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Abstract In commercial artificial vision system (AVS), the sensing, storage, and computing units are usually physically separated due to their architecture and performance gaps, which thus increases the volume, complexity, and energy loss. This work develops a…
openalex
Tu Zhao, Wenbo Yue, Qunrui Deng, Wenjie Chen 等
2025-04-15
置信度 0.72
Neuromorphic engineeringTransistorResponsivityMaterials scienceComputer science
-
The SIGnaling Network Open Resource (SIGNOR 4.0, https://signor.uniroma2.it) is a database of manually curated causal interactions between biological entities. These signaling events are annotated along with their effect-denoting the activation or inactivation…
openalex
Prisca Lo Surdo, Marta Iannuccelli, Klas Karis, Eleonora Meo 等
2025-11-17
置信度 0.72
Interface (matter)Data curationBiologyFocus (optics)Mechanism (biology)
-
The field of microbiome research has evolved rapidly over the past few decades and has become a topic of great scientific and public interest. As a result of this rapid growth in interest covering different fields, we are lacking a clear commonly agreed defini…
openalex
Gabriele Berg, Daria Rybakova, Doreen Fischer, Tomislav Cernava 等
2020-06-30
置信度 0.72
BiologyMicrobiomeMicrobial ecologyMedical microbiologyComputational biology
-
Abstract Neuromorphic computing is a budding avenue though it has been known since the 80’s. The extensive research and development in the field of artificial intelligence particularly in the last decade is tremendous. The growth of artificial intelligence is …
openalex
R Vishwa, R. Karthikeyan, R Rohith, A Sabaresh
2020-08-01
置信度 0.72
Neuromorphic engineeringComputer scienceIBMField (mathematics)Artificial intelligence
-
Abstract Pancreatic ductal adenocarcinoma (PDAC) is lethal in 88% of patients 1 , yet harbours mutation-derived T cell neoantigens that are suitable for vaccines 2,3 . Here in a phase I trial of adjuvant autogene cevumeran, an individualized neoantigen vaccine…
openalex
Luis A. Rojas, Zachary Sethna, Kevin C. Soares, Cristina Olcese 等
2023-05-10
置信度 0.72
MedicineT cellCD8ImmunologyPancreatic cancer
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Abstract. Ocean alkalinity enhancement (OAE), one of the marine carbon dioxide removal strategies, is gaining recognition in its ability to mitigate climate change and ocean acidification (OA). OAE is based on adding alkalinity to open-ocean and coastal marine…
openalex
Nina Bednaršek, Hanna van de Mortel, Greg Pelletier, Marisol García‐Reyes 等
2025-01-28
置信度 0.72
AlkalinityIdentification (biology)Environmental scienceSensitivity (control systems)Oceanography
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Biological materials have outstanding properties. With ease, challenging mechanical, optical or electrical properties are realised from comparatively `humble' building blocks. The key strategy to realise these properties is through extensive hierarchical struc…
openalex
Tilman A. Grünewald, Marianne Liebi, Henrik Birkedal
2024-08-23
置信度 0.72
StructuringCharacterization (materials science)Computer scienceScale (ratio)Biological materials
-
As of today, the fifth generation (5G) mobile communication system has been rolled out in many countries and the number of 5G subscribers already reaches a very large scale. It is time for academia and industry to shift their attention towards the next generat…
openalex
Wei Jiang, Bin Han, Mohammad Asif Habibi, Hans Dieter Schotten
2021-01-01
置信度 0.72
Key (lock)Set (abstract data type)TelecommunicationsOpen researchComputer science
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Abstract As one of the key components for brain‐inspired computing, optoelectrical synapses based on memory devices are capturing growing attention due to their integrated function of sense and memory. However, the high power consumption (large programming vol…
openalex
Jiang Zeng, Lin Hu, Yuan Pan, Zibin Huang 等
2025-05-06
置信度 0.72
Neuromorphic engineeringMaterials scienceHeterojunctionOptoelectronicsNon-volatile memory
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Plants are essential for human survival. Over the past three decades, work with the reference plant Arabidopsis thaliana has significantly advanced plant biology research. One key event was the sequencing of its genome 25 years ago, which fostered many subsequ…
openalex
Siobhán M. Brady, Gabriela Auge, Mentewab Ayalew, Sureshkumar Balasubramanian 等
2025-03-01
置信度 0.72
ArabidopsisPlant biologyArabidopsis thalianaNexus (standard)Biology
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Abstract Aim We develop a novel modelling framework for analysing the spatio‐temporal spread of biological invasions. The framework integrates different invasion drivers and disentangles their roles in determining observed invasion patterns by fitting models t…
openalex
Thomas Mang, Franz Essl, Dietmar Moser, Ingrid Kleinbauer 等
2018-02-23
置信度 0.72
Biological dispersalMarkov chain Monte CarloComputer sciencePropagule pressureInference
-
Agent-based modeling (ABM) is a powerful computational approach for studying complex biological and biomedical systems, yet its widespread use remains limited by significant computational demands. As models become increasingly sophisticated, the number of para…
openalex
Kerri‐Ann Norton, Daniel Bergman, Harsh Jain, Trachette L. Jackson
2025-12-03
置信度 0.72
Computer scienceManagement scienceBiochemical engineeringData scienceEngineering
-
BACKGROUND: Chondrosarcomas are common solid malignant tumors of bone, second in incidence only to osteosarcomas. The biologic evolution of chondrosarcomas is slow, requiring long follow-up intervals for meaningful survival analysis. METHODS: This study descri…
openalex
Johannes Bj�rnsson, Richard A. McLeod, K. Krishnan Unni, Duane M. Ilstrup 等
1998-11-15
置信度 0.72
MedicineChondrosarcomaPrimary (astronomy)AnatomySurgery
-
Neurological disorders are a substantial global health burden, affecting millions of people worldwide. A key challenge in developing effective treatments and preventive measures is the realization of low-power wearable systems with early detection capabilities…
openalex
Matteo Farronato, Piergiulio Mannocci, Alessandro Milozzi, Christian Monzio Compagnoni 等
2025-01-17
置信度 0.72
Trap (plumbing)Charge (physics)Computer scienceReservoir computingOptoelectronics
-
In biological systems, form and function are inherently correlated. Despite this strong interdependence, the biological effect of curvature has been largely overlooked or underestimated, and consequently it has rarely been considered in the design of new cell-…
openalex
Danielle Baptista, Liliana Moreira Teixeira, Clemens van Blitterswijk, Stefan Giselbrecht 等
2019-03-16
置信度 0.72
CurvatureSubstrate (aquarium)ChemistryBiologyBiological system
-
Summary: Modern biological research critically depends on public databases. The introduction and propagation of errors within and across databases can lead to wasted resources as scientists are led astray by bad data or have to conduct expensive validation exp…
openalex
Mihai Pop, Teresa K. Attwood, Judith A. Blake, Philip E. Bourne 等
2024-12-26
置信度 0.72
Stewardship (theology)Computer scienceData scienceGenerative grammarBiological data
-
Despite two decades of intensified research to understand and cure tuberculosis disease, biological uncertainties remain and hamper progress. However, owing to collaborative initiatives including academia, the pharmaceutical industry and non-for-profit organiz…
openalex
Véronique Dartois, Eric J. Rubin
2022-04-27
置信度 0.72
BiologyTuberculosisDrug developmentDrugComputational biology
-
Unknown primary cancer (UPC) is defined by the presence of metastatic disease for which a primary site is undetectable on presentation. Computed tomography scan of the body was performed routinely in search of the primary cancer and invasive procedures were pu…
openalex
Gauri R. Varadhachary, James L. Abbruzzese, Renato Lenzi
2004-03-22
置信度 0.72
MedicineBreast cancerRadiologyPositron emission tomographyMagnetic resonance imaging
-
Often large quantities of plastics are found in compost, with price look-up stickers being a major but little-explored component in the contamination path. Stickers glued to fruit or vegetable peels usually remain attached to the organic material despite sorti…
openalex
Max Groß, Matthias Mail, Olivia Wrigley, Rafaela Debastiani 等
2024-04-10
置信度 0.72
CompostDegradation (telecommunications)Scanning electron microscopeFourier transform infrared spectroscopyChemistry
-
Synaptic-resolution network connectomics has revealed that brain circuits feature fine-scale structural connectivity, such as pairs of correlated synaptic couplings known as second-order motifs. Large-scale recordings of neuronal activity in networks containin…
datacite
Zhang, Meiyi, Yu, Jinjian, Tao, Louis, Shao, Yuxiu
2026
置信度 0.66
Neurons and Cognition (q-bio.NC)Disordered Systems and Neural Networks (cond-mat.dis-nn)Neural and Evolutionary Computing (cs.NE)FOS: Biological sciencesFOS: Physical sciences
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تحلیل فوقدکتری جامع، فوقتخصصی، بدون کوچکترین سادهسازی و کاملاً ضدگلوله برای نظریه و معمای شماره ۴۱ از ۱۰۰ (از کلانمجموعه مهندسی و دستکاری ساختار واقعیت با نام تجاری HamzahXcell): «کدگ��اری میدانهای انسجام بوزونی بوز-اینشتین برای ساخت لیزرهای مادی صلب گرا…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
-
تحلیل فوقدکتری جامع، فوقتخصصی، بدون کوچکترین سادهسازی و کاملاً ضدگلوله برای نظریه و معمای شماره ۴۱ از ۱۰۰ (از کلانمجموعه مهندسی و دستکاری ساختار واقعیت با نام تجاری HamzahXcell): «کدگذاری میدانهای انسجام بوزونی بوز-اینشتین برای ساخت لیزرهای مادی صلب گران…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
-
This paper proposes a novel computing architecture that diverges from the traditional Von Neumann model by integrating computation and storage within a neuromorphic network. The core concept involves utilizing a neural network constructed from novel storage me…
datacite
Zhang, Jincheng
2026
置信度 0.66
-
This paper proposes a novel computing architecture that diverges from the traditional Von Neumann model by integrating computation and storage within a neuromorphic network. The core concept involves utilizing a neural network constructed from novel storage me…
datacite
Zhang, Jincheng
2026
置信度 0.66
-
🌀 LRO-κ⁸ SPINE + 3.1.3 MASTER FILE including cross platform LRO-κ⁸ SPINE + 3.1.3 : A Geometric Control Language for Quantum-Holographic Field Manipulation – Extended AI Migration Protocol with Holographic GPU, Quantum Circuit Execution, Volumetric Field-Effec…
datacite
Blakeley, Christopher
2026
置信度 0.66
-
🌀 LRO-κ⁸ SPINE + 3.1.3 MASTER FILE including cross platform LRO-κ⁸ SPINE + 3.1.3 : A Geometric Control Language for Quantum-Holographic Field Manipulation – Extended AI Migration Protocol with Holographic GPU, Quantum Circuit Execution, Volumetric Field-Effec…
datacite
Blakeley, Christopher
2026
置信度 0.66
-
تحلیل فوقدکتری جامع، فوقتخصصی، بدون کوچکترین سادهسازی و کاملاً ضدگلوله برای نظریه و معمای شماره ۳۱ از ۱۰۰ (از کلانمجموعه مهندسی و دستکاری ساختار واقعیت با نام تجاری HamzahXcell): «ماتریس فرکتالی میدانهای پیمانهای برای هک پروتکلهای برهمکنش قوی هستهای»…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
-
تحلیل فوقدکتری جامع، فوقتخصصی، بدون کوچکترین سادهسازی و کاملاً ضدگلوله برای نظریه و معمای شماره ۳۱ از ۱۰۰ (از کلانمجموعه مهندسی و دستکاری ساختار واقعیت با نام تجاری HamzahXcell): «ماتریس فرکتالی میدانهای پیمانهای برای هک پروتکلهای برهمکنش قوی هستهای»…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
-
تحلیل فوقدکتری جامع، فوقتخصصی، بدون کوچکترین سادهسازی و کاملاً ضدگلوله برای نظریه و معمای شماره ۱۱ از ۱۰۰ (از کلانمجموعه مهندسی و دستکاری ساختار واقعیت با نام تجاری HamzahXcell): «کنترل و برنامهنویسی نوسانات کوانتومی خلاء برای خلق ماده پایدار از هیچ» ($\…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
-
تحلیل فوقدکتری جامع، فوقتخصصی، بدون کوچکترین سادهسازی و کاملاً ضدگلوله برای نظریه و معمای شماره ۱۱ از ۱۰۰ (از کلانمجموعه مهندسی و دستکاری ساختار واقعیت با نام تجاری HamzahXcell): «کنترل و برنامهنویسی نوسانات کوانتومی خلاء برای خلق ماده پایدار از هیچ» ($\…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
-
تحلیل فوقتخصصی، فرمولبندی هندسی-ریاضیاتی و اثبات سطح فوقدکتری جامع، بدون کوچکترین سادهسازی و کاملاً ضدگلوله برای نظریه و معمای شماره ۱ از ۱۰۰ (از کلانمجموعه دستکاری و مهندسی فضا-زمان با نام تجاری HamzahXcell): «مهندسی هولوگرافیک ساختار محاسباتی فضا-زمان»…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
-
تحلیل فوقتخصصی، فرمولبندی هندسی-ریاضیاتی و اثبات سطح فوقدکتری جامع، بدون کوچکترین سادهسازی و کاملاً ضدگلوله برای نظریه و معمای شماره ۱ از ۱۰۰ (از کلانمجموعه دستکاری و مهندسی فضا-زمان با نام تجاری HamzahXcell): «مهندسی هولوگرافیک ساختار محاسباتی فضا-زمان»…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
-
• Published on bioRxiv, presenting the first quantum algorithm to dramatically accelerate Flux Balance Analysis (FBA), a core technique in cellular metabolism research. • Overcomes the computational limits of existing classical computing by introducing the Qua…
datacite
inquantio
2026
置信度 0.66
quantum biology
-
This specification develops a unified lifecycle design for a permanent Mars colony scaling from initial outpost (~2046) through terraforming-class capability (~2100+). The design centers on pit-crater architecture using natural basalt walls as primary structur…
datacite
Lusk, A. C.
2026
置信度 0.66
marsspace settlementplanetary engineeringISRUlifecycle design
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This specification develops a unified lifecycle design for a permanent Mars colony scaling from initial outpost (~2046) through terraforming-class capability (~2100+). The design centers on pit-crater architecture using natural basalt walls as primary structur…
datacite
Lusk, A. C.
2026
置信度 0.66
marsspace settlementplanetary engineeringISRUlifecycle design
-
ABSTRACT: This paper introduces the formal implementation and verification of the V3 Architecture (Blida Standard) encapsulated within the Ada/SPARK axiomatic type system, achieving a paradigm shift from traditional stochastic and empirical computing to absolu…
datacite
benhadid, outail
2026
置信度 0.66
Ada/SPARK, Blida Standard, V3 Architecture, Formal Verification, Saturating Arithmetic, Heptadic Closure, DO-178C DAL A, O(1) Complexity, Deterministic Systems, Axiomatic Type System, Modulo-9, Digital Root, GNATprove, Runtime Exception Absence, AoRTE, Static Analysis, Phase Coherence, Numerical Stability
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ABSTRACT: This paper introduces the formal implementation and verification of the V3 Architecture (Blida Standard) encapsulated within the Ada/SPARK axiomatic type system, achieving a paradigm shift from traditional stochastic and empirical computing to absolu…
datacite
benhadid, outail
2026
置信度 0.66
Ada/SPARK, Blida Standard, V3 Architecture, Formal Verification, Saturating Arithmetic, Heptadic Closure, DO-178C DAL A, O(1) Complexity, Deterministic Systems, Axiomatic Type System, Modulo-9, Digital Root, GNATprove, Runtime Exception Absence, AoRTE, Static Analysis, Phase Coherence, Numerical Stability
-
تحلیل فوقدکتری جامع، فوقتخصصی، بدون کوچکترین سادهسازی و کاملاً ضدگلوله برای نظریه و معمای شماره ۷۱ از ۱۰۰ (فاز پیشرفته مهندسی ارگانیک و بیوفیزیک فرین در پروتکل جامع فیزیک اطلاعات حمزه) با نام تجاری HamzahXcell: «ماتریس توپولوژیک میدانهای چرخش فرومونیک-کوا…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
-
تحلیل فوقدکتری جامع، فوقتخصصی، بدون کوچکترین سادهسازی و کاملاً ضدگلوله برای نظریه و معمای شماره ۶۱ از ۱۰۰ (فاز پیشرفته کلاننظریهها و مهندسی پروتکلهای خلاء با نام تجاری HamzahXcell): «کدگذاری فرکانسهای میدان شبهذرهای اکسیوتون برای هک پروتکلهای بازتاب…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
-
اَبَر-لاگرانژین ۱۱۵۵ حمزه در بستر فیزیک اطلاعات و اثبات وضعیت آن ۴ فلشمموری، باید این معادله را به عنوان یک «میدان اطلاعاتی جامع» تحلیل کنیم. در این مدل، فلشمموری دیگر یک شیء فیزیکی نیست، بلکه یک تکینگی اطلاعاتی (Information Singularity) در فضای ۱۱۵۵-بعدی اس…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
-
اَبَر-لاگرانژین ۱۱۵۵ حمزه در بستر فیزیک اطلاعات و اثبات وضعیت آن ۴ فلشمموری، باید این معادله را به عنوان یک «میدان اطلاعاتی جامع» تحلیل کنیم. در این مدل، فلشمموری دیگر یک شیء فیزیکی نیست، بلکه یک تکینگی اطلاعاتی (Information Singularity) در فضای ۱۱۵۵-بعدی اس…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
-
Tomato serves as a globally important vegetable crop and a genetic model organism, and the improvement of its agronomic traits represents a central objective in breeding. While graph-based pangenomes comprehensively capture species-wide genetic diversity, thos…
pubmed
Su X, Du R, Xing Z, Yang Q 等
2026 Sep
置信度 0.82
-
Surgical scene reconstruction is a critical prerequisite for intraoperative navigation in robotic surgery. Although deep neural networks (DNNs) have advanced surgical scene reconstruction, their performance degrades severely when confronted with texture-sparse…
pubmed
Xiaoxi L, Gan L, Bingwen D, Guangcheng C 等
2026 Dec
置信度 0.82
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Ischemic brain injury is a major contributor to global mortality and disability. Despite extensive pathological characterization, systematic integration of rodent transcriptomic data remains limited. This study investigates orthologous transcription factors (T…
pubmed
Xu H, Huang X, Hong MY, Xu J 等
2026
置信度 0.82
-
This study aimed to investigate the association between a pro-inflammatory diet in pregnancy, assessed via the Dietary Inflammatory Index (DII), and abnormal perinatal outcomes (APOs), including miscarriage and stillbirth. Leveraging the UK Biobank cohort, we …
pubmed
Sheng L, He W, Wang F, Weng X 等
2026
置信度 0.82
-
The PD-1/PD-L1 axis plays a critical role in suppressing T-cell activation and facilitating immune evasion in lung adenocarcinoma (LUAD). This study focused on PD-1-related genes to develop a robust prognostic prediction model for LUAD.
pubmed
Jia B, Gong T, Chen C, Sun B 等
2026
置信度 0.82
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Alternative splicing enables a single gene to produce a variety of mRNA transcripts, significantly enhancing protein diversity in higher eukaryotes. Isoform switching refers to the differential usage of a gene's transcripts and occurs pervasively across physio…
pubmed
Han C, Gilis J, Delgado EI, Clement L 等
2026 Sep
置信度 0.82
-
[This corrects the article DOI: 10.3389/fbinf.2026.1816121.].
pubmed
Angarita-Rodríguez A, Vargas-López V, Pinzón A, Sandoval-Hernandez A 等
2026
置信度 0.82
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Upper airway structure and function are affected in several respiratory (e.g., obstructive sleep apnoea, allergic rhinitis, and asthma) and congenital [e.g., Down syndrome (DS)] conditions. Although murine models are widely used to study airway pathology and t…
pubmed
Belmans F, Llambrich S, Vos W, Maes F 等
2026
置信度 0.82
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Despite significant advances in therapeutic techniques, Myocardial infarction (MI) is an important root cause of morbidity and death worldwide. Metformin (MET), a primary antidiabetic medication, has been studied for its possible cardioprotective properties. T…
pubmed
Saini D, Maharana KC, Jha KP, Singh S
2026 Sep
置信度 0.82
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Although several tools exist for prokaryotic genome correction, most depend on external read mappers that impose computational overhead and usability barriers, leaving a need for fast, accurate, standalone solutions. We present ProGenFixer, a mapping-free tool…
pubmed
Song L, Wang M, Liao X, Wu J 等
2026
置信度 0.82
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Chronic hormonal imbalances and associated symptoms characterize ovarian cancer. PARP-1 inhibitors, such as olaparib and ruparib, are used to treat it, but new drugs are needed to overcome toxicity and resistance issues. PARP inhibition in BRCA1/2 -mutated can…
pubmed
Dey S, Wadhwa K, Kumari N, Pandey C 等
2026
置信度 0.82
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To address the issues of feature redundancy in the feature extraction process, as well as the fact that the simulation of biological neural activity remains limited in the SNN encoding layer and the lack of temporal information in the SNN encoding layer, the s…
pubmed
Wang Y, Bai J, Zhang H, Wu Y
2026
置信度 0.82
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A novel series of pyrazole-pyridine-1,3,4-oxadiazole hybrid derivatives (10a-m) was designed, synthesized, and characterized by IR, 1 H NMR, 13 C NMR, mass spectrometry, and elemental analysis. The multi-step route proceeded via nucleophilic aromatic substitut…
pubmed
Dave PA, Maheta JB, Lakhnotra DK, Shaikh NH 等
2026 Aug 26
置信度 0.82
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Achieving atomic-level insight into how dopants regulate the electrocatalytic CO 2 reduction reaction (eCO 2 RR) of metal nanoparticles is challenging due to the lack of well-defined, compositionally tunable, and structurally identical model systems. Herein, w…
pubmed
Deng G, Kim J, Yan Q, Park S 等
2026 Aug 26
置信度 0.82
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Region-based epigenome-wide association studies have demonstrated improved statistical power and biological interpretability compared with probe-wise analyses of DNA methylation data. However, most existing region-based methods characterize methylation dysregu…
pubmed
Chatterjee S, Meshram S, Arunkumar G, Tekola-Ayele F 等
2026 Sep
置信度 0.82
-
Depression, anxiety, insomnia, and muscle spasms are globally prevalent disorders. Although Baccaurea motleyana is traditionally used in folk medicine, its neuroprotective efficacy remains unexplored. This study evaluates the anxiolytic, antidepressant, sedati…
pubmed
Ahsan MT, Ekram MEH, Al Mahmud K, Hasan T 等
2026
置信度 0.82
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This contribution highlights a coherent series of recent computational studies devoted to the theoretical characterization of mechanically interlocked molecules (MIMs)-specifically [2]rotaxane molecular shuttles and switches-in organic solvents. Combining dens…
pubmed
Zazza C
2026 Sep
置信度 0.82
-
In this work, we introduce carbon as a novel electrode material in retinal prosthesis. We fabricate Si-based photovoltaic retinal implants with single p-n junctions in 40 µm and 200 µm pixels and successfully integrate pyrolytic carbon elec…
pubmed
Matsumoto A, Kusumanchi P, Madsen JG, Jørgensen AC 等
2026 Aug 25
置信度 0.82
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Multidomain proteins connected by flexible linkers populate conformational ensembles that are challenging to characterize using conventional structural biology methods. In domain-linker-domain (DLD) proteins, linker-mediated inter-domain relative positions and…
pubmed
Rodriguez S, Fournet A, Bartels S, Pajkos M 等
2026 Aug 26
置信度 0.82
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Trained immunity enhances long-term innate immune responsiveness through metabolic and epigenetic rewiring. Using BCG as a model, we demonstrate that inhibition of acetyl-CoA carboxylase 1 (ACC1) enhances BCG-induced trained immunity by increasing intracellula…
pubmed
Baydemir I, Nikolka F, Bulut Ö, Ferreira AV 等
2026 Aug 25
置信度 0.82
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Influenza virus has circulated in the human population and co-evolved with us for centuries or longer, shaping our immune repertoires through a continuous host-virus arms race. Across individuals, antibodies repeatedly converge on shared solutions for capturin…
pubmed
Andrews SF, Kanekiyo M
2026 Aug
置信度 0.82
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The management of acute ischemic stroke has shifted from rigid time-based protocols to imaging-driven, tissue-based reperfusion strategies. Non-contrast CT and CT angiography remain the indispensable frontline for rapid triage, particularly in community and lo…
pubmed
Xu K, Lyu J, Lou X
2026 Aug 25
置信度 0.82
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With the increasing frequency and growing complexity of food and environmental contaminants, there is a clear need for advanced sensing platforms that offer high sensitivity, rapid response times, and broad analytical applicability. Carbon dots (CDs), widely r…
pubmed
Hsu CY, Rodrigues P, Shakhmurova G, Rabbimova N 等
2026 Aug 25
置信度 0.82
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Three-dimensional genome organization is maintained in part by chromatin insulators, DNA-protein complexes that create boundaries between active and inactive chromatin and regulate enhancer-promoter interactions. In Drosophila, the Homing insulator at eve (Hom…
pubmed
Lyda SF, McManus CE, Caravaca JM, Yang D 等
2026 Aug 6
置信度 0.82
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Reconstructing genomes from metagenomic assemblies is foundational to microbiome research, yet binning faces a persistent trade-off between fidelity and throughput. Many high-accuracy methods rely on GPU-intensive workflows, marker-gene postprocessing, or heav…
pubmed
Bushnell B, Villada JC
2026 Aug 25
置信度 0.82
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Cell-free DNA (cfDNA) provides a non-invasive means to monitor physiological states and diagnose diseases, with widespread applications in oncology. Our lab utilizes cfDNA as a tool to investigate the state of the tumor and the tumor microenvironment in patien…
pubmed
Eramo S, Weirich A, Ramachandran S
2026
置信度 0.82
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Small RNAs (sRNAs), broadly defined as RNA molecules shorter than ~200 nucleotides in size, include miscellaneous products of transcription and post-transcriptional processing that are variably abundant in cancer cells. While some types of sRNAs, such as micro…
pubmed
Silva V, Kandooru S, Parrello D, Froelich B 等
2026
置信度 0.82
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Long non-coding RNAs (lncRNAs) represent a significant yet underexplored component of the human genome, with emerging evidence linking them to various biological processes and diseases. Despite over 205,000 lncRNAs documented in existing databases, a substanti…
pubmed
Guda C, Jagadesan S, Veerappa A
2026
置信度 0.82
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Single-cell approaches to study gene regulation using multi-modal data (sc-Multiome), such as genomes, transcriptomes, and chromatin accessibility of tumor cells, offer great insights into the development trajectory. By enabling high-resolution barcoding, sing…
pubmed
Veerappa A, Guda C
2026
置信度 0.82
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Investigating the physiological regulation of the epigenome using genetically engineered mouse models, with a focus on heterochromatic regions of DNA, presents two major challenges: (i) the isolation and preparation of high-quality nuclei from tissue for analy…
pubmed
Wani SA, Wasylishen AR
2026
置信度 0.82
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The Assay for Transposase-Accessible Chromatin followed by sequencing (ATAC-seq) is a powerful and widely-used technique for chromatin accessibility profiling due to its low input requirement, simple protocol, high sensitivity, and ability to study single cell…
pubmed
Gura K, Long T, Takaku M, Dhasarathy A 等
2026
置信度 0.82
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Analysis of DNA co-immunoprecipitated with proteins of interest has been foundational to our understanding of chromatin and its regulation. Despite the emergence of crosslink-free techniques such as CUT&RUN and CUT&TAG, Chromatin Immunoprecipitation fo…
pubmed
Bigelow Z, Nechaev S, Dhasarathy A
2026
置信度 0.82
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Tip-growing cells exhibit complex growth regimes in vitro, alternating between growing and non-growing intervals, oscillatory or more steady behavior. In Arabidopsis thaliana, pollen tube growth arrest is often accompanied by spiking behavior in intracellular …
pubmed
Portes MT, Damineli DSC, Feijó JA
2026
置信度 0.82
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Pollen tubes are a widely used model for the extension and development of polarized cells. Their relatively standard shape simplifies automated identification and image analysis of subregions. The key is reliable identification of the cell plasma membrane and …
pubmed
Adler J, Parmryd I
2026
置信度 0.82
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Protein functions are essential for understanding life at the molecular level. High-throughput sequencing generates vast amounts of raw protein sequences, but only about 1 percent have been carefully annotated with their functions. The experimental research ne…
pubmed
Senapati B, Das R
2026 Aug 26
置信度 0.82
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Tracing specific trajectories allows a walker to revisit previous locations. However, how such local memory-based rules influence large-scale movement patterns remains unclear. In this paper, we propose a single walker model that explores a two-dimensional lat…
pubmed
Sakiyama T
2026 Aug 25
置信度 0.82
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Enhancers control tissue-specific gene expression across animals 1 . Although deep learning 2,3 has enabled enhancer prediction and design in mammalian cell lines and non-mammalian model organisms 4-10 (reviewed in a previous publication 11 ), it remains uncle…
pubmed
Chen S, Loubiere V, Hollingsworth EW, Murakami K 等
2026 Aug 25
置信度 0.82
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The 3D structure of chromatin is altered in cancer. In healthy cells, the genome is folded into functional 3D structural elements, including chromosomes, chromatin compartments, domains and loops. Cancer-associated alterations can modify each of these structur…
pubmed
Franceschini GM, Georgakopoulou K, Ciriello G, Oricchio E
2026 Aug 25
置信度 0.82
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A recent study reported sequence biases in transcription factor (TF) footprinting data, and expressed concern about the accuracy in TF footprint discovery using V-plot analysis. Here we define two graphical parameters of V-plot as important criteria to impleme…
pubmed
Zhang Q, Xu C
2026 Aug 25
置信度 0.82
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Early and reliable diagnosis of hibiscus leaf diseases is critical to protect horticultural yield. Yet, it remains challenging under real-time field conditions where uncontrolled lighting, clutter, and the non-contiguous nature of pathological symptoms blur di…
pubmed
Billah MM, Sagor S, Hossain S, Alahmadi TJ 等
2026 Jul 23
置信度 0.82
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To advance precision medicine in pathology, artificial intelligence (AI)-driven foundation models must generalize across diverse datasets, tissues, and clinical tasks. However, their comparative performance and generalizability in computational pathology remai…
pubmed
Bareja R, Carrillo-Perez F, Zheng Y, Pizurica M 等
2026 Jul 24
置信度 0.82
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The DICER1 gene is mutated in cancer, including in DICER1-related tumour predisposition. Cancer-associated hotspot mutations have been reported in both catalytic domains of DICER and are predicted to disrupt miRNA biogenesis. To understand how these hotspot mu…
pubmed
Gordon K, Bellora N, Witteveldt J, Wojtus JK 等
2026 Jul 25
置信度 0.82
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Angiosarcoma is a poorly understood sarcoma due to its high heterogeneity and rarity. Here we show a comprehensive clinical and molecular analysis of a large cohort of 254 angiosarcoma patients through the patient-partnered Angiosarcoma Project. By integrating…
pubmed
Chu H, Hollyer M, Borden BA, Reilly CR 等
2026 Jul 24
置信度 0.82
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Biochemical analysis complements biophysical measurements by capturing the underlying molecular and metabolic changes that drive physiological health. Here, we introduce a compact, fully integrated smart ring capable of simultaneously monitoring multiple chemi…
pubmed
Saha T, Ding S, Qin S, Fishman H 等
2026 Jul 23
置信度 0.82
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Hepatitis C virus (HCV) affects 47 million people and causes 239,000 deaths annually, yet no vaccine is on the horizon. Generating a stable native-like mimic of the envelope complex E1E2, the only target for known neutralizing antibodies, is an important aim f…
pubmed
Capella-Pujol J, Mulder F, Cannac F, Peters S 等
2026 Jul 23
置信度 0.82
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Critical illness, including COVID-19 and trauma, induce immune dysregulation associated with morbidity and mortality. Direct comparison is crucial to identify shared pathobiological mechanisms to guide precision therapies. This prospective cohort study underto…
pubmed
Wood AJT, Albers GJ, Cornelissen W, Maiden JD 等
2026 Aug 25
置信度 0.82
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Next-generation sequencing of cancer predisposition genes is routinely used in hereditary cancer diagnostics. However, a substantial fraction of detected variants remains clinically unresolved. Using a customised 77-gene panel, we analysed 2142 individuals and…
pubmed
Calandra N, Mereu E, Ogliara P, Casalis Cavalchini G 等
2026 Aug 25
置信度 0.82
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Type III secretion system effectors (T3SEs) are small bacterial proteins with big biological roles. They act as central molecular mediators of interactions between Gram-negative bacteria and eukaryotic hosts, spanning pathogenic, symbiotic and environmental co…
pubmed
Rosić I, Nikolić I
2026 Aug 26
置信度 0.82
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Many biological microswimmers can modulate their swimming gait to achieve directional control of motility, especially when performing steering towards specific directional cues. This can be achieved without the need for obvious morphological or structural asym…
pubmed
Walker BJ, Moreau C, Robinson TL, Xu ZJ 等
2026 Aug 26
置信度 0.82
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The COVID-19 pandemic response relied heavily on statistical and machine learning models to predict key outcomes such as case prevalence and fatality rates. These predictions were instrumental in enabling timely public health interventions that helped break tr…
pubmed
Raghuvamsi PV, Loh SB, Bhattacharya P, Ho J 等
2026 Aug 25
置信度 0.82
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Protein lipidation is a widespread strategy for anchoring proteins to cellular membranes across all domains of life, yet the mechanisms underlying this process in archaea remain poorly understood. Recently, the first archaeal enzymes involved in lipobox-contai…
pubmed
Hong Y, Garcia A, Kopelev S, Cote JA 等
2026 Aug 25
置信度 0.82
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This study introduces a statistical mechanical framework for allosteric communication in proteins based on the spanning-tree ensemble of residue contact networks. By representing Cα protein backbones as weighted graphs, we identify each spanning tree as …
pubmed
Senguler Ciftci F, Erman B
2026 Aug 25
置信度 0.82
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Orthoebolavirus outbreaks place health-care workers (HCWs) at substantial risk, and HCW illness or death can weaken response capacity. The 2026 Bundibugyo virus outbreak in DR Congo highlights the need for deployable countermeasures when species-specific vacci…
pubmed
Stapley JN, Ko Y, Jeyapragasan G, Chan EMG 等
2026 Aug 25
置信度 0.82
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Fricke gel dosimeters, also known as hydrogels, have emerged as attractive tools in clinical dosimetry due to the requirements of quality assurance protocols and radiation protection programs. The performance of these materials strongly depends on the characte…
pubmed
Dos Santos AMM, Araújo LF, Costa L, Araujo N 等
2026 Aug 25
置信度 0.82
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Splenomegaly is a defining feature of myelofibrosis, yet the contribution of splenic mesenchymal stroma to disease progression remains unclear. We combined spatial and single-nucleus transcriptomics of patient spleens with spatial and single-cell transcriptomi…
pubmed
Dugué B, Wanner P, Ruiz Tejada Segura ML, Saad M 等
2026 Aug 25
置信度 0.82
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Abnormal glycolysis, enhanced metastatic potential, and dysregulated oncogenic signaling, including integrin β1 and c-Met pathways, are key drivers of triple-negative breast cancer (TNBC) progression and contribute to its poor prognosis and limited thera…
pubmed
Wu N, Luo Y, Quan Q, Huang X 等
2026 Aug 19
置信度 0.82
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Purine-derived scaffolds remain important in anticancer and antiviral drug discovery because their electronic properties, hydrogen-bonding capacity, and conformational adaptability support interactions with kinases, polymerases, nucleotide-processing enzymes, …
pubmed
Nidhar M, Alam P, Alqarni MH, Foudah AI 等
2026 Aug 21
置信度 0.82
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Living materials, defined by dynamic biological activity and responsive capabilities, are emerging as pivotal therapeutic agents in biomedicine. Their therapeutic effects are driven by active interactions with biological entities at multiple levels. However, m…
pubmed
Du S, Liu Y, Liu Y, Tan Y 等
2026 Aug 20
置信度 0.82
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Cancer immunotherapy has reshaped oncology, yet its broad application is constrained by an immunosuppressive tumor microenvironment and the systemic toxicities of conventional treatments. This review traces the evolution of nanomedicine from a passive drug del…
pubmed
Wu Y, Tang F, Lee J, Liang Y 等
2026 Aug 17
置信度 0.82