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• A sex-informed approach to improve the personalised decision making process in myelodysplastic syndromes: a multicentre, observational cohort study
  BACKGROUND: Sex is a major source of diversity among patients and a sex-informed approach is becoming a new paradigm in precision medicine. We aimed to describe sex diversity in myelodysplastic syndromes in terms of disease genotype, phenotype, and clinical ou…
  openalex Giulia Maggioni, Matteo Bersanelli, Erica Travaglino, Ana Alfonso Piérola 等 2022-11-25 置信度 0.72 MedicineMyelodysplastic syndromesCohortObservational studyPopulation
• Avian influenza overview March–June 2025
  Abstract Between 8 March and 6 June 2025, 365 highly pathogenic avian influenza (HPAI) A(H5) virus detections were reported in domestic (167) and wild (198) birds across 24 countries in Europe. HPAI A(H5N1) virus detections were predominant and mainly located …
  openalex European Food Safety Authority, Leonidas Alexakis, Hubert Buczkowski, Mariette Ducatez 等 2025-07-01 置信度 0.72 Influenza A virus subtype H5N1WaterfowlVeterinary medicineHighly pathogenicInfluenza A virus
• Genomic and Expression Analyses Identify a Disease-Modifying Variant for Fibrostenotic Crohn’s Disease
  Background and Aims: Crohn's disease [CD] is a chronic inflammatory disease with unpredictable behaviour. More than half of CD patients eventually develop complications such as stenosis, for which they then require endoscopic dilatation or surgery, as no anti-…
  openalex Marijn C. Visschedijk, Lieke M. Spekhorst, Shih‐Chin Cheng, Ellen S. van Loo 等 2018-01-16 置信度 0.72 WWOXSingle-nucleotide polymorphismSNPCrohn's diseaseAllele
• Technical note: Comparative analyses of the quality and yield of genomic DNA from invasive and noninvasive, automated and manual extraction methods
  Several new automated methods have recently become available for high-throughput DNA extraction, including the Maxwell 16 System (Promega UK, Southampton, UK). The purpose of this report is to compare automated with manual DNA extraction methods, and invasive …
  openalex Cathriona Foley, Cliona O’Farrelly, Kieran G. Meade 2011-05-25 置信度 0.72 DNA extractionSemenBuffy coatExtraction (chemistry)DNA
• Ecological connectivity of genomic markers of antimicrobial resistance in Escherichia coli in Hong Kong
  Antibiotic-resistant Escherichia coli (E. coli) is a major contributor to the global burden of antimicrobial resistance (AMR). While the One Health concept emphasizes the connection of human, animal, and environmental health, genome-resolved and quantitatively…
  openalex Xiaoqing Xu, Yunqi Lin, Yu Deng, Lei Liu 等 2025-08-08 置信度 0.72 BiologyAntibiotic resistancePlasmidEscherichia coliGenome
• A nationwide comprehensive genomic profiling and molecular tumor board platform for patients with advanced cancer
  The Belgian Approach for Local Laboratory Extensive Tumor Testing (BALLETT) study assessed the feasibility of using comprehensive genomic profiling (CGP) in clinical decision-making for patients with advanced cancers. This multi-center study enrolled 872 patie…
  openalex Pieter‐Jan Volders, Philippe Aftimos, Franceska Dedeurwaerdere, Geert A. Martens 等 2025-03-10 置信度 0.72 MedicineStandardizationOncologyProfiling (computer programming)Turnaround time
• Genomic landscape and preclinical models of angiosarcoma
  Angiosarcoma is a cancer that develops in blood or lymphatic vessels that presents a significant clinical challenge due to its rarity and aggressive features. Clinical outcomes have not improved in decades, highlighting a need for innovative therapeutic strate…
  openalex Annaleigh Benton, Bozhi Liu, Lauren E. Gartenhaus, Jason A. Hanna 2024-10-05 置信度 0.72 AngiosarcomaDiseaseComputational biologyBiologyMedicine
• Genomic epidemiology and antifungal resistance of emerging Trichophyton indotineae in China
  Trichophyton indotineae is an emerging pathogenic fungus of growing concern due to its drug resistance and therapeutic challenges posing to dermatophytosis [1, 2]. Initially classified as T. mentag...
  openalex Wenting Xie, Guanzhao Liang, Xue Kong, Clement K. M. Tsui 等 2025-04-28 置信度 0.72 EpidemiologyChinaBiologyAntifungalResistance (ecology)
• Current Status of Cancer Genomics and Imaging Phenotypes: What Radiologists Need to Know
  Ongoing discoveries in cancer genomics and epigenomics have revolutionized clinical oncology and precision health care. This knowledge provides unprecedented insights into tumor biology and heterogeneity within a single tumor, among primary and metastatic lesi…
  openalex Eva Serrão, Maximiliano Klug, Brian Moloney, Aaditeya Jhaveri 等 2023-11-01 置信度 0.72 RadiogenomicsMedicineGenomicsPrecision medicineEpigenomics
• Longitudinal population-level HIV epidemiologic and genomic surveillance highlights growing gender disparity of HIV transmission in Uganda
  HIV incidence in eastern and southern Africa has historically been concentrated among girls and women aged 15-24 years. As new cases decline with HIV interventions, population-level infection dynamics may shift by age and gender. Here, we integrated population…
  openalex Mélodie Monod, Andrea Brizzi, Ronald M. Galiwango, Robert Ssekubugu 等 2023-12-05 置信度 0.72 Incidence (geometry)Transmission (telecommunications)DemographyMedicinePopulation
• Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice1
  1,25-Dihydroxyvitamin D3 plays a major role in intestinal calcium transport. To determine what phenotypic abnormalities observed in vitamin D receptor (VDR)-ablated mice are secondary to impaired intestinal calcium absorption rather than receptor deficiency, m…
  openalex Yan Chun Li, Michael Amling, Alison E. Pirro, Matthias Priemel 等 1998-10-01 置信度 0.72 Calcitriol receptorEndocrinologyInternal medicineOsteomalaciaRickets
• Characterization of pDJA1, a cardiac-specific chaperone found by genomic profiling of the post-ischemic swine heart
  BACKGROUND: Previously, we showed by subtractive hybridization in a swine model of ischemia/reperfusion that an upregulation of genes participating in mechanisms of cell survival is a potential genomic mechanism to tilt the balance from necrosis to functional …
  openalex C. Depre, Lu Wang, J TOMLINSON, Vinciane Gaussin 等 2003-04-01 置信度 0.72 Suppression subtractive hybridizationMyocyteVentricleEndocardiumBiology
• Genomic and proteomic analysis of transcription factor TFII-I reveals insight into the response to cellular stress
  The ubiquitously expressed transcription factor TFII-I exerts both positive and negative effects on transcription. Using biotinylation tagging technology and high-throughput sequencing, we determined sites of chromatin interactions for TFII-I in the human eryt…
  openalex Alex Xiu‐Cheng Fan, Giorgio L. Papadopoulos, Mir Ahamed Hossain, I‐Ju Lin 等 2014-05-29 置信度 0.72 BiologyTranscription factorTranscription (linguistics)Molecular biologyATF3
• How Do Cold-Adapted Plants Respond to Climatic Cycles? Interglacial Expansion Explains Current Distribution and Genomic Diversity in Primula farinosa L.
  Understanding the effects of past climatic fluctuations on the distribution and population-size dynamics of cold-adapted species is essential for predicting their responses to ongoing global climate change. In spite of the heterogeneity of cold-adapted species…
  openalex Spyros Theodoridis, Christophe F. Randin, Péter Szövényi, Florian C. Boucher 等 2016-12-14 置信度 0.72 InterglacialBiologyClimate changeEcologyPopulation
• A genomic history of the North Pontic Region from the Neolithic to the Bronze Age
  The North Pontic Region was the meeting point of the farmers of Old Europe and the foragers and pastoralists of the Eurasian steppe1,2, and the source of migrations deep into Europe3–5. Here we report genome-wide data from 81 prehistoric North Pontic individua…
  openalex Alexey G. Nikitin, Iosif Lazaridis, Nick Patterson, Світлана Іванова 等 2025-02-05 置信度 0.72 Bronze AgeBronzeArchaeologyAncient historyGeography
• Functional and genomic analyses of plant growth promoting traits in Priestia aryabhattai and Paenibacillus sp. isolates from tomato rhizosphere
  This study investigated plant growth-promoting (PGP) mechanisms in Priestia aryabhattai VMYP6 and Paenibacillus sp. VMY10, isolated from tomato roots. Their genomes were initially assessed in silico through various approaches, and these observations were then …
  openalex Carolina Almirón, Tomás Denis Petitti, María Agustina Ponso, Ana María Romero 等 2025-01-28 置信度 0.72 RhizosphereBiologyPaenibacillusBotanyPlant growth
• Genomic Profiling to Contextualize the Results of Intervention for Smoldering Multiple Myeloma
  PURPOSE: Early intervention for high-risk smoldering multiple myeloma (HR-SMM) achieves deep and prolonged responses. It is unclear if beneficial outcomes are due to the treatment of less complex, susceptible disease or inaccuracy in clinical definition of cas…
  openalex Dickran Kazandjian, Benjamin Diamond, Marios Papadimitriou, Elizabeth Hill 等 2024-04-23 置信度 0.72 Multiple myelomaProfiling (computer programming)BiologyMedicineComputational biology
• Integrating Genomics, Radiomics, and Pathomics in Oncology: A Scoping Review and a Framework for AI-Enabled Surgomics
  BACKGROUND: Multimodal AI integration across genomics, radiomics, and pathomics is rapidly evolving in oncology, but evidence remains heterogeneous and unevenly distributed across modalities. OBJECTIVE: To map empirical studies integrating two or more -omic mo…
  openalex Selma Mtoor, Niki Rashidian, Nouredin Messaoudi, Vincent Grasso 等 2026-01-20 置信度 0.72 WorkflowProcess managementComputer scienceKnowledge managementSystems engineering
• Which Individuals To Choose To Update the Reference Population? Minimizing the Loss of Genetic Diversity in Animal Genomic Selection Programs
  Genomic selection (GS) is commonly used in livestock and increasingly in plant breeding. Relying on phenotypes and genotypes of a reference population, GS allows performance prediction for young individuals having only genotypes. This is expected to achieve fa…
  openalex Sonia E Eynard, Pascal Croiseau, Dénis Laloë, Sébastien Fritz 等 2017-11-14 置信度 0.72 PopulationGenetic diversitySelection (genetic algorithm)Genetic gainTrait
• Cloning of Mouse Type VII Collagen Reveals Evolutionary Conservation of Functional Protein Domains and Genomic Organization
  openalex Sirpa Kivirikko, Sirpa Kehua Li, Angela M. Christiano, Jouni Uitto 1996-06-01 置信度 0.72 Anchoring fibrilsExonBiologyGeneIntron
• Widespread Discordance of Gene Trees with Species Tree in Drosophila: Evidence for Incomplete Lineage Sorting
  The phylogenetic relationship of the now fully sequenced species Drosophila erecta and D. yakuba with respect to the D. melanogaster species complex has been a subject of controversy. All three possible groupings of the species have been reported in the past, …
  openalex Daniel A. Pollard, Venky N. Iyer, Alan M Moses, Michael B. Eisen 2006-10-25 置信度 0.72 Coalescent theoryBiologyPhylogenetic treeLineage (genetic)Evolutionary biology
• Insights into ecology, pathogenesis, and biofilm formation of Enterococcus faecalis from functional genomics
  SUMMARY Enterococcus faecalis is a significant resident of the gastrointestinal tract of most animals, including humans. Although generally non-pathogenic in healthy hosts, this microbe is adept at the exploitation of compromises in host immune functions, resu…
  openalex Julia L. E. Willett, Gary M. Dunny 2024-12-23 置信度 0.72 BiologyEnterococcus faecalisOrganismModel organismGenomics
• Evolving concepts in meningioma management in the era of genomics
  Meningioma is the most common type of primary brain tumor. Surgical resection followed by surveillance is the first-line treatment for the majority of symptomatic meningiomas; however, recent advances in molecular sequencing, DNA methylation, proteomics, and s…
  openalex Annie L. Hsieh, Wenya Linda Bi, Vijaya Ramesh, Priscilla K. Brastianos 等 2024-05-16 置信度 0.72 MedicineMeningiomaGenomicsDNA methylationDNA sequencing
• Outcomes of 4 years of molecular genetic diagnosis on a panel of genes involved in premature aging syndromes, including laminopathies and related disorders
  BACKGROUND: Segmental progeroid syndromes are a heterogeneous group of rare and often severe genetic disorders that have been studied since the twentieth century. These progeroid syndromes are defined as segmental because only some of the features observed dur…
  openalex Maude Grelet, Véronique Blanck, Sabine Sigaudy, Nicole Philip 等 2019-12-01 置信度 0.72 Human geneticsPremature agingGeneGeneticsMedicine
• Satellite DNA Genomics: The Ongoing Story
  Tandemly repeated non-coding sequences, widely known as satellite DNAs (satDNAs), are extremely diverse and highly variable components of eukaryotic genomes. In recent years, advances in high-throughput sequencing and new bioinformatics platforms have enabled …
  openalex Manuel A. Garrido-Ramos, Miroslav Plohl, Eva Šatović 2025-11-22 置信度 0.72 HeterochromatinTandem repeatBiologyComputational biologySatellite DNA
• Novel Highly Pathogenic Avian Influenza A(H5N1) Virus, Argentina, 2025
  Genomic sequencing of reemerging highly pathogenic avian influenza A(H5N1) virus detected in Argentina in February 2025 revealed novel triple-reassortant viruses containing gene segments from Eurasian H5N1 and low pathogenicity viruses from South and North Ame…
  openalex Ralph Eric Thijl Vanstreels, Martha I. Nelson, Carolina Artuso, Vanina Daniela Marchione 等 2025-12-01 置信度 0.72 Influenza A virus subtype H5N1Highly pathogenicBiologyCladeVirology
• Voluntary workplace genomic testing: wellness benefit or Pandora’s box?
  Consumer interest in genetic and genomic testing is growing rapidly, with more than 26 million Americans having purchased direct-to-consumer genetic testing services. Capitalizing on the increasing comfort of consumers with genetic testing outside the clinical…
  openalex Kunal Sanghavi, Betty Cohn, Anya E. R. Prince, W Feero 等 2022-01-20 置信度 0.72 Genetic testingAppealBusinessCorporate governanceMarketing
• Genomic perspectives on foodborne illness
  Whole-genome sequencing of bacterial pathogens is used by public health agencies to link cases of food poisoning caused by the same source of contamination. The vast majority of these appear to be sporadic cases associated with small contamination episodes and…
  openalex David J. Lipman, Joshua L. Cherry, Strain Errol, Richa Agarwala 等 2024-11-05 置信度 0.72 SalmonellaCampylobacterContaminationBiologyContaminated food
• The clinical outcomes and genomic landscapes of acute lymphoblastic leukemia patients with E2A‐PBX1 : A 10‐year retrospective study
  The clinical outcomes and genomic features of E2A-PBX1 (TCF3-PBX1)-positive B-cell acute lymphoblastic leukemia (B-ALL) patients remain unclear. A total of 137 patients carrying E2A-PBX1 among 3164 B-ALL patients between 2009 and 2019 were retrospectively anal…
  openalex Biqi Zhou, Xinran Chu, Hong Tian, Tianhui Liu 等 2021-08-18 置信度 0.72 Lymphoblastic LeukemiaMedicineRetrospective cohort studyOncologyInternal medicine
• Perspective on recent developments and challenges in regulatory and systems genomics
  : Predicting how genetic variation affects phenotypic outcomes at the organismal, cellular, and molecular levels requires deciphering the cis-regulatory code, the sequence rules by which non-coding regions regulate genes. In this perspective, we discuss recent…
  openalex Julia Zeitlinger, Sushmita Roy, Ferhat Ay, Anthony Mathelier 等 2024-12-26 置信度 0.72 GenomicsBenchmarkingComputational biologyRegulatory sequenceGene regulatory network
• ULTRA-effective labeling of tandem repeats in genomic sequence
  Abstract In the age of long read sequencing, genomics researchers now have access to accurate repetitive DNA sequence (including satellites) that, due to the limitations of short read-sequencing, could previously be observed only as unmappable fragments. Tools…
  openalex Daniel R. Olson, Travis J. Wheeler 2024-01-01 置信度 0.72 Tandem repeatSequence (biology)Computational biologyVariable number tandem repeatGenetics
• BioGPT: A Generative Transformer-Based Framework for Personalized Genomic Medicine and Rare Disease Diagnosis
  This paper introduces BioGPT, a generative transformer-based framework designed to advance personalized genomic medicine and rare disease diagnosis. Unlike conventional models that process either genomic sequences or clinical narratives in isolation, BioGPT em…
  openalex Ghada Al-Kateb, Emine Cengiz, Murat Gök 2025-07-11 置信度 0.72 Generative grammarPersonalized medicineTransformerGenomic medicineComputer science
• Optimising Sampling Design for Landscape Genomics
  Landscape genomic approaches for detecting genotype-environment associations (GEA), isolation by distance (IBD) and isolation by environment (IBE) have seen a dramatic increase in use, but there have been few thorough analyses of the influence of sampling stra…
  openalex Anusha P. Bishop, Drew E. Terasaki Hart, Ian Wang 2024-12-17 置信度 0.72 Sampling (signal processing)BiologyTransectIsolation by distanceGenomics
• Data reuse in agricultural genomics research: challenges and recommendations
  The scientific community has long benefited from the opportunities provided by data reuse. Recognizing the need to identify the challenges and bottlenecks to reuse in the agricultural research community and propose solutions for them, the data reuse working gr…
  openalex Alenka Hafner, Victoria L. DeLeo, Cecilia Deng, Christine G. Elsik 等 2025-01-01 置信度 0.72 GenomicsData scienceReuseAgricultureComputer science
• Cell cycle regulation of the human cdc2 gene.
  openalex Stephen Dalton 1992-05-01 置信度 0.72 BiologyCyclin-dependent kinase 1E2FGeneTranscription (linguistics)
• Expanding the genomic diversity of human anelloviruses
  Abstract Anelloviruses are a group of small, circular, single-stranded DNA viruses that are found ubiquitously across mammalian hosts. Here, we explored a large number of publicly available human microbiome datasets and retrieved a total of 829 anellovirus gen…
  openalex Sejal Modha, Joseph Hughes, Richard Orton, Spyros Lytras 2025-01-01 置信度 0.72 BiologyGenomeRecombinationHomologous recombinationGenetics
• Genos: a human-centric genomic foundation model
  BACKGROUND: The rapid expansion of human genomic data demands foundation models that manage ultra-long sequences and capture population diversity, limitations common in existing models that lack human-specific representation, and clinical inference efficiency.…
  openalex Anqi Lin, Bin Xie, Ye Cheng, Cheng Wang 等 2025-01-01 置信度 0.72 BlueprintDocumentationFoundation (evidence)Benchmark (surveying)Computer science
• Precision Neuro-Oncology in Glioblastoma: AI-Guided CRISPR Editing and Real-Time Multi-Omics for Genomic Brain Surgery
  Precision neurosurgery is rapidly evolving as a medical specialty by merging genomic medicine, multi-omics technologies, and artificial intelligence (AI) technology, while at the same time, society is shifting away from the traditional, anatomic model of care …
  openalex Matei Șerban, Corneliu Toader, Răzvan-Adrian Covache-Busuioc 2025-07-30 置信度 0.72 Precision medicineOmicsGenomicsPersonalized medicineComputational biology
• Triazole-resistant Aspergillus fumigatus in the Netherlands between 1994 and 2022: a genomic and phenotypic study
  Background Aspergillus fumigatus is the main cause of invasive aspergillosis and triazole antifungals are the primary treatment option. The effectiveness of triazole therapy is hampered by the emergence of resistance, mainly caused by mutations in the cyp51A g…
  openalex Yinggai Song, Jochem B. Buil, Johanna Rhodes, Jan Zoll 等 2025-07-15 置信度 0.72 Aspergillus fumigatusGenotypeBiologyMicrobiologyTriazole
• Origins of chromosome instability unveiled by coupled imaging and genomics
  , the underlying processes and rates of spontaneous CA formation in human cells are underexplored. Here we introduce machine-learning-assisted genomics and imaging convergence (MAGIC)-an autonomously operated platform that integrates live-cell imaging of micro…
  openalex Marco Raffaele Cosenza, Alice Gaiatto, Büşra Erarslan Uysal, Álvaro Andrades 等 2025-10-29 置信度 0.72 Dicentric chromosomeBiologyGenome instabilityChromosomeSomatic cell
• The effects of amino acid substitution of spike protein and genomic recombination on the evolution of SARS-CoV-2
  Over three years' pandemic of 2019 novel coronavirus disease (COVID-19), multiple variants and novel subvariants have emerged successively, outcompeted earlier variants and become predominant. The sequential emergence of variants reflects the evolutionary proc…
  openalex Letian Fang, Jie Xu, Yue Zhao, Junyan Fan 等 2023-07-25 置信度 0.72 BiologyAntigenicityGeneticsVirologyMutation
• A non-canonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML
  RNA-binding proteins (RBPs) form a large and diverse class of factors, many members of which are overexpressed in hematologic malignancies. RBPs participate in various processes of messenger RNA (mRNA) metabolism and prevent harmful DNA:RNA hybrids or R-loops.…
  openalex Shiva Bamezai, Alex Jose Pulikkottil, Tribhuwan Yadav, Vegi M. Naidu 等 2023-05-05 置信度 0.72 BiologyMyeloid leukemiaHaematopoiesisStem cellProgenitor cell
• Characterization of genomic structures and expression profiles of three tandem repeats of a mouse double homeobox gene: Duxbl
  We identified and cloned a mouse double homeobox gene (Duxbl), which encodes two homeodomains. Duxbl gene, a tandem triplicate produces two major transcripts, Duxbl and Duxbl-s. The amino acid sequences of Duxbl homeodomains are most similar to those of human …
  openalex Shey‐Lin Wu, Ming‐Shiun Tsai, Swee‐Hee Wong, Hsiu‐Mei Hsieh‐Li 等 2010-01-08 置信度 0.72 BiologyMyogenesisHomeoboxMyogeninC2C12
• Human metapneumovirus (hMPV) in 2025: emerging trends and insights from community and hospital-based respiratory panel analyses—a comprehensive review
  Human metapneumovirus (hMPV) is a significant respiratory pathogen, primarily impacting young, elderly, and immunocompromised populations. While the clinical presentations are similar to those of other respiratory viruses such as respiratory syncytial virus (R…
  openalex Keyhan Mohammadi, Samireh Faramarzi, Shakila Yaribash, Zahra Valizadeh 等 2025-05-20 置信度 0.72 Human metapneumovirusMetapneumovirusVirologyBiologyRespiratory system
• Non-geneticist champions are essential to the mainstreaming of genomic medicine
  Demand for genomic testing is increasing across medicine as it paves the way for earlier diagnoses and targeted management of patients with rare diseases. The diagnostic utility of genomic testing has been clearly established, with evidence demonstrating value…
  openalex Michael P. Mackley, Emma Weisz, Robin Z. Hayeems, Clara Gaff 等 2025-01-03 置信度 0.72 GeneticistGenomic medicineHuman geneticsMainstreamingGenetics
• Genomic analysis of 116 autism families strengthens known risk genes and highlights promising candidates
  Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a strong genetic component in which rare variants contribute significantly to risk. We performed whole genome and/or exome sequencing (WGS and WES) and SNP-array analysis to identify…
  openalex Marta Viggiano, Fabiola Ceroni, Paola Visconti, Annio Posar 等 2024-03-22 置信度 0.72 GeneticsCopy-number variationPenetranceBiologyCandidate gene
• TIN2, a new regulator of telomere length in human cells
  openalex Sahn-Ho Kim, Patrick Kaminker, Judith Campisi 1999-12-01 置信度 0.72 TelomereBiologyShelterinTelomeraseTelomere-binding protein
• Functional impact of global rare copy number variation in autism spectrum disorders
  openalex Dalila Pinto, Alistair T. Pagnamenta, Lambertus Klei, Richard Anney 等 2010-06-08 置信度 0.72 Copy-number variationAutismGeneticsBiologyGenome
• Genomics in Epidemiology and Disease Surveillance: An Exploratory Analysis
  Genomics has revolutionized epidemiology and disease surveillance by providing powerful tools for identifying, tracking, and analyzing pathogens at the molecular level. This exploratory analysis examines the integration of genomic with traditional epidemiologi…
  openalex Shraddha Tiwari, Thakur Dhakal, Baek-Jun Kim, Gab‐Sue Jang 等 2025-12-01 置信度 0.72 GenomicsOutbreakDiseaseInfectious disease (medical specialty)Epidemiology
• Genomic evolution of influenza during the 2023–2024 season, the johns hopkins health system
  Influenza, a human disease caused by viruses in the Orthomyxoviridae family, is estimated to infect 5% -10 % of adults and 20% -30 % of children annually. Influenza A (IAV) and Influenza B (IBV) viruses accumulate amino acid substitutions (AAS) in the hemagglu…
  openalex Madeline Yunker, David A. Villafuerte, Amary Fall, Julie M. Norton 等 2024-07-26 置信度 0.72 GerontologyBiologyMedicine
• Metabolic Engineering of Terpenoid Biosynthesis in Medicinal Plants: From Genomic Insights to Biotechnological Applications
  Terpenoids, which are essential pharmaceutical compounds, encounter significant production challenges due to their low yields in native plants and associated ecological concerns. This review summarizes recent advances in metabolic engineering strategies applie…
  openalex Changfeng Guo, Si Xu, Xiaoyun Guo 2025-09-05 置信度 0.72 Metabolic engineeringTerpenoidBiosynthesisBiotechnologyBiology
• Analysis of Association between Vitamin D Deficiency and Insulin Resistance
  Recent evidence revealed extra skeleton activity of vitamin D, including prevention from cardiometabolic diseases and cancer development as well as anti-inflammatory properties. It is worth noting that vitamin D deficiency is very common and may be associated …
  openalex Izabela Szymczak-Pajor, Agnieszka Śliwińska 2019-04-06 置信度 0.72 Insulin resistanceMedicinevitamin D deficiencyInsulinEndocrinology
• Codon usage patterns and genomic variation analysis of chloroplast genomes provides new insights into the evolution of Aroideae
  Aroideae is an important subfamily of the Araceae family and contains many plants with medicinal and edible value. It is difficult to identify and classify Aroideae species accurately on the basis of morphology alone because of their polymorphic phenotypic tra…
  openalex Xinbi Jia, Jiaqi Wei, Yuewen Chen, Chenghong Zeng 等 2025-02-05 置信度 0.72 Variation (astronomy)GenomeEvolutionary biologyBiologyChloroplast
• The genomic and epigenomic landscapes of hemizygous genes across crops with contrasting reproductive systems
  Hemizygous genes, which are present on only one of the two homologous chromosomes of diploid organisms, have been mainly studied in the context of sex chromosomes and sex-linked genes. However, these genes can also occur on the autosomes of diploid plants due …
  openalex Yanling Peng, Yiwen Wang, Yuting Liu, Xinyue Fang 等 2025-02-07 置信度 0.72 BiologyGeneticsGeneGenomeAutosome
• Genomic and phenomic prediction for soybean seed yield, protein, and oil
  Developments in genomics and phenomics have provided valuable tools for use in cultivar development. Genomic prediction (GP) has been used in commercial soybean [Glycine max L. (Merr.)] breeding programs to predict grain yield and seed composition traits. Phen…
  openalex Liza Van der Laan, Kyle Parmley, Mojdeh Saadati, Hernan Torres Pacin 等 2025-02-19 置信度 0.72 PhenomicsBiologyBest linear unbiased predictionGrowing seasonGenome-wide association study
• The socio-economic factors affecting the emergence and impacts of new genomic techniques in agriculture: A scoping review
  The development of new genomic techniques (NGTs) has the potential to address some future challenges related to food security, agroecology and global warming. NGTs encompass ZFN-1, ZFN-2 and ZFN-3 technologies, TALENs, Meganucleases, CRISPR-Cas, and Oligonucle…
  openalex Stephane Lemarié, Stéphan Marette 2022-07-30 置信度 0.72 Food securityAgricultureIntellectual propertyBusinessPolitical science
• Mapping MAVE data for use in human genomics applications
  BACKGROUND: Experimental data from functional assays have a critical role in interpreting the impact of genetic variants. Assay data must be unambiguously mapped to a reference genome to make it accessible, but it is often reported relative to assay-specific s…
  openalex Jeremy A. Arbesfeld, Estelle Y. Da, James Stevenson, Kori Kuzma 等 2025-06-25 置信度 0.72 EnsemblGenomicsDECIPHERPersonal genomicsComputational biology
• Driving Global Health equity and precision medicine through African genomic data
  Significant gaps persist despite the progress in raising awareness of genomic diversity and including individuals of African ancestry in genomic research. African populations remain underrepresented in genomic studies despite their deep evolutionary history, d…
  openalex Oyesola Ojewunmi, Segun Fatumo 2025-04-30 置信度 0.72 BiologyPrecision medicineBiobankHealth equityGenomic medicine
• Deep learning-driven survival prediction in pan-cancer studies by integrating multimodal histology-genomic data
  Accurate cancer prognosis is essential for personalized clinical management, guiding treatment strategies and predicting patient survival. Conventional methods, which depend on the subjective evaluation of histopathological features, exhibit significant inter-…
  openalex Yongfei Hu, Xinyu Li, Ying Yi, Yan Huang 等 2025-03-01 置信度 0.72 Artificial intelligenceDeep learningCancerComputer scienceMultimodal therapy
• Draft genome of a commonly misdiagnosed multidrug resistant pathogen Candida auris
  BACKGROUND: Candida auris is a multidrug resistant, emerging agent of fungemia in humans. Its actual global distribution remains obscure as the current commercial methods of clinical diagnosis misidentify it as C. haemulonii. Here we report the first draft gen…
  openalex Sharanya Chatterjee, Shuba Varshini Alampalli, Rishi Kumar Nageshan, Sivarajan T. Chettiar 等 2015-09-07 置信度 0.72 Candida aurisBiologyFungal pathogenGenomeOpportunistic pathogen
• Genomic evidence supports the “long chronology” for the peopling of Sahul
  The timing of the settlement of Sahul—the Pleistocene landmass formed by present-day New Guinea, Australia, and Tasmania that existed until ~9000 years ago (~9 ka)—remains highly contentious. The so-called “long chronology” posits the first main arrivals at ~6…
  openalex Francesca Gandini, Mafalda Almeida, M. George B. Foody, Nano Nagle 等 2025-11-28 置信度 0.72 Context (archaeology)PleistoceneLineage (genetic)Range (aeronautics)Evolutionary biology
• slendr: a framework for spatio-temporal population genomic simulations on geographic landscapes
  One of the goals of population genetics is to understand how evolutionary forces shape patterns of genetic variation over time. However, because populations evolve across both time and space, most evolutionary processes also have an important spatial component…
  openalex Martin Petr, Benjamin C. Haller, Peter L. Ralph, Fernando Racimo 2023-12-15 置信度 0.72 GeographyEvolutionary biologyPopulationCartographyComputer science
• Critical assessment of coalescent simulators in modeling recombination hotspots in genomic sequences
  BACKGROUND: Coalescent simulation is pivotal for understanding population evolutionary models and demographic histories, as well as for developing novel analytical methods for genetic association studies for DNA sequence data. A plethora of coalescent simulato…
  openalex Tao Yang, Hong‐Wen Deng, Tianhua Niu 2014-01-03 置信度 0.72 Coalescent theoryComputational biologyRecombinationDNA microarrayBiology
• A Genomic Surveillance Circuit for Emerging Viral Pathogens
  Genomic surveillance has been crucial in monitoring the evolution and spread of SARS-CoV-2. In Andalusia (Spain), a coordinated genomic surveillance circuit was established to systematically sequence and analyze viral genomes across the region. This initiative…
  openalex Carlos S. Casimiro‐Soriguer, Marí­a Pí­a Lara, Andrea Aguado, Carlos Loucera 等 2025-04-16 置信度 0.72 GenomePreparednessComputational biologyPublic health surveillanceIdentification (biology)
• Integrative Genomics and Precision Breeding for Stress-Resilient Cotton: Recent Advances and Prospects
  Developing climate-resilient and high-quality cotton cultivars remains an urgent challenge, as the key target traits yield, fibre properties, and stress tolerance are highly polygenic and strongly influenced by genotype–environment interactions. Recent advance…
  openalex Zahra Ghorbanzadeh, Bahman Panahi, Leila Purhang, Zhila Hossein Panahi 等 2025-10-15 置信度 0.72 IdeotypeGenomicsBiologyGenomic selectionBiotechnology
• RepeatsDB in 2025: expanding annotations of structured tandem repeats proteins on AlphaFoldDB
  RepeatsDB (URL: https://repeatsdb.org) stands as a key resource for the classification and annotation of Structured Tandem Repeat Proteins (STRPs), incorporating data from both the Protein Data Bank (PDB) and AlphaFoldDB. This latest release features substanti…
  openalex Damiano Clementel, Paula Nazarena Arrías, Soroush Mozaffari, Zarifa Osmanli 等 2024-10-11 置信度 0.72 AnnotationBiologyKey (lock)Tandem repeatInterface (matter)
• Genomic driven factors enhance biocatalyst-related cellulolysis potential in anaerobic digestion
  openalex Huichuan Zhuang, Po‐Heng Lee, Zhuoying Wu, Houde Jing 等 2021-04-19 置信度 0.72 CellulosomeCellulosic ethanolBiomass (ecology)BioenergyCellulose
• Integrative multi-environmental genomic prediction in apple
  Genomic prediction for multiple environments can aid the selection of genotypes suited to specific soil and climate conditions. Methodological advances allow effective integration of phenotypic, genomic (additive, nonadditive), and large-scale environmental (e…
  openalex Michaela Jung, Carles Quesada‐Traver, Morgane Roth, María José Aranzana 等 2024-11-20 置信度 0.72 BiologyBiotechnologyComputational biology
• Linezolid in the Focus of Antimicrobial Resistance of Enterococcus Species: A Global Overview of Genomic Studies
  Linezolid (LNZ) is a synthetic oxazolidinone antibiotic that inhibits bacterial protein synthesis through binding to ribosomal RNA, also preventing the assembly of the initiation complex during translation. It is one of the last-line therapeutic options for se…
  openalex Slavil Peykov, Boris Kirov, Tanya Strateva 2025-08-24 置信度 0.72 LinezolidAntimicrobialEnterococcusAntibiotic resistanceBiology
• Two patients walk into a clinic...a genomics perspective on the future of schizophrenia
  Progress is being made in schizophrenia genomics, suggesting that this complex brain disorder involves rare, moderate to high-risk mutations and the cumulative impact of small genetic effects, coupled with environmental factors. The genetic heterogeneity under…
  openalex Aiden Corvin 2011-11-08 置信度 0.72 Schizophrenia (object-oriented programming)GenomicsBiologyPerspective (graphical)Disease
• Driver pattern identification over the gene co-expression of drug response in ovarian cancer by integrating high throughput genomics data
  Multiple types of high throughput genomics data create a potential opportunity to identify driver patterns in ovarian cancer, which will acquire some novel and clinical biomarkers for appropriate diagnosis and treatment to cancer patients. To identify candidat…
  openalex Xinguo Lu, Jibo Lu, Bo Liao, Xing Li 等 2017-11-17 置信度 0.72 Computational biologyMutationCandidate geneGenomicsBiology
• The Consortium for Genomic Diversity, Ancestry, and Health in Colombia (CÓDIGO): building local capacity in genomics and bioinformatics
  The Consortium for Genomic Diversity, Ancestry, and Health in Colombia (CÓDIGO) aims to build a community of Colombian researchers in support of local capacity in genomics, bioinformatics, and precision health. Here, we present the first CÓDIGO data release an…
  openalex Leonardo Mariño‐Ramírez, Shivam Sharma, James Matthew Hamilton, T. Nguyen 等 2025-07-17 置信度 0.72 Genetic genealogyGeneticsGenomicsBiologyGenome
• Genomic conflicts and sexual antagonism in human health: insights from oxytocin and testosterone
  We review the hypothesized and observed effects of two of the major forms of genomic conflicts, genomic imprinting and sexual antagonism, on human health. We focus on phenotypes mediated by peptide and steroid hormones (especially oxytocin and testosterone) be…
  openalex Mikael Mökkönen, Bernard J. Crespi 2015-01-09 置信度 0.72 BiologyAntagonismTestosterone (patch)OxytocinGenetics
• Unraveling the genomic diversity and admixture history of captive tigers in the United States
  Genomic studies of endangered species have primarily focused on describing diversity patterns and resolving phylogenetic relationships, with the overarching goal of informing conservation efforts. However, few studies have investigated genomic diversity housed…
  openalex Ellie E. Armstrong, Jazlyn A. Mooney, Katherine A. Solari, Bernard Kim 等 2024-09-19 置信度 0.72 SubspeciesTigerBiologyInbreedingGenetic diversity
• Sucralose: A Review of Environmental, Oxidative and Genomic Stress
  This review explores current knowledge on the environmental, oxidative, and genomic effects of sucralose (E955), an artificial sweetener widely used in food products, including those for children, and known to cross both the placental barrier and into breast m…
  openalex Volodymyr Tkach, Тетяна Морозова, Isabel Gaivão, Natasha Gomes de Miranda 等 2025-07-01 置信度 0.72 SucraloseAquatic ecosystemOxidative stressBiologyBiotechnology
• CRISPR-Cas systems as next-generation antimicrobials: a systemic review of mechanisms, delivery strategies, and translational challenges.
  europepmc 2026 置信度 0.80
• Bridging science and hope: the evolving story of gene therapy for neuromuscular diseases.
  europepmc 2026 置信度 0.80
• Modern genomic and omics-based technologies for millet breeding and genetic improvement.
  europepmc 2026 置信度 0.80
• The Journey of Gene Therapy in Sickle Cell Disease: How Molecular Advances Meet Clinical Care.
  europepmc 2026 置信度 0.80
• Improving iSpyMacCas9 multiplex genome editing in rice by CRISPR-combo-mediated BBM1 activation.
  europepmc 2026 置信度 0.80
• The epigenetic landscape of heterosis: integrating multi-layer regulatory insights and navigating the path to causality.
  europepmc 2026 置信度 0.80
• [Research progress of the CRISPR-Cas system in the detection and elimination of antibiotic resistance genes].
  europepmc 2026 置信度 0.80
• Application of Gene Editing Technology in Poultry.
  europepmc 2026 置信度 0.80
• Heat-induced mutator: DNA repair polymerase Polλ shapes mutation under heat.
  europepmc 2026 置信度 0.80
• Gene Editing Strategies for Duchenne Muscular Dystrophy: From Molecular Mechanisms to Clinical Translation.
  europepmc 2026 置信度 0.80
• Commentary: CRISPR-Cas9 mediated editing of starch branching enzyme, SBE2 gene in potato for enhanced resistant starch for health benefits.
  europepmc 2026 置信度 0.80
• DMT1 regulates systemic trace metal handling and developmental outcomes: Insights from targeted mutagenesis in zebrafish.
  europepmc 2026 置信度 0.80
• Harnessing CRISPR-Cas Technology for Precision Antimicrobial Targeting.
  europepmc 2026 置信度 0.80
• Transgenesis and targeted mutagenesis in the human-parasitic nematode <i>Strongyloides stercoralis</i>.
  europepmc 2026 置信度 0.80
• Negative Regulators of Rice Agronomic Traits: Functional Insights and Applications in Genome Editing-Based Breeding.
  Rice is the staple crop for more than half of the global population, and improving grain yield, grain quality, and stress resistance remain central goals of modern rice breeding. Among current precision breeding strategies, genome editing has created new oppor…
  europepmc 2026 置信度 0.80
• Recent Advances in the Non-viral Delivery of Genes to Central Nervous System Disorders.
  europepmc 2026 置信度 0.80
• AlphaFold3-guided tracrRNA redesign yields small monomeric Cas12f RNPs.
  europepmc 2026 置信度 0.80
• Plant responses to cold stress: molecular and physiological adaptive mechanisms with breeding advances.
  europepmc 2026 置信度 0.80
• Research progress and applications of gene activation editing technology in crops.
  europepmc 2026 置信度 0.80
• Multiplex gene editing drives revolution in crop breeding: overlaid editing of multiple genes and customization of complex traits.
  europepmc 2026 置信度 0.80
• Compact Cas12f enables genome editing in avian cells.
  europepmc 2026 置信度 0.80
• CRISPR/Cas Genome Editing and Its Applications in Cereal Crop Improvement.
  europepmc 2026 置信度 0.80
• CRISPR-Cas9 Therapeutics in Early Clinical Development: Delivery and Molecular Diagnostics.
  europepmc 2026 置信度 0.80
• Genome editing between wonder and rejection.
  europepmc 2026 置信度 0.80
• A CRISPR workshop series for diverse learners in Hawai'i: design, implementation, and outcomes across 3 years.
  europepmc 2026 置信度 0.80