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preprints
2024
置信度 0.74
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preprints
2025
置信度 0.74
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The anchor-away (AA) technique enables rapid depletion of nuclear proteins by tethering them to cytoplasmic anchors through rapamycin-induced heterodimerisation. Albeit powerful, in Saccharomyces cerevisiae, this system is restricted to rapamycin-resistant str…
preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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ABSTRACT Rapid gene activation requires transcription factors (TFs) to locate their target motifs within vast genomes. In bacteria, TF target search is accelerated by combining 3D diffusion with 1D sliding, called facilitated diffusion, yet whether eukaryotic …
preprints
2026
置信度 0.74
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Phlebotomus papatasi is a vector of Leishmania major , the etiologic agent of zoonotic cutaneous leishmaniasis, a disfiguring and debilitating disease. In this study, we identified fatty acids found on the exterior of eggs laid by female P. papatasi that could…
preprints
2025
置信度 0.74
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Abstract Exposure to asbestos is the primary cause of mesothelioma, however the processes underpinning its initiation and evolutionary trajectory remain elusive. To address this knowledge gap, we conducted whole exome sequencing and phylogenetic analysis of 27…
preprints
2026
置信度 0.74
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preprints
2025
置信度 0.74
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Motivation Linkage between population-wide biobanks and electronic health records (EHRs) opens new opportunities to study the genetic and epidemiological underpinnings of treatment outcomes. However, data extraction is often complex, and the lack of open, repr…
preprints
2025
置信度 0.74
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preprints
2026
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2026
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2026
置信度 0.74
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preprints
2025
置信度 0.74
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Detailed understanding of plasmid-host physiological interactions and recombinant protein expression is crucial for the design and optimization of plasmid DNA (pDNA) manufacturing processes. Successfully transformed host cells carrying one or more copies of a …
preprints
2025
置信度 0.74
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Metabolic engineering in plants represents a potent approach to tackling global challenges in agriculture, nutrition, and sustainability. This comprehensive review explores state-of-the-art strategies for manipulating primary and secondary metabolic pathways i…
preprints
Katie Fan
2024
置信度 0.74
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preprints
2026
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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ABSTRACT Microbes have evolved a variety of strategies to survive exposure to naturally occurring and synthetic antimicrobials. These strategies have been investigated extensively in model bacterial organisms, whereas less is known about under explored pathoge…
preprints
2026
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2024
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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The analysis of scientific communities and collectives are central to STS and the sociology of science. Reviewing practices, that is, practices of ordering, defining or delineating scientific fields can be understood as an often neglected, yet prevailing textu…
crossref
Clemens Blümel
2020-04-08T09:28:46Z
置信度 0.70
-
crossref
Ernest L. Plummer
2004-03-01T23:36:12Z
置信度 0.70
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crossref
F. Haurowitz
2004-03-01T12:44:16Z
置信度 0.70
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crossref
Gisela Kramer
2004-03-02T01:07:40Z
置信度 0.70
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The new research field of synthetic biology is emerging from molecular biology, chemistry, biotechnology, information technology and engineering. This paper describes synthetic biology as a ‘Science of the Artificial’ and identifies structural features of engi…
crossref
Marc-denis Weitze, Alfred Pühler
2014-05-13T12:39:14Z
置信度 0.70
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Microplastic pollution has emerged as a critical environmental challenge, yet existing remediation strategies remain limited in their ability to achieve more complete mineralization under environmentally relevant conditions. In this review, we examine differen…
crossref
Hening Guo, Tsz Yam Liu, Tianlin Wen, Mingce Yang 等
2026-07-21T05:34:53Z
置信度 0.70
-
crossref
Silvia Basanta, Mihaela Pavlicev
2025-08-14T18:13:57Z
置信度 0.70
-
crossref
Xiucai Liu
2023-06-08T11:31:14Z
置信度 0.70
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europepmc
2026
置信度 0.80
-
Covering: up to December 2025The incorporation of distinctive structures such as uncommon functional groups, distinct molecular scaffolds, unusual modifications and other characteristic structural features can significantly enhance metabolic stability, bioacti…
pubmed
Shi S, Jin X, Wang G, Hao X 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Lignin, a major constituent of lignocellulosic biomass, represents an abundant yet underexploited renewable aromatic reservoir. Unlocking its value requires not only efficient depolymerization but also a clear understanding of how depolymerization routes inter…
pubmed
Zhang SY, He ZJ, Wang C, Zhang N 等
2026
置信度 0.82
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Bottom-up synthetic cells are frequently framed as enabling technologies for a future green bioeconomy, yet their environmental impacts remain poorly quantified. Here, we review and synthesize available life cycle assessment (LCA) data for the feedstocks, prod…
pubmed
Hopf C, Ravandeh M, Steinkühler J
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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Disorazoles are a family of exceptionally potent, macrodiolide natural products originally isolated from the myxobacterium Sorangium cellulosum. They exert picomolar cytotoxicity by disrupting microtubule dynamics, placing them among the most potent Microtubul…
pubmed
Fu G, Li H, Li R, Tu Q 等
2026
置信度 0.82
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Soil microbiomes are essential for nutrient cycling, plant health, stress resilience, and sustainable agriculture. Recent advances in high-throughput sequencing, multi-omics technologies, systems biology, and artificial intelligence (AI) have transformed our u…
europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Membrane-associated biomolecules, primarily proteins, are key enablers of communication, responsiveness, and complexity in natural living cells. Aiming to mimic these capabilities, there is growing interest in equipping bottom-up synthetic cells with membrane-…
pubmed
Dack C, Li B, Newell C, Booth MJ
2026
置信度 0.82
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europepmc
2027
置信度 0.80
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Natural killer (NK) cells are key components of the innate immune system and play a pivotal role in tumor immunosurveillance. In recent years, a subset of NKG2C + adaptive NK cells induced by human cytomegalovirus (HCMV) infection has attracted considerable at…
pubmed
Tang Q, Tian Z, Bi J
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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Arsenic contamination of drinking water remains a persistent global health burden and an environmental justice challenge, particularly for low-resource communities that lack access to reliable monitoring tools. Synthetic-biology-driven biosensors offer a promi…
pubmed
Zeballos Huarachi OS, Tambo Santos AA, Aliaga Rodriguez JJ, Porcel Velasquez AK 等
2026
置信度 0.82
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In embryos, intrinsic and extrinsic signals cooperatively shape cellular decisions to form tissues and organs. Developmental engineering seeks to harness insights into the molecular mechanisms governing embryonic development and leverage pluripotent stem cells…
pubmed
Taheri MN, Xiang Y, Ebrahimkhani MR
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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Transposons are fundamental genetic elements that have profoundly shaped the architecture of eukaryotic genomes. Yeasts and filamentous fungi have emerged as important chassis organisms for bioingredient production in synthetic biology and metabolic engineerin…
pubmed
Peng B, Tominaga M, Wang C, Speight RE 等
2026
置信度 0.82
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Gut Bacteroides are abundant and critical to human health, yet most are genetically cumbersome, non-model microbes. A widely applicable editing tool for Bacteroides is essential for gut microbiome manipulation. Here, we develop STIB (ShCAST-based transient ins…
pubmed
Hu Y, Li Q, Li Y, Zeng Y 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
-
Small non-coding RNAs (sRNAs) are ubiquitous post-transcriptional regulators that enable rapid bacterial adaptation to fluctuating environments. Previous reviews have largely focused on sRNA mechanisms in model organisms. This review integrates computational p…
pubmed
Nawaz MA, Nawaz MZ, Haider SZ, Alghamdi HA 等
2026
置信度 0.82
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Coastal ecosystems play critical roles in biogeochemical cycling, food webs, climate regulation, and aquaculture. Their functions are shaped by multitrophic interactions across microbe-microbe, microbe-plant, and microbe-animal interfaces, yet our understandin…
pubmed
Qian L, Su R, Wang W, Yan B 等
2026
置信度 0.82
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The cross-species delivery of megabase-scale synthetic DNA molecules, from microorganisms into mammalian cells, remains a major challenge for synthetic genomics. Recently, we developed nucleus isolation for chromosome extraction (NICE), a method that enables t…
pubmed
Liu Y, Zhou J, Liu Z, Yuan YJ
2026
置信度 0.82
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Liquid-liquid phase separation (LLPS) utilizes dynamic, membrane-less compartmentalization to spatially organize and control biochemical processes, which advances synthetic biology fields such as synthetic metabolic engineering and artificial cell construction…
pubmed
Zhang K, Wan Y, Jia X, Fang X 等
2026
置信度 0.82
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Terpenoids are valuable natural products that are widely used in medicine, agriculture, energy, and food. Traditional production by plant extraction or chemical synthesis is inefficient, costly, and polluting. Microbial fermentation via synthetic biology offer…
pubmed
Cheng M, Gao X, Shen R, Liang X 等
2026
置信度 0.82
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Sarcopenia, the age-related loss of muscle mass and function, is a major barrier to healthy aging. However, its molecular origins remain obscure, and current clinical tools lack the sensitivity needed to detect risk before significant decline occurs.
pubmed
Sun J, Yan M, Jiang D, Yang C 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Tumor immunotherapy has revolutionized cancer treatment by harnessing the immune system to recognize and eliminate malignant cells. However, limited response rates, systemic toxicity, and tumor heterogeneity remain major challenges. Synthetic gene circuits - e…
europepmc
2026
置信度 0.80
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Biosecurity threats are issues of public health importance because of their implications for global health security. Although some strategies have been implemented by global organizations to mitigate risks from natural, accidental, or deliberate biological thr…
pubmed
Ijarotimi OA, Amuda AA, Omokanye CO, Amuda M
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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The field of engineered living materials (ELMs) aims to create self-regenerative, self-assembled, and multifunctional materials that mimic natural biomaterials. Novel ELMs can be produced by engineering biomolecules that are naturally secreted and displayed on…
pubmed
Nguyen CHC, Suggs O, Ajo-Franklin CM
2026
置信度 0.82
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Inflammasomes, particularly the NLRP3 complex, play a central role in coordinating innate immune activation and neuroinflammatory responses within the cytosol. Persistent or dysregulated nucleotide-binding domain, leucine-rich-containing family, pyrin domain-c…
pubmed
Waseem A, Ghosh S, Kumari M, Raza SS 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Synthetic biology aims to re-engineer living cells into autonomous computational chassis capable of executing sophisticated biological tasks. Within this framework, programmable nucleic acid-based logic networks have emerged as a versatile molecular control la…
europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Cell division is a fundamental process essential for life, underpinning reproduction, development and tissue maintenance across all organisms and enabling population growth and evolutionary adaptation. Recreating this capability is, therefore, a central challe…
pubmed
Dommisse J, Lira RB, Dekker C
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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Synthetic microbial communities offer valuable insights into the mechanisms that govern community functions, and they can be designed to achieve desired functions in order to address societal challenges in precision medicine and agriculture. Existing computati…
pubmed
Qian Y, Menon SD, Huang H, Quinn-Bohmann N 等
2026
置信度 0.82
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Transfer RNA (tRNA) acts not only as an indispensable adaptor in protein synthesis but also as a key contributor to tumorigenesis when its regulation is disrupted. This review systematically summarizes aberrant tRNA-related mechanisms in cancer, including alte…
pubmed
Jian N, Ren H, Huang Y, Ma L 等
2026
置信度 0.82
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Microbial communities drive fundamental processes across the globe, from biogeochemical cycling to human health. Yet, their complexity often obscures mechanistic understanding. Synthetic communities (SynComs) have emerged as powerful tools to distill this comp…
pubmed
Suazo DD, Wang E, Taga ME
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Engineered live biotherapeutic products (eLBPs) represent an emerging class of programmable microbial therapies capable of sensing and responding to host physiology. Advances in microbiome science and synthetic biology have driven the development of engineered…
pubmed
Brown EA, Brevi A, Zong DM, Zarrinpar A
2026
置信度 0.82
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Synthetic biology is reshaping cancer immunotherapy by enabling living therapeutics that sense, compute, and act within tumors. This review categorizes recent advances across three modalities: engineered CAR-T cells, oncolytic bacteria, and oncolytic viruses. …
europepmc
2026
置信度 0.80
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The escalating atmospheric CO 2 concentration, exceeding 430 ppm since the pre-industrial era, presents a critical threat to global climate stability. Moving beyond mere carbon capture, this review synthesizes cutting-edge advancements in technology-drive…
pubmed
Chen S, Pi C, Zhang B, Wu X 等
2026
置信度 0.82
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Surface coating modification of medical devices is an effective strategy to overcome interfacial incompatibility and associated biological complications encountered in clinical applications. Among various coating materials, functional hydrogel coatings can imp…
pubmed
Li S, Guo Z, Dong A
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Plants have long served as natural indicators of environmental conditions, and recent advances in synthetic biology are enabling the design of engineered sentinels - living sensors that can report on abiotic and biotic stressors. This review summarizes recent …
pubmed
George W, Wheeldon I, Cutler S
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Predictable design is central to realizing the potential of plant genetic circuits by linking regulatory architecture to phenotypic outcomes. Despite rapid advances in genetic parts and circuit construction, most plant circuits are still developed through empi…
europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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The environmental deployment of functional nanoparticles requires synthesis routes that are simultaneously mild, scalable, and field-compatible. While microbial pathways offer a green alternative to traditional chemistry, achieving laboratory-grade precision i…
pubmed
Ma A, Li S, Hou Q, Zhuang X 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80