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• Role of Synthetic and Natural FtsZ Inhibitors as Antibacterial Agents
  The escalating crisis of antimicrobial resistance (AMR), compounded by the dwindling antibiotic pipeline, necessitates the urgent identification of novel therapeutic targets. Filamenting temperature-sensitive mutant Z (FtsZ), a prokaryotic tubulin homologue an…
  datacite Arundhuti Mallik1,2, Sandeep CH. Reddy2, B. Sreelatha*1 2026 置信度 0.66 FtsZ; bacterial cell division; antimicrobial resistance; GTPase inhibitor; natural compounds; antibiotic targets.
• Advances in Medicinal Chemistry: Bridging Natural Products and Modern Drug Discovery
  ABSTRACT Medicinal chemistry has emerged as a dynamic discipline that integrates synthetic chemistry, pharmacology, computational modeling, and systems biology to accelerate drug discovery. Natural products remain indispensable due to their unparalleled struct…
  datacite Kandukuri Usha, Rani 2022 置信度 0.66
• Advances in Medicinal Chemistry: Bridging Natural Products and Modern Drug Discovery
  ABSTRACT Medicinal chemistry has emerged as a dynamic discipline that integrates synthetic chemistry, pharmacology, computational modeling, and systems biology to accelerate drug discovery. Natural products remain indispensable due to their unparalleled struct…
  datacite Kandukuri Usha, Rani 2022 置信度 0.66
• Bioprospecting of Microorganisms for Novel Enzymatic Degradation of Pollutants
  ABSTRACT Environmental pollution caused by persistent organic and inorganic contaminants has become a major global challenge, threatening ecosystem stability, biodiversity, and human health. Pollutants such as petroleum hydrocarbons, pesticides, dyes, pharmace…
  datacite Siva Ram Tejomoortula, Muni Vaishnavi 2026 置信度 0.66
• Bioprospecting of Microorganisms for Novel Enzymatic Degradation of Pollutants
  ABSTRACT Environmental pollution caused by persistent organic and inorganic contaminants has become a major global challenge, threatening ecosystem stability, biodiversity, and human health. Pollutants such as petroleum hydrocarbons, pesticides, dyes, pharmace…
  datacite Siva Ram Tejomoortula, Muni Vaishnavi 2026 置信度 0.66
• DYSBIOSIS AND HUMAN HEALTH, DRUG–MICROBIOME INTERACTIONS: AN EMERGING MICROBIOME THERAPEUTICS
  Dysbiosis refers to disruption of the normal microbial balance within the gastrointestinal tract, resulting in altered microbial diversity, impaired host–microbe interactions, and abnormal microbial metabolite production. The gut microbiota functions as a high…
  datacite 1*Dr. Virendra Kushwaha, 2Dr. Pooja Agrawal, 3Dr. Anuj Kumar, 4Dr. Sonali Chandra, 5Dr. Sarthak Goel, 6Dr. Mourriyan Elanchezhiyan 2026 置信度 0.66
• DYSBIOSIS AND HUMAN HEALTH, DRUG–MICROBIOME INTERACTIONS: AN EMERGING MICROBIOME THERAPEUTICS
  Dysbiosis refers to disruption of the normal microbial balance within the gastrointestinal tract, resulting in altered microbial diversity, impaired host–microbe interactions, and abnormal microbial metabolite production. The gut microbiota functions as a high…
  datacite 1*Dr. Virendra Kushwaha, 2Dr. Pooja Agrawal, 3Dr. Anuj Kumar, 4Dr. Sonali Chandra, 5Dr. Sarthak Goel, 6Dr. Mourriyan Elanchezhiyan 2026 置信度 0.66
• Marine-Derived Drugs and Their Applications in The Medical Field: A Comprehensive Review
  Marine ecosystems represent one of the most diverse and chemically rich environments on Earth, offering a vast reservoir of bioactive compounds with significant therapeutic potential. Marine organisms such as algae, sponges, mollusks, cyanobacteria, and fungi …
  datacite N. Thenmozhi*, V. Dharshini, Dr. N. Gnanasekar 2026 置信度 0.66 Marine drugs, marine pharmacology, bioactive compounds, anticancer, antimicrobial, drug discovery
• Marine-Derived Drugs and Their Applications in The Medical Field: A Comprehensive Review
  Marine ecosystems represent one of the most diverse and chemically rich environments on Earth, offering a vast reservoir of bioactive compounds with significant therapeutic potential. Marine organisms such as algae, sponges, mollusks, cyanobacteria, and fungi …
  datacite N. Thenmozhi*, V. Dharshini, Dr. N. Gnanasekar 2026 置信度 0.66 Marine drugs, marine pharmacology, bioactive compounds, anticancer, antimicrobial, drug discovery
• Fungal Innovations - Advancing Sustainable Materials, Genetics, and Applications for Industry
  Fungi play a crucial yet often unnoticed role in our lives and the health of our planet by breaking down organic matter through their diverse enzymes or eliminating environmental contamination, enhancing biomass pretreatment, and facilitating biofuel productio…
  datacite Hinneburg, Hannes, Gu, Shanna, Naseri, Gita, :unav 2025 置信度 0.66 bioprocessingcombinatorial optimizationfungal materialsustainabilitysynthetic biology
• Role of CRISPR-Cas9 Technology in Bioremediation
  The increasing global demand for agricultural productivity has led to extensive reliance on synthetic pesticides to manage pests such as insects, weeds, nematodes, and microbial pathogens. While effective, excessive pesticide usage has resulted in serious envi…
  datacite Gupta, Kashish, Meenakshi, Vidya, Tiwari, Madhurima, Masih, Neerja 2026 置信度 0.66 CRISPR-Cas9; Bioremediation; Gene Editing Technology
• Role of CRISPR-Cas9 Technology in Bioremediation
  The increasing global demand for agricultural productivity has led to extensive reliance on synthetic pesticides to manage pests such as insects, weeds, nematodes, and microbial pathogens. While effective, excessive pesticide usage has resulted in serious envi…
  datacite Gupta, Kashish, Meenakshi, Vidya, Tiwari, Madhurima, Masih, Neerja 2026 置信度 0.66 CRISPR-Cas9; Bioremediation; Gene Editing Technology
• Synthetic Biology and Global Deployment: Biosafety Considerations in Microbiology Research
  Abstract Synthetic biology has emerged as a transformative interdisciplinary field that integrates biology, engineering, and computational sciences to design and construct novel biological systems. Its rapid global deployment in areas such as medicine, agricul…
  datacite Patil, Priyanka Kande 2026 置信度 0.66 Keywords: Synthetic biology; Biosafety; Biosecurity; Microbial engineering; Biocontainment; Risk assessment
• Synthetic Biology and Global Deployment: Biosafety Considerations in Microbiology Research
  Abstract Synthetic biology has emerged as a transformative interdisciplinary field that integrates biology, engineering, and computational sciences to design and construct novel biological systems. Its rapid global deployment in areas such as medicine, agricul…
  datacite Patil, Priyanka Kande 2026 置信度 0.66 Keywords: Synthetic biology; Biosafety; Biosecurity; Microbial engineering; Biocontainment; Risk assessment
• Microbiome Engineering for Astronaut Health in Space: A Review
  Long-duration missions in space are characterized by exposure to microgravity, cosmic rays, isolation, disruption in circadian rhythm, and a controlled diet. These factors affect the human gut microbiome and induce microbiome dysbiosis, immunomodulation, metab…
  datacite Ansari, Arshiya Abul Kalam 2026 置信度 0.66
• Microbiome Engineering for Astronaut Health in Space: A Review
  Long-duration missions in space are characterized by exposure to microgravity, cosmic rays, isolation, disruption in circadian rhythm, and a controlled diet. These factors affect the human gut microbiome and induce microbiome dysbiosis, immunomodulation, metab…
  datacite Ansari, Arshiya Abul Kalam 2026 置信度 0.66
• DNA Sequencing and Genetic Engineering: Technologies, Applications, and Future Perspectives
  This academic report was prepared as part of my degree programme. It provides a comprehensive review of DNA sequencing technologies, including Sanger sequencing, next-generation sequencing (NGS), and third-generation sequencing. The report examines genetic eng…
  datacite Sri Wijebandara, Rishmi Ayodhya 2025 置信度 0.66 DNA Sequencing Sanger Sequencing Next-Generation Sequencing (NGS) Third-Generation Sequencing Genetic Engineering Gene Cloning CRISPR Synthetic Biology Bioinformatics Molecular Biotechnology Gene Therapy Precision Medicine
• DNA Sequencing and Genetic Engineering: Technologies, Applications, and Future Perspectives
  This academic report was prepared as part of my degree programme. It provides a comprehensive review of DNA sequencing technologies, including Sanger sequencing, next-generation sequencing (NGS), and third-generation sequencing. The report examines genetic eng…
  datacite Sri Wijebandara, Rishmi Ayodhya 2025 置信度 0.66 DNA Sequencing Sanger Sequencing Next-Generation Sequencing (NGS) Third-Generation Sequencing Genetic Engineering Gene Cloning CRISPR Synthetic Biology Bioinformatics Molecular Biotechnology Gene Therapy Precision Medicine
• Synthetic Biology: Bottom-Up Assembly of Molecular Systems.
  The bottom-up assembly of biological and chemical components opens exciting opportunities to engineer artificial vesicular systems for applications with previously unmet requirements. The modular combination of scaffolds and functional building blocks enables …
  datacite Hirschi, Stephan, Ward, Thomas R, Meier, Wolfgang P, Müller, Daniel J 等 2022 置信度 0.66
• Clinical Perspectives of Pulp Regeneration.
  INTRODUCTION A sound and vital pulp is an essential prerequisite for long-term tooth survival and preservation. However, current endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by a synthetic bioma…
  datacite Schmalz, Gottfried Hans, Widbiller, Matthias, Galler, Kerstin M 2020 置信度 0.66 Dental pulp necrosis pulpectomy pulpitis pulpotomy regenerative endodontics root canal obturation
• CRISPRing KRAS: A Winding Road with a Bright Future in Basic and Translational Cancer Research.
  Once considered "undruggable" due to the strong affinity of RAS proteins for GTP and the structural lack of a hydrophobic "pocket" for drug binding, the development of proprietary therapies for KRAS-mutant tumors has long been a challenging area of research. C…
  datacite Gong, Xian, Du, Jianting, Peng, Ren-Wang, Chen, Chun 等 2024 置信度 0.66 CRISPR KRAS gene editing resistance synthetic lethal
• RECENT ADVANCES AND EMERGING APPLICATIONS IN NANOSCIENCE
  Nanoscience has emerged as one of the most transformative interdisciplinary fields, integrating principles of chemistry, physics, biology, materials science, and engineering to manipulate matter at the nanoscale (1–100nm). The production of innovative nanomate…
  datacite Amash Vijayalakshmi 2026 置信度 0.66 Nanomaterials, nanocarriers, nanozymes, LNP (lipidnanoparticles).
• RECENT ADVANCES AND EMERGING APPLICATIONS IN NANOSCIENCE
  Nanoscience has emerged as one of the most transformative interdisciplinary fields, integrating principles of chemistry, physics, biology, materials science, and engineering to manipulate matter at the nanoscale (1–100nm). The production of innovative nanomate…
  datacite Amash Vijayalakshmi 2026 置信度 0.66 Nanomaterials, nanocarriers, nanozymes, LNP (lipidnanoparticles).
• DRT7-Mediated Protein-Templated DNA Synthesis: A New Paradigm Beyond Classical Reverse Transcription
  Reverse transcriptases (RTs) have traditionally been recognized as enzymes that catalyze the synthesis of complementary DNA (cDNA) from RNA templates, representing a fundamental process in retroviral replication, mobile genetic elements, and molecular biotechn…
  datacite Ram Patil*1, Nikhil Patil2, Bhagyashri Patil3, Mahesh Patil4, Prashant Wagh2, Suresh Pawara5, Akash Mali6 2026 置信度 0.66 DRT7; Reverse transcriptase; Protein-templated DNA synthesis; Primase–polymerase; RT–PrimPol coupling; Anti-phage defense; Duplex-like poly(A/T) DNA; Bacterial immunity; Synthetic biology; DNA polymerase evolution.
• DRT7-Mediated Protein-Templated DNA Synthesis: A New Paradigm Beyond Classical Reverse Transcription
  Reverse transcriptases (RTs) have traditionally been recognized as enzymes that catalyze the synthesis of complementary DNA (cDNA) from RNA templates, representing a fundamental process in retroviral replication, mobile genetic elements, and molecular biotechn…
  datacite Ram Patil*1, Nikhil Patil2, Bhagyashri Patil3, Mahesh Patil4, Prashant Wagh2, Suresh Pawara5, Akash Mali6 2026 置信度 0.66 DRT7; Reverse transcriptase; Protein-templated DNA synthesis; Primase–polymerase; RT–PrimPol coupling; Anti-phage defense; Duplex-like poly(A/T) DNA; Bacterial immunity; Synthetic biology; DNA polymerase evolution.
• Advances in noncanonical amino acid incorporation for enzyme engineering applications
  Incorporation of noncanonical amino acids (ncAAs) via genetic code expansion (GCE) opens up new possibilities for chemical biology. The technology has led to the development of novel xenobiotic enzymes with tailored properties which can serve as entry points i…
  datacite Giger, Sandro, Buller, Rebecca 2023 置信度 0.66 Chemical synthesisEnzyme engineeringEnzyme mechanismGenetic code expansionNew-to-nature enzyme
• A dual Translational framework for addressing food and water contamination in India through the Science–Ayurveda bridge and Italian–Indian Strategic Cooperation
  Description This document presents an innovative dual-tier translational research architecture intended to bridge the gap between contemporary molecular Toxicology and the adaptive Physiopathological frameworks of classical Ayurveda. The framework addresses th…
  datacite Luongo, Valentina 2026 置信度 0.66
• A dual Translational framework for addressing food and water contamination in India through the Science–Ayurveda bridge and Italian–Indian Strategic Cooperation
  Description This document presents an innovative dual-tier translational research architecture intended to bridge the gap between contemporary molecular Toxicology and the adaptive Physiopathological frameworks of classical Ayurveda. The framework addresses th…
  datacite Luongo, Valentina 2026 置信度 0.66
• Recent advances in the development of small molecule STK33 inhibitors
  The serine/threonine kinase 33 (STK33) has attracted attention in recent years as a synthetic-lethal partner of oncogenic KRAS, thereby representing a potential indirect route to target KRAS-driven cancers. Initially, RNAi screens suggested that STK33 inhibiti…
  datacite Dipti B. Upadhyay, Mehul P. Parmar, Hitendra M. Patel 2026 置信度 0.66 BiochemistryMolecular BiologyPharmacologyChemical Sciences not elsewhere classifiedBiological Sciences not elsewhere classified
• Recent advances in the development of small molecule STK33 inhibitors
  The serine/threonine kinase 33 (STK33) has attracted attention in recent years as a synthetic-lethal partner of oncogenic KRAS, thereby representing a potential indirect route to target KRAS-driven cancers. Initially, RNAi screens suggested that STK33 inhibiti…
  datacite Dipti B. Upadhyay, Mehul P. Parmar, Hitendra M. Patel 2026 置信度 0.66 BiochemistryMolecular BiologyPharmacologyChemical Sciences not elsewhere classifiedBiological Sciences not elsewhere classified
• A study of the development of DDT resistant strains of the house fly Musca domestica L. and the laboratory mouse Mus musculus domesticus L.
  The growing use of synthetic chemicals to combat insects of economic importance to man has led to the discovery and wide recognition of changes in the nature of insect populations and of subsequent control failures. Changes which result in inadequate control w…
  datacite Ozburn, George. W. 1963 置信度 0.66 Entomology
• A study of transcriptional regulatory network reconstruction
  Les protéines sont des molécules fonctionnelles dans une cellule avec des rôles importants dans la structure, la fonction et la régulation de différents processus biologiques. De plus, les gènes codants pour les protéines contiennent les informations nécessair…
  datacite Su, Chen 2022 置信度 0.66 Electrical and Computer Engineering
• Synzymes 2.0: Engineering catalytic function with artificial intelligence and advanced materials
  The evolution of synthetic enzymes (synzymes) from simple biomimetic catalysts to sophisticated engineered systems represents a paradigm shift in biocatalysis. This comprehensive review provides a critical analysis of the current synzyme landscape, examining t…
  datacite Shah Faisal Mohammad, Fawad Ali, Shynara Mamirkulova 2026 置信度 0.66 Space ScienceMedicineBiotechnologyEnvironmental Sciences not elsewhere classifiedBiological Sciences not elsewhere classified
• Synzymes 2.0: Engineering catalytic function with artificial intelligence and advanced materials
  The evolution of synthetic enzymes (synzymes) from simple biomimetic catalysts to sophisticated engineered systems represents a paradigm shift in biocatalysis. This comprehensive review provides a critical analysis of the current synzyme landscape, examining t…
  datacite Shah Faisal Mohammad, Fawad Ali, Shynara Mamirkulova 2026 置信度 0.66 Space ScienceMedicineBiotechnologyEnvironmental Sciences not elsewhere classifiedBiological Sciences not elsewhere classified
• Synthetic Biology: A Scientific Review of Current Developments Synthetic Biology: A Scientific Review of Current Developments and Future Perspectives
  The field of synthetic biology combines principles from biology, engineering, and computer science to create novel biological systems with specific functions. It has made significant advances in engineering genetic circuits, creating biosensors and bioproducti…
  datacite Shobha Malaviya, Dibyaranjan Samal, Meesala Krishna Murthy, Pratima Khandayataray 2023 置信度 0.66
• Innovative Methodologies In Venom Research: Unveiling Complexities And Therapeutic Potentials: A Review
  Abstract: Venom is composed of complex biochemical molecules, have long intrigued scientists for their potential therapeutic applications. Recent advancements in venom research, driven by innovative methodologies such as high-throughput proteomics, genomics, a…
  datacite Rohan, Kamble, Pol Suvarna 2025 置信度 0.66 Keywords: Venomics, toxin, Snake venom, Peptides, Proteomics
• Generative Artificial Intelligence in Bioinformatics: A Systematic Review of Models, Applications, and Methodological Advances
  Generative artificial intelligence (GenAI) is transforming bioinformatics by advancing genomics, proteomics, transcriptomics, structural biology, and drug discovery. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses framework, th…
  datacite Karim, Wasimul, Alvi, Riasad, Zaman, Sayeem Been, Abian, Arefin Ittesafun 等 2025 置信度 0.66 Computation and Language (cs.CL)Artificial Intelligence (cs.AI)FOS: Computer and information sciences
• SciCoQA: Quality Assurance for Scientific Paper--Code Alignment
  Discrepancies between scientific papers and their code undermine reproducibility, a concern that grows as automated research agents scale scientific output beyond human review capacity. Whether LLMs can reliably detect such discrepancies has not been systemati…
  datacite Association for Computational Linguistics 2026, Baumgärtner, Tim, Gurevych, Iryna 2026 置信度 0.66 Computational LinguisticsArtificial IntelligenceSemantic EvaluationNatural Language Processing
• Neural Array Projection Oscillation Tomography: A Ten-Stage Developmental Genealogy and Falsifiable Reconstruction Framework
  Neural Array Projection Oscillation Tomography (NAPOT) proposes that distributed neural populations receive partial measurements, transform them through state-dependent temporal structure, project consequences, and recurrently update an action-relevant estimat…
  datacite Blumberg, Micah 2026 置信度 0.66 preprintSelf-Aware Networks
• Neural Array Projection Oscillation Tomography: A Ten-Stage Developmental Genealogy and Falsifiable Reconstruction Framework
  Neural Array Projection Oscillation Tomography (NAPOT) proposes that distributed neural populations receive partial measurements, transform them through state-dependent temporal structure, project consequences, and recurrently update an action-relevant estimat…
  datacite Blumberg, Micah 2026 置信度 0.66 preprintSelf-Aware Networks
• Teoría General de las Arquitecturas Biofotónicas Hiperorganizadoras
  Teoría General de las Arquitecturas Biofotónicas Hiperorganizadoras La Ingeniería de Organismos Ecosistémicos Arquitectónicos como nueva disciplina de integración física, biológica e ingenieril La Nueva Frontera Científica del Arbor Vitae Omega Ω: hacia una Te…
  datacite Ulaneo, Fermin 2026 置信度 0.66
• Teoría General de las Arquitecturas Biofotónicas Hiperorganizadoras
  Teoría General de las Arquitecturas Biofotónicas Hiperorganizadoras La Ingeniería de Organismos Ecosistémicos Arquitectónicos como nueva disciplina de integración física, biológica e ingenieril La Nueva Frontera Científica del Arbor Vitae Omega Ω: hacia una Te…
  datacite Ulaneo, Fermin 2026 置信度 0.66
• Aero Shadow
  Based on the document, the Dark Wind Heavy hypersonic upgrade outperforms existing missiles like Russia's 3M22 Zircon by utilizing a Laser-Induced Directed Energy Air Spike (DEAS) to bypass the standard atmospheric drag and thermal limits that restrict current…
  datacite lee, francis 2026 置信度 0.66
• Turbocharging fundamental science translation through controlled environment agriculture.
  Controlled environment agriculture (CEA) provides unprecedented opportunities to accelerate the translation of plant science breakthroughs into agricultural impact. By precisely controlling growth conditions, CEA enables the reliable and tightly regulated depl…
  datacite Gill, Alison R, Miller, Troy K, Wijeweera, Samalka, Herrero, Eva 等 2026 置信度 0.66 CEAcontrolled environment agricultureplant geneticsplant metabolismplant physiology
• The Quantum Mechanics of Melanin Protecting the Retina... Demonstration of Chemical Electron Excitation
  A paper published in the international journal Eye (Springer Nature) highlights the quantum chemical phenomenon of "chemiexcitation," where melanin in retinal pigment epithelium (RPE) cells excites electrons to high-energy states purely through molecular inter…
  datacite inquantio 2026 置信度 0.66 quantum biology
• The Quantum Mechanics of Melanin Protecting the Retina... Demonstration of Chemical Electron Excitation
  A paper published in the international journal Eye (Springer Nature) highlights the quantum chemical phenomenon of "chemiexcitation," where melanin in retinal pigment epithelium (RPE) cells excites electrons to high-energy states purely through molecular inter…
  datacite inquantio 2026 置信度 0.66 quantum biology
• How have the public been engaged with biotechnology and what are the outcomes?
  This is a scoping review protocol for work package six of the PhotoBoost project. It aims to provide an initial understanding of how different publics have been engaged with biotechnology and the themes that emerge from such engagement.
  datacite Jonathan Menary, Sebastian Fuller 2022 置信度 0.66 Life SciencesBiotechnologyPublic EngagementScoping ReviewSynthetic Biology
• Structured PREreview of "Live-cell imaging of enhancer-promoter dynamics reveals transient contact-driven gene activation"
  This Zenodo record is a permanently preserved version of a Structured PREreview. You can view the complete PREreview at https://prereview.org/reviews/21246220. Does the introduction explain the objective of the research presented in the preprint? Yes Although …
  datacite John Patrick Flores 2026 置信度 0.66 Structured PREreview
• Structured PREreview of "Live-cell imaging of enhancer-promoter dynamics reveals transient contact-driven gene activation"
  This Zenodo record is a permanently preserved version of a Structured PREreview. You can view the complete PREreview at https://prereview.org/reviews/21246220. Does the introduction explain the objective of the research presented in the preprint? Yes Although …
  datacite John Patrick Flores 2026 置信度 0.66 Structured PREreview
• Cotranslational Assembly of Oligomeric Proteins
  The assembly of newly synthesized proteins into functionally active oligomers has long been regarded as a posttranslational process driven by random collision of subunits. However, growing evidence indicates that, for many proteins, assembly occurs cotranslati…
  datacite Santos, Jaime, Tans, Sander J., Ban, Nenad, Kramer, Günter 等 2026 置信度 0.66 Cotranslational assemblyProtein complexTranslationRibosomesNascent chain
• Development of genetically engineered live biotherapeutic products and biocontainment systems
  Since the earliest human societies, microorganisms have been harnessed for their probiotic properties. In the 20th century, advances in DNA technology enabled the artificial enhancement of microbial traits, leading to the development of organisms with improved…
  datacite Maneira, Carla 2026 置信度 0.66 Synthetische BiologieGentechnologie570
• Timing of Orthodontic Tooth Movement in Bone Defects Repaired with Synthetic Scaffolds: A Scoping Review of Animal Studies
  The optimal timing of orthodontic tooth movement (OTM) could allow earlier tooth movements across alveolar bone defects while minimizing the adverse effects. Despite the tremendous amount of published articles focusing on novel biomaterials, the graft stabilit…
  datacite Milton Hongli Tsai, Rohaya Megat Abdul Wahab, Farinawati Yazid 2021 置信度 0.66 Dental MaterialsMedicine and Health SciencesOral Biology and Oral PathologyOrthodontics and OrthodontologyDentistry
• Biotechnology in Space Research: An Extensive Analysis
  Long-term human habitation plans that reach the Moon, Mars, and even beyond are quickly replacing short, robotic space missions. The use of biological systems and creatures to create goods and technologies or biotechnology is essential to tackling the main iss…
  datacite Archana Tajane, Rimsha Khan, Rucha Dasari, Mahvish Khan 2026 置信度 0.66 Keywords: Space, Biotechnology, astrobiology, synthetic biology, genetic engineering
• Biotechnology in Space Research: An Extensive Analysis
  Long-term human habitation plans that reach the Moon, Mars, and even beyond are quickly replacing short, robotic space missions. The use of biological systems and creatures to create goods and technologies or biotechnology is essential to tackling the main iss…
  datacite Archana Tajane, Rimsha Khan, Rucha Dasari, Mahvish Khan 2026 置信度 0.66 Keywords: Space, Biotechnology, astrobiology, synthetic biology, genetic engineering
• One Token Across Twenty Orders of Magnitude: Where a Single-Token Class-Discriminant Codebook Works, Where It Does Not, and When to Add a Co-Channel
  Description This record accompanies a manuscript that asks one question at extreme breadth: can a single compact, on-device token — one window of a signal reduced to a single ~6-9-bit class-discriminant codebook index — carry a decision across sensing modaliti…
  datacite Ferlic, Randolph James, Ferlic, Kimberly Kate 2026 置信度 0.66 class-discriminant codebookvector quantizationon-device inferenceedge AIcross-scale sensing
• One Token Across Twenty Orders of Magnitude: Where a Single-Token Class-Discriminant Codebook Works, Where It Does Not, and When to Add a Co-Channel
  Description This record accompanies a manuscript that asks one question at extreme breadth: can a single compact, on-device token — one window of a signal reduced to a single ~6-9-bit class-discriminant codebook index — carry a decision across sensing modaliti…
  datacite Ferlic, Randolph James, Ferlic, Kimberly Kate 2026 置信度 0.66 class-discriminant codebookvector quantizationon-device inferenceedge AIcross-scale sensing
• Genomic and experimental insights into the ecology and evolution of transferable genetic elements
  Bacteria have dynamic genomes that allow them to adapt and survive almost anywhere on Earth. This genetic flexibility is facilitated by mobile DNA elements, which can transfer within or between genomes independently of cell lineages and drive bacterial evoluti…
  datacite Lerminiaux, Nicole Anne 2022 置信度 0.66
• A Model Of Tlr4 Signaling And Tolerance Using A Qualitative, Particle-Event-Based Method: Introduction Of Spatially Configured Stochastic Reaction Chambers (SCRSC)
  Introduction: There have been great advances in the examination and characterization of intracellular signaling and synthetic pathways. However, these pathways are generally represented using static diagrams when in reality they exist with considerable dynamic…
  datacite Gary An 2019 置信度 0.66
• Global Disease Research & Automated Therapeutics
  Author: Luigi Usai Place: Quartucciu (CA), Italy Time: 28/06/2026, 12:01 ORCID: https://orcid.org/0009-0003-3001-717X Medicina dei Sistemi e Farmacologia di Rete (Network Pharmacology). Il documento citato si inserisce nell'attuale frontiera della convergenza …
  datacite Usai, Luigi 2026 置信度 0.66 Luigi UsaiUsai LuigiUsaiIpergrafo di UsaiUsai's Hypergraph
• Aero Shadow
  Based on the document, the Dark Wind Heavy hypersonic upgrade outperforms existing missiles like Russia's 3M22 Zircon by utilizing a Laser-Induced Directed Energy Air Spike (DEAS) to bypass the standard atmospheric drag and thermal limits that restrict current…
  datacite lee, francis 2026 置信度 0.66
• Reclaimed water for irrigation and crop health: Decoding antibiotic accumulation and metabolic resilience
  The escalating global water scarcity and increasing food demand have accelerated the use of reclaimed water for agricultural irrigation, particularly in arid and semi-arid regions. However, the pervasive presence of antibiotic residues in reclaimed water, orig…
  datacite Rui Zhao, Chengyun Zhou, Shouvik Saha, Byong-Hun Jeon 等 2026 置信度 0.66 Space ScienceMedicineEnvironmental Sciences not elsewhere classifiedEcologyScience Policy
• Reclaimed water for irrigation and crop health: Decoding antibiotic accumulation and metabolic resilience
  The escalating global water scarcity and increasing food demand have accelerated the use of reclaimed water for agricultural irrigation, particularly in arid and semi-arid regions. However, the pervasive presence of antibiotic residues in reclaimed water, orig…
  datacite Rui Zhao, Chengyun Zhou, Shouvik Saha, Byong-Hun Jeon 等 2026 置信度 0.66 Space ScienceMedicineEnvironmental Sciences not elsewhere classifiedEcologyScience Policy
• Systematic review of Leber's hereditary optic neuropathy - Clinical diagnosis, genetics overview and current concepts of treatment.
  Leber hereditary optic neuropathy (LHON) is the most common mitochondrial disorder, typically causing substantial, often permanent, central vision loss in young adults. It manifests as a subacute optic neuropathy, frequently progressing sequentially in both ey…
  pubmed Ambika S, Srilekha S 2026 Aug 1 置信度 0.82
• Exploring halophilic microorganisms for novel antimicrobial discovery: molecular mechanisms and computational approaches.
  The rapid rise in antibiotic resistance, which causes more than 700,000 deaths worldwide each year, has intensified the search for alternative antimicrobial sources to combat multidrug-resistant (MDR) pathogens. Halophilic microorganisms inhabiting hypersaline…
  pubmed Bhowmick P, Kumar P, Panjabi S, Dhiman S 2026 Jul 31 置信度 0.82
• Post-transcriptional regulation of allele-specific expression.
  Allele-specific expression (ASE) serves as a unique readout for understanding how genetic and epigenetic variations fine-tune gene regulation in diploid organisms. While allelic transcriptional control mediated by cis-elements and epigenetic marks has been ext…
  pubmed Zhang Y, Wang CL, Wu L, Luo GZ 2026 Jul 30 置信度 0.82
• Exploiting the weak link: Ataxia-Telangiectasia Mutated dysfunction in oesophagogastric tumours.
  ATM (ataxia-telangiectasia mutated) is a central regulator of the DNA damage response, coordinating double-strand break repair, checkpoint control, and cell fate decisions. Its disruption drives genomic instability and has been implicated across multiple tumou…
  pubmed Trybala Z, Costella G, Bednarova K, Arcimowicz Ł 等 2026 Jul 30 置信度 0.82
• Rubisco limits plant breeding: can biodiversity unlock it?
  Photosynthesis has been underestimated as a breeding target. A workflow that identifies or engineers superior Rubisco variants and introduces them into crops is urgently needed. Photosynthesis is the foundation of life on Earth, yet it remains inefficient in c…
  pubmed Luna-Rodriguez P, Lee C, Monroe G 2026 Jul 30 置信度 0.82
• Recent Advances in Fluorescent Probes for Imaging Enzyme Activity in NETosis.
  Neutrophil extracellular traps (NETs) are web-like structures of DNA released by neutrophils during a specialized form of cell death called NETosis. Originally described as a mechanism of pathogen neutralization, NETs have since been implicated in a growing nu…
  pubmed Ramos Cáceres E, Hollander MJ, Bonger KM 2026 Aug 14 置信度 0.82
• Microbial remediation of recalcitrant pollutants in soil and geo-environmental engineering systems.
  Polycyclic aromatic hydrocarbons (PAHs), petroleum hydrocarbons, chlorinated compounds, pesticides, pharmaceuticals, per- and polyfluoroalkyl substances and heavy metals are all examples of pollutants that are more difficult to degrade in the environment, are …
  pubmed S A, Priya AK 2026 置信度 0.82
• Succinate-mediated metabolic alterations and signaling in RA: mechanisms and therapeutic implications.
  Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation. Recent studies have revealed that immune metabolites, particularly succinate, play a critical role in its pathogenesis. In this review, we systematical…
  pubmed Fan Y, Wang N, Zhao C, Zhang Z 2026 置信度 0.82
• Bridging the validation gap: organoids as functional decision systems in drug repurposing.
  Drug repurposing offers a faster and less costly route to therapeutic development, yet its translational success remains constrained by a critical scientific and evidentiary gap: the absence of human-relevant intermediate validation systems capable of converti…
  pubmed Gulisano M 2026 Sep 置信度 0.82
• In vivo delivery strategies for therapeutic CRISPR genome editing.
  CRISPR-based genome and epigenome editing technologies have rapidly evolved from programmable nucleases into a diverse therapeutic toolbox encompassing conventional CRISPR systems, base editing, prime editing, RNA targeting, and epigenetic modulation. While ea…
  pubmed Martin L, Bohinc J, Recchia A, Gritti S 等 2026 置信度 0.82
• Anticancer natural products from the Middle East and North Africa: biodiversity, mechanisms, and translational challenges.
  Cancer remains one of the leading causes of morbidity and mortality worldwide, imposing substantial clinical, societal, and economic burdens. Despite major advances in surgical oncology, systemic chemotherapy, radiation therapy, molecularly targeted therapeuti…
  pubmed Hamiyeh R, Salhab Z, Bahmad HF, Abou Fayad AG 等 2026 置信度 0.82
• Evaluating AI-assisted customer verification for synthetic nucleic acid screening.
  Legitimacy screening, the process of verifying the identity and purpose of customers ordering synthetic nucleic acids, is a primary safeguard against the misuse of synthetic biology. However, the associated costs discourage the adoption of screening practices.…
  pubmed Acelas A, Palya H, Flyangolts K, Fady PE 等 2026 置信度 0.82
• Endophytic Entomopathogenic Fungi Shape Herbivore Behavior and Plant-Insect Interactions: Implications for Biological Control.
  Entomopathogenic fungi (EPF) are well established as biological control agents, but their emerging role as endophytes reveals a broader and more powerful function in crop protection. By colonizing plant tissues, endophytic entomopathogenic fungi (EEPF) create …
  pubmed Hussien RHM, Kortsinoglou AM, Wood MJ, Kouvelis VN 等 2026 Jul 13 置信度 0.82
• Organ-on-a-Chip and Microfluidic Plant Cell Culture Systems: The Next Frontier for Controlled Secondary Metabolite Production and Real-Time Metabolomic Monitoring.
  Plant secondary metabolites remain indispensable for pharmaceuticals, nutraceuticals, and cosmeceuticals, yet conventional plant culture systems are increasingly limited by inconsistent yields, poor scalability, and inadequate capacity for real-time process mo…
  pubmed Dadhich A, Sharma V, Sivanesan I 2026 Jul 16 置信度 0.82
• The Genetic Transformation Mechanism and Application of Plant Hairy Roots.
  Innovation in plant-breeding technology relies on precise, targeted genetic manipulation, which depends on the efficient delivery of genetic elements and robust plant cell regeneration systems. Agrobacterium tumefaciens , a traditional medium for genetic mater…
  pubmed Liu H, Zhang Z, Bian G, Li P 2026 Jul 13 置信度 0.82
• KNOX1 Transcription Factors in Plants with a Special Focus on Horticultural Crops: A Review.
  Class I KNOX1 (KNOTTED1-like homeobox 1) transcription factors integrate gibberellin (GA), cytokinin (CK), and auxin (IAA) signaling to maintain shoot apical meristem identity and coordinate plant organogenesis. This review examines the structural conservation…
  pubmed Cai X, Chen K, Ye L, Bibi L 等 2026 Jul 9 置信度 0.82
• Modern Concepts in Precision Targeting of Acute Myeloid Leukemia Based on Principles of Molecular Oncology.
  Acute myeloid leukemia (AML) pathogenesis is deeply rooted in the concept of clonal evolution, in which hematopoietic stem cells experience an initial genetic insult, followed by the sequential acquisition of mutations leading to various disease phenotypes. Th…
  pubmed Yuan R, Mariano M, Cachia D, Badar T 等 2026 Jul 19 置信度 0.82
• Nanotechnological Strategies to Promote Skeletal Muscle Regeneration in Aging.
  During aging, skeletal muscle undergoes a decline in mass and strength. This condition, known as sarcopenia, involves many physiological and metabolic impairments, thus representing a healthcare, social, and economic burden. Various pharmacological and non-pha…
  pubmed Carton F, Malatesta M 2026 Jul 10 置信度 0.82
• Converting Food Waste into Value-Added Products: A Review on Current Technologies, Challenges, and Future Perspectives.
  Food waste has emerged as one of the most pressing global sustainability challenges because of its environmental, economic, and social implications. Nearly one-third of the food produced worldwide is lost or wasted each year, contributing to greenhouse gas emi…
  pubmed Baiano A 2026 Jul 22 置信度 0.82
• Evaluating Alternatives to Fetal Bovine Serum in the Development of Advanced Biomaterial-Based Tumor Models: Overcoming Challenges in Biofabrication.
  The development of next-generation organotypic platforms and disease models has proven crucial for the progress toward personalized therapeutic solutions in cancer. Fetal bovine serum (FBS) is a nutrient-rich cell culture supplement that contains essential fac…
  pubmed Quansah E, Rivera I, Pedrón-Haba S 2026 Jul 22 置信度 0.82
• Naturally Derived Psilocybin for Therapeutic Use: A Six-Criterion Framework for Evidence, Safety, and Benefit-Risk Considerations in Policy and Clinical Development.
  Naturally derived psilocybin is widely used, yet its therapeutic potential, pharmacological distinctiveness and regulatory feasibility remain understudied. This review evaluates the potential of naturally derived psilocybin using a six-criterion framework to e…
  pubmed Enriquez-Geppert S, Bevers L, Rosander A, Fodran P 等 2026 Jul 3 置信度 0.82
• RAGE Signalling in Acute Inflammatory Disorders: Therapeutic Potential of Natural Products.
  Acute inflammatory disorders, including acute lung injury, acute pancreatitis, ischaemia-reperfusion injury, and sepsis, are major clinical challenges characterised by rapid progression, a characteristic cytokine storm, and high mortality rates. The receptor f…
  pubmed Wang Q, Luo W, Wan Q, Li Y 等 2026 Jun 23 置信度 0.82
• Beyond image alignment: Challenges and emerging solutions for MSI-histology registration in multimodal spatial omics.
  Multimodal spatial omics integrates molecular distributions, cellular states, and tissue morphology within a shared spatial coordinate system, but reliable cross-modal registration remains a major barrier to reproducible quantitative analysis. Spatial omics mo…
  pubmed Liu J, Tang C, Ye Y, Jiang J 等 2026 Oct 1 置信度 0.82
• Engineering therapeutic super-competitor cells for educative cancer treatment and ecological replacement.
  Conventional cancer therapy has largely been organized around maximal cytotoxic elimination, yet intense tumor killing can impose evolutionary selection pressures that promote resistance, clonal escape, and relapse. Here, we propose therapeutic super-competito…
  pubmed Wang Y, Wu N, Liao Y, Li J 等 2026 Jul 27 置信度 0.82
• Metabolic fermentation pathways of microalgae for the synthesis of high-value chemical products.
  This review critically discusses the biochemical diversity of microalgae, particularly their carbohydrate and protein contents that can be converted via fermentation process into added valuable organic metabolites. It lays on processes such as alcoholic fermen…
  pubmed Matos ÂP, Molognoni L, Bianchini CB, Vadiveloo A 等 2026 Jul 27 置信度 0.82
• Ortho-alkyl phenylalkenoyl natural products: structural diversity, bioactivities and biosynthesis.
  Covering: up to 2026. Ortho -alkyl phenylalkenoyl-containing natural products, including cinnamoyl-containing nonribosomal peptides (CCNPs) and ortho -alkyl phenylalkenoic acids (APAs), are structurally and biologically diverse bacterial metabolites that have …
  pubmed Huang Q, Chen X, Ma S, Li Z 等 2026 Jul 27 置信度 0.82
• Artificial Intelligence in Bacteriophage Science: A Comprehensive Narrative Review of Applications, Challenges, and Translational Opportunities.
  Antimicrobial resistance and persistent biofilm-associated infections have renewed interest in bacteriophages as alternatives or complements to conventional antibiotics. However, broader therapeutic adoption remains constrained by slow phage discovery, incompl…
  pubmed Fortaleza JAG, Cabuhat KSP, Lagunzad HC, Panizales WB 等 2026 Jun 25 置信度 0.82
• Macrophage Membrane-Coated Nanoparticles for Immunomodulation and Bone Regeneration: Emerging Applications in Oral and Dental Implant Therapy.
  Macrophage membrane-coated nanoparticles (MMNPs) are an emerging class of biomimetic nanoplatforms that combine the immune-regulatory functions of macrophages with the structural versatility of synthetic nanoparticles (NPs). By retaining key membrane proteins …
  pubmed Derhambakhsh S, Fernandez-Medina T, Antunes E, Sikder S 等 2026 Jul 10 置信度 0.82
• Evolution of Whole-Cell Biosensor Detection Technology for PAHs and Their Halogenated Derivatives Driven by Performance Requirements.
  Polycyclic aromatic hydrocarbons (PAHs) and their halogenated derivatives are important targets in environmental monitoring and pollution control because of their persistence, bioaccumulation, and potential carcinogenicity. Reliable strategies for detecting th…
  pubmed Zhang J, Mao W, Xia S, Hu L 等 2026 Jul 10 置信度 0.82
• Adaptive Responses of Tropical Crops: A Multi-Scale Omics Integrated Perspective.
  Tropical regions sustain crops essential to global food security and economic development, notably sugarcane, banana, cassava, rubber and oil palm, yet these species face extreme and variable environments. This review synthesizes their adaptive strategies shap…
  pubmed Wang P, Li C, Wang D, Wu Q 等 2026 Aug 置信度 0.82
• Photocatalytic and Biotechnological Strategies for Remediation of Persistent Organic Pollutants: Mechanisms, Toxicity, and Antimicrobial Perspectives.
  Persistent organic pollutants (POPs) pose significant ecological and human health risks due to their persistence, bioaccumulation, toxicity, and global distribution. Conventional remediation methods are often inadequate for achieving complete mineralization, d…
  pubmed Okechukwu VO, Njobeh PB, Okonkwo JO 2026 Jul 27 置信度 0.82
• Goniothalamin as a Styryl-Lactone Toxicophore in Cancer Models: Electrophile-Driven DNA Damage, Reactive Oxygen Species-Endoplasmic Reticulum Stress Signaling and Detoxification-Relevant Safety Considerations.
  Goniothalamin (GTN), a natural styryl-lactone from the Goniothalamus genus, has demonstrated cytotoxic properties against a variety of human cancer cell lines with minimal effects on normal cells. Its traditional medicinal use and preliminary preclinical evide…
  pubmed Joković N, Pešić S, Novaković M, Krstić AD 等 2026 Aug 置信度 0.82
• Plant-derived antioxidants: Biosynthesis, refining and applications.
  With increasing awareness of health-oriented antioxidant diets, plant-derived antioxidants (PDAs) such as polyphenolics, terpenoids, vitamins, alkaloids and saponins, are promising alternatives to synthetic antioxidants (SAs). PDAs boost human immunity and hea…
  pubmed Qu S, Li Y, Lai Y, Wuyun T 等 2026 Nov 置信度 0.82
• Engineering nonconventional yeasts to produce carboxylic acids: Advances and Prospects.
  Due to their versatile carboxy group, carboxylic acids can be used as bio-based monomers for high-value-added industrial products with great market demand. In recent years, metabolic engineering of nonconventional yeasts to produce carboxylic acids from renewa…
  pubmed Zhang L, Fan Y, Shi W, Zhou X 2027 置信度 0.82
• Targeting PCNA in Cancer: A Paradigm Shift from Static Inhibition to Dynamic Network Modulation.
  Proliferating Cell Nuclear Antigen (PCNA) is a core protein in DNA replication and repair. Its functional dysregulation drives tumorigenesis and therapeutic resistance, making it a critical anticancer target. However, the fundamental conflict between PCNA's in…
  pubmed Lu S, Wang Y, Zhang H, Yan M 等 2026 置信度 0.82
• Navigating the Metabolic-Genomic Paradigm: Mitochondrial Reprogramming as a Driver of Cancer Plasticity.
  Breast cancer (BC) management has transitioned from histological classification to molecular subtyping, yet therapeutic resistance and intratumor heterogeneity remain critical clinical challenges. This review examines the emerging paradigm shift toward integra…
  pubmed Tzeng YT, Wen CY, Yong SB, Wen ZH 等 2026 置信度 0.82
• Next-generation insect pest management: genetic innovations and emerging biocontrol strategies.
  Pest insects represent a major challenge to agriculture and global food security. Existing insect control methods such as chemical insecticides are under increasing scrutiny because of their environmental impacts, and once-effective methods are facing reduced …
  pubmed Sansinenea E, Argentel-Martínez L, Peñuelas-Rubio O, Hwang H 等 2026 置信度 0.82
• NMR spectral simplification with imidazolium ionic liquid-coated silica nanoparticles.
  NMR spectral simplification is a powerful strategy for facilitating the analysis and structural characterization of complex mixtures. In this work, we present a nanoparticle-assisted protocol that employs positively charged imidazolium ionic liquid-coated sili…
  pubmed Yang Y, Huang B, Wang Q, Hou G 等 2026 Aug 置信度 0.82