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• Regulating microbial cell factories to resist ROS stress in chemical production.
  Escherichia coli (E. coli) cell factories are widely used to convert biomass-derived substrates into bulk and fine chemicals, including amino acids and organic acids. During high-level chemical production, however, product accumulation and metabolic burden can…
  pubmed Zhang L, Cheng Z, Yang J, Yang X 等 2026 Jul 24 置信度 0.82
• From Xenobiotic Exposure to Neuroinflammation: Mechanisms Linking Lipopolysaccharide Signaling to Depressive-like Behavior.
  Depression is increasingly recognized as a multifactorial disorder involving immune, metabolic, and neurobiological disturbances that extend beyond classical monoaminergic hypotheses. Among xenobiotic-based experimental approaches, lipopolysaccharide (LPS) has…
  pubmed Martins AMO, da Silva Soares MF, Oliveira LN, Barbosa NMMV 等 2026 Jul 10 置信度 0.82
• Albumin-Binding Domains in Therapeutic Protein Engineering: A Structural and Computational Perspective on Rational Design.
  Therapeutic proteins face a critical pharmacokinetic challenge: rapid clearance from circulation limits their clinical efficacy. Albumin-binding domains (ABDs) offer an elegant solution by enabling therapeutic proteins to "hitchhike" on serum albumin's favorab…
  pubmed Argyle MJ, Chipman DM, Woolley AC, Bundy BC 等 2026 Mar 置信度 0.82
• Waste to wealth: circular approaches for microbial pigment production.
  The increasing demand for natural and sustainable colorants has accelerated interest in microbial pigments as alternatives to synthetic dyes. Diverse microorganisms, including bacteria, fungi, yeasts, microalgae, and actinomycetes, produce pigments such as car…
  pubmed Devi M, Sarma AD, Deka S, Bhattacharyya R 等 2026 置信度 0.82
• Not just Rubisco: integrated strategies to overcome the biochemical limitations of C(3) photosynthesis.
  Photosynthesis is fundamental to global food security, but carbon assimilation efficiency in most C 3 crops remains significantly below its theoretical maximum. Three principal biochemical processes limit photosynthetic performance: ribulose-1,5-bisphosphate c…
  pubmed Patil SS, Muthan B, Sanjaya SA 2026 置信度 0.82
• CRISPRing through time: How cutting-edge technology is revolutionizing life sciences and medicine.
  Given the plethora of emerging technologies, none have truly captured the minds as CRISPR. From the groundbreaking research, the ultimate battle of the prizes and patents to a number of books, the science of CRISPR continues to be significant in the biomedical…
  pubmed Banik I, Coppé JP 2026 Sep 8 置信度 0.82
• Microbial-derived natural bionematicides in sustainable agriculture: Advances in biological control of Phytonematodes.
  Plant-parasitic nematodes (PPNs) are major hidden constraints in agriculture, causing significant yield losses across diverse cropping systems. Important genera such as Meloidogyne, Heterodera, Pratylenchus, and Rotylenchus exhibit complex host-parasite intera…
  pubmed Mani J, Chellappa S 2026 Aug 置信度 0.82
• Archaeal Diversity Sheds New Light on the Origin of the Eukaryotic Endomembrane System.
  The emergence of the endomembrane system marks a pivotal milestone in eukaryogenesis, transforming a primitive prokaryotic cell into a highly intracellular, compartmentalized eukaryotic cell. The molecular machinery underlying the endomembrane system has been …
  pubmed Lu Z, Zhang S, Song N, Feng X 等 2026 Jul 23 置信度 0.82
• Generation and characterization of a serum albumin-humanized mouse model and its utility for detection of albumin adduct formation in vivo.
  An albumin-humanized mouse model was generated via crossbreeding between albumin-transgenic and albumin-null mice and characterized. Immunoblot analyses confirmed that only human, but not mouse, albumin was expressed, and they revealed that the level of serum …
  pubmed Wu X, Han W, Yin L, Yang W 等 2026 Aug 置信度 0.82
• Metal-dependent regulated cell death: Molecular architecture and translational frontiers.
  Intracellular metal dyshomeostasis has emerged as a key regulator of specialized regulated cell death (RCD) programs, challenging classical views that regard necrosis as entirely accidental. This review systematically delineates the molecular architecture and …
  pubmed Hu H, Chen Z, Li Y, Peng J 等 2026 Jun 置信度 0.82
• SynBioGPT2: A dynamic reasoning framework enables high-fidelity design of microbial cell factories.
  The rational design of microbial cell factories is essential for sustainable biomanufacturing, yet the traditional Design-Build-Test-Learn (DBTL) cycle is bottlenecked by the highly non-linear and interconnected nature of biological systems. Although large lan…
  pubmed Mao Z, Du J, Guan J, Wang W 等 2026 Sep 置信度 0.82
• Modulation of TH17 cell activity by REV-ERB agonists: path toward novel treatments for canine meningoencephalitis of unknown origin.
  Meningoencephalitis of unknown origin (MUO) encompasses a heterogeneous group of non-infectious, presumed autoimmune, central nervous system diseases in dogs and remains a major therapeutic challenge in veterinary neurology. Mounting evidence from both experim…
  pubmed Bailey A, Gibson R, Griffett K 2026 置信度 0.82
• CAR-T cell signaling dynamics, rational design principles and artificial intelligence for next-generation chimeric antigen receptors.
  Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of hematologic malignancies, yet its efficacy in solid tumors and durability across broader application remain limited. A central challenge lies in how CAR signaling is initiated, amp…
  pubmed Liu X, Tong F, Zhang J, Gradishar W 等 2026 置信度 0.82
• Natural and synthetic chemicals acting as enhancers of bacterial pathogenic success within the human host.
  Like any other organism, bacteria are endowed with a myriad of receptors and signaling/regulatory mechanisms to detect chemical stimuli and develop appropriate responses. Whereas several of these chemicals - produced by bacteria themselves - display well-known…
  pubmed Escobar-Salom M, Barceló IM, Jordana-Lluch E, Sansó-Sastre J 等 2026 置信度 0.82
• Bacteriophage therapy beyond antibiotics: emerging innovations for infectious and non-infectious diseases.
  The advancement of synthetic biology and the rise of antimicrobial resistance have led to the development of bacteriophage therapy for more than antibacterial applications. This review focuses on applications to multidrug-resistant infections, biofilm diseases…
  pubmed Zhang B, Shu X, Masud AI, Karmakar J 等 2026 置信度 0.82
• Photothermal Catalysis: Material Construction, Performance Enhancement, and Application Progress.
  Photothermal catalysis is an innovative technology that integrates photocatalysis and thermochemistry to realize efficient fullspectrum solar energy utilization. It overcomes the drawbacks of conventional photocatalysis such as narrow spectral response and rap…
  pubmed Song D, Xia L, Xue D, Qiang L 等 2026 Jul 22 置信度 0.82
• Biotransformation-Driven Structural Remodeling of Natural Products by Ganoderma lucidum Fermentation: Mechanisms and Enhanced Bioactivities.
  Ganoderma lucidum fermentation (GLF) serves as a sustainable biotransformation platform that precisely modulates the chemical profiles and bioactivities of natural products through enzymatic hydrolysis, microbial metabolic remodeling, and substrate-microbe cro…
  pubmed Liu Y, Liu B, Zhu T, Chen N 等 2026 Jul 14 置信度 0.82
• Green synthesis revolution: harnessing biological factories for sustainable insect pheromone production in agriculture.
  Insect sex pheromones enable species-specific monitoring and mating disruption in integrated pest management, but wider adoption is limited by manufacturing complexity, particularly for molecules requiring stringent control of chain length, double-bond positio…
  pubmed Wang KX, Xia YH 2026 置信度 0.82
• Catalytic CO(2) hydrogenation toward net-zero fuels and chemicals.
  Heterogeneous catalytic CO 2 hydrogenation has emerged as a versatile route for converting captured CO 2 and renewable H 2 into fuels and chemicals, with relevance to carbon circularity, energy storage, and the progressive defossilisation of chemical manufactu…
  pubmed Yang C, Hu D, Yang X, Wang Z 等 2026 Aug 17 置信度 0.82
• Recent Advances in Nitric Oxide-Releasing Metallodrugs for Cancer Therapy.
  Nitric oxide (NO) is a highly versatile signaling molecule that plays dual, context-dependent roles in tumor biology: at low physiological concentrations, it promotes tumor progression, whereas at supraphysiological levels, it exerts potent cytotoxic effects. …
  pubmed Zeng J, Guo J, Chao H 2026 Jul 20 置信度 0.82
• Direct photoexcitation of borate complexes for radical generation: A platform from organic synthesis to chemical biology.
  Photochemical reactions enable access to reactive intermediates and bond-forming pathways that are often inaccessible under conventional thermal conditions. Among these, photoredox catalysis has become a powerful method for generating radicals, but it typicall…
  pubmed Ohmiya H 2026 置信度 0.82
• Evaluation of protease resistant synthetic antimicrobial peptides as a new approach methodology to mitigate bacterial growth in ex vivo human platelet concentrates.
  pubmed Jackson J, Chattagul S, Azodi N, Simmons N 等 2026 Jun 24 置信度 0.82
• De Novo Design of Protein Nanopores: From Minimal Peptides to AI-Driven Design.
  Protein nanopores offer a powerful platform for analytical applications by directly converting chemical properties into information-rich, single-molecule electrical readouts. However, engineering natural nanopores for sensing remains challenging due to the lim…
  pubmed Vorobieva AA, Samanta R, Thillo TV 2026 Aug 12 置信度 0.82
• From uncertainty to clarity: The evolution of Nuclear Medicine towards precision theranostics and AI-driven digital twins.
  Nuclear medicine has progressed from an exploratory discipline, historically constrained by limited spatial resolution and qualitative interpretation, into a rigorously quantitative clinical specialty. This evolution represents a systematic conversion of uncer…
  pubmed Giammarile F, Paez D, Brink A, Lobato EE 等 2026 Jan-Apr 置信度 0.82
• The chemistry and biology of securinega alkaloids.
  Securinega alkaloids have attracted immense attention from the phytochemical, synthetic, and pharmacological communities owing to their structural diversity and intriguing biological activities. Predominantly found in the genera Flueggea, Phyllanthus, Margarit…
  pubmed Lee C, Park S, Kim S, Han S 2026 置信度 0.82
• Bioinspired organic materials for seamless neurohybrid interfaces: from material design to living electronics.
  The brain architecture is multi-layered, with billions of neurons organized into intricate neural networks that communicate via synapses. Since synapse dysfunction is a main hallmark of neurological disorders, understanding the mechanisms underlying their fail…
  pubmed Stajković N, Manukânc A, Trilli M, Steinkühler J 等 2026 Jul 18 置信度 0.82
• γ-Class carbonic anhydrases: Ancient enzymes at the interface of early earth metabolism, microbial physiology, and modern biochemical innovation.
  γ-class carbonic anhydrases (γ-CAs) constitute one of the most ancient and structurally distinct CO₂-hydratase enzymes in prokaryotes, marked by metal flexibility and a catalytic mechanism compatible with anoxic, Fe 2+ -rich conditions infer…
  pubmed Di Costanzo LF, Capasso C, Supuran CT 2026 Jul 17 置信度 0.82
• Recurring principles of metabolic interactions in Enterococcus faecalis polymicrobial communities.
  Enterococcus faecalis is a human gut commensal and major opportunistic pathogen that is frequently found within polymicrobial communities at biofilm-associated infection sites, including the catheterized urinary tract, surgical and chronic wounds, the gut, and…
  pubmed Anderson CM, Kline KA 2026 Jul 17 置信度 0.82
• The critical role of artificial intelligence and bioinformatics in accelerating peptide-based vaccine discovery for tackling global infectious diseases.
  Peptide-based vaccines, enabled by bioinformatics and machine learning (ML), have emerged as one of the most promising approaches for rapid, safe, and cost-effective vaccine design against infectious diseases. Unlike conventional approaches that depend heavily…
  pubmed Tholo N, Markey G, Harrigan R, Pandey P 等 2026 Jul 3 置信度 0.82
• Bacteria mediated tumor therapy recent advances challenges and future perspectives.
  Bacteria, as simple unicellular microorganisms, can directly lyse tumor cells following intratumoral administration. Flagellin and cell wall components derived from bacteria can reshape the tumor microenvironment and activate host anti-tumor immune responses. …
  pubmed Mao W, Deng C 2026 Jul 17 置信度 0.82
• Stimuli-Responsive Synthetic Coacervates: Structural Design, Dynamics, and Functions.
  Liquid-liquid phase separation (LLPS), an interesting process in which a homogeneous solution demixes into solute-rich and solute-poor phases, serves as a ubiquitous mechanism for the formation of biomolecular condensates in living cells. Biomolecular condensa…
  pubmed Lian Z, Wang S, Wang H, Zhang Z 等 2026 Jul 29 置信度 0.82
• Multi-omics and synthetic microbial ecology for engineering climate-resilient phytobiomes in cold-arid agroecosystems: current advances and future perspectives.
  Extreme environmental stressors, including freezing temperatures, strong ultraviolet radiation, and nutrient scarcity, pose a serious threat to global food security in high-altitude cold-arid agroecosystems. Ecological stability depends on the phytobiome, whic…
  pubmed Kumar V, Ahmad F, Rai A, Kushwaha A 等 2026 置信度 0.82
• Engineered microbes to enable a circular economy for biodegradable plastics.
  Plastic pollution resulting from the continued dominance of fossil-derived polymers is a major global environmental challenge. Although biodegradable plastics, such as polylactic acid (PLA), polyhydroxyalkanoates (PHAs), polybutylene succinate (PBS), polybutyl…
  pubmed Madushanka D, Beard C, Kolitha BS, Dissanayake L 等 2026 置信度 0.82
• Cannabichromene (CBC): a comprehensive review of biosynthesis, pharmacology, therapeutic potential, and translational perspectives.
  Cannabis sativa L. produces a chemically diverse array of over 150 phytocannabinoids, of which cannabichromene (CBC) represents the fourth most abundant constituent in many chemovars, yet remains profoundly underexplored relative to its structural congeners de…
  pubmed Elbouzidi A, Baraich A, Haddou M, El Hachlafi N 等 2026 Jul 16 置信度 0.82
• Probiotics unveiled: bridging general health benefits to the era of precision medicine.
  Probiotics have long been recognized for their broad interests in regulating the immune system and promoting gut health. Recently, they have become a key component in the growing field of precision medicine. This review thoroughly examines the transition of pr…
  pubmed Ullah M, Rizwan M, Waheed MI, Alam MS 等 2026 Jul 17 置信度 0.82
• Overview and future potential in structural studies of bacteriophages by cryogenic electron microscopy.
  Recent advances in biological specimen preparation, electron optics, and image processing software have led to explosive growth in structural biology, in particular, in bacteriophage structural studies in situ. Bacteriophages are microscopical organisms and re…
  pubmed Sherman M, Orlova E 2026 置信度 0.82
• Exploration of multifunctional characteristics and regulatory mechanism of promoter G-quadruplexes.
  G-quadruplexes (G4s), a specialized nucleic acid secondary structure, have been found in recent years to be widely distributed in gene promoter regions. Growing evidence has highlighted the significance of G4 structures of promoter region in regulating various…
  pubmed Zhao Z, Zhang Y, Tian J, Su Y 等 2026 Jun 26 置信度 0.82
• Next-Generation Food Enzymology: From Metagenomic Discovery to AI-Driven Biocatalyst Design.
  Food enzymology is entering a new era driven by the convergence of metagenomics, artificial intelligence, and synthetic biology. While traditional food processes rely on a limited repertoire of established biocatalysts, metagenomic and multiomics approaches no…
  pubmed Schwartz M, Ladeira R, Neiers F, Nicolaï A 等 2026 Jul 29 置信度 0.82
• Metabolic engineering of Komagataella phaffii for enhanced production of heterologous proteins and small molecules: key strategies and future directions.
  Komagataella phaffii (syn. Pichia pastoris ) is an important host for the production of recombinant proteins and small molecules, often exhibiting superior performance compared to other heterologous hosts. With advancements in synthetic biology and computation…
  pubmed Xin J, Zhao L, Meng Y, Tian Z 等 2026 Aug 19 置信度 0.82
• Bottom-up reconstitution of model membrane systems: a mini-review.
  Bottom-up membrane reconstitution has become a powerful framework to investigate the physical principles governing membrane organization and function in highly controlled environments. Among the broad range of available model systems, supported lipid bilayers …
  pubmed Meena H, Wibowo K, De Franceschi N 2026 Jul 29 置信度 0.82
• Expanding the Horizon of CAR-T Cell Therapy: Present Obstacles and New Strategies for Future CARs in Solid Tumors.
  Chimeric antigen receptor (CAR)-T cells are synthetic receptors used for the recognition of specific antigens expressed by reprogrammed T cells for targeting tumors. CAR-T cell therapy has gained remarkable clinical success for the treatment of hematological m…
  pubmed Javed Q, Majeed S, Shahid A, Bano N 等 2026 Jul 10 置信度 0.82
• Tutorial: biomembranes in hybrid living bioelectronics.
  The integration of biological and artificial systems promises the effective coupling of living cells with electronic devices. However, to create biomimetic platforms capable of bridging biological with artificial systems, it is necessary to first enhance cell …
  pubmed Hattar A, Alhammadi J, Treiber J, Hoven D 等 2026 Jul 15 置信度 0.82
• Promiscuity of Cytochrome P450 Enzymes: Discovery Strategies, Mechanistic Insights, and Applications in Terpenoid Biosynthesis.
  Enzyme promiscuity drives metabolic diversity and evolutionary innovation. Among these, the cytochrome P450 (CYP) superfamily plays a central role in generating the immense structural complexity of terpenoid natural products. This review summarizes recent adva…
  pubmed Yuan W, Wang Y, Jing S, Wang J 等 2026 Jul 29 置信度 0.82
• Harnessing plant microbiomes to enhance crop resilience and restore war-affected soils in Ukraine.
  This review presents the current understanding of the rhizosphere microbiome and its potential application for the regeneration of damaged soils. The aim was to examine the issues of soil degradation associated with military actions and the latest developments…
  pubmed Shulga S, Tigunova O, Andriiash H, Yemets A 等 2026 置信度 0.82
• Multivalent DNA vaccines induce potent cellular responses and prolong BCG-mediated control of Mycobacterium tuberculosis.
  Mycobacterium tuberculosis (Mtb) remains a leading public health concern worldwide. While Bacillus Calmette-Guerin (BCG) vaccination is effective at protecting infants/children, efficacy wanes over time. Advancements in synthetic DNA technology have resulted i…
  pubmed Parzych EM, Bah MA, Tursi NJ, Gary EN 等 2026 Jul 14 置信度 0.82
• Therapeutic Potential of Kuwanon G: From Bioactivities to Network-Level Mechanisms.
  Natural products like the isoprenylated flavonoid Kuwanon G (KWG), isolated primarily from Morus alba , offer promising pleiotropic effects against multifactorial diseases, overcoming the limitations of conventional single-target synthetic drugs. This study ai…
  pubmed Aydemir E, Şimşek B, Acar A, Kilit AC 等 2026 Jul 1 置信度 0.82
• Recombinant Alphaherpesvirus Vectors in Veterinary Vaccinology: Platforms, Applications, and Translational Challenges.
  Animal infectious diseases impose severe economic burdens on livestock industries, threaten wildlife populations, and compromise food security. Although vaccination remains the cornerstone of disease prevention, conventional vaccine platforms are often constra…
  pubmed Mazloum A, Feoktistova SG, Ledyaeva V, Khulkhachiev G 等 2026 Jun 24 置信度 0.82
• Lentiviral single-cell MPRA of synthetic enhancers reveals motif affinity-based encoding of cell state specificity.
  Cell state-specific gene expression programs emerge from the interplay between cis-regulatory elements (CREs), such as enhancers, and transcription factors (TFs). Massively parallel reporter assays (MPRAs) have enabled large-scale dissection of CRE function, b…
  pubmed Rühle J, Frömel R, Martinez AB, Szu-Tu C 等 2026 Jul 14 置信度 0.82
• Random access elevates DNA from a storage medium to a storage system.
  DNA has emerged as a promising medium for next-generation information storage due to its ultra-high storage density, long-term stability, and low energy consumption. With the rapid growth of global digital data, DNA storage provides a potential alternative to …
  pubmed Yu H, Lu Z, Li D, Yuan Y 等 2026 Jul 14 置信度 0.82
• Molecular Regulation of Pyroptosis in Alzheimer's Disease: Linking Neuroinflammation, Cell Death, and Therapeutic Targeting.
  Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by profound cognitive decline, wherein chronic neuroinflammation plays a pivotal pathogenic role. Central to this inflammatory milieu is pyroptosis, a highly inflammatory form o…
  pubmed Hsu CY, Raval AD, Bainsal N, Kaur I 等 2026 Jul 14 置信度 0.82
• Generation of synthetic vascular organoids via orthogonal programming of human pluripotent stem cells.
  The development of functional human vasculature is essential for tissue engineering, disease modeling, and regenerative medicine. Conventional differentiation protocols of vascular lineages often exhibit lineage heterogeneity and limited control over cellular …
  pubmed Zhao Y, Sun M, Zhang K, Melero-Martin JM 等 2026 Jul 14 置信度 0.82
• Target discovery and drug design in the era of artificial intelligence.
  The identification of therapeutically actionable targets and the design of effective small-molecule modulators remain central challenges in drug discovery, particularly for complex diseases driven by dynamic, interconnected molecular networks. Recent advances …
  pubmed Fleming P, Ivanov AA 2026 Apr 23 置信度 0.82
• On the timing of eukaryotic origin.
  The emergence of eukaryotes marks a monumental juncture in the 4.6-billion-year evolutionary odyssey of our planet. Despite decades of research, the origin of eukaryotic life remains unresolved, with many of its nuances still veiled in the mists of time. While…
  pubmed Song N, Pang K, Feng X, Li M 2026 Jul 14 置信度 0.82
• De Novo Synthesis in Cancer Immunotherapy: Applications and Prospects.
  De novo protein design enables the creation of proteins with entirely novel structures and biological functions from scratch, offering a promising new paradigm for cancer immunotherapy. Emerging methodologies are integrating principles of rational design, incl…
  pubmed Jin Y, Wu Y, Luo J 2026 Jul 置信度 0.82
• The synthetic landscape of cereblon (CRBN) binders: from thalidomide to emerging chemotypes.
  Thalidomide, initially marketed as a sedative and anti-emetic, was withdrawn in the 1960s due to catastrophic teratogenic effects. Decades later, thalidomide was reconsidered as an anticancer agent, resulting in FDA approval against multiple myeloma. This succ…
  pubmed Rafael S, Sánchez-Zarzalejo C, Whelan R, Harris C 等 2026 Aug 17 置信度 0.82
• Recent advances in the biosynthesis of bacterial hybrid polyketide-non ribosomal peptide natural products.
  Polyketide synthases (PKSs) and non-ribosomal peptide synthetases (NRPSs) are multi-modular protein complexes responsible for the biosynthesis of numerous structurally diverse and biologically important natural products (NPs), including many clinically relevan…
  pubmed Das S, Shah DB, Mahanta N 2026 Sep 15 置信度 0.82
• Oncobiotics in urinary bladder cancer. A narrative review of living cancer therapeutics.
  Urinary bladder cancer (UBC) remains a major global health burden, with high recurrence rates and limited therapeutic options for patients who fail standard intravesical and systemic treatments. In recent years, Living Cancer Therapeutics (LCTs)-including bact…
  pubmed Abuhasanein S 2026 置信度 0.82
• Discovery of novel bio-resources from the hidden biodiversity of marine mangrove ecosystems.
  Marine mangrove wetlands are ecologically complex ecosystems that serve as rich reservoirs of biologically active compounds with significant biotechnological potential. This review synthesizes current knowledge on mangrove-associated microorganisms and biota, …
  pubmed Mathiyazhagan S, Balu B, Gunaseelan RJ, Piliyan R 等 2026 Jul 13 置信度 0.82
• CEP-CEPR1 Signalling in Cereal Crops: Integrating Nitrogen Demand, Root System Architecture, and Drought Resilience.
  Cereal crops collectively account for more than half of global human caloric intake, yet the molecular mechanisms governing their root systems under water and nitrogen limitation remain poorly understood relative to their agronomic importance. The C-terminally…
  pubmed Ali B, Khan Z, Imin N 2026 Jul 12 置信度 0.82
• Enhancing the Secretion Systems: Genetic Engineering of Super Bioagents for Effective Plant Disease Control.
  The escalating threat of plant diseases to global agriculture and food security necessitates innovative and sustainable control strategies. Conventional biological control agents (BCAs), while environmentally friendly, often suffer environmental challenges and…
  pubmed Asemoloye MD 2026 Jul 12 置信度 0.82
• Biocatalytic strategies for steroid synthesis: from side-chain remodeling to precision scaffold functionalization.
  Steroid synthesis is a cornerstone of pharmaceutical development, yet it remains hampered by the structural complexity of highly oxidized scaffolds and the presence of multiple stereogenic centers. Biocatalysis, characterized by unparalleled chemo-, regio-, an…
  pubmed Zheng M, Qu X 2026 Jul 28 置信度 0.82
• Emerging phototherapeutic roles of covalent organic frameworks in malignant cell ablation, wound healing, and pathogen control.
  Covalent organic frameworks (COFs) represent highly promising scaffolds for biomedical applications, notably in malignant cell ablation, infected wound healing, and antimicrobial phototherapies. Reticular design precisely controls the pore size, linkages, and …
  pubmed Paul J, Sangubotla R, Kim J 2026 Sep 置信度 0.82
• Intelligent detection technologies for microbes and disease biomarkers.
  Microbial communities play a critical role in human health, and their metabolic activities are directly implicated in the pathogenesis and progression of various diseases. Conventional detection methods for microbes and biomarkers, however, are hampered by lim…
  pubmed Liu S, Yang Y, Pan Y, Fan J 等 2026 Jul 11 置信度 0.82
• Advances in gene editing tools for four typical Gram-positive bacteria.
  Gram-positive bacteria serve as important chassis microorganisms in synthetic biology, industrial fermentation, and probiotic development. The rapid advancement of gene editing technologies has provided critical technical support for the iterative construction…
  pubmed Liang Z, Li Z, Li C, Zhao Y 等 2026 置信度 0.82
• De novo synthesis of large-scale metabolic pathways for natural products and their optimization strategies.
  Natural products constitute a vital source for drug discovery, yet extraction from producers is inefficient and chemical synthesis involves complex, low yield routes, limiting sustainable supply. Reconstructing large scale metabolic pathways (≥10 enzyma…
  pubmed Jiang JY, Dai JL, Chen HH, Jiang JG 等 2026 置信度 0.82
• Multifaceted nature of milk: potential source of parasites and a natural approach to parasite infection control.
  Milk, a vital dietary staple across cultures, exhibits a complex interplay of properties that extend beyond its nutritional value. This review explores the multifaceted nature of milk, highlighting its role as a potential carrier of parasitic pathogens, matrix…
  pubmed Awad DAB, Bayoumi SA, Hamad A 2026 Jul 10 置信度 0.82
• Engineering extracellular vesicle biogenesis for therapeutic gene delivery: emerging genetic programming strategies and translational prospects.
  Extracellular vesicles (EVs) have emerged as promising biological nanocarriers for gene therapy due to their intrinsic ability to transport nucleic acids, proteins, and lipids between cells. Advances in EV biology have revealed complex regulatory mechanisms go…
  pubmed Preetam S, Rath P, Al-Enazi NM, Sharaf AAM 等 2026 Jul 10 置信度 0.82
• Nucleoside Analog Natural Products: Over a Decade of Advances in Isolation, Biological Activity, and Synthesis.
  Nucleoside analogs represent one of the largest classes of anticancer and antiviral therapies, many of which have been directly or indirectly developed as a result of nucleoside natural product discovery. Over the past decade, renewed interest in this class ha…
  pubmed Raj M, Harada SY, Davison EK 2026 Jul 24 置信度 0.82
• Advances in phage therapy for Acinetobacter baumannii: mechanisms and applications.
  Acinetobacter baumannii poses a severe global health threat due to its extensive multi-drug resistance. This review explores the evolving role of phage therapy as a promising alternative against multi-drug resistant Acinetobacter baumannii infections. We revie…
  pubmed Cheng S, Zhou S, Wang X, Yu Z 等 2026 置信度 0.82
• Glycoengineering strategies for constructing defined Mucin O-glycans.
  Mucins are densely O-glycosylated proteins that establish mucosal barriers, mediate immune recognition, and serve as ligands for host lectins and microbes. However, mucin O-glycan structure-function relationships remain poorly defined due to inherent glycoform…
  pubmed Jaroentomeechai T, Phanchana M, Jaiboon K, Kruangkum T 2026 置信度 0.82
• Repurposing CRISPR-associated transposases for engineering microbiology.
  Clustered regularly interspaced short palindromic repeats (CRISPR) systems have revolutionized microbial genome editing. However, their reliance on DNA double-strand breaks (DSBs) and homologous recombination limits applications such as large DNA integration a…
  pubmed Chang T, Xin B, Li J, Irla M 等 2026 Jul 9 置信度 0.82
• Biological control of fungal spoilage in fruit: Mechanisms, microbial interactions, and implications for food quality.
  Fungal spoilage is a leading cause of postharvest losses in fruit, resulting in quality deterioration, economic losses, and food waste throughout the supply chain. Conventional control using synthetic fungicides faces increasing challenges from resistance deve…
  pubmed Liu J, Wang Z, Sui Y, Chen J 等 2026 Dec 置信度 0.82
• Rewiring cellular immunotherapy: From CAR evolution to circuit innovations across diseases.
  Chimeric antigen receptor (CAR)-based immunotherapy has evolved from early linear receptor designs into increasingly sophisticated biological signal processing systems. While conventional CAR-T cell therapies have achieved remarkable clinical success, particul…
  pubmed Chen J, Cui Y, Du K, Liu J 等 2026 Nov 置信度 0.82
• RNA activation in insects: From emerging evidence to molecular applications.
  RNA interference is commonly used as a reverse genetics tool to investigate gene function. In insects, this is achieved by introducing double-stranded RNA or synthetic short-interfering RNAs (siRNAs). However, RNA activation (RNAa) is less frequently utilised …
  pubmed Asgari S 2026 Jul 9 置信度 0.82
• Mechanobiological Design of Bioinspired Polymeric Scaffolds for Bone Regeneration.
  Bone regeneration presents a significant clinical challenge due to the complex interplay between biological processes and the local mechanical environment. While polymeric scaffolds are widely utilized for their tunable physicochemical properties, traditional …
  pubmed Lyu S, Wang J, Ren X, Li X 等 2026 Jul 9 置信度 0.82
• Next-Generation Cyanobacterial Biocontrol Agents for Crop Fungal Diseases: Molecular Mechanisms, Omics Insights, Applications, and Biosafety Considerations.
  Fungal diseases are major constraint to global crop production, causing substantial losses and increasing reliance on chemical fungicides. Cyanobacteria offers a sustainable alternative for disease managment due to their ability to produce antifungal metabolit…
  pubmed Ali S, Shahid M, Shafi Z, Almalki MA 2026 Jul 置信度 0.82
• Type 2 Inflammatory Diseases: The Crossroads of Immunity and Metabolism.
  The understanding of type 2 inflammatory diseases is undergoing a paradigm shift from "immune imbalance" toward "immune-metabolic crosstalk". Energy metabolism not only fuels immune responses but also fundamentally dictates the functional phenotypes of immune …
  pubmed Chen L, Pan ZX, Ma ZQ, Jin YX 等 2026 置信度 0.82
• Living Inorganic Nanomaterials: Design, Preparation, and Biomedical Applications.
  Living inorganic nanomaterials are defined as inorganic nanostructures that are integrated with living bacteria, cells, or biologically active cell-derived components. This unique integration addresses key limitations of traditional inorganic nanomaterials in …
  pubmed Ren J, Zheng B, Yang J, Rong H 等 2026 Aug 置信度 0.82
• From Negative Feedback to Integrated Control: Recombinase-Based Strategies for Mitigating Resource Competition.
  One of the key challenges in synthetic biology is the unintended interference between independently designed gene modules caused by resource competition within host cells. This interference disrupts circuit modularity and undermines the reliability of genetic …
  pubmed Zhang R, Zhang R, Tian XJ 2026 置信度 0.82
• Noncanonical caps, m(6)A, and Ψ RNA modifications in plant and animal development.
  RNA modifications constitute a dynamic layer of gene regulation during development. Among them, noncanonical caps, N 6 -methyladenosine (m 6 A), and pseudouridine (Ψ) represent three major classes of chemical marks. Noncanonical caps diversify the 5' end…
  pubmed Chen X, Hu H, Jia G, Yi C 等 2026 Jul 8 置信度 0.82
• Protein Turnover in Plants - Cost of Synthesis, Repair and Crop Engineering Opportunities.
  Protein lifespan is shaped by plant developmental stage and cellular requirements; both are fairly well understood processes. Beyond regulated degradation, chemical damage is another major cause of protein turnover, yet it is an understudied area in plant biol…
  pubmed Högerl AJI, Gnanamani S, Bathe U 2026 Jul 8 置信度 0.82
• Hydrogel degradation products as immunomodulatory cues in neural injury: mechanisms and implications for neural repair.
  Neural tissue engineering often uses hydrogels due to their tunable biophysical properties and biocompatibility. While much attention has been devoted to hydrogel mechanics and degradation kinetics, the role of hydrogel degradation byproducts in neural immune …
  pubmed Kishore J, Owen La Boucan FS, Abazari MF, Baldo KA 等 2026 Jul 29 置信度 0.82
• Fibroblasts: a diverse population of cells balancing homeostasis, wound healing, regeneration, inflammation, fibrosis, and cancer across organs.
  As the principal ECM-producing cell type, fibroblasts are essential regulators of tissue architecture and function in development, homeostasis, and disease. While their disease-promoting functions in fibrosis have long been the center of attention, it is incre…
  pubmed Yang X, Steffani M, Nadella S, Sheppard D 等 2026 Jul 8 置信度 0.82
• The evolution of the United States nucleic acid screening policies.
  In 2002, the chemical synthesis of poliovirus demonstrated the dual-use nature of gene synthesis technologies, and private entities initiated the steps towards preventing their misuse. Over the past several decades, nucleic acid sequence and customer screening…
  pubmed Epstein GL, Williams AE, Sharkey CM 2026 置信度 0.82
• Salt as a Master Regulator of Microbial Assembly and Metabolic Pathways in Fermented Fish: From Preservation to Flavor Innovation.
  Fermented fish constitutes a complex biotechnological system wherein fish substrates are transformed into value-added products via the synergistic metabolic interactions of microbial metabolism and enzymatic hydrolysis. Currently, the industry faces a critical…
  pubmed Chen XY, Huang XC, Chen Q, Yang YY 等 2026 Jul 置信度 0.82
• From tumor targeting to tumor accessibility: surface-engineered bacteria as precision living therapeutics for translational medicine.
  The concept of bacterial therapy dates back over a century to clinical observations that incidental infections could induce tumor regression. Recent advances in genetic engineering and synthetic biology have since transformed bacteria into versatile living the…
  pubmed Qiao L, Wu L, Xiao Y, Qiu J 等 2026 Jul 7 置信度 0.82
• Structural pharmacology of TRPA1 channel.
  Transient receptor potential ankyrin 1 (TRPA1) is a nonselective cation channel predominantly expressed in sensory neurons. Genetic associations of TRPA1 with human diseases, along with extensive experimental evidence, have fueled interest in targeting TRPA1 f…
  pubmed Cole BA, Chen H, Rohou A, Chen J 2026 Aug 置信度 0.82
• Leaf Rust in Rye: From Pathogen Biology to Host Defense and Resistance Breeding.
  Leaf rust (LR), caused by Puccinia recondita f. sp. secalis ( Prs ), is considered one of the most dangerous rye ( Secale cereale L.) diseases, causing yield losses exceeding 35%. This review summarizes all currently available data about this disease: pathogen…
  pubmed Rakoczy-Trojanowska M, Matuszkiewicz M, Szewińska J, Święcicka M 等 2026 Aug 25 置信度 0.82
• Exploring Neurological Disorder Therapeutics: The Progress and Future Prospects of Proteins and Peptides Derived from Blue Foods.
  Neurological illnesses continue to be a major global health challenge and require novel and safe therapeutic strategies. Blue foods like marine fish, algae, and invertebrates consist of many bioactive proteins/peptides that might provide multiple benefits for …
  pubmed Chaudhary M, Verma T, Singh RP, Sharma PK 等 2026 Jul 6 置信度 0.82
• Bioactive Peptides for Oral Diseases: Biomaterial-Assisted Therapeutics and Translational Applications.
  Dental caries, periodontitis, oral mucosal inflammation, peri-implant infections, and oral tissue defects remain major clinical burdens. Conventional treatments, including antimicrobials, antibiotics, anti-inflammatory agents, and regenerative materials, are f…
  pubmed Zhang L, Lin Y, Jia W, Xuan R 等 2026 Jul 20 置信度 0.82
• Systems engineering of engineered live biotherapeutics: A discovery-to-translation framework for streamlining microbiome therapeutic development.
  Despite the vast opportunities for therapeutic manipulation of the gut microbiome, recent late-stage clinical failures of engineered live biotherapeutic products (eLBPs) highlight critical knowledge gaps in ecological barriers and community dynamics. In this r…
  pubmed Hutchinson NT, Pang Z, Chimezie CI, Hamp B 等 2026 Sep 10 置信度 0.82
• Trichoderma-mediated biogenic synthesis of metal nanoparticles: Implications for soil health, plant resilience, and sustainable agroecosystems.
  The growing demand for sustainable agricultural practices has accelerated interest in eco-friendly alternatives to conventional agrochemicals. Among these, metal nanoparticles synthesized through biological routes have emerged as promising tools for crop prote…
  pubmed Ibrahim NA, Mehta H, Sulieman AME, Mir RH 等 2026 Oct 置信度 0.82
• Synthetic microbial communities: from theoretical exploration to applied innovation.
  Synthetic microbial communities (SynComs), which are artificially designed microbial communities, have shown significant potential for application in agriculture, environmental remediation, and medicine. The research surrounding SynComs is rooted in a comprehe…
  pubmed Wang T, Xiong L, Shen X, Sun J 等 2026 Jul 6 置信度 0.82
• SYNERGO-X: A STUDY ON BIOLOGICAL DEGRADATION OF MULTI-LAYERED PLASTICS...
  SYNERGO-X: A Synthetic Microbial Consortium Model for the Biological Degradation of Multi-Layered Plastics Author: Kushagra Saraswat Grade: 9th Standard Institution: Kendriya Vidyalaya CURAJ, Bandersindri, Rajasthan, India Subject: Environmental Biotechnology …
  datacite Saraswat, Kushagra 2026 置信度 0.66
• SYNERGO-X: A STUDY ON BIOLOGICAL DEGRADATION OF MULTI-LAYERED PLASTICS...
  SYNERGO-X: A Synthetic Microbial Consortium Model for the Biological Degradation of Multi-Layered Plastics Author: Kushagra Saraswat Grade: 9th Standard Institution: Kendriya Vidyalaya CURAJ, Bandersindri, Rajasthan, India Subject: Environmental Biotechnology …
  datacite Saraswat, Kushagra 2026 置信度 0.66
• Bioactive Compounds and Phytochemicals in Functional Foods: Mechanisms, Therapeutic Applications, and Research Frontiers
  This extensive technical review provides a deep dive into the role of bioactive compounds and dietary phytochemicals within functional foods, targeting researchers and drug development professionals. It systematically categorizes major plant-derived metabolite…
  datacite food chemical science 2026 置信度 0.66 bioactive compoundsphytochemicalsfunctional foodspolyphenolscarotenoids
• Bioactive Compounds and Phytochemicals in Functional Foods: Mechanisms, Therapeutic Applications, and Research Frontiers
  This extensive technical review provides a deep dive into the role of bioactive compounds and dietary phytochemicals within functional foods, targeting researchers and drug development professionals. It systematically categorizes major plant-derived metabolite…
  datacite food chemical science 2026 置信度 0.66 bioactive compoundsphytochemicalsfunctional foodspolyphenolscarotenoids
• Advances, challenges, and opportunities in engineering C5 and C6 sugar transporters in yeast for bio-based industrial biotechnology
  Harnessing biomass for bio-based industrial biotechnology is vital for addressing global energy needs and mitigating climate change. In this context, microorganisms are the cornerstone of biorefineries based on renewable materials, with applications in bioener…
  datacite João Gabriel Ribeiro Bueno, Ícaro Fier, Douglas Bruce Kell, Leandro Vieira dos Santos 2026 置信度 0.66 BiochemistrySpace ScienceMicrobiologyGeneticsPharmacology
• Advances, challenges, and opportunities in engineering C5 and C6 sugar transporters in yeast for bio-based industrial biotechnology
  Harnessing biomass for bio-based industrial biotechnology is vital for addressing global energy needs and mitigating climate change. In this context, microorganisms are the cornerstone of biorefineries based on renewable materials, with applications in bioener…
  datacite João Gabriel Ribeiro Bueno, Ícaro Fier, Douglas Bruce Kell, Leandro Vieira dos Santos 2026 置信度 0.66 BiochemistrySpace ScienceMicrobiologyGeneticsPharmacology
• Role of Synthetic and Natural FtsZ Inhibitors as Antibacterial Agents
  The escalating crisis of antimicrobial resistance (AMR), compounded by the dwindling antibiotic pipeline, necessitates the urgent identification of novel therapeutic targets. Filamenting temperature-sensitive mutant Z (FtsZ), a prokaryotic tubulin homologue an…
  datacite Arundhuti Mallik1,2, Sandeep CH. Reddy2, B. Sreelatha*1 2026 置信度 0.66 FtsZ; bacterial cell division; antimicrobial resistance; GTPase inhibitor; natural compounds; antibiotic targets.