合成生物与生物制造

10000 条实体 · 最后更新 2026-08-31T14:45:24.188Z · Metabolic flux analysis / Metabolic engineering / Metabolic pathway / Metabolic network / Flux (metallurgy) / Heterologous / Protein engineering / Computational biology / Secondary metabolism / Pollinator / Biology / Polyhydroxyalkanoates

• Nature Inspired Small Molecules for Chemical Biology
  Abstract Chemical biology and drug discovery are instrumental sciences to address unmet medical needs and to gain a deeper understanding of normal and disease state biology in mammalian systems. Unlike most genetic tools, the small molecule modulation of biolo…
  openalex Kamal Kumar, Herbert Waldmann 2018-10-18 置信度 0.72 Chemical biologyChemical spaceSmall moleculeNatural productDrug discovery
• Programming Next‐Generation Synthetic Biosensors by Genetic Circuit Design
  Synthetic biology employs engineering principles to construct genetic circuits with customized functionality, empowering unprecedented control over biological systems. By harnessing this capability to precisely manipulate biological systems, synthetic biosenso…
  openalex Yuanli Gao, Cheng Huang, Jiaxuan Deng, Lei Wang 等 2026-02-08 置信度 0.72 Synthetic biologyBiosensorComputer scienceNanotechnologyBioproduction
• Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.
  Human melanoma cell line MZ2-MEL expresses several antigens recognized by autologous cytolytic T lymphocyte (CTL) clones. We reported previously the identification of a gene, named MAGE-1, that codes for one of these antigens named MZ2-E. We show here that ant…
  openalex Béatrice Gaugler, Benoı̂t Van den Eynde, Pierre van der Bruggen, Pedro Romero 等 1994-03-01 置信度 0.72 CTL*AntigenBiologyExonHuman leukocyte antigen
• An outlook on structural biology after A lpha F old: tools, limits and perspectives
  AlphaFold and similar groundbreaking, AI-based tools, have revolutionized the field of structural bioinformatics, with their remarkable accuracy in ab-initio protein structure prediction. This success has catalyzed the development of new software and pipelines…
  openalex Serena Rosignoli, Maddalena Pacelli, Francesca Manganiello, Alessandro Paiardini 2024-09-23 置信度 0.72 Context (archaeology)Computer scienceStructural bioinformaticsField (mathematics)Software
• Status and Prospects of Botanical Biopesticides in Europe and Mediterranean Countries
  Concerning human and environmental health, safe alternatives to synthetic pesticides are urgently needed. Many of the currently used synthetic pesticides are not authorized for application in organic agriculture. In addition, the developed resistances of vario…
  openalex Fatma Acheuk, Shereen Basiouni, Awad A. Shehata, Katie Dick 等 2022-02-15 置信度 0.72 BiopesticidePesticideCrop protectionAgricultureBiotechnology
• DASH : a versatile and high‐capacity gene stacking system for plant synthetic biology
  DNA assembly systems based on the Golden Gate method are popular in synthetic biology but have several limitations: small insert size, incompatibility with other cloning platforms, DNA domestication requirement, generation of fusion scars, and lack of post-ass…
  openalex Chengsong Zhao, Anna N. Stepanova, José M. Alonso 2025-06-10 置信度 0.72 BiologyDashStackingComputational biologyGene
• Novel Insights into the Biotechnological Production of Haematococcus pluvialis-Derived Astaxanthin: Advances and Key Challenges to Allow Its Industrial Use as Novel Food Ingredient
  Astaxanthin shows many biological activities. It has acquired a high economic potential and its current market is dominated by its synthetic form. However, due to the increase of the health and environmental concerns from consumers, natural forms are now prefe…
  openalex Samuel Jannel, Yanis Caro, Marc Bermudes, Thomas Petit 2020-10-10 置信度 0.72 Haematococcus pluvialisAstaxanthinIngredientPluvialisBiotechnology
• The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
  openalex Steven E. Kahn 2003-01-01 置信度 0.72 Insulin resistanceType 2 diabetesInsulinInternal medicineEndocrinology
• Plastics and insects: Records of ants entangled in synthetic fibres
  Abstract Plastic pollution is an emerging environmental risk, as it may negatively impact many species. However, much remains to be studied in terrestrial invertebrates, since the information in which this pollutant interacts with insects and soil fauna in nat…
  openalex Álvaro Luna, Armand Rausell‐Moreno, J. Manuel Vidal‐Cordero 2023-09-18 置信度 0.72 LasiusHymenopteraBiologyFaunaEcology
• Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease.
  Alzheimer's Disease (AD) is the most common of the senile dementias, the prevalence of which is increasing rapidly, with a projected 14 million affected worldwide by 2025. The signal transduction mechanisms that underlie the learning and memory derangements in…
  openalex Kelly T. Dineley, Marcus A. Westerman, Duc Thien Bui, Karen A. Bell 等 2001-06-15 置信度 0.72 MAPK/ERK pathwayDownregulation and upregulationCREBProtein kinase ASignal transduction
• Bacterial Cellulose for Sustainable Food Packaging: Production Pathways, Structural Design, and Functional Modification Strategies
  Global concern over food waste and plastic pollution highlights the urgent need for sustainable, high-performance materials that can replace petroleum-based plastics. Bacterial cellulose (BC), a biopolymer synthesized through microbial fermentation by Komagata…
  openalex Ronagul Turganova, Rysgul N. Tuleyeva, Ayaz M. Belkozhayev, Nargiz N. Gizatullina 等 2025-11-28 置信度 0.72 Bacterial celluloseCelluloseBiopolymerBiochemical engineeringEnvironmental science
• Synthetic photorespiratory bypass more stably increases potato yield per plant by improving photosynthesis
  The bioengineering of photorespiration has emerged as a key target for improving photosynthesis and crop yield. In our previous study, two photorespiratory bypasses, GOC and GCGT, were successfully established in rice, and the transgenic plants exhibited incre…
  openalex Xiu-Ling Lin, Yuming Long, Zhen Yao, Boran Shen 等 2025-04-02 置信度 0.72 PhotorespirationPhotosynthesisBiologyYield (engineering)Agronomy
• Advanced Materials From Fungal Mycelium: Fabrication and Tuning of Physical Properties
  In this work is presented a new category of self-growing, fibrous, natural composite materials with controlled physical properties that can be produced in large quantities and over wide areas, based on mycelium, the main body of fungi. Mycelia from two types o…
  openalex Muhammad Haneef, Luca Ceseracciu, Claudio Canale, Ilker S. Bayer 等 2017-01-24 置信度 0.72 MyceliumCelluloseChitinPolysaccharidePleurotus ostreatus
• Designing Tunable DNA Condensates to Control Membrane Budding Transformation in Synthetic Cells
  Wetting interactions between biomolecular condensates and lipid membranes have demonstrated great potential to induce large-scale membrane transformations in synthetic cells. However, the ability to functionalize existing condensates and control their interact…
  openalex Nastasja Kaletta, Sophia Burick, Yusuf Qutbuddin, Petra Schwille 2025-06-27 置信度 0.72 MembraneWettingVesicleNanotechnologyLinker
• Overexpression of glut-1 glucose transporter in human breast cancer an immunohistochemical study
  BACKGROUND: Breast cancers have higher than normal glucose metabolism, but the mechanism of glucose entry into these tumors is not well understood. METHODS: The expression of five facilitative glucose transporters, Glut-1 (erythrocyte type), Glut-2 (liver type…
  openalex Raya S. Brown, Richard L. Wahl 1993-11-15 置信度 0.72 Glucose transporterImmunohistochemistryBreast cancerMedicineGlucose Transporter Type 1
• Exploring the world of small proteins in plant biology and bioengineering
  Small proteins are ubiquitous in all kingdoms of life. MicroProteins, initially characterized as small proteins with protein interaction domains that enable them to interact with larger multidomain proteins, frequently modulate the function of these proteins. …
  openalex Louise Petri, Anne Van Humbeeck, Huanying Niu, Casper Ter Waarbeek 等 2024-10-14 置信度 0.72 BiologyComputational biologyFunction (biology)Sequence homologyHomology (biology)
• Modulation of Protein–Protein Interactions with Molecular Glues in a Synthetic Condensate Platform
  Misregulation of protein-protein interactions (PPIs) underlies many diseases; hence, molecules that stabilize PPIs, known as molecular glues, are promising drug candidates. Identification of novel molecular glues is highly challenging among others because clas…
  openalex Thijs W. van Veldhuisen, Renske M. J. Dijkstra, Auke A. Koops, Peter J. Cossar 等 2025-01-28 置信度 0.72 ChemistryModulation (music)BiophysicsCombinatorial chemistryComputational biology
• ortho ‐Boronic Acid Carbonyl Compounds and Their Applications in Chemical Biology**
  Iminoboronates and diazaborines are related classes of compounds that feature an imine ortho to an arylboronic acid (iminoboronate) or a hydrazone that cyclizes with an ortho arylboronic acid (diazaborine). Rather than acting as independent chemical motifs, th…
  openalex Jack G. Haggett, Dylan W. Domaille 2023-11-15 置信度 0.72 ImineHydrazoneBioconjugationChemistryBoronic acid
• Immunotherapy of prostate cancer using novel synthetic DNA vaccines targeting multiple tumor antigens
  Prostate cancer is a prevalent cancer in men and consists of both indolent and aggressive phenotypes. While active surveillance is recommended for the former, current treatments for the latter include surgery, radiation, chemo and hormonal therapy. It has been…
  openalex Devivasha Bordoloi, Peng Xiao, Hyeree Choi, Michelle Ho 等 2021-03-15 置信度 0.72 Prostate cancerMedicineImmunotherapyAntigenCancer
• AcuSim: A Synthetic Dataset for Cervicocranial Acupuncture Points Localisation
  The locations of acupuncture points (acupoints) differ among human individuals due to variations in factors such as height, weight and fat proportions. However, acupoint annotation is expert-dependent, labour-intensive, and highly expensive, which limits the d…
  openalex Qilei Sun, Jintan Ma, Paul Craig, Linjun Dai 等 2025-04-15 置信度 0.72 AcupunctureComputer scienceInformation retrievalMedicinePathology
• Synthetic peptides activating discoidin domain receptor 2 and collagen‐binding integrins cooperate to stimulate osteoblast differentiation of skeletal progenitor cells
  openalex Chunxi Ge, Yiming Li, Fashuai Wu, X. Peter 等 2023-05-27 置信度 0.72 OsteoblastIntegrinCell biologyDiscoidin domainCollagen receptor
• Cytotoxicity of natural and synthetic cannabinoids and their synergistic antiproliferative effects with cisplatin in human ovarian cancer cells
  Introduction Cannabinoids are reported to suppress the growth of ovarian cancer cells, but it is unclear whether structural modifications can improve their cytotoxic effects. Methods Herein, an investigation into the antiproliferative effects of natural cannab…
  openalex Ying Chen, Huifang Li, Jia‐Bao Liu, Jie Ni 等 2024-11-26 置信度 0.72 CytotoxicityCisplatinOvarian cancerSynthetic cannabinoidsPharmacology
• Enhancing melatonin biosynthesis in crops through synthetic genetic circuits: A strategy for nutritional fortification in soybean and stress resistance in cotton
  Melatonin has gained considerable prominence in the treatment of insomnia that significantly impacts one-third of the global population. The production of melatonin remains challenging due to limitations in current methods. Thus, there is an urgent need for de…
  openalex Yue Shi, Zegang Han, Wanying Zhang, Lu He 等 2025-07-07 置信度 0.72 BiologyMelatoninBiotechnologyPopulationAgronomy
• Xenotransplantation Literature Update: January–June 2025
  In the first half of 2026, xenotransplantation advanced through refinement rather than dramatic new clinical milestones. Clinical studies described graft physiology, immune infiltration, complement activation, coagulation incompatibility, and early function in…
  openalex Kasra Shirini, Joseph M. Ladowski, Niket Harsh, Raphaël Meier 2025-07-01 置信度 0.72 XenotransplantationBiologyMedicineComputational biologyTransplantation
• Detection of RNA modifications
  RNA nucleotide modifications are typically of low abundance and frequently go unnoticed by standard detection methods of molecular biology and cell biology. With a burst of knowledge intruding from such diverse areas as genomics, structural biology, regulation…
  openalex Stefanie Kellner, Jürgen Burhenne, Mark Helm 2010-03-01 置信度 0.72 BiologyComputational biologyNucleotideRNATranscriptome
• From Microbial Consortia to Ecosystem Resilience: The Integrative Roles of Holobionts in Stress Biology
  The holobiont paradigm, conceptualizing host–microbiome assemblages as functionally integrated entities, has fundamentally altered interpretations of adaptive responses to environmental pressures spanning multiple organizational levels. This review synthesizes…
  openalex Maximino Manzanera 2025-09-06 置信度 0.72 HolobiontBiologyEcologyMicrobiomeAdaptation (eye)
• Plant engineering: advances, bottlenecks, and promise
  Plant genetic engineering has transformed our ability to study gene function and improve crop performance, enabling innovations in agriculture, synthetic biology, and biotechnology. Advances in plant transformation technologies have made it possible to introdu…
  openalex Federica Brandizzí, Jenny C. Mortimer, Katherine Denby 2025-04-01 置信度 0.72 Environmental scienceBiochemical engineeringEngineering
• Engineering Multiple Abiotic Stress Tolerance in Canola, Brassica napus
  Impacts of climate change like global warming, drought, flooding, and other extreme events are posing severe challenges to global crop production. Contribution of Brassica napus towards the oilseed industry makes it an essential component of international trad…
  openalex Neeta Lohani, Divya Jain, Mohan B. Singh, Prem L. Bhalla 2020-02-25 置信度 0.72 CanolaBrassicaAbiotic stressAbiotic componentBiology
• The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo
  GPR55 is a G protein-coupled receptor recently shown to be activated by certain cannabinoids and by lysophosphatidylinositol (LPI). However, the physiological role of GPR55 remains unknown. Given the recent finding that the cannabinoid receptors CB(1) and CB(2…
  openalex Lauren S. Whyte, Erik Ryberg, Natalie A. Sims, Susan A. Ridge 等 2009-09-03 置信度 0.72 OsteoclastBone resorptionCannabinoid receptorChemistryCell biology
• The Chemistry and Biology of the Tetrodotoxin Natural Product Family
  Tetrodotoxin is a neurotoxic marine alkaloid, first isolated in 1909 from pufferfish and named after the biological order tetraodontiformes. Since its structural elucidation in 1964, it has attracted the interest of synthetic organic chemists due to its except…
  openalex Benedikt Nißl, Marcel Muelbaier, Francesca Grisoni, Dirk Trauner 等 2025-06-18 置信度 0.72 TetrodotoxinNatural productNatural (archaeology)Product (mathematics)Chemistry
• AI-driven multi-omics integration for multi-scale predictive modeling of genotype-environment-phenotype relationships
  Despite the wealth of single-cell multi-omics data, it remains challenging to predict the consequences of novel genetic and chemical perturbations in the human body. It requires knowledge of molecular interactions at all biological levels, encompassing disease…
  openalex You Wu, Lei Xie 2025-01-01 置信度 0.72 OmicsPhenotypeScale (ratio)Computational biologyGenotype
• Long, Synthetic Staphylococcus aureus Type 8 Capsular Oligosaccharides Reveal Structural Epitopes for Effective Immune Recognition
  High Resolution Image Download MS PowerPoint Slide Staphylococcus aureus is a Gram-positive bacterium that is responsible for severe nosocomial infections. The rise of multidrug-resistant strains, which can pose significant health threats, prompts the developm…
  openalex Kitt Emilie Østerlid, Charlotte Sorieul, Luca Unione, Sizhe Li 等 2025-01-10 置信度 0.72 ChemistryTrisaccharideGlycosidic bondEpitopeImmunogenicity
• An argument for using anaerobes as microbial cell factories to advance synthetic biology and biomanufacturing
  Abstract Anaerobes thrive in the absence of oxygen and are an untapped reservoir of biotechnological potential. Therefore, bioprospecting efforts focused on anaerobic microbial diversity could rapidly uncover new enzymes, pathways, and chassis organisms to dri…
  openalex Thomas S. Lankiewicz, Nathalie H. Elisabeth, David L. Valentine, Michelle O’Malley 2025-02-25 置信度 0.72 BioproductionBiomanufacturingBioprocessBiochemical engineeringBiotechnology
• Design and Immune Profile of Multi-Epitope Synthetic Antigen Vaccine Against SARS-CoV-2: An In Silico and In Vivo Approach
  BACKGROUND: The rapid advancement of the pandemic caused by SARS-CoV-2 and its variants reinforced the importance of developing easy-to-edit vaccines with fast production, such as multi-epitope DNA vaccines. The present study aimed to construct a synthetic ant…
  openalex Maria da Conceição Viana Invenção, Larissa Silva de Macêdo, Ingrid Andrêssa de Moura, Lucas Alexandre Barbosa de Oliveira Santos 等 2025-01-31 置信度 0.72 In silicoEpitopeVirologyImmune systemIn vivo
• Super‐Resolution Fluorescence Microscopy Methods for Assessing Mouse Biology
  Super-resolution (diffraction unlimited) microscopy was developed 15 years ago; the developers were awarded the Nobel Prize in Chemistry in recognition of their work in 2014. Super-resolution microscopy is increasingly being applied to diverse scientific field…
  openalex Jessica Valli, Jeremy Sanderson 2021-08-01 置信度 0.72 MicroscopySTED microscopyResolution (logic)Super-resolution microscopyFluorescence microscope
• Synthetic Biology Biosensors for Global Health Challenges
  Synthetic biologists seek to design, build and modify organisms at the genetic level. One category of engineered organisms, or devices, sense changes in the environment and respond by producing a change in state, such as colour. Two such ‘biosensors’ are in de…
  openalex Rob Smith, Claire Marris, Dominic Berry, Lalitha Sundaram 等 2017-05-03 置信度 0.72 Scope (computer science)Engineering ethicsGlobal healthPolitical scienceEngineering
• Strain Improvement Through Genetic Engineering and Synthetic Biology for the Creation of Microalgae with Enhanced Lipid Accumulation, Stress Tolerance, and Production of High-value
  Microalgae are microscopic, unicellular or simple colony-forming photosynthetic organisms found mainly in freshwater and marine environments. Unlike multicellular macroalgae, microalgae lack complex structures such as roots, stems, and leaves. They perform pho…
  openalex Alebachew Molla, Gedif Meseret Abebe 2025-08-27 置信度 0.72 Synthetic biologyStrain (injury)Lipid accumulationProduction (economics)Value (mathematics)
• Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs
  Multicomponent reactions (MCRs) have emerged as a powerful strategy in synthetic organic chemistry due to their widespread applications in drug discovery and development. MCRs are flexible transformations in which three or more substrates react to form structu…
  openalex Giovanni Graziano, Angela Stefanachi, Marialessandra Contino, Rubén Prieto‐Díaz 等 2023-04-01 置信度 0.72 Drug discoveryBiochemical engineeringCombinatorial chemistryIdentification (biology)Computational biology
• Self-driving laboratories, advanced immunotherapies and five more technologies to watch in 2025
  openalex Michael Eisenstein 2025-01-20 置信度 0.72 SustainabilityEngineeringEcologyBiology
• Cost-Benefit Analysis of Synthetic Nucleic Acid Screening for the UK - Report - CLTR 2025
  openalex Paul-Enguerrand Fady, Cassidy Nelson, Isaac Heron, Richard Bruns 2025-12-16 置信度 0.72 ChemistryNucleic acidBiochemistryDNABiology
• Multifaceted Applications of Microbial Pigments: Current Knowledge, Challenges and Future Directions for Public Health Implications
  Microbial oddities such as versatile pigments are gaining more attention in current research due to their widely perceived applications as natural food colorants, textiles, antimicrobial activities, and cytotoxic activities. This indicates that the future gene…
  openalex Chatragadda Ramesh, Nambali Valsalan Vinithkumar, R. Kirubagaran, Chidambaram Kulandaisamy Venil 等 2019-06-28 置信度 0.72 PathogenicityBiologyBiotechnologyBiochemical engineeringEngineering
• Fundamentals and Recent Developments in Approximate Bayesian Computation
  Bayesian inference plays an important role in phylogenetics, evolutionary biology, and in many other branches of science. It provides a principled framework for dealing with uncertainty and quantifying how it changes in the light of new evidence. For many comp…
  openalex Jarno Lintusaari, Michael U. Gutmann, Ritabrata Dutta, Samuel Kaski 等 2016-10-19 置信度 0.72 Approximate Bayesian computationInferenceBayesian inferenceBayesian probabilityComputer science
• Cholecystokinin: Clinical aspects of the new biology
  Cholecystokinin (CCK) is a classic gut hormone that has been known for almost a century to regulate gallbladder emptying, pancreatic enzyme secretion, and gastrointestinal motor activity. In 1968, the CCK structure was identified by Viktor Mutt and Erik Jorpes…
  openalex Jens F. Rehfeld 2025-06-25 置信度 0.72 CholecystokininHormoneEnteroendocrine cellParacrine signallingMedicine
• AI and Robotics in Agriculture: A Systematic and Quantitative Review of Research Trends (2015–2025)
  The swift integration of AI, robotics, and advanced sensing technologies has revolutionized agriculture into a data-centric, autonomous, and sustainable sector. This systematic study examines the interplay between artificial intelligence and agricultural robot…
  openalex Abderrachid Hamrani, A. Allouhi, Fatma Bouarab, K. Jayachandran 2025-10-21 置信度 0.72 Artificial intelligenceRoboticsField (mathematics)Computer scienceAgriculture
• Harnessing Small RNAs as Synthetic Post-transcriptional Regulators in Bacteria
  Bacteria can respond to environmental changes by expressing small RNAs (sRNAs), which regulate mRNAs by complementary base-pairing. This regulatory mechanism allows bacteria to rapidly adapt their proteome. In recent years, sRNAs have gained attention as bluep…
  openalex Jens Georg, Bork A. Berghoff, Daniel Schindler 2025-07-08 置信度 0.72 Synthetic biologyComputational biologyBacteriaBiologyGenetics
• Applications of Bioinformatics Tools in Medicinal Biology and Biotechnology
  Development of modern medicine necessitates the collection, integration and interpretation of molecular, genomic, and cellular data, together with clinical data. Hence, it produces a significant amount of challenges to bioinformatics. For the investigation and…
  openalex Harshil Shah, Vivek P. Chavda, Moinuddin Soniwala 2023-02-07 置信度 0.72 BiomedicineData scienceComputational biologyTranslational bioinformaticsBiological data
• Meiotic pairing irregularity and homoeologous chromosome compensation cause rapid karyotype variation in synthetic allotetraploid wheat
  Summary Allopolyploidization may initiate rapid evolution due to heritable karyotypic changes. The types and extents of these changes, the underlying causes, and their effects on phenotype remain to be fully understood. Here, we designed experimental populatio…
  openalex Jing Zhao, Juzuo Li, Ruili Lv, Bin Wang 等 2023-05-10 置信度 0.72 BiologyMeiosisGeneticsChromosomeKaryotype
• Harnessing apomixis: natural mechanisms and synthetic innovations for advancing crop and forage breeding
  Apomixis, a reproductive mechanism that enables clonal seed production, generates progeny genetically identical to the maternal parent. In plant breeding, sexual reproduction can enhance traits through genetic recombination and hybrid vigor, yet trait segregat…
  openalex Shuyi Hu, Xiaoyun Han, Lei Tian, Kejian Wang 等 2025-07-16 置信度 0.72 BiologyApomixisForageCropAgroforestry
• Sex‐specific behavioural, metabolic, and immunohistochemical changes after repeated administration of the synthetic cannabinoid AKB48 in mice
  Abstract Background and Purpose AKB48 is a synthetic cannabinoid illegally sold for its psychoactive cannabis‐like effects that have been associated with acute intoxication and whose effects are poorly known. Experimental Approach Using a behavioural, neuroche…
  openalex Giorgia Corli, E. Roda, Micaela Tirri, Sabrine Bilel 等 2023-12-27 置信度 0.72 CannabinoidCannabinoid receptorNeurochemicalInternal medicineEndocrinology
• A Review of Recent Progress in Synthetic Polymer Surface Coatings for the Prevention of Biofilm Formation
  Bacterial adhesion and the subsequent formation of biofilms and biofouling have significant economic and health impacts across all sectors. They are especially impactful in industrial corrosion, healthcare, food processing, agriculture, and waste and drinking …
  openalex Adrienne Shea, Matthew T. Bernards 2025-06-24 置信度 0.72 BiofoulingBiofilmAdhesionPolymerNanotechnology
• Recent advances in 3D bioprinting of vascularized tissues
  3D bioprinting is a technology that combines computing science, biology and material engineering. It has been extensively explored to fabricate 3D vascularized constructs for tissue engineering. This scalable, reproducible and highly precise fabrication techno…
  openalex Yi Zhang, Piyush Kumar, Songwei Lv, Di Xiong 等 2020-12-10 置信度 0.72 3D bioprintingBiofabricationTissue engineeringNanotechnologyMaterials science
• A synthetic model of bioinspired liposomes to study cancer-cell derived extracellular vesicles and their uptake by recipient cells
  Extracellular vesicles (EVs) are secreted by most cell types and play a central role in cell-cell communication. These naturally occurring nanoparticles have been particularly implicated in cancer, but EV heterogeneity and lengthy isolation methods with low yi…
  openalex Rubén R. López, Chaymaa Zouggari Ben El Khyat, Yunxi Chen, Thupten Tsering 等 2025-03-11 置信度 0.72 LiposomeExtracellular vesiclesVesicleCell biologyCancer cell
• Cell-Membrane-Anchored Synthetic Dynamic DNA Circuits for Signaling Transient Cell Migration
  in which each includes the antimesenchymal epithelial transition (Met) receptor aptamer sequence is anchored within MCF-7 cells to emulate the natural signaling network on the live cell membrane. Subjecting the membrane-integrated circuit to an auxiliary fuel …
  openalex Nina Lin, Yu Ouyang, Yunlong Qin, Songqin Liu 等 2025-09-12 置信度 0.72 ChemistryBiophysicsIntracellularTransient (computer programming)DNA
• antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation
  Microorganisms synthesize small bioactive compounds through their secondary or specialized metabolism. Those compounds play an important role in microbial interactions and soil health, but are also crucial for the development of pharmaceuticals or agrochemical…
  openalex Kai Blin, Simon J. Shaw, Lisa Vader, Judit Szenei 等 2025-04-17 置信度 0.72 Nonribosomal peptideBiologyGene clusterGenomeComputational biology
• The Human Plastiphere: A Bioparticulate System Challenging Microplastic Risk Assessment and Governance
  The infiltration of microplastics (MPs) into human tissues represents a paradigm shift in environmental health, transforming external pollution into internal biological integration. Drawing on 90 clinical studies (2016-2025), we define the human plastiphere as…
  openalex Shruti Venkata Chari, Gurusamy Kutralam-Muniasamy 2025-10-01 置信度 0.72 MicroplasticsRisk analysis (engineering)Risk assessmentHuman healthCorporate governance
• Nanomaterials for Neural Interfaces
  Abstract This review focuses on the application of nanomaterials for neural interfacing. The junction between nanotechnology and neural tissues can be particularly worthy of scientific attention for several reasons: (i) Neural cells are electroactive, and the …
  openalex Nicholas A. Kotov, Jessica O. Winter, Isaac P. Clements, Edward Jan 等 2009-07-09 置信度 0.72 InterfacingNanotechnologyMaterials scienceNanomaterialsNeural Prosthesis
• BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality
  The discovery ofBRCA1andBRCA2as tumor susceptibility genes and their role in genome maintenance has transformed our understanding of hereditary breast and ovarian cancer. This review traces the evolution of BRCA1/2 research over the past 30 years, highlighting…
  openalex Anna Khalizieva, Sarah C. Moser, Peter Bouwman, Jos Jonkers 2024-11-07 置信度 0.72 BiologySynthetic lethalityLethalityBRCA2 ProteinCancer
• Quantitative Measurement of Molecular Permeability to a Synthetic Bacterial Microcompartment Shell System
  Naturally evolved and synthetically designed forms of compartmentalization benefit encapsulated function by increasing local concentrations of substrates and protecting cargo from destabilizing environments and inhibitors. Crucial to understanding the fundamen…
  openalex Eric J. Young, Henning Kirst, Matthew E. Dwyer, Josh V. Vermaas 等 2025-01-14 置信度 0.72 Computational biologySynthetic biologyBiologyPermeability (electromagnetism)Biochemical engineering
• Terminally exhausted CD8+ T cells in solid tumors: biology, biomarker potential and translational tools for precision oncology
  Terminally exhausted CD8 + T cells (Ttex) are emerging as clinically relevant immune subsets across solid tumors, marked by sustained inhibitory receptor expression, loss of TCF1, and limited proliferative capacity. Once considered functionally inert, Ttex are…
  openalex Xuejun Guo, Shuhan Ma, Jingwen Wang, Yilin Fu 等 2026-01-12 置信度 0.72 MedicineMultiplexBiomarkerImmunotherapyCancer research
• Characterization and orthogonality assessment of two quorum sensing systems for synthetic biology applications
  Quorum sensing systems have a broad range of applications within the field of synthetic biology. However, a bottleneck is the optimization and tuning of these systems due to the lack of standardization and complete characterization. In this research, two quoru…
  openalex Jasmine De Baets, Brecht De Paepe, Marjan De Mey 2025-08-19 置信度 0.72 OrthogonalityQuorum sensingCharacterization (materials science)Computational biologyBiology
• Using Synthetic Health Care Data to Leverage Large Language Models for Named Entity Recognition: Development and Validation Study
  BACKGROUND: Named entity recognition (NER) plays a vital role in extracting critical medical entities from health care records, facilitating applications such as clinical decision support and data mining. Developing robust NER models for low-resource languages…
  openalex Hendrik Šuvalov, Mihkel Lepson, Veronika Kukk, Maria Malk 等 2025-01-31 置信度 0.72 PreprintLeverage (statistics)Health careData scienceComputer science
• Iterative SCRaMbLE for engineering synthetic genome modules and chromosomes
  Saccharomyces cerevisiae is closing-in on the first synthetic eukaryotic genome with genome-wide redesigns, including LoxPsym site insertions that enable inducible genomic rearrangements in vivo via Cre recombinase through SCRaMbLE (Synthetic Chromosome Recomb…
  openalex Xinyu Lu, Klaudia Ciurkot, Glen-Oliver F. Gowers, W. M. Shaw 等 2025-08-07 置信度 0.72 GenomeSynthetic biologyComputational biologyBiologyMetabolic engineering
• Current progress in synthetic and medicinal chemistry of pyrazole hybrids as potent anticancer agents with SAR studies
  Abstract Background One of the most serious and potentially hazardous diseases that trouble the globe today is cancer. Among various cancer treatment options, chemotherapy is currently one of the most efficient ways to remove cancer. Heterocycles play a pivota…
  openalex Bhupender Nehra, Manoj Kumar, Viney Chawla, Pooja A. Chawla 2025-06-16 置信度 0.72 PyrazoleChemistryBiochemical engineeringCombinatorial chemistryComputational biology
• Characterising a New Cannabis Trend: Extensive Analysis of Semi‐Synthetic Cannabinoid‐Containing Seizures From Germany
  ABSTRACT In May 2022, semi‐synthetic cannabinoids (SSC) appeared on the European drug market, claiming to offer a legal alternative with cannabimimetic effects. Since then, the use of hexahydrocannabinol (HHC) has quickly become very popular and derivatives, a…
  openalex Marica Hundertmark, Laura Besch, J. Röhrich, Tanja Germerott 等 2025-03-19 置信度 0.72 Synthetic cannabinoidsCannabisCannabinoidChemistryMedicine
• Advances in the cell biology of the trafficking and processing of amyloid precursor protein: impact of familial Alzheimer's disease mutations
  The production of neurotoxic amyloid-β peptides (Aβ) is central to the initiation and progression of Alzheimer's disease (AD) and involves sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. APP and the secretases are transmembra…
  openalex Jingqi Wang, Lou Fourrière, Paul A. Gleeson 2024-09-20 置信度 0.72 Amyloid precursor proteinAmyloid precursor protein secretaseAlpha secretaseIntracellularP3 peptide
• Arboviral Diseases in a Changing World: Evolutionary Dynamics, Host–Vector Interactions, and Novel Control Strategies
  Introduction: Arboviral diseases, transmitted by hematophagous arthropods such as mosquitoes and ticks, represent an escalating global public health challenge. The resurgence and geographic spread of arboviruses particularly dengue virus, Zika virus, chikungun…
  openalex Ebrahim Abbasi 2025-09-16 置信度 0.72 Multidisciplinary approachWarrantControl (management)Vector (molecular biology)Risk analysis (engineering)
• Six Shades of Vascular Smooth Muscle Cells Illuminated by KLF4 (Krüppel-Like Factor 4)
  Multiple layers of vascular smooth muscle cells (vSMCs) are present in blood vessels forming the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to contract and relax, thus modulating blood flow. They also play a crucial role in th…
  openalex Carmen Yap, Arnout Mieremet, Carlie J.M. de Vries, Dimitra Micha 等 2021-09-02 置信度 0.72 KrüppelKLF4AnatomyFactor (programming language)Chemistry
• Machine Learning-assisted Quorum Sensing Monitoring and Control Systems for Precision Gene Regulation: Revolutionizing Synthetic Biology and Autonomous Therapeutic Applications
  openalex Đặng Anh Tuấn, Pham Vu Nhat Uyen 2025-12-19 置信度 0.72 Quorum sensingComputer scienceSynthetic biologyReduction (mathematics)Pseudomonas aeruginosa
• Engineering microbial pathways for production of bio-based chemicals from lignocellulosic sugars: current status and perspectives
  tons. It is an inedible renewable carbonaceous resource that is very rich in pentose and hexose sugars. The ability of microorganisms to use lignocellulosic sugars can be exploited for the production of biofuels and chemicals, and their concurrent biotechnolog…
  openalex Jean François, Ceren Alkım, Nicolas Morin 2020-07-08 置信度 0.72 Metabolic engineeringLignocellulosic biomassBiofuelBiochemical engineeringPentose
• Synthetic heparan sulfate mimics based on chitosan derivatives show broad-spectrum antiviral activity
  Enveloped viruses enter cells by binding to receptors present on host cell membranes, which trigger internalization and membrane fusion. For many viruses, this either directly or indirectly involves interaction with membrane-anchored carbohydrates, such as hep…
  openalex Julia Revuelta, Luciana Rusu, Clara Francés‐Gómez, Elena Trapero 等 2025-03-04 置信度 0.72 Heparan sulfateBroad spectrumSulfateChitosanChemistry
• Recent Advances in the Therapeutic Potential of Cannabinoids Against Gliomas: A Systematic Review (2022–2025)
  ABSTRACT Glioma is the most common and lethal primary brain tumor in adults, with glioblastoma (GBM) representing the most aggressive subtype, characterized by diffuse infiltration, resistance to therapy, and a poor prognosis. Despite standard treatments, surv…
  openalex Farideh Javid, Andrej Belančić, Man Ki Kwok, Yun Wah Lam 2025-08-01 置信度 0.72 MedicineSystematic reviewMEDLINEIntensive care medicineChemistry
• Campesterol Semi‐Synthetic Derivatives as Potential Antibacterial: in vitro and in silico Evaluation
  Abstract In this study, twelve campesterol derivatives (2–13) were prepared by esterification reaction at the hydroxy group in C‐3 and catalytic hydrogenation at the carbon‐carbon double bond in C‐5(6). All obtained compounds were characterized by IR, 1H‐NMR, …
  openalex Francisco Erivaldo Freitas da Silva, Francisco das Chagas Lima Pinto, Otília Deusdênia Loiola Pessoa, Aluísio Marques da Fonseca 等 2023-06-19 置信度 0.72 ChemistryAntibacterial activityEscherichia coliBroth microdilutionStereochemistry
• Performance of abiotic stress-inducible synthetic promoters in genetically engineered hybrid poplar (Populus tremula × Populus alba)
  Abiotic stresses can cause significant damage to plants. For sustainable bioenergy crop production, it is critical to generate resistant crops to such stress. Engineering promoters to control the precise expression of stress resistance genes is a very effectiv…
  openalex Yongil Yang, Yuanhua Shao, Timothy A. Chaffin, Jun Hyung Lee 等 2022-10-18 置信度 0.72 BiologyAbiotic stressAbiotic componentBotanyGenetically modified crops
• Habitat suitability modelling and niche theory
  1 The concept of the ecological niche relates a set of environmental variables to the fitness of species, while habitat suitability models (HSMs) relate environmental variables to the likelihood of occurrence of the species. In spite of this relationship, the …
  openalex Alexandre H. Hirzel, Gwenaëlle Le Lay 2008-07-21 置信度 0.72 NicheEcological nicheEnvironmental niche modellingNiche segregationEcology
• Enzymatic Halogenation: A Timely Strategy for Regioselective C−H Activation
  Halogenating enzymes are increasingly attracting attention for biocatalytic C-H functionalization. Despite its importance for synthetic chemistry, selective introduction of halogens using conventional approaches often remains challenging, whereas biocatalysis …
  openalex Christian Schnepel, Norbert Sewald 2017-05-02 置信度 0.72 HalogenationRegioselectivityChemistryCombinatorial chemistryBiocatalysis
• Beyond the Information Given
  openalex Jerome S. Bruner 2025-05-20 置信度 0.72 Computer science
• Biology Roadmap for Research Infrastructures 2025–2028 by the Swiss Biology Community
  This community roadmap expresses a vision for the future development of biological research in Switzerland and the infrastructure needs identified to realise this vision. It describes four dedicated network infrastructures with a common challenge of comprehens…
  openalex Dani Brunner, Christine Durinx, Msf Erb, Moritz Fischer 等 2021-01-01 置信度 0.72 BiologyData scienceComputational biologyComputer science
• Rational design and characterization of enhanced alcohol-inducible synthetic promoters in Pichia pastoris
  ABSTRACT The C1 and C2 alcohols hold great promise as substrates for biomanufacturing due to their low cost and rich resources. Pichia pastoris is considered a preferred host for methanol and ethanol bioconversion due to its natural utilization of methanol and…
  openalex Qi Liu, Yunhao Li, Liu-fei Tao, Jia-yi Yang 等 2024-12-19 置信度 0.72 Pichia pastorisPromoterRational designSynthetic biologyAlcohol
• Natural and synthetic 5‐(3′‐indolyl)oxazoles: Biological activity, chemical synthesis and advanced molecules
  5-(3'-Indolyl)oxazole moiety is a privileged heterocyclic scaffold, embedded in many biologically interesting natural products and potential therapeutic agents. Compounds containing this scaffold, whether from natural sources or synthesized, have demonstrated …
  openalex Jing‐Rui Liu, Enyu Jiang, Otgonpurev Sukhbaatar, Weihua Zhang 等 2024-08-16 置信度 0.72 OxazoleMoietyChemistryCombinatorial chemistryScaffold
• Mechanism of hormone action The effect of synthetic corticosteroids on liver RNA, and hepatic ribonuclease and ribonuclease inhibitor activities in rats
  openalex N.K. Sarkar 1969-07-01 置信度 0.72 RNase PRNARibonucleaseChemistryMechanism of action
• Bioremediation of Synthetic Dyes by White-Rot Fungi: Enzymatic Mechanisms, Biosorption, and Environmental Applications
  The widespread utilization of synthetic dyes within the textile industry, driven by their chemical recalcitrance and diverse chromatic spectra, constitutes a significant global environmental challenge. Improper discharge of these highly stable effluents into n…
  openalex Anna Carolina Bruno Ferreira, Ygor Velloso Tavares, Nina Rezende Fontana, Thiago Machado Pasin 等 2026-03-26 置信度 0.72 BioremediationLaccaseBioprocessBiochemical engineeringEnvironmental science
• Proteinases in the joint: clinical relevance of proteinases in joint destruction
  Proteinases are involved in essential steps in cartilage and bone homeostasis. Consequently, efforts have been made to establish their potential role in the pathology of rheumatic conditions such as rheumatoid arthritis, osteoarthritis and spondyloarthritis. M…
  openalex Yvonne Rengel, Caroline Ospelt, Steffen Gay 2007-01-01 置信度 0.72 MedicineMatrix metalloproteinaseRheumatoid arthritisRheumatologyOsteoarthritis
• Tumor microenvironment signaling and therapeutics in cancer progression
  Tumor development and metastasis are facilitated by the complex interactions between cancer cells and their microenvironment, which comprises stromal cells and extracellular matrix (ECM) components, among other factors. Stromal cells can adopt new phenotypes t…
  openalex Anshika Goenka, Fatima Khan, Bhupender Verma, Priyanka Sinha 等 2023-04-02 置信度 0.72 Tumor microenvironmentCell biologyCancer researchBiologyCXCL14
• Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation
  For the past 40 years or so, oxidative stress has been increasingly recognized as a contributing factor in aging and in various forms of pathophysiology generally associated with aging. Our view of oxidative stress has been largely "superoxide-centric", as we …
  openalex Brooks M. Hybertson, Bifeng Gao, Swapan K. Bose, Joe M. McCord 2011-08-01 置信度 0.72 Oxidative stressSuperoxide dismutaseBiologyTranscription factorImmune system
• Next-Generation Sequencing — An Overview of the History, Tools, and “Omic” Applications
  Next-generation sequencing (NGS) technologies using DNA, RNA, or methylation sequencing have impacted enormously on the life sciences. NGS is the choice for large-scale genomic and transcriptomic sequencing because of the high-throughput production and outputs…
  openalex Jerzy K. Kulski 2016-01-14 置信度 0.72 DNA sequencingGenomicsBiologyComputational biologySanger sequencing
• Microarray analysis of microRNA expression in the developing mammalian brain
  BACKGROUND: MicroRNAs are a large new class of tiny regulatory RNAs found in nematodes, plants, insects and mammals. MicroRNAs are thought to act as post-transcriptional modulators of gene expression. In invertebrates microRNAs have been implicated as regulato…
  openalex Eric A. Miska, Ezequiel Alvarez-Saavedra, Matthew Townsend, Akira Yoshii 等 2004-08-31 置信度 0.72 BiologyHuman geneticsmicroRNAComputational biologyGenome Biology
• The Multifaceted Role of p53 in Cancer Molecular Biology: Insights for Precision Diagnosis and Therapeutic Breakthroughs
  The protein p53, often referred to as the "guardian of the genome," is essential for preserving cellular balance and preventing cancerous transformations. As one of the most commonly altered genes in human cancers, its impaired function is associated with tumo…
  openalex Bolong Xu, Ayitila Maimaitijiang, Dawuti Nuerbiyamu, Zhengding Su 等 2025-07-27 置信度 0.72 BiologyContext (archaeology)Immune checkpointReprogrammingCancer
• Synthetic Biopolymers
  Synthetic biopolymers are those biobased polymers that can be possibly derived from renewable natural sources and are sustainable as they are biodegradable. The research in the field of synthetic biopolymers is fast progressing, with work on the mode of fabric…
  openalex Reeba Mary Cherian, Rini Thresia Varghese, Jithin Joy, Cintil Jose 等 2024-01-20 置信度 0.72 BiopolymerSynthetic polymerNatural polymersPolymerMaterials science
• Designing a broad-spectrum integrative approach for cancer prevention and treatment
  Targeted therapies and the consequent adoption of "personalized" oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most pat…
  openalex Keith I. Block, Charlotte Gyllenhaal, Leroy Lowe, Amedeo Amedei 等 2015-11-18 置信度 0.72 Broad spectrumTumor microenvironmentCancerMechanism (biology)Personalized medicine
• Recent developments in the synthesis and synthetic applications of borane–amines
  generated borane, salt metathesis, and Lewis base exchange, are discussed in detail with emphasis on recent protocols and borane-ammonia preparation techniques. Applications of borane-amines in organic synthesis where they serve as selective and more easily ha…
  openalex Henry J. Hamann, P. Veeraraghavan Ramachandran 2025-12-11 置信度 0.72 BoraneOrganic synthesisHydroborationDiboraneChemistry
• Systematic modulation of bacterial resource allocation by perturbing RNA polymerase availability via synthetic transcriptional switches
  Gene regulation and its interplay with physiological behaviors are the central topics of modern biology. Classical studies on gene regulation focus intensively on specific regulatory mechanisms of transcription. Nevertheless, the genome-wide impact of RNA poly…
  openalex Manlu Zhu, Xiongfeng Dai 2025-08-06 置信度 0.72 BiologySigma factorRegulation of gene expressionGene expressionRNA polymerase
• Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems
  Novel tissue regeneration strategies are constantly being developed worldwide. Research on bone regeneration is noteworthy, as many promising new approaches have been documented with novel strategies currently under investigation. Innovative biomaterials that …
  openalex Aleksandra Szwed, Przemysław Płociński, Barbara Kupikowska-Stobba, Mateusz M. Urbaniak 等 2023-08-16 置信度 0.72 ScaffoldRegeneration (biology)BiomoleculeBiocompatibilityNanotechnology
• Harnessing synthetic biology to empower a circular plastics economy
  Biotechnology offers unique opportunities for mitigating and upcycling plastic waste with low-intensity bioprocesses. Synthetic biology can further enhance bioprocesses for sustainably dealing with plastic waste and supporting a circular plastics economy. We p…
  openalex Aaron Yip, Michael Weldon, Ida Putu Wiweka Dharmasiddhi, Brian Zubrzycki 等 2025-01-01 置信度 0.72 Circular economySynthetic biologyPlastic wasteBiochemical engineeringSustainability
• Targeting telomerase for its advent in cancer therapeutics
  Telomerase has emerged as an important primary target in anticancer therapy. It is a distinctive reverse transcriptase enzyme, which extends the length of telomere at the 3' chromosomal end, and uses telomerase reverse transcriptase (TERT) and telomerase RNA t…
  openalex Shalini Bajaj, Maushmi S. Kumar, Godefridus J. Peters, YC Mayur 2020-05-11 置信度 0.72 TelomeraseTelomerase reverse transcriptaseTelomereCancerBiology
• Enhancing Wearable Fall Detection System via Synthetic Data
  Deep learning models rely heavily on extensive training data, but obtaining sufficient real-world data remains a major challenge in clinical fields. To address this, we explore methods for generating realistic synthetic multivariate fall data to supplement lim…
  openalex Minakshi Debnath, Sana Alamgeer, Md Shahriar Kabir, Anne H. H. Ngu 2025-07-26 置信度 0.72 Computer scienceSynthetic dataDiscriminative modelArtificial intelligenceMachine learning
• Injectable protease-operated depots of glucagon-like peptide-1 provide extended and tunable glucose control
  Peptide drugs are an exciting class of pharmaceuticals increasingly used for the treatment of a variety of diseases; however, their main drawback is a short half-life, which dictates multiple and frequent injections and an undesirable "peak-and-valley" pharmac…
  openalex Miriam Amiram, Kelli M. Luginbuhl, Xinghai Li, Mark N. Feinglos 等 2013-01-28 置信度 0.72 PeptideProteaseDrug deliveryBiochemistryChemistry
• Computational design of dynamic biosensors for emerging synthetic opioids
  Nitazenes are an emergent class of synthetic opioids that often rival or exceed fentanyl in their potency. These compounds have been detected internationally in illicit drugs and are the cause of increasing numbers of hospitalizations and overdoses. New analog…
  openalex Alison C. Leonard, Chase Lenert-Mondou, Rachel Chayer, Samuel D. Swift 等 2026-01-07 置信度 0.72 Computational biologyComputer scienceNanotechnologySynthetic biologyDrug discovery
• Nanotechnology in agri-food production: an overview
  Nanotechnology is one of the most important tools in modern agriculture, and agri-food nanotechnology is anticipated to become a driving economic force in the near future. Agri-food themes focus on sustainability and protection of agriculturally produced foods…
  openalex Bhupinder Singh Sekhon 2014-05-01 置信度 0.72 AgrochemicalApplications of nanotechnologyAgricultureFood processingBiotechnology
• What is Trust? A Multidisciplinary Review, Critique, and Synthesis
  Abstract Despite decades of interdisciplinary research on trust, the literature remains fragmented and balkanized with little consensus regarding its origins. This review documents how this came to be and attempts to offer a solution. Specifically, it evaluate…
  openalex Blaine G. Robbins 2016-10-01 置信度 0.72 ConceptualizationMultidisciplinary approachSociologyEpistemologyTrustworthiness
• Function, structure and therapeutic potential of complement C5a receptors
  Complement fragment (C)5a is a 74 residue pro-inflammatory polypeptide produced during activation of the complement cascade of serum proteins in response to foreign surfaces such as microorganisms and tissue damaged by physical or chemical injury. C5a binds to…
  openalex Peter N. Monk, A‐M Scola, Praveen K. Madala, David P. Fairlie 2007-07-02 置信度 0.72 C5a receptorReceptorComplement systemBiologyCell biology
• Generating synthetic genotypes using diffusion models
  SUMMARY: In this paper, we introduce the first diffusion model designed to generate complete synthetic human genotypes, which, by standard protocols, one can straightforwardly expand into full-length, DNA-level genomes. The synthetic genotypes mimic real human…
  openalex Philip Kenneweg, Raghuram Dandinasivara, Xiao Luo, Barbara Hammer 等 2025-04-26 置信度 0.72 ReplicateGenotypeComputer scienceCode (set theory)Genome
• Molecular biology of scrapie-like agents
  A detailed account is given of the nature of the causal agent of scrapie and other transmissible spongiform encephalopathies, with reference to proteinase-resistant protein and its gene, subviral particles and the prion hypothesis.
  openalex Alan Bennett, Christopher R. Birkett, Christopher J. Bostock 1992-06-01 置信度 0.72 ScrapieVirologyBiologyPrion proteinBovine spongiform encephalopathy
• Environmental control programs the emergence of distinct functional ensembles from unconstrained chemical reactions
  Many approaches to the origin of life focus on how the molecules found in biology might be made in the absence of biological processes, from the simplest plausible starting materials. Another approach could be to view the emergence of the chemistry of biology …
  openalex Andrew J. Surman, Marc Rodriguez‐Garcia, Yousef M. Abul‐Haija, Geoffrey J. T. Cooper 等 2019-03-06 置信度 0.72 Function (biology)Biochemical engineeringAbiogenesisComputational biologyComputer science
• Deep-learning-based design of synthetic orthologs of SH3 signaling domains
  openalex Xinran Lian, Niksa Praljak, Subu Subramanian, Sarah Wasinger 等 2024-08-01 置信度 0.72 SH3 domainComputational biologySynthetic biologyGenerative modelBiology
• SYNBIP 2.0: epitopes mapping, sequence expansion and scaffolds discovery for synthetic binding protein innovation
  Synthetic binding proteins (SBPs) represent a pivotal class of artificially engineered proteins, meticulously crafted to exhibit targeted binding properties and specific functions. Here, the SYNBIP database, a comprehensive resource for SBPs, has been signific…
  openalex Yanlin Li, Fengcheng Li, Zixin Duan, Ruihan Liu 等 2024-10-16 置信度 0.72 Protein Data BankEpitopeComputational biologyBiologySequence (biology)
• Antimicrobial Potential of Polyphenols: Mechanisms of Action and Microbial Responses—A Narrative Review
  Polyphenols (PPs) are recognized as bioactive compounds and antimicrobial agents, playing a critical role in enhancing food safety, preservation, and extending shelf life. The antimicrobial effectiveness of PPs has different molecular and biological reasons, p…
  openalex Luca Rossi, Gabriele Rocchetti, Luigi Lucini, Annalisa Rebecchi 2025-02-10 置信度 0.72 AntimicrobialPolyphenolChemistryBiologyBiochemistry
• Relationships in the age of AI: A review on the opportunities and risks of synthetic relationships to reduce loneliness
  Loneliness is a pressing global health issue, yet traditional interventions often fall short due to scalability limitations and the individualized experiences of loneliness. The rise of generative artificial intelligence (AI) has enabled synthetic relationship…
  openalex Alfio Ventura, Christopher Starke, Francesca Righetti, Nils Köbis 2026-06-25 置信度 0.72 LonelinessPsychologySocial psychology
• Articular cartilage repair and transplantation
  View article in HTML via Journals@Ovid Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author…
  openalex Joseph A. Buckwalter, Henry J. Mankin 1998-08-01 置信度 0.72 TransplantationCartilageContent (measure theory)Articular cartilageMedicine
• Light‐Triggered Protease‐Mediated Release of Actin‐Bound Cargo from Synthetic Cells
  Synthetic cells offer a versatile platform for addressing biomedical and environmental challenges, due to their modular design and capability to mimic cellular processes such as biosensing, intercellular communication, and metabolism. Constructing synthetic ce…
  openalex Mousumi Akter, Hossein Moghimianavval, Gary D. Luker, Allen P. Liu 2025-01-18 置信度 0.72 SecretionActinSynthetic biologyProteaseDrug delivery
• Recent progress in the synthesis of advanced biofuel and bioproducts
  openalex Brian F. Pfleger, Ralf Takors 2023-02-26 置信度 0.72 BioproductsBiofuelFossil fuelRenewable energyBiochemical engineering
• Roles of microbial interactions in determining the establishment and function of synthetic consortium inoculants for soil applications
  Synthetic microbial consortium inoculants are emerging nature-based solutions for promoting sustainable agriculture and mitigating environmental challenges. However, despite promising results in simpler lab-scale trials, many inoculants fail to establish or pe…
  openalex Yun Xu, Shilva Shrestha, Qing Sun, Ying Wang 2025-01-02 置信度 0.72 Microbial inoculantEcosystemEcosystem servicesPsychological resilienceBiotechnology
• Harnessing plant agriculture to mitigate climate change: A framework to evaluate synthetic biology (and other) interventions
  Plant agriculture contributes substantially to global greenhouse gas emissions, yet it also offers powerful opportunities for climate change mitigation. Here, we focus on how to identify and prioritize synthetic biology strategies to reduce emissions and seque…
  openalex Claudia E. Vickers, Philipp Zerbe 2025-09-19 置信度 0.72 Greenhouse gasSynthetic biologyAgricultureSoftware deploymentBiomass (ecology)
• A Review on the Synthetic Methods for the BODIPY Core
  Boron-dipyrromethene (BODIPY) has attracted extensive research attention in recent years due to its excellent photophysical properties, good chemical stability, and structural tunability, demonstrating broad application in fields such as fluorescence imaging, …
  openalex Ruihan Yang, Hao Guan, Jiayan Jin, Tianran Zheng 等 2025-10-17 置信度 0.72 BODIPYNanotechnologyCore (optical fiber)Computer scienceChemistry
• Review of generative AI for synthetic data generation: a healthcare perspective
  Abstract Generative AI has emerged as a transformative technology in healthcare, enabling the generation of high-fidelity synthetic data for applications such as medical imaging, electronic health records, biomedical signal processing, and drug discovery. The …
  openalex Hafiz Muhammad Waseem, Saif ul Islam, Nicholas Matragkas, Gregory Epiphaniou 等 2025-12-10 置信度 0.72 Generative grammarComputer scienceTransformative learningHealth careArtificial intelligence
• Protein–Polymer Conjugates: Advancing Enzyme Catalysis in Synthetic Chemistry
  Abstract Enzyme catalysis is prominent in chemical synthesis due to its specificity, selectivity, and efficiency. However, enzymes often face challenges, such as inactivation and inhibition in practical applications, and they are also limited by narrow reactio…
  openalex Jingping Ouyang, Jian Li, Changzhu Wu 2024-10-01 置信度 0.72 ChemistryEnzyme catalysisConjugateProtein chemistryBiocatalysis
• Novel synthetic inducible promoters controlling gene expression during water‐deficit stress with green tissue specificity in transgenic poplar
  Synthetic promoters may be designed using short cis-regulatory elements (CREs) and core promoter sequences for specific purposes. We identified novel conserved DNA motifs from the promoter sequences of leaf palisade and vascular cell type-specific expressed ge…
  openalex Yongil Yang, Timothy A. Chaffin, Yuanhua Shao, Vimal Kumar Balasubramanian 等 2024-01-17 置信度 0.72 BiologyTransgenePromoterGeneGene expression
• Crops that feed the world 6. Past successes and future challenges to the role played by maize in global food security
  Maize is one of the most important food crops in the world and, together with rice and wheat, provides at least 30% of the food calories to more than 4.5 billion people in 94 developing countries. In parts of Africa and Mesoamerica, maize alone contributes ove…
  openalex Bekele Shiferaw, B. M. Prasanna, Jon Hellin, Marianne Bänziger 2011-08-23 置信度 0.72 Food securityAgricultureContext (archaeology)LivelihoodGreen Revolution
• Proteogenomic insights into the biology and treatment of pan-melanoma
  Melanoma is one of the most prevalent skin cancers, with high metastatic rates and poor prognosis. Understanding its molecular pathogenesis is crucial for improving its diagnosis and treatment. Integrated analysis of multi-omics data from 207 treatment-naïve m…
  openalex Xiang Hang, Rongkui Luo, Yunzhi Wang, Bing Yang 等 2024-07-22 置信度 0.72 MelanomaImmunotherapyCancer researchMetastatic melanomaImmune system
• Reasons for multiple biologic and targeted synthetic DMARD switching and characteristics of treatment refractory rheumatoid arthritis
  openalex Gregory C McDermott, Michael DiIorio, Yumeko Kawano, Mary Jeffway 等 2024-03-01 置信度 0.72 MedicineRheumatoid arthritisRefractory (planetary science)Biologic AgentsAntirheumatic Agents
• The biology and toxinology of blunt-nosed vipers
  Blunt-nosed vipers (genus Macrovipera) are among the venomous snakes of highest medical relevance in the Palearctic region. Extensive research has been conducted on their venoms, covering toxin composition, biochemistry, function, pathology and biodiscovery. H…
  openalex Ignazio Avella, Maik Damm, Matteo Riccardo Di Nicola, Josephine Dresler 等 2025-06-03 置信度 0.72 BluntBiologyZoologyMedicineSurgery
• Moringa oleifera is a Prominent Source of Nutrients with Potential Health Benefits
  Nowadays, the socioeconomic status has been changed a lot, so people are now more concerned about their life style and health. They have knowledge about the detrimental effects of synthetic products. That is why they are interested in natural products. Utiliza…
  openalex Zahidul Islam, S. M. Rashadul Islam, Faruk Hossen, Kazi Mahtab-Ul-Islam 等 2021-08-10 置信度 0.72 MoringaIngredientHealth benefitsMicronutrientTraditional medicine
• Telomere Maintenance and DNA Repair: A Bidirectional Relationship in Cancer Biology and Therapy
  Telomeres are repetitive DNA sequences at the ends of chromosomes that protect against genomic instability and prevent unwanted DNA damage responses. In most somatic cells, telomeres progressively shorten with each division, limiting cellular lifespan. However…
  openalex Nina Rembiałkowska, Mikołaj Sędzik, Monika Kisielewska, Wiktoria Łuniewska 等 2025-07-09 置信度 0.72 TelomereTelomeraseGenome instabilityDNA repairBiology
• Genetically engineered bacterium: Principles, practices, and prospects
  Advances in synthetic biology and the clinical application of bacteriotherapy enable the use of genetically engineered bacteria (GEB) to combat various diseases. GEB act as a small 'machine factory' in the intestine or other tissues to continuously produce het…
  openalex Yiting Liu, Jing Feng, Hangcheng Pan, Xiuwei Zhang 等 2022-10-13 置信度 0.72 DiseaseGenetically engineeredBiotechnologySynthetic biologyAdjuvant
• Engineering synthetic signaling receptors to enable erythropoietin-free erythropoiesis
  Blood transfusion plays a vital role in modern medicine, but frequent shortages occur. Ex vivo manufacturing of red blood cells (RBCs) from universal donor cells offers a potential solution, yet the high cost of recombinant cytokines remains a barrier. Erythro…
  openalex Aadit P. Shah, Kiran R. Majeti, Freja K. Ekman, Sridhar Selvaraj 等 2025-01-29 置信度 0.72 ErythropoiesisErythropoietinReceptorSignal transductionCell biology
• A framework for complex signal processing via synthetic biological operational amplifiers
  Engineering genetic circuits to process complex biological signals remains a significant challenge due to non-orthogonal signal responses that limit precise control. In this study, we introduce a framework that integrates orthogonal operational amplifiers (OAs…
  openalex Wenjun Cao, Lili Liu, Qing Sun, Yang Shan 等 2025-07-31 置信度 0.72 Computer scienceSignal processingSIGNAL (programming language)Digital signal processingComputer hardware
• Neuroprotective effect of neuron‐specific deletion of the C16 ceramide synthetic enzymes in an animal model of multiple sclerosis
  Ceramide C16 is a sphingolipid detected at high levels in several neurodegenerative disorders, including multiple sclerosis (MS). It can be generated de novo or from the hydrolysis of other sphingolipids, such as sphingomyelin or through the recycling of sphin…
  openalex Mario Amatruda, Damien Maréchal, Mar Gacias, Maureen Wentling 等 2024-11-03 置信度 0.72 CeramideSphingolipidCeramide synthaseMultiple sclerosisBiology
• The Impact of Nanobodies on G Protein–Coupled Receptor Structural Biology and Their Potential as Therapeutic Agents
  openalex David Salom, Arum Wu, Chang C. Liu, Krzysztof Palczewski 2024-08-06 置信度 0.72 Computational biologyG protein-coupled receptorBiologyReceptorBiochemistry
• Preserving the Immune‐Privileged Niche of the Nucleus Pulposus: Safeguarding Intervertebral Discs from Degeneration after Discectomy with Synthetic Mucin Hydrogel Injection
  Intervertebral disc (IVD) herniation is a prevalent spinal disorder, often necessitating surgical intervention such as microdiscectomy for symptomatic relief and nerve decompression. IVDs comprise a gel-like nucleus pulposus (NP) encased by an annulus fibrosus…
  openalex Huan Wang, Song Chen, Zhao Liu, Qingchen Meng 等 2024-08-29 置信度 0.72 Degeneration (medical)NucleusDiscectomyIntervertebral discImmune system
• The Overlapping Biology of Sepsis and Cancer and Therapeutic Implications
  Sepsis and cancer, though distinct in their clinical manifestations, share profound pathophysiological overlaps that underscore their interconnectedness in disease progression and outcomes. Here we discuss the intricate biological mechanisms linking these two …
  openalex Amit Kumar Tripathi, Yogesh Srivastava 2025-05-23 置信度 0.72 Immune systemCancerImmunologyTumor microenvironmentSepsis
• A roadmap toward the synthesis of life
  The synthesis of life from non-living matter has captivated and divided scientists for centuries. This bold goal aims at unraveling the fundamental principles of life and leveraging its unique features, such as its resilience, sustainability, and ability to ev…
  openalex Christine M. E. Kriebisch, Olga Bantysh, Lorena Baranda Pellejero, Andrea Belluati 等 2025-02-06 置信度 0.72 Engineering ethicsPolitical scienceEngineering
• From “synthetic” to defined microbial communities for clearer terminology
  Consortia of microbial isolates, also known as synthetic communities (SynComs), are increasingly used to study and harness microbe-microbe and microbe-host interactions. Since “synthetic” potentially evokes negative connotations, we propose adopting the term “…
  openalex Hanna Koch, Thomas Clavel, Cintia Mayr, Benjamin L. Coltman 等 2026-06-08 置信度 0.72 TerminologyComputational biologyBiologyEvolutionary biologyData science
• Advances in Sweet Corn (Zea mays L. saccharata) Research from 2010 to 2025: Genetics, Agronomy, and Sustainable Production
  Sweet corn (Zea mays L. saccharata) has emerged as a valuable crop not only for its economic potential but also for its role in sustainable food systems due to its high consumer demand and adaptability. As global agricultural systems face increasing pressure f…
  openalex Hajer Mohamed Ibrahim Sidahmed, Attila Vad, János Nagy 2025-05-21 置信度 0.72 Zea maysAgronomyBiology
• Advances in Synthetic Immunology for Targeted Treatment of Systemic Autoimmune Diseases: Opportunities, Challenges, and Future Directions
  Systemic autoimmune diseases (SAIDs) affect millions worldwide, presenting significant clinical challenges due to their complex pathogenesis and limited treatment options. Traditional immunosuppressive therapies, while effective, often lack precision, leading …
  openalex Galih Januar Adytia, Henry Sutanto, Laras Pratiwi, Deasy Fetarayani 2025-01-25 置信度 0.72 ImmunologyMedicine
• The Convergence of Biology and Material Science: Biomolecule-Driven Smart Drug Delivery Systems
  Biomolecule-driven smart materials represent a paradigm shift in pharmacology, transitioning drug delivery from a passive process to an active, programmable, and highly specific intervention. These systems, constructed from or functionalized with biological ma…
  openalex Yaqin Hou, Xiaolei Yu 2025-09-28 置信度 0.72 Computer scienceProcess (computing)Synthetic biologyKey (lock)Nanotechnology
• Beyond pigments and perfumes: engineering in the carotenoid and apocarotenoid spectrum, novel enzymes, and synthetic biology strategies
  Carotenoids and apocarotenoids constitute a structurally and functionally sundry class of isoprenoids whose significance extends from photosynthetic light capture and photoprotection to phytohormone signaling, flavor and aroma formation, and emerging biomedica…
  openalex Baradwaj Ravi Gopal, Zhen Wang 2026-01-15 置信度 0.72 PhotoprotectionSynthetic biologyCarotenoidMetabolic engineeringPhytoene
• Microplastic Accumulation and Degradation in Environment via Biotechnological Approaches
  The extensive use of plastics in daily life has led to the generation of huge amounts of plastic waste, which causes an enormous burden on the environment. More than half of the plastic waste ends up in the landfill, and about one-fifth of waste is managed by …
  openalex Sonal Thakur, Shivangi Mathur, Saumya Patel, Biswaranjan Paital 2022-12-12 置信度 0.72 MicroplasticsIncinerationPlastic wasteEnvironmental scienceWaste management
• Exploring extracellular vesicles in zoonotic helminth biology: implications for diagnosis, therapeutic and delivery
  Extracellular vesicles (EVs) have emerged as key intercellular communication and pathogenesis mediators. Parasitic organisms' helminths, cause widespread infections with significant health impacts worldwide. Recent research has shed light on the role of EVs in…
  openalex Abdul Qadeer, Abdul Wajid, Hafiz Abdul Rafey, Saqib Nawaz 等 2024-08-06 置信度 0.72 Extracellular vesiclesHelminth infectionsHelminthsBiologyHelminthiasis
• Conversion of natural cytokine receptors into orthogonal synthetic biosensors
  Synthetic receptors enable bioengineers to build cell-based therapies that perform therapeutic functions in a targeted or conditional fashion to enhance specificity and efficacy. Although many synthetic receptors exist, it remains challenging to generate new r…
  openalex Hailey I. Edelstein, Amparo Cosio, Max L. Ezekiel, William K. Corcoran 等 2025-08-22 置信度 0.72 EctodomainReceptorChimeric antigen receptorCytokine receptorBiology
• Circadian Clock Deregulation and Metabolic Reprogramming: A System Biology Approach to Tissue-Specific Redox Signaling and Disease Development
  Circadian rhythms govern cellular metabolism, redox balance, and endocrine signaling in numerous tissues. However, chronic disturbance of these biological rhythms, mediated by modern lifestyle factors including shift work, sleep irregularity, and prolonged lig…
  openalex Rossitza Konakchieva, Mitko Mladenov, Marina Konaktchieva, Iliyana Sazdova 等 2025-06-28 置信度 0.72 Circadian rhythmBiologyCircadian clockProteostasisPyroptosis
• Bone Regeneration: A Review of Current Treatment Strategies
  Bone regeneration has emerged as a critical research and clinical advancement field, fueled by the growing demand for effective treatments in orthopedics and oncology. Over the past two decades, significant progress in biomaterials and surgical techniques has …
  openalex Raffaella De Pace, Silvia Molinari, Elisa Mazzoni, Giuseppe Perale 2025-03-08 置信度 0.72 MedicineRegeneration (biology)Clinical PracticeIntensive care medicineMedical physics
• Novel Natural Candidates for Replacing Synthetic Additives in Nutraceutical and Pharmaceutical Areas: Two Senna Species ( S. alata (L.) Roxb. and S. occidentalis (L.) Link)
  ABSTRACT Senna alata (L.) Roxb. and Senna occidentalis (L.) Link (family Fabaceae) are commonly used in different systems of traditional medicine to treat ailments. The present study was designed to determine the phytoconstituents, antioxidant, enzyme inhibiti…
  openalex Sakina Yagi, Mehmet Veysi Çetiz, Gökhan Zengin, Kassim Bakar 等 2024-12-22 置信度 0.72 FlavonoidChemistryABTSGlycosideDPPH
• Synthetic Peptides: Promising Modalities for the Targeting of Disease‐Related Nucleic Acids
  DNA and RNA play pivotal roles in life processes by storing and transferring genetic information, modulating gene expression, and contributing to essential cellular machinery such as ribosomes. Dysregulation and mutations in nucleic acid-related processes are …
  openalex Brecht D. Ellenbroek, Jan Kähler, Sophie R. Evers, Sebastian Pomplun 2024-03-08 置信度 0.72 Nucleic acidRNAComputational biologyBiologyDNA
• Organic fluorescent compounds: A review of synthetic strategies and emerging applications
  Organic fluorescent compounds have become integral tools across a wide range of applications because of unique ability to absorb light at one wavelength and emit it at a longer wavelength. It plays a crucial role due to their tunable emission wavelengths and h…
  openalex Sowmya Maiya, Glanish Jude Martis, Nitinkumar S. Shetty, Santosh L. Gaonkar 2025-11-04 置信度 0.72 FluorescenceNanotechnologyBiochemical engineeringMaterials scienceChemistry
• Raman, polarized Raman and ultraviolet resonance Raman spectroscopy of nucleic acids and their complexes
  Abstract Applications of Raman spectroscopy to investigate the molecular constituents of nucleic acids were initiated in the late 1960s and soon thereafter progressed to studies of synthetic and native nucleic acids and complex biological assemblies containing…
  openalex James M. Benevides, Stacy A. Overman, George J. Thomas 2005-04-01 置信度 0.72 Nucleic acidRaman spectroscopyNucleic acid structureResonance Raman spectroscopyChemistry
• Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles
  The synthesis of anisotropic metallic nanoparticles (NPs) has been a field of intense and challenging research in the past decade. In this communication, we report on the reproducible and highly controllable synthesis of monodisperse branched gold nanoparticle…
  openalex Sara Abalde‐Cela, Patricia Taladriz‐Blanco, Marcelo G. de Oliveira, Chris Abell 2018-01-30 置信度 0.72 MicrofluidicsDispersityNanotechnologyMicroreactorNanoparticle
• FoxA1 Specifies Unique Androgen and Glucocorticoid Receptor Binding Events in Prostate Cancer Cells
  The forkhead protein FoxA1 has functions other than a pioneer factor, in that its depletion brings about a significant redistribution in the androgen receptor (AR) and glucocorticoid receptor (GR) cistromes. In this study, we found a novel function for FoxA1 i…
  openalex Biswajyoti Sahu, Marko Laakso, Päivi Pihlajamaa, Kristian Ovaska 等 2012-12-27 置信度 0.72 FOXA1Androgen receptorLNCaPProstate cancerTranscription factor
• Surfactant-free production of biomimetic giant unilamellar vesicles using PDMS-based microfluidics
  Microfluidic production of giant lipid vesicles presents a paradigm-shift in the development of artificial cells. While production is high-throughput and the lipid vesicles are mono-disperse compared to bulk methods, current technologies rely heavily on the ad…
  openalex Naresh Yandrapalli, Julien Petit, Oliver Bäumchen, Tom Robinson 2021-06-29 置信度 0.72 VesicleMicrofluidicsArtificial cellLipid vesiclePulmonary surfactant
• Natural peptides and their synthetic congeners acting against Acinetobacter baumannii through the membrane and cell wall: latest progress
  Acinetobacter baumannii is one of the deadliest Gram-negative bacteria (GNB), responsible for 2–10% of hospital-acquired infections.
  openalex Gautam Kumar 2024-11-20 置信度 0.72 Acinetobacter baumanniiMicrobiologyChemistryBiologyBacteria
• Application of process analytical technology for real-time monitoring of synthetic co-culture bioprocesses
  Synthetic microbial co-cultures can enhance bioprocess performance by division-of-labor strategies that, through spatial segregation of product-pathway modules, circumvent or mitigate negative impacts of the expression of an entire product pathway in a single …
  openalex Nicole A Dambruin, Jack T. Pronk, Marieke E. Klijn 2025-06-06 置信度 0.72 BioprocessBiochemical engineeringPopulationProcess analytical technologyMonitoring and control
• Unravelling the Significance of Extracellular Vesicle‐Associated DNA in Cancer Biology and Its Potential Clinical Applications
  Extracellular vesicles (EVs) play a key role in cell-to-cell communication and have drawn significant attention due to their potential clinical applications. However, much remains to be understood about the biology of EV-associated DNA (EV-DNA). EV-DNA is acti…
  openalex Jamal Ghanam, Kristína Lichá, Venkatesh Kumar Chetty, Ommolbanin Asad Pour 等 2025-03-01 置信度 0.72 BiologyDNAEpigeneticsExtracellular vesiclesComputational biology
• Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation
  Biomaterial surface chemistry has profound consequences on cellular and host responses, but the underlying molecular mechanisms remain poorly understood. Using self-assembled monolayers as model biomaterial surfaces presenting well defined chemistries, we demo…
  openalex Benjamin G. Keselowsky, David M. Collard, Andrés J. Garcı́a 2005-04-12 置信度 0.72 IntegrinFibronectinChemistryBiomaterialCell adhesion
• The importance of binding kinetics and drug–target residence time in pharmacology
  A dominant assumption in pharmacology throughout the 20th century has been that in vivo target occupancy-and attendant pharmacodynamics-depends on the systemic concentration of drug relative to the equilibrium dissociation constant for the drug-target complex.…
  openalex Kevin E. Knockenhauer, Robert A. Copeland 2023-05-10 置信度 0.72 PharmacodynamicsDrugPharmacokineticsPharmacologyDrug discovery
• Microalgae-Derived Pigments for the Food Industry
  In the food industry, manufacturers and customers have paid more attention to natural pigments instead of the synthetic counterparts for their excellent coloring ability and healthy properties. Microalgae are proven as one of the major photosynthesizers of nat…
  openalex Han Sun, Yuxin Wang, Yongjin He, Bin Liu 等 2023-01-25 置信度 0.72 PhycobiliproteinFood industryNutraceuticalBiochemical engineeringCarotenoid
• Seeing the Spikes: The Future of Targetable Synthetic Voltage Sensors
  Measuring the transduction of electrical signals within neurons is a key capability in neuroscience. Fluorescent voltage sensitive dyes (VSDs) were early tools that complemented classical electrophysiology by enabling the optical recording of membrane potentia…
  openalex Tomas Fiala, David Sulzer, Dalibor Sameš 2025-02-13 置信度 0.72 NeuroscienceSynthetic biologyElectrophysiologyComputer sciencePerspective (graphical)
• Targeting cancer stem cells with CAR-based immunotherapy: biology, evidence, and future directions
  Cancer stem cells (CSCs) are pivotal in tumor initiation, progression, and relapse, underscoring the need for targeted therapies to achieve lasting responses. This review delves into CSC biology, highlighting their tumor-initiating potential demonstrated throu…
  openalex Kaveh Hadiloo, Parsa Mostanadi, Ali Asadzadeh, Siavash Taremi 等 2025-07-28 置信度 0.72 ImmunotherapyCancer stem cellMedicineTumor microenvironmentCancer immunotherapy
• Scientific and technological innovations of wastewater treatment in China
  Abstract The “dual-carbon” strategy promotes the development of the wastewater treatment sector and is an important tool for leading science and technology innovations. Based on the global climate change and the new policies introduced by China, this paper des…
  openalex Hui Huang, Rui Ma, Hongqiang Ren 2024-03-20 置信度 0.72 ChinaWastewaterBusinessEnvironmental planningEnvironmental science
• PIONEER: A periplasmic display platform for synthetic biology-based screening of genetically encoded protein regulators
  Periplasmic display in yeast is a promising but underdeveloped method for screening and studying genetically encoded biomolecules. We present Periplasmic dIsplay Of geNetically Encoded rEgulatoRs (PIONEER), a modular platform that localizes peptides, proteins,…
  openalex Jacob B. Rowe, Kyutae Lee, Daniel G. Isom 2025-11-21 置信度 0.72 Periplasmic spaceChaperone (clinical)Ligand (biochemistry)Directed Molecular EvolutionBiology
• Availability: A Metric for Nucleic Acid Strand Displacement Systems
  DNA strand displacement systems have transformative potential in synthetic biology. While powerful examples have been reported in DNA nanotechnology, such systems are plagued by leakage, which limits network stability, sensitivity, and scalability. An approach…
  openalex Xiaoping Olson, Shohei Kotani, Jennifer E. Padilla, Natalya Hallstrom 等 2016-02-15 置信度 0.72 Leakage (economics)ScalabilitySynthetic biologyNucleic acidBiochemical engineering
• From Delaunay triangulation to topological data analysis: generation of more realistic synthetic power grid networks
  Abstract Assessing novel methods for increasing power system resilience against cyber-physical hazards requires real power grid data or high-quality synthetic data. However, for security reasons, even basic connection information for real power grid data are n…
  openalex Asim Kumer Dey, Stephen J. Young, Yulia R. Gel 2023-05-22 置信度 0.72 Delaunay triangulationComputer scienceBenchmark (surveying)Metric (unit)Data mining
• Synthetic Forms Most Beautiful: Engineering Insights into Self-Organization
  Reflecting on the diversity of the natural world, Darwin famously observed that "from so simple a beginning endless forms most beautiful and most wonderful have been, and are being evolved." However, the examples that we are able to observe in nature are a con…
  openalex Zhejing Xu, Chih‐Chia Chang, Scott M. Coyle 2025-02-12 置信度 0.72 Synthetic biologyTransformative learningLiving systemsDiversity (politics)Biological evolution
• A synthetic genomics-based African swine fever virus engineering platform
  African swine fever (ASF) is a deadly viral disease in domestic pigs that has a large global economic impact for the swine industry. It is present in Africa, Europe, Asia, and in the Caribbean island of Hispaniola. There are no effective treatments or broadly …
  openalex Walter Fuchs, Nacyra Assad-Garcia, Hussein M. Abkallo, Yong Xue 等 2025-03-26 置信度 0.72 African swine fever virusGenomeCRISPRCas9Virus
• Natural products for cancer chemotherapy
  For over 40 years, natural products have served us well in combating cancer. The main sources of these successful compounds are microbes and plants from the terrestrial and marine environments. The microbes serve as a major source of natural products with anti…
  openalex Arnold L. Demain, Preeti Vaishnav 2010-11-18 置信度 0.72 CancerCancer treatmentChemotherapeutic drugsCancer therapyCancer chemotherapy
• Metabolic bottlenecks of Pseudomonas taiwanensis VLB120 during growth on d-xylose via the Weimberg pathway
  crossref Philipp Nerke, Jonas Korb, Frederick Haala, Georg Hubmann 等 2024-06-06T06:33:01Z 置信度 0.70
• Metabolic engineering of artificially modified transcription factor SmMYB36-VP16 for high-level production of tanshinones and phenolic acids
  crossref Entong Jia, He Li, Fang He, Xiaoyu Xu 等 2024-08-22T22:45:35Z 置信度 0.70
• A machine learning framework for extracting information from biological pathway images in the literature
  crossref Mun Su Kwon, Junkyu Lee, Hyun Uk Kim 2024-09-02T20:40:51Z 置信度 0.70
• Review for "Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids"
  crossref 2024-10-04T17:14:55Z 置信度 0.70
• Genetically encoded biosensors for the circular plastics bioeconomy
  crossref Micaela Chacón, Neil Dixon 2024-11-28T17:21:24Z 置信度 0.70
• Review for "Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids"
  crossref 2024-10-04T17:14:55Z 置信度 0.70
• KETCHUP: Parameterizing of large-scale kinetic models using multiple datasets with different reference states
  crossref Mengqi Hu, Patrick F. Suthers, Costas D. Maranas 2024-02-07T09:23:15Z 置信度 0.70
• Review for "Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids"
  crossref 2024-10-04T17:14:55Z 置信度 0.70
• Revealing the dynamics and mechanisms of bacterial interactions in cheese production with metabolic modelling
  crossref Maxime Lecomte, Wenfan Cao, Julie Aubert, David James Sherman 等 2024-03-08T00:12:03Z 置信度 0.70
• Review for "Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids"
  crossref 2024-10-04T17:14:55Z 置信度 0.70
• Review for "Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids"
  crossref 2024-10-04T17:14:55Z 置信度 0.70
• Resource allocation modeling for autonomous prediction of plant cell phenotypes
  crossref Anne Goelzer, Loïc Rajjou, Fabien Chardon, Olivier Loudet 等 2024-03-30T23:44:34Z 置信度 0.70
• Metabolic engineering and production of secondary metabolites
  crossref Khyati Lehari, Devendra Kumar 2024-03-29T07:06:54Z 置信度 0.70
• Metabolic engineering of linseed crop for enhancing production yield
  crossref Madhvi Sharma, Mahesh Kumar Samota 2024-08-30T05:22:32Z 置信度 0.70
• Engineering Escherichia coli for efficient glutathione production
  crossref Hiroki Mori, Misato Matsui, Takahiro Bamba, Yoshimi Hori 等 2024-07-03T07:31:56Z 置信度 0.70
• Metabolic flux analysis and metabolic engineering for polyhydroxybutyrate (PHB) production
  crossref Bhargavi Subramanian, Souvik Basak, Rithanya Thirumurugan, Lilly M. Saleena 2024-04-04T12:01:59Z 置信度 0.70
• Multi-omic characterization of antibody-producing CHO cell lines elucidates metabolic reprogramming and nutrient uptake bottlenecks
  crossref Saratram Gopalakrishnan, William Johnson, Miguel A. Valderrama-Gomez, Elcin Icten 等 2024-07-22T12:54:01Z 置信度 0.70
• Combinatorial metabolic engineering of Bacillus subtilis for de novo production of polymyxin B
  crossref Hui-Zhong Sun, Qing Li, Wei Shang, Bin Qiao 等 2024-04-04T23:11:47Z 置信度 0.70
• Developing a novel heme biosensor to produce high-active hemoproteins in Pichia pastoris through comparative transcriptomics
  crossref Fei Yu, Chenyang Li, Tao Zhang, Jingwen Zhou 等 2024-06-04T06:57:45Z 置信度 0.70
• Sustainable biosynthesis of squalene from waste cooking oil by the yeast Yarrowia lipolytica
  crossref Shuhui Wang, Xu Sun, Yuqing Han, Zhuo Li 等 2024-06-05T13:28:27Z 置信度 0.70
• Metabolic flux optimization of iterative pathways through orthogonal gene expression control: Application to the β-oxidation reversal
  crossref Seung Hwan Lee, Yang Hu, Alexander Chou, Jing Chen 等 2024-02-20T21:26:34Z 置信度 0.70
• Metabolic Engineering in Plants: Advancing Crop Productivity and Sustainability through Precision Pathway Manipulation
  Metabolic engineering in plants has emerged as a powerful approach to address global challenges in agriculture, nutrition, and sustainability. This comprehensive review explores cutting-edge strategies for manipulating primary and secondary metabolic pathways …
  crossref Katie Fan 2024-07-18T04:54:53Z 置信度 0.70
• Advancing Plant Metabolic Engineering: Enhancing Crop Resilience and Productivity for Sustainable Agriculture
  crossref Katie Fan 2024-07-23T16:46:06Z 置信度 0.70
• High-level production of Rhodiola rosea characteristic component rosavin from D-glucose and L-arabinose in engineered Escherichia coli
  crossref Lijun Li, Moshi Liu, Huiping Bi, Tao Liu 2024-02-28T11:43:44Z 置信度 0.70
• Corrigendum to “Self-controlled in silico gene knockdown strategies to enhance the sustainable production of heterologous terpenoid by Saccharomyces cerevisiae” [Metab. Eng. 83 (2024) 172–182]
  crossref Na Zhang, Xiaohan Li, Qiang Zhou, Ying Zhang 等 2024-05-10T08:07:02Z 置信度 0.70
• Model-based optimization of cell-free enzyme cascades exemplified for the production of GDP-fucose
  crossref Nicolas Huber, Edgar Alberto Alcalá-Orozco, Thomas Rexer, Udo Reichl 等 2023-10-30T18:33:35Z 置信度 0.70
• Decision letter for "Metabolic engineering of crocins and picrocrocin apocarotenoids in potato group phureja"
  crossref 2024-08-28T19:51:30Z 置信度 0.70
• Decision letter for "Metabolic engineering of crocins and picrocrocin apocarotenoids in potato group phureja"
  crossref 2024-08-28T19:51:30Z 置信度 0.70
• ¹³ C Metabolic Flux Analysis in Chondrocytes Reveals a Novel Switch in Metabolic Phenotype
  crossref Roberto Tarantino, Halie Mei Jensen, Stephen D. Waldman 2024-02-18T08:44:15Z 置信度 0.70
• Microbial Production of Alternative Proteins for Food Applications: Advances, Industrial Challenges, and Regulatory Status.
  The escalating global population and the environmentally inefficient nature of livestock-based protein production are intensifying demand for sustainable and scalable protein alternatives. Microbial biosynthesis, employing engineered cell factories, represents…
  europepmc 2026 置信度 0.80
• One fungus, two trades: Metabolic breadth couples the ability to kill insects to plant symbiosis.
  europepmc 2026 置信度 0.80
• Bioengineered Exosome-Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut-Liver Crosstalk in Chronic Fatty Liver Disease.
  europepmc 2026 置信度 0.80
• Iron availability as a time-evolving descriptor linking syntrophic metabolic responses and process performance in nano-iron-amended anaerobic systems.
  europepmc 2026 置信度 0.80
• E3 Ubiquitin Ligases in MASH-Associated Liver Fibrosis: Mechanisms and Therapeutic Opportunities.
  europepmc 2026 置信度 0.80
• Urea-NaHCO<sub>3</sub> co-activated biochar enhances biohydrogen production via microbial community restructuring and metabolic pathway redirection.
  europepmc 2026 置信度 0.80
• Engineering-Modulated Molybdenum Enzymes Strategy for Tumor-Specific Metabolic-Immunotherapy.
  europepmc 2026 置信度 0.80
• Myeloperoxidase-Mediated Metabolic Activation of Aristolochic Acid I Aggravates Liver Injury Under Inflammatory Conditions.
  europepmc 2026 置信度 0.80
• Cytochrome P450 3A-mediated metabolic activation of fibleucin from Tinospora sagittata initiates liver injury in mice.
  europepmc 2026 置信度 0.80
• Mechanized Qu-making may contribute to lactic acid bacteria overproliferation in Hongqu rice wine brewing: Insights into microbial dysbiosis and flavor quality deterioration.
  europepmc 2026 置信度 0.80
• Formaldehyde metabolism in the biocatalytic upgrading of lignin.
  europepmc 2026 置信度 0.80
• Metabolic engineering of <i>Escherichia coli</i> for the biosynthesis of nylon 6 and nylon 6,6 monomers.
  europepmc 2026 置信度 0.80
• Sulfamethoxazole and acetaminophen increase methane yield while exerting different effects on key metabolic pathways and antibiotic resistance gene dynamics during anaerobic digestion.
  europepmc 2026 置信度 0.80
• Molecular Access Engineering for Microbial Biocatalysis: from Enzyme Tunnels to Microbial Cell Factories.
  europepmc 2026 置信度 0.80
• Targeted NIR-II Photothermal Therapy Enabled by Bioorthogonal Click Reaction With Olympicenyl Radical Nanoparticles.
  europepmc 2026 置信度 0.80
• Therapeutic targeting of brain bioenergetics in Alzheimer's disease addressing insulin resistance, glucose hypometabolism, and mitochondrial dysfunction.
  europepmc 2026 置信度 0.80
• Bio-Orthogonally Click-Assembled Macrophage Spheroids on Micropatterned Scaffolds for Sustained M1 Polarization and Antitumor Function.
  europepmc 2026 置信度 0.80
• Photosynthetic production of glutamine through metabolic analysis-based engineering of <i>Picosynechococcus</i> sp. PCC 7002.
  europepmc 2026 置信度 0.80
• Ethnomedicinal Uses, Phytochemistry and Bioactivities of Halophytes and Salt-Tolerant Plants with Potential Against Metabolic Syndrome: A Comprehensive Review.
  europepmc 2026 置信度 0.80
• A revised ribosome-antibiotic model with proportional feedback synthesis explains recovery from translation inhibition.
  europepmc 2026 置信度 0.80
• CYP2C19-mediated metabolic activation and OAT3/P-gp-associated transport contribute to Dioscorea bulbifera L.-induced hepatotoxicity.
  europepmc 2026 置信度 0.80
• Corrigendum to "Diosgenin as a substitute for cholesterol alleviates NAFLD by affecting CYP7A1 and NPC1L1-related pathway" [Phytomedicine, 125 (2024), 155299].
  europepmc 2026 置信度 0.80
• From polygenic risk to functional genomics: a framework for precision gynecological disease modeling.
  europepmc 2026 置信度 0.80
• Engineering Extracellular Vesicles for Anti-Aging Therapy: Mechanisms, Applications, and Perspectives.
  europepmc 2026 置信度 0.80
• Spatially resolved proteomics provides insights into the normal-dysplasia-tumor continuum in oral squamous cell carcinoma.
  europepmc 2026 置信度 0.80
• E3 Ubiquitin ligases molecular strategies against proteostasis defects of imperfect ageing.
  europepmc 2026 置信度 0.80
• Cryo-EM structure of Escherichia coli HPII catalase serendipitously co-purified with a recombinant adhesin construct.
  europepmc 2026 置信度 0.80
• Smoking reshapes systemic metabolic coordination across lung cancer subtypes: a multicenter total-body <sup>18</sup>F-FDG PET/CT study with tumor habitat imaging.
  europepmc 2026 置信度 0.80
• Hydrogen supplementation improves glucose-based n-caproate production in Caproiciproducens galactitolivorans with reverse β-oxidation-associated redox remodeling.
  Medium-chain carboxylic acids, such as n-caproate, are attractive sustainable platform chemicals. However, their microbial production is often limited by electron availability and low product selectivity. This study investigated the effect of hydrogen suppleme…
  europepmc 2026 置信度 0.80
• Divergent mitochondrial and fibrotic signatures in atrial fibrillation: insights from organoids and GEO data.
  europepmc 2026 置信度 0.80
• Editorial: Biodegradation of agricultural pesticides.
  europepmc 2026 置信度 0.80
• Maximizing Nanoscale Disorder in Block Copolymers for Orientation-Independent SERS Platform Toward Non-Invasive Diagnostics.
  europepmc 2026 置信度 0.80
• Single-electrode simultaneous detection of tonic dopamine and serotonin <i>in vivo</i> using an interleaved cyclic square wave voltammetry approach.
  europepmc 2026 置信度 0.80
• Global transcriptional rewiring and dual-compartment engineering for efficient 3-hydroxypropionic acid production in Saccharomyces cerevisiae.
  europepmc 2026 置信度 0.80
• Microbial Inulinases: Characterization, Properties, and Potential Contribution to Metabolic and Nutritional Health.
  europepmc 2026 置信度 0.80
• Fecal Microbiome and Serum Metabolome Profiles of the Ovarian Failure Mouse Model.
  europepmc 2026 置信度 0.80
• Temporal interpretation of physiologic group contributions for ICU mortality prediction.
  europepmc 2026 置信度 0.80
• BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer.
  europepmc 2026 置信度 0.80
• Corrigendum to "Diosgenin as a substitute for cholesterol alleviates NAFLD by affecting CYP7A1 and NPC1L1-related pathway" [Phytomedicine, 125 (2024), 155299].
  europepmc 2026 置信度 0.80
• Exogenous quorum sensing signal enhances central energy metabolism to fuel biofilm formation and denitrification on microplastics.
  europepmc 2026 置信度 0.80
• Safe and resource-aware microbial design for food production.
  europepmc 2026 置信度 0.80
• Optimizing rhamnolipid biosynthesis: evaluating predictive methods using <i>Pseudomonas aeruginosa</i> mutants.
  europepmc 2026 置信度 0.80
• ATTNSOM: learning cross-isoform attention for cytochrome P450 site-of-metabolism prediction.
  europepmc 2026 置信度 0.80
• Mesenchymal Stem Cell-Derived Exosomes Improve Aging-Related Changes in Liver Lipid Metabolism by Enhancing Autophagy.
  europepmc 2026 置信度 0.80
• Different brain spatial metabolic patterns characterizing different subtypes of multiple system atrophy.
  europepmc 2026 置信度 0.80
• Seamless human electronics interfacing through advanced skin attachable and implantable sensor technologies.
  europepmc 2026 置信度 0.80
• Multi-omics and metabolic flux modeling reveal that macrophage CYP27A1-derived 26-hydroxycholesterol drives immunosuppression and cancer malignancy.
  europepmc 2026 置信度 0.80
• Evaluation of ornithogalum sigmoideum extract-induced cytotoxicity and expression of xenobiotic metabolism-related genes in HT29 cells.
  europepmc 2026 置信度 0.80
• Beyond GLP-1 Agonists: Plant-Derived Bioactive Compounds as Adjunctive Strategies for Obesity Management.
  europepmc 2026 置信度 0.80
• Croaker Fish Bone-Derived Hydroxyapatite as a Sustainable Source for 3D-Printed Scaffolds for Bone Regeneration.
  europepmc 2026 置信度 0.80
• Dendrobium nobile Lindl. alleviates acute alcoholic liver injury in mice by modulating bile acid metabolism via the enterohepatic circulation.
  europepmc 2026 置信度 0.80
• Ethnopharmacological landscape of Azadirachta indica (Neem): Phytochemical diversity bridging traditional heritage and modern medicine.
  europepmc 2026 置信度 0.80
• Improving protein secretion in yeasts: From secretion leader engineering and AI-driven prediction to bioprocess performance.
  Yeast is widely used for recombinant protein production because it supports eukaryotic protein expression and high-cell-density cultivation. Efficient secretion depends on secretion leaders, short N-terminal sequences that direct nascent polypeptides into the …
  europepmc 2026 置信度 0.80
• Strain-promoted click chemistry boosts microbubbles for targeted ultrasound imaging and cancer chemotherapy.
  europepmc 2026 置信度 0.80
• From pathophysiology to therapy: molecular mechanisms of stem cell and extracellular vesicle-mediated repair in diabetic peripheral neuropathy.
  europepmc 2026 置信度 0.80
• Modular pathway engineering enables gram-scale de novo biosynthesis of narirutin in yeast.
  europepmc 2026 置信度 0.80
• Carbon-Mediated Rechargeable Operation for Light-Driven Ammonia Production Using Quantum Dot-Azotobacter vinelandii Hybrids.
  europepmc 2026 置信度 0.80
• Differential Regulation of Pre-Harvest Sprouting by <i>OsERF1</i> and <i>OsERF94</i> Through Hormone Signaling and Metabolic Reprogramming in Rice.
  europepmc 2026 置信度 0.80
• TMEM135 deficiency prevents intestinal lipid accumulation by coordinating lipid uptake and oxidation through ELOVL6-mediated PPARα activation.
  europepmc 2026 置信度 0.80
• Matrix-Aware Electrochemical Sensing: A Neural Network Approach to Deciphering Medium-Specific Surface Dynamics.
  Accurate monitoring in complex biofluids remains challenging due to unpredictable skin - electrode interfacial interference and matrix-dependent impedance variations. Here, we present an intelligent enzymatic microneedle platform that achieves calibration-effi…
  europepmc 2026 置信度 0.80
• Aging time-dependent non-volatile chemical and microbial dynamics in Pericarpium Citri Reticulatae 'Chachiensis' from multi-regional origins.
  europepmc 2026 置信度 0.80
• Development and temporal validation of a prediction model for live birth in infertile women with polyendocrine metabolic ovarian syndrome: a retrospective cohort study.
  europepmc 2026 置信度 0.80
• Immunomodulatory Nanozymes as Programmable Redox-Immune Set-Point Regulators.
  europepmc 2026 置信度 0.80
• Corrigendum to "Exploring community succession and metabolic changes in corn gluten meal-bran mixed wastes during fermentation" [J. Environ. Manag. 366 (2024) 121684].
  europepmc 2026 置信度 0.80
• Air-liquid interface-centered oxygen engineering in human brain organoids: intact, sliced, and microfluidic extensions.
  europepmc 2026 置信度 0.80
• The role of coumarin biosynthesis in modulating plant drought responses: insights from PpBMT overexpression in Arabidopsis.
  europepmc 2026 置信度 0.80
• Temporal decoupling between cyanobacterial inactivation and microcystin release under radiation-induced oxidative stress: implications of toxin dynamics in aquatic environments.
  europepmc 2026 置信度 0.80
• Primary Cilia as Integrative Hubs of Metabolic Signaling in Type 2 Diabetes: Inter-Organ Evidence From Central, Peripheral, and Pancreatic Islet Tissues.
  europepmc 2026 置信度 0.80
• Overlapping Diabetes- and CKD-Driven Vascular Phenotypes of Peripheral Artery Disease: A Limb-First Framework for Chronic Limb-Threatening Ischemia.
  europepmc 2026 置信度 0.80
• Gut microbiota mediates dietary adaptation across spatially varying diets in the endangered Przewalski's gazelle (Procapra przewalskii).
  europepmc 2026 置信度 0.80
• Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Diabetic β-Cell Apoptosis and Dedifferentiation by Delivering miR-4436.
  europepmc 2026 置信度 0.80
• Nanomedicine-based cancer immunotherapy: translational barriers, mechanistic strategies, and future perspectives.
  Nanomedicine-based cancer immunotherapy integrates nanotechnology with immune modulation, representing a promising strategy to improve both the efficacy and safety of cancer treatment. Despite substantial preclinical potential, clinical translation is hindered…
  europepmc 2026 置信度 0.80
• Integrated metabolomic and mRNA transcriptomic analyses reveal key metabolites and genes involved in browning of fresh-cut pitaya.
  europepmc 2026 置信度 0.80
• Electrodeposited Janus collagen membrane with tunable barrier protection, controlled degradation, and synergistic immunomodulation for bone regeneration in complex defects.
  europepmc 2026 置信度 0.80
• Horizontal Gene Transfer and Genome Rearrangements Shape Bacterial Adaptation for Bioremediation.
  europepmc 2026 置信度 0.80
• Genomic evidence of ecological flexibility and cross-niche CRISPR spacerome targeting phage-plasmid hybrids in Latilactobacillus curvatus.
  europepmc 2026 置信度 0.80
• A V<sub>2</sub>CTx-MXene@f-MWCNTs nanocomposite-reinforced 3D porous graphene-based flexible patch integrated with microfluidic channels for real-time glucose and ketone monitoring in sweat.
  europepmc 2026 置信度 0.80
• Persistent Cardiovascular Burden and Independent Association Among Cancer Survivors in the United States, 2016 to 2024.
  europepmc 2026 置信度 0.80
• Growth differentiation factor-15 and the incidence, bidirectional progression, and risk prediction of atherosclerotic cardiovascular disease and metabolic dysfunction-associated steatotic liver disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3.
  europepmc 2026 置信度 0.80
• Applying metabolic control strategies to engineered T cell cancer therapies
  crossref Andrea C. Fox, John Blazeck 2024-10-25T02:52:33Z 置信度 0.70
• Consistent biosynthesis of D-glycerate from variable mixed substrates
  crossref Cynthia Ni, Kristala L.J. Prather 2024-01-05T18:14:20Z 置信度 0.70
• Rethinking 13C-metabolic flux analysis – The Bayesian way of flux inference
  crossref Axel Theorell, Johann F. Jadebeck, Wolfgang Wiechert, Johnjoe McFadden 等 2024-04-04T08:50:19Z 置信度 0.70
• Metabolic engineering of CHO cells towards cysteine prototrophy and systems analysis of the ensuing phenotype
  crossref Laura Greenfield, Mariah Brantley, Pauline Geoffroy, Jeffrey Mitchell 等 2024-06-20T03:21:08Z 置信度 0.70
• -Substituted 3-hydroxy acid production from glucose in Escherichia coli
  crossref K'yal R. Bannister, Kristala L.J. Prather 2024-09-21T06:28:53Z 置信度 0.70
• Corrigendum to “Cyclo-diphenylalanine Production in Aspergillus nidulans through Stepwise Metabolic Engineering” [Metab. Eng. 82 (2024) 147–156]
  crossref Xiaolin Liu, Kang Li, Jing Yu, Chuanteng Ma 等 2024-03-11T04:49:48Z 置信度 0.70
• Enabling pathway design by multiplex experimentation and machine learning
  crossref Aashutosh Girish Boob, Junyu Chen, Huimin Zhao 2023-11-30T06:57:35Z 置信度 0.70
• Heterologous biosynthesis of betanin triggers metabolic reprogramming in tobacco
  crossref Xun Jiang, Zhuoxiang Zhang, Xiuming Wu, Changmei Li 等 2024-11-04T08:20:24Z 置信度 0.70
• Metabolic engineering of Escherichia coli for high-level production of the biodegradable polyester monomer 2-pyrone-4,6-dicarboxylic acid
  crossref Fengli Wu, Shucai Wang, Dan Zhou, Shukai Gao 等 2024-03-21T23:45:56Z 置信度 0.70
• Engineering peroxisomal surface display for enhanced biosynthesis in the emerging yeast Kluyveromyces marxianus
  crossref Shane Bassett, Jonathan C. Suganda, Nancy A. Da Silva 2024-11-01T10:50:39Z 置信度 0.70
• Creating new-to-nature carbon fixation: A guide
  crossref Helena Schulz-Mirbach, Beau Dronsella, Hai He, Tobias J. Erb 2023-12-29T17:15:09Z 置信度 0.70
• Cutting-edge developments in plastic biodegradation and upcycling via engineering approaches
  crossref Zeinab Rezaei, Amir Soleimani Dinani, Hamid Moghimi 2024-11-28T09:28:50Z 置信度 0.70
• Unlocking lager's flavour palette by metabolic engineering of Saccharomyces pastorianus for enhanced ethyl ester production
  crossref Nicole X. Bennis, Jimme Bieseman, Jean-Marc G. Daran 2024-08-10T06:19:16Z 置信度 0.70
• Metabolic engineering of Acinetobacter baylyi ADP1 for naringenin production
  crossref Kesi Kurnia, Elena Efimova, Ville Santala, Suvi Santala 2024-11-01T01:12:37Z 置信度 0.70
• Extracting and Ranking Metabolic Pathways from Large Metabolic Networks using Graph Theory and Metabolic Flux Analysis
  crossref 2024-06-26T14:39:18Z 置信度 0.70
• Metabolic engineering of Saccharomyces cerevisiae for de novo production of odd-numbered medium-chain fatty acids
  crossref Genlai Dong, Ying Zhao, Wentao Ding, Shijie Xu 等 2024-02-05T07:21:25Z 置信度 0.70
• Metabolic impact of heterologous protein production in Pseudomonas putida: Insights into carbon and energy flux control
  crossref Philippe Vogeleer, Pierre Millard, Ana-Sofia Ortega Arbulú, Katharina Pflüger-Grau 等 2023-11-02T18:14:32Z 置信度 0.70
• Engineering yeasts to Co-utilize methanol or formate coupled with CO2 fixation
  crossref Yuanke Guo, Rui Zhang, Jing Wang, Ruirui Qin 等 2024-05-15T20:57:26Z 置信度 0.70
• Production of (R)-citramalate by engineered Saccharomyces cerevisiae
  crossref Ryosuke Mitsui, Akihiko Kondo, Tomokazu Shirai 2024-08-10T02:44:10Z 置信度 0.70
• YaliCMulti and YaliHMulti: Stable, efficient multi-copy integration tools for engineering Yarrowia lipolytica
  crossref Mengsu Liu, Junjun Wu, Mingyu Yue, Yang Ning 等 2024-01-13T21:06:20Z 置信度 0.70
• Machine learning predicts system-wide metabolic flux control in cyanobacteria
  crossref Amit Kugler, Karin Stensjö 2024-02-21T12:04:45Z 置信度 0.70
• Engineering and evolution of the complete Reductive Glycine Pathway in Saccharomyces cerevisiae for formate and CO2 assimilation
  crossref Viswanada R. Bysani, Ayesha S. Alam, Arren Bar-Even, Fabian Machens 2023-11-30T06:57:49Z 置信度 0.70
• Engineering a solar formic acid/pentose (SFAP) pathway in Escherichia coli for lactic acid production
  crossref Yajing Zhang, Tao Sun, Linqi Liu, Xupeng Cao 等 2024-04-15T14:09:07Z 置信度 0.70
• Evaluation of enzyme-constrained genome-scale model through metabolic engineering of anaerobic co-production of 2,3-butanediol and glycerol by Saccharomyces cerevisiae
  crossref Gustav Sjöberg, Alīna Reķēna, Matilda Fornstad, Petri-Jaan Lahtvee 等 2024-02-02T00:56:59Z 置信度 0.70
• Rewiring Saccharomyces cerevisiae metabolism for optimised Taxol® precursors production
  crossref Behnaz Nowrouzi, Pablo Torres-Montero, Eduard J. Kerkhoven, José L. Martínez 等 2023-11-16T00:59:59Z 置信度 0.70
• Efficient utilization of xylose requires CO2 fixation in Synechococcus elongatus PCC 7942
  crossref Shannon R. Pressley, Jake N. Gonzales, Shota Atsumi 2024-09-23T13:09:51Z 置信度 0.70
• A multiscale hybrid modelling methodology for cell cultures enabled by enzyme-constrained dynamic metabolic flux analysis under uncertainty
  crossref Oliver Pennington, Sebastián Espinel Ríos, Mauro Torres Sebastian, Alan Dickson 等 2024-10-30T16:09:09Z 置信度 0.70
• Growth-coupled production of L-isoleucine in Escherichia coli via metabolic engineering
  crossref Nan Lu, Minhua Wei, Xuejing Yang, Yingzi Li 等 2024-10-14T02:26:19Z 置信度 0.70
• Adaptive laboratory evolution and metabolic engineering of Cupriavidus necator for improved catabolism of volatile fatty acids
  crossref Eric C. Holmes, Alissa C. Bleem, Christopher W. Johnson, Gregg T. Beckham 2024-10-28T07:36:52Z 置信度 0.70
• Cyclo-diphenylalanine production in Aspergillus nidulans through stepwise metabolic engineering
  crossref Xiaolin Liu, Kang Li, Jing Yu, Chuanteng Ma 等 2024-02-20T02:51:56Z 置信度 0.70

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