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3',3'-cyclic diguanylate (cyclic di-GMP) and alternative cyclic di- and oligonucleotides are ancient highly conserved signaling molecules of bacteria and archaea, which can be present in metazoans up to humans. Their impact in fundamental behavioral modes and …
pubmed
Römling U
2025
置信度 0.82
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Most synthetic reactions occur in homogeneous phases, where the electron orbitals of reactants are embedded in uniform chemical environments and experience symmetric electronic regulation. In contrast, heterogeneous interfaces ( e.g. , liquid/solid, gas/solid,…
pubmed
Chen C, Normurodova K, Bozorov N, Maan AA 等
2026 Aug 11
置信度 0.82
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Differences among individuals in susceptibility to adverse drug reactions are strongly influenced by genetic variation affecting drug metabolism, transport, immune response, and pharmacodynamics pathways, presenting both challenges and opportunities for drug d…
pubmed
Pavlova N, Kaloudas D, Traykovska M, Penchovsky R
2026 Jul 30
置信度 0.82
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Leptospirosis, caused by pathogenic species of the gram-negative spirochete called Leptospira spp., is one of the most serious zoonotic diseases in the world. This disease commonly affects impoverished or underdeveloped populations with no proper sanitary cond…
pubmed
Couto CAP, Ferreira LC, Ribeiro AJ, Silva KA 等
2026 Jul 28
置信度 0.82
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Neuroinflammation is a major complex reaction that causes Neurodegenerative Diseases (ND) and cognitive behavioural disorders such as Alzheimer's Disease (AD), Parkinson's disease, multiple sclerosis, and traumatic brain injury. Neuroinflammation can be regula…
pubmed
Shakya M, Patel SK, Singh M, Rao H 等
2026 Jul 28
置信度 0.82
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pubmed
Zhao C, Cai S, Shi R, Li X 等
2026 Aug 10
置信度 0.82
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pubmed
Shi Z, Xu Z, Rong W, Sun H 等
2026
置信度 0.82
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Hydrogen sulfide (H 2 S) is widely implicated in plants' adaptive responses to salinity, regulating processes ranging from ionic homeostasis to antioxidant defense and is often described as a central signaling hub due to its interaction with core signaling pat…
pubmed
Ijaz U, Khan WUD, Wang L, Corpas FJ 等
2026 Aug 10
置信度 0.82
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Anaerobic membrane bioreactors (AnMBRs) treating brewery wastewater face bottlenecks of acid inhibition and membrane fouling. In this study, AnMBR with iron-modified biochar (Fe-BC) in-situ addition (FeBC-AnMBR) and conventional AnMBR (C-AnMBR) were compared t…
pubmed
Li X, Song Z, Wang Y, Du Q 等
2026 Aug 10
置信度 0.82
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Abnormal accumulation of β-amyloid protein (Aβ) in the brain is considered as the primary hallmark of Alzheimer's disease (AD). Beyond inducing neuronal metabolic disorders and apoptosis, Aβ activates oxidative stress pathways, thereby exacer…
pubmed
Lin X, Wei Z, Dong X, Sun Y
2026
置信度 0.82
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Since the identification of PARP1/2 as synthetic lethal targets in BRCA-deficient breast cancer and the subsequent approval of catalytic domain-targeting PARP inhibitors, the landscape of PARP inhibitors has expanded to encompass a broader chemical tool kit. B…
pubmed
Owens MC, Leung AKL
2026 Aug 10
置信度 0.82
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Liver-on-a-chip (LOC) systems are tunable, microscale environments that can incorporate additional layers of physiologic complexity in comparison to 2D cell culture. LOCs are an in vitro adjunct and potential alternative to in vivo animal models that utilize h…
pubmed
Brooks NM, Peczak A, Schwartz RE
2026 Aug 10
置信度 0.82
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Influenza viruses belong to the Orthomyxoviridae family, they are categorized into four types: A, B, C, and D. Influenza B viruses co-circulate annually with influenza A strains during seasonal flu epidemics in humans, causing severe disease. The segmented RNA…
pubmed
Thirion M, Stelfox AJ, Chenavier F, Chomat H 等
2026 Aug
置信度 0.82
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Chronic inflammatory disorders represent a major global health burden characterized by persistent immune activation, oxidative stress, and progressive tissue dysfunction. Dysregulated redox signaling has positioned the Kelch-like ECH-associated protein 1 (KEAP…
pubmed
Shadab A
2026 Aug 10
置信度 0.82
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Biomolecular condensates formed through phase separation have emerged as a central principle of cellular organization, enabling the dynamic regulation of gene expression, signaling, metabolism, and stress responses. While early conceptual advances in condensat…
pubmed
Peng J, Agudo-Canalejo J, Chodasiewicz M, Van Damme D 等
2026
置信度 0.82
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Epigenetic regulation plays a central role in metabolic gene expression in eukaryotes. Focusing on Saccharomyces cerevisiae as a model, this review systematically examines how histone modifications, including acetylation, methylation, phosphorylation, ubiquiti…
pubmed
Chen Y, Liu Q, Liu K, Wu C 等
2026 Aug 10
置信度 0.82
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Despite significant advancements in drug development and discovery, tuberculosis remains one of the world's deadliest infectious diseases. The rise and global spread of multidrug-resistant strains underscore a critical need for new antibiotics with distinct me…
pubmed
Fries F, Herrmann J, Dal Molin M, Wormser Y 等
2026 Aug 10
置信度 0.82
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Elastin-like polypeptides (ELPs) are versatile biopolymers for constructing synthetic cell membranes. Applications in biosynthesis, molecular secretion, and payload delivery require an understanding of the solute transport across ELP membranes. In this work, w…
pubmed
Mao J, Xi Y, Liu AP, Ferguson AL
2026 Aug 10
置信度 0.82
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RNA phages are attractive platforms for the design of programmable bioparticles, but their development has been constrained by limited knowledge of genomic sites that can tolerate sequence insertion. Here, we combined MuA transposase-mediated in vitro insertio…
pubmed
Choi S-Y, Kim M-J, Kwon OH, Park C 等
2026 Aug 10
置信度 0.82
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It has been suggested that the hemagglutinin of the human-infecting cattle-derived 2.3.4.4b virus A/Texas/34 H5N1 (H5TX) requires only one mutation, namely Q226L, to switch from binding avian-type to human-type receptor preference. In this study, we examined t…
pubmed
Ríos Carrasco M, Guerreiro Cabana MF, Kovács E, Ducarne Z 等
2026 Aug 10
置信度 0.82
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Spatiotemporal control over cell fate and behavior within bioprinted constructs remains a key challenge in tissue engineering. Optogenetics offers versatile potential for non-invasive regulation of biological processes. Yet, its integration within large-scale,…
pubmed
Ribezzi D, Català P, Größbacher G, Bernal PN 等
2026 Aug 10
置信度 0.82
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Aminoacyl-tRNA synthetases (AARSs) safeguard translational fidelity by coordinating amino acid activation and tRNA charging within distinct catalytic and editing domains. In leucyl-tRNA synthetase (LeuRS), the small, centrally located zinc-binding domain (ZN d…
pubmed
Hoffmann G, Dulić M, Gruic-Sovulj I, Palencia A
2026 Aug 10
置信度 0.82
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To support dual-carbon goals and address the limitations of conventional CO 2 valorization technologies, this review summarizes recent advances in electrochemical-biological coupling systems for high-value CO 2 utilization, with emphasis on catalytic fundament…
pubmed
Shi X, Li C, Guo F, Jing Y 等
2026
置信度 0.82
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Recombinant measles virus (rMeV) vectors are promising platforms for vaccine development against emerging infectious diseases due to their safety, stability, and potent immunogenicity. However, conventional rMeV rescue systems frequently exhibit low efficiency…
pubmed
Ma Z, Wang W, Lou Q, Jiang H 等
2027 Mar
置信度 0.82
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Communication via aggregation pheromones is responsible for the behavioural and ecological characteristics of many species of weevils (Coleoptera). In insects, pheromones are detected by specialized odorant receptors (ORs), called pheromone receptors (PRs), wh…
pubmed
Zhang S, Montagné N, Antony B, Wang G 等
2026 Aug
置信度 0.82
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Ethanol stress is a major limiting factor affecting yeast performance and ethanol yield in alcoholic beverages and bioethanol industrial fermentation. This study revealed that wheat gluten peptide trileucine supplementation enhanced the ethanol stress toleranc…
pubmed
Jin X, Li L, Shao M, Ding J 等
2026 Aug 9
置信度 0.82
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Actinoplanes teichomyceticus is a well-established producer of bioactive secondary metabolites, including the glycopeptide antibiotic teicoplanin. Although its antibiotic biosynthetic capacity has been extensively investigated, its siderophore diversity and an…
pubmed
Oyedele AS, Jana S, Jeon K, Vazrala N 等
2026 Aug 14
置信度 0.82
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The increasing incidence of diseases resulting from fungal infections is due to the high morbidity and mortality associated with these microorganisms. Sinapic acid is a plant-derived phenolic compound with antifungal activity. Therefore, in this study, a colle…
pubmed
Ferreira FES, Emídio JJ, de Sá ÉRA, Barros RO 等
2026 Aug
置信度 0.82
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Selective therapeutic gene activation in tumors remains challenging because tumor-enriched promoters often exhibit basal activity in non-target cells and may not fully capture intratumoral heterogeneity. In addition, direct promoter-driven expression of cytoto…
pubmed
Zhang X, Cao C, Huang Z, Wu D 等
2026 Aug 8
置信度 0.82
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Open surgical repair with replacement of the diseased segment by a synthetic Dacron graft remains the standard treatment for ascending thoracic aortic aneurysms and dissections. However, post-operative sequelae, including dissection of the descending aorta (DA…
pubmed
Ianniruberto I, Astori D, Saitta S, Milesi D 等
2026 Aug 8
置信度 0.82
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The growing industrial demand for economically attractive large-scale bioprocesses has increased the need for reliable and computationally feasible modelling approaches. Gas fermentation plays a particular role as the targeted commodities ask for large-scale s…
pubmed
Link C, Puiman L, Takors R
2026 Aug 8
置信度 0.82
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With broad-spectrum, low resistance, and multifunctional properties, antimicrobial peptides (AMPs) are promising therapeutic agents against drug-resistant pathogens, yet their discovery and optimization still remain challenging due to the complexity of sequenc…
pubmed
Liu Y, Hu J, Zhang N, Bai Y 等
2027
置信度 0.82
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Efficient wastewater recycling technologies are essential for long-duration space missions and sustainable water management on Earth. Here, a bioelectrochemical system integrating Proteus mirabilis with a platinum-nickel-modified boron-doped diamond electrode …
pubmed
Omoogun A, De La O G, Chatterjee S, Prieto Gómez LJ 等
2026 Aug 4
置信度 0.82
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G-quadruplexes (G4s) are noncanonical nucleic acid structures involved in the regulation of key biological processes and represent attractive targets for therapeutic intervention. In this study, we report the design, synthesis, and biophysical evaluation of a …
pubmed
Fracchioni G, Caramiello AM, Nadai M, Lena A 等
2026 Aug 4
置信度 0.82
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Programmable materials integrated with intelligent signal processing are essential for developing adaptive and autonomous environmental sensing systems. Here, we present a biohybrid material platform in which environmental DNA is captured by streptavidin (SA)-…
pubmed
He H, Wei TY, Ruder WC
2026 Aug 4
置信度 0.82
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India is at a stage where the economy is rapidly expanding with bioeconomy emerging as a significant contributor to national growth and is being supported by the government through targeted missions and strategic policy interventions. Landmark initiatives such…
pubmed
Gupta S, Kumar J
2026 Jan-Dec
置信度 0.82
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Antimicrobial peptides (AMPs) are emerging as promising candidates for developing novel antibiotics in response to the growing threat of antimicrobial resistance (AMR). These naturally occurring molecules, found across diverse organisms, play a crucial role in…
pubmed
Raka V, Nandanwar H
2026 Aug
置信度 0.82
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To our knowledge, direct detection of foodborne bacterial pathogens using toehold biosensors has not been demonstrated in complex food matrices such as raw milk, particularly for Listeria monocytogenes . Here, we report the design and evaluation of toehold bio…
pubmed
Carballo-Uicab VM, Casados-Vázquez LE, Endy D, Barboza-Corona JE
2026
置信度 0.82
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The M13 filamentous bacteriophage has transcended its origins as a model for viral replication to become a premier programmable bio-scaffold at the intersection of nanotechnology, synthetic biology and clinical medicine. While famously known for the Nobel Priz…
pubmed
Passaretti P, Stokes K, Carter J, Sun Y 等
2026 Aug 7
置信度 0.82
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Growing environmental concerns about conventional plastics have created a demand for alternative resources that are both truly biodegradable and cost-effective. Microbial Polyhydroxyalkanoates (PHAs) are drawing great attention due to their degradability and l…
pubmed
Mohanrasu K, SelvaKumar R, Grainge I, Arun CM 等
2026 Aug 7
置信度 0.82
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Tsampa (Zanba), a roasted highland barley flour staple in Chinese Tibetan diets, contains higher protein and lysine content than most cereals. Despite its nutritional significance, the digestion kinetics of tsampa proteins and bioactivity of resultant peptides…
pubmed
Chen C, Wang J, Jiang J, Puba Z 等
2026
置信度 0.82
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Mitochondria are the primary arbiters of cellular redox homeostasis, bioenergetic flux, and programmed cell death. Their dysfunction, characterized by excessive reactive oxygen species (ROS) production, impaired oxidative phosphorylation (OXPHOS), and collapse…
pubmed
Awasthi V, Lalu E, Saaoud F, Das A 等
2026 Aug 4
置信度 0.82
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Extending community detection from pairwise networks to hypergraphs introduces fundamental theoretical challenges. Hypergraphs exhibit structural heterogeneity with no direct graph analog: Hyperedges of varying orders can connect nodes across communities in di…
pubmed
Li J, Schaub MT, Peel L
2026 Aug 7
置信度 0.82
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Understanding how living organisms process sensory information from their surroundings and translate it into decisions is a fundamental problem across biological scales - from biochemical signalling in single-cells to neural computations in animal brains. In t…
pubmed
Nicoletti G, Celani A
2026 Aug
置信度 0.82
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Synthetic biology involves combining different DNA fragments, each containing functional biological parts, to address specific problems. Fundamental gene-function research often requires cloning and propagating DNA fragments, such as those from the iGEM Parts …
pubmed
Pereira H, Silva PC, Davis MW, Abraham L 等
2026
置信度 0.82
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Rhizobacteria play a central role in supporting plant growth, contributing to nutrient acquisition, stress tolerance and disease suppression. Harnessing and improving rhizosphere microbial communities therefore represents a promising avenue towards more sustai…
pubmed
Garcia-Perez E, Perrin L, Malone JG, Thompson CMA 等
2026
置信度 0.82
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Plant viruses continue to impose severe constraints on global agriculture, often leading to substantial yield and economic losses. Conventional management strategies such as vector control and resistance breeding frequently fail to provide durable and broad-sp…
pubmed
Bharathi S K, S H, G K, J A 等
2026 Aug 7
置信度 0.82
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Escherichia coli remains the premier microbial chassis in industrial biotechnology; yet, translating laboratory-scale metabolic successes into robust, hundred-ton-scale manufacturing presents persistent multidimensional bottlenecks. This review systematically …
pubmed
Luan H, Qiu W, Yang R, Feng K 等
2026
置信度 0.82
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Microbial lipases are versatile biocatalysts with high catalytic efficiency, substrate specificity, stability, and ability to catalyze a wide range of processes under mild environmental conditions, which make them highly valuable in various industrial and biot…
pubmed
Priti K, Chandra H, Sagar K
2026 Aug 7
置信度 0.82
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Polymyxins are often last-resort antibiotics against high-priority Gram-negative pathogens, particularly Acinetobacter baumannii . However, most mechanistic studies to date have overlooked the heterogeneity within bacterial populations during polymyxin treatme…
pubmed
Han M-L, Kho ZY, Wang X, Zhao J 等
2026 Aug 7
置信度 0.82
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Circular RNAs (circRNAs) have recently been shown to possess coding potential via a cap-independent translation mechanism, challenging their traditional classification as noncoding RNAs and implicating it directly in the pathogenesis of various diseases. Despi…
pubmed
Zhao S, Yu B, Liu L
2026 Jan-Dec
置信度 0.82
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Correction for 'Antibacterial drug discovery: challenges and preclinical promises from synthetic small molecules' by Guilherme F. S. Fernandes et al. , Chem. Soc. Rev. , 2026, 55 , 7853-7932, https://doi.org/10.1039/d5cs00617a.
pubmed
Fernandes GFS, Kim SH, Dos Santos JL, Wang Y 等
2026
置信度 0.82
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Potato ( Solanum tuberosum ) is critical for global food security. However, potato production is severely constrained by two major pests, potato tuber moth ( Phthorimaea operculella , PTM) and Colorado potato beetle ( Leptinotarsa decemlineata , CPB), which ca…
pubmed
Yang D, Lin W, Yang Z, Zhou D 等
2026 Dec
置信度 0.82
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A series of sulfonic acid-functionalized plugged and unplugged bifunctional periodic mesoporous organosilicas incorporating either ethyl-imidazolium or phenyl-imidazolium bridging units (P/U BFPMO-IL-PrSO 3 Hs, including Et-U-BFPMO-IL-PrSO 3 H (1a), Et-P-BFPMO…
pubmed
Moradi H, Maleki Y, Ganji N, Pourshiani O 等
2026 Aug 25
置信度 0.82
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Nucleic acid synthesis is a dual-use technology that can benefit fields such as biology, medicine, and information storage. However, synthetic nucleic acids could also potentially be used negligently and ultimately cause harm, or be used with malicious intent …
pubmed
Laird TS, Flyangolts K, Bartling C, Gemler BT 等
2026 Sep
置信度 0.82
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Cancer is a complex disease driven by genetic, metabolic, and environmental alterations, whose investigation is often constrained by the limited tractability of mammalian systems. The budding yeast Saccharomyces cerevisiae has emerged as a powerful eukaryotic …
pubmed
Assalve G, Lunetti P, Fai A, Frattaruolo L 等
2026
置信度 0.82
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Polymerase cycling assembly (PCA) allows gene synthesis from the assembly of overlapping oligonucleotides. For optimal yield, the sets of overlapping fragments should present uniform hybridization temperatures and minimal spurious dimer formation, conditions t…
pubmed
Luna-Cerralbo D, Serrano A, Hamdan F, Martínez-Oliván J 等
2026
置信度 0.82
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Plant-associated biocontrol bacteria play a pivotal role in advancing sustainable agriculture by minimizing the reliance on toxic chemical pesticides. The order Burkholderiales is an underexplored yet highly promising group of microorganisms, characterized by …
pubmed
Luo X, Huang X, Cao H, Bai X 等
2026
置信度 0.82
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Surface layer (S-layer) lattices, composed of proteins and glycoproteins, constitute one of the most abundant and conserved supramolecular structures in the prokaryotic world. These self-assembling, two-dimensional arrays represent a major evolutionary investm…
pubmed
Sleytr UB, Schuster B
2026
置信度 0.82
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Superconserved receptors expressed in brain (SREB) are a family of orphan G protein-coupled receptors with 3 members in most vertebrates (GPR27 or SREB1, GPR85 or SREB2, and GPR173 or SREB3). They are associated with diverse physiological processes, ranging fr…
pubmed
Heyder CF, Murray CA, Granith P, Makhkamov M 等
2026 Aug 3
置信度 0.82
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The leaf surface, or phyllosphere, hosts abundant and diverse bacterial communities that interact with both the host plant and herbivorous insects, yet their collective influence on plant-insect interactions remains poorly investigated. We established a functi…
pubmed
Müller M, Huve MAP, Kunzler M, Remus-Emsermann MNP 等
2026
置信度 0.82
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A comprehensive and scalable understanding of human drug metabolism is essential for advancing pharmacology, toxicology, and precision medicine. Traditional in-vitro models, such as human liver microsomes and purified enzyme systems, are often constrained by h…
pubmed
Durairaj P
2026
置信度 0.82
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Clear cell renal cell carcinoma exhibits striking intra-tumoral heterogeneity at morphological and genetic levels, complicating treatment and contributing to disease progression. CcRCCs with rhabdoid differentiation are highly aggressive tumors characterized b…
pubmed
Bolck HA, Migh E, Kriston A, Zajac N 等
2026 Aug 6
置信度 0.82
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Current on-site arsenic monitoring is hindered by cold-chain dependence and biosafety risks. We developed a field-deployable cell-free protein synthesis (CFPS) biosensor for the rapid, selective detection of toxic inorganic arsenic in seaweed matrices (Sargass…
pubmed
Jeong DS, Kim T, Cha M, Lee H 等
2026 Oct 1
置信度 0.82
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Fermented Spirulina has superior sensorial and bioactive properties, but the impact of microbial succession on metabolic regulations of these attributes remains unclear. This study investigates metabolic regulations via integrated multi-omics analyses that lin…
pubmed
Su K, Shahid A, Shi B, Zhao A 等
2026 Aug 1
置信度 0.82
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Based on the tumor Warburg effect and the strategy of GLUT-mediated drug transport, we have successfully discovered a promising molecular glue immunomodulatory drug (IMiD) candidate that exhibits excellent dual-targeting capability in tumor selective drug upta…
pubmed
Jia M, Zhang R, Liu Y, Gao X 等
2026
置信度 0.82
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The generation of functional viral genomes has urgent biosafety and biosecurity implications.
pubmed
Inglesby TV, Hanke MS
2026 Aug 6
置信度 0.82
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Many important biological functions arise not from single genes but from complex interactions encoded by entire genomes. We report the first generative design of complete bacteriophage genomes using genome language models. We generated viable bacteriophages wi…
pubmed
King SH, Driscoll CL, Li DB, Guo D 等
2026 Aug 6
置信度 0.82
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pubmed
Larracuente AM, Gould F, Dyer KA
2026 Aug 5
置信度 0.82
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Version 4.0: This update primarily cleaned up the prior versions. The preprint is now ready for journal submission. A graphical abstract has been added. ABSTRACT An active debate exists over the safety of synthetic biology and other advanced research tools use…
datacite
Massey, Steven, Quay, Steven Carl
2026
置信度 0.66
BiosecuritySARS-CoV-2Biosafety
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Version 4.0: This update primarily cleaned up the prior versions. The preprint is now ready for journal submission. A graphical abstract has been added. ABSTRACT An active debate exists over the safety of synthetic biology and other advanced research tools use…
datacite
Massey, Steven, Quay, Steven Carl
2026
置信度 0.66
BiosecuritySARS-CoV-2Biosafety
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This dataset contains GROQ-seq functional measurements of LacI, RamR, and VanR transcription factor variant libraries (SSVL, epPCR, and SS) assayed against their cognate wild-type operator sequences. This run of the assay was performed at the Design, Automatio…
datacite
Cortade, Dana, McLellan, James, Baranowski, Catherine, Reider Apel, Amanda 等
2026
置信度 0.66
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This dataset contains GROQ-seq functional measurements of LacI, RamR, and VanR transcription factor variant libraries (SSVL, epPCR, and SS) assayed against their cognate wild-type operator sequences. This run of the assay was performed at the Design, Automatio…
datacite
Cortade, Dana, McLellan, James, Baranowski, Catherine, Reider Apel, Amanda 等
2026
置信度 0.66
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The “Magnificent Seven” label began as a market nickname, but it now names a structural problem in contemporary capitalism: seven technology linked firms became so profitable, cash rich, index heavy, and strategically central that their future can no longer be…
datacite
Zeshan, Sultan
2026
置信度 0.66
Magnificent Sevenmarket concentrationArtificial intelligenceArtificial IntelligenceArtificial Intelligence/economics
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The “Magnificent Seven” label began as a market nickname, but it now names a structural problem in contemporary capitalism: seven technology linked firms became so profitable, cash rich, index heavy, and strategically central that their future can no longer be…
datacite
Zeshan, Sultan
2026
置信度 0.66
Magnificent Sevenmarket concentrationArtificial intelligenceArtificial IntelligenceArtificial Intelligence/economics
-
datacite
All Sciences Academy
2026
置信度 0.66
-
datacite
All Sciences Academy
2026
置信度 0.66
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This repository contains the theoretical framework, mathematical models, and simulation scripts for investigating metabolic aging inside bottom-up minimal synthetic cells. Natural metabolic aging is highly confounded by organismal physiology, but this work eng…
datacite
Sandler, Leon
2026
置信度 0.66
SpudCellSynthetic biologyProtocell engineeringHomochiralityMolecular scaffold
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This repository contains the theoretical framework, mathematical models, and simulation scripts for investigating metabolic aging inside bottom-up minimal synthetic cells. Natural metabolic aging is highly confounded by organismal physiology, but this work eng…
datacite
Sandler, Leon
2026
置信度 0.66
SpudCellSynthetic biologyProtocell engineeringHomochiralityMolecular scaffold
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The ubiquitous cheminformatics tools and practices of today all evolved out of an industry that centered around drug-like small organic molecules as their first and usually only consideration, leaving any other kind of molecular entity as an afterthought. The …
datacite
Clark, Alex
2026
置信度 0.66
chemistrycheminformaticsbioinformatics
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The ubiquitous cheminformatics tools and practices of today all evolved out of an industry that centered around drug-like small organic molecules as their first and usually only consideration, leaving any other kind of molecular entity as an afterthought. The …
datacite
Clark, Alex
2026
置信度 0.66
chemistrycheminformaticsbioinformatics
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Opzione 1: Focus sulla Teoria Matematica Generale Italiano Titolo: Scoperta Scientifica Automatizzata Multi-Teoria: Estrazione di Aggiunzioni di Galois e Reticoli di Meet/Join da Geometrie di Ipergrafi Universali Descrizione (Abstract): Questo lavoro presenta …
datacite
Usai, Luigi
2026
置信度 0.66
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Opzione 1: Focus sulla Teoria Matematica Generale Italiano Titolo: Scoperta Scientifica Automatizzata Multi-Teoria: Estrazione di Aggiunzioni di Galois e Reticoli di Meet/Join da Geometrie di Ipergrafi Universali Descrizione (Abstract): Questo lavoro presenta …
datacite
Usai, Luigi
2026
置信度 0.66
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Walkthrough: Piattaforma Computazionale Biofisica Braarudosphaera bigelowii (v2.2.0) Il rilascio v2.2.0 (Zenodo DOI: 10.5281/zenodo.21844715) completa il passaggio architetturale ed epistemologico del software Braarudosphaera bigelowii a Piattaforma Computazio…
datacite
Usai, Luigi
2026
置信度 0.66
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Walkthrough: Piattaforma Computazionale Biofisica Braarudosphaera bigelowii (v2.2.0) Il rilascio v2.2.0 (Zenodo DOI: 10.5281/zenodo.21844715) completa il passaggio architetturale ed epistemologico del software Braarudosphaera bigelowii a Piattaforma Computazio…
datacite
Usai, Luigi
2026
置信度 0.66
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This working paper proposes the concept of recursive catastrophic technology shocks: repeated episodes in which scientific progress generates transformative technologies whose capability amplification exceeds the governance capacity available at the time of em…
datacite
Trinity Labo
2026
置信度 0.66
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This working paper proposes the concept of recursive catastrophic technology shocks: repeated episodes in which scientific progress generates transformative technologies whose capability amplification exceeds the governance capacity available at the time of em…
datacite
Trinity Labo
2026
置信度 0.66
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RENASCENT-Q Theory v.40 presents a geometric framework in which negentropic coherence is proposed as a fifth fundamental force. The theory is grounded in the Federico Maya Eternity Theorem, which establishes that the dilatonic operator on a compact 12-dimensio…
datacite
Federico Maya
2026
置信度 0.66
Riemann HypothesisHilbert–Pólya operatoressential self-adjointnessThe Federico Maya Eternity Theorem
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Methods paper on Mermaid flowcharts for perturbation design, using the E. coli lac operon as a worked example. Primary document: PDF (figures embedded). Version 1.6 (June 28, 2026): PDF-only deposit for clarity; Markdown source remains on GitHub. Includes Voig…
datacite
Welz, Gary
2026
置信度 0.66
Mermaid, diagrams-as-code, gene regulatory networks, perturbation design, lac operon, RegulonDB, Boolean logic, large language models, systems biology, E. coli
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Methods paper on Mermaid flowcharts for perturbation design, using the E. coli lac operon as a worked example of layered hybridization between literature logic and RegulonDB-class facts. Version 1.3 (June 28, 2026): Replaces raw Mermaid code blocks in the Mark…
datacite
Welz, Gary
2026
置信度 0.66
Mermaid, diagrams-as-code, gene regulatory networks, perturbation design, lac operon, RegulonDB, Boolean logic, large language models, systems biology, E. coli
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THE MARKET OF LIFE Legal and Economic Framework for Designed Organisms in the Age of Synthetic Biology and Artificial Intelligence
datacite
elrakhawi, mohamed kamal arafa
2026
置信度 0.66
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THE MARKET OF LIFE Legal and Economic Framework for Designed Organisms in the Age of Synthetic Biology and Artificial Intelligence
datacite
elrakhawi, mohamed kamal arafa
2026
置信度 0.66
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ABSTRACT Background: Major AI companies and the pharmaceutical industry are developing AI-based drug discovery models largely focused on hyper-fast data analysis of medicinal chemistry, synthetic biology, biotechnology, and recombinant DNA from which to genera…
datacite
Howard Friel
2026
置信度 0.66
MOA StackClaude Sonnet 4.6Human-in-the-Loop AIAI in Drug DiscoveryPediatric and Adult Oncology
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ABSTRACT Background: Major AI companies and the pharmaceutical industry are developing AI-based drug discovery models largely focused on hyper-fast data analysis of medicinal chemistry, synthetic biology, biotechnology, and recombinant DNA from which to genera…
datacite
Howard Friel
2026
置信度 0.66
MOA StackClaude Sonnet 4.6Human-in-the-Loop AIAI in Drug DiscoveryPediatric and Adult Oncology
-
Title: Hybrid Evolutionary Bridge Author: Pruthwi Gawhande What it is: A theoretical framework in synthetic biology called the Bridge-Genome Platform — a proposed modular synthetic chromosome system (SHC-1) that could theoretically enable the creation of stabl…
datacite
Gawhande, Pruthwi
2026
置信度 0.66
Genetic engineeringMolecular geneticsHybridization, Genetic/geneticsSynthetic biologyBiogeochemistry
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Title: Hybrid Evolutionary Bridge Author: Pruthwi Gawhande What it is: A theoretical framework in synthetic biology called the Bridge-Genome Platform — a proposed modular synthetic chromosome system (SHC-1) that could theoretically enable the creation of stabl…
datacite
Gawhande, Pruthwi
2026
置信度 0.66
Genetic engineeringMolecular geneticsHybridization, Genetic/geneticsSynthetic biologyBiogeochemistry
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Processed data and reproducibility resources for Bottini et al. (2026) This Zenodo repository contains the dataset-specific scratch folders required to reproduce the bioinformatic analyses presented in Bottini et al. (2026). The folders preserve the directory …
datacite
Sveva Bottini, Francesca, Amodeo, Romano, Alberto, De Gregorio, Mario 等
2026
置信度 0.66
-
Processed data and reproducibility resources for Bottini et al. (2026) This Zenodo repository contains the dataset-specific scratch folders required to reproduce the bioinformatic analyses presented in Bottini et al. (2026). The folders preserve the directory …
datacite
Sveva Bottini, Francesca, Amodeo, Romano, Alberto, De Gregorio, Mario 等
2026
置信度 0.66
-
FDTBX - Computational Tools for Simulation of X-ray Fiber Diffraction Patterns from Atomic Coordinates. V2.1.0 - 24th of August 2026. ABOUT fdtbx is an open-source Python module for simulating X-ray fiber diffraction patterns from atomic coordinate models. Fib…
datacite
Sikorski, Pawel
2026
置信度 0.66
fiber diffractionCrystallographyPolymer sciencesCondensed matter physicsMolecular Structure
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FDTBX - Computational Tools for Simulation of X-ray Fiber Diffraction Patterns from Atomic Coordinates. V2.1.0 - 24th of August 2026. ABOUT fdtbx is an open-source Python module for simulating X-ray fiber diffraction patterns from atomic coordinate models. Fib…
datacite
Sikorski, Pawel
2026
置信度 0.66
fiber diffractionCrystallographyPolymer sciencesCondensed matter physicsMolecular Structure