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• Nature Inspired Small Molecules for Chemical Biology
  Abstract Chemical biology and drug discovery are instrumental sciences to address unmet medical needs and to gain a deeper understanding of normal and disease state biology in mammalian systems. Unlike most genetic tools, the small molecule modulation of biolo…
  openalex Kamal Kumar, Herbert Waldmann 2018-10-18 置信度 0.72 Chemical biologyChemical spaceSmall moleculeNatural productDrug discovery
• Programming Next‐Generation Synthetic Biosensors by Genetic Circuit Design
  Synthetic biology employs engineering principles to construct genetic circuits with customized functionality, empowering unprecedented control over biological systems. By harnessing this capability to precisely manipulate biological systems, synthetic biosenso…
  openalex Yuanli Gao, Cheng Huang, Jiaxuan Deng, Lei Wang 等 2026-02-08 置信度 0.72 Synthetic biologyBiosensorComputer scienceNanotechnologyBioproduction
• Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.
  Human melanoma cell line MZ2-MEL expresses several antigens recognized by autologous cytolytic T lymphocyte (CTL) clones. We reported previously the identification of a gene, named MAGE-1, that codes for one of these antigens named MZ2-E. We show here that ant…
  openalex Béatrice Gaugler, Benoı̂t Van den Eynde, Pierre van der Bruggen, Pedro Romero 等 1994-03-01 置信度 0.72 CTL*AntigenBiologyExonHuman leukocyte antigen
• An outlook on structural biology after A lpha F old: tools, limits and perspectives
  AlphaFold and similar groundbreaking, AI-based tools, have revolutionized the field of structural bioinformatics, with their remarkable accuracy in ab-initio protein structure prediction. This success has catalyzed the development of new software and pipelines…
  openalex Serena Rosignoli, Maddalena Pacelli, Francesca Manganiello, Alessandro Paiardini 2024-09-23 置信度 0.72 Context (archaeology)Computer scienceStructural bioinformaticsField (mathematics)Software
• Status and Prospects of Botanical Biopesticides in Europe and Mediterranean Countries
  Concerning human and environmental health, safe alternatives to synthetic pesticides are urgently needed. Many of the currently used synthetic pesticides are not authorized for application in organic agriculture. In addition, the developed resistances of vario…
  openalex Fatma Acheuk, Shereen Basiouni, Awad A. Shehata, Katie Dick 等 2022-02-15 置信度 0.72 BiopesticidePesticideCrop protectionAgricultureBiotechnology
• DASH : a versatile and high‐capacity gene stacking system for plant synthetic biology
  DNA assembly systems based on the Golden Gate method are popular in synthetic biology but have several limitations: small insert size, incompatibility with other cloning platforms, DNA domestication requirement, generation of fusion scars, and lack of post-ass…
  openalex Chengsong Zhao, Anna N. Stepanova, José M. Alonso 2025-06-10 置信度 0.72 BiologyDashStackingComputational biologyGene
• Novel Insights into the Biotechnological Production of Haematococcus pluvialis-Derived Astaxanthin: Advances and Key Challenges to Allow Its Industrial Use as Novel Food Ingredient
  Astaxanthin shows many biological activities. It has acquired a high economic potential and its current market is dominated by its synthetic form. However, due to the increase of the health and environmental concerns from consumers, natural forms are now prefe…
  openalex Samuel Jannel, Yanis Caro, Marc Bermudes, Thomas Petit 2020-10-10 置信度 0.72 Haematococcus pluvialisAstaxanthinIngredientPluvialisBiotechnology
• The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
  openalex Steven E. Kahn 2003-01-01 置信度 0.72 Insulin resistanceType 2 diabetesInsulinInternal medicineEndocrinology
• Plastics and insects: Records of ants entangled in synthetic fibres
  Abstract Plastic pollution is an emerging environmental risk, as it may negatively impact many species. However, much remains to be studied in terrestrial invertebrates, since the information in which this pollutant interacts with insects and soil fauna in nat…
  openalex Álvaro Luna, Armand Rausell‐Moreno, J. Manuel Vidal‐Cordero 2023-09-18 置信度 0.72 LasiusHymenopteraBiologyFaunaEcology
• Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease.
  Alzheimer's Disease (AD) is the most common of the senile dementias, the prevalence of which is increasing rapidly, with a projected 14 million affected worldwide by 2025. The signal transduction mechanisms that underlie the learning and memory derangements in…
  openalex Kelly T. Dineley, Marcus A. Westerman, Duc Thien Bui, Karen A. Bell 等 2001-06-15 置信度 0.72 MAPK/ERK pathwayDownregulation and upregulationCREBProtein kinase ASignal transduction
• Bacterial Cellulose for Sustainable Food Packaging: Production Pathways, Structural Design, and Functional Modification Strategies
  Global concern over food waste and plastic pollution highlights the urgent need for sustainable, high-performance materials that can replace petroleum-based plastics. Bacterial cellulose (BC), a biopolymer synthesized through microbial fermentation by Komagata…
  openalex Ronagul Turganova, Rysgul N. Tuleyeva, Ayaz M. Belkozhayev, Nargiz N. Gizatullina 等 2025-11-28 置信度 0.72 Bacterial celluloseCelluloseBiopolymerBiochemical engineeringEnvironmental science
• Synthetic photorespiratory bypass more stably increases potato yield per plant by improving photosynthesis
  The bioengineering of photorespiration has emerged as a key target for improving photosynthesis and crop yield. In our previous study, two photorespiratory bypasses, GOC and GCGT, were successfully established in rice, and the transgenic plants exhibited incre…
  openalex Xiu-Ling Lin, Yuming Long, Zhen Yao, Boran Shen 等 2025-04-02 置信度 0.72 PhotorespirationPhotosynthesisBiologyYield (engineering)Agronomy
• Advanced Materials From Fungal Mycelium: Fabrication and Tuning of Physical Properties
  In this work is presented a new category of self-growing, fibrous, natural composite materials with controlled physical properties that can be produced in large quantities and over wide areas, based on mycelium, the main body of fungi. Mycelia from two types o…
  openalex Muhammad Haneef, Luca Ceseracciu, Claudio Canale, Ilker S. Bayer 等 2017-01-24 置信度 0.72 MyceliumCelluloseChitinPolysaccharidePleurotus ostreatus
• Designing Tunable DNA Condensates to Control Membrane Budding Transformation in Synthetic Cells
  Wetting interactions between biomolecular condensates and lipid membranes have demonstrated great potential to induce large-scale membrane transformations in synthetic cells. However, the ability to functionalize existing condensates and control their interact…
  openalex Nastasja Kaletta, Sophia Burick, Yusuf Qutbuddin, Petra Schwille 2025-06-27 置信度 0.72 MembraneWettingVesicleNanotechnologyLinker
• Overexpression of glut-1 glucose transporter in human breast cancer an immunohistochemical study
  BACKGROUND: Breast cancers have higher than normal glucose metabolism, but the mechanism of glucose entry into these tumors is not well understood. METHODS: The expression of five facilitative glucose transporters, Glut-1 (erythrocyte type), Glut-2 (liver type…
  openalex Raya S. Brown, Richard L. Wahl 1993-11-15 置信度 0.72 Glucose transporterImmunohistochemistryBreast cancerMedicineGlucose Transporter Type 1
• Exploring the world of small proteins in plant biology and bioengineering
  Small proteins are ubiquitous in all kingdoms of life. MicroProteins, initially characterized as small proteins with protein interaction domains that enable them to interact with larger multidomain proteins, frequently modulate the function of these proteins. …
  openalex Louise Petri, Anne Van Humbeeck, Huanying Niu, Casper Ter Waarbeek 等 2024-10-14 置信度 0.72 BiologyComputational biologyFunction (biology)Sequence homologyHomology (biology)
• Modulation of Protein–Protein Interactions with Molecular Glues in a Synthetic Condensate Platform
  Misregulation of protein-protein interactions (PPIs) underlies many diseases; hence, molecules that stabilize PPIs, known as molecular glues, are promising drug candidates. Identification of novel molecular glues is highly challenging among others because clas…
  openalex Thijs W. van Veldhuisen, Renske M. J. Dijkstra, Auke A. Koops, Peter J. Cossar 等 2025-01-28 置信度 0.72 ChemistryModulation (music)BiophysicsCombinatorial chemistryComputational biology
• ortho ‐Boronic Acid Carbonyl Compounds and Their Applications in Chemical Biology**
  Iminoboronates and diazaborines are related classes of compounds that feature an imine ortho to an arylboronic acid (iminoboronate) or a hydrazone that cyclizes with an ortho arylboronic acid (diazaborine). Rather than acting as independent chemical motifs, th…
  openalex Jack G. Haggett, Dylan W. Domaille 2023-11-15 置信度 0.72 ImineHydrazoneBioconjugationChemistryBoronic acid
• Immunotherapy of prostate cancer using novel synthetic DNA vaccines targeting multiple tumor antigens
  Prostate cancer is a prevalent cancer in men and consists of both indolent and aggressive phenotypes. While active surveillance is recommended for the former, current treatments for the latter include surgery, radiation, chemo and hormonal therapy. It has been…
  openalex Devivasha Bordoloi, Peng Xiao, Hyeree Choi, Michelle Ho 等 2021-03-15 置信度 0.72 Prostate cancerMedicineImmunotherapyAntigenCancer
• AcuSim: A Synthetic Dataset for Cervicocranial Acupuncture Points Localisation
  The locations of acupuncture points (acupoints) differ among human individuals due to variations in factors such as height, weight and fat proportions. However, acupoint annotation is expert-dependent, labour-intensive, and highly expensive, which limits the d…
  openalex Qilei Sun, Jintan Ma, Paul Craig, Linjun Dai 等 2025-04-15 置信度 0.72 AcupunctureComputer scienceInformation retrievalMedicinePathology
• Synthetic peptides activating discoidin domain receptor 2 and collagen‐binding integrins cooperate to stimulate osteoblast differentiation of skeletal progenitor cells
  openalex Chunxi Ge, Yiming Li, Fashuai Wu, X. Peter 等 2023-05-27 置信度 0.72 OsteoblastIntegrinCell biologyDiscoidin domainCollagen receptor
• Cytotoxicity of natural and synthetic cannabinoids and their synergistic antiproliferative effects with cisplatin in human ovarian cancer cells
  Introduction Cannabinoids are reported to suppress the growth of ovarian cancer cells, but it is unclear whether structural modifications can improve their cytotoxic effects. Methods Herein, an investigation into the antiproliferative effects of natural cannab…
  openalex Ying Chen, Huifang Li, Jia‐Bao Liu, Jie Ni 等 2024-11-26 置信度 0.72 CytotoxicityCisplatinOvarian cancerSynthetic cannabinoidsPharmacology
• Enhancing melatonin biosynthesis in crops through synthetic genetic circuits: A strategy for nutritional fortification in soybean and stress resistance in cotton
  Melatonin has gained considerable prominence in the treatment of insomnia that significantly impacts one-third of the global population. The production of melatonin remains challenging due to limitations in current methods. Thus, there is an urgent need for de…
  openalex Yue Shi, Zegang Han, Wanying Zhang, Lu He 等 2025-07-07 置信度 0.72 BiologyMelatoninBiotechnologyPopulationAgronomy
• Xenotransplantation Literature Update: January–June 2025
  In the first half of 2026, xenotransplantation advanced through refinement rather than dramatic new clinical milestones. Clinical studies described graft physiology, immune infiltration, complement activation, coagulation incompatibility, and early function in…
  openalex Kasra Shirini, Joseph M. Ladowski, Niket Harsh, Raphaël Meier 2025-07-01 置信度 0.72 XenotransplantationBiologyMedicineComputational biologyTransplantation
• Detection of RNA modifications
  RNA nucleotide modifications are typically of low abundance and frequently go unnoticed by standard detection methods of molecular biology and cell biology. With a burst of knowledge intruding from such diverse areas as genomics, structural biology, regulation…
  openalex Stefanie Kellner, Jürgen Burhenne, Mark Helm 2010-03-01 置信度 0.72 BiologyComputational biologyNucleotideRNATranscriptome
• From Microbial Consortia to Ecosystem Resilience: The Integrative Roles of Holobionts in Stress Biology
  The holobiont paradigm, conceptualizing host–microbiome assemblages as functionally integrated entities, has fundamentally altered interpretations of adaptive responses to environmental pressures spanning multiple organizational levels. This review synthesizes…
  openalex Maximino Manzanera 2025-09-06 置信度 0.72 HolobiontBiologyEcologyMicrobiomeAdaptation (eye)
• Plant engineering: advances, bottlenecks, and promise
  Plant genetic engineering has transformed our ability to study gene function and improve crop performance, enabling innovations in agriculture, synthetic biology, and biotechnology. Advances in plant transformation technologies have made it possible to introdu…
  openalex Federica Brandizzí, Jenny C. Mortimer, Katherine Denby 2025-04-01 置信度 0.72 Environmental scienceBiochemical engineeringEngineering
• Engineering Multiple Abiotic Stress Tolerance in Canola, Brassica napus
  Impacts of climate change like global warming, drought, flooding, and other extreme events are posing severe challenges to global crop production. Contribution of Brassica napus towards the oilseed industry makes it an essential component of international trad…
  openalex Neeta Lohani, Divya Jain, Mohan B. Singh, Prem L. Bhalla 2020-02-25 置信度 0.72 CanolaBrassicaAbiotic stressAbiotic componentBiology
• The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo
  GPR55 is a G protein-coupled receptor recently shown to be activated by certain cannabinoids and by lysophosphatidylinositol (LPI). However, the physiological role of GPR55 remains unknown. Given the recent finding that the cannabinoid receptors CB(1) and CB(2…
  openalex Lauren S. Whyte, Erik Ryberg, Natalie A. Sims, Susan A. Ridge 等 2009-09-03 置信度 0.72 OsteoclastBone resorptionCannabinoid receptorChemistryCell biology
• The Chemistry and Biology of the Tetrodotoxin Natural Product Family
  Tetrodotoxin is a neurotoxic marine alkaloid, first isolated in 1909 from pufferfish and named after the biological order tetraodontiformes. Since its structural elucidation in 1964, it has attracted the interest of synthetic organic chemists due to its except…
  openalex Benedikt Nißl, Marcel Muelbaier, Francesca Grisoni, Dirk Trauner 等 2025-06-18 置信度 0.72 TetrodotoxinNatural productNatural (archaeology)Product (mathematics)Chemistry
• AI-driven multi-omics integration for multi-scale predictive modeling of genotype-environment-phenotype relationships
  Despite the wealth of single-cell multi-omics data, it remains challenging to predict the consequences of novel genetic and chemical perturbations in the human body. It requires knowledge of molecular interactions at all biological levels, encompassing disease…
  openalex You Wu, Lei Xie 2025-01-01 置信度 0.72 OmicsPhenotypeScale (ratio)Computational biologyGenotype
• Long, Synthetic Staphylococcus aureus Type 8 Capsular Oligosaccharides Reveal Structural Epitopes for Effective Immune Recognition
  High Resolution Image Download MS PowerPoint Slide Staphylococcus aureus is a Gram-positive bacterium that is responsible for severe nosocomial infections. The rise of multidrug-resistant strains, which can pose significant health threats, prompts the developm…
  openalex Kitt Emilie Østerlid, Charlotte Sorieul, Luca Unione, Sizhe Li 等 2025-01-10 置信度 0.72 ChemistryTrisaccharideGlycosidic bondEpitopeImmunogenicity
• An argument for using anaerobes as microbial cell factories to advance synthetic biology and biomanufacturing
  Abstract Anaerobes thrive in the absence of oxygen and are an untapped reservoir of biotechnological potential. Therefore, bioprospecting efforts focused on anaerobic microbial diversity could rapidly uncover new enzymes, pathways, and chassis organisms to dri…
  openalex Thomas S. Lankiewicz, Nathalie H. Elisabeth, David L. Valentine, Michelle O’Malley 2025-02-25 置信度 0.72 BioproductionBiomanufacturingBioprocessBiochemical engineeringBiotechnology
• Design and Immune Profile of Multi-Epitope Synthetic Antigen Vaccine Against SARS-CoV-2: An In Silico and In Vivo Approach
  BACKGROUND: The rapid advancement of the pandemic caused by SARS-CoV-2 and its variants reinforced the importance of developing easy-to-edit vaccines with fast production, such as multi-epitope DNA vaccines. The present study aimed to construct a synthetic ant…
  openalex Maria da Conceição Viana Invenção, Larissa Silva de Macêdo, Ingrid Andrêssa de Moura, Lucas Alexandre Barbosa de Oliveira Santos 等 2025-01-31 置信度 0.72 In silicoEpitopeVirologyImmune systemIn vivo
• Super‐Resolution Fluorescence Microscopy Methods for Assessing Mouse Biology
  Super-resolution (diffraction unlimited) microscopy was developed 15 years ago; the developers were awarded the Nobel Prize in Chemistry in recognition of their work in 2014. Super-resolution microscopy is increasingly being applied to diverse scientific field…
  openalex Jessica Valli, Jeremy Sanderson 2021-08-01 置信度 0.72 MicroscopySTED microscopyResolution (logic)Super-resolution microscopyFluorescence microscope
• Synthetic Biology Biosensors for Global Health Challenges
  Synthetic biologists seek to design, build and modify organisms at the genetic level. One category of engineered organisms, or devices, sense changes in the environment and respond by producing a change in state, such as colour. Two such ‘biosensors’ are in de…
  openalex Rob Smith, Claire Marris, Dominic Berry, Lalitha Sundaram 等 2017-05-03 置信度 0.72 Scope (computer science)Engineering ethicsGlobal healthPolitical scienceEngineering
• Strain Improvement Through Genetic Engineering and Synthetic Biology for the Creation of Microalgae with Enhanced Lipid Accumulation, Stress Tolerance, and Production of High-value
  Microalgae are microscopic, unicellular or simple colony-forming photosynthetic organisms found mainly in freshwater and marine environments. Unlike multicellular macroalgae, microalgae lack complex structures such as roots, stems, and leaves. They perform pho…
  openalex Alebachew Molla, Gedif Meseret Abebe 2025-08-27 置信度 0.72 Synthetic biologyStrain (injury)Lipid accumulationProduction (economics)Value (mathematics)
• Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs
  Multicomponent reactions (MCRs) have emerged as a powerful strategy in synthetic organic chemistry due to their widespread applications in drug discovery and development. MCRs are flexible transformations in which three or more substrates react to form structu…
  openalex Giovanni Graziano, Angela Stefanachi, Marialessandra Contino, Rubén Prieto‐Díaz 等 2023-04-01 置信度 0.72 Drug discoveryBiochemical engineeringCombinatorial chemistryIdentification (biology)Computational biology
• Self-driving laboratories, advanced immunotherapies and five more technologies to watch in 2025
  openalex Michael Eisenstein 2025-01-20 置信度 0.72 SustainabilityEngineeringEcologyBiology
• Cost-Benefit Analysis of Synthetic Nucleic Acid Screening for the UK - Report - CLTR 2025
  openalex Paul-Enguerrand Fady, Cassidy Nelson, Isaac Heron, Richard Bruns 2025-12-16 置信度 0.72 ChemistryNucleic acidBiochemistryDNABiology
• Multifaceted Applications of Microbial Pigments: Current Knowledge, Challenges and Future Directions for Public Health Implications
  Microbial oddities such as versatile pigments are gaining more attention in current research due to their widely perceived applications as natural food colorants, textiles, antimicrobial activities, and cytotoxic activities. This indicates that the future gene…
  openalex Chatragadda Ramesh, Nambali Valsalan Vinithkumar, R. Kirubagaran, Chidambaram Kulandaisamy Venil 等 2019-06-28 置信度 0.72 PathogenicityBiologyBiotechnologyBiochemical engineeringEngineering
• Fundamentals and Recent Developments in Approximate Bayesian Computation
  Bayesian inference plays an important role in phylogenetics, evolutionary biology, and in many other branches of science. It provides a principled framework for dealing with uncertainty and quantifying how it changes in the light of new evidence. For many comp…
  openalex Jarno Lintusaari, Michael U. Gutmann, Ritabrata Dutta, Samuel Kaski 等 2016-10-19 置信度 0.72 Approximate Bayesian computationInferenceBayesian inferenceBayesian probabilityComputer science
• Cholecystokinin: Clinical aspects of the new biology
  Cholecystokinin (CCK) is a classic gut hormone that has been known for almost a century to regulate gallbladder emptying, pancreatic enzyme secretion, and gastrointestinal motor activity. In 1968, the CCK structure was identified by Viktor Mutt and Erik Jorpes…
  openalex Jens F. Rehfeld 2025-06-25 置信度 0.72 CholecystokininHormoneEnteroendocrine cellParacrine signallingMedicine
• AI and Robotics in Agriculture: A Systematic and Quantitative Review of Research Trends (2015–2025)
  The swift integration of AI, robotics, and advanced sensing technologies has revolutionized agriculture into a data-centric, autonomous, and sustainable sector. This systematic study examines the interplay between artificial intelligence and agricultural robot…
  openalex Abderrachid Hamrani, A. Allouhi, Fatma Bouarab, K. Jayachandran 2025-10-21 置信度 0.72 Artificial intelligenceRoboticsField (mathematics)Computer scienceAgriculture
• Harnessing Small RNAs as Synthetic Post-transcriptional Regulators in Bacteria
  Bacteria can respond to environmental changes by expressing small RNAs (sRNAs), which regulate mRNAs by complementary base-pairing. This regulatory mechanism allows bacteria to rapidly adapt their proteome. In recent years, sRNAs have gained attention as bluep…
  openalex Jens Georg, Bork A. Berghoff, Daniel Schindler 2025-07-08 置信度 0.72 Synthetic biologyComputational biologyBacteriaBiologyGenetics
• Applications of Bioinformatics Tools in Medicinal Biology and Biotechnology
  Development of modern medicine necessitates the collection, integration and interpretation of molecular, genomic, and cellular data, together with clinical data. Hence, it produces a significant amount of challenges to bioinformatics. For the investigation and…
  openalex Harshil Shah, Vivek P. Chavda, Moinuddin Soniwala 2023-02-07 置信度 0.72 BiomedicineData scienceComputational biologyTranslational bioinformaticsBiological data
• Meiotic pairing irregularity and homoeologous chromosome compensation cause rapid karyotype variation in synthetic allotetraploid wheat
  Summary Allopolyploidization may initiate rapid evolution due to heritable karyotypic changes. The types and extents of these changes, the underlying causes, and their effects on phenotype remain to be fully understood. Here, we designed experimental populatio…
  openalex Jing Zhao, Juzuo Li, Ruili Lv, Bin Wang 等 2023-05-10 置信度 0.72 BiologyMeiosisGeneticsChromosomeKaryotype
• Harnessing apomixis: natural mechanisms and synthetic innovations for advancing crop and forage breeding
  Apomixis, a reproductive mechanism that enables clonal seed production, generates progeny genetically identical to the maternal parent. In plant breeding, sexual reproduction can enhance traits through genetic recombination and hybrid vigor, yet trait segregat…
  openalex Shuyi Hu, Xiaoyun Han, Lei Tian, Kejian Wang 等 2025-07-16 置信度 0.72 BiologyApomixisForageCropAgroforestry
• Sex‐specific behavioural, metabolic, and immunohistochemical changes after repeated administration of the synthetic cannabinoid AKB48 in mice
  Abstract Background and Purpose AKB48 is a synthetic cannabinoid illegally sold for its psychoactive cannabis‐like effects that have been associated with acute intoxication and whose effects are poorly known. Experimental Approach Using a behavioural, neuroche…
  openalex Giorgia Corli, E. Roda, Micaela Tirri, Sabrine Bilel 等 2023-12-27 置信度 0.72 CannabinoidCannabinoid receptorNeurochemicalInternal medicineEndocrinology
• A Review of Recent Progress in Synthetic Polymer Surface Coatings for the Prevention of Biofilm Formation
  Bacterial adhesion and the subsequent formation of biofilms and biofouling have significant economic and health impacts across all sectors. They are especially impactful in industrial corrosion, healthcare, food processing, agriculture, and waste and drinking …
  openalex Adrienne Shea, Matthew T. Bernards 2025-06-24 置信度 0.72 BiofoulingBiofilmAdhesionPolymerNanotechnology
• Recent advances in 3D bioprinting of vascularized tissues
  3D bioprinting is a technology that combines computing science, biology and material engineering. It has been extensively explored to fabricate 3D vascularized constructs for tissue engineering. This scalable, reproducible and highly precise fabrication techno…
  openalex Yi Zhang, Piyush Kumar, Songwei Lv, Di Xiong 等 2020-12-10 置信度 0.72 3D bioprintingBiofabricationTissue engineeringNanotechnologyMaterials science
• A synthetic model of bioinspired liposomes to study cancer-cell derived extracellular vesicles and their uptake by recipient cells
  Extracellular vesicles (EVs) are secreted by most cell types and play a central role in cell-cell communication. These naturally occurring nanoparticles have been particularly implicated in cancer, but EV heterogeneity and lengthy isolation methods with low yi…
  openalex Rubén R. López, Chaymaa Zouggari Ben El Khyat, Yunxi Chen, Thupten Tsering 等 2025-03-11 置信度 0.72 LiposomeExtracellular vesiclesVesicleCell biologyCancer cell
• Cell-Membrane-Anchored Synthetic Dynamic DNA Circuits for Signaling Transient Cell Migration
  in which each includes the antimesenchymal epithelial transition (Met) receptor aptamer sequence is anchored within MCF-7 cells to emulate the natural signaling network on the live cell membrane. Subjecting the membrane-integrated circuit to an auxiliary fuel …
  openalex Nina Lin, Yu Ouyang, Yunlong Qin, Songqin Liu 等 2025-09-12 置信度 0.72 ChemistryBiophysicsIntracellularTransient (computer programming)DNA
• antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation
  Microorganisms synthesize small bioactive compounds through their secondary or specialized metabolism. Those compounds play an important role in microbial interactions and soil health, but are also crucial for the development of pharmaceuticals or agrochemical…
  openalex Kai Blin, Simon J. Shaw, Lisa Vader, Judit Szenei 等 2025-04-17 置信度 0.72 Nonribosomal peptideBiologyGene clusterGenomeComputational biology
• The Human Plastiphere: A Bioparticulate System Challenging Microplastic Risk Assessment and Governance
  The infiltration of microplastics (MPs) into human tissues represents a paradigm shift in environmental health, transforming external pollution into internal biological integration. Drawing on 90 clinical studies (2016-2025), we define the human plastiphere as…
  openalex Shruti Venkata Chari, Gurusamy Kutralam-Muniasamy 2025-10-01 置信度 0.72 MicroplasticsRisk analysis (engineering)Risk assessmentHuman healthCorporate governance
• Nanomaterials for Neural Interfaces
  Abstract This review focuses on the application of nanomaterials for neural interfacing. The junction between nanotechnology and neural tissues can be particularly worthy of scientific attention for several reasons: (i) Neural cells are electroactive, and the …
  openalex Nicholas A. Kotov, Jessica O. Winter, Isaac P. Clements, Edward Jan 等 2009-07-09 置信度 0.72 InterfacingNanotechnologyMaterials scienceNanomaterialsNeural Prosthesis
• BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality
  The discovery ofBRCA1andBRCA2as tumor susceptibility genes and their role in genome maintenance has transformed our understanding of hereditary breast and ovarian cancer. This review traces the evolution of BRCA1/2 research over the past 30 years, highlighting…
  openalex Anna Khalizieva, Sarah C. Moser, Peter Bouwman, Jos Jonkers 2024-11-07 置信度 0.72 BiologySynthetic lethalityLethalityBRCA2 ProteinCancer
• Quantitative Measurement of Molecular Permeability to a Synthetic Bacterial Microcompartment Shell System
  Naturally evolved and synthetically designed forms of compartmentalization benefit encapsulated function by increasing local concentrations of substrates and protecting cargo from destabilizing environments and inhibitors. Crucial to understanding the fundamen…
  openalex Eric J. Young, Henning Kirst, Matthew E. Dwyer, Josh V. Vermaas 等 2025-01-14 置信度 0.72 Computational biologySynthetic biologyBiologyPermeability (electromagnetism)Biochemical engineering
• Terminally exhausted CD8+ T cells in solid tumors: biology, biomarker potential and translational tools for precision oncology
  Terminally exhausted CD8 + T cells (Ttex) are emerging as clinically relevant immune subsets across solid tumors, marked by sustained inhibitory receptor expression, loss of TCF1, and limited proliferative capacity. Once considered functionally inert, Ttex are…
  openalex Xuejun Guo, Shuhan Ma, Jingwen Wang, Yilin Fu 等 2026-01-12 置信度 0.72 MedicineMultiplexBiomarkerImmunotherapyCancer research
• Characterization and orthogonality assessment of two quorum sensing systems for synthetic biology applications
  Quorum sensing systems have a broad range of applications within the field of synthetic biology. However, a bottleneck is the optimization and tuning of these systems due to the lack of standardization and complete characterization. In this research, two quoru…
  openalex Jasmine De Baets, Brecht De Paepe, Marjan De Mey 2025-08-19 置信度 0.72 OrthogonalityQuorum sensingCharacterization (materials science)Computational biologyBiology
• Using Synthetic Health Care Data to Leverage Large Language Models for Named Entity Recognition: Development and Validation Study
  BACKGROUND: Named entity recognition (NER) plays a vital role in extracting critical medical entities from health care records, facilitating applications such as clinical decision support and data mining. Developing robust NER models for low-resource languages…
  openalex Hendrik Šuvalov, Mihkel Lepson, Veronika Kukk, Maria Malk 等 2025-01-31 置信度 0.72 PreprintLeverage (statistics)Health careData scienceComputer science
• Iterative SCRaMbLE for engineering synthetic genome modules and chromosomes
  Saccharomyces cerevisiae is closing-in on the first synthetic eukaryotic genome with genome-wide redesigns, including LoxPsym site insertions that enable inducible genomic rearrangements in vivo via Cre recombinase through SCRaMbLE (Synthetic Chromosome Recomb…
  openalex Xinyu Lu, Klaudia Ciurkot, Glen-Oliver F. Gowers, W. M. Shaw 等 2025-08-07 置信度 0.72 GenomeSynthetic biologyComputational biologyBiologyMetabolic engineering
• Current progress in synthetic and medicinal chemistry of pyrazole hybrids as potent anticancer agents with SAR studies
  Abstract Background One of the most serious and potentially hazardous diseases that trouble the globe today is cancer. Among various cancer treatment options, chemotherapy is currently one of the most efficient ways to remove cancer. Heterocycles play a pivota…
  openalex Bhupender Nehra, Manoj Kumar, Viney Chawla, Pooja A. Chawla 2025-06-16 置信度 0.72 PyrazoleChemistryBiochemical engineeringCombinatorial chemistryComputational biology
• Characterising a New Cannabis Trend: Extensive Analysis of Semi‐Synthetic Cannabinoid‐Containing Seizures From Germany
  ABSTRACT In May 2022, semi‐synthetic cannabinoids (SSC) appeared on the European drug market, claiming to offer a legal alternative with cannabimimetic effects. Since then, the use of hexahydrocannabinol (HHC) has quickly become very popular and derivatives, a…
  openalex Marica Hundertmark, Laura Besch, J. Röhrich, Tanja Germerott 等 2025-03-19 置信度 0.72 Synthetic cannabinoidsCannabisCannabinoidChemistryMedicine
• Advances in the cell biology of the trafficking and processing of amyloid precursor protein: impact of familial Alzheimer's disease mutations
  The production of neurotoxic amyloid-β peptides (Aβ) is central to the initiation and progression of Alzheimer's disease (AD) and involves sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. APP and the secretases are transmembra…
  openalex Jingqi Wang, Lou Fourrière, Paul A. Gleeson 2024-09-20 置信度 0.72 Amyloid precursor proteinAmyloid precursor protein secretaseAlpha secretaseIntracellularP3 peptide
• Arboviral Diseases in a Changing World: Evolutionary Dynamics, Host–Vector Interactions, and Novel Control Strategies
  Introduction: Arboviral diseases, transmitted by hematophagous arthropods such as mosquitoes and ticks, represent an escalating global public health challenge. The resurgence and geographic spread of arboviruses particularly dengue virus, Zika virus, chikungun…
  openalex Ebrahim Abbasi 2025-09-16 置信度 0.72 Multidisciplinary approachWarrantControl (management)Vector (molecular biology)Risk analysis (engineering)
• Six Shades of Vascular Smooth Muscle Cells Illuminated by KLF4 (Krüppel-Like Factor 4)
  Multiple layers of vascular smooth muscle cells (vSMCs) are present in blood vessels forming the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to contract and relax, thus modulating blood flow. They also play a crucial role in th…
  openalex Carmen Yap, Arnout Mieremet, Carlie J.M. de Vries, Dimitra Micha 等 2021-09-02 置信度 0.72 KrüppelKLF4AnatomyFactor (programming language)Chemistry
• Machine Learning-assisted Quorum Sensing Monitoring and Control Systems for Precision Gene Regulation: Revolutionizing Synthetic Biology and Autonomous Therapeutic Applications
  openalex Đặng Anh Tuấn, Pham Vu Nhat Uyen 2025-12-19 置信度 0.72 Quorum sensingComputer scienceSynthetic biologyReduction (mathematics)Pseudomonas aeruginosa
• Engineering microbial pathways for production of bio-based chemicals from lignocellulosic sugars: current status and perspectives
  tons. It is an inedible renewable carbonaceous resource that is very rich in pentose and hexose sugars. The ability of microorganisms to use lignocellulosic sugars can be exploited for the production of biofuels and chemicals, and their concurrent biotechnolog…
  openalex Jean François, Ceren Alkım, Nicolas Morin 2020-07-08 置信度 0.72 Metabolic engineeringLignocellulosic biomassBiofuelBiochemical engineeringPentose
• Synthetic heparan sulfate mimics based on chitosan derivatives show broad-spectrum antiviral activity
  Enveloped viruses enter cells by binding to receptors present on host cell membranes, which trigger internalization and membrane fusion. For many viruses, this either directly or indirectly involves interaction with membrane-anchored carbohydrates, such as hep…
  openalex Julia Revuelta, Luciana Rusu, Clara Francés‐Gómez, Elena Trapero 等 2025-03-04 置信度 0.72 Heparan sulfateBroad spectrumSulfateChitosanChemistry
• Recent Advances in the Therapeutic Potential of Cannabinoids Against Gliomas: A Systematic Review (2022–2025)
  ABSTRACT Glioma is the most common and lethal primary brain tumor in adults, with glioblastoma (GBM) representing the most aggressive subtype, characterized by diffuse infiltration, resistance to therapy, and a poor prognosis. Despite standard treatments, surv…
  openalex Farideh Javid, Andrej Belančić, Man Ki Kwok, Yun Wah Lam 2025-08-01 置信度 0.72 MedicineSystematic reviewMEDLINEIntensive care medicineChemistry
• Campesterol Semi‐Synthetic Derivatives as Potential Antibacterial: in vitro and in silico Evaluation
  Abstract In this study, twelve campesterol derivatives (2–13) were prepared by esterification reaction at the hydroxy group in C‐3 and catalytic hydrogenation at the carbon‐carbon double bond in C‐5(6). All obtained compounds were characterized by IR, 1H‐NMR, …
  openalex Francisco Erivaldo Freitas da Silva, Francisco das Chagas Lima Pinto, Otília Deusdênia Loiola Pessoa, Aluísio Marques da Fonseca 等 2023-06-19 置信度 0.72 ChemistryAntibacterial activityEscherichia coliBroth microdilutionStereochemistry
• Performance of abiotic stress-inducible synthetic promoters in genetically engineered hybrid poplar (Populus tremula × Populus alba)
  Abiotic stresses can cause significant damage to plants. For sustainable bioenergy crop production, it is critical to generate resistant crops to such stress. Engineering promoters to control the precise expression of stress resistance genes is a very effectiv…
  openalex Yongil Yang, Yuanhua Shao, Timothy A. Chaffin, Jun Hyung Lee 等 2022-10-18 置信度 0.72 BiologyAbiotic stressAbiotic componentBotanyGenetically modified crops
• Habitat suitability modelling and niche theory
  1 The concept of the ecological niche relates a set of environmental variables to the fitness of species, while habitat suitability models (HSMs) relate environmental variables to the likelihood of occurrence of the species. In spite of this relationship, the …
  openalex Alexandre H. Hirzel, Gwenaëlle Le Lay 2008-07-21 置信度 0.72 NicheEcological nicheEnvironmental niche modellingNiche segregationEcology
• Enzymatic Halogenation: A Timely Strategy for Regioselective C−H Activation
  Halogenating enzymes are increasingly attracting attention for biocatalytic C-H functionalization. Despite its importance for synthetic chemistry, selective introduction of halogens using conventional approaches often remains challenging, whereas biocatalysis …
  openalex Christian Schnepel, Norbert Sewald 2017-05-02 置信度 0.72 HalogenationRegioselectivityChemistryCombinatorial chemistryBiocatalysis
• Beyond the Information Given
  openalex Jerome S. Bruner 2025-05-20 置信度 0.72 Computer science
• Biology Roadmap for Research Infrastructures 2025–2028 by the Swiss Biology Community
  This community roadmap expresses a vision for the future development of biological research in Switzerland and the infrastructure needs identified to realise this vision. It describes four dedicated network infrastructures with a common challenge of comprehens…
  openalex Dani Brunner, Christine Durinx, Msf Erb, Moritz Fischer 等 2021-01-01 置信度 0.72 BiologyData scienceComputational biologyComputer science
• Rational design and characterization of enhanced alcohol-inducible synthetic promoters in Pichia pastoris
  ABSTRACT The C1 and C2 alcohols hold great promise as substrates for biomanufacturing due to their low cost and rich resources. Pichia pastoris is considered a preferred host for methanol and ethanol bioconversion due to its natural utilization of methanol and…
  openalex Qi Liu, Yunhao Li, Liu-fei Tao, Jia-yi Yang 等 2024-12-19 置信度 0.72 Pichia pastorisPromoterRational designSynthetic biologyAlcohol
• Natural and synthetic 5‐(3′‐indolyl)oxazoles: Biological activity, chemical synthesis and advanced molecules
  5-(3'-Indolyl)oxazole moiety is a privileged heterocyclic scaffold, embedded in many biologically interesting natural products and potential therapeutic agents. Compounds containing this scaffold, whether from natural sources or synthesized, have demonstrated …
  openalex Jing‐Rui Liu, Enyu Jiang, Otgonpurev Sukhbaatar, Weihua Zhang 等 2024-08-16 置信度 0.72 OxazoleMoietyChemistryCombinatorial chemistryScaffold
• Mechanism of hormone action The effect of synthetic corticosteroids on liver RNA, and hepatic ribonuclease and ribonuclease inhibitor activities in rats
  openalex N.K. Sarkar 1969-07-01 置信度 0.72 RNase PRNARibonucleaseChemistryMechanism of action
• Bioremediation of Synthetic Dyes by White-Rot Fungi: Enzymatic Mechanisms, Biosorption, and Environmental Applications
  The widespread utilization of synthetic dyes within the textile industry, driven by their chemical recalcitrance and diverse chromatic spectra, constitutes a significant global environmental challenge. Improper discharge of these highly stable effluents into n…
  openalex Anna Carolina Bruno Ferreira, Ygor Velloso Tavares, Nina Rezende Fontana, Thiago Machado Pasin 等 2026-03-26 置信度 0.72 BioremediationLaccaseBioprocessBiochemical engineeringEnvironmental science
• Proteinases in the joint: clinical relevance of proteinases in joint destruction
  Proteinases are involved in essential steps in cartilage and bone homeostasis. Consequently, efforts have been made to establish their potential role in the pathology of rheumatic conditions such as rheumatoid arthritis, osteoarthritis and spondyloarthritis. M…
  openalex Yvonne Rengel, Caroline Ospelt, Steffen Gay 2007-01-01 置信度 0.72 MedicineMatrix metalloproteinaseRheumatoid arthritisRheumatologyOsteoarthritis
• Tumor microenvironment signaling and therapeutics in cancer progression
  Tumor development and metastasis are facilitated by the complex interactions between cancer cells and their microenvironment, which comprises stromal cells and extracellular matrix (ECM) components, among other factors. Stromal cells can adopt new phenotypes t…
  openalex Anshika Goenka, Fatima Khan, Bhupender Verma, Priyanka Sinha 等 2023-04-02 置信度 0.72 Tumor microenvironmentCell biologyCancer researchBiologyCXCL14
• Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation
  For the past 40 years or so, oxidative stress has been increasingly recognized as a contributing factor in aging and in various forms of pathophysiology generally associated with aging. Our view of oxidative stress has been largely "superoxide-centric", as we …
  openalex Brooks M. Hybertson, Bifeng Gao, Swapan K. Bose, Joe M. McCord 2011-08-01 置信度 0.72 Oxidative stressSuperoxide dismutaseBiologyTranscription factorImmune system
• Next-Generation Sequencing — An Overview of the History, Tools, and “Omic” Applications
  Next-generation sequencing (NGS) technologies using DNA, RNA, or methylation sequencing have impacted enormously on the life sciences. NGS is the choice for large-scale genomic and transcriptomic sequencing because of the high-throughput production and outputs…
  openalex Jerzy K. Kulski 2016-01-14 置信度 0.72 DNA sequencingGenomicsBiologyComputational biologySanger sequencing
• Microarray analysis of microRNA expression in the developing mammalian brain
  BACKGROUND: MicroRNAs are a large new class of tiny regulatory RNAs found in nematodes, plants, insects and mammals. MicroRNAs are thought to act as post-transcriptional modulators of gene expression. In invertebrates microRNAs have been implicated as regulato…
  openalex Eric A. Miska, Ezequiel Alvarez-Saavedra, Matthew Townsend, Akira Yoshii 等 2004-08-31 置信度 0.72 BiologyHuman geneticsmicroRNAComputational biologyGenome Biology
• The Multifaceted Role of p53 in Cancer Molecular Biology: Insights for Precision Diagnosis and Therapeutic Breakthroughs
  The protein p53, often referred to as the "guardian of the genome," is essential for preserving cellular balance and preventing cancerous transformations. As one of the most commonly altered genes in human cancers, its impaired function is associated with tumo…
  openalex Bolong Xu, Ayitila Maimaitijiang, Dawuti Nuerbiyamu, Zhengding Su 等 2025-07-27 置信度 0.72 BiologyContext (archaeology)Immune checkpointReprogrammingCancer
• Synthetic Biopolymers
  Synthetic biopolymers are those biobased polymers that can be possibly derived from renewable natural sources and are sustainable as they are biodegradable. The research in the field of synthetic biopolymers is fast progressing, with work on the mode of fabric…
  openalex Reeba Mary Cherian, Rini Thresia Varghese, Jithin Joy, Cintil Jose 等 2024-01-20 置信度 0.72 BiopolymerSynthetic polymerNatural polymersPolymerMaterials science
• Designing a broad-spectrum integrative approach for cancer prevention and treatment
  Targeted therapies and the consequent adoption of "personalized" oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most pat…
  openalex Keith I. Block, Charlotte Gyllenhaal, Leroy Lowe, Amedeo Amedei 等 2015-11-18 置信度 0.72 Broad spectrumTumor microenvironmentCancerMechanism (biology)Personalized medicine
• Recent developments in the synthesis and synthetic applications of borane–amines
  generated borane, salt metathesis, and Lewis base exchange, are discussed in detail with emphasis on recent protocols and borane-ammonia preparation techniques. Applications of borane-amines in organic synthesis where they serve as selective and more easily ha…
  openalex Henry J. Hamann, P. Veeraraghavan Ramachandran 2025-12-11 置信度 0.72 BoraneOrganic synthesisHydroborationDiboraneChemistry
• Systematic modulation of bacterial resource allocation by perturbing RNA polymerase availability via synthetic transcriptional switches
  Gene regulation and its interplay with physiological behaviors are the central topics of modern biology. Classical studies on gene regulation focus intensively on specific regulatory mechanisms of transcription. Nevertheless, the genome-wide impact of RNA poly…
  openalex Manlu Zhu, Xiongfeng Dai 2025-08-06 置信度 0.72 BiologySigma factorRegulation of gene expressionGene expressionRNA polymerase
• Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems
  Novel tissue regeneration strategies are constantly being developed worldwide. Research on bone regeneration is noteworthy, as many promising new approaches have been documented with novel strategies currently under investigation. Innovative biomaterials that …
  openalex Aleksandra Szwed, Przemysław Płociński, Barbara Kupikowska-Stobba, Mateusz M. Urbaniak 等 2023-08-16 置信度 0.72 ScaffoldRegeneration (biology)BiomoleculeBiocompatibilityNanotechnology
• Harnessing synthetic biology to empower a circular plastics economy
  Biotechnology offers unique opportunities for mitigating and upcycling plastic waste with low-intensity bioprocesses. Synthetic biology can further enhance bioprocesses for sustainably dealing with plastic waste and supporting a circular plastics economy. We p…
  openalex Aaron Yip, Michael Weldon, Ida Putu Wiweka Dharmasiddhi, Brian Zubrzycki 等 2025-01-01 置信度 0.72 Circular economySynthetic biologyPlastic wasteBiochemical engineeringSustainability
• Targeting telomerase for its advent in cancer therapeutics
  Telomerase has emerged as an important primary target in anticancer therapy. It is a distinctive reverse transcriptase enzyme, which extends the length of telomere at the 3' chromosomal end, and uses telomerase reverse transcriptase (TERT) and telomerase RNA t…
  openalex Shalini Bajaj, Maushmi S. Kumar, Godefridus J. Peters, YC Mayur 2020-05-11 置信度 0.72 TelomeraseTelomerase reverse transcriptaseTelomereCancerBiology
• Enhancing Wearable Fall Detection System via Synthetic Data
  Deep learning models rely heavily on extensive training data, but obtaining sufficient real-world data remains a major challenge in clinical fields. To address this, we explore methods for generating realistic synthetic multivariate fall data to supplement lim…
  openalex Minakshi Debnath, Sana Alamgeer, Md Shahriar Kabir, Anne H. H. Ngu 2025-07-26 置信度 0.72 Computer scienceSynthetic dataDiscriminative modelArtificial intelligenceMachine learning
• Injectable protease-operated depots of glucagon-like peptide-1 provide extended and tunable glucose control
  Peptide drugs are an exciting class of pharmaceuticals increasingly used for the treatment of a variety of diseases; however, their main drawback is a short half-life, which dictates multiple and frequent injections and an undesirable "peak-and-valley" pharmac…
  openalex Miriam Amiram, Kelli M. Luginbuhl, Xinghai Li, Mark N. Feinglos 等 2013-01-28 置信度 0.72 PeptideProteaseDrug deliveryBiochemistryChemistry
• Computational design of dynamic biosensors for emerging synthetic opioids
  Nitazenes are an emergent class of synthetic opioids that often rival or exceed fentanyl in their potency. These compounds have been detected internationally in illicit drugs and are the cause of increasing numbers of hospitalizations and overdoses. New analog…
  openalex Alison C. Leonard, Chase Lenert-Mondou, Rachel Chayer, Samuel D. Swift 等 2026-01-07 置信度 0.72 Computational biologyComputer scienceNanotechnologySynthetic biologyDrug discovery
• Nanotechnology in agri-food production: an overview
  Nanotechnology is one of the most important tools in modern agriculture, and agri-food nanotechnology is anticipated to become a driving economic force in the near future. Agri-food themes focus on sustainability and protection of agriculturally produced foods…
  openalex Bhupinder Singh Sekhon 2014-05-01 置信度 0.72 AgrochemicalApplications of nanotechnologyAgricultureFood processingBiotechnology
• What is Trust? A Multidisciplinary Review, Critique, and Synthesis
  Abstract Despite decades of interdisciplinary research on trust, the literature remains fragmented and balkanized with little consensus regarding its origins. This review documents how this came to be and attempts to offer a solution. Specifically, it evaluate…
  openalex Blaine G. Robbins 2016-10-01 置信度 0.72 ConceptualizationMultidisciplinary approachSociologyEpistemologyTrustworthiness
• Function, structure and therapeutic potential of complement C5a receptors
  Complement fragment (C)5a is a 74 residue pro-inflammatory polypeptide produced during activation of the complement cascade of serum proteins in response to foreign surfaces such as microorganisms and tissue damaged by physical or chemical injury. C5a binds to…
  openalex Peter N. Monk, A‐M Scola, Praveen K. Madala, David P. Fairlie 2007-07-02 置信度 0.72 C5a receptorReceptorComplement systemBiologyCell biology