72
Presentation (obstetrics)Scope (computer science)Section (typography)RestructuringCell and molecular biology
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Neuronal growth cones navigate over long distances along specific pathways to find their correct targets. The mechanisms and molecules that direct this pathfinding are the topics of this review. Growth cones appear to be guided by at least four different mecha…
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Marc Tessier‐Lavigne, Corey S. Goodman
1996-11-15
置信度 0.72
PathfindingAxon guidanceGrowth coneNeuroscienceBiology
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2023-02-14T20:25:14Z
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Miguel Ángel Medina Torres
2012-11-20T13:15:10Z
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2012-10-25T12:27:36Z
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This chapter provides an overview of the biochemical properties of RNA, including the versatility of its structure that enables a multitude of RNA molecules and functions in cells. It describes different types of RNA-binding domains that have evolved, and the …
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David Elliott, Michael Ladomery
2023-09-15T12:37:24Z
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2017-12-10T14:33:52Z
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2004-10-30T14:25:44Z
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2004-10-24T03:07:07Z
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2004-10-24T03:07:07Z
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Praise for the first edition: … superb, beautifully written and organized work that takes an engineering approach to systems biology. Alon provides nicely written appendices to explain the basic mathematical and biological concepts clearly and succinctly witho…
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Uri Alon
2019-07-12
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BiologyEvolutionary biology
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2002-12-14T12:14:32Z
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2002-12-14T14:42:57Z
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openalex
Hiroaki Kitano
2002-11-01
置信度 0.72
Systems biologyComputer scienceSystems medicineSynthetic biologyModular design
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MOTIVATION: Molecular biotechnology now makes it possible to build elaborate systems models, but the systems biology community needs information standards if models are to be shared, evaluated and developed cooperatively. RESULTS: We summarize the Systems Biol…
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Michael Hucka, Andrew Finney, Herbert M. Sauro, Hamid Bolouri 等
2003-02-28
置信度 0.72
SBMLMarkup languageSystems biologyComputer scienceXML
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openalex
Simeone Marino, Ian B. Hogue, Christian J. Ray, Denise E. Kirschner
2008-04-21
置信度 0.72
Sensitivity (control systems)Computer scienceMathematical modelParameter spaceVariety (cybernetics)
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The natural environment for plants is composed of a complex set of abiotic stresses and biotic stresses. Plant responses to these stresses are equally complex. Systems biology approaches facilitate a multi-targeted approach by allowing one to identify regulato…
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Grant R. Cramer, Kaoru Urano, Serge Delrot, Mario Pezzotti 等
2011-01-01
置信度 0.72
BiologyOrganismAbiotic componentAbiotic stressSystems biology
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A common challenge in the analysis of genomics data is trying to understand the underlying phenomenon in the context of all complex interactions taking place on various signaling pathways. A statistical approach using various models is universally used to iden…
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Sorin Drăghici, Purvesh Khatri, Adi L. Tarca, K. Amin 等
2007-09-04
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Systems biologyBiologyPathway analysisContext (archaeology)False positive paradox
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Quantitative computational models play an increasingly important role in modern biology. Such models typically involve many free parameters, and assigning their values is often a substantial obstacle to model development. Directly measuring in vivo biochemical…
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Ryan N. Gutenkunst, Joshua J. Waterfall, Fergal Casey, Kevin Brown 等
2007-09-28
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Statistical physicsEconometricsSensitivity (control systems)Systems biologyComputer science
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openalex
Nicolas Le Novère, Michael Hucka, Huaiyu Mi, Stuart Moodie 等
2009-08-01
置信度 0.72
Computer scienceNotationSBMLSystems biologyRepresentation (politics)
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Increased reliance on computational approaches in the life sciences has revealed grave concerns about how accessible and reproducible computation-reliant results truly are. Galaxy http://usegalaxy.org, an open web-based platform for genomic research, addresses…
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Jeremy Goecks, Anton Nekrutenko, James Taylor, The Galaxy Team
2010-08-25
置信度 0.72
Human geneticsBiologyGenome BiologyComputational biologyData science
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In the last two decades, the widespread application of genetic and genomic approaches has revealed a bacterial world astonishing in its ubiquity and diversity. This review examines how a growing knowledge of the vast range of animal-bacterial interactions, whe…
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Margaret McFall‐Ngai, Michael G. Hadfield, Thomas C. G. Bosch, Hannah V. Carey 等
2013-02-07
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BiologyAnimal lifeDiversity (politics)Environmental ethicsEcology
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openalex
2013-05-25
置信度 0.72
Computational biologyBiologyEvolutionary biologyChemistry
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MassBank is the first public repository of mass spectra of small chemical compounds for life sciences (<3000 Da). The database contains 605 electron-ionization mass spectrometry (EI-MS), 137 fast atom bombardment MS and 9276 electrospray ionization (ESI)-MS(n)…
openalex
Hisayuki Horai, Masanori Arita, Shigehiko Kanaya, Yoshito Nihei 等
2010-07-01
置信度 0.72
ChemistryMass spectrometryMass spectrumElectrospray ionizationDatabase
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The Bioperl project is an international open-source collaboration of biologists, bioinformaticians, and computer scientists that has evolved over the past 7 yr into the most comprehensive library of Perl modules available for managing and manipulating life-sci…
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Jason Stajich, David E. Block, Kris Boulez, Steven E. Brenner 等
2002-10-01
置信度 0.72
PerlComputer sciencePython (programming language)Scripting languageInteroperation
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openalex
Raymond B. Cattell
1978-01-01
置信度 0.72
Behavioural sciencesFactor (programming language)PsychologyComputer sciencePsychotherapist
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A recursive analysis of network and institutional evolution is offered to account for the decentralized structure of the commercial field of the life sciences. Four alternative logics of attachment - accumulative advantage, homophily, follow-the-trend, and mul…
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Walter W. Powell, Dougľas R. White, Kenneth W. Koput, Jason Owen‐Smith
2005-01-01
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HomophilyCommercializationField (mathematics)Dynamics (music)Network dynamics
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openalex
David R. Anderson
2007-12-20
置信度 0.72
InferencePrimer (cosmetics)Computer scienceData sciencePhilosophy of science
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openalex
Lihong V. Wang, Junjie Yao
2016-07-28
置信度 0.72
Photoacoustic imaging in biomedicinePhotoacoustic tomographyOptical imagingComputer sciencePreclinical imaging
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openalex
The Bioconda Team, Björn Grüning, Ryan Dale, Andreas Sjödin 等
2018-06-25
置信度 0.72
Computational biologySoftwareComputer scienceDistribution (mathematics)Data science
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The calcium ion (Ca<sup>2+</sup>) is a versatile intracellular messenger. It provides dynamic regulation of vast array of cellular processes such as gene transcription, differentiation and contraction. Ca<sup>2+</sup> signals range from…
openalex
Bootman, Martin, Lipp, Peter
2001-05-30
置信度 0.72
EncyclopediaLibrary scienceComputer science
-
Near infrared (NIR) multiphoton microscopy is becoming a novel optical tool of choice for fluorescence imaging with high spatial and temporal resolution, diagnostics, photochemistry and nanoprocessing within living cells and tissues. Three-dimensional fluoresc…
openalex
Karsten König
2000-11-01
置信度 0.72
Two-photon excitation microscopyMicroscopyFluorophoreFluorescencePicosecond
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2002-12-14T17:38:53Z
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2003-07-12T02:16:19Z
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2012-10-09T21:17:24Z
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2002-12-14T17:14:32Z
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2002-12-14T17:14:32Z
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pubmed
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2026
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pubmed
Abuzied Y, Mahmud A, Al-Amer R, Halain AA 等
2026
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pubmed
Thomas JL, Barbano AC, Fox AB, Stucchi S 等
2026 Sep
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pubmed
Davari Z, Zamiran S, Ganji L, Amini M 等
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pubmed
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pubmed
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pubmed
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pubmed
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To understand biology at the system level, we must examine the structure and dynamics of cellular and organismal function, rather than the characteristics of isolated parts of a cell or organism. Properties of systems, such as robustness, emerge as central iss…
openalex
Hiroaki Kitano
2002-03-01
置信度 0.72
Systems biologyRobustness (evolution)Systems medicineOrganismComputer science