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• Longitudinal inference of hippocampal volume and morphometric hippocampal-cortical covariance in psychosis.
  Schizophrenia and related psychoses are characterized by reductions in hippocampal volume and morphometric hippocampal-cortical covariance. No study to date has inferred the temporal relationship between deviations in subfield and adjacent white matter volume …
  pubmed Totzek JF, Heckers S, Palaniyappan L, Young AL 等 2026 Aug 6 置信度 0.82
• Physical and mental health among seasonal migrant farmworkers: Evidence from a survey conducted in northwestern Italy.
  Farmworkers exhibit a higher prevalence of musculoskeletal disorders, levels of anxiety, depression, and work-related stress compared with general population. However, few studies have investigated the main predictors of these outcomes. Therefore, this study a…
  pubmed Sodano B, Catalano A, Avanzi S, Gebru KT 等 2026 Aug 25 置信度 0.82
• Trace element-based Co(II) and Fe(III) mixed-ligand complexes of phenanthroline and sulfasalazine: Structural, DFT, molecular docking, and antimicrobial studies.
  New mixed ligand compounds FeSUPT and CoSUPT were successfully prepared using sulfasalazine (SU) and phenanthroline (PT). The compounds were recovered as solid, non-electrolyte substances with good thermal stability (above 300°C) and low molar conductivit…
  pubmed Khalaf MM, Abd El-Lateef HM, Eltayeb H, Abdou A 2026 Aug 20 置信度 0.82
• Can 18F-FDG PET/CT SUV(max) values predict breast and axillary pathological complete response before neoadjuvant chemotherapy in breast cancer?
  We aimed to investigate whether maximum standardized uptake value (SUV max ) values of breast mass and axilla metastatic lymph nodes are effective independent predictive factors for breast and axillary pathological complete response (PCR) before neoadjuvant ch…
  pubmed Koca B, Yildirim M, Saglam AI, Ozsoy U 2026 置信度 0.82
• Metabolomics of Eryngium heterophyllum by UHPLC-QToF-MS and In Silico Insights Into Potential Metabolic Syndrome Targets.
  Eryngium heterophyllum (toad grass) is native to Mexico and has been used traditionally to manage diabetes, hypercholesterolemia, and arthritis. However, its bioactive compounds remain poorly characterized. This study profiled the phytochemical composition of …
  pubmed Gutiérrez-Rodelo C, Galván LEM, Estrada-Lugo E, Avula B 等 2026 Aug 置信度 0.82
• Identification of candidate macrophage-ferroptosis crosstalk genes associated with immune infiltration in myocardial infarction: A bioinformatics analysis.
  Globally, myocardial infarction (MI) remains a major cause of morbidity and mortality. Macrophage-mediated inflammation and ferroptosis-related stress responses have both been implicated in MI; however, transcriptomic identification of macrophage- and ferropto…
  pubmed Wang G, Zhang Z, Yang G, Wang J 等 2026 置信度 0.82
• High reelin expression may explain why a subgroup of entorhinal cortex neurons functions as an initial nucleation site of Alzheimer's disease.
  The entorhinal cortex (EC) plays a crucial role in memory functions. Long before the clinical symptoms of Alzheimer's disease (AD) emerge, it has already undergone significant degeneration, making it a primary site for the onset of the disease. The reasons for…
  pubmed Kobro-Flatmoen A, Hussan JR, Hunter PJ, Omholt SW 2026 Aug 置信度 0.82
• Theory and evidence of amplitude control by frequency detuning in a coupled neuronal oscillator system.
  Neuronal oscillator circuits that generate rhythmic movements must operate flexibly and reliably to produce the varied motor patterns that animals exhibit naturally. Rodents rhythmically "whisk" their vibrissae for haptic perception, and they dynamically adjus…
  pubmed Lu AC, Ourang SA, Moore JD 2026 Aug 25 置信度 0.82
• A unified CPG-based and multi-agent control framework for low-cost quadruped robots.
  Quadruped robots have gained significant attention due to their superior mobility on uneven and unstructured terrains, offering potential applications in inspection, search and rescue, and field exploration. However, achieving robust locomotion on low-cost pla…
  pubmed Wu L, Zhang M, Wang W 2026 置信度 0.82
• The multi-omics fallacy in microbiome science.
  Artificial intelligence and machine-learning-assisted multi-omics have expanded the scale and ambition of microbiome research, but they have also sharpened an older interpretive problem. Biologically plausible structure is too easily mistaken for biological ex…
  pubmed Lewandowski R 2026 Aug 置信度 0.82
• A decade of artificial intelligence research in ophthalmology: Global trends and transferable insights for medical AI.
  To characterize global trends in ophthalmic AI research from 2015-2025 and drive transferable insights into the broader evolution of AI in medicine, we conducted a systematic bibliometric analysis of original AI articles in ophthalmology indexed in the Web of …
  pubmed Fan Z, Qin Y, Chen L, Yuan J 等 2026 Aug 置信度 0.82
• Community-driven updates for comprehensive long-read metagenomics and enhanced binning in nf-core/mag v5.
  nf-core/mag is a reproducible Nextflow pipeline for best-practice metagenomic de novo assembly, and binning within the nf-core framework. Here we present a major update that adds support for long-read-only assembly and bin refinement, includes five new binning…
  pubmed Alvarez Saravia D, Rosenbaum A, Straub D, Downie J 等 2026 Aug 25 置信度 0.82
• Morphing active networks.
  Biological networks like leaf venation exhibit remarkable morphing capabilities that enable organisms to adapt and thrive in their environments. However, the underlying mechanisms that govern the morphing of such networks, especially when the network itself ac…
  pubmed Wen Y, Chen Y, Yang Y, Xu F 2026 Sep 置信度 0.82
• Overview of exosomal non-coding RNAs in cardiovascular disease using high throughput sequencing.
  Non-coding RNAs including miRNAs, long-ncRNAs, and circular RNAs play crucial roles in cell-to-cell communication and epigenetic regulation. They control gene expression at multiple levels, including transcriptional, post-transcriptional, and translational, th…
  pubmed Eivazi M, Abkhooie L, Hosseini K, Mobasheran P 等 2025 Nov 15 置信度 0.82
• Single-Cell Glycomics of the Pancreatic Tumor Microenvironment: Technologies, Glyco-Immune Checkpoints, and Tumor-Immune Communication.
  In this Review, we summarize recent conceptual and technological advances in single-cell glycomics, with a particular focus on emerging strategies that enable glycan-resolved analysis of tumor-immune interactions. We highlight single-cell glycan and RNA sequen…
  pubmed Anh DXT, Tateno H 2026 Aug 置信度 0.82
• RGCNMDA: Pathway-Bridged Relational Graph Learning with Adaptive Multi-View Fusion for Human miRNA-Disease Association Prediction.
  MicroRNAs are key post-transcriptional regulators whose dysregulation is associated with complex human diseases. Computational prediction can prioritize candidate miRNA-disease associations, but reliable evaluation is complicated by sparse labels, cold-start e…
  pubmed Hou C, Kone M, Xiang Y, Wang S 2026 Aug 25 置信度 0.82
• Bioinformatic identification of THY1 as a target in osteoarthritis and its effects on chondrocyte senescence and apoptosis.
  Osteoarthritis (OA) is the most prevalent degenerative joint disease worldwide and imposes a substantial public health burden due to the lack of effective disease-modifying drugs. Exosome-related genes participate in exosome biogenesis, cargo sorting, and secr…
  pubmed Huang L, Wen Y, Xu H, Zhang Z 等 2026 Aug 25 置信度 0.82
• Gene Genealogies in Haploid Populations Evolving According to Sweepstakes Reproduction.
  Recruitment dynamics, or the distribution of the number of offspring among individuals, is fundamental to ecology and evolution. We take sweepstakes reproduction to mean a skewed (heavy right-tailed) offspring number distribution without natural selection bein…
  pubmed Eldon B 2026 Aug 25 置信度 0.82
• TIMSImaging: An open and interoperable workflow for trapped ion mobility mass spectrometry imaging data processing and visualization.
  Mass spectrometry imaging (MSI) enables high-throughput spatial mapping of molecules, but the lack of chromatographic separation limits its utility for complex biological samples. Ion mobility (IM) provides key orthogonal separation. However, open-source tools…
  pubmed Zhu Y, Bemis K, Lakkimsetty SS, Li MJ 等 2026 Aug 25 置信度 0.82
• A multivariate toolkit for joint articulatory-acoustic analysis with an application to coarticulation.
  This study presents an integrated methodology for analyzing the effects of coarticulation on both articulatory and acoustic properties of phoneme sequences. The approach combines co-registered real-time magnetic resonance imaging (MRI) and acoustic recordings,…
  pubmed Danner T, Moran S, Friedrichs D, Ponce de León MS 等 2026 Aug 1 置信度 0.82
• Structural and functional insights into Pseudomonas aeruginosa ApaH, a diadenosine tetraphosphatase crucial for bacterial virulence.
  Infections by Pseudomonas aeruginosa are a major cause of severe morbidity and mortality in immunocompromised patients and people with cystic fibrosis, largely due to the pathogen's ability to resist antibiotic treatment and to deploy multiple virulence strate…
  pubmed Pistoia G, Cervoni M, Catalano F, Troilo F 等 2026 Sep 置信度 0.82
• Tissue-Agnostic Cellular Morphometric Biomarkers for Risk-Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers.
  While precision oncology increasingly adopts tissue-agnostic paradigms, current strategies remain heavily reliant on molecular alterations, with limited relevance to early-stage cancers and precancerous lesion management. Here we present an unsupervised and in…
  pubmed Wang P, Jiang C, Mao AW, Sun Q 等 2026 Aug 25 置信度 0.82
• Enhanced Immunogenicity and Cross-Neutralizing Activity of a Trivalent Adenoviral Vector-Based SARS-CoV-2 Vaccine in Mice.
  The emergence of diverse SARS-CoV-2 Omicron subvariants has reduced the efficacy of existing vaccines, highlighting the need for multivalent vaccines with broader neutralizing capacity. We developed a trivalent adenoviral vector-based vaccine (Ad5-CoV19-protot…
  pubmed Li J, Song W, Li J, Peng R 等 2026 Aug 置信度 0.82
• Improving annotation, access, and comparison of nutritional composition data for underutilized crops.
  Open and interoperable data infrastructures are essential to advancing food and nutritional security research, yet few data management systems are specifically designed for crop nutritional datasets that support seamless querying, visualization, and comparison…
  pubmed Aboagye A, Shaw PD, Raubach S, Mayes S 等 2026 Jan 15 置信度 0.82
• Regulatory effects and mechanisms of the acupuncture-induced complement component 1q on the high mobility group box 1 -receptor for advanced glycation end products-nuclear factor kappa-B pathway at Zusanli (ST36).
  To investigate what are the crucial regulators and mechanisms involved in regulating the inflammatory responses at Zusanli (ST36).
  pubmed Xiaochun K, Sinuo WU, Ningcen LI, Wenyue XU 等 2026 Aug 置信度 0.82
• Dynamic Predictions and Predictimands for Salvage Therapy in Recurrent Prostate Cancer Using Joint Models.
  Prostate cancer patients with biochemical recurrence (BCR) face a decision of whether to start salvage therapy (ST), which may reduce the probability of metastatic progression at the cost of side effects. To inform the decision to start ST at or after BCR, mod…
  pubmed Owens L, Rizopoulos D, Fainberg J, Carlsson S 等 2026 Sep 置信度 0.82
• Effect of Consecutive Jumping Trials on Metatarsophalangeal, Ankle, Knee and Hip Biomechanics During Take-Off and Landing: A Replication and Extension Study.
  Replication is a fundamental aspect of scientific research, but few replications have been conducted within sports biomechanics yet. The aim of this study was to closely replicate Lam et al. (2021) study, investigating the differences of single and consec…
  pubmed Duchene Y, Hanen NC, Murphy J, Banet L 等 2026 Sep 置信度 0.82
• SeizureBiomeDB: a unified database of gut microbiome alterations in pediatric and adult epilepsy.
  The gut microbiome plays a critical role in health, immunity, metabolism, and brain function. Growing evidence links it to neurological health via the gut-brain axis. Seizure disorders are associated with distinct microbial changes that vary by epilepsy type a…
  pubmed Walji Z, Dave P, Ali M, Negmeldin O 等 2026 置信度 0.82
• Probiotics in Human Health: Current Evidence, Mechanism of Action, and Future Perspectives.
  Probiotics are widely recognized for their potential to promote human health through diverse mechanisms that influence host physiology and microbial ecology. This review synthesizes current evidence on the biological functions, mechanisms of action, and therap…
  pubmed Mulaw G, Kidanemariam G, Bara M, Tesfay T 2026 置信度 0.82
• Transcriptional Profiling of Growth Hormone-Secreting Pituitary Adenoma Stem-Like Cells: Unveiling the Significant Role of CXCR4 in Tumorigenesis and Clinical Applications.
  Growth hormone-secreting pituitary adenoma (GHPA) can cause excessive growth hormone production, which can lead to clinical symptoms such as acromegaly. Tumor stem cells (TSCs) are postulated to play a significant role in the development of GHPA. We performed …
  pubmed Yuan L, Yang H, Li B, Sui H 等 2026 Sep 置信度 0.82
• Microbiome-Driven Risk Stratification and Biotherapeutics in Radiation Enteritis.
  Radiation enteritis (RE) is a severe, dose-limiting complication of cancer radiotherapy that affects the therapeutic outcomes of patients and their quality of life. Current risk assessments primarily rely on physical dosimetry. However, this approach inherentl…
  pubmed Wang Z, Chai Y, Lin T, Zhang Q 等 2026 置信度 0.82
• MRI-Based Deep Learning Guides Multi-Omics Discovery of NBPF4 as a Therapeutic Target for Breast Cancer Lymph Node Metastasis.
  Deep learning models are increasingly used to analyze medical images, but their "black box" nature makes it hard to understand the underlying biology and slows down the development of targeted treatments. To tackle this, we built a multi-step approach that com…
  pubmed Cai D, Huang H, Chen Z, Zhu C 等 2026 置信度 0.82
• Multi-omics analysis of histidine metabolism reveals FRZB-CRYM-associated cellular crosstalk in heart failure.
  The role of histidine metabolism in heart failure (HF), particularly its heterogeneous regulation across cardiac cell types, remains unclear. This study aims to define its mechanistic basis and identify key regulatory genes.
  pubmed Xiao S, Mo C, Liu Q, Xu L 2026 置信度 0.82
• Iodine-mediated 2,5-di(aryl/heteroaryl)-1,3,4-oxadiazoles: synthesis, and in vitro and in silico studies of anticancer and antifungal properties.
  Recent studies have highlighted the 1,3,4-oxadiazole scaffold as an important pharmacophore present in numerous biologically active molecules and therapeutic agents. In continuation of our interest in biologically active heterocyclic compounds, we report the s…
  pubmed Ramesha T, Shenoy TN, Subba Reddy UV, Ega JK 等 2026 Aug 24 置信度 0.82
• Weighted epigenetic site correlation network analysis of chemotherapy impacts on osteosarcoma cancer survivors' male fertility, sperm, and endocrine parameters.
  The impacts of chemotherapy exposure on adolescent male osteosarcoma survivors as adults were investigated using a number of physiological parameters, with a focus on chemotherapy, reproduction, and sperm. The Children's Oncology Group (COG) clinical sites (pr…
  pubmed Shnorhavorian M, Amory JK, Schwartz SM, Bhatia S 等 2026 置信度 0.82
• LAFA: a framework for reproducible longitudinal assessment of protein function annotation models.
  Protein function prediction is a challenging task and an open problem in computational biology. The Critical Assessment of protein Function Annotation (CAFA) is a triennial, community-driven initiative that provides an independent, large-scale evaluation of co…
  pubmed Phan A, Wang Y, Boadu F, Cheng J 等 2026 置信度 0.82
• Artificial intelligence-assisted smart hydrogel bioinks in 3D bioprinting: design, optimization, and construct validation for functional tissue engineering.
  Hydrogel-based bioinks are central to three-dimensional (3D) bioprinting because they provide hydrated, cell-supportive microenvironments with tunable rheological, mechanical, and biological properties. Smart hydrogel bioinks further introduce stimuli-responsi…
  pubmed Zhang S, Liang D, Lei Y, Luo Y 等 2026 置信度 0.82
• Oral corticosteroid dosing strategies for post-COVID-19 organising pneumonia: NORCOVID clinical trial.
  Organising pneumonia is an interstitial lung disease linked to infections and other conditions. Cryptogenic organising pneumonia is a rarer, idiopathic form. Organising pneumonia has become one of the most frequent respiratory complications following severe ac…
  pubmed Espejo-Castellanos D, González-Amezcua A, Pilia MF, Ferreiro-Posse A 等 2026 Jul 置信度 0.82
• Self-identified African ancestry and pathomics-derived tumor-infiltrating lymphocyte scores in colon and rectal adenocarcinoma whole-slide images: an exploratory multicohort whole-slide image study.
  AI assisted computed higher tumor infiltrating lymphocyte% (TIL%) scores from hematoxylin and eosin (H&E) stained whole slide images (WSI) may serve as a useful biomarker for stratifying patients for treatment with immune checkpoint inhibitors.
  pubmed Zhang Y, Cheng X, Liao Y, Adams S 等 2026 置信度 0.82
• Decidua macrophages display a restrained inflammatory profile during chorioamnionitis.
  Decidual macrophages (DMs) are strategically located at the maternal-fetal interface to orchestrate innate host defense while balancing tolerance to the allogenic fetus. An important pregnancy complication is chorioamnionitis characterized by infection/inflamm…
  pubmed Pithia N, Musumarra CV, Protti G, Del Vecchio G 等 2026 置信度 0.82
• Molecular determinants of differential substrate selection between the Src family kinases Lck and Src.
  Src family kinases (SFKs) share highly conserved catalytic domains yet display distinct biological functions, raising the question of how substrate specificity is achieved. Here, we investigate the basis of differential ITAM recognition by Lck and Src, using c…
  pubmed Karpouzou K, D'Abramo M, Grottesi A, Acuto O 等 2026 置信度 0.82
• Combination treatment with intravesical interferon-alpha gene therapy and an oral pan-ErbB receptor family blocker improves survival in mice with bladder cancer.
  Intravesical interferon-alpha (IFNα) gene therapy is approved by the FDA for BCG-unresponsive non-muscle invasive bladder cancer (NMIBC). Identifying resistance mechanisms and deploying targeted combination treatment strategies is a rational approach to …
  pubmed Sood A, Martini A, Genitiano P, Rauf M 等 2026 置信度 0.82
• Pre-expansion downward maxillary base rotation as a biomarker for post-expansion downward maxillary rotation in adults treated with 3D-guided midpalatal piezocorticotomy-assisted MARPE: a pilot case-control study.
  Structural predictors of success or failure in adult maxillary expansion remain poorly defined. This retrospective case-control pilot study aimed to evaluate the predictive capacity of pre-treatment craniofacial morphology-specifically the palatal plane inclin…
  pubmed Koval S, Chepanova D, Stepanoff N, Babii A 等 2026 置信度 0.82
• Brainstem Theory of Consciousness.
  The brainstem theory of consciousness asserts that raw, subjective experience, the "me inside," derives from computations implemented in the brainstem, not the cortex. The argument rests on philosophy's prototypical example of sentience, pain. Feeling pain doe…
  pubmed Devor M, Baron M 2026 Aug 25 置信度 0.82
• AI-powered medicinal chemistry and translational drug development.
  Medicinal chemistry sits at the center of modern drug discovery, yet translating molecular designs into approved medicines remains slow, expensive, and prone to high attrition across the pipeline from target identification to clinical validation. Artificial in…
  pubmed U K, Zhang SM, Yu Z, Zhang Z 等 2026 Aug 25 置信度 0.82
• Targeting the ERK2 Signaling Pathway With Frog Skin-Derived Bioactive Peptides: Insights From Molecular Modeling, Molecular Dynamics, and Physicochemical Features.
  ERK2 plays a vital function in promoting cell survival and proliferation by phosphorylating various substrates. ERK2 is a key druggable target owing to its function in uncontrolled cell proliferation and cancer, making selective ERK2 inhibitors essential for t…
  pubmed Almansour NM, Abdelhamid MMH, Alali Z, Ibrahim MAA 2026 Sep 置信度 0.82
• Practically Error-Free Junctions Enable Solving Large Instances of Exact Cover Problems Using Network-Based Biocomputation.
  Network-based biocomputing (NBC) presents an energy-efficient, parallel computing approach for solving nondeterministic polynomial time (NP) complete problems by leveraging motor-driven cytoskeletal filaments that explore all possible solutions through nanofab…
  pubmed V R EC, Meinecke CR, Nitzsche B, Lyttleton R 等 2026 Aug 24 置信度 0.82
• Association of Combined MET/HGF Expression With the Colorectal Cancer Immune Microenvironment: An Integrated Immunohistochemical and Multi-Database Analysis.
  To validate c-MET protein expression in colorectal cancer (CRC) and assess whether joint MET and hepatocyte growth factor (HGF) transcript expression provides descriptive information on tumor microenvironment features beyond MET alone.
  pubmed Luo S, Guo H, Li X, Long Y 等 2026 Aug 置信度 0.82
• Constant-pH molecular dynamics simulations of closed and open states of a proton-gated ion channel.
  Although traditional molecular dynamics simulations successfully capture a variety of different molecular interactions, the protonation states of titratable residues are kept static. A recent constant-pH molecular dynamics implementation in the GROMACS package…
  pubmed Jansen A, Bauer P, Howard RJ, Hess B 等 2026 Aug 24 置信度 0.82
• Prevalence and Determinants of Anemia among Adolescent Girls in Rural Nepal.
  Adolescence is a period of rapid growth and increased nutritional requirements, making girls in low- and middle-income countries, such as Nepal, vulnerable to iron deficiency anemia. In rural areas of Nepal, menstrual blood loss, poor diet, and socio-cult…
  pubmed Bhandari TR, Chapagain N, Paudel S, Nagila A 等 2026 Aug 3 置信度 0.82
• Rpf-Toxo: A Preliminary Computationally Designed Dense Granule Antigen-Based Multi-Epitope Vaccine Against Toxoplasma gondii.
  Toxoplasma gondii is a protozoan parasite of medical and veterinary importance causing abortion. While current therapies are limited to address the chronic phase of infection, effective prophylactic vaccines are warranted.
  pubmed Safari MH, Hosseini SA, Ghiabi S, Ghiabi S 等 2026 Sep 置信度 0.82
• A Cytochrome P450 Enzyme-Catalyzed Acetyl Migration in Cyanogramide Biosynthesis.
  Cyanogramide (1) is a unique spirooxindole alkaloid derived from a marine actinomycete and is characterized by its distinct spirocyclic pyrrolo[1,2-c]imidazolidin-4-one scaffold. Although we have successfully elucidated the biosynthetic pathway of 1, the mecha…
  pubmed Zhu Y, Wang Y, Zhang L, Fang C 等 2026 Aug 24 置信度 0.82
• Brain-computer interface for upper limb functional recovery post-stroke: a meta-analysis of improvement in upper limb motor function and changes in neurophysiological markers.
  Brain-Computer Interface (BCI) has emerged as a promising intervention, facilitating recovery of upper limb motor function, enhancing associated neurophysiological markers, and improving activities of daily living (ADL) performance, which is measured using the…
  pubmed Zhang H, Xian R, Zhang Y, Liu X 等 2026 Aug 24 置信度 0.82
• Assessment of livestock depredation by hamadryas baboons (Papio hamadryas) in and around Borena-Sayint National Park, northern Ethiopia.
  As human populations expand and natural habitats become increasingly fragmented, the interface between agricultural activities and wilderness areas has become a focal point of ecological tension. Livestock depredation is a prevalent form of human-wildlife conf…
  pubmed Ibrahim H, Bekele A, Yazezew D, Moges A 等 2026 Aug 13 置信度 0.82
• Computational applications in secondary metabolite discovery (CAiSMD) 2026: focus on secondary metabolites towards drug discovery.
  The Computational Applications in Secondary Metabolite Discovery (CAiSMD) 2026 workshop was held from 24 to 26 March 2026 in a hybrid format, combining onsite participation at the University of Buea Center for Drug Discovery with global virtual attendance. Bui…
  pubmed Ntie-Kang F, Betow JY, Eni DB, Metuge JA 等 2026 Aug 24 置信度 0.82
• Pluripotency, differentiation, and reprogramming: 20 years of induced pluripotent stem cells.
  pubmed Hainer SJ, Strawbridge SE, Choi S, Guo G 等 2026 Aug 25 置信度 0.82
• [Teaching reform and practice of a project-based graduate course Bioinformatics in the era of artificial intelligence].
  The rapid development of big data and artificial intelligence (AI) necessitates highly skilled and innovative talents in bioinformatics and the change of conventional teaching for postgraduates. In this study, we identified key challenges in the current teachi…
  pubmed Liao Y, Jiang H, Xu H, He Y 等 2026 Aug 25 置信度 0.82
• [Experimental and computational analyses of altered cetuximab binding induced by EGFR mutations].
  Acquired mutations in the extracellular domain of epidermal growth factor receptor (EGFR) are major causes of cetuximab resistance. However, the structural mechanisms by which different mutations impair antibody binding remain to be clarified. In this study, f…
  pubmed Li Y, Yang H, Zhu J, Wu M 2026 Aug 25 置信度 0.82
• [Rational design and translational applications of hepatitis B virus-like particles].
  Hepatitis B virus-like particles (HBV-VLPs), characterized by precise biomimetic topological architecture and favorable biocompatibility, have become a highly promising cutting-edge carrier in nanomedicine and immune engineering. This article systematically su…
  pubmed Yang Z, Zheng J, DU X, Guan L 等 2026 Aug 25 置信度 0.82
• Standardized Workflow for Long Noncoding RNA Prediction and Expression Profiling in Wheat Under Stem Rust Stress.
  Long noncoding RNAs (lncRNAs), typically over 200 nucleotides in length, with low or no coding capacity, possess significant regulatory roles in plant growth, development, and stress responses by interacting with DNAs, proteins, and other RNAs. This chapter ou…
  pubmed Jyothsna S, Alagu M 2026 置信度 0.82
• FASTA-Fetcher: A Multicolumn Tool for Bulk Retrieval of NCBI Sequences in Plant-Biotic Stress Research.
  Timely and accurate detection of plant pathogens is critical for sustainable agriculture and forestry. Molecular methods enable unequivocal pathogen identification, especially when traditional diagnostics fall short, allowing timely and effective interventions…
  pubmed Ramkrishna, Negi N, Pandey S 2026 置信度 0.82
• An Integrated Computational Method for Investigation of Structural and Functional Impacts of Host-Pathogen Interaction.
  Understanding the mechanisms underlying disease requires detailed insight into host-pathogen interactions. This study presents an integrated computational framework that combines structural bioinformatics and systems biology to analyze the structural and funct…
  pubmed Sahu S, Rashmi M, Sharma S, Sachdeva N 等 2026 置信度 0.82
• Beyond benchmarking: an expert-guided consensus approach to spatially aware clustering.
  Spatial omics technologies have revolutionized the study of tissue architecture and cellular heterogeneity by integrating molecular profiles with spatial localization. In spatially resolved transcriptomics, delineating higher-order anatomical structures is cri…
  pubmed Sun J, Biharie K, Cai P, Müller-Bötticher N 等 2026 Aug 24 置信度 0.82
• Measuring surprisal in sound sequences.
  Sensory input that violates prior expectations attracts attention, making unpredictability an important perceptual property to measure. In the auditory modality, knowing what sounds will be perceived as surprising, and therefore salient, is relevant both for s…
  pubmed Anikin A 2026 Aug 24 置信度 0.82
• Beyond the flat screen: evaluating virtual reality as a complementary tool for molecular docking in drug discovery.
  Molecular docking is a key computational approach in drug discovery and structural biology. Traditional docking tools, while effective for high-throughput screening, often rely on rigid or semiflexible receptor models and purely algorithmic sampling, limiting …
  pubmed Feoktistova VA, Aruko K, Skorb EV, Shityakov S 2026 Aug 24 置信度 0.82
• Outcomes of restorative proctectomy and ileal pouch-anal anastomosis: a matched-cohort analysis of robot-assisted, laparoscopic, and open surgery.
  Ileal pouch-anal anastomosis (IPAA) remains the gold standard for restorative proctocolectomy, yet its technical complexity has limited widespread minimally invasive adoption. Robotic surgery was introduced to overcome the ergonomic and visualization challenge…
  pubmed Violante T, Cardelli S, Romano A, Tiano A 等 2026 Aug 24 置信度 0.82
• Motor neurons organize Drosophila feeding sequences via a disinhibitory cascade.
  Classical models view motor neurons as the final relays of commands driving behaviors such as breathing and feeding. Here, in simultaneous quadruple-electrode recordings from Drosophila performing feeding behavior, we demonstrate that the relevant motor neuron…
  pubmed Sui XW, Yi JJ, Zhou Y, Wang YL 等 2026 Aug 24 置信度 0.82
• Obligate cross-feeding of metabolites is common in soil microbial communities.
  Ecological theory predicts that obligate cross-feeding of metabolites is common in microbial communities. However, systematic studies testing this prediction in natural microbial communities such as soil are missing, thus hindering the understanding of these e…
  pubmed Yousif G, Zorrilla F, Dash S, Oña L 等 2026 Sep 置信度 0.82
• High-throughput in silico multi-epitope reverse vaccine design against hydatidosis.
  The Middle East is a significant hotspot for human hydatidosis caused by Echinococcus granulosus, a complex multi-stage pathogen exhibiting antigenic variation with diverse epitopes. Multi-epitope vaccines, designed using immunoinformatics, represent a promisi…
  pubmed Skhal D, Al Nahhas S, Skhal O, Abbady AQ 2026 Aug 11 置信度 0.82
• PotatoRTD and TomatoRTD: Comprehensive Reference Transcript Datasets for Accurate Transcriptome Analysis and Isoform Discovery.
  Transcriptome annotations provide essential information on transcript locations, sequences and structures, including transcription start, end sites and splice junctions. They underpin key biological analyses such as gene and transcript quantification, and the …
  pubmed Guo W, Milne L, Lopez-Gomollon S, Kaur A 等 2026 Aug 24 置信度 0.82
• Enabling molecular signaling with temperature and ionic-strength independence or programmable dependence.
  The equilibrium constants of chemical reactions fundamentally depend on temperature, posing challenges for living systems. However, many conformer organisms do not maintain a stable internal temperature. This raises the question: can molecular signaling pathwa…
  pubmed Korenkov ES, Nikitin MP 2026 Aug 7 置信度 0.82
• Inhibition of cyclin-dependent kinase 8 modulates chondrocyte transition to hypertrophy and provides in vivo protection against spontaneous osteoarthritis.
  Chondrocyte hypertrophy is a key hallmark of osteoarthritis (OA) that drives a multitude of whole-joint disease processes. There are no approved disease-modifying pharmaceuticals in clinical use, emphasising the urgent need for innovative therapeutics. Screeni…
  pubmed Wells LM, Keen JAC, Sharma A, Marr N 等 2026 Aug 25 置信度 0.82
• Computational exploration of phycobiliproteins-derived peptides: in-silico gastrointestinal digestion and multi-target molecular docking against Alzheimer's disease-related enzymes.
  Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by amyloid-β (Aβ) accumulation, Tau hyperphosphorylation, and cholinergic dysfunction, necessitating multi-target therapeutic strategies. This study evaluated phy…
  pubmed Lijassi I, Mansouri Z, Rhazi L, Wahby I 2026 Aug 24 置信度 0.82
• Complex enzymolysis-derived peanut peptides: in silico selection of antioxidant peptides, emulsion-microcapsule encapsulation, and in vitro digestive performance evaluation.
  Peanut peptides (PP) are promising plant-derived functional ingredients, but bitterness and gastrointestinal instability limit oral applications. This study integrated complex enzymolysis, LC-MS/MS-assisted in silico screening, molecular dynamics (MD), and W 1…
  pubmed Jia C, Wang Y, Ran T, Gong Z 等 2026 Oct 31 置信度 0.82
• Advancements in the research of antioxidant peptides: A comprehensive overview.
  Oxidative stress can trigger apoptosis, tissue damage, and the onset of various chronic diseases. By maintaining cellular homeostasis, antioxidants can effectively reduce the risk of diseases associated with oxidative damage, including cardiovascular diseases,…
  pubmed Bai X, Pan W, Xu M, Rafiq M 等 2026 Oct 31 置信度 0.82
• Machine learning-assisted spectroscopic approaches for pesticide residue detection in food matrices.
  The widespread use of pesticides in modern agriculture has substantially improved food production while raising serious concerns regarding contamination and food safety. Considerable scientific effort has focused on improving methods for monitoring and detecti…
  pubmed Ezenwanne BC, Okoye CO, Abhadiomhen SE, Aham EC 等 2026 Oct 31 置信度 0.82
• Evaluating the potential of foodborne chemicals to modulate intestinal barrier function: a combined in vitro/in silico toolbox to study the effects on tight junction protein claudin-4.
  Intestinal barrier integrity is of paramount importance for our health. Several food constituents and contaminants have been described for positive or detrimental effects, however, a correlation between gut associated disorders and xenobiotics exposures remain…
  pubmed Bergen J, Fellinger C, Weinstabl M, Jobst M 等 2026 Oct 31 置信度 0.82
• Theory-driven computational psychiatry and its challenges: An optimistic outlook.
  Mental health disorders affect millions worldwide, yet our understanding of their underlying mechanisms remains limited, impeding the development of precise and effective treatments. Computational psychiatry, a burgeoning field at the intersection of neuroscie…
  pubmed Fisher EL, Sajid N, Convertino L, Hohwy J 2026 Aug 27 置信度 0.82
• Topographic gradients of resting-state EEG alpha asymmetry: Network-specific lateralization and age-related dedifferentiation in healthy adults.
  Alpha asymmetry, which quantifies hemispheric differences in alpha power (8-13 Hz), serves as a neurophysiological marker of cortical activation. While frontal alpha asymmetry has been extensively studied in affective disorders, full topographic character…
  pubmed Caravaglios G, Caravaglios L, Vestini MA, Di Maria G 等 2026 Aug 24 置信度 0.82
• Living drug carriers: Microbial and bioengineered platforms redefining precision therapeutic and immunomodulatory delivery.
  Microbial living therapeutics are a new class of drug-delivery materials that combine synthetic biology, immunomodulation, and advanced formulations to achieve controllable therapeutic effects in space and time. In the broad field of living drug-delivery syste…
  pubmed Guha L, Malik JA, Bose B 2026 Aug 24 置信度 0.82
• An inherited hypomorphic variant in PIEZO2 reveals structural features of mechanotransduction.
  PIEZO2 is the principal mechanosensory channel for proprioception, touch, and many interoceptive processes, yet key details of how PIEZO channels convert force into electrochemical signals remain unclear. Here, we report fraternal twins with proprioceptive ata…
  pubmed Nickolls AR, Mulhall EM, Orlin DJ, Yarishkin O 等 2026 Aug 24 置信度 0.82
• Explainable spatio-temporal transformers for schizophrenia classification and activity analysis from functional MRI.
  Schizophrenia is a complicated neuropsychiatric disorder caused by disturbed brain connectivity and abnormal neural activation patterns. To identify these underlying neural mechanisms, computational models need to be reliable and interpretable to support objec…
  pubmed Sarveswaran T, Rajangam V 2026 Aug 20 置信度 0.82
• New insights into multi-endpoint toxicological profiles and potential molecular mechanisms for display-related organic light-emitting/modulating materials.
  Display-related organic light-emitting/modulating materials (DOLMs) are increasingly detected in the environment, raising growing health concerns. However, toxicological data remain available for only a limited number of DOLMs, and their toxicity and underlyin…
  pubmed Tang M, Wu W, Wang Y, Liu X 等 2026 Aug 24 置信度 0.82
• Bacterial dehalogenases for organohalide and organofluorine remediation: Mechanistic insights, evidence gaps, and future relevance to GenX treatment.
  Bacterial dehalogenase enzymes catalyze the cleavage of carbon-halogen bonds and play important roles in the microbial transformation of many halogenated contaminants. This review critically examines major classes of bacterial dehalogenases, including haloalka…
  pubmed Kontoh DB, Deng D, Fu H, Lamssalli M 2026 Aug 24 置信度 0.82
• Omitting Bone Marrow Sampling in FDG-Avid Rhabdomyosarcoma With 2-[(18)F]FDG PET-Negative Marrow: Results From an International Retrospective Study.
  Detection of bone marrow disease has been a major component of rhabdomyosarcoma (RMS) staging with bilateral bone marrow aspirates/biopsies (BMAB) from the iliac crests considered the diagnostic gold standard. This study's goal was to determine if 2- 18 F-labe…
  pubmed Mercolini F, Just M, Shulkin BL, Collins NB 等 2026 Aug 24 置信度 0.82
• HLA class I escape drives the evolution of SARS-CoV-2 in human populations.
  The role of escape from the cytotoxic T cell (CTL) response in Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation…
  pubmed Riumina ED, Alekseeva EI, Klink GV, Feigin S 等 2026 Sep 置信度 0.82
• The role of chloride ions in serotonin transport.
  The human serotonin (5-HT + ) transporter SERT facilitates 5-HT + transport into cells by coupling it to Na + symport and K + antiport. Although extracellular Cl - is also essential for transport, Cl - cotransport has been disputed, raising questions about the…
  pubmed Huang J, Backer A, Uchendu S, Bekele B 等 2026 Sep 置信度 0.82
• Shifting gears to power human walking.
  The musculoskeletal system features an abundance of functionally similar muscles, yet the performance benefits of this apparent redundancy remain unclear. Here, we show that muscles with similar function, but distinct moment arms, facilitate a dynamic gear-shi…
  pubmed Martin JA, Welte L, Knurr KA, Thelen DG 2026 Sep 8 置信度 0.82
• Assessment of CD3+ T cell density in the intestinal mucosa of dogs with inflammatory bowel disease.
  T lymphocytes play a central role in the intestinal immune response in dogs with immunomodulator-responsive enteropathy (IRE), but the clinical relevance of mucosal T-cell infiltration remains unclear.
  pubmed Bouillet G, Méric T, Gonel G, Darnis E 等 2026 Jul 1 置信度 0.82
• Replication-transcription collisions impose DNA strand-specific constraints on gene length in bacteria.
  Gene length is a peculiar genomic feature that exhibits minimal variation within domains of life, suggesting universal underlying constraints. The length of a gene is primarily influenced by its function, expression level, and mutation risk. Interestingly, man…
  pubmed Variyar A, Patil S, Babu J, Bhat A 等 2026 Aug 置信度 0.82
• Exome-based cancer driver gene comprehensive testing can provide a genetic diagnosis for individuals with triple-negative breast cancer.
  Triple-negative breast cancer (TNBC) is characterized by aggressive behaviour, high tumor heterogeneity, and an increased likelihood of recurrence and early metastasis. These factors hinder successful treatment. Genetic diagnosis enables personalized clinical …
  pubmed Alzate D, Sánchez AY, Pacheco Y, Isaza Ruget M 等 2026 置信度 0.82
• Systematic analysis of global O-serotype prevalence of neonatal extraintestinal pathogenic Escherichia coli: A protocol integrating previous research and bioinformatics databases.
  Neonatal extraintestinal pathogenic Escherichia coli (ExPEC) severe threat to newborn health. O antigen is a highly variable component of lipopolysaccharide, serves as the main phenotypic marker for serotyping, and represents a promising target for vaccination…
  pubmed Zhang D, Zou P, Xiao R, Li J 等 2026 置信度 0.82
• Shear wave propagation in a prestressed and transversely isotropic viscoelastic material: Inverse modeling challenges and strategies.
  The functional role and structure of some biological tissues, such as skeletal muscle, result in anisotropy in both material properties and imposed stresses. Dynamic elastography reconstruction methods for estimating soft tissue viscoelastic properties that ar…
  pubmed Vorobyeva A, Wang Q, Klatt D, Ludvig D 等 2026 Aug 1 置信度 0.82
• Protocol to characterize tumor microenvironment in a diffuse midline glioma mouse model using multi-omics approach on sequential sections.
  Diffuse midline glioma (DMG) tumors form complex tumor-immune microenvironments with marked cellular heterogeneity. Here, we present a protocol to generate orthotopic DMG tumors in immunocompetent neonatal mice and to spatially characterize the tumor ecosystem…
  pubmed Collot R, Honhoff C, Ruiz-Moreno C, van Ineveld RL 等 2026 Aug 24 置信度 0.82
• Sexual dimorphisms in mechanisms of pressure natriuresis.
  Aim: The renal pressure-natriuresis response defines the blood pressure set point and maintains circulating volume. In male rats, the mechanisms involve trafficking and inactivation of renal proximal sodium transporters. Mechanisms may differ in females due to…
  pubmed McFarlin BE, Ralph DL, Koepsell H, Layton AT 等 2026 Aug 24 置信度 0.82
• Optimising the tilt increment for in situ cryo-electron tomography.
  Cryo-electron tomography (cryo-ET) enables high-resolution, three-dimensional imaging of cellular structures in their native, frozen state. However, image quality is limited by a trade-off between angular sampling and radiation damage. Therefore, the choice of…
  pubmed Tuijtel MW, Majtner T, Turoňová B, Beck M 2026 Aug 24 置信度 0.82
• miRSiC: a regulatory-aware machine learning framework for microRNA expression inference across bulk and single-cell transcriptomes.
  MicroRNAs (miRNAs) are key post-transcriptional regulators embedded in gene regulatory networks between upstream transcription factors (TFs) and downstream target genes (TGs), yet most computational approaches infer miRNA expression using unstructured transcri…
  pubmed Chen GT, Liang LC, Tang Y, Chen YC 等 2026 Jul 3 置信度 0.82
• DeepPANB: integrating protein language model with PaiNN equivariant graph neural networks for prediction of protein-nucleic acid binding sites.
  Protein-nucleic acid interactions are fundamental to various biological processes, and accurately identifying nucleic acid binding sites on proteins is essential for understanding gene regulation mechanisms and advancing drug design. Here, we present DeepPANB,…
  pubmed Zhang J, Wu Z, Su J, Zhang X 等 2026 Jul 3 置信度 0.82
• GLMYsymm: inferring symmetry categories of protein complexes from single sequences using persistent GLMY homology.
  Proteins often perform essential biological functions in the form of complexes. The assembly of protein complexes typically exhibits symmetry, which contributes to a more stable structural organization. Therefore, investigating structural symmetry is of great …
  pubmed Zhai J, Li J, Yau ST, Gong X 2026 Jul 3 置信度 0.82
• Dual-SVF: a robust knowledge-guided multimodal method for structural variant filtering in long-read sequencing.
  Structural variants (SVs) are key drivers of genomic diversity and disease, yet their accurate detection from long-read sequencing remains challenged by high false-positive rates caused by sequencing errors and alignment artifacts. Current filtering approaches…
  pubmed Lai C, Zhang H, Cheng C, Peng J 等 2026 Jul 3 置信度 0.82