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• Mitochondrial engineering strategies in yeast cell factories.
  Yeast is widely used as a microbial chassis for sustainable chemical production, with subcellular organelles helping to organize and regulate biosynthesis. Among these organelles, mitochondria play pivotal roles in yeast cell factories by supplying metabolic r…
  pubmed Yang S, Gao C, Hu G, Li X 等 2026 置信度 0.82
• Bioengineered bacteria in cancer immunotherapy: mechanistic advances, therapeutic strategies and clinical potential.
  Bioengineered bacteria have emerged as a transformative platform in cancer immunotherapy, offering unique opportunities for selective tumour targeting, immune modulation, and localised delivery of therapeutic molecules. Their natural ability to colonise hypoxi…
  pubmed Vadakkan K, Karippali S, Jacob J, Gunasekaran S 等 2026 置信度 0.82
• Morphogenesis of multicellular glandular trichomes in plants.
  europepmc 2026 置信度 0.80
• Programming the translational landscape for predictable gene expression.
  Precision engineering of biological systems requires multi-layered control of gene expression, where translational regulation serves as a critical intermediary balancing response speed and metabolic cost. This review explores the multi-faceted landscape of tra…
  pubmed Yan W, Hu G, Liu K, Liang G 等 2026 置信度 0.82
• Writing Big in Plant Genomes: Advances, Challenges and Strategies for Targeted Large-Fragment DNA Insertion.
  europepmc 2026 置信度 0.80
• BATPC: A biology-anchored tumor progression classification for interpreting multidimensional progression phenotypes across solid tumors.
  Conventional size-based criteria such as RECIST collapse biologically diverse progression patterns into a single "progressive disease" label, obscuring clinically meaningful heterogeneity. As multimodal monitoring and immunotherapy become central to oncology, …
  pubmed Gupta YK 2026 置信度 0.82
• Recent advances in proximity labeling: New chemistries, optical control and programmable reaction boundaries.
  Proximity labeling (PL) has become a broadly used chemical strategy for mapping molecular neighborhoods in living systems. Recent advances are shifting the field from expanding the PL toolbox toward engineering the reaction boundary that defines what is labele…
  pubmed Fang Y, Wang G, Zou P 2026 置信度 0.82
• Computational selection of allosteric RNAs: A review.
  europepmc 2026 置信度 0.80
• Review for "Synthetic biology in biofilms: Tools, challenges, and opportunities"
  crossref 2021-01-15T18:19:22Z 置信度 0.70
• Review for "Synthetic biology in biofilms: Tools, challenges, and opportunities"
  crossref 2021-01-15T18:19:22Z 置信度 0.70
• Review for "Synthetic biology in biofilms: Tools, challenges, and opportunities"
  crossref 2021-01-15T18:19:22Z 置信度 0.70
• Review for "Synthetic biology in biofilms: Tools, challenges, and opportunities"
  crossref 2021-01-15T18:19:22Z 置信度 0.70
• Review: Sustainable construction: Toward growing biocement with synthetic biology - R0/PR3
  crossref 2023-08-29T06:44:51Z 置信度 0.70
• Review: Sustainable construction: Toward growing biocement with synthetic biology - R0/PR2
  crossref 2023-08-29T06:44:51Z 置信度 0.70
• Review: Sustainable construction: Toward growing biocement with synthetic biology - R1/PR6
  crossref 2023-08-29T06:44:51Z 置信度 0.70
• Review for "Synthetic biology in biofilms: Tools, challenges, and opportunities"
  crossref 2021-01-15T18:19:22Z 置信度 0.70
• Review for "Synthetic biology for heterologous expression and engineering of fungal polyketide synthases"
  crossref 2026-03-02T21:02:16Z 置信度 0.70
• Review of quantitative and qualitative studies on U.S. public perceptions of synthetic biology
  crossref Eleonore Pauwels 2009-10-08T22:50:37Z 置信度 0.70
• Book Review of <i>Synthetic Biology: A Lab Manual</i>
  crossref Jessica C. Hsueh, Kara J. Helmke 2014-12-19T00:03:50Z 置信度 0.70
• <i>Synthetic Biology and Greenhouse Gases</i>
  crossref Pablo I. Nikel 2026-08-14T19:03:46Z 置信度 0.70
• Synthetic Biology and International Regulatory Law
  For the purpose of constructing or generating new life forms, synthetic biology is a multidisciplinary field that blends biology with engineering, physics, mathematics, chemistry, and computer science. Making Biobricks, designing metabolic pathways, whole-geno…
  crossref Birhan Getie, Berhanu Andualem 2024-01-19T12:38:51Z 置信度 0.70
• <i>Synthetic Dyes in Biology, Medicine and Chemistry.</i>Edward Gurr
  crossref 2004-03-01T21:19:54Z 置信度 0.70
• Faculty Opinions recommendation of SYNTHETIC BIOLOGY. Emergent genetic oscillations in a synthetic microbial consortium.
  crossref Jason McDermott 2015-09-14T10:25:19Z 置信度 0.70
• Review of Synthetic Biology – Metabolic Engineering by Huimin Zhao and An-Ping Zeng (Editors)
  Synthetic biology is the engineering approach to edit or write the genome aiming to design the biological devices (promoters, transcription factors, TFBS, terminators etc.) of an organism to achieve the improved properties, while, metabolic engineering aiming …
  crossref Muhammad Ahmed 2020-04-23T14:57:55Z 置信度 0.70
• Review for "Synthetic biology as a game-changer for endangered medicinal orchids: Biosynthesis, engineering and conservation"
  crossref 2026-06-02T12:24:36Z 置信度 0.70
• Review for "Synthetic biology as a game-changer for endangered medicinal orchids: Biosynthesis, engineering and conservation"
  crossref 2026-06-02T12:24:36Z 置信度 0.70
• Review for "Synthetic biology as a game-changer for endangered medicinal orchids: Biosynthesis, engineering and conservation"
  crossref 2026-06-02T12:24:36Z 置信度 0.70
• Synthetic biology: Too early for assessments? A review of synthetic biology assessments in Germany
  crossref D. van Doren, N. B. Heyen 2014-06-12T07:44:44Z 置信度 0.70
• Peer Review Report For: Accessing Nature’s diversity through metabolic engineering and synthetic biology [version 1; peer review: 2 approved]
  crossref 2025-11-25T16:12:09Z 置信度 0.70
• Peer Review Report For: Accessing Nature’s diversity through metabolic engineering and synthetic biology [version 1; peer review: 2 approved]
  crossref 2025-11-25T08:12:05Z 置信度 0.70
• <i>Blood Compatible Synthetic Polymers. An Introduction.</i>Stephen D. Bruck
  crossref 2004-03-01T16:15:28Z 置信度 0.70
• <i>Synthetic Polypeptides. Preparation, Structure, and Properties.</i>C. H. Bamford
  crossref 2004-03-01T14:56:34Z 置信度 0.70
• Faculty Opinions recommendation of Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development.
  crossref Frank Seeber 2016-05-31T10:10:09Z 置信度 0.70
• Faculty Opinions recommendation of RNA synthetic biology.
  crossref Gabriele Varani 2012-09-18T20:54:32Z 置信度 0.70
• BAMBI acts as a molecular switch to determine the cell fate of C2C12 myoblasts.
  Myogenesis is a tightly regulated process by a cascade of well-coordinated events and pathways. In addition to the known myogenic regulatory factor (MRF) family, including Myf5, MyoD, myogenin, and MRF4, our previous study identified that BAMBI is involved in …
  pubmed Yao X, Xie L 2026 Aug 1 置信度 0.82
• Highlighting the genetics of natural and synthetic selfish elements in a special GENETICS and G3 series.
  Recognizing the broad importance of selfish elements, the GSA journals have established a series to highlight the genetic mechanisms and evolutionary consequences of selfish non-Mendelian inheritance. GENETICS and G3 invited high-quality submissions with a foc…
  pubmed Larracuente AM, Gould F, Dyer KA 2026 Aug 5 置信度 0.82
• Polygonatum odoratum extract ameliorates acetaminophen-induced acute liver injury by modulating the gut-liver axis and remodeling microbial and ceramide metabolism to suppress hepatic ferroptosis: insights from multi-omics.
  Drug-induced liver injury remains a major clinical challenge due to the lack of effective therapeutic options. Polygonatum odoratum extract (PO), derived from the traditional medicinal and edible plant Polygonatum odoratum (Mill.) Druce , has long been used in…
  pubmed Qin H, Chen R, Shi Y, Li C 等 2026 置信度 0.82
• Mechanisms of PARP Inhibitor Resistance: From Replication Gap Biology and Transcription-Replication Conflicts to PROTAC-Based Next-Generation Strategies.
  Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) have transformed precision oncology by exploiting synthetic lethality in homologous recombination (HR)-deficient cancers, with multiple FDA-approved agents targeting BRCA1/2-mutant tumors. Despite initial e…
  pubmed Abinawanto, Sophian A 2026 Jun 置信度 0.82
• Origin, Conservation and Functional Diversification of the BES1/BZR1 Gene Family During Early Land Plant Terrestrialization in Bryophytes.
  BRI1-EMS-SUPPRESSOR 1 (BES1)/BRASSINAZOLE-RESISTANT 1 (BZR1) transcription factors serve as core regulators of brassinosteroid (BR) signal in seed plants, where they control diverse developmental processes, including cell elongation, vascular development, and …
  pubmed Yang H, Li L, Li Y, Liang B 等 2026 Aug 4 置信度 0.82
• Mechanism of Terpene Formation in Pogostemon cablin cv. Jing Huoxiang Revealed by Metabolome and Transcriptome Analysis.
  Pogostemon cablin (Blanco) Benth. cv. 'Jing Huoxiang', is a valuable medicinal plant widely studied for its aboveground tissues, which are rich in bioactive compounds such as patchouli alcohol. However, systematic investigations into the biosynthesis of sesqui…
  pubmed Ma W, Wan X, Yao G, Wang F 等 2026 Jul 30 置信度 0.82
• PARP Inhibitor Sensitivity in Tumors Harboring Non-BRCA Homologous Recombination Gene Alterations: Current Evidence Across Ovarian, Breast, Prostate, and Pancreatic Cancers.
  Poly(ADP-ribose) polymerase inhibitors (PARPis) have demonstrated remarkable efficacy in tumors carrying BRCA1/2 pathogenic variants (PVs) through the mechanism of synthetic lethality. PVs in other homologous recombination (HR) genes may also impair homologous…
  pubmed Dos Santos ES, Cicilini AL, Simões MFE, Baz M 等 2026 Jul 28 置信度 0.82
• Genome-Wide Identification and Functional Verification of Core Berberine Bridge-like Enzyme Genes for Benzylisoquinoline Alkaloid Biosynthesis in Corydalis saxicola Bunting.
  Benzylisoquinoline alkaloids (BIAs) are significant defensive and pharmaceutical metabolites found in medicinal plants of the Papaveraceae family. Among these, dehydrocavidine is a distinctive bioactive constituent of Corydalis saxicola Bunting, an endangered …
  pubmed Kang L, Liu H, Zhu D, Li C 等 2026 Jul 27 置信度 0.82
• Establishment of a Keratin 14/17-Induced Antigen-Specific Psoriasis-like Mouse Model.
  Psoriasis is a chronic inflammatory autoimmune skin disease significantly impairing the patients' quality of life. Keratin (K)14 and K17 are abnormally expressed in psoriasis patients and considered to be potential autoantigens triggering this disease. However…
  pubmed Wang L, Tang Y, Li W, Zhu P 等 2026 Aug 3 置信度 0.82
• Fruit-Specific Promoters in Plants: Advances, Regulatory Mechanisms and Applications in Plant Biotechnology.
  Fruit-specific promoters (FSPs) are a class of regulatory DNA sequences that direct transgene expression exclusively in fruit tissues or during specific stages of fruit development. They are indispensable molecular tools in modern agricultural biotechnology, w…
  pubmed Fan J, Tang X, Wang A, Zhang L 等 2026 Jul 29 置信度 0.82
• Cyanobacterial Circadian Clock: Molecular Mechanisms and Physiological Outputs.
  Earth's rotation produces day and night cycles that are a primary selective pressure driving the evolution of endogenous circadian clocks. Cyanobacteria are the most studied prokaryotic model, and their timekeeping core is a protein oscillator composed of KaiA…
  pubmed Hu X, Ning X, Zhang J, Zhu D 2026 Jul 27 置信度 0.82
• Functional Characterization of GmRD22 Modulating Nitrogenase Activity in Soybean with Transcriptomic Comparison Between Two Genotypes.
  Soybean ( Glycine max ) is a key crop in China grown as a source of edible oil and plant-derived protein, and its production is closely linked to national food security. Insufficient nitrogen availability remains a key constraint on soybean yield. In legumes, …
  pubmed Zhao H, Zhong J, Ma C, Wang T 等 2026 Jul 25 置信度 0.82
• In Silico Design of phaCAB Expression Constructs for Cellulolytic Hosts Toward Hemp Hurd Valorisation and Polyhydroxybutyrate Biosynthesis.
  Hemp hurds (HHs), an underutilised lignocellulosic biomass (LB) from agricultural waste, offer potential for bioconversion into high-value bioproducts within a circular bioeconomy. Building on prior work involving magnetic nanoparticle-immobilised cellulase hy…
  pubmed Myeni ZR, Gumede S, Ntombela N, Dziike F 等 2026 Aug 6 置信度 0.82
• Mutagenesis and Analysis for Enhancing (2R,3R)-2,3-Butanediol Tolerance and Production in Corynebacterium glutamicum.
  2,3-Butanediol (2,3-BD) is a versatile bulk chemical, serving as a high-boiling green solvent, a key monomer for polyesters and polyurethanes, and a crucial intermediate in the production of fine chemicals and cosmetics. Additionally, it is a key intermediate …
  pubmed Liu Z, Cui H, Jiang Y, Wang Z 等 2026 置信度 0.82
• Conformational Behavior and Self-Assembly of Gallol-Containing Block Copolymers in Non-Polar Media.
  While previous studies have illuminated the behavior of poly(gallol methacrylate)- block -poly( N -phenylmethacrylamide) copolymers ( PM- b -PNP ) in polar alcoholic mixtures, their performance in non-polar environments remains an uncharted territory. In this …
  pubmed Balabaev NK, Poddar P, Shit S, Chvalun SN 等 2026 Aug 3 置信度 0.82
• Fructans and Fructooligosaccharides in Plants and Fruits: Metabolism, Functional Roles, and Emerging Biotechnological Opportunities.
  Fructans and fructooligosaccharides (FOSs) are structurally diverse fructose-based carbohydrates synthesized from sucrose through the coordinated action of fructosyltransferases. These compounds are widely distributed in plants and have attracted increasing at…
  pubmed Morales-Quintana L, Ramos P, Parra-Palma C 2026 Jul 30 置信度 0.82
• UV-He-Ne Laser Sequential Mutagenesis Improves Protease Production of Bacillus velezensis: Comparison with Traditional UV Mutagenesis.
  This study combined the damage effect of UV and the repair effect of He-Ne laser, employing UV-He-Ne laser (UV-LA) sequential mutagenesis to improve the protease-producing ability of Bacillus velezensis . Compared with UV mutagenesis, UV-LA treatment elevated …
  pubmed Liu Y, Duan Y, Luo L, Tuly JA 等 2026 Jul 23 置信度 0.82
• bHLH Family Transcription Factors: Molecular Switches in Plant Specialized Metabolism.
  Plant specialized metabolites connect genetic programs and environmental responses with ecologically and economically valuable natural products. Their accumulation is rarely constitutive, varying instead with tissue identity, developmental stage, stress exposu…
  pubmed Han X, Chen G, Peng J, Cao N 等 2026 Aug 3 置信度 0.82
• Glucose-responsive probiotics for glycaemic modulation in mice and monkeys.
  Sustained and controlled delivery of glucose-lowering agents using engineered designer cells is recognized as an effective strategy for diabetes therapy 1 . However, current technologies rely on external signal control or have been programmed into mammalian ce…
  pubmed Guan N, Kong D, Gao X, Niu L 等 2026 Aug 12 置信度 0.82
• Enhanced polyphenolic production in tissue culture-derived Opuntia ficus-indica increases larvicidal activity against Spodoptera exigua: biochemical, histological and molecular docking evidence.
  The accelerating resistance of Spodoptera exigua to synthetic insecticides demands the development of eco-friendly botanical alternatives. Plant tissue culture provides a controlled means to enhance the biosynthesis of defense metabolites. This study explored …
  pubmed Elqady EM, El-Said E, Moustafa MAM, Almozini RN 等 2026 Aug 12 置信度 0.82
• Pattern-Filter structural validation of single-cell RNA-seq reads reduces artifactual barcodes and improves biological resolution.
  Single-cell RNA sequencing (scRNA-seq) pipelines rely on the assumption that sequencing reads possess correct structural architecture, a premise we show is incomplete. Standard quantification tools treat errors exclusively as base mismatches, failing to identi…
  pubmed Su Q, Zhou X, Long Y, Duan F 等 2026 置信度 0.82
• Structurally coupled polysaccharide-lignin tri-domain phyto-cryogel for microenvironment buffering of oxidative and microbial stress in diabetic wounds.
  Infected diabetic wounds face a dual therapeutic challenge of rapid biomaterial degradation under combined oxidative-osmotic stress, and mechanical collapse of conventional redox-active polysaccharide gels upon prolonged wet-state exposure. To address these ch…
  pubmed Abdelmula WIY, Gorish BMT, Liu B, Dang W 等 2026 Oct 1 置信度 0.82
• Stretchable, self-adhesive conductive hydrogels based on gelatin and oxidized hydroxyethyl starch as flexible sensors and bioelectrodes.
  Natural polymer based-hydrogels have attracted increasing attention as flexible wearable sensors owing to their excellent biocompatibility. However, hydrogels derived from natural polymers with balanced mechanical and adhesive properties still remain a challen…
  pubmed Lu J, Meng Y, Shu Y, Yang M 等 2026 Oct 1 置信度 0.82
• Integrative quantum and systems biology of cancer: From molecular fluctuations to ecological outcomes.
  This review treats cancer as a multiscale adaptive system, asks what the framework must predict to be worth adopting, and separates at each scale what the evidence establishes from what is proposed. It is an expert narrative synthesis, not a systematic review,…
  pubmed Casotti MC, Ferreira BC, Campanharo BP, Campanharo CV 等 2026 置信度 0.82
• The MHC-I related protein 1 MR1 can bind host purine catabolites.
  The major histocompatibility complex class I-related molecule (MR1) is a non-classical antigen-presenting protein that presents a diverse array of microbial, synthetic and host-generated small metabolites to mucosal-associated invariant T (MAIT) cells and othe…
  pubmed Abdelaal MR, Lim XY, Mak JYW, Fairlie DP 等 2026 Aug 12 置信度 0.82
• High-throughput screening coupled with laboratory adaptive evolution to enhance acid-tolerance and succinic acid production of Actinobacillus succinogenes.
  The development of efficient bio-based succinic acid production technology holds significant importance for reducing carbon emissions and advancing the industrial production of biodegradable plastics. Actinobacillus succinogenes is a natural high-yield succini…
  pubmed Zhou S, Zhang X, Deng Y 2026 Aug 12 置信度 0.82
• REvolutionH-tl 2.0: A fast and robust tool for decoding evolutionary gene histories.
  REvolutionH-tl is a fast, scalable, and integrated software platform for inferring orthology relationships, gene trees, species trees, and reconciled evolutionary scenarios directly from sequence data. Built upon the formal framework of best match graphs (BMGs…
  pubmed Ramírez-Rafael JA, Korchmaros A, Aviña-Padilla K, López-Sánchez A 等 2026 Aug 置信度 0.82
• Metal Coordination Dynamics Governs Selective Halogenation in α-KG/Fe-Dependent Halogenase SyrB2.
  &#x3b1;-Ketoglutarate (&#x3b1;-KG)-dependent nonheme iron enzymes catalyze a diverse array of oxidative transformations essential for natural product biosynthesis. However, the mechanism by which &#x3b1;-KG/Fe-dependent halogenases achieve selective halogenati…
  pubmed Yuan W, Huang J, Liu J, Feng J 等 2026 Aug 12 置信度 0.82
• Hydrophobic unnatural base pair promotes trigger loop closure and catalysis in cellular RNA polymerase independent of hydrogen bonding.
  Expanded genetic alphabets based on synthetic nucleotides offer a powerful strategy to increase the chemical diversity and functional potential of nucleic acids. Hydrophobic unnatural base pairs (UBPs) represent a unique class of UBPs that operate without cano…
  pubmed Li Q, Hou P, Kimoto M, Oh J 等 2026 Aug 18 置信度 0.82
• Unlocking the bacterial condensome: from 'dark matter' to design.
  Biomolecular condensates have transformed our understanding of eukaryotic cellular organization, yet their roles in bacteria remain comparatively underexplored. This gap arises from the physical constraints of bacterial cell size, the diversity of molecular me…
  pubmed Trettel DS, Mak CA, Hoang Y 2026 Aug 12 置信度 0.82
• The iModulon framework: how x-AI reveals microbial regulatory logic.
  The accelerating deposition of RNAseq data over the past decade has motivated the development of advanced transcriptomic data analytics that can operate on a large number of samples. One successful approach is to apply independent component analysis (ICA) to l…
  pubmed Kim K, Catoiu EA, Lee Y, Lee D 等 2026 置信度 0.82
• Periplasmic Engineering Enhances Terminal Hydroxylation for Efficient Caffeic Acid Biosynthesis in Escherichia coli.
  Caffeic acid (CA) is a valuable phenylpropanoid with applications in food, pharmaceutical, and chemical industries. Microbial production of CA is often limited by the terminal hydroxylation catalyzed by 4-hydroxyphenylacetate 3-monooxygenase (HpaBC). Here, we …
  pubmed Wang S, Zhuo Y, Tuly JA, Zabed HM 等 2026 Aug 12 置信度 0.82
• Regulatory cascade of NdpR and NdpR2 in controlling nicotine degradation operons in Sphingomonas melonis TY.
  In Sphingomonas melonis TY, the TetR-family NdpR and AraC-family NdpR2 coregulate nicotine catabolism. Despite overlapping target promoters, their hierarchical relationship remained unclear. Here, we elucidate a multi-layered cascade regulatory network where N…
  pubmed Tang Q, He Z, Wang S, Cheng Y 等 2026 Aug 12 置信度 0.82
• A poly(A)-independent PacBio strategy for organellar transcriptome profiling.
  pubmed Gu X, Wang J, Nie L, Zhang S 等 2026 Aug 4 置信度 0.82
• ChronoSort: Revealing Hidden Dynamics in AlphaFold3 Structure Predictions.
  Protein function emerges from dynamic conformational changes, yet structure prediction methods provide only static snapshots. While AlphaFold3 (AF3) predicts protein structures, the potential for extracting dynamic information from its ensemble predictions has…
  pubmed Argyle MJ, Heaps WP, Kubalek C, Gardiner SS 等 2025 Dec 置信度 0.82
• Smart closed-loop drug delivery systems.
  The administration of therapeutics for long-term chronic disease management or treatment faces considerable challenges, such as the need for precise dosage control, timely delivery and adherence to medication regimens. Traditional drug delivery methods often r…
  pubmed Paci MM, Saha T, Djassemi O, Wu S 等 2025 Oct 置信度 0.82
• Clinical translation of epigenome editing technologies.
  CRISPR/Cas-based epigenome editing technologies hold great promise for identifying novel therapeutic targets, improving gene and cell therapies, and directly addressing the underlying issues in many diseases, all while minimizing risks of genotoxicity often as…
  pubmed Ma AJ, Brown BH, Kim S, Hilton IB 2026 Jun 置信度 0.82
• Molecular mechanisms of bacteria-mediated cancer immunotherapy: from intratumoral microbiota to engineered therapeutics.
  Immunotherapy has redefined oncology, yet its efficacy remains constrained by low response rates, primary or acquired resistance, immune-related toxicities, and escalating costs. Bacteria-mediated cancer immunotherapy (BCIT), which exploits the intratumoral mi…
  pubmed Guo J, Li Y, Yang Y, Wang B 2026 置信度 0.82
• From Mechanism to Clinic: Engineered Bacteria-Nanomaterial Hybrid Systems for Cancer Immunotherapy.
  Hypoxia, immunosuppression, and pronounced heterogeneity within the tumor microenvironment (TME) hinder the effectiveness of cancer therapies. Engineered bacteria-nanomaterial hybrid systems have emerged as a promising approach to address these challenges. Bac…
  pubmed Lin J, An M, Dai Y, Huang Y 等 2026 置信度 0.82
• Strengthening global biosecurity for synthetic nucleic acid technology: from sequence screening to risk-based governance in the AI era.
  Synthetic nucleic acid technology has expanded rapidly, reducing the cost, time, and technical barriers associated with DNA and RNA synthesis. Existing governance frameworks have focused mainly on sequence-based screening of synthesis orders and customer verif…
  pubmed Kato SE, Ndudzo A, Bayiga SO, Brenda N 等 2026 置信度 0.82
• Partitioning of parental histones between leading and lagging strands is modulated by DNA polymerase dosage.
  Epigenetic inheritance relies on the precise recycling of parental histones during DNA replication. The N-terminal region of Pol1, the catalytic subunit of DNA polymerase &#x3b1;, has previously been implicated in chaperoning parental histone recycling. In thi…
  pubmed Dickinson Q, Karri S, Kenmogne OD, Zhu S 等 2026 置信度 0.82
• Synthetic sequence alignments as programmable probes of learned conformational landscapes in deep learning protein structure predictors.
  Proteins rely on conformational flexibility for biological function, yet predicting alternative states remains a major challenge in structural biology. Although deep learning models like AlphaFold2, AlphaFold3, and RoseTTAFold2 excel at static structure predic…
  pubmed Gut JA, Kleinschmidt N, Lemmin T 2026 置信度 0.82
• Engineered Mesenchymal Stem Cell-Derived Extracellular Vesicles as Antifibrotic Nanotherapeutics for Chronic Kidney Disease.
  Chronic kidney disease (CKD) affects more than 850 million people worldwide, and progressive renal fibrosis is the most common cause of irreversible renal loss. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are nanoscale membrane-bound particl…
  pubmed Zhang W, Xu S, Cao Z, Jin W 等 2026 Aug 11 置信度 0.82
• Author Correction: Engineered living glues secrete therapeutic proteins for treatment of inflammatory bowel disease.
  pubmed Ge C, Jiang S, Dong X, Jiang X 等 2026 置信度 0.82
• Logic-gated CARs: a unified framework for programmable cell-based delivery systems.
  Logic-gated chimeric antigen receptors (CARs) enable engineered immune cells to integrate multiple molecular and environmental inputs, improving therapeutic precision, safety, and resistance to antigen escape. As diverse logic-gated CAR architectures have emer…
  pubmed Wei PS, Ma Z, Chang E, Tsai YH 等 2026 Aug 11 置信度 0.82
• Engineered probiotics block arsenite absorption in the gastrointestinal tract.
  Chronic exposure to arsenite in food and water is a major global health concern, yet no practical strategies exist to prevent ingested arsenite from entering the body through the gastrointestinal tract. Here, we engineered Escherichia coli Nissle 1917 (EcN) to…
  pubmed Nguyen N, Wang M, Msibi SS, Kennedy V 等 2026 Aug 11 置信度 0.82
• Metabolic engineering of Candida yeasts for biotechnological applications.
  Candida yeasts represent a versatile yet underexploited platform for industrial biotechnology. These yeasts utilize a remarkably broad range of carbon sources, particularly for hydrophobic carbon sources, coupled with robust growth and diverse biosynthetic cap…
  pubmed Li XY, Wang Q, Zhang HM, Li K 等 2026 置信度 0.82
• Review: The African turquoise killifish as a model for the integrative physiology of vertebrate aging.
  With increasing emphasis on extending healthy lifespan, aging research requires vertebrate models that permit efficient mechanistic investigation and intervention testing within practical time and cost constraints. The African turquoise killifish (Nothobranchi…
  pubmed Wei Y, Tian J, Jin Y 2026 Aug 11 置信度 0.82
• A new method for the production of recombinant human Aβ(1-42) peptide.
  The amyloid-&#x3b2; protein (A&#x3b2;) plays a central role in the pathogenesis of Alzheimer's disease (AD). Chemically synthesized A&#x3b2;(1-42) is the most widely employed resource for AD mechanistic research and drug screening. However, solid-phase synthes…
  pubmed Chen P, Guo L, Guo X, Hong W 等 2026 Aug 11 置信度 0.82
• Targeted KRAS suppression in colorectal cancer via in vivo self-assembled siRNAs encapsulated in endogenous small extracellular vesicles.
  KRAS is a prevalent oncogenic driver whose therapeutic targeting has remained challenging beyond the G12C mutation. Here, we developed a gene circuit platform that enables the in vivo self-assembly of small extracellular vesicles (sEVs) encapsulating KRAS-spec…
  pubmed Sun Y, Zhao Y, Yang Y, Li Z 等 2026 Aug 11 置信度 0.82
• Biology-informed neural networks learn nonlinear representations from omics data to improve genomic prediction and biological discovery.
  Traditional genotype-to-phenotype models depend heavily on direct mappings that achieve only modest accuracy, forcing breeders to conduct large, costly field trials to maintain or marginally improve genetic gain. Models that incorporate intermediate molecular …
  pubmed Kontolati K, Gladstone RJ, Davis IW, Pickering EM 2026 Aug 置信度 0.82
• Reprogramming Plant Salt Tolerance: A Systems Biology Perspective on Algae-Derived Elicitors and Biostimulants.
  Soil salinisation poses a formidable threat to global agricultural productivity. It induces osmotic stress, ion toxicity and systemic oxidative damage in crops. Breeding salt-tolerant varieties is time-consuming. This creates an urgent need for rapid and susta…
  pubmed Li J, Sun H, Shi Y, Han J 等 2026 Aug 11 置信度 0.82
• Collective posterior inference from highly variable empirical replicates.
  High-throughput experimental platforms now routinely generate data from dozens or hundreds of independent observations. Simulation-based inference (SBI) offers a powerful framework for estimating model parameters from such complex datasets, but standard method…
  pubmed Ben Nun N, Rosset S, Gresham D, Ram Y 2026 Aug 置信度 0.82
• Protocol for isotype-resolved 3D imaging and quantification of bone marrow plasma cells in murine femurs.
  Bone marrow plasma cells maintain durable antibody responses, but their tissue localization and morphology are difficult to quantify in situ. Here, we present a protocol for isotype-resolved 3D imaging and quantification of bone marrow plasma cells in murine f…
  pubmed Camara A, Chen B, Xu AQ, Calado DP 2026 Aug 10 置信度 0.82
• Fluorinated Covalent Organic Framework Membranes for Pervaporation Desalination.
  Pervaporation membrane process, which involves liquid-vapor phase transition, holds great promise for high-salinity water desalination. The exploitation of advanced membrane materials and the active manipulation of water transport behavior within membrane nano…
  pubmed Hou J, Zhu Z, Bie M, Wu J 等 2026 Aug 11 置信度 0.82
• Repurposing a Small Molecule Plant Hormone as a Tunable ON-Switch for CAR-T Cell Immunotherapy.
  Precise regulation of chimeric antigen receptor (CAR)-T cell activity is essential to maximize efficacy and minimize toxicity. While switch-controlled CAR-T holds great promise, challenges remain in achieving accurate activation, reducing immunogenicity, and p…
  pubmed Zeng H, Zheng L, Tao R, Zheng S 等 2026 Aug 11 置信度 0.82
• Construction of cell factories, and multi-enzymatic and chemoenzymatic cascades to enable the efficient production of alkaloids.
  Covering: up to 2025Alkaloids constitute an invaluable reservoir for pharmaceutical discovery. However, their therapeutic development has long been constrained by the inefficiencies of plant extraction, as well as the economic impracticality of total chemical …
  pubmed Yuan Z, Liu H, Li F, Xiong Q 等 2026 置信度 0.82
• Sequential stenciling to reconstitute 2D microtissues for multicellular and synthetic signaling architectures.
  In mammalian organisms, native tissue function depends on precise spatial organization down to the cellular level. Reconstituting tissue architectures in 2D in vitro platforms can provide a means to study direct and indirect cell-cell interactions in a variety…
  pubmed Hirzel K, Čić J, Asmanidou S, Schmohl N 等 2026 Aug 11 置信度 0.82
• In Vitro-Selected DNA Aptamers Enable Detection of the Ancestral Peptide 3C8Y in [FeFe]-Hydrogenase CpI and in Metal-Rich, Acidic Environments: Implications for Astrobiology.
  Selecting molecular biosignatures of unequivocal biological origin and sufficient complexity is essential for developing next-generation biosensors in astrobiology-driven missions. Among the most promising candidates are ancestral peptides, molecular relics th…
  pubmed Blanco Y, Naskar S, Aguilera Á, Fernández-Algar M 等 2026 Aug 11 置信度 0.82
• The Expanding Reactivity of Cobamide-Containing Proteins: From Mechanistic Understanding to Non-native Biocatalysis.
  Cobamides are tetrapyrrole cofactors whose core structure, diverse axial ligands, and ability to access distinct redox states underpin the reactivity of a variety of enzymes, including isomerases, methyltransferases, and reductive dehalogenases. These enzymes …
  pubmed Kumar A, Lewis JC 2026 Jul 3 置信度 0.82
• Horseradish peroxidase as an electrochemical reporter protein for cell-free biosensors.
  Cell-free biosensor systems offer a promising platform for portable diagnostics. Here, we evaluate electrochemical readout from these systems, using horseradish peroxidase (HRP) as a redox enzyme reporter. HRP was synthesized in an Escherichia coli cell-free t…
  pubmed Ruhela A, Liyanagedera SBW, Laohakunakorn N, Marland JRK 2026 置信度 0.82
• Biomolecular Corona of Extracellular Vesicles: Report on Isev Workshop.
  The concept of the "biomolecular corona" (BC) was first introduced to describe the spontaneous absorption of molecules, mainly proteins, onto the surface of synthetic nanoparticles upon exposure to biological fluids. More recently, the same term has been used …
  pubmed Paolini L, Tassoni S, Al-Jamal KT, Banquy X 等 2026 Aug 置信度 0.82
• Genome-wide mapping of DCP2-dependent 5' cap footprints in Arabidopsis thaliana.
  Messenger RNA (mRNA) decapping mediated by DCP2 is a key mechanism controlling RNA stability and gene expression in eukaryotes, including plants. Despite its central role in regulating plant development and stress responses, the repertoire of mRNA 5' caps targ…
  pubmed Shukla N, Schon MA, Raxwal VK, Nodine MD 等 2026 Sep 置信度 0.82
• Differential sensitivity to strigolactone signaling and identification of putative D14/KAI2-like receptors in symbiotic Armillaria.
  Strigolactones (SLs) are carotenoid-derived signaling molecules that play essential roles in plant development and rhizosphere communication, particularly in the establishment of beneficial plant-fungus interactions. Although SL-mediated signaling has been ext…
  pubmed Wu D, Zhang C, Cheng Y, Wen H 等 2026 置信度 0.82
• Community matters: stress tolerance and survival of Bacillus subtilis and Staphylococcus capitis in a synthetic space habitat consortium.
  Conventional microbiological methods typically examine isolated bacterial species, which limits the insight into how microorganisms behave in more realistic, complex ecosystems. In contrast, synthetic bacterial consortia offer a practical and ecologically mean…
  pubmed Krämer CL, Ly-Sauerbrey Y, Maier M, Kadler L 等 2026 置信度 0.82
• Meeting report: 400 synthetic biology projects promote sustainable development.
  The 21st annual International Genetically Engineered Machine (iGEM) Grand Jamboree took place on the 23rd to 26th of October 2024 at the Paris Expo in Paris, France. It was the final event of the year-long iGEM Competition in microbial synthetic biology, at wh…
  pubmed Daumiller D, de Ancos Jimeno C, Gaudiesius A, Lam EHT 等 2025 置信度 0.82